Title: The metabolic effect of fluoride inhibition of anaerobic glycolysis during hemorrhagic shock
Abstract: Sodium fluoride, a metabolic inhibitor which blocks an essential step in anaerobic glycolysis, was administered to cats prior to hemorrhage. Lower serum lactate (P = .01) in the animals receiving NaF indicates that anaerobic glycolysis was effectively suppressed. No significant differences in survival, pH, PO2, PCO2, or arterial and venous pressures were noted in a similar group of animals which did not receive NaF. These data suggest that anaerobic glycolysis accompanying hemorrhage merely reflects the presence of cellular hypoxia and is in itself of little or no metabolic significance.
Publication Year: 1969
Publication Date: 1969-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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