Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia

Name: Work Video:
Duration: 3 min 30 s
Description: Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic-phase chronic myeloid leukemia (CML) who have had no response to interferon alfa. We compared the efficacy of imatinib with that of interferon alfa combined with low-dose cytarabine in newly diagnosed chronic-phase CML.
Stephen G. O’Brien; François Guilhot; Richard A. Larson; Insa Gathmann; Michele Baccarani; Francisco Cervantes; Jan J. Cornelissen; Thomas Fischer; Andreas Hochhaus; Timothy P. Hughes; Klaus Lechner; Johan Lanng Nielsen; Philippe Rousselot; Josy Reiffers; Giuseppe Saglio; John D. Shepherd; Bengt Simonsson; Aloïs Gratwohl; John M. Goldman; Hagop M. Kantarjian; Kerry Taylor; Gregor Verhoef; Ann E. Bolton; Renaud Capdeville; Brian J. Druker
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