The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells

Name: Work Video:
Duration: 3 min 30 s
Marcello Maggiolini; Adele Vivacqua; Giovanna Fasanella; Anna Grazia Recchia; Diego Sisci; Vincenzo Pezzi; Daniela Montanaro; Anna Maria Musti; Didier Picard; Sebastiano Andò
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659, 665, 677, 684, 690, 1236, 1258, 1273, 1882, 1900, 1908, 1952, 2000, 2004, 2039, 2118, 2124, 2452, 2463, 2511, 2612, 2814, 2822, 2834, 2859, 2881, 2886, 2894, 2917, 2984, 3070, 3133, 3164, 3331, 3334, 3352, 3559, 3576, 3582, 3602, 3608, 3616, 3625, 3641, 3661, 3669, 4208, 4295, 4331], 'evidence': [4, 190], 'concerning': [5, 191], 'estrogen': [6, 23, 54, 192, 209, 240, 381, 422, 470], 'effects': [7, 193, 658, 3640], 'cannot': [8, 194], 'be': [9, 195], 'explained': [10, 196], 'by': [11, 135, 197, 321, 885, 1035, 1053, 1353, 1653, 1956, 1994, 2029, 2447, 2477, 2493, 2700, 2870, 2954, 2978, 2989, 3153, 3355, 3481, 3496, 3546, 3627, 4190], 'the': [12, 20, 30, 33, 72, 92, 164, 174, 198, 206, 216, 219, 258, 278, 350, 360, 480, 656, 662, 666, 675, 695, 700, 1008, 1045, 1051, 1234, 1256, 1271, 1662, 1883, 1897, 1904, 1961, 1964, 1988, 1995, 2022, 2119, 2122, 2127, 2171, 2383, 2437, 2441, 2445, 2455, 2466, 2482, 2501, 2596, 2602, 2643, 2812, 2838, 2857, 2871, 2899, 2933, 2940, 2949, 2955, 2975, 3027, 3158, 3188, 3213, 3303, 3335, 3341, 3430, 3488, 3497, 3542, 3547, 3560, 3574, 3579, 3586, 3600, 3614, 3638, 3658, 3670, 3674, 4206, 4209, 4241, 4247, 4251, 4322], 'classic': [13, 199], 'model': [14, 200, 664], 'hormone': [16, 202], 'action,': [17, 203], 'which': [18, 204, 476, 2125, 2583, 2861, 2974, 3566], 'involves': [19, 205], 'binding': [21, 207, 1729, 2123, 2462], 'to': [22, 162, 208, 348, 467, 654, 661, 679, 694, 876, 1238, 1660, 1730, 1893, 1969, 2037, 2176, 2181, 2340, 2434, 2465, 2506, 2795, 2939, 2948, 3067, 3098, 3157, 3176, 3358, 3418, 3447, 3487, 3689, 4291, 4315], 'receptors': [24, 210, 471, 703], '(ERs)': [25, 211], 'α': [26, 212, 473], 'and': [27, 29, 59, 71, 77, 114, 120, 137, 150, 160, 213, 215, 245, 257, 263, 300, 306, 323, 336, 346, 457, 464, 468, 474, 686, 790, 1278, 1359, 1749, 1879, 1890, 1947, 1998, 2032, 2133, 2139, 2169, 2431, 2459, 2461, 2485, 2545, 2564, 2580, 2595, 2607, 2640, 2690, 2705, 2754, 2818, 2854, 2891, 2913, 2920, 3018, 3033, 3040, 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2349, 2487, 3485, 3494, 3649, 4187], 'repressed': [102, 288], 'GPR30-expressing': [104, 290], 'cells': [106, 124, 292, 310, 2168, 2518, 2732, 2746, 2756, 2776, 2825, 2922, 2968, 3416, 4271, 4297], 'transfected': [107, 125, 293, 311, 3339, 3413, 3438], 'antisense': [110, 296, 3327], 'oligonucleotide': [111, 297], 'against': [112, 298, 3190], 'GPR30': [113, 128, 299, 314, 1012, 2689], 'reconstituted': [115, 301], 'GPR30-deficient': [117, 303], 'MDA-MB': [118, 304], '231': [119, 305], 'BT-20': [121, 307, 2728], 'a': [127, 141, 313, 327, 888, 1267, 1342, 1743, 2116, 2177, 2378, 2401, 2722, 2734, 2876, 3024, 3131, 3171, 3177, 3329, 3593, 3646, 3653, 3667, 4237, 4285, 4327, 4346], 'vector.': [130, 316], 'GPR30-dependent': [131, 317], 'activation': [132, 318, 2038, 2446, 3558, 3601, 4207], 'ERK1/2': [134, 320], 'E2': [136, 159, 322, 345, 678, 1003, 1036, 1237, 2432, 2448, 2478, 3454, 3478, 3628, 4191, 4200, 4262], 'phytoestrogens': [138, 161, 324, 347, 2483, 3449, 3630, 4198, 4264], 'occurs': 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[512], 'Rev.': [513, 527, 1297, 1563, 1684, 2276, 3899], '1993;': [514, 1565, 2278, 3901, 4017], '14:': [515, 924, 1616, 2104, 3952, 4036], '459-479Crossref': [516], 'PubMed': [517, 532, 582, 614, 641, 718, 766, 783, 813, 834, 869, 910, 926, 947, 989, 1073, 1110, 1126, 1149, 1169, 1202, 1226, 1334, 1370, 1387, 1418, 1442, 1459, 1486, 1510, 1526, 1553, 1583, 1604, 1618, 1721, 1774, 1790, 1810, 1826, 1858, 1874, 1942, 1983, 2017, 2061, 2075, 2094, 2106, 2150, 2215, 2239, 2266, 2320, 2364, 2397, 2423, 2635, 2684, 3008, 3282, 3321, 3465, 3534, 3718, 3735, 3766, 3790, 3807, 3822, 3846, 3862, 3889, 3919, 3940, 3954, 3995, 4020, 4038, 4054, 4082, 4106, 4134, 4180, 4230], '(0)': [519], '3Tsai': [522], 'M.-J.': [523], "O'Malley": [524], 'B.W.': [525], 'Annu.': [526], 'Biochem.': [528, 576, 1547, 2260, 2628, 3883], '1994;': [529, 1577, 1601, 1852, 2014, 2058, 2072, 2147, 3913, 3937], '63:': [530, 1769], '451-486Crossref': [531], '(2666)': [534], '4Maggiolini': [537], 'Bonofiglio': [539, 604, 631, 2668, 3387, 3518], 'D.': [540, 548, 605, 632, 855, 1096, 1134, 1185, 2669, 2677, 3002, 3388, 3396, 3519, 3527, 4064, 4089], 'Marsico': [541, 3389], 'S.': [542, 550, 565, 573, 594, 624, 942, 953, 1144, 1593, 1636, 2296, 2359, 2392, 2411, 3309, 3390, 3398, 3929, 3972, 4015, 4091, 4101, 4146], 'Panno': [543, 3391], 'M.L.': [544, 601, 3392], 'Cenni': [545, 3393], 'B.': [546, 1426, 1494, 1534, 2199, 2223, 2247, 3394, 3774, 3830, 3870, 4154], 'Picard': [547, 3001, 3395], 'Andò': [549, 572, 3397], 'Mol.': [551, 577, 713, 732, 921, 1022, 1068, 1164, 1381, 1436, 1453, 1505, 1521, 1548, 1821, 1869, 1936, 2209, 2234, 2261, 3399, 3729, 3784, 3801, 3841, 3857, 3884, 4174, 4225], 'Pharmacol.': [552, 3400], '2001;': [553, 758, 981, 2415, 3279, 3401], '60:': [554, 3262, 3402], '595-602PubMed': [555, 3403], '5Maggiolini': [558], 'Statti': [560], 'G.': [561, 592, 628, 798, 822, 840, 1081, 1393, 1782, 2184, 2312, 3741, 3987], 'Vivacqua': [562, 621, 2670, 3520], 'A.': [563, 588, 596, 603, 609, 622, 626, 708, 793, 801, 838, 846, 848, 895, 918, 943, 1063, 1079, 1087, 1089, 1145, 1159, 1210, 1410, 1559, 1573, 1642, 1802, 2272, 2302, 2661, 2671, 3231, 3456, 3511, 3521, 3758, 3895, 3909, 3978, 4016, 4093, 4102], 'Gabriele': [564, 593, 623], 'Rago': [566, 597, 629], 'V.': [567, 598, 630, 1638, 1780, 2298, 2310, 3974, 3985, 4220], 'Loizzo': [568], 'Menichini': [570], 'F.': [571, 807, 863, 1104, 1561, 1640, 1931, 2274, 2300, 3273, 3897, 3976, 4028], 'J.': [574, 755, 777, 809, 829, 865, 1106, 1121, 1161, 1187, 1215, 1518, 1545, 1614, 1786, 1806, 1849, 2102, 2258, 2316, 2412, 2623, 3256, 3310, 3854, 3881, 3950, 3991, 4009, 4034, 4050, 4060, 4070, 4071, 4114, 4122, 4123, 4144, 4150], 'Steroid': [575, 1546, 2259, 3882], 'Biol.': [578, 756, 1216, 1383, 1455, 1469, 1549, 1850, 1938, 2046, 2057, 2085, 2146, 2262, 2413, 3003, 3731, 3803, 3885, 4072, 4124, 4176], '2002;': [579, 1166, 1199, 2632, 2681, 3531], '82:': [580], '315-322Crossref': [581], '(140)': [584], '6Vivacqua': [587], 'Recchia': [589], 'A.G.': [590, 620], 'Fasanella': [591, 627], 'Carpino': [595, 625], 'Di': [599, 794, 841, 1082], 'Gioia': [600], 'Leggio': [602], 'Maggiolini': [606, 633, 2666, 3516], 'Liguori': [608], 'Endocrine.': [610], '2003;': [611, 780, 1218, 3313], '22:': [612], '275-284Crossref': [613], '(84)': [616], '7Recchia': [619], 'Food': [635], 'Addit.': [636], 'Contam.': [637], '2004;': [638], '21:': [639, 2682, 3532], '134-144Crossref': [640], '(31)': [643], 'Scholar).': [645, 991, 1030, 1230, 1338, 1648, 1725, 1876, 2110, 2154, 2324, 2366, 2399, 2688, 3012, 3325, 3469], 'Although': [646], 'it': [647, 994, 2368], 'often,': [649], 'but': [650, 2348], 'not': [651, 1038, 2350, 3504, 3683], 'always,': [652], 'straightforward': [653], 'link': [655], 'physiological': [657], 'estrogens': [660], 'genomic': [663], 'ligand-receptor': [667], 'activity,': [669], 'considerable': [670], 'controversy': [671], 'still': [672], 'exists': [673], 'on': [674, 1050, 1747, 2436, 2856, 3170, 3578, 4246, 4356], 'elicit': [680], 'transcriptional': [681, 3659], 'responses': [682, 1033], 'independently': [683, 2510], 'ERβ.': [687], 'variety': [689], 'molecules': [691], 'located': [692, 1734], 'close': [693], 'plasma': [696], 'membrane,': [697], '(GPRs)': [704], '(8Razandi': [705, 1060], 'Pedram': [707, 894, 917, 1062, 1158, 1209], 'Greene': [709, 1064], 'G.L.': [710, 1065], 'Levin': [711, 904, 919, 1066, 1162, 1213], 'E.R.': [712, 905, 920, 1067, 1163, 1214], 'Endocrinol.': [714, 733, 922, 1023, 1069, 1165, 1438, 1506, 1522, 1822, 1870, 2211, 2235, 3786, 3842, 3858, 4226], '1999;': [715, 831, 1070, 1123, 3005, 4177], '13:': [716, 1071], '307-319Crossref': [717, 1072], '(998)': [720, 1075], '9Filardo': [723], 'E.J.': [724, 1014], 'Quinn': [725, 1015], 'J.A.': [726, 969, 1016, 1195], 'Bland': [727, 1017], 'K.I.': [728, 1018], 'Frackelton': [729, 1019], 'Jr.,': [730, 821, 1020, 1325, 1712, 3239], 'A.R.': [731, 1021], '2000;': [734, 866, 923, 944, 1024, 1107, 1146, 3261], '10:': [735, 1025, 1457, 1788, 1808, 2318, 3805, 3993], '1649-1660Crossref': [736, 1026], '(1111)': [738, 1028], '10Wyckoff': [741], 'M.H.': [742], 'Chambliss': [743], 'K.L.': [744], 'Mineo': [745], 'C.': [746, 859, 1100, 1634, 2294, 2663, 2675, 3513, 3525, 3970, 4062, 4112, 4120], 'Yuhanna': [747], 'I.S.': [748], 'Mendelsohn': [749, 1196], 'M.E.': [750, 1197, 1395, 1467, 1480, 1575, 1935, 1978, 2186, 3743, 3816, 3911], 'Mumby': [751], 'S.M.': [752], 'Shaul': [753, 1188], 'P.W.': [754, 1189], 'Chem.': [757, 1217, 1851, 2414, 3004, 4073, 4125], '276:': [759, 2416], '27071-27076Abstract': [760], '(261)': [768], '11Kroeze': [771], 'W.K.': [772], 'Sheffler': [773], 'D.J.': [774, 4001], 'Roth': [775], 'B.L.': [776], 'Cell': [778, 2056, 2145, 2725, 4157], 'Sci.': [779, 940, 1142, 4013, 4099], '116:': [781], '4867-4869Crossref': [782], '(249)': [785], 'Scholar),': [787, 871, 1987, 2021, 2427, 3405, 3538, 4234], 'Src,': [788], 'Ras,': [789], 'Raf': [791], '(12Migliaccio': [792], 'Domenico': [795, 842, 1083], 'Castoria': [797, 839, 1080], 'de': [799, 844, 1085], 'Falco': [800, 845, 1086], 'Bontempo': [802, 860, 1101], 'P.': [803, 861, 1102, 1157, 1179, 1191, 1764, 1766, 1800, 1862, 4095, 4148], 'Nola': [804], 'E.': [805, 903, 1136, 1838, 1923, 2737], 'Auricchio': [806, 862, 1103], 'EMBO': [808, 864, 1105, 1613, 1785, 1805, 2101, 2315, 3949, 3990, 4033, 4049], '1996;': [810, 1644, 2304, 3980, 4051], '15:': [811, 4052], '1292-1300Crossref': [812], '(857)': [815], '13Singh': [818], 'Setalo': [820], 'Guan': [823, 4117], 'X.': [824, 1818], 'Warren': [825], 'Toran-Allerand': [827], 'C.D.': [828], 'Neurosci.': [830, 1122], '19:': [832, 867, 1108, 1124, 4178], '1179-1188Crossref': [833], '14Migliaccio': [837, 1078], 'Bilancio': [847, 1088], 'Lombardi': [849, 1090], 'Vitorria': [851, 1092], 'Barone': [852, 1093], 'Ametrano': [854, 1095], 'Zannini': [856, 1097], 'M.S.': [857, 1098], 'Abbondanza': [858, 1099], '5406-5417Crossref': [868, 1109], 'recently': [873], 'been': [874, 996, 3706], 'recognized': [875, 1993], 'mediate': [877], 'multiple': [878, 1957], 'stimuli,': [880], 'those': [883, 4294], 'induced': [884, 1352, 2476, 2977], 'cell': [889, 1058, 1244, 1275, 1912], 'context-specific': [890], '(15Morey': [892], 'A.K.': [893], 'Razandi': [896], 'Prins': [898], 'B.A.': [899], 'Hu': [900, 4151], 'R.-M.': [901], 'Biesiada': [902], 'Endocrinology.': [906, 1600, 2360, 2393, 3936], '1997;': [907, 4074], '138:': [908], '3330-3339Crossref': [909], '(144)': [912], '16Razandi': [915], '1434-1447Crossref': [925], '17Shevde': [929], 'N.K.': [930], 'Bendixen': [931], 'A.C.': [932], 'Dienger': [933], 'K.M.': [934], 'Pike': [935], 'J.W.': [936, 4167], 'Proc.': [937, 1139, 4010, 4096], 'Natl.': [938, 1140, 4011, 4097], 'Acad.': [939, 1141, 4012, 4098], 'U.': [941, 1143, 4014, 4100], '97:': [945, 1147], '7829-7834Crossref': [946], '(401)': [949], '18Kousteni': [952], 'Bellido': [954], 'T.': [955, 1295, 1305, 1311, 1323, 1682, 1692, 1698, 1710, 1842, 1848, 2083], 'Plotkin': [956], 'L.I.': [957], "O'Brien": [958], 'C.A.': [959, 1114], 'Bodenner': [960], 'D.L.': [961], 'Han': [962, 964], 'L.': [963, 1183, 1499, 1539, 1628, 1630, 1796, 2228, 2252, 2288, 2290, 3835, 3875, 3964, 3966, 4005], 'K.': [965, 1589, 2618, 2627, 3925, 4068, 4118], 'DiGregorio': [966], 'G.B.': [967], 'Katzenellenbogen': [968, 970], 'B.S.': [971], 'Roberson': [972], 'P.K.': [973], 'Weinstein': [974, 4172], 'R.S.': [975], 'Jilka': [976], 'R.L.': [977], 'Manolagas': [978], 'S.C.': [979, 3271], '104:': [982], '719-730Abstract': [983], 'For': [992, 3013, 3326], 'instance,': [993], 'proposed': [997], 'induces': [1004], 'ERK': [1005], 'phosphorylation': [1006, 2460, 3556], 'orphan': [1009], 'named': [1011, 3552], '(9Filardo': [1013], 'Interestingly,': [1031, 3657], 'elicited': [1034], 'do': [1037], 'require': [1039], 'localization': [1043], 'at': [1044, 2377, 2489, 3184], 'membrane': [1046, 3179], 'level,': [1047], 'shown': [1049, 2158, 2370], 'contrary': [1052], 'investigations': [1055], 'various': [1057, 4193], 'types': [1059], '19Singer': [1113], 'Figueroa-Masot': [1115], 'X.A.': [1116], 'Batchelor': [1117], 'R.H.': [1118, 1181], 'Dorsa': [1119], 'D.M.': [1120], '2455-2463Crossref': [1125], '20Russell': [1129], 'K.S.': [1130], 'Haynes': [1131], 'M.P.': [1132], 'Sinha': [1133], 'Clerisme': [1135], 'Bender': [1137], 'J.R.': [1138, 1921], '5930-5935Crossref': [1148], '(336)': [1151], '21Razandi': [1154], 'Oh': [1156], 'Schnitzer': [1160], '16:': [1167], '100-115Crossref': [1168], '(298)': [1171], '22Zhu': [1174], 'Y.': [1175, 1832, 1844, 1846, 4140], 'Bian': [1176], 'Z.': [1177], 'Lu': [1178], 'Karas': [1180], 'Bao': [1182], 'Cox': [1184], 'Hodgin': [1186], 'Thoren': [1190], 'Smithies': [1192], 'O.': [1193, 3000], 'Gustafsson': [1194], 'Science.': [1198, 1979, 2013], '295:': [1200], '505-508Crossref': [1201], '(409)': [1204], '23Razandi': [1207], 'Park': [1211], 'S.T.': [1212], '278:': [1219], '2701-2712Abstract': [1220], '(413)': [1228], 'In': [1231, 2400, 2440, 3506], 'this': [1232, 2335, 4202], 'respect,': [1233], 'potential': [1235, 3660], 'trigger': [1239], 'different': [1240, 1354], 'pathways': [1241, 2041], 'integrate': [1243], 'surface': [1245], 'signaling': [1246, 2451, 2457], 'gene': [1248, 1346, 1737, 1740, 1962, 2985, 3412, 3550, 3569, 3596, 4249], 'attracted': [1251], 'increased': [1253], 'interest': [1254], 'toward': [1255], 'identification': [1257], 'agonistic': [1259], 'or': [1260, 2807, 3102], 'antagonistic': [1261], 'compounds.': [1262], 'plays': [1266], 'relevant': [1268], 'role': [1269], 'regulation': [1272], 'normal': [1274], 'growth,': [1276], 'differentiation,': [1277], 'cellular': [1279, 1748], 'transformation': [1280], 'processes': [1281], '(24Muller': [1282, 1669], 'R.': [1283, 1362, 1378, 1520, 1612, 1626, 1670, 1798, 1834, 2043, 2067, 2100, 2286, 2355, 2388, 2405, 2701, 3233, 3458, 3710, 3726, 3856, 3948, 3962, 4048, 4156, 4171], 'Biochim.': [1284, 1671], 'Biophys.': [1285, 1672, 2629], 'Acta.': [1286, 1673], '1986;': [1287, 1364, 1674, 3712], '823:': [1288, 1675], '207-225PubMed': [1289, 1676], '25Cohen': [1292, 1679], 'D.R.': [1293, 1680], 'Curran': [1294, 1310, 1681, 1697], 'Crit.': [1296, 1562, 1683, 2275, 3898], 'Oncog.': [1298, 1564, 1685, 2277, 3900], '1:': [1300, 1687, 2048], '65-88PubMed': [1301, 1688], '26Curran': [1304, 1691], 'Reddy': [1306, 1693], 'E.P.': [1307, 1397, 1694, 2188, 3745], 'Skalka': [1308, 1695], 'A.M.': [1309, 1696, 2679, 3529], 'Oncogene': [1313, 1700], 'Handbook.': [1314, 1701], 'Elsevier': [1315, 1702], 'Science': [1316, 1703], 'Publishers': [1317, 1704], 'B.V.,': [1318, 1705], 'Amsterdam1988:': [1319, 1706], '307-325Google': [1320, 1707], '27Curran': [1322, 1709], 'Franza': [1324, 1711], 'B.R.': [1326, 1713], '1988;': [1328, 1400, 1715, 2191, 3748], '55:': [1329, 1716], '395-397Abstract': [1330, 1717], '(1307)': [1336, 1723], 'Besides,': [1339], 'represents': [1341], 'prototypical': [1343], '"immediate': [1344], 'early"': [1345], 'since': [1347], 'its': [1348, 3632], 'rapidly': [1351], 'stimuli': [1356, 2035], 'including': [1357, 2131], 'mitogens': [1358], 'hormones': [1360], '(28Treisman': [1361, 3709], '46:': [1365, 3713], '567-574Abstract': [1366, 3714], '(526)': [1372, 3720], '29Fisch': [1375, 3723], 'T.M.': [1376, 3724], 'Prywes': [1377, 3725, 4155, 4170], 'Roeder': [1379, 3727], 'R.G.': [1380, 1933, 3728], '1987;': [1384, 3732], '7:': [1385, 3733], '3490-3502Crossref': [1386, 3734], '(210)': [1389, 3737], '30Wilding': [1392, 3740], 'Lippman': [1394, 2185, 3742], 'Gelmann': [1396, 2187, 3744], 'Cancer': [1398, 2045, 2189, 3259, 3746], 'Res.': [1399, 2190, 2630, 3260, 3461, 3747], '48:': [1401, 2192, 3749], '802-805PubMed': [1402, 2193, 3750], '31Shaw': [1405, 3753], 'P.E.': [1406, 3754], 'Schroter': [1407, 3755], 'H.': [1408, 1804, 1836, 1927, 3756, 4224], 'Nordheim': [1409, 3757], '56:': [1413, 3761], '563-572Abstract': [1414, 3762], '(346)': [1420, 3768], '32Van': [1423, 2196, 3771], 'der': [1424, 1492, 1532, 2197, 2221, 2245, 3772, 3828, 3868], 'Burg': [1425, 1493, 1533, 2198, 2222, 2246, 3773, 3829, 3869], 'Van': [1427, 1433, 2200, 2206, 3775, 3781], 'Selm-Miltenburg': [1428, 2201, 3776], 'A.J.P.': [1429, 2202, 3777], 'De': [1430, 1495, 1502, 1535, 1542, 2203, 2224, 2231, 2248, 2255, 3778, 3831, 3838, 3871, 3878], 'Laat': [1431, 1503, 1543, 2204, 2232, 2256, 3779, 3839, 3879], 'S.W.': [1432, 1504, 1544, 2205, 2233, 2257, 3780, 3840, 3880], 'Zoelen': [1434, 2207, 3782], 'E.J.J.': [1435, 2208, 3783], '64:': [1440, 2213, 3788], '223-228Crossref': [1441, 2214, 3789], '(125)': [1444, 2217, 3792], '33McDonnell': [1447, 3795], 'S.E.': [1448, 3796], 'Kerr': [1449, 2009, 3797], 'L.D.': [1450, 3798], 'Matrisian': [1451, 3799], 'L.M.': [1452, 3800], '1990;': [1456, 1470, 1483, 1507, 1768, 2047, 2236, 3462, 3804, 3819, 3843], '4284-4293Crossref': [1458, 3806], '(166)': [1461, 3809], '34Rivera': [1464], 'V.M.': [1465, 1476, 3812], 'Greenberg': [1466, 1479, 1574, 1934, 1977, 3815, 3910], 'New': [1468], '2:': [1471], '751-758PubMed': [1472], '35Rivera': [1475], 'Sheng': [1477, 3813], 'Genes': [1481, 3817], 'Dev.': [1482, 2071, 3278, 3818], '4:': [1484, 1508, 1566, 2073, 2237, 2279, 3820, 3844, 3902], '255-268Crossref': [1485, 3821], '(104)': [1488, 3824], '36Van': [1491, 2220, 3827], 'Groot': [1496, 1536, 2225, 2249, 3832, 3872], 'R.P.': [1497, 1537, 2226, 2250, 3833, 3873], 'Isbrücker': [1498, 2227, 3834], 'Kruijer': [1500, 1540, 2229, 2253, 3836, 3876], 'W.': [1501, 1541, 2230, 2254, 2357, 2390, 2407, 3837, 3877, 4152], '1720-1726Crossref': [1509, 2238, 3845], '(47)': [1512, 2241, 3848], '37Candeliere': [1515, 3851], 'G.A.': [1516, 3852], "Prud'homme": [1517, 3853], 'St-Arnaud': [1519, 3855], '1991;': [1523, 1550, 1787, 1807, 1823, 1980, 2263, 2317, 3859, 3886, 3992], '5:': [1524, 1824, 2087, 3860], '1780-1788Crossref': [1525, 3861], '(45)': [1528, 3864], '38Van': [1531, 2244, 3867], 'Isbrucker': [1538, 2251, 3874], '40:': [1551, 2264, 3887], '215-221Crossref': [1552, 2265, 3888], '(34)': [1555, 2268, 3891], '39Weisz': [1558, 2271, 3894], 'Bresciani': [1560, 1639, 2273, 2299, 3896, 3975], '361-388PubMed': [1567, 2280, 3903], '40Ginty': [1570, 3906], 'D.D.': [1571, 3907], 'Bonni': [1572, 3908], '77:': [1578, 3914], '713-725Abstract': [1579, 3915], '(673)': [1585, 3921], '41Lee': [1588, 3924], 'Deeds': [1590, 3926], 'J.D.': [1591, 3927], 'Chiba': [1592, 3928], 'Un-No': [1594, 3930], 'Bond': [1596, 3932], 'A.T.': [1597, 3933], 'Segre': [1598, 3934], 'G.V.': [1599, 3935], '134:': [1602, 3938], '441-450Crossref': [1603, 3939], '(184)': [1606, 3942], '42Hill': [1609, 3945], 'C.S.': [1610, 3946], 'Treisman': [1611, 3947, 4047], '1995;': [1615, 1871, 2086, 2103, 3951, 4035], '5037-5047Crossref': [1617, 3953], '(209)': [1620, 3956], '43Bonapace': [1623, 2283, 3959], 'I.M.': [1624, 2010, 2284, 3960], 'Addeo': [1625, 2285, 3961], 'Altucci': [1627, 2287, 3963], 'Cicatiello': [1629, 2289, 3965], 'Bifulco': [1631, 2291, 3967], 'Laezza': [1633, 2293, 3969], 'Salzano': [1635, 2295, 3971], 'Sica': [1637, 2297, 3973], 'Weisz': [1641, 2301, 3977], 'Oncogene.': [1643, 2303, 2680, 3530, 3979], '12:': [1645, 2305, 3981], '753-763PubMed': [1646, 2306, 3982], 'nuclear': [1650, 3543], 'encoded': [1652, 3545], 'interacts': [1655], 'c-jun': [1657], 'family': [1658], 'members': [1659, 1881], 'form': [1661], 'heterodimeric': [1663], 'activating': [1664, 1731], 'protein-1': [1665, 1732], 'factor': [1667, 2135, 3563], 'fos-jun': [1727], 'heterodimers': [1728], 'sites': [1733, 1894], 'within': [1735, 2334], 'mammalian': [1736], 'promoters': [1738], 'regulates': [1739, 3567], 'depending': [1746], 'promoter': [1750, 3442, 3590, 3672], 'context': [1751], 'interacting': [1755], 'proteins': [1756], '(44Gaub': [1757], 'Bellard': [1759], 'Scheuer': [1761], 'I.': [1762, 2665, 3515], 'Chambon': [1763], 'Sassone-Corsi': [1765, 1799, 4094], '1267-1276Abstract': [1770], '(417)': [1776], '45Doucas': [1779, 2309], 'Spyrou': [1781, 2311, 3986], 'Yaniv': [1783, 2313, 3988], '2237-2245Crossref': [1789, 2319, 3994], '(106)': [1792, 2322, 3997], '46Shemshedini': [1795], 'Knauthe': [1797], 'Pornon': [1801], 'Gronemeyer': [1803], '3839-3849Crossref': [1809], '(170)': [1812], '47Tzukerman': [1815], 'Zhang': [1817], 'Pfahl': [1819], '1983-1992Crossref': [1825], '(79)': [1828], '48Umayahara': [1831], 'Kawamori': [1833], 'Watada': [1835], 'Imano': [1837], 'Iwama': [1839], 'N.': [1840, 3307], 'Morishima': [1841], 'Yamasaki': [1843], 'Kajimoto': [1845], 'Kamada': [1847], '269:': [1853], '16433-16442Abstract': [1854], '49Webb': [1861], 'Lopez': [1863], 'G.N.': [1864], 'Uht': [1865], 'R.M.': [1866], 'Kuchner': [1867], 'P.J.': [1868], '9:': [1872, 4162], '443-456Crossref': [1873], 'Moreover,': [1877], 'fos': [1884], 'family,': [1885], 'fosB,': [1888], 'fra-1,': [1889], 'fra-2,': [1891], 'identified': [1895], 'regulatory': [1898], 'region': [1899, 2179, 3676], 'modulating': [1903], 'late': [1905], 'critical': [1909], 'cycle': [1913], 're-entry,': [1914], 'cyclin': [1917], 'D1': [1918], '(Ref.': [1919], '50Brown': [1920], 'Nigh': [1922], 'Lee': [1924, 4168], 'R.J.': [1925], 'Ye': [1926], 'Thompson': [1928, 1975], 'M.A.': [1929, 1976, 4044], 'Saudou': [1930], 'Pestell': [1932], '1998;': [1939, 2361, 2394, 3244, 4103, 4126, 4161], '18:': [1940, 3463], '5609-5619Crossref': [1941], '(205)': [1944], 'Scholar': [1946], 'references': [1948], 'therein).': [1949], 'controlled': [1955], 'cis-elements': [1958], 'present': [1959, 3431], 'promoter:': [1963], 'cAMP-response': [1965, 1970], 'element': [1966, 2024, 2113, 2332], 'binds': [1968, 2115], 'element-binding': [1971], '(51Sheng': [1973], '252:': [1981], '1427-1430Crossref': [1982], '(1268)': [1985], 'Sis-inducible': [1989], 'enhancer': [1990], 'signal': [1996], 'transducers': [1997], 'activators': [1999], '(STAT)': [2002], 'group': [2003], '(52Darnell': [2007], 'J.E.': [2008], 'Stark': [2011], 'G.R.': [2012], '264:': [2015], '1415-1421Crossref': [2016], '(4912)': [2019], 'serum-response': [2023, 2112, 2120, 2134, 2438, 2467], 'mediates': [2026], 'induction': [2028, 4350], 'factors,': [2031], 'leading': [2036], 'MAPK': [2040, 2456, 3489], '(53Treisman': [2042], 'Semin.': [2044], '47-58PubMed': [2049], '54Karin': [2052], 'Curr.': [2054, 2068, 2084, 2143], 'Opin.': [2055, 2069, 2144], '6:': [2059, 2148], '415-424Crossref': [2060, 2149], '(359)': [2063, 2152], '55Treisman': [2066], 'Genet.': [2070], '96-101Crossref': [2074], '(618)': [2077], '56Karin': [2080], 'Hunter': [2082], '747-757Abstract': [2088], '(656)': [2096], '57Treisman': [2099], '4905-4913Crossref': [2105], '(345)': [2108], 'initially': [2114], 'dimer': [2117], 'factor,': [2121], 'recruits': [2126], 'ternary': [2128, 3561], 'Elk-1': [2132, 2464, 3626], 'accessory': [2136], '1': [2138, 2915, 3121, 3137, 4259], '2': [2140, 2892, 3101], '(54Karin': [2141], 'Several': [2155], 'studies': [2156], 'also': [2161, 4343], 'activates': [2162], 'hormone-sensitive': [2172], 'site': [2173, 2380], 'localized': [2175], '240-bp': [2178], '(–1300': [2180], '–1060)': [2182], '(30Wilding': [2183], 'Further': [2325], 'analysis': [2326, 3347, 3351], 'demonstrated': [2327, 3407], 'imperfect': [2329, 2384], 'palindromic': [2330, 2385], '(ERE)': [2333], 'sequence': [2336], 'able': [2339, 2505], 'gel': [2344], 'mobility': [2345], 'shift': [2346], 'assays': [2347], 'sufficient': [2351], 'transactivation': [2353, 3580, 3624], '(58Duan': [2354, 2387], 'Porter': [2356, 2389], 'Safe': [2358, 2391, 2410], '139:': [2362, 2395], '1981-1990Crossref': [2363, 2396], 'Thereafter,': [2367], 'was': [2369, 2719, 2844, 2862, 2901, 2930, 2980, 2987, 3151, 3338, 3348, 3366, 3611, 3664, 4354], 'must': [2373], 'interact': [2374], 'Sp1': [2376], 'GC-rich': [2379], 'downstream': [2381], 'from': [2382, 2537, 2549, 2617, 2736, 2748, 2966, 3289], 'ERE': [2386, 2603, 3410, 3675], 'subsequent': [2402], 'study': [2403, 2659, 3384], '(59Duan': [2404], 'Xie': [2406], 'Burghardt': [2408], 'R.C.': [2409], '11590-11598Abstract': [2417], '(129)': [2425], 'seem': [2433], 'converge': [2435], 'element.': [2439, 2468], 'latter': [2442, 2648], 'case,': [2443], 'however,': [2444], 'involved': [2449], 'non-genomic': [2450], 'Herein,': [2469], 'show': [2471], 'quercetin': [2486, 3476, 4342], 'mediated': [2488], 'least': [2490], 'part': [2492], 'cells.': [2499, 4334], 'However,': [2500], 'same': [2502, 4275], 'agents': [2503], 'are': [2504], 'Reagents—17β-estradiol,': [2521], 'genistein,': [2522, 4340], '4-hydroxytamoxifen,': [2524], 'cycloheximide,': [2525], 'wortmannin,': [2526], 'toxin,': [2528], 'PD': [2529, 2578, 3491, 3642], '98059,': [2530, 2579], 'LY': [2531, 2581, 3502], '294002,': [2532, 2582, 3503], 'dexamethasone,': [2533], 'progesterone': [2534], 'were': [2535, 2547, 2569, 2584, 2593, 2651, 2697, 2733, 2747, 2757, 2777, 2793, 2826, 2923, 2946, 2969, 3091, 3168, 3222, 4277], 'purchased': [2536, 3288], 'Sigma.': [2538], 'R1881,': [2539], 'ICI': [2540], '182780,': [2541], 'tyrphostin': [2542], 'AG': [2543], '1478,': [2544], 'PP2': [2546], 'obtained': [2548, 2965, 4278], 'AstraZeneca': [2550], '(Milan,': [2551], 'Italy),': [2552, 2563], 'Tocris': [2553], 'Chemicals': [2554], '(Bristol,': [2555], 'UK),': [2556], 'Biomol': [2557], 'Research': [2558], 'Laboratories,': [2559], 'Inc': [2560], '(DBA,': [2561], 'Milan,': [2562, 2717, 3207], 'Calbiochem,': [2565], 'respectively.': [2566, 3088], 'All': [2567], 'compounds': [2568, 3484, 3584, 3663], 'solubilized': [2570], 'dimethyl': [2572], 'sulfoxide,': [2573], 'except': [2574], 'hydroxytamoxifen': [2576], '(OHT),': [2577], 'dissolved': [2585], 'ethanol.': [2587], 'Plasmids—The': [2588], 'firefly': [2589], 'luciferase': [2590, 2712, 2935, 2944, 2957, 3606], 'reporter': [2591, 2882, 3411, 3595], 'plasmids': [2592, 2650], 'deletion': [2597], 'mutant': [2598, 3668], 'c-fosΔERE': [2599], '(which': [2600], 'lacks': [2601], 'sequence)': [2604], 'encoding': [2605, 4250], '–2.2-kb': [2606], '–1172-bp': [2608], '5′': [2609], 'upstream': [2610], 'fragments': [2611], 'human': [2613, 2729, 2743, 3440], 'c-fos,': [2614, 3014, 3191], 'respectively': [2615], '(gifts': [2616], 'Nose,': [2619], 'Tokyo,': [2620], 'Japan)': [2621], '(60Kim-Kaneyama': [2622], 'Shibanuma': [2624], 'Nose': [2626], 'Comm.': [2631], '299:': [2633], '360-365Crossref': [2634], '(30)': [2637], 'Scholar)': [2639, 3286, 4184], 'Gal4-luc': [2641], 'Gal4-Elk1': [2644], 'fusion': [2645], 'protein.': [2646], 'described': [2652, 2996, 3225, 3343], 'together': [2653], 'menin': [2655, 3577, 3617], 'our': [2657, 3382, 3507], 'previous': [2658, 3383, 3508], '(61Gallo': [2660, 3510], 'Cuozzo': [2662, 3512], 'Esposito': [2664, 3514], 'Garriamone': [2672, 3522], 'Weiss': [2674, 3524], 'Bohmann': [2676, 3526], 'Musti': [2678, 3528], '6434-6445Crossref': [2683, 3533], '(76)': [2686, 3536], 'negative': [2692], 'ERK2': [2693, 3201], '(DN/ERK2)': [2694], 'vectors': [2696], 'kindly': [2698], 'provided': [2699, 2953], 'Weigel': [2702], '(Philadelphia,': [2703, 2739], 'PA)': [2704], 'Cobb': [2707], '(Dallas,': [2708], 'TX).': [2709], 'Renilla': [2711, 2956], 'vector': [2714], 'pRL-TK': [2715], '(Promega,': [2716], 'Italy)': [2718, 3208], 'transfection': [2723, 2951], 'standard.': [2724], 'Culture—MCF7,': [2726], 'MDA-MB-231,': [2727], 'gift': [2735], 'Surmacz': [2738], 'PA),': [2740], 'whereas': [2741, 2774, 3637, 4288], "Picard's": [2749], 'laboratory': [2750], '(Genève,': [2751], 'Switzerland).': [2752], 'MDA-MB-231': [2755], 'maintained': [2758, 2778, 3665], "Dulbecco's": [2760, 2847, 2906], 'modified': [2761, 2848, 2907], "Eagle's": [2762, 2849, 2908], 'medium/F12': [2763, 2850], 'without': [2764, 2782, 2797], 'phenol': [2765, 2783, 2852, 2911], 'red': [2766, 2784, 2853, 2912], 'supplemented': [2767, 2785], '10%': [2769, 2787, 3124, 3172], 'fetal': [2770, 2788], 'bovine': [2771, 2789], 'serum': [2772, 2790, 2798, 2855], '(Invitrogen),': [2773], 'RPMI': [2780], '1640': [2781], '(Invitrogen).': [2791], 'Cells': [2792], 'switched': [2794], 'medium': [2796, 2843, 2900, 2909], '24': [2799], 'h': [2800, 2804, 2810, 3104, 4260], 'before': [2801, 2805, 2811, 2840, 3105], 'transfections,': [2802], '48': [2803], 'RT-PCR': [2806, 2991, 4239], 'immunoblot,': [2808], '72': [2809], 'evaluation': [2813, 2983], 'ERK1/ERK2': [2815], 'phosphorylation.': [2816], 'Transfections': [2817], 'Luciferase': [2819, 2928], 'Assays—A': [2820], 'total': [2821], '100,000': [2823], 'plated': [2827], 'into': [2828], '24-well': [2829], 'dishes': [2830, 3095], '500': [2832, 3108], 'μl': [2833], 'regular': [2835], 'medium/well': [2837], 'day': [2839, 2858], 'transfection.': [2841], 'replaced': [2845, 2902], 'lacking': [2851, 2910, 3673], 'transfection,': [2860], 'performed': [2863, 2988, 3349, 4236], 'using': [2864, 3212, 3350, 3585, 3666], 'FuGENE': [2865], '6': [2866], 'reagent': [2867, 3155], 'recommended': [2869], 'manufacturer': [2872], '(Roche': [2873], 'Diagnostics)': [2874], 'mixture': [2877, 3132], 'containing': [2878, 2914, 3136], '0.5': [2879], 'μg': [2880, 2885], 'plasmid,': [2883], '0.1': [2884], 'effector': [2887], 'plasmid': [2888], 'where': [2889], 'applicable,': [2890], 'ng': [2893], 'pRLCMV.': [2895], 'After': [2896], '4': [2897, 3185], 'h,': [2898], 'again': [2903], 'serum-free': [2905], 'μm': [2916], 'each': [2918], 'treatment,': [2919], 'then': [2921, 3210], 'incubated': [2924], '5': [2926], 'h.': [2927], 'activity': [2929, 2976, 3607], 'measured': [2931], 'dual': [2934], 'kit': [2936], '(Promega)': [2937], 'according': [2938, 3156], "manufacturer's": [2941, 3159], 'recommendations.': [2942], 'Firefly': [2943], 'values': [2945, 2964], 'normalized': [2947, 2960], 'internal': [2950], 'control': [2952, 3025, 3305], 'activity.': [2958, 3479], 'relative': [2961], 'light': [2962], 'unit': [2963], 'untreated': [2967, 4296], 'set': [2970], '100%,': [2972], 'upon': [2973], 'treatments': [2979], 'calculated.': [2981], 'RT-PCR—The': [2982], 'semiquantitative': [2990, 4238], 'previously': [2995, 3452], '(62Maggiolini': [2997], 'Donzè': [2999], '380:': [3006], '695-697Crossref': [3007], '(35)': [3010], 'pS2,': [3015], 'cathepsin': [3016, 4217, 4282], 'D,': [3017], 'GPR30,': [3019], '36B4': [3021], 'gene,': [3026], 'primers': [3028], 'were:': [3029, 3296], '5′-CCAACTTCATTCCCACGGTCAC-3′': [3030], '(c-fos': [3031, 3035], 'forward)': [3032, 3039, 3047, 3055, 3062], '5′-TGGCAATCTCGGTCTGCAAA-3′': [3034], 'reverse);': [3036, 3043, 3052, 3059], '5′-TTCTATCCTAATACCATCGACG-3′': [3037], '(pS2': [3038, 3042], '5′-TTTGAGTAGTCAAAGTCAGAGC-3′': [3041], '5′-AACAACAGGGTGGGCTTC-3′': [3044], '(cathepsin': [3045, 3050], 'D': [3046, 3051, 4218, 4283], '5′-ATGCACGAAACAGATCTGTGCT-3′': [3049], '5′-CTGGGGAGTTTCCTGTCTGA-3′': [3053], '(GPR30': [3054, 3058], '5′-GCTTGGGAAGTCACATCCAT-3′': [3057], '5′-CTCAACATCTCCCCCTTCTC-3′': [3060], '(36B4': [3061, 3065], '5′-CAAATCCCATATCCTCGTCC-3′': [3064], 'reverse),': [3066], 'yield': [3068], 'products': [3069], '381,': [3071], '303,': [3072], '210,': [3073], '155': [3074], '408': [3076], 'bp,': [3077], 'respectively,': [3078], '20,': [3080, 3082, 3083], '13,': [3081], '13': [3085], 'PCR': [3086], 'cycles,': [3087], 'Western': [3089], 'Blotting—Cells': [3090], 'grown': [3092], '10-cm': [3094], 'exposed': [3097], 'ligands': [3099], '12': [3103], 'lysis': [3106], 'μlof': [3109], '50': [3110], 'mm': [3111, 3116, 3119, 3122, 3138, 3141], 'HEPES': [3112], '(pH': [3113], '7.5),': [3114], '150': [3115], 'NaCl,': [3117], '1.5': [3118], 'MgCl2,': [3120], 'EGTA,': [3123], 'glycerol,': [3125], '1%': [3126, 3129], 'Triton': [3127], 'X-100,': [3128], 'SDS,': [3130], 'protease': [3134], 'inhibitors': [3135], 'aprotinin,': [3139], '20': [3140], 'phenylmethylsulfonyl': [3142], 'fluoride,': [3143], '0.2': [3145], 'm': [3146], 'sodium': [3147], 'orthovanadate.': [3148], 'Protein': [3149, 4306], 'concentration': [3150, 3330], 'determined': [3152], 'Bradford': [3154], 'recommendations': [3160], '(Sigma).': [3161], 'Equal': [3162], 'amounts': [3163], 'whole': [3165], 'extract': [3167], 'resolved': [3169], 'SDS-polyacrylamide': [3173], 'gel,': [3174], 'transferred': [3175], 'nitrocellulose': [3178], '(Amersham': [3180, 3216], 'Biosciences),': [3181], 'probed': [3182], 'overnight': [3183], '°C': [3186], 'antibodies': [3189], 'β-actin': [3192], '(Santa': [3193], 'Cruz': [3194], 'Biotechnology,': [3195], 'Santa': [3196], 'Cruz,': [3197], 'CA),': [3198], 'pERK1/2,': [3200], '(Cell': [3202], 'Signaling': [3203], 'Technology,': [3204], 'Inc,': [3205], 'Celbio,': [3206], 'revealed': [3211], 'ECL': [3214], 'system': [3215], 'Biosciences).': [3217], 'Antisense': [3218, 3274], 'Oligodeoxynucleotide': [3219], 'Experiments—Antisense': [3220], 'oligonucleotides': [3221, 3294, 3337], 'synthesized': [3223], "(63O'Dowd": [3226], 'B.F.': [3227], 'Nguyen': [3228], 'T': [3229], 'Marchese': [3230], 'Cheng': [3232], 'Lynch': [3234], 'K.R.': [3235], 'Heng': [3236], 'H.H.': [3237], 'Kolakowski': [3238], 'L.F.': [3240], 'George': [3241], 'S.R.': [3242], 'Genomics.': [3243], '37:': [3245], '310-313Crossref': [3246], '(248)': [3248], '64Lau': [3251], 'K.-M.': [3252], 'LaSpina': [3253], 'Long': [3255], 'Ho': [3257, 4065], 'S.-M.': [3258], '3175-3182PubMed': [3263], '65Taylor': [3266], 'A.H.': [3267], 'Pringle': [3268], 'J.H.': [3269], 'Bell': [3270], 'Al-Azzawi': [3272], 'Nucleic': [3275, 3459], 'Acid': [3276], 'Drug': [3277], '11:': [3280], '219-231Crossref': [3281], '(10)': [3284], 'MWG': [3290], '(Florence,': [3291], 'Italy).': [3292], '5′-TTGGGAAGTCACATCCAT-3′': [3297], 'GPR30;': [3299], '5′-GATCTCAGCACGGCAAAT-3′': [3301], 'scrambled': [3304], '(66Kanda': [3306], 'Watanabe': [3308], 'Investig.': [3311], 'Dermatol.': [3312], '121:': [3314], '771-780Abstract': [3315], '(63)': [3323, 4084], 'experiments,': [3328], '200': [3332], 'nm': [3333], 'indicated': [3336, 3644], 'following': [3340], 'procedure': [3342], 'above.': [3344], 'Statistical': [3345], 'Analysis—Statistical': [3346], 'variance': [3353], 'followed': [3354], 'Newman-Keuls': [3356], 'testing': [3357], 'determine': [3359], 'differences': [3360], 'means.': [3362], 'p': [3363], '<': [3364], '0.05': [3365], 'considered': [3367], 'statistically': [3369], 'significant.': [3370], 'Genistein,': [3372, 3693, 4301], 'Quercetin': [3374, 3695, 4303], 'Transactivate': [3375], 'Promoter': [3377], 'Constructs': [3378], 'Cells—In': [3381], '(4Maggiolini': [3385], 'responds': [3417], 'like': [3422], 'ERα-mediated': [3426], 'mechanism.': [3427], 'Thus,': [3428], 'study,': [3432], 'first': [3434], 'examined': [3435], 'whether': [3436, 4197, 4317], 'transiently': [3437], 'full-length': [3439], '(–2.2': [3443], 'kb)': [3444], 'could': [3445], 'respond': [3446], 'these': [3448, 3662], 'reported': [3451, 3708], '(67Weisz': [3455], 'Rosales': [3457], 'Acids': [3460], '5097-5106Crossref': [3464], '(267)': [3467], 'Fig.': [3470], '1A': [3471], 'demonstrates': [3472], 'mirror': [3477], 'Activation': [3480], 'all': [3482], 'three': [3483], 'sensitive': [3486], 'inhibitor': [3490, 3499], '98059': [3492, 3643], 'unaffected': [3495], 'PI3K': [3498], 'wortmannin': [3500], '(or': [3501], 'shown).': [3505], 'investigation': [3509], 'showed': [3540], 'tumor': [3548], 'suppressor': [3549], 'MEN1,': [3551], 'menin,': [3553], 'inhibits': [3554], 'ERK-dependent': [3555], 'member': [3564], 'Elk-1,': [3565], 'expression.': [3570], 'Therefore,': [3571], 'evaluated': [3573], 'property': [3581], 'estrogenic': [3583], 'above': [3587], 'mentioned': [3588], 'assay': [3591, 3597], 'corresponding': [3594], 'monitoring': [3599], 'Gal4-Elk-1.': [3603], 'As': [3604], 'expected,': [3605], 'constructs': [3610], 'reversed': [3612], 'presence': [3615], '(Fig.': [3618, 3655, 4272, 4298, 4351], '1,': [3619], 'B).': [3622], 'confirmed': [3631], 'involvement': [3633], 'expression,': [3636], 'inhibitory': [3639], 'MAPK-dependent': [3647], 'mechanism': [3648], 'required': [3650], '1B).': [3656], '(–1172': [3677], 'bp),': [3678], 'suggesting': [3679], 'pathways,': [3682], 'requiring': [3684], 'ERα-ERE': [3686], 'interaction,': [3687], 'contribute': [3688], 'transactivation.': [3691], 'Rapidly': [3696], 'Induce': [3697], 'mRNA': [3699, 4242, 4323], 'Expression': [3700], 'Cells—It': [3704], 'largely': [3707], 'Scholar,35Rivera': [3811], 'Scholar,45Doucas': [3984], '69Meyer': [4000], 'Stephenson': [4002], 'E.W.': [4003], 'Johnson': [4004], 'Cochran': [4006], 'B.H.': [4007], 'Schwartz': [4008, 4069, 4121], '90:': [4018], '6721-6725Crossref': [4019], '(72)': [4022], '70Cavigelli': [4025], 'Dolfi': [4027], 'Claret': [4029], 'F.X.': [4030], 'Karin': [4031], '5957-5964Crossref': [4037], '(483)': [4040], '71Price': [4043], 'Cruzalegui': [4045], 'F.H.': [4046], '6552-6563Crossref': [4053], '(300)': [4056], '72Liao': [4059], 'Hodge': [4061], 'Meyer': [4063], 'P.S.': [4066], 'Rosenspire': [4067], '272:': [4075], '25951-25958Abstract': [4076], '73De': [4087], 'Cesare': [4088], 'Jacquot': [4090], 'Hanauer': [4092], '95:': [4104], '12202-12207Crossref': [4105], '(259)': [4108], '74Hodge': [4111], 'Liao': [4113], 'Stofega': [4115], 'Carter-Su': [4119], '273:': [4127], '31327-31336Abstract': [4128], '(229)': [4136], '75Wang': [4139], 'Falasca': [4141], 'Schlessinger': [4143], 'Malstrom': [4145], 'Tsichlis': [4147], 'Settleman': [4149], 'Lim': [4153], 'Growth': [4158], '&': [4159], 'Differ.': [4160], '513-522PubMed': [4163], '76Soh': [4166], 'E.H.': [4169], 'I.B.': [4173], '1313-1324Crossref': [4179], '(246)': [4182], 'promptly': [4188], 'stimulated': [4189], 'agents.': [4194], 'To': [4195], 'evaluate': [4196, 4316], 'mimic': [4199], 'regard': [4203], 'known': [4212], 'pS2': [4215, 4280], '(77Cavailles': [4219], 'Garcia': [4221], 'Rochefort': [4223], '3:': [4228], '552-558Crossref': [4229], '(163)': [4232], 'comparing': [4240], 'levels': [4243, 4292, 4320], 'after': [4244, 4326], 'standardization': [4245], 'housekeeping': [4248], 'ribosomal': [4252], '36B4.': [4254], 'treatment': [4256, 4330], 'only': [4258], 'up-regulated': [4265], '2A).': [4273], 'results': [4276, 4312], '12-h': [4286], 'exposure,': [4287], 'returned': [4290], 'resembling': [4293], '2B).': [4299], 'Up-regulate': [4304], 'Levels': [4307], 'Cells—The': [4310], 'aforementioned': [4311], 'prompted': [4313], 'us': [4314], 'follow': [4321], 'increase': [4324], 'observed': [4325], 'short': [4328], '(2-h)': [4329], 'similar': [4336], 'exposure': [4337], 'resulted': [4344], 'significant': [4347], '3A)': [4352], 'dependent': [4355], 'pro': [4357]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028893107', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 32}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 31}], 'updated_date': '2024-12-08T02:08:37.281713', 'created_date': '2016-06-24'}
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