Title: Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the PΩ peptide motif
Abstract: Tissue AntigensVolume 76, Issue 6 p. 487-490 Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the PΩ peptide motif N. E. Elamin, N. E. Elamin Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this authorC. Bade-Doeding, C. Bade-Doeding Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this authorR. Blasczyk, Corresponding Author R. Blasczyk Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanyProfessor Dr Rainer BlasczykInstitute for Transfusion MedicineHannover Medical SchoolCarl-Neuberg-Strasse 130625 HannoverGermanyTel: +49 511 532 6700Fax: +49 511 532 2079e-mail: [email protected]Search for more papers by this authorB. Eiz-Vesper, B. Eiz-Vesper Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this author N. E. Elamin, N. E. Elamin Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this authorC. Bade-Doeding, C. Bade-Doeding Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this authorR. Blasczyk, Corresponding Author R. Blasczyk Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanyProfessor Dr Rainer BlasczykInstitute for Transfusion MedicineHannover Medical SchoolCarl-Neuberg-Strasse 130625 HannoverGermanyTel: +49 511 532 6700Fax: +49 511 532 2079e-mail: [email protected]Search for more papers by this authorB. Eiz-Vesper, B. Eiz-Vesper Institute for Transfusion Medicine, Hannover Medical School, Hannover, GermanySearch for more papers by this author First published: 08 November 2010 https://doi.org/10.1111/j.1399-0039.2010.01547.xCitations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The human leukocyte antigen (HLA)-A*03 group has more than 90 known members and is one of the largest families of HLA class I alleles, with the most common variant being HLA-A*0301. In this study, we determined the peptide-binding motif of the highly frequent Sudanese allele A*0302 and compared it with the previously published peptide-binding motif of A*0301. The two alleles differ only at two distinct residues Glu152Val and Leu156Gln, which are predicted to be part of specificity pockets D, C and E and thus in contact with the peptide. Soluble recombinant A*0302 was expressed, affinity purified and the bound peptides were then eluted and analysed by mass spectrometry. The peptide-binding motif of A*0302 differs significantly from the previously published HLA-A*0301 and the Glu152Val/Leu156Gln mismatches appear to have a significant impact on the peptide-binding features of A*0302 and A*0301. Citing Literature Volume76, Issue6December 2010Pages 487-490 RelatedInformation
Publication Year: 2010
Publication Date: 2010-11-08
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 10
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