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381, 397, 407, 415, 451, 468, 476, 515, 531, 541, 549, 580, 590, 598, 621, 631, 639, 662, 672, 680, 703, 713, 721, 744, 754, 762, 785, 801, 811, 819], 'France': [48, 65, 112, 128, 138, 146, 177, 187, 218, 228, 259, 269, 300, 310, 341, 351, 382, 398, 408, 416, 452, 469, 516, 532, 542, 550, 581, 591, 622, 632, 663, 673, 704, 714, 745, 755, 786, 802, 812, 820], 'Faculté': [49, 66, 139, 188, 229, 270, 311, 352, 409, 453, 470, 543, 592, 633, 674, 715, 756, 813], 'Pharmacie,': [51, 455], 'Université': [52, 69, 142, 147, 191, 232, 273, 314, 355, 412, 417, 456, 473, 546, 551, 595, 636, 677, 718, 759, 816, 821], 'Saint-Joseph,': [53, 457], 'Beirut,': [54, 458], 'Lebanon': [55, 459], 'Hôpital': [56, 120, 129, 178, 219, 260, 301, 342, 390, 399, 460, 524, 533, 582, 623, 664, 705, 746, 794, 803], 'Necker-Enfants': [57, 79, 130, 179, 220, 261, 302, 343, 400, 461, 483, 534, 583, 624, 665, 706, 747, 804], 'Malades,': [58, 131, 180, 221, 262, 303, 344, 401, 462, 535, 584, 625, 666, 707, 748, 805], 'Assistance': [59, 122, 132, 181, 222, 263, 304, 345, 392, 402, 463, 526, 536, 585, 626, 667, 708, 749, 796, 806], 'Publique–Hôpitaux': [60, 123, 133, 182, 223, 264, 305, 346, 393, 403, 464, 527, 537, 586, 627, 668, 709, 750, 797, 807], 'Paris': [62, 70, 86, 125, 135, 143, 184, 192, 225, 233, 266, 274, 307, 315, 348, 356, 395, 405, 413, 466, 474, 490, 529, 539, 547, 588, 596, 629, 637, 670, 678, 711, 719, 752, 760, 799, 809, 817], '(AP-HP),': [63, 126, 136, 185, 226, 267, 308, 349, 396, 406, 467, 530, 540, 589, 630, 671, 712, 753, 800, 810], 'Médecine,': [68, 141, 190, 231, 272, 313, 354, 411, 472, 545, 594, 635, 676, 717, 758, 815], 'Descartes,': [71, 144, 193, 234, 275, 316, 357, 414, 475, 548, 597, 638, 679, 720, 761, 818], 'FranceINSERM': [73, 477], 'Clinique': [75, 479], 'Maurice': [76, 480], 'Lamy,': [77, 481], 'hôpital': [78, 482], 'malades,': [80, 484], '149,': [81, 485], 'rue': [82, 486], 'Sèvres,': [84, 488], '75743': [85, 489], 'Cedex': [87, 491], '15,': [88, 492], 'FranceSearch': [89, 154, 195, 236, 277, 318, 359, 424, 493, 558, 599, 640, 681, 722, 763, 828], 'for': [90, 155, 196, 237, 278, 319, 360, 425, 494, 559, 600, 641, 682, 723, 764, 829, 1355, 1730, 2593, 2742, 2771, 3233, 3955, 4062, 4109, 4268, 4294], 'more': [91, 156, 197, 238, 279, 320, 361, 426, 495, 560, 601, 642, 683, 724, 765, 830], 'papers': [92, 157, 198, 239, 280, 321, 362, 427, 496, 561, 602, 643, 684, 725, 766, 831], 'by': [93, 158, 199, 240, 281, 322, 363, 428, 497, 562, 603, 644, 685, 726, 767, 832, 844, 998, 1459, 1834, 1926, 2258, 2444, 2449, 2455, 2775, 2865, 2912, 3044, 3180, 3498, 4278], 'this': [94, 159, 200, 241, 282, 323, 364, 429, 498, 563, 604, 645, 686, 727, 768, 833, 902, 1027, 1065, 4253], 'authorJean-Pierre': [95, 499], 'Rabès,': [96, 500], 'Jean-Pierre': [97, 501], 'Rabès': [98, 502], 'Laboratoire': [113, 383, 517, 787], 'Biochimie': [115, 385, 519, 789], 'Génétique': [118, 388, 522, 792], 'Moléculaire,': [119, 389, 523, 793], 'Ambroise-Paré,': [121, 391, 525, 795], 'Versailles–Saint-Quentin-en-Yvelines,': [148, 418, 552, 822], 'UFR': [149, 419, 553, 823], 'Paris-Ile-de-France': [151, 421, 555, 825], 'Ouest,': [152, 422, 556, 826], 'Boulogne,': [153, 423, 557, 827], 'authorMartine': [160, 564], 'Devillers,': [161, 565, 4027], 'Martine': [162, 566], 'Devillers': [163, 567, 1146, 1302, 3710], 'authorArnold': [201, 605], 'Munnich,': [202, 606], 'Arnold': [203, 607, 2611], 'Munnich': [204, 608], 'authorDanièle': [242, 646], 'Erlich,': [243, 647], 'Danièle': [244, 648], 'Erlich': [245, 649, 1154, 3712], 'authorClaudine': [283, 687], 'Junien,': [284, 688], 'Claudine': [285, 689], 'Junien': [286, 690, 1182, 1314, 3728, 4053], 'authorMathilde': [324, 728], 'Varret,': [325, 729], 'Mathilde': [326, 730], 'Varret': [327, 731, 1138, 1207, 1234, 1316, 1391, 3456, 3704, 4015], 'authorCatherine': [365, 769], 'Boileau,': [366, 770], 'Catherine': [367, 771], 'Boileau': [368, 772, 1186, 1205, 1232, 1318, 1405, 3458, 3730, 4055], 'author': [430, 834, 4293], 'First': [835], 'published:': [836], '20': [837], 'March': [838], '2009': [839], 'https://doi.org/10.1002/humu.20882Citations:': [840], '184': [841], '†': [842], 'Communicated': [843], 'William': [845], 'Oetting': [846], 'AboutPDF': [847], 'ToolsRequest': [848], 'permissionExport': [849], 'citationAdd': [850], 'to': [851, 873, 896, 1074, 1213, 1498, 1898, 2216, 2586, 2704, 3236, 3282, 3437, 3472, 3650, 4067, 4178, 4290], 'favoritesTrack': [852], 'citation': [853], 'ShareShare': [854], 'Give': [855], 'accessShare': [856, 859], 'full': [857], 'text': [858], 'full-text': [860, 875, 899], 'accessPlease': [861], 'review': [862], 'our': [863], 'Terms': [864, 887], 'Conditions': [866, 889], 'of': [867, 877, 890, 901, 916, 920, 953, 957, 991, 1001, 1016, 1024, 1046, 1084, 1128, 1327, 1334, 1465, 1521, 1524, 1550, 1595, 1631, 1638, 1686, 1738, 1766, 1892, 1999, 2058, 2097, 2100, 2154, 2290, 2298, 2319, 2347, 2405, 2440, 2491, 2550, 2589, 2657, 2673, 2700, 2707, 2746, 2811, 2819, 2858, 2860, 2939, 3009, 3049, 3065, 3092, 3097, 3211, 3383, 3430, 3492, 3533, 3537, 3572, 3582, 3609, 3617, 3677, 3739, 3743, 3756, 3957, 3967, 4113, 4172, 4184, 4220, 4227, 4252, 4273], 'Use': [868], 'check': [870], 'box': [871], 'below': [872, 895], 'share': [874, 897], 'version': [876, 900, 4251], 'article.I': [878], 'have': [879, 937, 987], 'read': [880], 'accept': [882], 'Wiley': [884], 'Online': [885], 'Library': [886], 'UseShareable': [891], 'LinkUse': [892], 'link': [894], 'a': [898, 999, 1014, 1021, 1071, 1125, 1215, 1726, 1927, 1937, 2261, 2299, 2320, 2450, 2533, 2597, 2654, 3071, 3101, 3433, 3535, 3752, 4007, 4105, 4146, 4228], 'article': [903], 'with': [904, 1013, 1055, 1285, 1492, 2028, 2062, 2106, 2414, 2497, 2629, 2653, 2901, 2966, 3138, 3338, 3785, 4141], 'your': [905], 'friends': [906], 'colleagues.': [908], 'Learn': [909], 'more.Copy': [910], 'URL': [911], 'Abstract': [912], 'Hypercholesterolemia': [913], 'is': [914, 1124, 1282, 1457, 1725, 1832, 1924, 2026, 2446, 2526, 3230, 3783, 4139, 4265], 'one': [915], 'major': [918, 3754, 4060], 'causes': [919], 'coronary': [921, 1356, 1739, 1800, 2284], 'heart': [922, 1357, 1801, 2285], 'disease': [923, 1358], '(CHD).': [924], 'The': [925, 1452, 2019, 2402, 2521, 2671, 3380, 3530, 3778, 3884, 4101, 4134, 4263], 'genes': [926, 941, 3042, 3578, 3747], 'encoding': [927, 1966], 'low-density': [929, 1002, 1732, 2108, 2708, 2867, 3072, 3833], 'lipoprotein': [930, 1003, 1429, 1733, 2109, 2159, 2709, 2862, 2868, 3073, 3240, 3495, 3834, 4187], 'receptor': [931, 1005, 1240, 1431, 2164, 2264, 2321, 2631, 2773, 2943, 3006, 3074, 3496, 4188, 4190], 'its': [933, 1248, 1418, 1895, 2063, 2552, 3390], 'ligand': [934], 'apolipoprotein': [935, 1242, 2624, 3961], 'B,': [936, 1169, 1243, 1813, 1819, 1825, 2736, 2930, 3526, 3602, 3703, 3721, 3723, 4020], 'been': [938, 981, 988], 'two': [940, 2492], 'classically': [942], 'implicated': [943, 1973], 'autosomal': [945, 1193, 1244, 1335, 2967, 4063], 'dominant': [946, 1194, 1245, 1336, 2968, 3734, 3970, 4064], 'hypercholesterolemia': [947, 997, 1047, 1246, 2030, 2256, 2499, 2595, 3333, 3470, 4005, 4065], '(ADH).': [948], 'Our': [949], 'discovery': [950], '2003': [952], 'first': [955], 'mutations': [956, 995, 1056, 1326, 1467, 1485, 1596, 1633, 1773, 2259, 3473, 3573, 4222], 'causing': [966, 996, 4003], 'ADH': [967], 'shed': [968], 'light': [969], 'on': [970, 1031, 1425, 1601, 2161, 3392, 3579, 3960], 'an': [971], 'unknown': [972], 'actor': [973, 1217], 'that': [977, 1051, 1068, 1545], 'since': [978], 'then': [979], 'has': [980], 'extensively': [982], 'investigated.': [983], 'Several': [984], 'PCSK9': [985, 1191, 1329, 1456, 1488, 1599, 1640, 1660, 1716, 1830, 1893, 1923, 2024, 2060, 2101, 2375, 2407, 2445, 2456, 2494, 2525, 2649, 2701, 2807, 2898, 2945, 2961, 3003, 3093, 3135, 3175, 3213, 3235, 3269, 3278, 3344, 3388, 3577, 3779, 3926, 3959, 4002, 4138, 4224], 'variants': [986, 1011, 3267, 3276, 3924], 'identified,': [989], 'some': [990], 'them': [992], 'are': [993, 1009, 1052, 1490, 2910, 3177], 'gain-of-function': [994], 'reduction': [1000, 1015], '(LDL)': [1004, 1430, 2160], 'levels;': [1006], 'while': [1007], 'others': [1008], 'loss-of-function': [1010, 3212, 4221], 'associated': [1012, 1054, 1491, 2027, 2496, 2652, 3784, 4140], 'LDL-cholesterol': [1017, 4144], '(LDL-C)': [1018], 'levels': [1019, 1077, 1685, 1735, 2292, 2706, 3136, 3176, 3286, 3789], 'decreased': [1022, 2911], 'risk': [1023, 1126, 2656, 3792], 'CHD.': [1025], 'In': [1026], 'review,': [1028], 'we': [1029, 1060], 'focus': [1030], 'reported': [1032], 'variants,': [1033], 'their': [1035], 'biological,': [1036], 'clinical,': [1037], 'functional': [1039, 1463], 'relevance.': [1040], 'We': [1041], 'also': [1042], 'highlight': [1043], 'spectrum': [1045, 2699], 'or': [1048, 4271], 'hypobetalipoproteinemia': [1049], 'phenotypes': [1050], 'already': [1053], 'PCSK9.': [1058, 1251, 1775, 2776, 3475], 'Finally,': [1059], 'present': [1061, 2527], 'future': [1062], 'prospects': [1063], 'concerning': [1064], 'therapeutic': [1066], 'target': [1067, 3041], 'might': [1069, 3279], 'constitute': [1070], 'new': [1072, 1216, 2300], 'approach': [1073, 2215], 'reduce': [1075, 3237], 'CHD,': [1079], 'enhance': [1081], 'effectiveness': [1083], 'other': [1085], 'lipid-lowering': [1086], 'drugs.': [1087], 'Hum': [1088, 1338, 1607, 2713, 3697, 3760, 3934, 3972, 4010, 4071, 4149, 4233], 'Mutat': [1089, 1339, 4150], '0,': [1090], '1–11,': [1091], '2008.': [1092, 1629, 1680, 1922, 2056, 2373, 2647, 2739, 2768, 2896, 2937, 3173, 3265, 3821], '©': [1093], '2008': [1094], 'Wiley-Liss,': [1095], 'Inc.': [1096], 'REFERENCES': [1097], 'Abboud': [1098], 'S,': [1099, 1105, 1109, 1151, 1297, 1376, 1442, 1515, 1878, 1987, 2047, 2124, 2240, 2242, 2719, 2887, 2926, 2928, 3366, 3400, 3516, 3522, 3566, 3590, 3627, 3868, 3876, 3915, 3981, 3989, 4044], 'Karhunen': [1100], 'PJ,': [1101, 2480], 'Lütjohann': [1102], 'D,': [1103, 1143, 1155, 1295, 1378, 1394, 1444, 1852, 1884, 2015, 2043, 2078, 2080, 2130, 2881, 2998, 3319, 3552, 3560, 3600, 3713, 3719, 3948, 4087], 'Goebeler': [1104], 'Luoto': [1106], 'T,': [1107, 1111, 1586, 1622, 1624, 1651, 1909, 2071, 2435, 2833, 3156, 3262, 3461, 3665, 3909], 'Friedrichs': [1108], 'Lehtimaki': [1110], 'Pandolfo': [1112], 'M,': [1113, 1137, 1139, 1147, 1161, 1181, 1202, 1229, 1299, 1301, 1303, 1307, 1317, 1392, 1396, 1398, 1410, 1509, 1917, 1919, 2090, 2126, 2232, 2238, 2734, 2837, 2841, 2932, 3120, 3128, 3130, 3160, 3168, 3193, 3449, 3455, 3457, 3562, 3705, 3711, 3717, 3725, 3766, 3814, 4016, 4028, 4030, 4032, 4046, 4050, 4052, 4089, 4128, 4163], 'Laaksonen': [1114], 'R.': [1115], '2007.': [1116, 1236, 1274, 1518, 1887, 2093, 2152, 2178, 2344, 2401, 2438, 2487, 2520, 2547, 3001, 3133, 3200, 3227, 3379, 3529, 3777, 4170], 'Proprotein': [1117], 'subtilisin/kexin': [1119, 2184, 2350, 2749, 3501, 3825, 4175], 'type': [1120, 1280, 1691, 2185, 2351, 2750, 2855, 3306, 3502, 3735, 3826, 4176], 'factor': [1127], 'large-vessel': [1129], 'atherosclerosis': [1130], 'stroke.': [1131], 'PLoS': [1132], 'ONE': [1133], '2:': [1134], 'e1043.': [1135], 'Rabes': [1140, 1203, 1230, 1322, 3708, 4017], 'JP,': [1141, 1204, 1231, 1311, 3709, 4018], 'Allard': [1142, 1294, 1393], 'Ouguerram': [1144, 2727, 3446], 'K,': [1145, 2230, 2568, 2728, 3404, 3447, 3907, 3985], 'Cruaud': [1148], 'C,': [1149, 1183, 1206, 1233, 1315, 1319, 1406, 2722, 2724, 2839, 2921, 2924, 2978, 3124, 3321, 3328, 3459, 3548, 3707, 3727, 3729, 3768, 4054], 'Benjannet': [1150, 1375, 1441, 1986, 3365, 3867], 'Wickham': [1152, 1383, 1990, 3869], 'L,': [1153, 1159, 1384, 1408, 1480, 1957, 1991, 2049, 2082, 3402, 3545, 3870, 4208], 'Derre': [1156], 'A,': [1157, 1179, 1313, 1400, 1412, 1751, 1823, 1911, 1949, 1985, 1989, 2134, 2140, 2149, 2337, 2366, 2686, 2688, 2885, 3116, 3118, 3158, 3162, 3258, 3364, 3376, 3424, 3554, 3558, 3592, 3812, 3878, 3880, 4022, 4048], 'Villeger': [1158], 'Farnier': [1160, 3724, 4049], 'Beucler': [1162], 'I,': [1163, 3317, 3944], 'Bruckert': [1164], 'E,': [1165, 1784, 2076, 3032, 3594], 'Chambaz': [1166], 'J,': [1167, 1177, 1269, 1382, 1390, 1446, 1582, 1614, 1649, 1749, 1913, 1953, 2394, 2431, 2883, 2976, 3114, 3154, 3195, 3296, 3368, 3596, 3872], 'Chanu': [1168, 3720], 'Lecerf': [1170], 'JM,': [1171, 2175, 3414, 4097], 'Luc': [1172, 1304], 'G,': [1173, 1261, 1305, 1677, 1815, 1947, 2234, 2829, 2875, 2992, 2996], 'Moulin': [1174], 'P,': [1175, 1321, 1811, 2122, 2732, 2934, 3453, 3564, 3715, 4126], 'Weissenbach': [1176], 'Prat': [1178, 1411, 1958, 3375, 3591, 3847, 3879], 'Krempf': [1180, 1306, 1826, 2733, 2840, 2931, 3462, 3716, 4029], 'Seidah': [1184, 1413, 1449, 1914, 1954, 1992, 3125, 3196, 3377, 3605, 3845, 3865], 'NG,': [1185, 1915, 1955, 3126, 3197, 3846, 3866], 'C.': [1187, 3731, 4056], '2003.': [1188, 3035, 3427, 3883], 'cause': [1192, 1331, 3966], 'hypercholesterolemia.': [1195, 1337, 1900, 1976, 2676, 2969, 3584], 'Nat': [1196, 1776, 1901], 'Genet': [1197, 1609, 1777, 2039, 2714, 2971, 3761, 3935, 3974, 4011, 4072, 4234], '34:': [1198], '154–': [1199], '156.': [1200], 'M.': [1208, 1235, 1827, 3172, 3199, 3463, 3882], '2006.': [1209, 1567, 1593, 1790, 1828, 2018, 2697, 2805, 2844, 3569, 3607, 4133, 4217], 'PCSK9,': [1210, 1794, 1963, 3202], 'from': [1211, 1770, 2502], 'protein:': [1214], 'involved': [1218], 'homeostasis.': [1221], 'Med': [1222, 1644, 1806, 2038, 2223, 2325, 2664, 2679, 3216], 'Sci': [1223, 1558, 2423, 2559, 2636, 2780, 3080, 3108, 3659, 3798, 3901], '(Paris)': [1224, 1254], '22:': [1225], '916–': [1226], '918.': [1227], 'After': [1237], 'LDL': [1239, 1433, 1605, 1762, 2163, 2191, 2263, 2355, 2379, 2442, 2555, 2772, 2812, 2902, 3005, 3284], 'reveals': [1247, 2411], 'third': [1249, 2591, 3753, 4059], 'protagonist:': [1250], 'Ann': [1252], 'Endocrinol': [1253], '68:': [1255], '138–': [1256], '146.': [1257], 'Alborn': [1258, 1672, 3815], 'WE,': [1259, 1673, 3816], 'Cao': [1260, 1676, 3819], 'Careskey': [1262, 1668], 'HE,': [1263, 1669], 'Qian': [1264, 3809], 'YW,': [1265, 3810], 'Subramaniam': [1266, 2336], 'DR,': [1267, 2478, 2889], 'Davies': [1268], 'Conner': [1270], 'EM,': [1271, 3030], 'Konrad': [1272, 1678, 3817], 'RJ.': [1273, 1679], 'Serum': [1275], 'correlated': [1283], 'directly': [1284], 'serum': [1286, 1684, 2354], 'ldl': [1287], 'cholesterol.': [1288, 1434, 2110, 2710], 'Clin': [1289, 2306, 2823, 2915, 2970, 3797], 'Chem': [1290, 1437, 1473, 1847, 2010, 2168, 2754, 2916, 3247, 3509, 4197], '53:': [1291], '1814–': [1292], '1819.': [1293], 'Amsellem': [1296], 'Trillard': [1300, 1395], 'Reznik': [1308], 'Y,': [1309, 1708, 2730, 3252, 3256, 3410, 3451, 3635, 3911, 3917, 4204], 'Girardet': [1310], 'Fredenrich': [1312], 'Benlian': [1320], 'JP.': [1323], '2005.': [1324, 1713, 1760, 3331, 3644, 3953], 'Novel': [1325, 3036], 'variable': [1332], 'phenotype': [1333, 3581], '26:': [1340, 1505], '497.': [1341], 'Austin': [1342], 'MA,': [1343, 1588, 1620, 1653], 'King': [1344], 'MC,': [1345, 1388, 1858, 2368, 2763, 2792, 3222], 'Bawol': [1346], 'RD,': [1347], 'Hulley': [1348], 'SB,': [1349, 3874], 'Friedman': [1350], 'GD.': [1351], '1987.': [1352, 2621], 'Risk': [1353], 'factors': [1354], 'adult': [1360], 'female': [1361], 'twins.': [1362], 'Genetic': [1363, 2288, 2584, 3266, 3923], 'heritability': [1364], 'shared': [1366], 'environmental': [1367], 'influences.': [1368], 'Am': [1369, 1742, 2677, 2711, 4069, 4119, 4231], 'J': [1370, 1435, 1471, 1642, 1694, 1741, 1805, 1845, 1942, 2008, 2166, 2222, 2305, 2326, 2359, 2383, 2663, 2678, 2712, 2752, 2822, 3013, 3052, 3245, 3309, 3507, 3621, 3759, 3933, 4070, 4120, 4195, 4232], 'Epidemiol': [1371, 2197], '125:': [1372], '308–': [1373], '318.': [1374], 'Rhainds': [1377, 1443], 'Essalmani': [1379], 'R,': [1380, 1755, 2086, 2143, 2236, 2248, 2474, 2790, 2986, 3254, 3556, 3631, 4034, 4159], 'Mayne': [1381, 1920, 3113, 3153, 3194], 'Jin': [1385], 'W,': [1386], 'Asselin': [1387], 'Hamelin': [1389, 1445, 1912, 3367], 'Tebon': [1399, 3362], 'Attie': [1401, 3373], 'AD,': [1402, 2466, 2470, 2515, 3325, 3374], 'Rader': [1403], 'DJ,': [1404], 'Brissette': [1407], 'Chretien': [1409, 3129, 3198, 3881], 'NG.': [1414, 1450, 1993, 3378, 3606], '2004.': [1415, 1960, 2957, 3062, 3464, 3489, 3922, 3998, 4100], 'NARC-1/PCSK9': [1416, 3613], 'natural': [1419, 1466], 'mutants:': [1420], 'zymogen': [1421], 'cleavage': [1422], 'effects': [1424], 'low': [1427, 1795, 2157, 2190, 2626, 3238, 3493, 4142, 4185], 'density': [1428, 2158, 2627, 3239, 3494, 4186], 'Biol': [1436, 1472, 1504, 1846, 1904, 1980, 2009, 2114, 2167, 2460, 2603, 2753, 3246, 3354, 3479, 3508, 3698, 4196], '279:': [1438, 3510], '48865–': [1439], '48875.': [1440], 'Nassoury': [1447, 3358], 'N,': [1448, 2246, 2472, 2877, 3122, 3359, 3913], '2006': [1451, 1483], '(PC)': [1455], 'inactivated': [1458], 'furin': [1460], 'and/or': [1461], 'PC5/6A:': [1462], 'consequences': [1464], 'post-translational': [1469], 'modifications.': [1470], '281:': [1474, 1848], '30561–': [1475], '30572.': [1476], 'Berge': [1477, 1589, 1625, 1656, 2432], 'KE,': [1478, 1590, 1626, 2433], 'Ose': [1479], 'Leren': [1481, 1591, 1627, 1654, 2436, 2955], 'TP.': [1482, 1592, 1628, 2437, 2956], 'Missense': [1484], 'hypocholesterolemia': [1493], 'possibly': [1495], 'increased': [1496], 'response': [1497], 'statin': [1499], 'therapy.': [1500], 'Arterioscler': [1501, 1977, 2111, 2600, 3351, 3476], 'Thromb': [1502, 1978, 2112, 2601, 3352, 3477], 'Vasc': [1503, 1979, 2113, 2602, 3353, 3478], '1094–': [1506], '1100.': [1507], 'Bourbon': [1508], 'Alves': [1510], 'AC,': [1511], 'Medeiros': [1512], 'AM,': [1513, 1706], 'Silva': [1514], 'Soutar': [1516, 3329, 3951], 'AK.': [1517, 2669, 3330, 3952], 'On': [1519], 'behalf': [1520], 'investigators': [1523], 'Portuguese': [1526], 'FH': [1527], 'study.': [1528], 'Familial': [1529, 2316, 2622, 3675], 'hypercholesterolaemia': [1530], 'Portugal.': [1532], 'Atherosclerosis': [1533, 1665, 2508, 2537, 3291, 3585], '196:': [1534, 2509, 3292], '633–': [1535], '642.': [1536], 'Brown': [1537, 1563, 2313], 'MS,': [1538, 1564], 'Goldstein': [1539, 1565, 2271, 2311], 'JL.': [1540, 1566, 3000, 3034, 3061, 3090], '1999.': [1541, 4057], 'A': [1542, 1714, 2094, 2410, 2648, 2698, 3999, 4058, 4183], 'proteolytic': [1543, 3010], 'pathway': [1544], 'controls': [1546], 'content': [1549, 4270], 'membranes,': [1551], 'cells,': [1552], 'blood.': [1554], 'Proc': [1555, 2420, 2633, 2777, 3077, 3105, 3656, 3898], 'Natl': [1556, 2421, 2634, 2778, 3078, 3106, 3657, 3899], 'Acad': [1557, 2422, 2635, 2779, 3079, 3107, 3658, 3900], 'USA': [1559, 2424, 2637, 2781, 3081, 3109, 3660, 3902], '96:': [1560], '11041–': [1561], '11048.': [1562], 'Biomedicine.': [1568], 'Lowering': [1569], 'LDL—not': [1570], 'only': [1571], 'how': [1572, 1575], 'low,': [1573], 'but': [1574, 2033, 3142], 'long?': [1576], 'Science': [1577, 2267], '311:': [1578], '1721–': [1579], '1723.': [1580], 'Cameron': [1581, 1613, 1648, 2430], 'Holla': [1583, 1615, 2428], 'OL,': [1584, 1616, 2429], 'Ranheim': [1585, 1621, 1650, 2434], 'Kulseth': [1587, 1619, 1652], 'Effect': [1594], 'cell': [1603], 'surface': [1604], 'receptors.': [1606], 'Mol': [1608, 1903, 3973], '15:': [1610, 3541], '1551–': [1611], '1558.': [1612], 'Laerdahl': [1617], 'JK,': [1618], 'Rognes': [1623], 'Characterization': [1630], 'novel': [1632, 1727, 2095, 3434], 'catalytic': [1636], 'domain': [1637], 'gene.': [1641], 'Intern': [1643], '263:': [1645], '420–': [1646], '431.': [1647], 'TP,': [1655, 3806], 'KE.': [1657], 'Berberine': [1658], 'decreases': [1659, 2808, 4189], 'expression': [1661, 1831, 2946, 3064], 'HepG2': [1663, 3243], 'cells.': [1664, 3244], '(in': [1666], 'press).': [1667], 'Davis': [1670], 'RA,': [1671, 3770], 'Troutt': [1674], 'JS,': [1675, 1868, 2891, 3418], 'Atorvastatin': [1681], 'increases': [1682, 4193], 'human': [1683, 2059, 2948], '(PCSK9).': [1693], 'Lipid': [1695, 2360, 2384, 3053, 3692], 'Res': [1696, 2361, 2385, 3054, 3148, 3840], '49:': [1697, 2386, 3936], '394–': [1698], '398.': [1699], 'Chen': [1700], 'SN,': [1701], 'Ballantyne': [1702], 'CM,': [1703], 'Gotto': [1704, 3301], 'Jr': [1705, 1786, 3302], 'Tan': [1707], 'Willerson': [1709], 'JT,': [1710], 'Marian': [1711], 'AJ.': [1712, 3018], 'common': [1715], 'haplotype,': [1717], 'encompassing': [1718], 'E670G': [1720, 2020], 'coding': [1721], 'single': [1722], 'nucleotide': [1723], 'polymorphism,': [1724], 'genetic': [1728, 3214, 3275], 'marker': [1729], 'plasma': [1731, 2705, 3283, 3538, 3646, 3787, 4143], 'severity': [1737], 'atherosclerosis.': [1740], 'Coll': [1743], 'Cardiol': [1744, 4121], '45:': [1745], '1611–': [1746], '1619.': [1747], 'Cohen': [1748, 1781, 2249, 2543, 2693, 4166, 4213], 'Pertsemlidis': [1750, 2685], 'Kotowski': [1752, 2683], 'IK,': [1753, 2684], 'Graham': [1754, 2330], 'Garcia': [1756, 2227], 'CK,': [1757, 2228, 3946], 'Hobbs': [1758, 1788, 2251, 2545, 2695, 4098, 4168, 4215], 'HH.': [1759, 1789, 2252, 2546, 2696, 4099, 4169, 4216], 'Low': [1761], 'individuals': [1765], 'African': [1767, 2535], 'descent': [1768], 'resulting': [1769], 'frequent': [1771], 'nonsense': [1772], '37:': [1778, 2680], '161–': [1779], '165.': [1780], 'JC,': [1782, 2128, 2250, 2544, 2694, 4024, 4040, 4167, 4214], 'Boerwinkle': [1783, 2176], 'Mosley': [1785], 'TH,': [1787], 'Sequence': [1791, 2179], 'variations': [1792], 'LDL,': [1796], 'protection': [1798], 'against': [1799], 'disease.': [1802, 2286, 2322], 'N': [1803, 2220, 2661], 'Engl': [1804, 2221, 2662], '354:': [1807], '1264–': [1808], '1272.': [1809], 'Costet': [1810, 2737, 2842, 2933, 3452], 'Cariou': [1812, 2735, 2935], 'Lambert': [1814, 2485, 2828, 2874], 'Lalanne': [1816], 'F,': [1817, 2244, 2468, 2476, 2879, 4026], 'Lardeux': [1818], 'Jarnoux': [1820, 2725, 2830], 'AL,': [1821, 2726, 2831], 'Grefhorst': [1822, 2365], 'Staels': [1824, 2929], 'Hepatic': [1829], 'regulated': [1833], 'nutritional': [1835], 'status': [1836], 'via': [1837], 'insulin': [1838], 'sterol': [1840], 'regulatory': [1841], 'element-binding': [1842], 'protein': [1843, 2452, 3497], '1c.': [1844], '6211–': [1849], '6218.': [1850], 'Cunningham': [1851], 'Danley': [1853], 'DE,': [1854, 2788, 3514, 3629], 'Geoghegan': [1855], 'KF,': [1856, 2988], 'Griffor': [1857], 'Hawkins': [1859], 'JL,': [1860, 2272, 2312, 2396], 'Subashi': [1861], 'TA,': [1862, 2370, 2761, 2786, 3224, 4157, 4206], 'Varghese': [1863], 'AH,': [1864, 3774], 'Ammirati': [1865], 'MJ,': [1866, 2331, 4036], 'Culp': [1867], 'Hoth': [1869], 'LR,': [1870], 'Mansour': [1871], 'MN,': [1872], 'McGrath': [1873], 'KM,': [1874, 2333, 3979], 'Seddon': [1875], 'AP,': [1876], 'Shenolikar': [1877], 'Stutzman-Engwall': [1879], 'KJ,': [1880], 'Warren': [1881], 'LC,': [1882], 'Xia': [1883], 'Qiu': [1885, 2046], 'X.': [1886], 'Structural': [1888], 'biophysical': [1890], 'studies': [1891], 'mutants': [1896, 2495], 'linked': [1897], 'familial': [1899, 1975, 2498, 2594, 2675, 3583], 'Struct': [1902], '14:': [1905, 3975], '413–': [1906], '419.': [1907], 'Dewpura': [1908, 3155], 'Raymond': [1910, 3115, 3157], 'Mbikay': [1916, 3127, 3167, 3192], 'Chrétien': [1918, 3171], 'J.': [1921, 2767], 'phosphorylated': [1925], 'Golgi': [1928], 'casein': [1929], 'kinase-like': [1930], 'kinase': [1931], 'ex': [1932], 'vivo': [1933], 'circulates': [1935], 'as': [1936, 3749, 3751, 3964], 'phosphoprotein': [1938], 'humans.': [1940, 3185], 'FEBS': [1941, 2950], '275:': [1943], '3480–': [1944], '3493.': [1945], 'Dubuc': [1946], 'Chamberland': [1948], 'Wassef': [1950], 'H,': [1951, 3260, 3919, 3987, 4038], 'Davignon': [1952], 'Bernier': [1956], 'A.': [1959, 2151, 3848], 'Statins': [1961], 'upregulate': [1962], 'neural': [1970, 3888], 'apoptosis-regulated': [1971, 3889], 'convertase-1': [1972], '24:': [1981, 3480], '1454–': [1982], '1459.': [1983], 'Elagoz': [1984], 'Mammarbassi': [1988], '2002.': [1994, 3849], 'Biosynthesis': [1995], 'cellular': [1997, 3381], 'trafficking': [1998, 3382], 'SKI-1/S1P:': [2002], 'ectodomain': [2003], 'shedding': [2004], 'requires': [2005], 'SKI-1': [2006], 'activity.': [2007, 2065, 3011], '277:': [2011], '11265–': [2012], '11275.': [2013], 'Evans': [2014], 'Beil': [2016], 'FU.': [2017], 'SNP': [2021], 'polygenic': [2029], 'men': [2032, 3141], 'not': [2034, 2447, 3143, 3231, 4266], 'women.': [2036, 3145], 'BMC': [2037, 2458], '7:': [2040], '66.': [2041], 'Fan': [2042], 'Yancey': [2044], 'PG,': [2045], 'Ding': [2048], 'Weeber': [2050], 'EJ,': [2051], 'Linton': [2052], 'MF,': [2053], 'Fazio': [2054], 'S.': [2055, 3568], 'Self-association': [2057], 'correlates': [2061], 'LDLR-degrading': [2064], 'Biochemistry': [2066], '47:': [2067], '1631–': [2068], '1639.': [2069], 'Fasano': [2070], 'Cefalu': [2072, 3549], 'AB,': [2073, 3550], 'Di': [2074], 'Leo': [2075], 'Noto': [2077, 3551], 'Pollaccia': [2079], 'Bocchi': [2081], 'Valenti': [2083], 'V,': [2084, 3370], 'Bonardi': [2085], 'Guardamagna': [2087], 'O,': [2088, 2835], 'Averna': [2089, 3561, 4127], 'Tarugi': [2091, 3563], 'P.': [2092, 2738, 2843], 'loss': [2096], 'function': [2098], 'mutation': [2099, 2523, 3341, 4000], 'white': [2104], 'subjects': [2105, 2965], 'low-plasma': [2107], '27:': [2115, 4151], '677–': [2116], '681.': [2117], 'Fisher': [2118, 3087], 'TS,': [2119, 3671], 'Lo': [2120, 3407], 'Surdo': [2121], 'Pandit': [2123], 'Mattu': [2125], 'Santoro': [2127], 'Wisniewski': [2129], 'Cummings': [2131], 'RT,': [2132], 'Calzetta': [2133], 'Cubbon': [2135], 'RM,': [2136, 2616, 4083], 'Fischer': [2137], 'PA,': [2138], 'Tarachandani': [2139], 'De': [2141], 'Francesco': [2142], 'Wright': [2144], 'SD,': [2145, 3323], 'Sparrow': [2146], 'CP,': [2147, 2335], 'Carfi': [2148], 'Sitlani': [2150], 'Effects': [2153], 'pH': [2155], 'PCSK9-dependent': [2162], 'regulation.': [2165], '282:': [2169, 3248, 4198], '20502–': [2170], '20512.': [2171], 'Folsom': [2172], 'AR,': [2173], 'Peacock': [2174], 'E.': [2177], 'variation': [2180, 4136], 'serine': [2187], 'protease': [2188], 'gene,': [2189], 'cholesterol,': [2192], 'cancer': [2194], 'incidence.': [2195], 'Cancer': [2196], 'Biomarkers': [2198], 'Prev': [2199], '16:': [2200], '2455–': [2201], '2458.': [2202], 'Fredrickson': [2203], 'DS,': [2204], 'Levy': [2205, 3297], 'RI,': [2206, 3298], 'Lees': [2207], 'RS.': [2208], '1967.': [2209], 'Fat': [2210], 'transport': [2211], 'lipoproteins-an': [2213], 'integrated': [2214], 'mechanisms': [2217, 2741], 'disorders.': [2219], '276:': [2224], '273–': [2225], '281.': [2226], 'Wilund': [2229], 'Arca': [2231], 'Zuliani': [2233], 'Fellin': [2235], 'Maioli': [2237], 'Calandra': [2239, 3565], 'Bertolini': [2241, 3567, 4043], 'Cossu': [2243], 'Grishin': [2245, 4209], 'Barnes': [2247], '2001.': [2253], 'Autosomal': [2254, 3733], 'recessive': [2255], 'caused': [2257], 'putative': [2262, 3037], 'adaptor': [2265], 'protein.': [2266], '292:': [2268], '1394–': [2269], '1398.': [2270], 'Schrott': [2273], 'HG,': [2274], 'Hazzard': [2275], 'WR,': [2276, 3808], 'Bierman': [2277], 'EL,': [2278], 'Motulsky': [2279], 'AG.': [2280], '1973.': [2281], 'Hyperlipidemia': [2282], 'II.': [2287], 'analysis': [2289, 3046], 'lipid': [2291, 3788], '176': [2294], 'families': [2295, 3337, 3682], 'delineation': [2297], 'inherited': [2301], 'disorder,': [2302], 'combined': [2303], 'hyperlipidemia.': [2304], 'Invest': [2307, 2824], '52:': [2308], '1544–': [2309], '1568.': [2310], 'MS.': [2314], '1978.': [2315], 'hypercholesterolemia:': [2317, 3737], 'pathogenesis': [2318], 'Johns': [2323], 'Hopkins': [2324, 2565, 3992], '143:': [2327], '8–': [2328], '16.': [2329], 'Lemonidis': [2332], 'Whipple': [2334], 'Monia': [2338], 'BP,': [2339, 3598], 'Crooke': [2340, 2342], 'ST,': [2341, 3524], 'RM.': [2343], 'Antisense': [2345], 'inhibition': [2346], 'reduces': [2353, 2377, 3828], 'hyperlipidemic': [2357], 'mice.': [2358, 2382, 2821, 3051], '48:': [2362], '763–': [2363], '767.': [2364], 'McNutt': [2367, 2762, 2791, 3221], 'Lagace': [2369, 2760, 2785, 3223, 4156, 4205], 'Horton': [2371, 2541, 2764, 2803, 3225, 3487, 3642, 4164, 4211], 'JD.': [2372, 2804, 3226, 3488, 3643], 'Plasma': [2374, 2897, 3134, 3174], 'preferentially': [2376], 'liver': [2378, 3048, 3893], 'receptors': [2380, 2443, 2813, 3241, 3835], '1303–': [2387], '1311.': [2388], 'Hampton': [2389, 2983], 'EN,': [2390, 2984], 'Knuth': [2391], 'MW,': [2392], 'Li': [2393, 2975], 'Harris': [2395, 2999], 'Lesley': [2397, 2993], 'SA,': [2398, 2994, 3166], 'Spraggon': [2399, 2991], 'G.': [2400, 2486, 3820, 4132], 'self-inhibited': [2403], 'structure': [2404, 3532], 'full-length': [2406], 'at': [2408], '1.9': [2409], 'structural': [2412], 'homology': [2413], 'resistin': [2415], 'within': [2416], 'C-terminal': [2418], 'domain.': [2419], '104:': [2425], '14604–': [2426], '14609.': [2427], 'Degradation': [2439], 'mediated': [2448], 'secreted': [2451, 3234], 'acted': [2453], 'upon': [2454], 'extracellularly.': [2457], 'Cell': [2459], '8:': [2461, 3396, 3762], '9.': [2462, 2751], 'Homer': [2463], 'VM,': [2464], 'Marais': [2465, 2514, 3324], 'Charlton': [2467, 2878], 'Laurie': [2469], 'Hurndell': [2471], 'Scott': [2473], 'Mangili': [2475], 'Sullivan': [2477, 2888], 'Barter': [2479, 2894], 'Rye': [2481, 2892], 'KA,': [2482, 2893, 3164], 'George': [2483], 'PM,': [2484, 3669], 'Identification': [2488], 'characterization': [2490, 3429, 4219], 'non-secreted': [2493], 'cohorts': [2501], 'New': [2503], 'Zealand': [2504], 'South': [2506], 'Africa.': [2507], '659–': [2510], '666.': [2511], 'Hooper': [2512], 'AJ,': [2513], 'Tanyanyiwa': [2516], 'DM,': [2517], 'Burnett': [2518], 'JR.': [2519], 'C679X': [2522], 'lowers': [2529], 'blood': [2530], 'Southern': [2534], 'population.': [2536, 3290, 4148], '193:': [2538], '445–': [2539], '448.': [2540], 'JD,': [2542, 2765, 3420, 4165, 4212], 'Molecular': [2548, 2769, 4218], 'biology': [2549], 'PCSK9:': [2551, 3534], 'role': [2553], 'metabolism.': [2556], 'Trends': [2557], 'Biochem': [2558, 3012, 3146, 3441, 3838, 3861], '32:': [2560], '71–': [2561], '77.': [2562], 'Hunt': [2563, 3994], 'SC,': [2564, 3995], 'PN,': [2566, 3993], 'Bulka': [2567], 'McDermott': [2569], 'MT,': [2570], 'Thorne': [2571], 'TL,': [2572, 2608], 'Wardell': [2573], 'BB,': [2574], 'Bowen': [2575], 'BR,': [2576], 'Ballinger': [2577], 'DG,': [2578], 'Skolnick': [2579, 3990], 'MH,': [2580, 3991], 'Samuels': [2581, 3982], 'ME.': [2582], '2000.': [2583, 3019, 3732], 'localization': [2585], 'chromosome': [2587], '1p32': [2588], 'locus': [2592, 4061], 'Utah': [2598, 4008], 'kindred.': [2599], '20:': [2604], '1089–': [2605], '1093.': [2606], 'Innerarity': [2607], 'Weisgraber': [2609], 'KH,': [2610], 'KS,': [2612], 'Mahley': [2613], 'RW,': [2614, 4079], 'Krauss': [2615], 'Vega': [2617, 2691], 'GL,': [2618, 2692], 'Grundy': [2619], 'SM.': [2620], 'defective': [2623], 'B-100:': [2625], 'lipoproteins': [2628, 3680], 'abnormal': [2630], 'binding.': [2632], '84:': [2638], '6919–': [2639], '6923.': [2640], 'Kathiresan': [2641], 'S;': [2642], 'Myocardial': [2643], 'Infarction': [2644], 'Genetics': [2645], 'Consortium.': [2646], 'missense': [2650], 'variant': [2651, 3782], 'reduced': [2655], 'early-onset': [2658], 'myocardial': [2659], 'infarction.': [2660], '358:': [2665], '2299–': [2666], '2300.': [2667], 'Khachadurian': [2668], '1964.': [2670], 'inheritance': [2672], 'essential': [2674], '402–': [2681], '407.': [2682], 'Luke': [2687], 'Cooper': [2689, 3771, 4090], 'RS,': [2690, 4091], 'alleles': [2702], 'contributes': [2703], '78:': [2715], '410–': [2716], '422.': [2717, 2974], 'Kourimate': [2718, 2925], 'Le': [2720, 2922], 'May': [2721, 2923], 'Langhi': [2723, 2920], 'Zaïr': [2729], 'Nguyen': [2731], 'Dual': [2740], 'fibrate-mediated': [2744], 'repression': [2745], '283:': [2755], '9666–': [2756], '9673.': [2757], 'Kwon': [2758], 'HJ,': [2759], 'Deisenhofer': [2766], 'basis': [2770], 'recognition': [2774], '105:': [2782], '1820–': [2783], '1825.': [2784], 'Curtis': [2787, 3628], 'Garuti': [2789, 3630, 4158], 'Park': [2793, 3483], 'SW,': [2794, 3484], 'Prather': [2795], 'HB,': [2796], 'Anderson': [2797, 3632], 'NN,': [2798, 3633], 'Ho': [2799, 3636], 'YK,': [2800, 3637], 'Hammer': [2801, 3638], 'RE,': [2802, 3028, 3639], 'Secreted': [2806, 3002, 3822], 'number': [2810], 'hepatocytes': [2815], 'livers': [2818], 'parabiotic': [2820], '116:': [2825], '2995–': [2826], '3005.': [2827], 'Pineau': [2832], 'Pape': [2834], 'Chetiveaux': [2836, 3448], 'Laboisse': [2838], 'Fasting': [2845], 'induces': [2846], 'hyperlipidemia': [2847], 'mice': [2849, 3068, 3653], 'overexpressing': [2850], '9:': [2856], 'lack': [2857], 'modulation': [2859], 'very-low-density': [2861], 'hepatic': [2863, 3830], 'output': [2864], 'receptor.': [2869], 'Endocrinology': [2870], '147:': [2871], '4985–': [2872], '4995.': [2873], 'Ancellin': [2876], 'Comas': [2880], 'Pilot': [2882], 'Keech': [2884], 'Patel': [2886, 3318, 3559], 'Cohn': [2890], 'PJ.': [2895], 'concentrations': [2899], 'correlate': [2900, 3137], 'total': [2904], 'diabetic': [2907], 'patients': [2908], 'fenofibrate': [2913], 'treatment.': [2914], '54:': [2917], '1038–': [2918], '1045.': [2919], 'Caron': [2927], 'B.': [2936, 3426], 'Activation': [2938], 'farnesoid': [2941], 'X': [2942], 'represses': [2944], 'hepatocytes.': [2949], 'Lett': [2951], '582:': [2952], '949–': [2953], '955.': [2954], 'Norwegian': [2964], '65:': [2972], '419–': [2973, 3700], 'Tumanut': [2977, 2985], 'Gavigan': [2979], 'JA,': [2980, 3772], 'Huang': [2981, 3409], 'WJ,': [2982], 'Suen': [2987], 'Trauger': [2989], 'JW,': [2990], 'Liau': [2995], 'Yowe': [2997], 'promotes': [3004], 'degradation': [3007, 3096], 'independently': [3008], '406:': [3014], '203–': [3015], '207.': [3016], 'Lusis': [3017], 'Atherosclerosis.': [3020], 'Nature': [3021], '407:': [3022], '233–': [3023], '241.': [3024], 'Maxwell': [3025, 3058, 3085], 'KN,': [3026, 3059, 3086], 'Soccio': [3027], 'Duncan': [3029], 'Sehayek': [3031], 'Breslow': [3033, 3060, 3089], 'SREBP': [3038], 'LXR': [3040], 'identified': [3043], 'microarray': [3045], 'cholesterol-fed': [3050], '44:': [3055], '2109–': [3056], '2119.': [3057], 'Adenoviral-mediated': [3063], 'Pcsk9': [3066], 'results': [3069], 'knockout': [3075], 'phenotype.': [3076], '101:': [3082], '7100–': [3083], '7105.': [3084], 'EA,': [3088], '2005.Overexpression': [3091], 'accelerates': [3094], 'LDLR': [3099, 3575, 3744], 'post-endoplasmic': [3102], 'reticulum': [3103], 'compartment.': [3104], '102:': [3110, 3661], '2069–': [3111], '2074.': [3112], 'Chaplin': [3117, 3161], 'Cousins': [3119, 3159], 'Kaefer': [3121], 'Gyamera-Acheampong': [3123], 'Ooi': [3131, 3169], 'TC.': [3132], 'Biophys': [3147, 3442, 3839], 'Commun': [3149, 3841], '361:': [3150], '451–': [3151], '456.': [3152], 'Lahey': [3163], 'Lahaye': [3165], 'TC,': [3170], 'significantly': [3178], 'modified': [3179], 'statins': [3181, 3651], 'fibrates': [3183], 'Lipids': [3186], 'Health': [3187], 'Dis': [3188], '11:': [3189], '7–': [3190], '22.': [3191], 'Of': [3201], 'homeostasis': [3204], 'parasitic': [3206], 'infections:': [3207], 'Possible': [3208], 'survival': [3209], 'benefits': [3210], 'polymorphisms.': [3215], 'Hypotheses': [3217], '69:': [3218], '1010–': [3219], '1017.': [3220], 'Catalytic': [3228], 'activity': [3229], 'required': [3232], '20799–': [3249], '20803.': [3250], 'Miyake': [3251], 'Kimura': [3253], 'Kokubo': [3255, 3910], 'Okayama': [3257], 'Tomoike': [3259], 'Yamamura': [3261], 'Miyata': [3263], 'T.': [3264], 'Japanese': [3272], 'population:': [3273], 'Rare': [3274], 'collectively': [3280], 'contribute': [3281], 'general': [3289], '29–': [3293], '36.': [3294], 'Morganroth': [3295], 'McMahon': [3299], 'AE,': [3300], 'AM.': [3303], '1974.': [3304], 'Pseudohomozygous': [3305], 'II': [3307], 'hyperlipoproteinemia.': [3308], 'Pediatr': [3310], '85:': [3311], '639–': [3312], '643.': [3313], 'Naoumova': [3314, 3949], 'RP,': [3315, 3950], 'Tosi': [3316, 3943], 'Neuwirth': [3320, 3945], 'Horswell': [3322], 'van': [3326], 'Heyningen': [3327], 'Severe': [3332], 'four': [3335], 'British': [3336], 'D374Y': [3340], 'gene:': [3345], 'long-term': [3346], 'follow-up': [3347], 'treatment': [3349], 'response.': [3350], '25:': [3355], '2654–': [3356], '2660.': [3357], 'Blasiole': [3360], 'DA,': [3361], 'Oler': [3363], 'Poupon': [3369], 'McPherson': [3371], 'PS,': [3372, 3422], 'secretory': [3385, 3854, 3885], 'dependence': [3391], 'LDLR.': [3394], 'Traffic': [3395], '718–': [3397], '732.': [3398], 'Naureckiene': [3399], 'Ma': [3401], 'Sreekumar': [3403], 'Purandare': [3405], 'U,': [3406], 'CF,': [3408], 'Chiang': [3411], 'LW,': [3412], 'Grenier': [3413], 'Ozenberger': [3415], 'BA,': [3416], 'Jacobsen': [3417], 'Kennedy': [3419], 'DiStefano': [3421], 'Wood': [3423], 'Bingham': [3425], 'Functional': [3428], 'Narc': [3431], '1,': [3432], 'proteinase': [3435, 3438], 'related': [3436, 3471], 'K.': [3439], 'Arch': [3440], '420:': [3443], '55–': [3444], '67.': [3445], 'Zair': [3450], 'Magot': [3460], 'Apolipoprotein': [3465], 'B100': [3466], 'autosomal-dominant': [3469, 4004], '1448–': [3481], '1453.': [3482], 'Moon': [3485, 3640], 'YA,': [3486, 3641], 'Post-transcriptional': [3490], 'regulation': [3491], '9a': [3503], 'mouse': [3505], 'liver.': [3506], '50630–': [3511], '50638.': [3512], 'Piper': [3513], 'Jackson': [3515], 'Liu': [3517], 'Q,': [3518], 'Romanow': [3519], 'WG,': [3520], 'Shetterly': [3521], 'Thibault': [3523], 'Shan': [3525], 'Walker': [3527], 'NP.': [3528], 'crystal': [3531], 'regulator': [3536], 'LDL-cholesterol.': [3539], 'Structure': [3540], '545–': [3542], '552.': [3543], 'Pisciotta': [3544], 'Priore': [3546], 'Oliva': [3547], 'Bellocchio': [3553], 'Fresa': [3555], 'Cantafora': [3557], 'Additive': [3570], 'effect': [3571, 3956], '186:': [3586], '433–': [3587], '440.': [3588], 'Poirier': [3589], 'Marcinkiewicz': [3593, 3871], 'Paquin': [3595], 'Chitramuthu': [3597], 'Baranowski': [3599], 'Cadieux': [3601], 'Bennett': [3603], 'HP,': [3604], 'Implication': [3608], 'development': [3616], 'nervous': [3619], 'system.': [3620], 'Neurochem': [3622], '98:': [3623], '838–': [3624], '850.': [3625], 'Rashid': [3626], 'Bashmakov': [3634], 'Decreased': [3645], 'hypersensitivity': [3649], 'lacking': [3654], 'Pcsk9.': [3655], '5374–': [3662], '5379.': [3663], 'Rice': [3664], 'Vogler': [3666], 'GP,': [3667], 'Laskarzewski': [3668], 'Perry': [3670], 'Rao': [3672], 'DC.': [3673], '1991.': [3674], 'aggregation': [3676], 'lipids': [3678], 'ascertained': [3683], 'through': [3684], 'random': [3685], 'nonrandom': [3687], 'probands': [3688], 'Minnesota': [3691], 'Research': [3693], 'Clinic': [3694], 'Family': [3695], 'Study.': [3696], '63:': [3699], '439.': [3701], 'Saint-Jore': [3702, 4019], 'Dachet': [3706], 'Blanchard': [3714], 'Mathe': [3718], 'Jacotot': [3722], 'Bonaiti-Pellie': [3726], 'IIa': [3736], 'evaluation': [3738], 'respective': [3741], 'contributions': [3742], 'APOB': [3746], 'defects': [3748], 'well': [3750], 'group': [3755], 'defects.': [3757], 'Eur': [3758], '621–': [3763], '630.': [3764], 'Scartezini': [3765], 'Hubbart': [3767], 'Whittall': [3769], 'Neil': [3773], 'Humphries': [3775], 'SE.': [3776], 'R46L': [3781], 'lower': [3786], 'cardiovascular': [3791, 4117], 'healthy': [3794], 'U.K.': [3795], 'men.': [3796], '(Lond)': [3799], '113:': [3800], '435–': [3801], '441.': [3802], 'Schmidt': [3803, 4037], 'RJ,': [3804, 3818], 'Beyer': [3805], 'Bensch': [3807], 'Lin': [3811, 4129], 'Kowala': [3813], 'both': [3829], 'extrahepatic': [3832], 'vivo.': [3837], '1370:': [3842], '634–': [3843], '640.': [3844], 'Precursor': [3850], 'convertases': [3851], 'pathway,': [3855], 'cytosol': [3856], 'extracellular': [3858], 'milieu.': [3859], 'Essays': [3860], '38:': [3862], '79–': [3863], '94.': [3864], 'Jasmin': [3873], 'Stifani': [3875], 'Basak': [3877], '1': [3891], '(NARC-1):': [3892], 'regeneration': [3894], 'neuronal': [3896], 'differentiation.': [3897], '100:': [3903], '928–': [3904], '933.': [3905], 'Shioji': [3906], 'Mannami': [3908], 'Inamoto': [3912], 'Takagi': [3914], 'Goto': [3916], 'Nonogi': [3918], 'Iwai': [3920], 'N.': [3921], 'affect': [3927], 'level': [3930], 'Japanese.': [3932], '109–': [3937], '114.': [3938], 'Sun': [3939], 'XM,': [3940], 'Eden': [3941], 'ER,': [3942], 'Wile': [3947], 'Evidence': [3954], 'mutant': [3958], 'B': [3962], 'secretion': [3963], 'unusually': [3968], 'severe': [3969], 'hypercholesterolaemia.': [3971], '1161–': [3976], '1169.': [3977], 'Timms': [3978], 'Wagner': [3980], 'ME,': [3983], 'Forbey': [3984], 'Goldfine': [3986], 'Jammulapati': [3988], 'Shattuck': [3996], 'DM.': [3997], 'pedigree.': [4009], '114:': [4012], '349–': [4013], '353.': [4014], 'Cenarro': [4021], 'Marinoni': [4023], 'Civeira': [4025], 'Coulon': [4031], 'Thiart': [4033], 'Kotze': [4035], 'Buzzi': [4039], 'Kostner': [4041], 'GM,': [4042], 'Pocovi': [4045], 'Rosa': [4047], 'Martinez': [4051], 'maps': [4066], '1p34.1-p32.': [4068], '64:': [4073], '1378–': [4074], '1387.': [4075], 'Victor': [4076], 'RG,': [4077], 'Haley': [4078], 'Willett': [4080], 'DL,': [4081], 'Peshock': [4082], 'Vaeth': [4084], 'PC,': [4085], 'Leonard': [4086], 'Basit': [4088], 'Iannacchione': [4092], 'VG,': [4093], 'Visscher': [4094], 'WA,': [4095], 'Staab': [4096], 'Dallas': [4102], 'Heart': [4103], 'Study:': [4104], 'population-based': [4106], 'probability': [4107], 'sample': [4108], 'multidisciplinary': [4111], 'study': [4112], 'ethnic': [4114], 'differences': [4115], 'health.': [4118], '93:': [4122], '1473–': [4123], '1480.': [4124], 'Yue': [4125], 'X,': [4130], 'Schonfeld': [4131], 'c.43_44insCTG': [4135], 'Caucasian': [4147], '460–': [4152], '466.': [4153], 'Zhang': [4154], 'DW,': [4155], 'Zhao': [4160, 4201], 'Z,': [4161, 4202], 'McDonald': [4162], 'Binding': [4171], 'epidermal': [4179], 'growth': [4180], 'factor-like': [4181], 'repeat': [4182], 'recycling': [4191], 'degradation.': [4194], '18602–': [4199], '18612.': [4200], 'Tuakli-Wosornu': [4203], 'Kinch': [4207], 'NV,': [4210], 'identification': [4226], 'compound': [4229], 'heterozygote.': [4230], '79:': [4235], '514–': [4236], '523.': [4237], 'Citing': [4238], 'Literature': [4239], 'Supporting': [4240, 4243, 4259], 'Information': [4241, 4244, 4260], 'Additional': [4242], 'may': [4245], 'be': [4246, 4288], 'found': [4247], 'online': [4250], 'article.': [4254, 4296], 'Filename': [4255], 'Description': [4256], 'humu_20882_sm_SupplMat.pdf107.1': [4257], 'KB': [4258], 'Please': [4261], 'note:': [4262], 'publisher': [4264], 'responsible': [4267], 'functionality': [4272], 'any': [4274], 'supporting': [4275], 'information': [4276], 'supplied': [4277], 'authors.': [4280], 'Any': [4281], 'queries': [4282], '(other': [4283], 'than': [4284], 'missing': [4285], 'content)': [4286], 'should': [4287], 'directed': [4289], 'corresponding': [4292], 'Volume30,': [4297], 'Issue4April': [4298], '2009Pages': [4299], 'ReferencesRelatedInformation': [4301]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028682402', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-09-24T12:15:55.001493', 'created_date': '2016-06-24'}