Title: Hypoxic protection against fast neutrons of different energies—A review
Abstract: Abstract The differences between the dependence of Oxygen Enhancement Ratio (OER) on fast neutron energy in P-388 murine leukaemia cells, and the lack of effect of neutron energy upon OER reported in human kidney-derived T-1 cells correlate well (perhaps fortuitously) with differences in responses of the same cells to irradiation with monoenergetic track-segments of beams of deuterons and alpha-particles whose ionization densities (LET) are known. However, irradiation of the P-388 tumour cells with collimated beams of fast neutrons at 10 cm depth in a tissue-equivalent phantom yields OER values lower than predicted by consideration of average LET and relatively independent of neutron energy. For irradiation from a planar array of neutron-emitting 25 2Cf sources in a tissue-equivalent holder simulating a brachytherapy implant, the OER is disappointingly high (2 · 0), although still significantly lower than for irradiation with 2 26Ra gamma rays in the same geometry.
Publication Year: 1971
Publication Date: 1971-05-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 33
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