Title: Immunochemical studies on dextrans—VI. Reactivity with antidextran of low molecular weight dextran and its iron-dextran complex (“imferon”)
Abstract: An iron-dextran preparation ('Imferon") is made by complexing of iron to a low molecular weight dextan (mol. wt. 5000). The resulting complex has a molecular weight of more than 150,000. Since some allergic reactions to infusions of iron-dextran are known, the free dextran and the iron-dextran complex were investigated for ability to precipitate with human antidextran sera and horse antipneumococcal sera known to crossreact with dextran. The results showed, the iron-dextran reacts as a complex to precipitate antidextran of α-(1 → 6) specificity, antipneumococcal antibody crossreacting with α-(1 → 6) linked dextran and concanavalin A, while the original dextran of low molecular weight does not; the iron is contained in the specific precipitate.
Publication Year: 1968
Publication Date: 1968-09-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 6
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