Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2028464107', 'doi': 'https://doi.org/10.1002/pros.20357', 'title': 'Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line', 'display_name': 'Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W2028464107', 'doi': 'https://doi.org/10.1002/pros.20357', 'mag': '2028464107', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16752376', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2802279'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pros.20357', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20357', 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20357', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061352936', 'display_name': 'Aubie Shaw', 'orcid': 'https://orcid.org/0000-0002-5298-801X'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aubie Shaw', 'raw_affiliation_strings': ['McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Wisconsin, USA.'], 'affiliations': [{'raw_affiliation_string': 'McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Wisconsin, USA.', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013472688', 'display_name': 'John Papadopoulos', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John Papadopoulos', 'raw_affiliation_strings': ['Urology'], 'affiliations': [{'raw_affiliation_string': 'Urology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019487486', 'display_name': 'Curtis D. Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Curtis Johnson', 'raw_affiliation_strings': ['University of Wisconsin –,'], 'affiliations': [{'raw_affiliation_string': 'University of Wisconsin –,', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041977242', 'display_name': 'Wade Bushman', 'orcid': 'https://orcid.org/0000-0003-3803-2449'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wade Bushman', 'raw_affiliation_strings': ['University of Wisconsin –,'], 'affiliations': [{'raw_affiliation_string': 'University of Wisconsin –,', 'institution_ids': ['https://openalex.org/I135310074']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4380, 'currency': 'USD', 'value_usd': 4380, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.116, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.824066, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '66', 'issue': '13', 'first_page': '1347', 'last_page': '1358'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11815', 'display_name': 'Urological Disorders and Treatments', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11815', 'display_name': 'Urological Disorders and Treatments', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12866', 'display_name': 'Urologic and reproductive health conditions', 'score': 0.9696, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mesenchyme', 'display_name': 'Mesenchyme', 'score': 0.8033197}], 'concepts': [{'id': 'https://openalex.org/C2776340970', 'wikidata': 'https://www.wikidata.org/wiki/Q32838', 'display_name': 'Mesenchyme', 'level': 3, 'score': 0.8033197}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.75979257}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.676479}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64832}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.44072735}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.44067964}, {'id': 'https://openalex.org/C198826908', 'wikidata': 'https://www.wikidata.org/wiki/Q1922379', 'display_name': 'Mesenchymal stem cell', 'level': 2, 'score': 0.43450817}, {'id': 'https://openalex.org/C147447768', 'wikidata': 'https://www.wikidata.org/wiki/Q411624', 'display_name': 'Vimentin', 'level': 3, 'score': 0.4107796}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35412633}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21432921}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.09263092}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008648', 'descriptor_name': 'Mesoderm', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D014566', 'descriptor_name': 'Urogenital System', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018920', 'descriptor_name': 'Coculture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009024', 'descriptor_name': 'Morphogenesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011467', 'descriptor_name': 'Prostate', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pros.20357', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20357', 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2802279', 'pdf_url': 'https://europepmc.org/articles/pmc2802279?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16752376', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/pros.20357', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20357', 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W171016471', 'https://openalex.org/W1967826862', 'https://openalex.org/W1971231305', 'https://openalex.org/W1974163686', 'https://openalex.org/W1974834539', 'https://openalex.org/W1982930815', 'https://openalex.org/W1997348862', 'https://openalex.org/W1998902718', 'https://openalex.org/W2004342059', 'https://openalex.org/W2005615385', 'https://openalex.org/W2014250521', 'https://openalex.org/W2015066175', 'https://openalex.org/W2018371450', 'https://openalex.org/W2040398116', 'https://openalex.org/W2040805114', 'https://openalex.org/W2049085719', 'https://openalex.org/W2055069711', 'https://openalex.org/W2058666572', 'https://openalex.org/W2066758604', 'https://openalex.org/W2068776422', 'https://openalex.org/W2069584787', 'https://openalex.org/W2077696436', 'https://openalex.org/W2078365768', 'https://openalex.org/W2083872253', 'https://openalex.org/W2094929131', 'https://openalex.org/W2099703259', 'https://openalex.org/W2104068965', 'https://openalex.org/W2117387587', 'https://openalex.org/W2149835742', 'https://openalex.org/W2170275585', 'https://openalex.org/W2415958131'], 'related_works': ['https://openalex.org/W3147393391', 'https://openalex.org/W2345113727', 'https://openalex.org/W2169713767', 'https://openalex.org/W2066692229', 'https://openalex.org/W2023445515', 'https://openalex.org/W1987492131', 'https://openalex.org/W1983177105', 'https://openalex.org/W1980760536', 'https://openalex.org/W1974491814', 'https://openalex.org/W1930366445'], 'abstract_inverted_index': {'The': [0, 531, 551, 700], 'ProstateVolume': [1], '66,': [2], 'Issue': [3], '13': [4, 870], 'p.': [5], '1347-1358': [6, 1532], 'Original': [7], 'Article': [8], 'Isolation': [9, 849], 'and': [10, 211, 215, 227, 234, 253, 273, 327, 336, 347, 359, 382, 400, 458, 533, 595, 615, 639, 677, 774, 798, 850, 1002, 1103, 1164, 1202, 1227, 1265, 1390, 1420, 1513], 'characterization': [11, 851], 'of': [12, 31, 45, 48, 62, 65, 83, 86, 90, 114, 128, 131, 145, 148, 166, 169, 173, 213, 223, 236, 247, 277, 286, 316, 409, 413, 418, 433, 440, 463, 536, 553, 568, 583, 591, 617, 637, 680, 727, 756, 770, 823, 852, 960, 970, 1004, 1032, 1037, 1109, 1134, 1223, 1270, 1294, 1359, 1383, 1418, 1474, 1503, 1510], 'an': [13, 267, 299, 451, 897, 1128], 'immortalized': [14, 300], 'mouse': [15, 307, 643], 'urogenital': [16, 309, 488, 555, 592, 963, 994, 1166, 1514], 'sinus': [17, 310, 489, 593, 964, 995, 1167, 1515], 'mesenchyme': [18, 490, 594, 1168], 'cell': [19, 289, 303, 491, 704, 806, 828, 858, 908, 941, 966, 997, 1014, 1391, 1508], 'line': [20, 304, 492, 705, 807, 829, 942, 967, 998, 1015], 'Aubie': [21, 23, 104, 106], 'Shaw,': [22, 105], 'Shaw': [24, 107, 1330], 'McArdle': [25, 108], 'Laboratory': [26, 109], 'for': [27, 35, 52, 69, 98, 110, 118, 135, 152, 181, 900, 946], 'Cancer': [28, 111, 779, 1020], 'Research,': [29, 112], 'University': [30, 47, 64, 85, 113, 130, 147, 168], 'Wisconsin,': [32, 49, 66, 87, 115, 132, 149, 170], 'Madison,': [33, 50, 67, 88, 95, 116, 133, 150, 171, 178], 'WisconsinSearch': [34, 51, 68, 117, 134, 151], 'more': [36, 53, 70, 99, 119, 136, 153, 182], 'papers': [37, 54, 71, 100, 120, 137, 154, 183], 'by': [38, 55, 72, 101, 121, 138, 155, 184, 283, 437, 482, 563], 'this': [39, 56, 73, 102, 122, 139, 156, 185, 248], 'authorJohn': [40, 123], 'Papadopoulos,': [41, 124], 'John': [42, 125], 'Papadopoulos': [43, 126], 'Department': [44, 61, 82, 127, 144, 165], 'Surgery,': [46, 63, 84, 91, 129, 146, 167, 174], 'authorCurtis': [57, 140], 'Johnson,': [58, 141], 'Curtis': [59, 142], 'Johnson': [60, 143], 'authorWade': [74, 157], 'Bushman,': [75, 158], 'Corresponding': [76, 159], 'Author': [77, 160], 'Wade': [78, 161], 'Bushman': [79, 162, 1065, 1191, 1340, 1466], '[email': [80, 163], 'protected]': [81, 164], 'WisconsinDepartment': [89, 172], '600': [92, 175], 'Highland': [93, 176], 'Ave.,': [94, 177], 'WI': [96, 179], '53792.Search': [97, 180], 'author': [103, 186], 'First': [187], 'published:': [188], '02': [189], 'June': [190], '2006': [191, 512], 'https://doi.org/10.1002/pros.20357Citations:': [192], '25AboutPDF': [193], 'ToolsRequest': [194], 'permissionExport': [195], 'citationAdd': [196], 'to': [197, 219, 242, 321, 325, 333, 447, 479, 497, 558, 713, 1267], 'favoritesTrack': [198], 'citation': [199], 'ShareShare': [200], 'Give': [201], 'accessShare': [202, 205], 'full': [203], 'text': [204], 'full-text': [206, 221, 245], 'accessPlease': [207], 'review': [208], 'our': [209], 'Terms': [210, 233], 'Conditions': [212, 235], 'Use': [214], 'check': [216], 'box': [217], 'below': [218, 241], 'share': [220, 243], 'version': [222, 246], 'article.I': [224], 'have': [225, 297], 'read': [226], 'accept': [228], 'the': [229, 239, 284, 306, 353, 397, 460, 464, 537, 564, 569, 621, 642, 672, 681, 768, 1132, 1135, 1206, 1268, 1292, 1384, 1472], 'Wiley': [230], 'Online': [231], 'Library': [232], 'UseShareable': [237], 'LinkUse': [238], 'link': [240], 'a': [244, 259, 367, 438, 475, 487, 732, 802, 824, 831, 853, 901, 961, 971, 1009, 1170], 'article': [249], 'with': [250, 338, 366, 393, 421, 470, 762], 'your': [251], 'friends': [252], 'colleagues.': [254], 'Learn': [255], 'more.Copy': [256], 'URL': [257], 'Share': [258], 'linkShare': [260], 'onEmailFacebookTwitterLinkedInRedditWechat': [261], 'Abstract': [262], 'BACKGROUND': [263], 'Stromal-epithelial': [264, 613, 1029], 'signaling': [265, 453, 1343, 1470], 'plays': [266, 1127], 'important': [268, 452, 503], 'role': [269, 1130], 'in': [270, 291, 329, 402, 427, 430, 455, 504, 587, 641, 671, 709, 711, 734, 767, 772, 801, 949, 1016, 1035, 1131, 1169, 1205, 1291, 1305, 1387, 1429, 1446], 'prostate': [271, 288, 301, 330, 339, 411, 456, 505, 676, 735, 759, 803, 826, 1074, 1235, 1271, 1345, 1447, 1482, 1505], 'development': [272, 670, 769], 'cancer': [274, 1012, 1448], 'progression.': [275, 1449], 'Study': [276], 'these': [278], 'interactions': [279, 500, 614, 948], 'will': [280], 'be': [281, 495], 'facilitated': [282], 'use': [285], 'suitable': [287], 'lines': [290], 'appropriate': [292], 'model': [293, 945], 'systems.': [294], 'METHODS': [295], 'We': [296, 312], 'isolated': [298, 414], 'mesenchymal': [302, 559, 760, 965, 996, 1070, 1104], 'from': [305, 597, 1423, 1506], 'E16': [308], '(UGS).': [311], 'characterized': [313], 'its': [314, 714], 'expression': [315, 362, 1072, 1473], 'stromal': [317, 715, 728, 827, 857, 939], 'differentiation': [318], 'markers,': [319], 'response': [320, 332, 462, 478, 552, 712], 'androgen': [322, 379, 383], 'stimulation,': [323, 335], 'ability': [324], 'induce': [326], 'participate': [328, 401], 'morphogenesis,': [331, 404], 'Shh': [334, 480], 'interaction': [337], 'epithelial': [340, 703, 764, 1013, 1102], 'cells.': [341, 442], 'RESULTS': [342], 'UGSM-2': [343, 376, 387, 419, 441, 443, 472, 485], 'cells': [344, 377, 388, 420, 424, 435, 444, 473, 761, 765], 'express': [345, 378], 'vimentin': [346], 'smooth': [348, 355, 729, 804, 906], 'muscle': [349, 356, 730, 805, 907], 'actin,': [350], 'but': [351, 405], 'not': [352, 407], 'mature': [354], 'markers': [357], 'myosin': [358], 'desmin.': [360], 'This': [361], 'profile': [363], 'is': [364, 486, 561, 896], 'consistent': [365], 'myofibroblast': [368, 940], 'phenotype.': [369], 'Unlike': [370], 'other': [371], 'fibroblasts': [372, 1421], 'such': [373], 'as': [374, 731], '3T3,': [375], 'receptor': [380], 'mRNA': [381], 'stimulation': [384], 'increases': [385], 'proliferation.': [386], 'are': [389, 406, 445, 502], 'viable': [390], 'when': [391], 'grafted': [392], 'embryonic': [394], 'UGS': [395, 415, 466], 'under': [396], 'renal': [398], 'capsule': [399], 'glandular': [403], 'capable': [408], 'inducing': [410], 'morphogenesis': [412, 1204], 'epithelium.': [416, 1113], 'Co-culture': [417], 'human': [422, 825, 855, 937, 1010, 1161, 1233, 1295], 'BPH-1': [423, 434], 'or': [425, 599], 'co-grafting': [426], 'vivo': [428, 710, 1501], 'results': [429, 766], 'organized': [431], 'clusters': [432], 'surrounded': [436], 'mantle': [439], 'responsive': [446], 'Sonic': [448, 1067, 1468], 'hedgehog': [449, 1068, 1469], '(Shh),': [450], 'factor': [454, 733, 1194, 1477], 'development,': [457], 'mimic': [459], 'transcriptional': [461, 477], 'intact': [465], 'mesenchyme.': [467, 1516], 'In': [468, 861, 976, 1500], 'co-cultures': [469], 'BPH-1,': [471], 'exhibit': [474], 'robust': [476], 'secreted': [481], 'BPH-1.': [483], 'CONCLUSIONS': [484], 'that': [493, 501, 1101], 'can': [494, 707], 'used': [496], 'study': [498, 1269], 'stromal-epithelial': [499, 947], 'biology.': [506], 'Prostate': [507, 717], '66:': [508], '1347–1358,': [509], '2006.': [510], '©': [511], 'Wiley-Liss,': [513], 'Inc.': [514], 'REFERENCES': [515], '1': [516], 'Cunha': [517, 549, 580, 607, 632, 661, 667, 698, 1025, 1098, 1124, 1156, 1243], 'GR,': [518, 608, 633, 1026], 'Donjacour': [519, 578, 609, 630, 1120, 1245], 'AA,': [520, 579, 610, 631, 1121, 1123], 'Cooke': [521], 'PS,': [522, 923], 'Mee': [523], 'S,': [524, 880, 1216], 'Bigsby': [525], 'RM,': [526], 'Higgins': [527], 'SJ,': [528, 988], 'Sugimura': [529, 611, 634], 'Y.': [530, 612, 635], 'endocrinology': [532], 'developmental': [534], 'biology': [535], 'prostate.': [538, 622, 644, 1137, 1208], 'Endocr': [539], 'Rev': [540], '1987;': [541, 649], '8(3):': [542], '338–362.': [543], '2': [544], 'Boutin': [545], 'EL,': [546], 'Battle': [547], 'E,': [548, 884, 888, 1218, 1285], 'GR.': [550, 581, 668, 699, 1125, 1157], 'female': [554], 'tract': [556], 'epithelia': [557, 1512], 'inductors': [560], 'restricted': [562], 'germ': [565], 'layer': [566], 'origin': [567], 'epithelium:': [570], 'Prostatic': [571], 'inductions.': [572], 'Differentiation': [573, 737, 1174], '1991;': [574], '48(2):': [575], '99–105.': [576], '3': [577], 'Assessment': [582], 'prostatic': [584, 702, 856, 905, 938, 950, 1033, 1112, 1162], 'protein': [585, 1197], 'secretion': [586], 'tissue': [588, 1171], 'recombinants': [589], 'made': [590], 'urothelium': [596, 1036], 'normal': [598], 'androgen-insensitive': [600], 'mice.': [601, 1041], 'Endocrinology': [602, 809, 1349], '1993;': [603], '132(6):': [604], '2342–2350.': [605], '4': [606, 1198], 'heterogeneity': [616], 'proliferative': [618], 'activity': [619], 'within': [620], 'Biochem': [623, 1044], 'Cell': [624, 863, 912, 978, 1393], 'Biol': [625, 647, 865, 980, 1079, 1115, 1139, 1210], '1986;': [626], '64(6):': [627], '608–614.': [628], '5': [629], 'Heterogeneity': [636], 'structure': [638], 'function': [640], 'Prog': [645], 'Clin': [646], 'Res': [648], '239:': [650], '583–600.': [651], '6': [652], 'Hayward': [653, 690, 1144], 'SW,': [654, 691, 1145], 'Baskin': [655], 'LS,': [656], 'Haughney': [657, 692, 1146], 'PC,': [658, 693, 1147], 'Foster': [659], 'BA,': [660], 'AR,': [662], 'Dahiya': [663, 1154], 'R,': [664, 1155, 1283, 1327, 1337], 'Prins': [665], 'GS,': [666], 'Stromal': [669], 'ventral': [673], 'prostate,': [674], 'anterior': [675], 'seminal': [678], 'vesicle': [679], 'rat.': [682], 'Acta': [683], 'Anat': [684], '(Basel)': [685], '1996;': [686, 810, 1394], '155(2):': [687], '94–103.': [688], '7': [689], 'Lopes': [694], 'ES,': [695], 'Danielpour': [696], 'D,': [697, 882, 925, 1062, 1095, 1379], 'rat': [701, 758, 993, 1165], 'NRP-152': [706], 'differentiate': [708], 'environment.': [716], '1999;': [718, 953, 1239], '39(3):': [719], '205–212.': [720], '8': [721], 'Wong': [722], 'YC,': [723], 'Tam': [724], 'NN.': [725], 'Dedifferentiation': [726], 'carcinogenesis.': [736], '2002;': [738, 1080], '70(9–10):': [739], '633–645.': [740], '9': [741], 'Chung': [742, 989, 1027], 'LW,': [743], 'Chang': [744, 845], 'SM,': [745], 'Bell': [746], 'C,': [747, 1377], 'Zhau': [748, 985], 'HE,': [749, 986], 'Ro': [750], 'JY,': [751], 'von': [752], 'Eschenbach': [753], 'AC.': [754], 'Co-inoculation': [755], 'tumorigenic': [757], 'non-tumorigenic': [763], 'carcinosarcoma': [771], 'syngeneic': [773], 'athymic': [775], 'animals.': [776], 'Int': [777, 1018, 1431], 'J': [778, 835, 911, 1019, 1042, 1237, 1260, 1432, 1450], '1989;': [780], '43(6):': [781], '1179–1187.': [782], '10': [783], 'Gerdes': [784], 'MJ,': [785], 'Dang': [786], 'TD,': [787], 'Lu': [788], 'B,': [789], 'Larsen': [790], 'M,': [791, 1371], 'McBride': [792], 'L,': [793, 1317, 1375, 1491], 'Rowley': [794, 957, 1442], 'DR.': [795, 958, 1443], 'Androgen-regulated': [796], 'proliferation': [797], 'gene': [799], 'transcription': [800], '(PS-1).': [808], '137(3):': [811], '864–872.': [812], '11': [813], 'Price': [814], 'DT,': [815], 'Rudner': [816], 'X,': [817], 'Michelotti': [818], 'GA,': [819], 'Schwinn': [820], 'DA.': [821], 'Immortalization': [822], 'using': [830], 'recombinant': [832], 'retroviral': [833], 'approach.': [834], 'Urol': [836, 1238, 1451], '2000;': [837, 914], '164(6):': [838], '2145–2150.': [839], '12': [840], 'Roberson': [841], 'KM,': [842, 1151], 'Edwards': [843], 'DW,': [844], 'GC,': [846], 'Robertson': [847, 1398], 'CN.': [848], 'novel': [854, 902], 'culture:': [859], 'DuK50.': [860], 'Vitro': [862, 977], 'Dev': [864, 979, 1078, 1114, 1138, 1209, 1365, 1484], 'Anim': [866], '1995;': [867, 1366], '31(11):': [868], '840–845.': [869], 'Salm': [871], 'SN,': [872], 'Koikawa': [873], 'Y,': [874, 1495], 'Ogilvie': [875], 'V,': [876], 'Tsujimura': [877], 'A,': [878, 1331, 1335], 'Coetzee': [879], 'Moscatelli': [881], 'Moore': [883], 'Lepor': [885], 'H,': [886, 1087, 1373, 1493], 'Shapiro': [887, 1217], 'Sun': [889], 'TT,': [890], 'Wilson': [891], 'EL.': [892], 'Transforming': [893], 'growth': [894, 973, 1001, 1006, 1133, 1225, 1229, 1476], 'factor-beta': [895, 1230], 'autocrine': [898], 'mitogen': [899], 'androgen-responsive': [903], 'murine': [904, 1504], 'line,': [909], 'PSMC1.': [910], 'Physiol': [913], '185(3):': [915], '416–424.': [916], '14': [917], 'Webber': [918], 'MM,': [919], 'Trakul': [920], 'N,': [921], 'Thraves': [922], 'Bello-DeOcampo': [924], 'Chu': [926], 'WW,': [927], 'Storto': [928], 'PD,': [929], 'Huard': [930], 'TK,': [931], 'Rhim': [932], 'JS,': [933], 'Williams': [934, 1414], 'DE.': [935], 'A': [936, 944, 991, 1288], 'WPMY-1:': [943], 'neoplasia.': [951], 'Carcinogenesis': [952], '20(7):': [954], '1185–1192.': [955], '15': [956], 'Characterization': [959], 'fetal': [962, 992, 1136, 1234, 1481], 'U4F:': [968], 'Secretion': [969], 'negative': [972], 'regulatory': [974], 'activity.': [975], '1992;': [981], '28A(1):': [982], '29–38.': [983], '16': [984], 'Hong': [987], 'LW.': [990, 1028], '(rUGM):': [999], 'Accelerated': [1000], 'conferral': [1003], 'androgen-induced': [1005], 'responsiveness': [1007], 'upon': [1008], 'bladder': [1011], 'vivo.': [1017], '1994;': [1021], '56(5):': [1022], '706–714.': [1023], '17': [1024], 'interactions–I.': [1030], 'Induction': [1031], 'phenotype': [1034], 'testicular': [1038], 'feminized': [1039], '(Tfm/y)': [1040], 'Steroid': [1043], '1981;': [1045], '14(12):': [1046], '1317–1324.': [1047], '18': [1048], 'Lamm': [1049, 1179, 1332], 'ML,': [1050, 1180, 1333], 'Catbagan': [1051, 1322], 'WS,': [1052], 'Laciak': [1053, 1326], 'RJ,': [1054, 1457], 'Barnett': [1055, 1183, 1460], 'DH,': [1056, 1184, 1461], 'Hebner': [1057, 1189], 'CM,': [1058, 1190], 'Gaffield': [1059], 'W,': [1060, 1323], 'Walterhouse': [1061], 'Iannaccone': [1063], 'P,': [1064, 1089, 1497], 'W.': [1066, 1192, 1287, 1341, 1467], 'activates': [1069], 'Gli1': [1071], 'during': [1073, 1231, 1480], 'ductal': [1075, 1200], 'bud': [1076], 'formation.': [1077], '249(2):': [1081], '349–366.': [1082], '19': [1083], 'Risbridger': [1084], 'G,': [1085, 1244], 'Wang': [1086, 1092], 'Young': [1088], 'Kurita': [1090], 'T,': [1091], 'YZ,': [1093], 'Lubahn': [1094], 'Gustafsson': [1096], 'JA,': [1097, 1405, 1439], 'G.': [1099], 'Evidence': [1100], 'estrogen': [1105, 1110], 'receptor-alpha': [1106], 'mediates': [1107], 'effects': [1108], 'on': [1111], '2001;': [1116, 1211, 1452], '229(2):': [1117], '432–442.': [1118], '20': [1119], 'Thomson': [1122], 'FGF-10': [1126], 'essential': [1129], '2003;': [1140, 1522], '261(1):': [1141], '39–54.': [1142], '21': [1143], 'Rosen': [1148], 'MA,': [1149], 'Greulich': [1150], 'Weier': [1152], 'HU,': [1153], 'Interactions': [1158], 'between': [1159], 'adult': [1160], 'epithelium': [1163], 'recombination': [1172], 'model.': [1173], '1998;': [1175], '63(3):': [1176], '131–140.': [1177], '22': [1178], 'Podlasek': [1181], 'CA,': [1182], 'Lee': [1185, 1372], 'J,': [1186, 1329, 1401], 'Clemens': [1187], 'JQ,': [1188], 'Mesenchymal': [1193], 'bone': [1195], 'morphogenetic': [1196], 'restricts': [1199], 'budding': [1201], 'branching': [1203], 'developing': [1207], '232(2):': [1212], '301–314.': [1213], '23': [1214], 'Raghow': [1215], 'Steiner': [1219], 'MS.': [1220], 'Immunohistochemical': [1221], 'localization': [1222], 'transforming': [1224, 1228], 'factor-alpha': [1226], 'early': [1232], 'development.': [1236, 1483], '162(2):': [1240], '509–513.': [1241], '24': [1242], 'A.': [1246], 'Mesenchymal-epithelial': [1247], 'interactions:': [1248], 'Technical': [1249], 'considerations.': [1250], 'In:': [1251, 1297], 'D': [1252], 'Coffey,': [1253], 'N': [1254], 'Bruchovsky,': [1255], 'W': [1256], 'Gardner,': [1257], 'M': [1258], 'Resnick,': [1259], 'Karr,': [1261], 'editors.': [1262, 1302], 'Current': [1263], 'concepts': [1264], 'approaches': [1266], 'cancer.': [1272], 'New': [1273], 'York:': [1274], 'AR': [1275], 'Liss,': [1276], 'Inc;': [1277], '1987.': [1278], 'pp': [1279, 1313], '273–282.': [1280], '25': [1281], 'Hallowes': [1282], 'Bone': [1284], 'Jones': [1286], 'new': [1289], 'dimension': [1290], 'culture': [1293, 1304], 'breast.': [1296], 'R': [1298], 'Richards,': [1299], 'K': [1300], 'Rajan,': [1301], 'Tissue': [1303], 'medical': [1306], 'research': [1307], '(II).': [1308], 'Oxford:': [1309], 'Pergamon': [1310], 'Press;': [1311], '1980.': [1312], '213–220.': [1314], '26': [1315], 'Fan': [1316], 'Pepicelli': [1318], 'CV,': [1319], 'Dibble': [1320], 'CC,': [1321], 'Zarycki': [1324], 'JL,': [1325], 'Gipp': [1328, 1462], 'Munoz': [1334], 'Lipinski': [1336, 1456], 'Thrasher': [1338], 'JB,': [1339], 'Hedgehog': [1342], 'promotes': [1344], 'xenograft': [1346], 'tumor': [1347, 1388], 'growth.': [1348], '2004;': [1350], '145(8):': [1351], '3961–3970.': [1352], '27': [1353], 'Sherr': [1354], 'CJ,': [1355], 'Roberts': [1356], 'JM.': [1357], 'Inhibitors': [1358], 'mammalian': [1360], 'G1': [1361], 'cyclin-dependent': [1362], 'kinases.': [1363], 'Genes': [1364], '9(10):': [1367], '1149–1163.': [1368], '28': [1369], 'Serrano': [1370], 'Chin': [1374], 'Cordon-Cardo': [1376], 'Beach': [1378], 'DePinho': [1380], 'RA.': [1381], 'Role': [1382], 'INK4a': [1385], 'locus': [1386], 'suppression': [1389], 'mortality.': [1392], '85(1):': [1395], '27–37.': [1396], '29': [1397], 'SA,': [1399], 'Schoumans': [1400], 'Looyenga': [1402], 'BD,': [1403], 'Yuhas': [1404], 'Zylstra': [1406], 'CR,': [1407], 'Koeman': [1408], 'JM,': [1409], 'Swiatek': [1410], 'PJ,': [1411], 'Teh': [1412], 'BT,': [1413], 'BO.': [1415], 'Spectral': [1416], 'karyotyping': [1417], 'sarcomas': [1419], 'derived': [1422], 'Ink4a/Arf-deficient': [1424], 'mice': [1425], 'reveals': [1426], 'chromosomal': [1427], 'instability': [1428], 'vitro.': [1430], 'Oncol': [1433], '2005;': [1434, 1486], '26(3):': [1435], '629–734.': [1436], '30': [1437], 'Tuxhorn': [1438], 'Ayala': [1440], 'GE,': [1441], 'Reactive': [1444], 'stroma': [1445], '166(6):': [1453], '2472–2483.': [1454], '31': [1455], 'Cook': [1458], 'CH,': [1459], 'JJ,': [1463], 'Peterson': [1464], 'RE,': [1465], 'regulates': [1471], 'insulin-like': [1475], 'binding': [1478], 'protein-6': [1479], 'Dyn': [1485], '233(3):': [1487], '829–836.': [1488], '32': [1489], 'Xin': [1490], 'Ide': [1492], 'Kim': [1494], 'Dubey': [1496], 'Witte': [1498], 'ON.': [1499], 'regeneration': [1502], 'dissociated': [1507], 'populations': [1509], 'postnatal': [1511], 'Proc': [1517], 'Natl': [1518], 'Acad': [1519], 'Sci': [1520], 'USA': [1521], '100(Suppl': [1523], '1):': [1524], '11896–11903.': [1525], 'Citing': [1526], 'Literature': [1527], 'Volume66,': [1528], 'Issue1315': [1529], 'September': [1530], '2006Pages': [1531], 'ReferencesRelatedInformation': [1533]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028464107', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T19:12:13.250501', 'created_date': '2016-06-24'}