Title: Evidence for antiradical and antioxidant properties of four biologically active N,N‐Diethylaminoethyl ethers of flavaone oximes: A comparison with natural polyphenolic flavonoid rutin action
Abstract: Abstract The antiradical and antioxidant activities of four biologically active N,N‐diethyloaminoethyl ethers of flavanone oximes (N,N‐DEAEFo) were investigated in vitro and compared with these of polyphenolic flavonoid (rutin). Four experimental models were used: iron‐ and ascorbate driven Fenton systems, γ‐radiolysis, xanthine/xanthine oxidase system and diphenylpicrylhydrazyl (DPPH) radical scavenging. The results clearly indicate that N,N‐DEAEFo are acting as promising antioxidants and radioprotectors comparable to rutin activities: they should prove to be useful under acute oxidative stress conditions for which both properties were required.