Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2028304990', 'doi': 'https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<390::aid-jcb6>3.0.co;2-q', 'title': 'Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription', 'display_name': 'Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription', 'publication_year': 1997, 'publication_date': '1997-03-01', 'ids': {'openalex': 'https://openalex.org/W2028304990', 'doi': 'https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<390::aid-jcb6>3.0.co;2-q', 'mag': '2028304990', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9057097'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<390::aid-jcb6>3.0.co;2-q', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072928202', 'display_name': 'Maha Μ. Gebara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maha M. Gebara', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032167858', 'display_name': 'Michael H. Sayre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael H. Sayre', 'raw_affiliation_strings': ['Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110114821', 'display_name': 'Jeffrey L. Corden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey L. Corden', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.269, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 81, 'citation_normalized_percentile': {'value': 0.844554, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '64', 'issue': '3', 'first_page': '390', 'last_page': '402'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-polymerase-ii', 'display_name': 'RNA polymerase II', 'score': 0.8218076}, {'id': 'https://openalex.org/keywords/cyclin-dependent-kinase-9', 'display_name': 'Cyclin-dependent kinase 9', 'score': 0.5806261}, {'id': 'https://openalex.org/keywords/general-transcription-factor', 'display_name': 'General transcription factor', 'score': 0.4869043}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.4517528}], 'concepts': [{'id': 'https://openalex.org/C64350747', 'wikidata': 'https://www.wikidata.org/wiki/Q15334993', 'display_name': 'RNA polymerase II', 'level': 5, 'score': 0.8218076}, {'id': 'https://openalex.org/C172768829', 'wikidata': 'https://www.wikidata.org/wiki/Q14817959', 'display_name': 'Transcription factor II D', 'level': 5, 'score': 0.7096499}, {'id': 'https://openalex.org/C196117886', 'wikidata': 'https://www.wikidata.org/wiki/Q21110340', 'display_name': 'RNA polymerase II holoenzyme', 'level': 5, 'score': 0.7039288}, {'id': 'https://openalex.org/C59143045', 'wikidata': 'https://www.wikidata.org/wiki/Q15314942', 'display_name': 'Cyclin-dependent kinase 9', 'level': 5, 'score': 0.5806261}, {'id': 'https://openalex.org/C105208137', 'wikidata': 'https://www.wikidata.org/wiki/Q425812', 'display_name': 'Transcription factor II B', 'level': 5, 'score': 0.5725386}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.55579853}, {'id': 'https://openalex.org/C154816499', 'wikidata': 'https://www.wikidata.org/wiki/Q21120535', 'display_name': 'Transcription factor II F', 'level': 5, 'score': 0.51170063}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.5092534}, {'id': 'https://openalex.org/C144825837', 'wikidata': 'https://www.wikidata.org/wiki/Q2316030', 'display_name': 'General transcription factor', 'level': 5, 'score': 0.4869043}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47475818}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.4517528}, {'id': 'https://openalex.org/C156951783', 'wikidata': 'https://www.wikidata.org/wiki/Q21110793', 'display_name': 'Transcription factor II E', 'level': 5, 'score': 0.4232571}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41772583}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.4106425}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.32546234}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.29021475}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.21313575}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21091735}, {'id': 'https://openalex.org/C41258723', 'wikidata': 'https://www.wikidata.org/wiki/Q2919111', 'display_name': 'RNA-dependent RNA polymerase', 'level': 4, 'score': 0.19888204}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.1749374}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.13436928}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.12858284}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.058719903}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012319', 'descriptor_name': 'RNA Polymerase II', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D012319', 'descriptor_name': 'RNA Polymerase II', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012319', 'descriptor_name': 'RNA Polymerase II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<390::aid-jcb6>3.0.co;2-q', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9057097', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1497435365', 'https://openalex.org/W1512828307', 'https://openalex.org/W1514266791', 'https://openalex.org/W1524975259', 'https://openalex.org/W1532893184', 'https://openalex.org/W1533728933', 'https://openalex.org/W1546294341', 'https://openalex.org/W1550970695', 'https://openalex.org/W1551469893', 'https://openalex.org/W1564650554', 'https://openalex.org/W1577115462', 'https://openalex.org/W1578647589', 'https://openalex.org/W1581840018', 'https://openalex.org/W1594857663', 'https://openalex.org/W1606267994', 'https://openalex.org/W1641093167', 'https://openalex.org/W1954289976', 'https://openalex.org/W1965376325', 'https://openalex.org/W1970446592', 'https://openalex.org/W1975948611', 'https://openalex.org/W1977694232', 'https://openalex.org/W1981451485', 'https://openalex.org/W1986421128', 'https://openalex.org/W1996072788', 'https://openalex.org/W2002806722', 'https://openalex.org/W2004796688', 'https://openalex.org/W2012430176', 'https://openalex.org/W2014427312', 'https://openalex.org/W2017393438', 'https://openalex.org/W2022517270', 'https://openalex.org/W2026715418', 'https://openalex.org/W2027376766', 'https://openalex.org/W2028703908', 'https://openalex.org/W2030180039', 'https://openalex.org/W2035091026', 'https://openalex.org/W2039068784', 'https://openalex.org/W2056277197', 'https://openalex.org/W2058144279', 'https://openalex.org/W2063213781', 'https://openalex.org/W2069875752', 'https://openalex.org/W2075431354', 'https://openalex.org/W2077844248', 'https://openalex.org/W2080176881', 'https://openalex.org/W2085946671', 'https://openalex.org/W2087732988', 'https://openalex.org/W2088163601', 'https://openalex.org/W2091250415', 'https://openalex.org/W2094973595', 'https://openalex.org/W2095215072', 'https://openalex.org/W2100419380', 'https://openalex.org/W2101095087', 'https://openalex.org/W2105495356', 'https://openalex.org/W2111953151', 'https://openalex.org/W2124019856', 'https://openalex.org/W2136105013', 'https://openalex.org/W2142731245', 'https://openalex.org/W2169295539', 'https://openalex.org/W2170519372', 'https://openalex.org/W218149522', 'https://openalex.org/W222591440', 'https://openalex.org/W2318642656', 'https://openalex.org/W236095070', 'https://openalex.org/W2408883842', 'https://openalex.org/W4237296558'], 'related_works': ['https://openalex.org/W4388253090', 'https://openalex.org/W2157087271', 'https://openalex.org/W2063296736', 'https://openalex.org/W2039675129', 'https://openalex.org/W2026537834', 'https://openalex.org/W2005097302', 'https://openalex.org/W2004796688', 'https://openalex.org/W1977439656', 'https://openalex.org/W1972091887', 'https://openalex.org/W1605064581'], 'abstract_inverted_index': {'Cdc2': [0, 25, 54, 82, 96, 134], 'kinase': [1, 26, 86, 97, 135, 155], 'triggers': [2], 'the': [3, 10, 30, 37, 48, 85, 91, 112, 131, 152, 192], 'entry': [4], 'of': [5, 29, 50, 130, 148, 165, 191], 'mammalian': [6], 'cells': [7], 'into': [8], 'mitosis,': [9], 'only': [11], 'cell': [12], 'cycle': [13], 'phase': [14], 'in': [15, 60, 111, 119, 124, 182, 205], 'which': [16], 'transcription': [17, 34, 62, 113, 138, 159, 204, 208], 'is': [18, 65, 180], 'globally': [19], 'repressed.': [20], 'We': [21], 'show': [22, 145], 'here': [23], 'that': [24, 64, 72, 84, 106, 128, 146, 176, 189], 'phosphorylates': [27], 'components': [28], 'RNA': [31, 38, 69, 103, 115, 177], 'polymerase': [32, 39, 70, 104, 116, 178], 'II': [33, 40, 71, 150], 'machinery': [35], 'including': [36], 'carboxy-terminal': [41], 'repeat': [42], 'domain': [43], '(CTD).': [44], 'To': [45], 'test': [46], 'specifically': [47], 'effect': [49], 'CTD': [51, 132, 166, 193], 'phosphorylation': [52, 129, 147, 167, 190], 'by': [53, 133, 168, 194], 'kinase,': [55], 'we': [56, 144, 187], 'used': [57, 99], 'a': [58, 74, 162, 206], 'yeast': [59], 'vitro': [61], 'extract': [63], 'dependent': [66], 'on': [67], 'exogenous': [68], 'contains': [73], 'CTD.': [75], 'Phosphorylation': [76], 'was': [77, 107, 122], 'carried': [78], 'out': [79], 'using': [80], 'immobilized': [81], 'so': [83], 'could': [87], 'be': [88], 'removed': [89], 'from': [90], 'phosphorylated': [92], 'polymerase.': [93], 'ATPγS': [94], 'and': [95], 'were': [98], 'to': [100], 'produce': [101], 'an': [102], '110': [105, 117, 179], 'not': [108], 'detectably': [109], 'dephosphorylated': [110], 'extract.': [114], 'produced': [118], 'this': [120, 169], 'way': [121], 'defective': [123, 181], 'promoter-dependent': [125], 'transcription,': [126], 'suggesting': [127], 'can': [136, 202], 'mediate': [137], 'repression': [139], 'during': [140], 'mitosis.': [141], 'In': [142], 'addition,': [143], 'pol': [149], 'with': [151, 197], 'human': [153], 'TFIIH-associated': [154], 'Cdk7': [156], 'also': [157], 'decreases': [158], 'activity': [160], 'despite': [161], 'different': [163, 198], 'pattern': [164], 'kinase.': [170], 'These': [171], 'results': [172], 'extend': [173], 'previous': [174], 'findings': [175], 'preinitiation': [183], 'complex': [184], 'formation.': [185], 'Here': [186], 'demonstrate': [188], 'cyclin-dependent': [195], 'kinases': [196], 'phosphoryl': [199], 'acceptor': [200], 'specificities': [201], 'inhibit': [203], 'CTD-dependent': [207], 'system.': [209], 'J.': [210], 'Cell.': [211], 'Biochem.': [212], '64:390–402.': [213], '©': [214], '1997': [215], 'Wiley-Liss,': [216], 'Inc.': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028304990', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-12T01:28:02.690999', 'created_date': '2016-06-24'}