Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2028259923', 'doi': 'https://doi.org/10.1016/j.mod.2006.08.010', 'title': 'Xenopus cadherin-6 regulates growth and epithelial development of the retina', 'display_name': 'Xenopus cadherin-6 regulates growth and epithelial development of the retina', 'publication_year': 2006, 'publication_date': '2006-09-02', 'ids': {'openalex': 'https://openalex.org/W2028259923', 'doi': 'https://doi.org/10.1016/j.mod.2006.08.010', 'mag': '2028259923', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17034995'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mod.2006.08.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137434647', 'display_name': 'Mechanisms of Development', 'issn_l': '0925-4773', 'issn': ['0925-4773', '1872-6356'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038545409', 'display_name': 'Gui Ruan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102335020', 'display_name': 'Karlsruhe Institute of Technology', 'ror': 'https://ror.org/04t3en479', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I102335020', 'https://openalex.org/I1305996414']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Gui Ruan', 'raw_affiliation_strings': ['University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany'], 'affiliations': [{'raw_affiliation_string': 'University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany', 'institution_ids': ['https://openalex.org/I102335020']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052358604', 'display_name': 'Doris Wedlich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102335020', 'display_name': 'Karlsruhe Institute of Technology', 'ror': 'https://ror.org/04t3en479', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I102335020', 'https://openalex.org/I1305996414']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Doris Wedlich', 'raw_affiliation_strings': ['University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany'], 'affiliations': [{'raw_affiliation_string': 'University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany', 'institution_ids': ['https://openalex.org/I102335020']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073475812', 'display_name': 'Almut Köhler', 'orcid': 'https://orcid.org/0000-0002-7575-0602'}, 'institutions': [{'id': 'https://openalex.org/I102335020', 'display_name': 'Karlsruhe Institute of Technology', 'ror': 'https://ror.org/04t3en479', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I102335020', 'https://openalex.org/I1305996414']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Almut Koehler', 'raw_affiliation_strings': ['University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany'], 'affiliations': [{'raw_affiliation_string': 'University of Karlsruhe (TH), Institute of Zoology II, Karlsruhe, Germany', 'institution_ids': ['https://openalex.org/I102335020']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.651, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.593582, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '123', 'issue': '12', 'first_page': '881', 'last_page': '892'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Molecular Mechanisms of Retinal Degeneration and Regeneration', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuroepithelial-cell', 'display_name': 'Neuroepithelial cell', 'score': 0.7760917}, {'id': 'https://openalex.org/keywords/neural-development', 'display_name': 'Neural Development', 'score': 0.48899}], 'concepts': [{'id': 'https://openalex.org/C2777093970', 'wikidata': 'https://www.wikidata.org/wiki/Q169342', 'display_name': 'Retina', 'level': 2, 'score': 0.8037245}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.79331255}, {'id': 'https://openalex.org/C200707615', 'wikidata': 'https://www.wikidata.org/wiki/Q13652744', 'display_name': 'Neuroepithelial cell', 'level': 4, 'score': 0.7760917}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.65557337}, {'id': 'https://openalex.org/C2781334511', 'wikidata': 'https://www.wikidata.org/wiki/Q108158', 'display_name': 'Ganglion', 'level': 2, 'score': 0.5382393}, {'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.52055913}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.4744117}, {'id': 'https://openalex.org/C114696181', 'wikidata': 'https://www.wikidata.org/wiki/Q5422650', 'display_name': 'Eye development', 'level': 4, 'score': 0.46376038}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.44947168}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.43446785}, {'id': 'https://openalex.org/C461258', 'wikidata': 'https://www.wikidata.org/wiki/Q1345738', 'display_name': 'Neural development', 'level': 3, 'score': 0.42365015}, {'id': 'https://openalex.org/C529295009', 'wikidata': 'https://www.wikidata.org/wiki/Q41301', 'display_name': 'Epithelium', 'level': 2, 'score': 0.41934142}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.31050876}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.26667047}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.14823037}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.1205858}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.10361582}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09056109}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005124', 'descriptor_name': 'Eye Abnormalities', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016376', 'descriptor_name': 'Oligonucleotides, Antisense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016376', 'descriptor_name': 'Oligonucleotides, Antisense', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D012160', 'descriptor_name': 'Retina', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mod.2006.08.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137434647', 'display_name': 'Mechanisms of Development', 'issn_l': '0925-4773', 'issn': ['0925-4773', '1872-6356'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17034995', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'score': 0.52, 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1519525474', 'https://openalex.org/W1837219479', 'https://openalex.org/W1901437611', 'https://openalex.org/W1965063265', 'https://openalex.org/W1967751087', 'https://openalex.org/W1968652803', 'https://openalex.org/W1980513503', 'https://openalex.org/W1983547918', 'https://openalex.org/W1984634814', 'https://openalex.org/W1985020131', 'https://openalex.org/W1988567128', 'https://openalex.org/W2000662684', 'https://openalex.org/W2005835439', 'https://openalex.org/W2014843193', 'https://openalex.org/W2017771872', 'https://openalex.org/W2023618495', 'https://openalex.org/W2025848493', 'https://openalex.org/W2031779270', 'https://openalex.org/W2042769067', 'https://openalex.org/W2045344258', 'https://openalex.org/W2045469321', 'https://openalex.org/W2051747697', 'https://openalex.org/W2061128706', 'https://openalex.org/W2068764375', 'https://openalex.org/W2070412516', 'https://openalex.org/W2084457841', 'https://openalex.org/W2085279936', 'https://openalex.org/W2092096245', 'https://openalex.org/W2103098500', 'https://openalex.org/W2107976817', 'https://openalex.org/W2126245868', 'https://openalex.org/W2127312018', 'https://openalex.org/W2133890761', 'https://openalex.org/W2141834663', 'https://openalex.org/W2144127727', 'https://openalex.org/W2146098038', 'https://openalex.org/W2146404892', 'https://openalex.org/W2161923924', 'https://openalex.org/W2214673052', 'https://openalex.org/W2266492038', 'https://openalex.org/W2328269288', 'https://openalex.org/W2345376761', 'https://openalex.org/W2470956167', 'https://openalex.org/W4234629582'], 'related_works': ['https://openalex.org/W2396603739', 'https://openalex.org/W2318477895', 'https://openalex.org/W2153949047', 'https://openalex.org/W2055261759', 'https://openalex.org/W2028481169', 'https://openalex.org/W1993888492', 'https://openalex.org/W1980985436', 'https://openalex.org/W1980513503', 'https://openalex.org/W1976709352', 'https://openalex.org/W185558933'], 'abstract_inverted_index': {'Cadherins': [0], 'are': [1], 'crucial': [2], 'for': [3, 124], 'tissue': [4], 'cohesion,': [5], 'separation': [6], 'of': [7, 19, 49, 68, 103, 129], 'cell': [8, 11, 57, 106], 'layers': [9], 'and': [10, 53, 109, 127, 138], 'migration': [12], 'during': [13], 'embryogenesis.': [14], 'To': [15], 'investigate': [16], 'the': [17, 47, 96, 104, 130], 'role': [18], 'classical': [20], 'type': [21], 'II': [22], 'Xcadherin-6': [23, 69, 89, 117], '(Xcad-6),': [24], 'we': [25], 'performed': [26], 'loss-of-function': [27], 'studies': [28], 'by': [29], 'morpholino': [30], 'oligonucleotide': [31], 'injections.': [32], 'This': [33], 'resulted': [34], 'in': [35, 56, 81, 95, 121], 'severe': [36], 'eye': [37, 62, 122], 'defects': [38, 94], 'which': [39], 'could': [40], 'be': [41], 'rescued': [42], 'with': [43, 61], 'murine': [44], 'cadherin-6.': [45], 'In': [46], 'absence': [48], 'Xcadherin-6,': [50], 'morphological': [51], 'alterations': [52], 'a': [54, 78, 82, 100, 110], 'decrease': [55], 'proliferation': [58], 'were': [59], 'observed': [60], 'cup': [63], 'formation.': [64], 'Eye': [65], 'field': [66], 'transplantations': [67], 'depleted': [70], 'donors': [71], 'yielded': [72], 'grafts': [73], 'that': [74], 'failed': [75], 'to': [76], 'form': [77], 'proper': [79], 'neuroepithelium': [80, 131], 'wildtype': [83], 'environment.': [84], 'At': [85], 'later': [86], 'developmental': [87], 'stages': [88], 'deficient': [90], 'eyes': [91], 'showed': [92], 'lamination': [93], 'outer': [97], 'neural': [98, 136], 'retina,': [99], 'reduced': [101], 'thickness': [102], 'ganglion': [105], 'layer': [107], '(GCL)': [108], 'fragmented': [111], 'retina': [112, 137], 'pigment': [113], 'epithelium': [114], '(RPE).': [115], 'Thus,': [116], 'is': [118], 'essential': [119], 'early': [120], 'development': [123], 'structural': [125], 'organization': [126], 'growth': [128], 'before': [132], 'it': [133], 'differentiates': [134], 'into': [135], 'RPE.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028259923', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-17T15:30:37.955793', 'created_date': '2016-06-24'}