Title: Sensitization of c-fos expression in rat striatum following multiple challenges withd-amphetamine
Abstract: d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei.d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously withd-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration ofd-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.
Publication Year: 1993
Publication Date: 1993-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 31
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