Title: Effects of Substance P and Substance P-(6–ll) on Hormone Release from Isolated Perfused Pancreas: Their Opposite Actions on Rat and Canine Islets*
Abstract: The effects of substance P (SP) and SP-(6–ll) (SP6–11) on hormone secretion from the isolated perfused pancreas were compared in rats and dogs under the same conditions. In the rat, SP inhibited insulin secretion in a dose-dependent manner in a concentration range of 0.1–10 nm. Glucagon secretion was inhibited at a minimal dose of 10 nm SP. No significant effect on somatostatin secretion was obtained. SP6–11 exhibited the identical inhibitory potency as SP on both insulin and glucagon release from the rat pancreas. In the canine pancreas, by contrast, 1 and 10 nm SP and SP6–11, respectively, potentiated the release of insulin, glucagon, and somatostatin. Potentiation by SP6–11 was less than that by SP. These results demonstrate species differences in the effects of SP and SP6–11 on the release of pancreatic hormones. (Endocrinology117: 1996–2000, 1985)
Publication Year: 1985
Publication Date: 1985-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 26
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