Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2027628757', 'doi': 'https://doi.org/10.1016/s0014-2999(00)00837-2', 'title': 'Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter', 'display_name': 'Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter', 'publication_year': 2000, 'publication_date': '2000-12-01', 'ids': {'openalex': 'https://openalex.org/W2027628757', 'doi': 'https://doi.org/10.1016/s0014-2999(00)00837-2', 'mag': '2027628757', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11099697'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-2999(00)00837-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034023731', 'display_name': 'Yuichi Uwai', 'orcid': 'https://orcid.org/0000-0002-2973-0969'}, 'institutions': [{'id': 'https://openalex.org/I4210150196', 'display_name': 'Kyoto University Hospital', 'ror': 'https://ror.org/04k6gr834', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150196']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuichi Uwai', 'raw_affiliation_strings': ['Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I4210150196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101664787', 'display_name': 'Hideyuki Saito', 'orcid': 'https://orcid.org/0000-0001-6522-7300'}, 'institutions': [{'id': 'https://openalex.org/I4210150196', 'display_name': 'Kyoto University Hospital', 'ror': 'https://ror.org/04k6gr834', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150196']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideyuki Saito', 'raw_affiliation_strings': ['Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I4210150196']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109986673', 'display_name': 'Ken-ichi Inui', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150196', 'display_name': 'Kyoto University Hospital', 'ror': 'https://ror.org/04k6gr834', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150196']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ken-ichi Inui', 'raw_affiliation_strings': ['Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I4210150196']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.47, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.945987, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '409', 'issue': '1', 'first_page': '31', 'last_page': '36'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11964', 'display_name': 'Pregnancy and Medication Impact', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11964', 'display_name': 'Pregnancy and Medication Impact', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/probenecid', 'display_name': 'Probenecid', 'score': 0.99051917}, {'id': 'https://openalex.org/keywords/antifolate', 'display_name': 'Antifolate', 'score': 0.6562083}, {'id': 'https://openalex.org/keywords/organic-anion', 'display_name': 'Organic anion', 'score': 0.6258301}], 'concepts': [{'id': 'https://openalex.org/C2776769776', 'wikidata': 'https://www.wikidata.org/wiki/Q900898', 'display_name': 'Probenecid', 'level': 2, 'score': 0.99051917}, {'id': 'https://openalex.org/C123584848', 'wikidata': 'https://www.wikidata.org/wiki/Q18034026', 'display_name': 'Organic anion transporter 1', 'level': 4, 'score': 0.894534}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.8804455}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7538289}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7066807}, {'id': 'https://openalex.org/C2781382166', 'wikidata': 'https://www.wikidata.org/wiki/Q50573407', 'display_name': 'Antifolate', 'level': 4, 'score': 0.6562083}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.65371}, {'id': 'https://openalex.org/C121421483', 'wikidata': 'https://www.wikidata.org/wiki/Q43457632', 'display_name': 'Organic anion', 'level': 3, 'score': 0.6258301}, {'id': 'https://openalex.org/C97320921', 'wikidata': 'https://www.wikidata.org/wiki/Q718753', 'display_name': 'Drug interaction', 'level': 3, 'score': 0.45898023}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.30741346}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26866174}, {'id': 'https://openalex.org/C2778397455', 'wikidata': 'https://www.wikidata.org/wiki/Q50429865', 'display_name': 'Antimetabolite', 'level': 3, 'score': 0.25984162}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23263347}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1714293}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.07171297}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027321', 'descriptor_name': 'Anion Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011339', 'descriptor_name': 'Probenecid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011339', 'descriptor_name': 'Probenecid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014528', 'descriptor_name': 'Uricosuric Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014528', 'descriptor_name': 'Uricosuric Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-2999(00)00837-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11099697', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.46, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W148893073', 'https://openalex.org/W1861114473', 'https://openalex.org/W1954218272', 'https://openalex.org/W1965076953', 'https://openalex.org/W1966641649', 'https://openalex.org/W1995000196', 'https://openalex.org/W1996402420', 'https://openalex.org/W2027388151', 'https://openalex.org/W2033596995', 'https://openalex.org/W2049320217', 'https://openalex.org/W2051860402', 'https://openalex.org/W2067650742', 'https://openalex.org/W2082188851', 'https://openalex.org/W2083208920', 'https://openalex.org/W2114414164', 'https://openalex.org/W2124363222', 'https://openalex.org/W2223838313', 'https://openalex.org/W2254513038', 'https://openalex.org/W2403776894', 'https://openalex.org/W2406692965', 'https://openalex.org/W2413290861', 'https://openalex.org/W3184260731', 'https://openalex.org/W4317926315'], 'related_works': ['https://openalex.org/W58520562', 'https://openalex.org/W4385164212', 'https://openalex.org/W3084432786', 'https://openalex.org/W2282034295', 'https://openalex.org/W2163787840', 'https://openalex.org/W2152702915', 'https://openalex.org/W2070133422', 'https://openalex.org/W2033670502', 'https://openalex.org/W2027628757', 'https://openalex.org/W2013676933'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2027628757', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-05T09:42:11.107154', 'created_date': '2016-06-24'}