Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors

Name: Work Video:
Duration: 3 min 30 s
Kenneth C. Malcolm; G. Scott Worthen
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'https://openalex.org/W88943984'], 'related_works': ['https://openalex.org/W2929186841', 'https://openalex.org/W2526524223', 'https://openalex.org/W2415579033', 'https://openalex.org/W2272812725', 'https://openalex.org/W2130840482', 'https://openalex.org/W2115850341', 'https://openalex.org/W2023142724', 'https://openalex.org/W2021996518', 'https://openalex.org/W1992340888', 'https://openalex.org/W1987143582'], 'abstract_inverted_index': {'Lipopolysaccharide': [0, 242], '(LPS)': [1, 243], 'induces': [2, 244, 3924], 'neutrophils': [3, 26, 59, 70, 201, 225, 238, 245, 268, 301, 312, 443, 467, 480, 538, 575, 606, 1129, 1432, 1630, 1649, 2085, 2093, 2271, 2290, 2938, 2956, 3023, 3320, 3793, 3815, 3853, 3876, 3890, 3923, 4046, 4070, 4110, 4162, 4277, 4282, 4301, 4329], 'to': [4, 38, 60, 93, 116, 182, 239, 246, 280, 302, 335, 358, 424, 481, 526, 580, 585, 587, 678, 988, 1171, 1443, 1707, 1731, 1850, 1865, 1918, 1958, 2023, 2090, 2105, 2143, 2249, 2620, 3165, 3485, 3611, 3745, 3791, 3795, 4047, 4071, 4079, 4096, 4253, 4280, 4347, 4353], 'synthesize': [5, 247], 'and': [6, 10, 19, 80, 84, 86, 130, 153, 202, 226, 248, 252, 261, 322, 326, 328, 372, 395, 444, 468, 501, 532, 576, 595, 611, 614, 619, 627, 686, 701, 760, 1155, 1187, 1378, 1445, 1452, 1597, 1721, 1778, 1784, 1856, 1860, 1871, 1875, 1914, 1948, 1964, 2124, 2147, 2160, 2167, 2280, 2291, 2306, 2327, 2334, 2339, 2382, 2391, 2484, 2535, 2541, 2610, 2612, 2692, 2694, 2720, 2739, 2874, 2916, 2968, 2998, 3051, 3092, 3128, 3152, 3167, 3210, 3229, 3243, 3271, 3303, 3353, 3477, 3493, 3508, 3510, 3514, 3526, 3563, 3584, 3588, 3779, 3810, 3816, 3864, 3874, 3896, 4027, 4030, 4034, 4052, 4171, 4275, 4286, 4291], 'secrete': [7, 249, 2101, 2119], 'pro-inflammatory': [8, 250], 'cytokines': [9, 251, 613, 3483], 'chemokines,': [11, 253, 615], 'which': [12, 254, 621, 1723, 2084], 'are': [13, 255, 607, 622, 1615, 1939, 2150, 2285, 3385, 3466, 3911, 3932, 4359], 'regulated': [14, 256, 1940, 3844, 3942], 'at': [15, 257, 682, 2596, 2615, 3020, 3125, 3132, 3139, 3248, 3566, 3590], 'both': [16, 258, 683, 2158, 4086, 4102], 'the': [17, 64, 74, 123, 171, 259, 306, 316, 365, 413, 520, 549, 583, 684, 697, 703, 767, 989, 992, 1151, 1365, 1433, 1447, 1643, 1711, 1716, 1733, 1767, 1770, 1851, 1858, 1866, 1869, 1923, 1931, 1949, 1973, 2071, 2081, 2129, 2254, 2604, 2647, 2753, 2928, 3040, 3170, 3390, 3423, 3460, 3528, 3571, 3603, 3636, 3661, 3750, 3759, 3797, 3831, 3837, 3849, 3870, 3894, 3903, 3917, 3976, 4038, 4058, 4081, 4121, 4155, 4172, 4262], 'transcriptional': [18, 260, 685, 993, 1159, 1774, 1943, 3980], 'translational': [20, 262, 687], 'level.': [21, 263, 688], 'We': [22, 264, 2026, 3311, 4312], 'reported': [23, 265], 'previously': [24, 266, 2352, 2492], 'that': [25, 55, 217, 227, 267, 297, 459, 469, 605, 764, 2282, 3381, 3436, 3702, 3761, 3852, 3884, 3907, 3919, 3928, 4163, 4201, 4264, 4307, 4343], 'stimulated': [27, 269, 2942, 2984, 3038, 3177, 4154], 'with': [28, 40, 270, 282, 590, 2512, 2603, 2690, 2910, 2946, 2976, 2988, 2993, 3118, 3169, 3191, 3224, 3322, 3387, 3536, 3646, 3830, 4111, 4214], 'LPS': [29, 105, 176, 271, 347, 418, 581, 679, 769, 983, 1184, 1444, 1978, 2134, 2288, 2294, 2949, 3323, 3456, 3561, 3575, 3591, 3608, 3641, 3652, 3742, 3762, 3819, 3920, 4048, 4072, 4153, 4202, 4344, 4371], 'induce': [30, 272, 1959, 2086, 2106, 4254], 'expression': [31, 109, 124, 197, 273, 351, 366, 439, 1152, 1582, 1644, 1781, 2018, 3317, 3427, 3461, 3474, 3531, 3538, 3552, 3581, 3822, 3838, 4168, 4204, 4287], 'of': [32, 58, 66, 82, 110, 140, 155, 173, 198, 229, 235, 237, 274, 300, 308, 324, 352, 382, 397, 415, 440, 471, 477, 479, 503, 528, 537, 543, 546, 574, 592, 597, 672, 699, 705, 991, 1153, 1369, 1390, 1449, 1576, 1580, 1618, 1622, 1637, 1645, 1713, 1735, 1761, 1769, 1773, 1782, 1868, 1911, 1926, 1945, 1952, 1975, 2073, 2131, 2145, 2163, 2257, 2270, 2481, 2553, 2607, 2649, 2795, 2857, 2869, 2914, 2965, 2971, 3005, 3056, 3194, 3266, 3284, 3290, 3377, 3422, 3426, 3429, 3455, 3459, 3462, 3475, 3504, 3512, 3524, 3530, 3574, 3582, 3602, 3622, 3629, 3638, 3651, 3663, 3752, 3783, 3800, 3833, 3839, 3872, 3886, 3893, 3898, 3922, 3937, 3979, 3985, 4045, 4060, 4069, 4085, 4093, 4101, 4109, 4123, 4157, 4174, 4205, 4216, 4288, 4308, 4364], 'genes': [33, 231, 275, 473, 629, 1647, 1714, 1737, 1928, 3378, 3465, 3480, 3926], 'typically': [34, 276], 'expressed': [35, 277, 3487], 'in': [36, 63, 151, 177, 189, 200, 224, 278, 305, 393, 419, 431, 442, 466, 519, 676, 696, 702, 710, 996, 1149, 1165, 1182, 1190, 1384, 1387, 1431, 1441, 1578, 1624, 1629, 1648, 1725, 1904, 1922, 1955, 2021, 2075, 2088, 2112, 2135, 2272, 2289, 2526, 2685, 2699, 2707, 2725, 2908, 2962, 3010, 3045, 3053, 3149, 3154, 3198, 3251, 3315, 3318, 3382, 3468, 3488, 3767, 3869, 3888, 3914, 3943, 4042, 4120, 4161, 4351], 'response': [37, 57, 279, 299, 523, 677, 1442, 1706, 1933, 2022, 2089, 3701], 'stimulation': [39, 281, 3576, 3859, 3921, 4092], 'antiviral': [41, 230, 283, 472, 1950, 1965, 2016, 2278], 'type': [42, 284, 1717, 3391, 3664, 3753, 3899, 3908], 'I': [43, 285, 1718, 3392, 3665, 3754, 3900, 3909], 'interferons': [44, 286, 3666, 3910], '(IFN),': [45, 287], 'such': [46, 288, 616, 1936, 3464], 'as': [47, 289, 617, 1930, 1937, 2311, 2350, 2490, 2760, 2808, 2876, 2925, 3030, 3146, 3555, 3557, 3593, 3595], 'myxovirus': [48, 290], 'resistance-1': [49, 291], '(MX1).': [50, 292], 'However,': [51, 293, 1430, 1635, 3862, 4247], 'we': [52, 294, 2079, 3757, 4150], 'present': [53, 295], 'evidence': [54, 296], 'this': [56, 298, 1946, 2014, 2252, 3220], 'lipopolysaccharide': [61, 218, 303, 460, 484, 554], 'occurs': [62, 304], 'absence': [65, 307], 'interferon-dependent': [67, 309], 'signaling.': [68, 310], 'Lipopolysaccharide-stimulated': [69, 311], 'do': [71, 313, 2094], 'not': [72, 102, 107, 149, 164, 192, 210, 314, 344, 349, 391, 406, 434, 452, 1632, 2095, 2138, 2155, 3655, 3825, 3867, 3878, 3912, 4056, 4114, 4126, 4198, 4257, 4306, 4314, 4335, 4360], 'phosphorylate': [73, 315, 2109, 2125], 'interferon-associated': [75, 317], 'transcription': [76, 318, 504, 513, 1176, 1588, 1592, 1627, 1873, 2853, 3895], 'factors': [77, 319, 1628, 1874, 4266, 4358], 'signal': [78, 320, 499], 'transducer': [79, 321, 500], 'activator': [81, 323, 502], 'transcription-1': [83, 325], '–3,': [85, 327], 'medium': [87, 131, 329, 373, 2528, 2701, 2732, 2967, 4298, 4326], 'from': [88, 132, 330, 374, 1167, 2295, 2302, 2331, 2342, 2373, 2387, 2394, 2400, 2478, 2679, 2752, 2843, 2861, 2871, 2937, 3176, 3184, 3219, 3814, 4222, 4273, 4299, 4320, 4327], 'lipopolysaccharide-stimulated': [89, 331], 'cells': [90, 332, 579, 610, 1191, 2514, 2587, 2678, 2698, 2715, 2722, 2953, 3178, 3669, 4094, 4355], 'was': [91, 128, 157, 180, 333, 370, 399, 422, 2300, 2318, 2348, 2371, 2399, 2733, 2806, 2849, 2918, 3001, 3028, 3232, 3246, 3292, 3305, 3450, 3494, 3553, 3564, 3586, 3642, 4076, 4293], 'unable': [92, 334], 'induceMX1': [94, 336, 4348], 'gene': [95, 337, 491, 1581, 1780, 2017, 2099, 3316, 3821, 3847], 'expression,': [96, 338, 2100, 2118, 3848], 'suggesting': [97, 339], 'a': [98, 233, 340, 475, 516, 942, 985, 1146, 1381, 1388, 1909, 1919, 2102, 2120, 2266, 2487, 2550, 3011, 3109, 3297, 3442, 3619, 3700, 3775, 3788, 4097, 4158], 'soluble': [99, 341, 2103, 2121], 'factor': [100, 342, 489, 1177, 1902, 4160, 4318], 'is': [101, 187, 205, 232, 343, 429, 447, 474, 602, 680, 694, 766, 1179, 1438, 1583, 1908, 2019, 2141, 2253, 2515, 2549, 3743, 3842, 3891, 3941, 4219, 4330, 4345], 'involved.': [103, 345], 'Furthermore,': [104, 346, 2128, 3635, 3806], 'did': [106, 348, 4055], 'alter': [108, 350], 'IFNAand': [111, 353], 'IFNB': [112, 127, 354, 369, 1785, 2098, 2117, 3766, 3784, 3809], 'genes.': [113, 355], 'In': [114, 169, 356, 411, 599, 1169, 1971, 2013, 2623, 3472, 3549, 3769, 4089, 4366], 'contrast': [115, 357, 1170, 4352], 'neutrophils,': [117, 152, 359, 394, 2136, 2865, 3490, 3771, 3916], 'LPS-stimulated': [118, 133, 190, 360, 375, 432, 2092, 3489, 3668, 3875, 3889, 4276, 4300, 4321, 4328], 'human': [119, 361, 2681, 2729, 3319, 4249], 'monocyte-derived': [120, 134, 178, 194, 203, 362, 376, 420, 436, 445, 2114, 2139, 2292, 2872, 2940, 3007], 'macrophages': [121, 135, 179, 204, 363, 377, 421, 446, 2115, 2643, 2873, 2941, 2982, 3008, 3143], 'induced': [122, 364, 3544, 3606, 3613, 3763, 4302], 'ofMX1,': [125, 367], 'but': [126, 148, 163, 191, 209, 368, 390, 405, 433, 451, 2137, 2154, 3542, 4113, 4125, 4305, 4350], 'induced,': [129, 371], 'supported': [136, 378], 'MX1induction.': [137, 379], 'An': [138, 380], 'inhibitor': [139, 381, 3650], 'p38': [141, 183, 186, 383, 425, 428, 1434, 1577, 1623, 1638], 'kinase': [142, 384, 498, 1367, 1436, 3244], 'blocked': [143, 385, 3643], 'induction': [144, 154, 172, 228, 386, 396, 414, 470, 1712, 1734, 1974, 2130, 2162, 2260, 3439, 3449, 3637, 3751, 3832, 3885, 3936, 4363, 4374], 'ofMX1': [145, 387], 'by': [146, 175, 207, 388, 417, 449, 524, 541, 625, 1764, 1776, 1942, 1977, 2083, 2133, 2152, 2165, 2261, 2275, 2287, 2313, 2320, 2324, 2646, 2718, 2802, 2851, 2920, 2927, 3130, 3162, 3282, 3389, 3432, 3518, 3533, 3607, 3614, 3640, 3644, 3667, 3818, 3820, 3845, 3860, 3939, 3945, 3982, 4295, 4370], 'lipopolysaccharide,': [147, 389], 'IFNα,': [150, 165, 392, 407, 4112], 'MX1': [156, 174, 199, 398, 416, 441, 3507, 3525, 3583, 3605, 3639, 4255, 4309], 'dependent': [158, 400], 'on': [159, 401, 1642, 2486, 3099, 3205, 3296, 3705, 3987], 'protein': [160, 402, 497, 511, 1763, 2309, 2555, 3230, 3841, 3857], 'synthesis.': [161, 403], 'LPS,': [162, 404, 2608, 3792, 4115], 'substantially': [166, 408], 'activated': [167, 409, 1440, 2286], 'p38.': [168, 410, 1619], 'contrast,': [170, 412, 2113, 3473, 3550, 4090], 'insensitive': [181, 423], 'inhibition,': [184, 426], 'although': [185, 427, 937, 1587, 4324], 'phosphorylated': [188, 430], 'IFNα-stimulated': [193, 435], 'macrophages.': [195, 437, 2293], 'The': [196, 212, 438, 454, 689, 1574, 1620, 1704, 1899, 2731, 3217, 3239, 3580, 3934], 'mediated': [206, 448, 2151], 'TLR4': [208, 450, 765, 2153, 3706], 'TLR2.': [211, 453, 2156], 'data': [213, 455, 762, 2264, 3882, 3904, 4170, 4173, 4341], 'presented': [214, 456], 'here': [215, 457], 'indicate': [216, 458, 3883, 3906, 4342], 'activates': [219, 461, 1185, 1857], 'novel': [220, 462], 'interferon-independent': [221, 463, 3935], 'signaling': [222, 464, 707, 1166, 3653, 3930], 'pathways': [223, 465, 708, 2284, 3931], 'consequence': [234, 476], 'exposure': [236, 478, 3562, 3790], 'bacterial': [240, 482, 550, 2024], 'products.': [241, 483], 'double-stranded': [485], 'RNA': [486, 2797, 2870], 'interferon': [487], 'IFN-regulatory': [488], 'IFN-stimulated': [490, 3929], '(S)-5-[2-(1-phenylethylamino)pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-2-(4-piperidinyl)imidazole': [492], 'myxovirus-resistance': [493], 'gene-1': [494], 'peptidoglycan': [495], 'dsRNA-dependent': [496], 'toll-like': [505, 690], 'receptor': [506, 691, 770, 1855], 'glyceraldehyde-3-': [507], 'phosphate': [508], 'dehydrogenase': [509], 'mitogen-activated': [510], 'reverse': [512, 2852], 'Neutrophils': [514, 2475, 3033], 'play': [515, 941], 'vital': [517], 'role': [518, 943, 1148, 1383, 1575, 1621, 2269], 'innate': [521, 2273], 'immune': [522, 578], 'migrating': [525], 'sites': [527], 'infection,': [529], 'ingesting': [530], 'microorganisms,': [531], 'producing': [533], 'antimicrobial': [534, 593], 'agents.': [535], 'Activation': [536], 'can': [539, 4130], 'occur': [540], 'recognition': [542, 698], 'structural': [544], 'features': [545], 'microbes,': [547], 'including': [548, 1128, 1590], 'cell': [551, 584, 998, 1174, 1391, 1852, 2598, 2626, 3104, 3174, 4020], 'wall': [552], 'component': [553], '(LPS)1': [555], '(1Hoffmann': [556], 'J.A.': [557, 633, 1455, 1472, 1503, 1651, 2354], 'Kafatos': [558], 'F.C.': [559], 'Janeway': [560, 1110], 'C.A.': [561, 1112], 'Ezekowitz': [562], 'R.A.B.': [563], 'Science.': [564, 820, 2572], '1999;': [565, 846, 877, 924, 1038, 1069, 1086, 1494, 1673, 1808, 1836, 2467, 4191, 4241], '284:': [566, 2067, 3369], '1313-1318Crossref': [567], 'PubMed': [568, 647, 666, 729, 754, 787, 824, 854, 880, 906, 932, 958, 978, 1016, 1046, 1072, 1094, 1123, 1140, 1215, 1239, 1263, 1278, 1299, 1340, 1358, 1425, 1497, 1525, 1610, 1676, 1699, 1755, 1811, 1839, 1894, 1998, 2010, 2048, 2186, 2203, 2224, 2246, 2470, 2576, 2670, 2789, 2829, 2899, 3348, 3415, 3685, 3697, 3734, 3969, 4004, 4016, 4194, 4244, 4390], 'Scopus': [569, 648, 667, 730, 755, 788, 825, 855, 907, 933, 959, 979, 1017, 1047, 1095, 1124, 1216, 1240, 1300, 1341, 1359, 1426, 1498, 1526, 1611, 1677, 1700, 1756, 1812, 1840, 1895, 2049, 2187, 2204, 2225, 2471, 2577, 2671, 2790, 2830, 3349, 3416, 3735, 3970], '(2153)': [570], 'Google': [571, 650, 669, 732, 757, 790, 827, 857, 881, 909, 935, 961, 981, 1019, 1049, 1073, 1097, 1126, 1141, 1218, 1242, 1264, 1279, 1302, 1325, 1343, 1361, 1402, 1414, 1428, 1469, 1500, 1528, 1551, 1572, 1613, 1679, 1702, 1758, 1814, 1842, 1897, 1999, 2011, 2051, 2069, 2189, 2206, 2227, 2247, 2368, 2473, 2509, 2579, 2673, 2792, 2832, 2900, 3351, 3371, 3418, 3686, 3698, 3737, 3972, 4005, 4017, 4195, 4245], 'Scholar).': [572, 670, 758, 982, 1142, 1362, 1429, 1573, 1703, 1759, 1898, 2012, 2369, 2474, 2510, 2580, 2674, 2793, 2833, 3419, 3738, 3973, 4018, 4246], 'Exposure': [573, 4044, 4068], 'other': [577, 1158, 1173, 3383, 4354], 'primes': [582], 'respond': [586], 'secondary': [588], 'agonists': [589], 'secretion': [591], 'peptides': [594], 'formation': [596], 'superoxide.': [598], 'addition,': [600], 'it': [601, 4333], 'now': [603], 'recognized': [604], 'potent': [608], 'synthetic': [609], 'produce': [612], 'TNFα': [618], 'IL-1β,': [620, 3478], 'coded': [623], 'for': [624, 1715, 2618, 2630, 2800, 2884, 2943, 2985, 3017, 3039, 3101, 3114, 3122, 3136, 3207, 3212, 3226, 3234, 3324, 3481, 3496, 4024, 4049, 4073, 4116, 4207, 4269, 4283, 4362], 'theTNFA': [626], 'IL-1β': [628], '(2Scapini': [630], 'P.': [631, 815, 1101, 1459, 1791, 1819, 1821, 1990, 2358, 3677, 3996, 4382], 'Lapinet-Vera': [632], 'Gasperini': [634, 654], 'S.': [635, 655, 749, 844, 874, 886, 1036, 1066, 1084, 1109, 1294, 1564, 1984, 2219, 2447, 2769, 3410, 3671, 3718, 3990, 4189, 4239, 4376], 'Calzetti': [636], 'F.': [637, 639, 920, 1225, 1986, 3673, 3992, 4378], 'Bazzoni': [638], 'Cassatella': [640, 1134], 'M.A.': [641, 653, 1135, 1484, 1663, 4187, 4237], 'Immunol.': [642, 876, 974, 1068, 1211, 1321, 1465, 1521, 1547, 1568, 2364, 3730], 'Rev.': [643, 1750, 1889], '2000;': [644, 726, 784, 898, 1013, 1212, 1231, 1422, 1522, 1607], '177:': [645], '195-203Crossref': [646], '(621)': [649], 'Scholar,': [651, 733, 791, 828, 858, 882, 910, 962, 1020, 1050, 1074, 1219, 1243, 1265, 1280, 1303, 1326, 1344, 1403, 1415, 1470, 1501, 1529, 1552, 1815, 2000, 2052, 2190, 2207, 2228, 3687, 4006], '3Cassatella': [652], 'Russo': [656], 'M.P.': [657, 2173], 'Ann.': [658], 'N.': [659, 716, 774, 1003, 1197, 1203, 1328, 2002, 3689, 4008], 'Y.': [660, 870, 1062, 1787, 1827, 2232, 2459], 'Acad.': [661, 746, 1291, 2216, 3407], 'Sci.': [662, 747, 1292, 2217, 3408], '1997;': [663, 1137, 1275, 1399, 1411, 2221], '832:': [664], '233-242Crossref': [665], '(80)': [668], 'Production': [671], 'these': [673, 1364, 1626, 2148, 3430, 3881], 'immunomodulatory': [674], 'proteins': [675, 4104, 4133], 'controlled': [681], '(TLR)': [692], 'family': [693, 1368, 1437, 1772, 3978], 'implicated': [695], 'bacteria': [700], 'activation': [704, 990, 1178, 1386, 1768, 1944, 3388, 4215], 'cellular': [706, 1385, 1705], 'important': [709], 'host': [711], 'defense': [712], '(4Muzio': [713, 771, 1000], 'M.': [714, 772, 809, 813, 894, 951, 1001, 1201, 1407, 1793, 1829, 2004, 2443, 2453, 3691, 4010, 4135, 4179, 4183, 4209, 4229, 4233], 'Polentarutti': [715, 773, 1002], 'Bosisio': [717, 775, 1004], 'D.': [718, 776, 805, 972, 1005, 1539, 1556], 'Prahladen': [719, 777, 1006], 'M.K.P.': [720, 778, 1007], 'Mantovani': [721, 779, 1008], 'A.': [722, 750, 780, 793, 1009, 1105, 1133, 1295, 1394, 1405, 1535, 1988, 2220, 2421, 2457, 2657, 3400, 3411, 3471, 3675, 3994, 4177, 4181, 4227, 4231, 4380], 'J.': [723, 781, 875, 895, 921, 952, 973, 1010, 1067, 1228, 1254, 1282, 1320, 1336, 1354, 1396, 1419, 1464, 1491, 1520, 1533, 1546, 1567, 1604, 1670, 1688, 1805, 1817, 1832, 1993, 2037, 2064, 2180, 2198, 2237, 2363, 2445, 2455, 2464, 2504, 2664, 2778, 2818, 2895, 3337, 3366, 3680, 3722, 3958, 3999, 4385], 'Leukocyte': [724, 782, 1011, 2181], 'Biol.': [725, 783, 896, 922, 1012, 1229, 1255, 1274, 1689, 2038, 2182, 2238, 2779, 2819, 3338, 3959, 4144], '67:': [727, 785, 1014, 1753, 1892], '450-456Crossref': [728, 786, 1015], '(155)': [731, 789, 1018], '5Rock': [734], 'F.L.': [735], 'Hardiman': [736], 'G.': [737, 4185, 4235], 'Timans': [738], 'J.C.': [739, 912, 1227, 2175, 2567], 'Kastelein': [740], 'R.A.': [741], 'Bazan': [742], 'J.F.': [743], 'Proc.': [744, 1289, 2214, 3405], 'Natl.': [745, 1290, 2215, 3406], 'U.': [748, 1293, 2218, 3409], '1998;': [751, 821, 955, 1115, 1322, 1548, 1569, 1752, 1891, 2667, 2896, 3412], '95:': [752, 3413], '588-593Crossref': [753], '(1451)': [756], 'Genetic': [759], 'biochemical': [761], 'suggest': [763, 2265, 2281], 'major': [768, 1382, 1900], '6Poltorak': [792], 'He': [794], 'X.': [795, 803], 'Smirnova': [796], 'I.': [797, 2889], 'Liu': [798], 'M.Y.': [799], 'Huffel': [800], 'C.V.': [801], 'Du': [802], 'Birdwell': [804], 'Alejos': [806], 'E.': [807, 1103, 1558, 2296], 'Silva': [808], 'Galanos': [810], 'C.': [811, 1107, 1789, 1797, 1799, 1825, 1992, 2494, 3679, 3998, 4139, 4384], 'Freudenberg': [812], 'Ricciardi-Castagnoli': [814], 'Layton': [816], 'B.': [817, 819, 2435, 2980], 'Beutler': [818], '282:': [822], '2085-2088Crossref': [823], '(6450)': [826], '7Takeuchi': [829, 1021], 'O.': [830, 862, 1022, 1054, 1078], 'Hoshino': [831, 1023], 'K.': [832, 842, 860, 872, 884, 892, 968, 1024, 1034, 1052, 1064, 1082, 1249, 1417, 1602, 2429, 2765, 3714], 'Kawai': [833, 863, 1025, 1055], 'T.': [834, 840, 864, 868, 890, 949, 1026, 1032, 1056, 1060, 1076, 1080, 2213, 3953], 'Sanjo': [835, 865, 1027, 1057], 'H.': [836, 838, 866, 947, 1028, 1030, 1058, 1221, 1801, 1823, 2209], 'Takada': [837, 1029], 'Ogawa': [839, 867, 1031, 1059, 1079], 'Takeda': [841, 869, 871, 1033, 1061, 1063, 1081], 'Akira': [843, 873, 1035, 1065, 1083], 'Immunity.': [845, 1037, 1085], '11:': [847, 1039, 1087], '443-451Abstract': [848, 1040], 'Full': [849, 851, 901, 903, 927, 929, 1041, 1043, 1089, 1091, 1118, 1120, 1234, 1236, 1260, 1694, 1696, 2043, 2045, 2243, 2784, 2786, 2824, 2826, 3343, 3345, 3964, 3966], 'Text': [850, 852, 902, 904, 928, 930, 1042, 1044, 1090, 1092, 1119, 1121, 1235, 1237, 1261, 1695, 1697, 2044, 2046, 2244, 2785, 2787, 2825, 2827, 3344, 3346, 3965, 3967], 'PDF': [853, 905, 931, 1045, 1093, 1122, 1238, 1262, 1698, 2047, 2245, 2788, 2828, 3347, 3968], '(2789)': [856, 1048], '8Hoshino': [859, 1051], 'Takeuchi': [861, 1053], '162:': [878, 1070], '3749-3752Crossref': [879, 1071], '9Kawasaki': [883], 'Akashi': [885], 'Shimazu': [887], 'R.': [888, 964, 1099, 1560, 1803, 1831], 'Yoshida': [889], 'Miyake': [891, 967], 'Nishijima': [893], 'Chem.': [897, 923, 1230, 1256, 1690, 2039, 2239, 2466, 2780, 2820, 3339, 3960], '275:': [899, 1232], '2251-2254Abstract': [900], '(306)': [908], '10Chow': [911], 'Young': [913, 1222, 1475, 1504, 1654], 'D.W.': [914, 1223], 'Golenbock': [915], 'D.T.': [916], 'Christ': [917], 'W.J.': [918], 'Gusovsky': [919, 1224], '274:': [925], '10689-10692Abstract': [926], '(1617)': [934], 'Scholar),': [936, 1127, 1614, 1843, 2248, 2901, 3699, 4149], 'TLR2': [938], 'may': [939, 1161, 3703], 'also': [940, 1162, 4220], '(11Kirschning': [944], 'C.J.': [945, 970, 2451], 'Wesche': [946], 'Merrill-Ayres': [948], 'Rothe': [950], 'Exp.': [953], 'Med.': [954, 2465], '188:': [956], '2091-2097Crossref': [957], '(655)': [960], '12Dziarski': [963], 'Wang': [965], 'Q.': [966], 'Kirschning': [969], 'Gupta': [971], '2001;': [975, 4146], '166:': [976], '1938-1944Crossref': [977], '(181)': [980], 'stimulates': [984], 'pathway': [986], 'leading': [987, 1864], 'regulator': [994], 'NFκB': [995, 1144], 'many': [997, 1172], 'types': [999, 1392, 4356], '13Kawai': [1075], 'Adachi': [1077], '115-122Abstract': [1088], '(1728)': [1096], 'Scholar,14Medzhitov': [1098], 'Preston-Hurlburt': [1100], 'Kopp': [1102], 'Stadlen': [1104], 'Chen': [1106], 'Ghosh': [1108], 'Jr.,': [1111, 3950], 'Mol.': [1113, 1272, 4143], 'Cell.': [1114, 1273, 1420, 1605, 4142], '2:': [1116], '253-258Abstract': [1117], '(1304)': [1125], '(15McDonald': [1130], 'P.P.': [1131, 1480, 1659], 'Bald': [1132], 'Blood.': [1136, 4190, 4240], '89:': [1138], '3421-3422Crossref': [1139], 'Whereas': [1143, 2157], 'plays': [1145, 1380], 'pivotal': [1147], 'regulating': [1150], 'cytokine': [1154, 1646, 3802], 'chemokine': [1156], 'genes,': [1157], 'regulators': [1160, 1775, 3981], 'be': [1163, 3486], 'involved': [1164, 1903], 'TLRs.': [1168], 'types,': [1175], 'poorly': [1180, 1845], 'understood': [1181, 1846], 'neutrophils.': [1183, 2077, 3768, 4043, 4322], 'tyrosine': [1186, 1862, 3988], 'serine/threonine': [1188, 1370], 'kinases': [1189, 1371, 1863], '(16Arbibe': [1192], 'L.': [1193, 1199, 1286, 2427], 'Mira': [1194], 'J.P.': [1195, 2211, 2423], 'Teusch': [1196], 'Kline': [1198], 'Guha': [1200], 'Mackman': [1202], 'Godowski': [1204], 'P.J.': [1205], 'Ulevitch': [1206, 2570], 'R.J.': [1207, 2571], 'Knaus': [1208], 'U.G.': [1209], 'Nat.': [1210, 3729], '1:': [1213], '533-540Crossref': [1214], '(568)': [1217], '17Yang': [1220], 'Chow': [1226], '20861-20866Abstract': [1233], '(243)': [1241], '18Weinstein': [1244], 'S.L.': [1245, 1253, 1284, 2425], 'Sanghera': [1246], 'J.S.': [1247], 'Lemke': [1248], 'DeFranco': [1250, 1287], 'A.L.': [1251, 1288], 'Pelech': [1252], '1992;': [1257, 2200], '267:': [1258], '14955-14962Abstract': [1259], '19Swantek': [1266], 'J.L.': [1267], 'Cobb': [1268], 'M.H.': [1269], 'Geppert': [1270], 'T.D.': [1271], '17:': [1276, 2897], '6274-6282Crossref': [1277], '20Hambleton': [1281], 'Weinstein': [1283], 'Lem': [1285], '1996;': [1296, 1337, 1466, 2365], '93:': [1297, 4192, 4242], '2774-2778Crossref': [1298], '(414)': [1301], '21Scherle': [1304], 'P.A.': [1305, 1554], 'Jones': [1306, 2059, 3361, 3709], 'E.A.': [1307, 2449], 'Favata': [1308], 'M.F.': [1309], 'Daulerio': [1310], 'A.J.': [1311, 2431, 4137], 'Covington': [1312], 'M.B.': [1313, 1681, 2030, 2811, 3330], 'Nurnberg': [1314], 'S.A.': [1315], 'Magolda': [1316], 'R.L.': [1317], 'Trzaskos': [1318], 'J.M.': [1319, 4141], '161:': [1323, 1570], '5681-5686PubMed': [1324], '22Nahas': [1327], 'Molski': [1329, 1347], 'T.F.': [1330, 1348], 'Fernandez': [1331, 1536], 'G.A.': [1332, 1537, 2196], "Sha'afi": [1333, 1351, 1544], 'R.I.': [1334, 1352, 1545], 'Biochem.': [1335, 1353, 1398, 1751, 1890, 2199], '318:': [1338], '247-253Crossref': [1339], '(121)': [1342], '23Fouda': [1345], 'S.I.': [1346], 'Ashour': [1349], 'M.S.': [1350, 1515], '1995;': [1355, 3961], '308:': [1356], '815-822Crossref': [1357], '(51)': [1360], 'Among': [1363], 'MAP': [1366, 1373, 1435], '(p42/p44': [1372], 'kinase,': [1374, 1377], 'c-Jun': [1375], 'N-terminal': [1376], 'p38)': [1379], 'variety': [1389], '(24Brunet': [1393], 'Pouyssegur': [1395], 'Essays': [1397], '32:': [1400], '1-16PubMed': [1401], '25Minden': [1404], 'Karin': [1406], 'Biochim.': [1408], 'Biophys.': [1409], 'Acta.': [1410], '1333:': [1412], 'F85-F104PubMed': [1413], '26Ono': [1416], 'Han': [1418, 1603], 'Signal.': [1421, 1606], '12:': [1423, 1608], '1-13Crossref': [1424, 1609, 1838], '(1393)': [1427, 1612], 'predominantly': [1439], 'regulates': [1446, 4203], 'translation': [1448], 'cytokines,': [1450], 'adhesion,': [1451], 'migration': [1453], '(27Nick': [1454, 2353], 'Avdi': [1456, 1473, 1508, 1652, 2355], 'N.J.': [1457, 1474, 1509, 1653, 2356, 2403], 'Gerwins': [1458, 2357], 'Johnson': [1460, 1487, 1666, 2359], 'G.L.': [1461, 1488, 1667, 2360], 'Worthen': [1462, 1489, 1518, 1668, 1686, 2035, 2061, 2361, 2766, 2816, 3335, 3363], 'G.S.': [1463, 1490, 1519, 1669, 1687, 2036, 2062, 2362, 2767, 2817, 3336, 3364], '156:': [1467, 2366], '4867-4875PubMed': [1468, 2367], '28Nick': [1471], 'S.K.': [1476, 1505, 1655, 3948], 'Lehman': [1477, 1656], 'L.A.': [1478, 1657, 2496], 'McDonald': [1479, 1658], 'Frasch': [1481, 1660], 'S.C.': [1482, 1661], 'Billstrom': [1483, 1662], 'Henson': [1485, 1516, 1664, 2501, 2662, 2776], 'P.M.': [1486, 1517, 1665, 2194, 2236, 2502, 2663, 2777], 'Clin.': [1492, 1671, 2665], 'Invest.': [1493, 1672, 2666], '103:': [1495, 1674], '851-858Crossref': [1496, 1675], '(264)': [1499, 1678], '29Nick': [1502], 'Brown': [1506], 'K.K.': [1507], 'Arndt': [1510, 2055, 3357], 'P.G.': [1511, 2056, 3358], 'Suratt': [1512], 'B.T.': [1513], 'Janes': [1514], '164:': [1523], '2151-2159Crossref': [1524], '(229)': [1527], '30Zu': [1530], 'Y.L.': [1531], 'Qi': [1532], 'Gilchrist': [1534], 'Vazquez-Abad': [1538], 'Kreutzer': [1540], 'D.L.': [1541, 2655, 2775], 'Huang': [1542], 'C.K.': [1543], '160:': [1549], '1982-1989PubMed': [1550], '31Detmers': [1553], 'Zhou': [1555, 3399], 'Polizzi': [1557], 'Thieringer': [1559], 'Hanlon': [1561, 2436], 'W.A.': [1562, 2437], 'Vaidya': [1563], 'Bansal': [1565], 'V.': [1566, 3708], '1921-1929PubMed': [1571], 'regulation': [1579, 2072], 'less': [1584, 2516], 'well': [1585, 1981, 2704, 3004], 'understood,': [1586], 'factors,': [1589], 'activating': [1591, 1625], 'factor-2,': [1593], 'SRF': [1594], 'accessory': [1595], 'protein-1,': [1596], 'CCAAT-enhancer': [1598], 'binding': [1599], 'protein-β': [1600], '(26Ono': [1601], 'known': [1616, 1929, 3484, 3620, 3744], 'substrates': [1617], 'has': [1631, 1979, 2169], 'been': [1633, 1968, 1980, 2170], 'explored.': [1634], 'inhibitors': [1636, 2144], 'have': [1639, 1967, 4313], 'little': [1640, 3537, 3627], 'effect': [1641], '(28Nick': [1650], 'Scholar,32Fessler': [1680], 'Malcolm': [1682, 2031, 2764, 2812, 3331], 'K.C.': [1683, 2032, 2054, 2179, 2813, 3332, 3356], 'Duncan': [1684, 2033, 2814, 3333], 'M.W.': [1685, 2034, 2815, 3334], '2002;': [1691, 2040, 2781, 2821, 3340, 3731], '277:': [1692, 2041, 2782, 2822, 3341], '31291-31302Abstract': [1693, 2042, 2823, 3342], '(158)': [1701, 2050, 2831, 3350], 'viral': [1708], 'infection': [1709], 'includes': [1710], 'interferons,': [1719, 3393], 'IFNα': [1720, 2915, 3394, 3615, 3625, 3863, 4091], 'IFNβ,': [1722], 'act': [1724], 'an': [1726, 2277, 3213, 3235, 3567, 3649, 4337], 'autocrine': [1727], 'or': [1728, 2097, 2108, 2634, 2744, 2866, 2939, 2951, 2973, 2990, 3181, 3395, 3765, 4063], 'paracrine': [1729, 4357], 'manner': [1730], 'stimulate': [1732, 3746], 'interferon-stimulated': [1736, 1932], '(ISGs)': [1738], '(33Stark': [1739, 1878], 'G.R.': [1740, 1879, 2419, 3955], 'Kerr': [1741, 1880], 'I.M.': [1742, 1881], 'Williams': [1743, 1882, 3401, 3719], 'B.R.G.': [1744, 1883, 3402], 'Silverman': [1745, 1884, 3403], 'R.H.': [1746, 1885, 3404], 'Schreiber': [1747, 1886], 'R.D.': [1748, 1887], 'Annu.': [1749, 1888], '227-264Crossref': [1754, 1893], '(3380)': [1757, 1896], 'Induction': [1760, 3523], 'IFNα/β': [1762, 1848, 1905, 1953, 3840, 3974], 'virus': [1765, 2168], 'requires': [1766], 'IRF': [1771], 'phosphorylation,': [1777], 'subsequent': [1779, 1876], 'IFNA': [1783, 2887, 3764], '(34Mamane': [1786], 'Heylbroeck': [1788, 1824], 'Genin': [1790, 1820], 'Algarte': [1792, 1828], 'Servant': [1794], 'M.J.': [1795, 3716, 3726], 'LePage': [1796], 'DeLuca': [1798], 'Kwon': [1800], 'Lin': [1802, 1830, 2444], 'Hiscott': [1804], 'Gene': [1806], '(Amst.).': [1807], '237:': [1809], '1-14Crossref': [1810], '(464)': [1813], '35Hiscott': [1816], 'Pitha': [1818, 2235], 'Nguyen': [1822, 2412], 'Mamane': [1826], 'Interferon': [1833], 'Cytokine': [1834], 'Res.': [1835], '19:': [1837], '(196)': [1841], 'through': [1844, 3749], 'pathways.': [1847], 'binds': [1849, 1917], 'surface': [1853], 'IFN': [1854, 3846, 3856], 'Jak1': [1859], 'Tyk2': [1861], 'phosphorylation': [1867, 3984, 4083, 4100], 'STAT1': [1870, 4029, 4124], 'STAT2': [1872], 'dimerization': [1877], 'regulatory': [1901], 'action,': [1906], 'ISGF3,': [1907], 'complex': [1910], 'STAT1,': [1912, 4025], 'STAT2,': [1913], 'IRF9-p48-ISGF3γ.': [1915], 'ISGF3': [1916], 'conserved': [1920], 'sequence': [1921], '3′': [1924], 'region': [1925], 'IFN-responsive': [1927], 'element.': [1934], 'ISGs,': [1935, 2107, 3506], 'MX1,': [1938, 2885, 3623, 4289], 'primarily': [1941], 'element,': [1947], 'activity': [1951, 1966, 3245], 'resides': [1954], 'their': [1956], 'ability': [1957], 'ISGs.': [1960], 'Links': [1961], 'between': [1962], 'anti-bacterial': [1963], 'suggested': [1969, 3927], 'previously.': [1970], 'particular,': [1972], 'IFNβ': [1976, 2917, 3396, 3865, 4368], 'described': [1982, 2028, 2171, 2351, 2491, 2761, 2809, 3031], '(36Gessani': [1983, 3670, 3989, 4375], 'Belardelli': [1985, 3672, 3991, 4377], 'Pecorelli': [1987, 3674, 3993, 4379], 'Puddu': [1989, 3676, 3995, 4381], 'Baglioni': [1991, 3678, 3997, 4383], 'Virol.': [1994, 3681, 4000, 4386], '1989;': [1995, 3682, 4001, 4387], '63:': [1996, 3683, 4002, 4388], '2785-2789Crossref': [1997, 3684, 4003, 4389], '37Maehara': [2001, 3688, 4007], 'Ho': [2003, 3690, 4009], 'Infect.': [2005, 3692, 4011], 'Immun.': [2006, 3693, 4012], '1977;': [2007, 3694, 4013], '15:': [2008, 3695, 4014], '78-83Crossref': [2009, 3696, 4015], 'way,': [2015], 'accomplished': [2020], 'infection.': [2025], 'recently': [2027, 3312], '(32Fessler': [2029, 2810, 3329], '38Malcolm': [2053], 'Manos': [2057, 3359], 'E.J.': [2058, 3360], 'D.A.': [2060, 2409, 3362], 'Am.': [2063, 2503, 3365], 'Physiol.': [2065, 3367], '2003;': [2066, 3368], 'L663-L670PubMed': [2068, 3370], 'Scholar)': [2070, 3352, 3372, 4196], 'ISGs': [2074, 2087, 2132, 2164, 3431, 3747, 3887], 'LPS-treated': [2076, 3915], 'Here': [2078], 'investigated': [2080, 4151], 'mechanisms': [2082], 'LPS.': [2091, 2262, 3548, 3861], 'increaseIFNA': [2096], 'mediator': [2104], 'STAT': [2110, 2126, 3977, 4087, 4103, 4132], 'proteins;': [2111], 'increase': [2116, 4057], 'ISG-inducing': [2122, 4338], 'factor(s),': [2123], 'proteins.': [2127, 4088], 'macrophages,': [2140, 4367], 'sensitive': [2142], 'p38,': [2146], 'effects': [2149], 'IFN-dependent': [2159], '-independent': [2161], 'dsRNA': [2166, 3940], '(39Hayes': [2172], 'Enterline': [2174], 'Gerrard': [2176], 'T.L.': [2177], 'Zoon': [2178], '1991;': [2183], '50:': [2184], '176-181Crossref': [2185], '(40)': [2188], '40Wathelet': [2191], 'M.G.': [2192], 'Berr': [2193], 'Huez': [2195], 'Eur.': [2197], '206:': [2201], '901-910Crossref': [2202], '(82)': [2205], '41Zhu': [2208], 'Cong': [2210], 'Shenk': [2212], '94:': [2222], '13985-13990Crossref': [2223], '(263)': [2226], '42Au': [2229], 'W.C.': [2230], 'Su': [2231], 'Raj': [2233], 'B.K.': [2234], '1993;': [2240], '268:': [2241], '24032-24040Abstract': [2242], 'our': [2250, 3740], 'knowledge': [2251, 3741], 'first': [2255], 'report': [2256], 'IFN-independent': [2258], 'ISG': [2259, 3438, 3448, 3604, 4165, 4373], 'These': [2263, 4340], 'potential': [2267], 'new': [2268], 'immunity': [2274], 'inducing': [2276], 'genotype': [2279], 'distinct': [2283], 'coli': [2297], 'strain': [2298], '0111:B4': [2299], 'purchased': [2301, 2372], 'List': [2303], 'Biological': [2304], 'Laboratories': [2305], 'contained': [2307], 'minimal': [2308], 'contamination': [2310], 'determined': [2312, 3247, 3532], 'silver': [2314], 'staining.': [2315], 'Peptidoglycan': [2316], '(Fluka)': [2317], 'prepared': [2319, 2645, 2850], 'extensive': [2321], 'sonication': [2322], 'followed': [2323], 'centrifugation.': [2325], 'Anti-STAT1': [2326], '-STAT3': [2328], 'were': [2329, 2341, 2385, 2393, 2476, 2524, 2594, 2601, 2628, 2644, 2683, 2705, 2716, 2723, 2741, 2758, 2835, 2846, 2879, 2906, 2935, 2960, 2983, 3015, 3024, 3037, 3106, 3144, 3160, 3189, 3222, 3241, 3277, 3379, 3516, 3609, 3812, 3866, 4022, 4037, 4267, 4278], 'obtained': [2330, 2386, 2595, 2751], 'Transduction': [2332], 'Laboratories,': [2333], 'anti-phospho-STAT1': [2335], '(Tyr-701),': [2336], 'phospho-STAT3': [2337, 4064], '(Tyr-705),': [2338], 'phospho-p38': [2340], 'Cell': [2343], 'Signaling.': [2344], 'Anti-p38': [2345], 'polyclonal': [2346], 'antiserum': [2347], 'produced': [2349, 3913], 'IFNαA/D': [2370], 'PBL': [2374], 'Biomedical': [2375], 'Laboratories.': [2376], 'Cycloheximide,': [2377], 'lipoteichoic': [2378], 'acid': [2379], '(fromStaphylococcus': [2380], 'aureus),': [2381], 'polymyxin': [2383, 2979, 2996, 3647], 'B': [2384], 'Sigma.': [2388], 'SB203580,': [2389], 'SB202474,': [2390], 'PD98059': [2392], 'Calbiochem.': [2395], '(S)-5-[2-(1-Phenylethylamino)pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-2-': [2396], '(4-piperidinyl)imidazole': [2397], '(M39)': [2398], 'Merck': [2401], '(43Liverton': [2402], 'Butcher': [2404], 'J.W.': [2405], 'Claiborne': [2406], 'C.F.': [2407, 2439], 'Claremon': [2408], 'Libby': [2410], 'B.E.': [2411], 'K.T.': [2413], 'Pitzenberger': [2414], 'S.M.': [2415], 'Selnick': [2416], 'H.G.': [2417], 'Smith': [2418], 'Tebben': [2420], 'Vacca': [2422], 'Varga': [2424], 'Agarwal': [2426], 'Dancheck': [2428], 'Forsyth': [2430], 'Fletcher': [2432], 'D.S.': [2433], 'Frantz': [2434], 'Harper': [2438], 'Hofsess': [2440], 'S.J.': [2441, 2463], 'Kostura': [2442], 'Luell': [2446], "O'Neill": [2448], 'Oreville': [2450], 'Pang': [2452], 'Parsons': [2454], 'Rolando': [2456], 'Sahly': [2458], 'Visco': [2460], 'D.M.': [2461], "O'Keefe": [2462], '42:': [2468], '2180-2190Crossref': [2469], '(207)': [2472, 2791], 'isolated': [2477, 2936], 'citrated': [2479], 'blood': [2480], 'healthy': [2482, 2680], 'donors': [2483, 2845], 'purified': [2485], 'Percoll': [2488], 'gradient,': [2489], '(44Haslett': [2493], 'Guthrie': [2495], 'Kopaniak': [2497], 'M.M.': [2498], 'Johnston': [2499], 'R.B.J.': [2500], 'Pathol.': [2505], '1985;': [2506], '119:': [2507], '101-110PubMed': [2508], 'Contamination': [2511], 'monocytic': [2513, 2677], 'than': [2517], '5%.': [2518], 'Cells': [2519, 2600, 3014, 3827], '(20–25': [2520], '×': [2521, 2585, 2696, 2863, 2958, 3035, 3134, 3186], '106': [2522, 2586, 2697, 2864, 3187], 'cells/ml)': [2523], 'resuspended': [2525, 3052], 'neutrophil': [2527, 2966], '(RPMI': [2529], 'containing': [2530], '1%': [2531, 3195], 'heat-inactivated': [2532, 2728], 'platelet-poor': [2533, 2547], 'plasma': [2534, 2548], '10': [2536, 2977, 2994, 3071, 3074, 3088, 3115, 3208, 3215, 3257, 3272], 'mm': [2537, 3058, 3063, 3066, 3069, 3081, 3085, 3089, 3120, 3200, 3253, 3258, 3269, 3273], 'HEPES,': [2538], 'pH': [2539, 3049, 3060, 3202, 3255], '7.6)': [2540], 'divided': [2542], 'into': [2543], '1.5-ml': [2544], 'tubes.': [2545], 'Heat-inactivated': [2546], 'necessary': [2551], 'source': [2552], 'LPS-binding': [2554], '(45Schumann': [2556], 'R.R.': [2557], 'Leong': [2558], 'S.R.': [2559], 'Flaggs': [2560], 'G.W.': [2561], 'Gray': [2562], 'P.W.': [2563, 2659], 'Wright': [2564], 'S.D.': [2565, 3398], 'Mathison': [2566], 'Tobias': [2568], 'P.S.': [2569], '1990;': [2573], '249:': [2574], '1429-1431Crossref': [2575], '(1379)': [2578], 'RT-PCR': [2581, 2592, 3027, 3519, 3772], 'analysis': [2582, 2801, 3421, 3773, 3823], 'utilized': [2583], '20': [2584, 2862, 3057, 3123, 3137, 3185, 3252, 3280], '(in': [2588], '1': [2589, 3077, 3080, 3227, 3268, 3470, 3500, 3521, 3578, 3596, 3599, 3617, 3633], 'ml).': [2590], 'Similar': [2591], 'results': [2593], 'lower': [2597], 'concentrations.': [2599], 'treated': [2602, 2875, 3145, 3321], 'indicated': [2605, 3041, 3171, 3435, 3774, 4200], 'concentration': [2606], 'IFNα/D,': [2609], 'PGN': [2611], 'rotated': [2613, 3025], 'continuously': [2614], '37': [2616, 3021], '°C': [2617, 3250], 'up': [2619], '4': [2621, 2944, 2986, 3018, 3126, 3140, 3325, 3453, 3497, 3545, 3572, 4053, 4117, 4284], 'h.': [2622], 'some': [2624], 'experiments,': [2625], 'supernatants': [2627, 3218, 3871, 4272], 'retained': [2629], 'conditioned': [2631, 4325], 'media': [2632], 'experiments': [2633, 2740, 2909], 'enzyme-linked': [2635, 2921], 'immunosorbent': [2636, 2922], 'assay': [2637, 2923], '(see': [2638], 'below).': [2639], 'Human': [2640], 'monocyte': [2641], 'derived': [2642, 2860], 'method': [2648], 'Fadoket': [2650], 'al.': [2651], '(46Fadok': [2652], 'V.A.': [2653, 2773], 'Bratton': [2654, 2774], 'Konowal': [2656], 'Freed': [2658], 'Westcott': [2660], 'J.Y.': [2661], '101:': [2668], '890-898Crossref': [2669], '(2562)': [2672], 'Briefly,': [2675], 'peripheral': [2676], 'volunteers': [2682], 'washed': [2684, 3043, 3148], "Hanks'": [2686], 'balanced': [2687], 'salt': [2688], 'solution': [2689], 'calcium': [2691], 'magnesium,': [2693], '12': [2695], 'X-vivo': [2700], '(BioWhittaker)': [2702], 'per': [2703, 3003], 'seeded': [2706], '6-well': [2708, 3012], 'plates.': [2709], 'One': [2710], 'hour': [2711], 'after': [2712, 2747, 3279, 3294, 3441, 3539, 3547, 3560], 'plating,': [2713], 'non-adherent': [2714], 'removed': [2717], 'washing,': [2719], 'adherent': [2721], 'grown': [2724], 'X-vivo,': [2726], '10%': [2727], 'serum.': [2730], 'changed': [2734], 'every': [2735], '3': [2736], 'days': [2737, 2746], 'thereafter,': [2738], 'performed': [2742, 2807, 2880, 3029, 3306], '7': [2743], '8': [2745], 'plating.': [2748], 'RAW264.7': [2749, 2911], 'cells,': [2750], 'American': [2754], 'Type': [2755], 'Culture': [2756], 'Collection,': [2757], 'cultured': [2759, 3009], '(47Xiao': [2762], 'Y.Q.': [2763], 'Gardai': [2768], 'Schiemann': [2770], 'W.P.': [2771], 'Fadok': [2772], '14884-14893Abstract': [2783], 'Preparation': [2794], 'total': [2796, 2858], '(5': [2798], 'μg)': [2799], 'oligonucleotide': [2803, 3328, 3433, 3534], 'array': [2804, 3434], '(Affymetrix)': [2805], 'Data': [2834], 'analyzed': [2836], 'using': [2837, 2854, 2881, 3108, 3307, 3327], 'Affymetrix': [2838], 'GeneChip': [2839], 'software.': [2840], 'Time': [2841], 'courses': [2842], 'three': [2844, 3463], 'analyzed.': [2847], 'cDNA': [2848, 3354], '2': [2855, 3084, 3264, 3540, 3804, 4106], 'μg': [2856, 2868, 3183, 3265], 'RNA,': [2859], '0.5–2': [2867], 'indicated.': [2877], 'PCRs': [2878], 'specific': [2882], 'primers': [2883, 2905], 'PKR,TNFA,': [2886], '(48Marie': [2888], 'Durbin': [2890], 'J.E.': [2891], 'Levy': [2892], 'D.E.': [2893], 'EMBO': [2894], '6660-6669Crossref': [2898], 'IFNB,': [2902], 'andGAPDH.': [2903], 'Murine-specific': [2904], 'used': [2907], 'cells.': [2912], 'Secretion': [2913], 'quantified': [2919], 'kits': [2924], 'directed': [2926], 'manufacturer': [2929], '(R': [2930], '&': [2931], 'D': [2932], 'Systems).': [2933], 'Supernatants': [2934], 'h': [2945, 2987, 3019, 3326, 3454, 3498, 3541, 3546, 3573, 4054, 4118], '100': [2947], 'ng/ml': [2948, 3597], '(LPS-CM)': [2950], 'non-stimulated': [2952], '(NS-CM).': [2954], 'Naive': [2955], '(20': [2957, 3034], '106)': [2959, 3036], 'suspended': [2961], '250': [2963, 3062], 'μl': [2964, 2970, 3055, 3180, 3193], '750': [2969, 3192], 'NS-CM': [2972, 2989], 'LPS-CM': [2974, 2991], 'supplemented': [2975, 2992, 3190], 'μg/ml': [2978, 2995, 3072, 3075], 'Monocyte-derived': [2981, 3142], 'B,': [2997, 3648], '1.5': [2999], 'ml': [3000], 'added': [3002, 3233, 4279], 'naive': [3006, 4281], 'plate.': [3013], 'incubated': [3016, 3204, 3223], '°C;': [3022], 'continuously.': [3026], 'above.': [3032], 'time,': [3042], 'once': [3044], 'ice-cold': [3046], 'phosphate-buffered': [3047, 3150], 'saline,': [3048, 3151], '7.4,': [3050, 3061, 3203, 3256], '400': [3054, 3119], 'imidazole,': [3059], 'sucrose,': [3064], '2.5': [3065], 'MgCl2,': [3067, 3259], '5': [3068, 3102], 'EGTA,': [3070], 'leupeptin,': [3073], 'aprotinin,': [3076], 'μm': [3078, 3094], 'pepstatin,': [3079], 'phenylmethylsulfonyl': [3082], 'fluoride,': [3083], 'p-nitrophenyl': [3086, 3274], 'phosphate,': [3087, 3091], 'β-glycerol': [3090], '200': [3093, 3111], 'sodium': [3095], 'orthovanadate.': [3096], 'After': [3097, 3787], 'incubation': [3098], 'ice': [3100, 3206], 'min,': [3103, 3209], 'suspensions': [3105], 'sonicated': [3107], 'Braun-Sonic': [3110], 'sonicator': [3112], 'twice': [3113], 's,': [3116], 'extracted': [3117], 'NaCl': [3121], 'min': [3124, 3138, 3281, 3559, 4051, 4075], '°C,': [3127], 'clarified': [3129], 'centrifugation': [3131], '18,000': [3133], 'g': [3135], '°C.': [3141], 'indicated,': [3147], 'lysed': [3153], 'SDS': [3155, 3286], 'sample': [3156, 3287], 'buffer.': [3157, 3288], 'Protein': [3158], 'samples': [3159], 'separated': [3161], 'SDS-PAGE,': [3163], 'transferred': [3164], 'nitrocellulose,': [3166], 'probed': [3168, 4023], 'antibody.': [3172], 'Whole': [3173, 4019], 'extracts': [3175, 4021], '(250': [3179], '400–500': [3182], 'cells)': [3188], 'Triton': [3196], 'X-100': [3197], '50': [3199, 3260], 'Tris,': [3201, 3254], 'centrifuged': [3211], 'additional': [3214, 3236], 'min.': [3216, 3238], 'spin': [3221], 'anti-p38': [3225], 'h,': [3228, 4285], 'A-Sepharose': [3231], '30': [3237, 3249, 3558, 4050, 4074], 'beads': [3240], 'washed,': [3242], 'μm[γ-32P]ATP': [3261], '(4': [3262], 'μCi/assay),': [3263], 'GST-ATF-2,': [3267], 'dithiothreitol,': [3270], 'phosphate.': [3275], 'Reactions': [3276], 'stopped': [3278], 'addition': [3283], '2×': [3285], 'Phosphorylation': [3289], 'ATF-2': [3291], 'visualized': [3293], 'SDS-PAGE': [3295], 'STORM': [3298], '860': [3299], 'PhosphorImager': [3300], '(Amersham': [3301, 3309], 'Biosciences),': [3302], 'quantification': [3304], 'ImageQuant': [3308], 'Biosciences).': [3310], 'demonstrated': [3313, 3660], 'changes': [3314], '(38Malcolm': [3355], 'microarray': [3373], 'analysis.': [3374], 'Unexpectedly,': [3375], 'increases': [3376], 'observed': [3380, 3451, 3589, 4078], 'systems': [3384], 'associated': [3386, 4213], '(49Der': [3397], '15623-15628Crossref': [3414], '(1537)': [3417], 'Further': [3420], 'time': [3424], 'course': [3425], 'levels': [3428, 3503, 3631, 3782], 'LPS-induced': [3437], 'occurred': [3440], 'prolonged': [3443], 'lag': [3444], '(Fig.1': [3445], 'A).': [3446, 3786, 3805], 'Little': [3447], 'until': [3452], 'stimulation;': [3457], 'examples': [3458], 'shown': [3467], 'Fig.': [3469], 'TNFA': [3476, 3513, 3551, 3585, 3630, 4303], 'NFκB-regulated': [3479], 'proinflammatory': [3482], 'increased': [3491], 'rapidly': [3492], 'sustained': [3495], '(Fig.': [3499, 3520, 3577, 3598, 3616, 3632, 3803, 4105], 'B).': [3501, 4067, 4107], 'Expression': [3502], 'two': [3505], 'PKR,': [3509], 'those': [3511, 3612], 'GAPDH': [3515, 4292], 'confirmed': [3517], 'C).': [3522, 3579, 4311], 'PKRparalleled': [3527], 'level': [3529, 3569, 3777, 3799, 4059, 4084], 'array,': [3535], 'clearly': [3543], 'evident': [3554], 'early': [3556, 3658], 'maintained': [3565], 'elevated': [3568], 'throughout': [3570], 'dose-dependent': [3587], 'concentrations': [3592], 'low': [3594, 3776], 'D).': [3600, 3634], 'Levels': [3601], 'similar': [3610], 'D),': [3618], 'inducer': [3621], 'yet': [3624], 'caused': [3626], 'enhancement': [3628], 'pretreatment': [3645], '(data': [3654, 3824, 3877, 4197, 4256], 'shown).': [3656, 3826, 3879, 4258], 'Several': [3657], 'reports': [3659], 'production': [3662, 3897, 4369], 'depend': [3704], '(50Toshchakov': [3707], 'B.W.': [3710], 'Perera': [3711], 'P.Y.': [3712], 'Thomas': [3713], 'Cody': [3715], 'Zhang': [3717], 'B.R.': [3720], 'Major': [3721], 'Hamilton': [3723], 'T.A.': [3724], 'Fenton': [3725], 'Vogel': [3727], 'S.N.': [3728], '3:': [3732], '392-398Crossref': [3733], '(678)': [3736], 'To': [3739, 4259], 'only': [3748], 'interferons.': [3755, 3901], 'Therefore,': [3756, 4323], 'explored': [3758], 'possibility': [3760, 3850, 4263], 'resting': [3770, 3873], 'ofIFNA': [3778], 'nearly': [3780], 'undetectable': [3781], '(Fig.2': [3785, 4066, 4310], '4-h': [3789], 'failed': [3794, 4252], 'change': [3796], 'transcript': [3798], 'either': [3801], 'several': [3807], 'IFNAspecies,': [3808], 'IFNW,': [3811], 'absent': [3813], 'unchanged': [3817], 'responded': [3828], 'normally': [3829], 'MX1and': [3834], 'TNFA.': [3835], 'Although': [3836, 3902], 'tightly': [3843], 'exists': [3851], 'release': [3854, 4156], 'preformed': [3855], 'upon': [3858], 'detected': [3868, 4041], 'Together,': [3880], 'independent': [3892], 'above': [3905], 'finding': [3918], 'IFN-regulated': [3925], 'activated.': [3933], 'ISG56': [3938], 'part': [3944], 'STAT1α': [3946, 4032], '(51Bandyopadhyay': [3947], 'Leonard': [3949], 'G.T.': [3951], 'Bandyopadhyay': [3952], 'Stark': [3954], 'Sen': [3956], 'G.C.': [3957], '270:': [3962], '19624-19629Abstract': [3963], '(126)': [3971], 'activate': [3975, 4131], 'Jak1/Tyk2-mediated': [3983], 'STATs': [3986], 'STAT3,': [4026], 'tyrosine-phosphorylated': [4028], 'STAT3.': [4031, 4127], '(p90)': [4033], 'STAT3α': [4035], '(p92)': [4036], 'predominant': [4039], 'species': [4040], 'phospho-STAT1': [4061], 'isoforms': [4062, 4065], 'consistently': [4077], 'decrease': [4080], 'basal': [4082], 'led': [4095], 'robust,': [4098], 'time-dependent': [4099], 'Stimulation': [4108], 'resulted': [4119], 'loss': [4122], 'Because': [4128], 'chemokines': [4129], '(52Mellado': [4134], 'Vila-Coro': [4136], 'Martinez': [4138], 'Rodriguez-Frade': [4140], 'embo.': [4145], '47:': [4147], '575-582Google': [4148], 'if': [4152], 'non-interferon': [4159], 'mediates': [4164, 4372], 'induction.': [4166], 'Our': [4167], 'profile': [4169], 'others': [4175], '(53Grenier': [4176, 4226], 'Dehoux': [4178, 4228], 'Boutten': [4180, 4230], 'Arce-Vicioso': [4182, 4232], 'Durand': [4184, 4234], 'Gougerot-Pocidalo': [4186, 4236], 'Chollet-Martin': [4188, 4238], '1413-1421Crossref': [4193, 4243], 'shown)': [4199], 'mRNA': [4206], 'oncostatin': [4208, 4250], 'This': [4210], 'gp130-activating': [4211], 'ligand,': [4212], 'Jak/STAT': [4217], 'pathways,': [4218], 'released': [4221, 4265, 4319], 'already': [4223], 'synthesized': [4224], 'pools': [4225], 'recombinant': [4248], 'M': [4251], 'investigate': [4260], 'further': [4261, 4316], 'responsible': [4268], 'MX1induction,': [4270], 'cell-free': [4271], 'unstimulated': [4274], 'TNFA,': [4290], 'measured': [4294], 'RT-PCR.': [4296], 'Conditioned': [4297], 'message': [4304], 'characterized': [4315], 'theTNFA-inducing': [4317], 'biologically': [4331], 'active,': [4332], 'does': [4334], 'contain': [4336], 'substance.': [4339], 'able': [4346], 'message,': [4349], 'sufficient': [4361], 'MX1.': [4365], 'Goog': [4391]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2027605044', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T12:00:32.893018', 'created_date': '2016-06-24'}
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