CD40 Stimulation Induces Pax5/BSAP and EBF Activation through a APE/Ref-1-dependent Redox Mechanism

Name: Work Video:
Duration: 3 min 30 s
Sonia Merluzzi; Massimo Moretti; Sandro Altamura; Patty Zwollo; Mikael Sigvardsson; Gaetano Vitale; Carlo E. Pucillo
{'id': 'https://openalex.org/W2027498615', 'doi': 'https://doi.org/10.1074/jbc.m305418200', 'title': 'CD40 Stimulation Induces Pax5/BSAP and EBF Activation through a APE/Ref-1-dependent Redox Mechanism', 'display_name': 'CD40 Stimulation Induces Pax5/BSAP and EBF Activation through a APE/Ref-1-dependent Redox Mechanism', 'publication_year': 2004, 'publication_date': '2004-01-01', 'ids': {'openalex': 'https://openalex.org/W2027498615', 'doi': 'https://doi.org/10.1074/jbc.m305418200', 'mag': '2027498615', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14594818'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305418200', 'pdf_url': 'http://www.jbc.org/article/S0021925820687348/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820687348/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042581781', 'display_name': 'Sonia Merluzzi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129043915', 'display_name': 'University of Udine', 'ror': 'https://ror.org/05ht0mh31', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I129043915']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sonia Merluzzi', 'raw_affiliation_strings': ['Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}, {'raw_affiliation_string': 'Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041755012', 'display_name': 'Massimo Moretti', 'orcid': 'https://orcid.org/0000-0002-5038-8619'}, 'institutions': [{'id': 'https://openalex.org/I129043915', 'display_name': 'University of Udine', 'ror': 'https://ror.org/05ht0mh31', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I129043915']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Moretti', 'raw_affiliation_strings': ['Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}, {'raw_affiliation_string': 'Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075889001', 'display_name': 'Sandro Altamura', 'orcid': 'https://orcid.org/0000-0002-6781-1073'}, 'institutions': [{'id': 'https://openalex.org/I129043915', 'display_name': 'University of Udine', 'ror': 'https://ror.org/05ht0mh31', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I129043915']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sandro Altamura', 'raw_affiliation_strings': ['Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}, {'raw_affiliation_string': 'Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046208385', 'display_name': 'Patty Zwollo', 'orcid': 'https://orcid.org/0000-0002-2257-940X'}, 'institutions': [{'id': 'https://openalex.org/I16285277', 'display_name': 'William & Mary', 'ror': 'https://ror.org/03hsf0573', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I16285277']}, {'id': 'https://openalex.org/I267592682', 'display_name': 'Williams (United States)', 'ror': 'https://ror.org/007zhvp17', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I267592682']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patty Zwollo', 'raw_affiliation_strings': ['Department of Biology, The College of William and Mary, Williamsburg, Virginia 23185'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, The College of William and Mary, Williamsburg, Virginia 23185', 'institution_ids': ['https://openalex.org/I16285277', 'https://openalex.org/I267592682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021313085', 'display_name': 'Mikael Sigvardsson', 'orcid': 'https://orcid.org/0000-0001-8527-7276'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Mikael Sigvardsson', 'raw_affiliation_strings': ['Laboratory of Cellular Differentiation, Department of Stem Cell Biology, Lund University, S-221 84 Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cellular Differentiation, Department of Stem Cell Biology, Lund University, S-221 84 Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025883513', 'display_name': 'Gaetano Vitale', 'orcid': 'https://orcid.org/0000-0002-7498-3551'}, 'institutions': [{'id': 'https://openalex.org/I129043915', 'display_name': 'University of Udine', 'ror': 'https://ror.org/05ht0mh31', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I129043915']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gaetano Vitale', 'raw_affiliation_strings': ['Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}, {'raw_affiliation_string': 'Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037840616', 'display_name': 'Carlo E. Pucillo', 'orcid': 'https://orcid.org/0000-0002-4872-6156'}, 'institutions': [{'id': 'https://openalex.org/I129043915', 'display_name': 'University of Udine', 'ror': 'https://ror.org/05ht0mh31', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I129043915']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Carlo Pucillo', 'raw_affiliation_strings': ['Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'M.A.T.I. Center of Excellence P.le Kolbe 4, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}, {'raw_affiliation_string': 'Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Udine, 33100 Udine, Italy', 'institution_ids': ['https://openalex.org/I129043915']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5037840616'], 'corresponding_institution_ids': ['https://openalex.org/I129043915'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 0.922, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.860022, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '279', 'issue': '3', 'first_page': '1777', 'last_page': '1786'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/naive-b-cell', 'display_name': 'Naive B cell', 'score': 0.4216425}], 'concepts': [{'id': 'https://openalex.org/C39347974', 'wikidata': 'https://www.wikidata.org/wiki/Q21135811', 'display_name': 'CD40', 'level': 4, 'score': 0.72892416}, {'id': 'https://openalex.org/C96926380', 'wikidata': 'https://www.wikidata.org/wiki/Q1737968', 'display_name': 'Germinal center', 'level': 4, 'score': 0.67318535}, {'id': 'https://openalex.org/C2778453870', 'wikidata': 'https://www.wikidata.org/wiki/Q188930', 'display_name': 'B cell', 'level': 3, 'score': 0.5882524}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51890904}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5016475}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.50158334}, {'id': 'https://openalex.org/C137756551', 'wikidata': 'https://www.wikidata.org/wiki/Q2386881', 'display_name': 'Immunoglobulin class switching', 'level': 4, 'score': 0.45238566}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.42538983}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.42409074}, {'id': 'https://openalex.org/C200180986', 'wikidata': 'https://www.wikidata.org/wiki/Q3269473', 'display_name': 'Naive B cell', 'level': 5, 'score': 0.4216425}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.31871045}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.27108097}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21192688}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15693712}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.13937438}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.11830279}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.105841964}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D043603', 'descriptor_name': 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D021581', 'descriptor_name': 'Active Transport, Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043603', 'descriptor_name': 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051757', 'descriptor_name': 'PAX5 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305418200', 'pdf_url': 'http://www.jbc.org/article/S0021925820687348/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.openaccessrepository.it/record/94961', 'pdf_url': 'https://www.openaccessrepository.it/record/94961/files/fulltext.pdf', 'source': {'id': 'https://openalex.org/S4306402478', 'display_name': 'INFM-OAR (INFN Catania)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210116497', 'host_organization_name': 'Istituto Nazionale di Fisica Nucleare, Sezione di Catania', 'host_organization_lineage': ['https://openalex.org/I4210116497'], 'host_organization_lineage_names': ['Istituto Nazionale di Fisica Nucleare, Sezione di Catania'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14594818', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305418200', 'pdf_url': 'http://www.jbc.org/article/S0021925820687348/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1547313148', 'https://openalex.org/W1583080998', 'https://openalex.org/W1601529283', 'https://openalex.org/W1612885055', 'https://openalex.org/W1632592488', 'https://openalex.org/W1878126797', 'https://openalex.org/W1882390326', 'https://openalex.org/W1911549571', 'https://openalex.org/W1932728046', 'https://openalex.org/W1949973946', 'https://openalex.org/W1952068404', 'https://openalex.org/W1963750108', 'https://openalex.org/W1967045730', 'https://openalex.org/W1972241251', 'https://openalex.org/W1973499398', 'https://openalex.org/W1982070877', 'https://openalex.org/W1995419071', 'https://openalex.org/W1996418577', 'https://openalex.org/W1996941638', 'https://openalex.org/W1999070086', 'https://openalex.org/W2003969944', 'https://openalex.org/W2008065206', 'https://openalex.org/W2008492683', 'https://openalex.org/W2018338402', 'https://openalex.org/W2021301407', 'https://openalex.org/W2027215231', 'https://openalex.org/W2034536848', 'https://openalex.org/W2035502959', 'https://openalex.org/W2041891155', 'https://openalex.org/W2049470832', 'https://openalex.org/W2057982973', 'https://openalex.org/W2058527659', 'https://openalex.org/W2058751432', 'https://openalex.org/W2060088582', 'https://openalex.org/W2064925886', 'https://openalex.org/W2070693959', 'https://openalex.org/W2072380594', 'https://openalex.org/W2082739985', 'https://openalex.org/W2086368930', 'https://openalex.org/W2092904354', 'https://openalex.org/W2094169218', 'https://openalex.org/W2103917924', 'https://openalex.org/W2105053762', 'https://openalex.org/W2112340832', 'https://openalex.org/W2115374084', 'https://openalex.org/W2121185017', 'https://openalex.org/W2126524404', 'https://openalex.org/W2128635872', 'https://openalex.org/W2132965191', 'https://openalex.org/W2135585445', 'https://openalex.org/W2143489424', 'https://openalex.org/W2148091108', 'https://openalex.org/W2156561249', 'https://openalex.org/W2160000876', 'https://openalex.org/W2161315255', 'https://openalex.org/W2165949745', 'https://openalex.org/W2171373646', 'https://openalex.org/W2234240067', 'https://openalex.org/W240498459', 'https://openalex.org/W37150070', 'https://openalex.org/W4213387034', 'https://openalex.org/W4293247451', 'https://openalex.org/W4313331004', 'https://openalex.org/W43845382', 'https://openalex.org/W57180152'], 'related_works': ['https://openalex.org/W3040048187', 'https://openalex.org/W2595956860', 'https://openalex.org/W2137268127', 'https://openalex.org/W2136877952', 'https://openalex.org/W207300376', 'https://openalex.org/W2007314562', 'https://openalex.org/W1994031217', 'https://openalex.org/W1877571168', 'https://openalex.org/W174135683', 'https://openalex.org/W1576474939'], 'abstract_inverted_index': {'CD40': [0, 30, 112, 131, 236, 266, 348, 367, 472, 499, 523, 588, 688, 2505, 2738], 'is': [1, 168, 237, 404, 473, 505, 513, 773, 884, 928, 1050, 1077, 1410, 1417, 1566, 1582, 1695, 1846, 1911, 2121, 2418, 2467, 2522, 3889], 'a': [2, 76, 238, 312, 474, 685, 885, 888, 1013, 1156, 1569, 1696, 1916, 1966, 1972, 2071, 2124, 2170, 2400, 2588, 3092, 3105, 3164, 3259, 3412, 3425, 3712, 3858, 3974, 4230, 4311], 'member': [3, 239, 886], 'of': [4, 27, 47, 55, 142, 153, 164, 186, 240, 263, 283, 291, 378, 389, 400, 422, 518, 522, 532, 541, 763, 768, 779, 855, 871, 880, 887, 891, 906, 1055, 1155, 1158, 1403, 1405, 1580, 1604, 1636, 1645, 1728, 1738, 1829, 1837, 2066, 2070, 2133, 2167, 2181, 2206, 2232, 2405, 2410, 2424, 2431, 2461, 2472, 2481, 2486, 2495, 2516, 2530, 2548, 2591, 2620, 2633, 2656, 2766, 2849, 2864, 2919, 2990, 3083, 3275, 3279, 3331, 3362, 3396, 3451, 3465, 3468, 3476, 3486, 3535, 3551, 3560, 3566, 3582, 3586, 3655, 3701, 3719, 3727, 3749, 3763, 3790, 3820, 3840, 3857, 3894, 3903, 3946, 3985, 3999, 4055, 4068, 4080, 4089, 4097, 4119, 4139, 4205, 4232, 4266, 4313, 4326, 4361, 4365, 4368, 4372, 4376, 4384, 4455, 4499], 'the': [5, 56, 60, 70, 137, 140, 149, 162, 183, 187, 208, 241, 292, 296, 306, 373, 376, 385, 398, 419, 423, 444, 488, 516, 590, 764, 769, 777, 861, 868, 878, 881, 896, 935, 1008, 1053, 1080, 1152, 1184, 1265, 1331, 1349, 1400, 1589, 1601, 1646, 1652, 1838, 1853, 1880, 1885, 1975, 2130, 2178, 2230, 2403, 2411, 2429, 2459, 2493, 2511, 2514, 2526, 2542, 2549, 2556, 2763, 2904, 2912, 2956, 2971, 3023, 3044, 3060, 3139, 3176, 3189, 3236, 3253, 3270, 3276, 3370, 3374, 3377, 3394, 3404, 3444, 3461, 3533, 3546, 3592, 3614, 3656, 3682, 3741, 3760, 3769, 3814, 3818, 3841, 3885, 3892, 3900, 3940, 3958, 3966, 3982, 4052, 4065, 4112, 4132, 4233, 4254, 4290, 4322, 4338, 4344, 4395, 4441, 4451, 4462, 4492], 'growing': [6, 242, 490], 'tumor': [7, 243, 491], 'necrosis': [8, 244, 492], 'factor': [9, 72, 245, 308, 493, 1649, 1962, 2021], 'receptor': [10, 246, 476, 494], 'family': [11, 247, 890, 1740], 'that': [12, 69, 129, 161, 179, 196, 207, 223, 248, 305, 365, 397, 415, 432, 443, 459, 485, 894, 1563, 1576, 1595, 1840, 1922, 1970, 2053, 2140, 2397, 2503, 2536, 2555, 2571, 3821, 3993, 4127, 4228, 4252, 4283, 4410], 'has': [13, 249, 693, 2399], 'been': [14, 250, 694, 1149], 'shown': [15, 251, 1562, 2223], 'to': [16, 51, 82, 139, 170, 218, 252, 287, 318, 375, 406, 454, 487, 681, 984, 1584, 1639, 1833, 2177, 2212, 2224, 2476, 2491, 2513, 2524, 2566, 2945, 3034, 3098, 3269, 3424, 3619, 3668, 3676, 3681, 3768, 3801, 3850, 3948, 3964, 3987, 4057, 4070, 4082, 4106, 4169, 4248, 4272, 4336, 4407], 'play': [17, 253], 'important': [18, 254, 904], 'roles': [19, 255], 'in': [20, 80, 107, 116, 256, 316, 343, 352, 515, 537, 776, 860, 867, 1074, 1151, 1408, 1419, 1642, 1660, 1700, 1707, 1723, 1884, 1974, 2023, 2129, 2219, 2229, 2402, 2463, 2497, 2593, 2660, 2672, 2752, 2780, 2823, 2861, 2916, 3122, 3129, 3147, 3196, 3242, 3284, 3342, 3403, 3434, 3460, 3711, 3724, 3746, 3776, 3891, 3929, 3944, 4077, 4103, 4174, 4208, 4270, 4321, 4398, 4446, 4450, 4496], 'T': [21, 37, 257, 273, 511, 2634], 'cell-mediated': [22, 258], 'B': [23, 28, 40, 84, 101, 109, 125, 144, 259, 264, 276, 320, 337, 345, 361, 380, 479, 525, 545, 787, 798, 831, 837, 846, 856, 873, 932, 1056, 1065, 1071, 1414, 1637, 1967, 2414, 2425, 2433, 2465, 2482, 2518, 2594, 2604, 2921, 3587, 3687], 'lymphocyte': [24, 260], 'activation.': [25, 86, 174, 261, 322, 410, 2597], 'Ligation': [26, 262], 'cell': [29, 41, 85, 94, 102, 265, 277, 321, 330, 338, 788, 799, 832, 838, 847, 857, 863, 874, 933, 1072, 1420, 2415, 2426, 2434, 2616, 3037, 4210, 4259], 'by': [31, 191, 267, 427, 2075, 2123, 2624, 2636, 2725, 2769, 3163, 3175, 3188, 3299, 3601, 3617, 3827, 3909, 4214, 4241], 'CD154,': [32, 268], 'mainly': [33, 269, 506], 'expressed': [34, 106, 270, 342, 477, 507, 851], 'on': [35, 271, 478, 508, 524, 992, 2954, 3091, 3309, 3411, 3537, 4216], 'activated': [36, 143, 272, 379, 509, 2517], 'cells,': [38, 145, 274, 381, 512, 1415, 2519], 'stimulates': [39, 275], 'proliferation,': [42, 278, 528, 1422, 2767], 'differentiation,': [43, 279], 'isotype': [44, 280, 549], 'switching,': [45, 281], 'up-regulation': [46, 282, 531], 'surface': [48, 284, 475, 534], 'molecules': [49, 285, 535], 'contributing': [50, 286], 'antigen': [52, 288, 538], 'presentation,': [53, 289, 539], 'development': [54, 290, 858, 908, 1054, 1073, 2427], 'germinal': [57, 293, 542], 'center,': [58, 294, 543], 'and': [59, 98, 111, 118, 156, 193, 195, 212, 230, 295, 334, 347, 354, 392, 429, 431, 448, 466, 481, 500, 547, 651, 690, 834, 864, 902, 943, 975, 987, 995, 1067, 1070, 1379, 1423, 1594, 1722, 1736, 1826, 1851, 1918, 2059, 2144, 2217, 2381, 2413, 2436, 2488, 2490, 2541, 2544, 2560, 2578, 2600, 2632, 2704, 2709, 2717, 2731, 2801, 2806, 2816, 2837, 2842, 2858, 2903, 2970, 3059, 3096, 3173, 3182, 3186, 3233, 3263, 3307, 3365, 3421, 3529, 3554, 3557, 3591, 3598, 3610, 3662, 3697, 3737, 3759, 3829, 3838, 3906, 3927, 3954, 4005, 4011, 4019, 4049, 4060, 4073, 4085, 4095, 4109, 4136, 4172, 4197, 4224, 4263, 4268, 4303, 4319, 4343, 4351, 4387, 4417, 4448, 4491], 'humoral': [61, 297], 'memory': [62, 298, 544], 'response.': [63, 299, 520], 'In': [64, 300, 679, 761, 1412, 1572, 2532, 3369, 3520], 'this': [65, 301, 2473, 2498, 2753, 2758], 'study': [66, 302], 'we': [67, 159, 205, 303, 395, 441, 1574, 2534, 2553], 'demonstrate': [68, 304, 2502], 'redox': [71, 307, 1570, 1648, 1825, 1849], 'APE/Ref-1': [73, 134, 165, 180, 197, 309, 370, 401, 416, 433, 1650, 1691, 1830, 1909, 2496, 2508, 2537, 2592, 3160, 3469, 3487, 3657], 'acts': [74, 310], 'as': [75, 311, 1965, 2019, 2056, 2613, 2908, 2975, 3086, 3386, 3490, 3973, 4199, 4201, 4389], 'key': [77, 313], 'signaling': [78, 314, 689], 'intermediate': [79, 315], 'response': [81, 317, 4271], 'CD40-mediated': [83, 172, 319, 408, 2479, 2596], 'The': [87, 323, 496, 925, 1824, 1843, 2164, 2204, 2470, 2720, 2889, 3112, 3226, 3407, 3484, 3604, 3653, 3670, 3752, 3771, 3845, 3914, 3933, 3976, 4003, 4203, 4330, 4354, 4401, 4438], 'transcription': [88, 324, 783, 842, 869, 892, 1730], 'factors': [89, 325, 843, 893, 1731], 'Pax5a': [90, 117, 155, 173, 192, 211, 224, 326, 353, 391, 409, 428, 447, 460, 785, 938, 974, 1049, 1145, 1416, 1564, 1581, 1605, 1661, 2417, 2489, 2543, 2559, 2572, 3187, 3536, 3571, 4010], 'or': [91, 327, 781, 786, 1002, 3067, 3074, 3154, 3463, 3472, 3479, 3578, 4062, 4076, 4324, 4453], 'BSAP': [92, 328], '(B': [93, 329], 'lineage-specific': [95, 331, 789, 800], 'activator': [96, 332, 790, 801], 'protein)': [97, 333], 'EBF': [99, 119, 194, 201, 213, 215, 229, 335, 355, 430, 437, 449, 451, 465, 835, 2054, 2134, 2168, 2221, 2398, 2462, 2487, 2539, 2545, 2561, 2563, 2577, 3538, 3969], '(early': [100, 336, 836], 'factor)': [103, 339, 839], 'are': [104, 340, 840, 850, 865, 903, 1831, 2137, 4124], 'constitutively': [105, 341, 4284], 'spleen': [108, 344], 'cells': [110, 346, 480, 484, 1066, 1638, 2466, 2595, 2605, 2623, 2635, 2722, 2777, 2820, 2852, 2984, 3688, 3710, 3772, 3807, 4100, 4166, 4280, 4282, 4307, 4345, 4409, 4442, 4463], 'cross-linking': [113, 349], 'induces': [114, 350], 'increases': [115, 351], 'binding': [120, 151, 216, 234, 356, 387, 452, 470, 900, 1146, 1352, 1611, 1662, 1726, 2050, 2119, 2216, 2528, 2564, 2582, 3343, 3378, 3523, 3540], 'activity': [121, 152, 217, 357, 388, 453, 778, 1565, 1663, 1710, 1727, 1850, 1882, 2120, 2529, 2540, 2565], 'compared': [122, 358], 'with': [123, 228, 359, 464, 986, 1018, 1586, 1608, 1657, 2175, 2226, 2576, 2627, 2662, 2676, 2735, 2786, 2827, 2856, 2987, 3137, 3143, 3231, 3235, 3297, 3301, 3316, 3328, 3359, 3373, 3437, 3443, 3448, 3473, 3545, 3570, 3577, 3692, 3740, 3794, 3813, 3833, 3930, 4116, 4244, 4298], 'nonstimulated': [124, 360], 'cells.': [126, 362, 3770], 'We': [127, 175, 363, 411, 1559], 'show': [128, 160, 206, 364, 396, 442, 2535, 3674], 'upon': [130, 366, 2504], 'antibody-mediated': [132, 368, 2506], 'cross-linking,': [133, 369, 2507], 'translocates': [135, 371, 2509], 'from': [136, 372, 2510, 2608, 2646, 3923, 4017, 4278], 'cytoplasm': [138, 374, 2512], 'nucleus': [141, 377, 2515], 'where': [146, 382, 2135, 2520], 'it': [147, 383, 1914, 2521], 'modulates': [148, 384, 2538], 'DNA': [150, 233, 386, 469, 899, 1610, 1703, 1725, 2049, 2118, 2215, 2527, 2581, 3387, 3397, 3539, 3742, 3990, 4218, 4363, 4392, 4396], 'both': [154, 390, 3904], 'EBF.': [157, 393], 'Moreover,': [158, 394, 1634, 2552, 3563], 'repression': [163, 399], 'protein': [166, 402, 594, 655, 791, 1698, 1839, 1969, 2015, 2980, 3471], 'production': [167, 403], 'able': [169, 405, 2523], 'block': [171, 407], 'also': [176, 412, 2017, 2138, 2420], 'provide': [177, 413], 'evidence': [178, 414], 'can': [181, 225, 417, 461, 2573], 'modulate': [182, 231, 418, 467, 2579], 'cooperative': [184, 420, 2546], 'activation': [185, 421, 2173, 2485, 2547], 'blk': [188, 424, 1290, 2382, 2550], 'promoter': [189, 425, 1977, 3861, 3883], 'operated': [190, 426], 'might': [198, 434], 'directly': [199, 435], 'regulate': [200, 436], 'functional': [202, 438, 1401, 2227], 'activity.': [203, 235, 439, 471, 2583], 'Finally,': [204, 440], 'interaction': [209, 445, 497, 2557], 'between': [210, 446, 498, 687, 2558], 'enhances': [214, 450, 2562], 'its': [219, 232, 455, 468, 501, 2567, 2580], 'consensus': [220, 456, 2568], 'sequence,': [221, 457, 2569], 'suggesting': [222, 458, 2570], 'physically': [226, 462, 2574], 'interact': [227, 463, 985, 1585, 2225, 2575], 'certain': [482], 'accessory': [483], 'belong': [486], 'pleiotropic': [489], 'superfamily.': [495], 'ligand': [502], '(CD154),': [503], 'which': [504, 2761, 3418, 3787, 3888], 'CD4+': [510], 'critical': [514], 'regulation': [517, 2404, 3902], 'immune': [519], 'Engagement': [521], 'lymphocytes': [526, 2483], 'promotes': [527, 2484], 'cytokine': [529], 'production,': [530], 'various': [533], 'involved': [536, 866, 1418, 1699], 'formation': [540], 'cell,': [546], 'antibody': [548, 3168, 3180, 3193], 'switching': [550, 1426], '(1.Durie': [551], 'F.H.': [552], 'Foy': [553], 'T.M.': [554], 'Noelle': [555], 'R.J.': [556], 'Res.': [557, 1624, 1682, 1759, 1814, 3217, 3511, 3873, 4154], 'Immunol.': [558, 604, 645, 1201, 1256, 1441, 1471, 1484, 1540, 1553, 2316, 2389], '1994;': [559, 605, 707, 917, 1094, 1322, 1554, 1901], '145': [560], '(244–249):': [561], '200-205Crossref': [562], 'PubMed': [563, 583, 627, 674, 710, 733, 756, 920, 968, 1044, 1100, 1118, 1140, 1179, 1219, 1237, 1260, 1285, 1310, 1328, 1374, 1394, 1459, 1488, 1511, 1524, 1629, 1686, 1717, 1763, 1783, 1797, 1819, 1874, 1904, 1955, 1989, 2009, 2044, 2094, 2113, 2159, 2199, 2245, 2266, 2285, 2305, 2320, 2335, 2356, 2376, 2453, 3054, 3221, 3515, 3648, 3877, 4044, 4158, 4433], 'Scopus': [564, 584, 628, 675, 711, 734, 757, 921, 969, 1045, 1101, 1119, 1141, 1180, 1238, 1261, 1286, 1311, 1375, 1395, 1460, 1489, 1630, 1687, 1718, 1764, 1784, 1798, 1820, 1875, 1905, 1956, 1990, 2010, 2045, 2095, 2114, 2160, 2200, 2246, 2267, 2286, 2306, 2321, 2336, 2357, 2377, 2454, 3055, 3222, 3516, 3649, 3878, 4045, 4159, 4434], '(23)': [565], 'Google': [566, 586, 608, 630, 649, 677, 713, 736, 759, 923, 971, 1047, 1103, 1121, 1143, 1182, 1205, 1220, 1240, 1263, 1288, 1313, 1329, 1347, 1377, 1397, 1445, 1462, 1475, 1491, 1512, 1525, 1544, 1557, 1632, 1689, 1720, 1766, 1786, 1800, 1822, 1877, 1907, 1958, 1992, 2012, 2047, 2097, 2116, 2162, 2202, 2248, 2269, 2288, 2308, 2323, 2338, 2359, 2379, 2393, 2456, 3057, 3224, 3518, 3651, 3880, 4047, 4161, 4436], 'Scholar,': [567, 609, 714, 737, 1104, 1122, 1206, 1221, 1314, 1446, 1463, 1476, 1492, 1513, 1526, 1545, 1767, 1787, 1801, 1993, 2098, 2270, 2289, 2309, 2324], '2.Locksley': [568], 'R.M.': [569], 'Killeen': [570], 'N.': [571], 'Lenardo': [572], 'M.J.': [573, 1296, 2149], 'Cell.': [574, 1093, 1174, 1214, 1454, 1506, 1519, 1867, 2039, 2108, 2280, 2371], '2001;': [575, 2445, 3640], '104:': [576], '487-501Abstract': [577], 'Full': [578, 580, 671, 963, 965, 1039, 1041, 1097, 1135, 1137, 1232, 1234, 1280, 1282, 1305, 1307, 1325, 1871, 2300, 2302, 2351, 2353, 2448, 2450, 3643, 3645, 4039, 4041], 'Text': [579, 581, 672, 964, 966, 1040, 1042, 1098, 1136, 1138, 1233, 1235, 1281, 1283, 1306, 1308, 1326, 1872, 2301, 2303, 2352, 2354, 2449, 2451, 3644, 3646, 4040, 4042], 'PDF': [582, 673, 967, 1043, 1099, 1139, 1236, 1284, 1309, 1327, 1873, 2304, 2355, 2452, 3647, 4043], '(3038)': [585], 'Scholar).': [587, 678, 760, 924, 972, 1048, 1144, 1558, 1633, 1690, 1823, 1908, 1959, 2013, 2048, 2117, 2163, 2203, 2394, 3225, 3519, 3652, 3881, 4162, 4437], 'activates': [589], 'c-Jun': [591], 'NH2-terminal': [592], 'kinase-stress-activated': [593], 'kinase,': [595], 'NF-κB': [596], '(3.Berberich': [597], 'I.': [598, 611, 1088], 'Shu': [599, 612], 'G.L.': [600], 'Clark': [601, 620], 'E.A.': [602, 621], 'J.': [603, 623, 644, 704, 957, 1033, 1200, 1245, 1255, 1299, 1319, 1368, 1390, 1440, 1452, 1470, 1539, 1552, 1712, 1779, 1793, 1860, 1979, 1985, 1995, 2080, 2102, 2147, 2155, 2185, 2235, 2241, 2252, 2274, 2315, 2329, 2388, 3637, 4033], '153:': [606, 1555], '4357-4366PubMed': [607], '4.Berberich': [610], 'G.': [613, 1338, 1613, 1621, 1665, 1677, 1742, 1754, 1771, 1803, 1811, 1938, 3200, 3212, 3494, 3506], 'Siebelt': [614], 'F.': [615, 1465, 1502, 1773], 'Woodgett': [616], 'J.R.': [617], 'Kyriakis': [618], 'J.M.': [619], 'EMBO': [622, 1389, 1778, 1792, 1984, 2154, 2240], '1996;': [624, 646, 668, 1216, 1277, 1344, 1371, 1541], '15:': [625], '92-101Crossref': [626], '(174)': [629], 'Scholar),': [631, 650, 1183, 1241, 1264, 1289, 1330, 1348, 1398, 1721, 1878, 2249, 2339, 2360, 2380, 2457], 'p38': [632], 'kinase': [633, 656, 3304], '(5.Sutherland': [634], 'C.L.': [635, 697], 'Heath': [636], 'A.W.': [637], 'Pelech': [638], 'S.L.': [639, 1106, 1467], 'Young': [640], 'P.R.': [641], 'Gold': [642], 'M.R.': [643, 1675, 1752, 3210, 3504], '157:': [647], '3381-3390PubMed': [648], 'extracellular': [652], 'signal-regulated': [653], 'kinase-mitogen-activated': [654], '(MAPK)': [657], 'pathways': [658], '(6.Li': [659], 'Y.S.': [660, 1359], 'Wasserman': [661], 'R.': [662, 956, 1032, 1384, 1983, 2003, 2035, 2088, 2106, 2153, 2193, 2239, 2260, 2278, 2295, 2346, 4032], 'Hayakawa': [663], 'K.': [664, 950, 952, 1026, 1028, 2027, 2647, 4026, 4028], 'Hardy': [665, 1360], 'R.R.': [666, 1361], 'Immunity.': [667, 1131, 1228, 1276, 2296, 2347, 2444], '5:': [669, 1278], '527-535Abstract': [670], '(311)': [676], 'addition': [680, 3395], 'these': [682, 1406, 2207, 2585, 3521], 'serine-threonine': [683], 'kinases,': [684], 'link': [686], 'phosphatidylinositol': [691], '3-kinase': [692], 'suggested': [695], '(7.Ren': [696], 'Morio': [698], 'T.': [699, 749, 910, 1247, 1249, 1777, 1791, 1893, 2367], 'Fu': [700], 'S.M.': [701, 1862], 'Geha': [702], 'R.S.': [703], 'Exp.': [705, 1369, 2330], 'Med.': [706, 1370, 2331], '179:': [708], '673-680Crossref': [709], '(216)': [712], '8.Fruman': [715], 'D.A.': [716], 'Snapper': [717, 1531], 'S.B.': [718], 'Yballe': [719], 'C.M.': [720, 1532], 'Davidson': [721], 'L.': [722, 1191, 1431, 1478, 1500, 1615, 1669, 1746, 1805, 1930, 2104, 2276, 3204, 3498, 3630], 'Yu': [723], 'J.Y.': [724], 'Alt': [725, 1501], 'F.W.': [726], 'Cantley': [727], 'L.C.': [728], 'Science.': [729, 752], '1999;': [730, 753, 2373, 2390], '283:': [731, 754], '393-397Crossref': [732], '(572)': [735], '9.Suzuki': [738], 'H.': [739, 948, 1024, 1940, 2151, 3870, 4024, 4151], 'Terauchi': [740], 'Y.': [741, 747, 1551], 'Fujiwara': [742], 'M.': [743, 1092, 1112, 1128, 1130, 1172, 1195, 1386, 1435, 1504, 1515, 1530, 1934, 2033, 2291, 2293, 2342, 2344, 2365, 2369, 2387, 2439, 2443, 3868, 4149], 'Aizawa': [744], 'S.': [745, 751, 954, 1030, 1166, 1193, 1251, 1318, 1433, 1769, 1789, 1889, 1899, 1928, 3866, 4030], 'Yazaki': [746], 'Kadowaki': [748], 'Koyasu': [750], '390-392Crossref': [755], '(427)': [758], 'each': [762, 3802, 4399], 'above': [765], 'pathways,': [766], 'one': [767, 780, 3910], 'major': [770], 'final': [771], 'outcomes': [772], 'an': [774, 978, 1577, 1596, 1654, 1658, 2057, 2067], 'alteration': [775], 'more': [782], 'factors.': [784], '(BSAP)': [792], '1The': [793], 'abbreviations': [794], 'used': [795, 3062, 3283, 3963], 'are:': [796], 'BSAP,': [797], 'protein;': [802], 'DTT,': [803, 3006], 'dithiothreitol;': [804], 'mAb,': [805], 'monoclonal': [806], 'antibody;': [807], 'CMV,': [808], 'cytomegalovirus;': [809], 'luc,': [810], 'luciferase;': [811], 'GST,': [812], 'glutathione': [813], 'S-transferase;': [814], 'EMSA,': [815], 'electrophoretic': [816, 3068], 'mobility': [817, 3069], 'shift': [818, 3070], 'assay;': [819], 'PBS,': [820, 3130], 'phosphate-buffered': [821], 'saline;': [822], 'Tc,': [823], 'tetracycline;': [824], 'ROS,': [825], 'reactive': [826], 'oxygen': [827], 'species;': [828], 'EBF,': [829], 'early': [830, 907], 'factor.': [833], 'two': [841, 3853], 'essential': [844, 1051, 1847], 'for': [845, 989, 1052, 1848, 2428, 2746, 2897, 2951, 2964, 3017, 3031, 3064, 3116, 3245, 3336, 3706, 3731, 3756, 3783, 4256, 4289, 4301, 4382, 4393, 4420, 4485], 'development.': [848], 'Both': [849], 'at': [852, 1007, 1079, 2714, 2741, 2757, 2893, 2900, 2960, 2967, 3020, 3027, 3076, 3119, 3151, 3157, 3248, 3339, 3399, 3430, 3608, 3734, 3780, 4129, 4143, 4184, 4310, 4348, 4414, 4481, 4488], 'all': [853, 3036, 3994], 'stages': [854, 2423], 'except': [859], 'plasma': [862], 'control': [870, 2525, 3856], 'several': [872, 1729, 2406], 'restricted': [875], 'genes.': [876], 'Pax5a,': [877], 'product': [879], 'Pax5': [882, 926, 1058], 'gene,': [883], 'multigene': [889], 'share': [895], 'paired': [897, 1602], 'box': [898], 'domain': [901, 1603, 1845, 2174], 'regulators': [905], '(10.Strachan': [909], 'Read': [911], 'A.P.': [912], 'Curr.': [913], 'Opin.': [914], 'Genet.': [915], 'Dev.': [916, 1114, 2005, 2090, 2195, 2262], '4:': [918, 1486], '427-438Crossref': [919], '(217)': [922], 'gene': [927, 1059, 1334], 'alternatively': [929], 'spliced': [930], 'during': [931, 2421], 'development:': [934], 'predominant': [936], 'form': [937, 1579, 1591], '(full-length': [939], 'Pax5),': [940], 'Pax5b,': [941], 'Pax5d,': [942], 'Pax5e': [944, 996], '(11.Zwollo': [945, 1021, 4021], 'P.': [946, 1022, 1084, 1108, 1168, 1316, 1340, 1388, 1494, 1671, 1748, 1944, 2363, 2385, 3206, 3500, 4022], 'Arrieta': [947, 1023, 4023], 'Ede': [949, 1025, 4025], 'Molinder': [951, 1027, 4027], 'Desiderio': [953, 1029, 1317, 4029], 'Pollock': [955, 1031, 4031], 'Biol.': [958, 1034, 1175, 1215, 1300, 1320, 1455, 1507, 1520, 2040, 2109, 2281, 2372, 3638, 4034], 'Chem.': [959, 1035, 1301, 1321, 3639, 4035], '1997;': [960, 1036, 1115, 1202, 1229, 1257, 1442, 2297, 2317, 2348, 4036, 4155], '272:': [961, 1037, 4037], '10160-10168Abstract': [962, 1038, 4038], '(62)': [970, 1046, 4046], 'Only': [973], 'Pax5d': [976, 994, 4012], 'possess': [977], 'intact': [979], 'DNA-binding': [980], 'domain,': [981], 'enabling': [982], 'them': [983], 'compete': [988], 'Pax5-binding': [990], 'sites': [991, 1147, 1407], 'DNA.': [993], 'do': [997], 'not': [998, 3526, 3673], 'have': [999, 1062, 1148, 1560], 'transactivation,': [1000], 'repression,': [1001], 'partial': [1003], 'homeodomain': [1004], 'homology': [1005, 2176, 3675], 'regions': [1006, 2228], 'C': [1009], 'terminus': [1010], 'but': [1011, 2458], 'present': [1012], '42-amino': [1014], 'acid': [1015], 'novel': [1016, 2125, 2589], 'sequence': [1017, 1856, 3274, 3654, 3978], 'unknown': [1019], 'function': [1020, 1841, 2437], 'cells;': [1057], 'knockout': [1060], 'mice': [1061, 1076, 2612], 'no': [1063], 'mature': [1064, 1413, 2432, 2464], 'serum': [1068, 2680, 2790, 2831, 3367, 3798], 'immunoglobulins,': [1069], 'such': [1075], 'arrested': [1078], 'pro-B': [1081], 'stage': [1082], '(12.Urbanek': [1083], 'Wang': [1085, 1165, 1772], 'Z.Q.': [1086], 'Fetka': [1087], 'Wagner': [1089], 'E.F.': [1090], 'Busslinger': [1091, 1111, 1129, 1171, 1194, 1434, 2442], '79:': [1095], '901-912Abstract': [1096], '(680)': [1102], '13.Nutt': [1105], 'Urbanek': [1107], 'Rolink': [1109], 'A.': [1110, 1124, 1225, 1253, 1667, 1673, 1744, 1750, 1900, 1932, 1981, 1999, 2084, 2100, 2189, 2237, 2256, 2272, 2311, 2441, 3202, 3208, 3496, 3502, 3626, 3634, 3636], 'Genes': [1113, 2004, 2089, 2194, 2261], '11:': [1116, 1509, 1781, 1795], '476-491Crossref': [1117], '(340)': [1120], '14.Souabni': [1123], 'Cobaleda': [1125], 'C.': [1126, 1619, 1679, 1756, 1809, 1866, 1997, 2029, 2031, 2082, 2187, 2254, 2328, 3214, 3508], 'Schebesta': [1127], '2002;': [1132, 1714], '17:': [1133], '781-793Abstract': [1134], '(187)': [1142], 'identified': [1150, 1964, 2018], 'regulatory': [1153], 'sequences': [1154, 2063, 2139], 'number': [1157], 'genes,': [1159], 'including': [1160, 1732], 'mb-1,': [1161, 3289], 'CD19': [1162], '(15.Kozmik': [1163], 'Z.': [1164], 'Dorfler': [1167], 'Adams': [1169], 'B.': [1170, 1498], 'Mol.': [1173, 1213, 1453, 1505, 1518, 2038, 2107, 2279, 2370], '1992;': [1176, 1472, 1485, 1780, 1794], '12:': [1177], '2662-2672Crossref': [1178], '(293)': [1181], 'k-light': [1185], 'chain': [1186, 1267], '(16.Thienes': [1187, 1427], 'C.P.': [1188, 1428], 'De': [1189, 1429], 'Monte': [1190, 1430], 'Monticelli': [1192, 1432], 'Gould': [1196, 1436], 'H.J.': [1197, 1437], 'Vercelli': [1198, 1438], 'D.': [1199, 1439, 1536, 1617, 1807, 3624, 3628], '158:': [1203, 1443], '5874-5882PubMed': [1204, 1444], '17.Roque': [1207], 'M.C.': [1208], 'Smith': [1209], 'P.A.': [1210], 'Blasquez': [1211], 'V.C.': [1212], '16:': [1217], '3138-3155Crossref': [1218], '18.Shaffer': [1222], 'A.L.': [1223, 1342, 1950], 'Peng': [1224], 'Schlissel': [1226], 'M.S.': [1227], '6:': [1230], '131-143Abstract': [1231], '(77)': [1239], 'VpreB1,': [1242], 'λ5': [1243, 2250], '(19.Tian': [1244], 'Okabe': [1246], 'Miyazaki': [1248], 'Takeshita': [1250], 'Kudo': [1252], 'Eur.': [1254, 2314], '27:': [1258, 2318], '750-755Crossref': [1259], '(34)': [1262], 'J': [1266], '(20.Rinkenberger': [1268], 'J.L.': [1269, 1365], 'Wallin': [1270], 'J.J.': [1271], 'Johnson': [1272], 'K.W.': [1273], 'Koshland': [1274], 'M.E.': [1275], '377-386Abstract': [1279], '(101)': [1287, 2046, 3650], '(21.Lin': [1291], 'Y.H.': [1292], 'Shin': [1293], 'E.J.': [1294], 'Campbell': [1295], 'Niederhuber': [1297], 'J.E.': [1298], '1995;': [1302, 1391, 2156, 3874], '270:': [1303], '25968-25975Abstract': [1304], '(22)': [1312, 2322], '22.Zwollo': [1315], '269:': [1323], '15310-15317Abstract': [1324], 'mouse': [1332, 2814, 3177, 3190], 'engrailed': [1333], '(23.Song': [1335], 'D.L.': [1336], 'Chalepakis': [1337], 'Gruss': [1339, 1387], 'Joyner': [1341], 'Development.': [1343], '122:': [1345], '627-635PubMed': [1346], 'human': [1350], 'X-box': [1351], 'protein-1': [1353], '(24.Reimold': [1354], 'A.M.': [1355], 'Ponath': [1356], 'P.D.': [1357], 'Li': [1358, 1495], 'David': [1362], 'C.S.': [1363], 'Strominger': [1364], 'Glimcher': [1366, 1499], 'L.H.': [1367], '183:': [1372], '393-401Crossref': [1373], '(153)': [1376], 'Scholar)': [1378, 3058, 4048], 'p53': [1380], '(25.Stuart': [1381], 'E.T.': [1382], 'Haffner': [1383], 'Oren': [1385], '14:': [1392, 2157, 2446], '5638-5645Crossref': [1393], '(211)': [1396], 'although': [1399], 'significance': [1402], 'many': [1404], 'vivo': [1409], 'unknown.': [1411, 2469], 'activation,': [1421], 'Ig': [1424], 'class': [1425], '26.Waters': [1447], 'S.H.': [1448], 'Saikh': [1449], 'K.U.': [1450], 'Stavnezer': [1451], '1989;': [1456], '9:': [1457], '5594-5601Crossref': [1458], '(56)': [1461], '27.Liao': [1464], 'Giannini': [1466], 'Birshtein': [1468, 1516, 1537], 'B.K.': [1469, 1517, 1538], '148:': [1473], '2909-2917PubMed': [1474], '28.Xu': [1477], 'Kim': [1479], 'M.G.': [1480], 'Marcu': [1481], 'K.B.': [1482], 'Int.': [1483], '875-887Crossref': [1487], '(35)': [1490], '29.Rothman': [1493], 'S.C.': [1496], 'Gorham': [1497], 'Boothby': [1503], '1991;': [1508, 1868, 1986, 2242], '5551-5561Crossref': [1510], '30.Singh': [1514], '1993;': [1521, 2006, 2041, 2091, 2110, 2196, 2263, 2282], '13:': [1522, 2042, 2111, 2283], '3611-3622Crossref': [1523], '31.Michaelson': [1527], 'J.S.': [1528], 'Singh': [1529], 'Sha': [1533], 'W.C.': [1534], 'Baltimore': [1535], '156:': [1542], '2828-2839PubMed': [1543], '32.Neurath': [1546], 'M.F.': [1547], 'Strober': [1548], 'W.': [1549], 'Wakatsuki': [1550], '730-742PubMed': [1556], 'previously': [1561], 'regulated': [1567], 'through': [1568], 'mechanism.': [1571], 'particular': [1573], 'demonstrated': [1575], 'oxidized': [1578, 3453, 3552], 'unable': [1583], 'DNA,': [1587], 'whereas': [1588, 1879], 'reduced': [1590], 'binds': [1592, 2055], 'strongly,': [1593], 'intramolecular': [1597], 'disulfide': [1598], 'bond': [1599], 'within': [1600], 'causes': [1606], 'interference': [1607], 'specific': [1609, 2061, 3167, 3179, 3192], '(37.Tell': [1612], 'Pellizzari': [1614, 1668, 1745, 1804, 3203, 3497], 'Cimarosti': [1616, 1806], 'Pucillo': [1618, 1678, 1755, 1808, 3213, 3507], 'Damante': [1620, 1676, 1753, 1810, 3211, 3505], 'Biochem.': [1622, 1812, 3050], 'Biophys.': [1623, 1813], 'Commun.': [1625, 1815], '1998;': [1626, 1816, 1952, 2332], '252:': [1627, 1817], '178-183Crossref': [1628, 1818], '(84)': [1631, 1821], 'exposure': [1635], 'H2O2': [1640], 'results': [1641], 'rapid': [1643], 'transfer': [1644], 'cytoplasmic': [1647, 2909], 'into': [1651, 3939, 3981, 4051, 4064], 'nucleus,': [1653], 'event': [1655], 'correlated': [1656], 'increase': [1659], '(33.Tell': [1664, 1741, 3199, 3493], 'Zecca': [1666, 1743, 3201, 3495], 'Spessotto': [1670, 1747, 3205, 3499], 'Colombatti': [1672, 1749, 3207, 3501], 'Kelley': [1674, 1751, 3209, 3503], 'Nucleic': [1680, 1757, 3215, 3509, 3871, 4152], 'Acids': [1681, 1758, 3216, 3510, 3872, 4153], '2000;': [1683, 1760, 3218, 3512], '28:': [1684, 1761, 3219, 3513], '1099-1105Crossref': [1685, 1762, 3220, 3514], '(99)': [1688, 1765, 3223, 3517], '(also': [1692], 'designated': [1693], 'HAP-1)': [1694], 'trifunctional': [1697], 'apurinic/apyrimidinic': [1701], 'endonuclease': [1702, 1881], 'base': [1704], 'repair': [1705, 1827], 'activity,': [1706, 3541], 'proofreading': [1708], 'exonuclease': [1709], '(34.Jiricny': [1711], 'Nature.': [1713], '415:': [1715], '593-594Crossref': [1716], '(21)': [1719], 'modulating': [1724], 'NF-κB,': [1733], 'Egr-1,': [1734], 'p53,': [1735], 'members': [1737], 'Pax': [1739], '35.Xanthoudakis': [1768], 'Miao': [1770, 1890], 'Pan': [1774], 'Y.C.': [1775], 'Curran': [1776, 1790, 1892], '3323-3335Crossref': [1782], '(826)': [1785], '36.Xanthoudakis': [1788], '653-665Crossref': [1796], '(602)': [1799], '37.Tell': [1802], 'activities': [1828], 'localized': [1832], 'distinct,': [1834], 'nonoverlapping': [1835], 'domains': [1836], 'independently.': [1842], 'N-terminal': [1844], 'contains': [1852, 2169, 3884, 4358], 'nuclear': [1854, 2947, 2976, 3573], 'localization': [1855], '(residues': [1857], '1–36)': [1858], '(38.Robbins': [1859], 'Dilworth': [1861], 'Laskey': [1863], 'R.A.': [1864], 'Dingwall': [1865], '64:': [1869], '615-623Abstract': [1870], '(1249)': [1876], 'resides': [1883], 'C-terminal': [1886], 'region': [1887, 2166, 3967], '(39.Xanthoudakis': [1888], 'G.G.': [1891], 'Proc.': [1894], 'Natl.': [1895], 'Acad.': [1896], 'Sci.': [1897], 'U.': [1898, 3864, 4147], '91:': [1902], '23-27Crossref': [1903], '(320)': [1906], 'expression': [1910, 1920, 4138, 4297, 4378], 'ubiquitous;': [1912], 'however,': [1913], 'exhibits': [1915], 'complex': [1917], 'heterogeneous': [1919], 'pattern': [1921], 'differs': [1923], 'among': [1924], 'tissue': [1925, 3714], 'types': [1926], '(40.Kakolyris': [1927], 'Kaklamanis': [1929], 'Giatromanolaki': [1931], 'Koukourakis': [1933], 'Hickson': [1935], 'I.D.': [1936], 'Barzilay': [1937], 'Turley': [1939], 'Leek': [1941], 'R.D.': [1942], 'Kanavaros': [1943], 'Georgoulias': [1945], 'V.': [1946], 'Gatter': [1947], 'K.C.': [1948], 'Harris': [1949], 'Histopathology.': [1951], '33:': [1953], '561-569Crossref': [1954], '(78)': [1957], 'Early': [1960], 'B-cell': [1961], 'was': [1963, 2016, 2210, 2222, 2475, 3161, 3419, 3488, 3660, 3664, 3704, 3722, 3754, 3766, 3799, 3825, 3831, 3921, 3937, 3979, 4287, 4341, 4405], 'lymphocyte-specific': [1968], 'recognizes': [1971, 2060], 'site': [1973, 3945, 3961, 3984, 4054, 4067, 4079], 'mb-1': [1976, 2233, 3375, 3445, 3547], '(41.Hagman': [1978, 2234], 'Travis': [1980, 1998, 2083, 2188, 2236, 2255], 'Grosschedl': [1982, 2002, 2087, 2105, 2152, 2192, 2238, 2259, 2277, 2294, 2345], '10:': [1987, 2243], '3409-3417Crossref': [1988, 2244], '(111)': [1991, 2247], '42.Hagman': [1994], 'Belanger': [1996, 2081, 2186, 2253], 'Turck': [2000, 2085, 2190, 2257], 'C.W.': [2001, 2086, 2191, 2258], '7:': [2007, 2092, 2197, 2264, 2298, 2349], '760-773Crossref': [2008, 2093, 2198, 2265], '(235)': [2011, 2096, 2201, 2268], 'This': [2014, 2395], 'olfactory': [2020, 2024], '1': [2022, 2690, 2742, 3004, 3117, 3155, 3246, 3360, 4314, 4474], 'neurons': [2025], '(43.Kudrycki': [2026], 'Stein-Izsak': [2028], 'Behn': [2030], 'Grillo': [2032], 'Akeson': [2034], 'Margolis': [2036], 'F.L.': [2037, 4424], '3002-3014Crossref': [2043], 'studies': [2051], 'showed': [2052], 'homodimer': [2058], 'nucleotide': [2062], 'representing': [2064], 'variations': [2065], 'inverted': [2068], 'repeat': [2069], '5′-GGGA(A/T)T': [2072], 'half-site': [2073], 'separated': [2074, 3410], '2': [2076, 2686, 2797, 2833, 3788, 4333], 'bp': [2077], 'spacer': [2078], '(42.Hagman': [2079, 2184, 2251], '44.Travis': [2099, 2271], 'Hagman': [2101, 2273], 'Hwang': [2103, 2275], '3392-4000Crossref': [2112, 2284], '(76)': [2115, 2287], 'mediated': [2122], 'zinc': [2126], 'coordination': [2127], 'motif': [2128], 'amino-terminal': [2131], 'half': [2132], 'there': [2136], 'mediate': [2141], 'DNA-dependent': [2142], 'dimerization': [2143, 2218], 'transactivation': [2145], '(45.Hagman': [2146], 'Gutch': [2148], 'Lin': [2150], '2907-2916Crossref': [2158], '(114)': [2161], 'COOH-terminal': [2165], 'second,': [2171], 'serine/threonine-rich': [2172], 'second': [2179], 'helix': [2180], 'basic-helix-loop-helix': [2182], 'proteins': [2183, 2409], 'deletion': [2205], 'α-helical': [2208], 'repeats': [2209], 'found': [2211], 'markedly': [2213], 'reduce': [2214], 'solution.': [2220], 'promoters': [2231], '46.Sigvardsson': [2290], "O'Riordan": [2292, 2343], '25-36Abstract': [2299, 2350], '(226)': [2307, 2358], '47.Martensson': [2310], 'Martensson': [2312], 'I.L.': [2313], '315-320Crossref': [2319], '48.Kee': [2325], 'B.L.': [2326], 'Murre': [2327], '188:': [2333], '699-713Crossref': [2334], '(212)': [2337], 'VpreB': [2340], '(46.Sigvardsson': [2341], 'B29': [2361], '(49.Akerblad': [2362], 'Rosberg': [2364], 'Leanderson': [2366], 'Sigvardsson': [2368, 2386], '19:': [2374], '392-401Crossref': [2375], '(55)': [2378], 'genes': [2383, 2407, 3679, 3854, 3908, 4142], '(50.Akerblad': [2384], '163:': [2391], '5453-5461PubMed': [2392], 'suggests': [2396], 'role': [2401, 2460, 2494, 2590, 3534], 'encoding': [2408, 3968], 'pre-B': [2412], 'receptor.': [2416], 'required': [2419], 'later': [2422], 'maintenance': [2430], 'characteristics': [2435], '(51.Horcher': [2438], 'Souabni': [2440], '779-790Abstract': [2447], '(198)': [2455], 'currently': [2468], 'aim': [2471], 'work': [2474], 'determine': [2477], 'whether': [2478], 'stimulation': [2480], 'investigate': [2492], 'process.': [2499], 'Our': [2500], 'data': [2501, 2586, 3684], 'Pax5a.': [2531, 3562], 'addition,': [2533], 'promoter.': [2551], 'observed': [2554], 'Together,': [2584], 'suggest': [2587], 'Cell': [2598, 2850], 'Preparation': [2599, 2848], 'Culture': [2601], 'Conditions—Purified': [2602], 'splenic': [2603], 'were': [2606, 2618, 2670, 2723, 2733, 2755, 2778, 2821, 2853, 2891, 2906, 2914, 2958, 2973, 2985, 3025, 3041, 3089, 3114, 3141, 3228, 3256, 3294, 3326, 3389, 3409, 3441, 3543, 3575, 3596, 3606, 3689, 3773, 3811, 3962, 3997, 4015, 4101, 4167, 4189, 4212, 4239, 4308, 4346, 4411, 4443, 4464, 4494], 'obtained': [2607, 3085, 3455], '6–12-week-old': [2609], 'female': [2610], 'Balb/c': [2611], 'follows:': [2614], 'splenocyte': [2615], 'suspension': [2617], 'depleted': [2619], 'red': [2621], 'blood': [2622], 'hypotonic': [2625], 'lysis': [2626, 2639, 2991, 4500], 'ACK': [2628], 'lysing': [2629], 'buffer': [2630, 2866, 2920, 2992, 3344, 3379, 3524, 4468, 4501], '(BioWhittaker)': [2631], 'complement-mediated': [2637], 'cytotoxic': [2638], 'using': [2640, 3043, 3104, 3258, 3971, 4191, 4219, 4466], 'anti-Thy': [2641], '1.2': [2642], 'mAb': [2643, 2739], '(a': [2644], 'gift': [2645], 'Hathcock,': [2648], 'Experimental': [2649], 'Immunology': [2650], 'Branch,': [2651], 'National': [2652], 'Cancer': [2653], 'Institute/National': [2654], 'Institutes': [2655], 'Health,': [2657], 'Bethesda,': [2658], 'MD)': [2659], 'conjunction': [2661], 'rabbit': [2663, 3165], 'complement': [2664], '(Low-Tox': [2665], 'M;': [2666], 'Cedar': [2667], 'Lane).': [2668], 'Cells': [2669, 4091], 'maintained': [2671, 3775, 4173], 'RPMI': [2673, 2824], '1640': [2674, 2825], 'supplemented': [2675, 2785, 2826, 3793], '10%': [2677, 2787, 2828], 'fetal': [2678, 2788, 2829, 3796], 'calf': [2679, 2789, 2830, 3363, 3797], '(Sigma),': [2681, 2791, 2832], '20': [2682, 2952, 3018, 3032, 3133], 'mm': [2683, 2687, 2691, 2711, 2798, 2834, 2869, 2874, 2877, 2880, 2883, 2887, 2923, 2928, 2931, 2934, 2939, 2943, 2994, 2999, 3002, 3005, 3011, 3346, 3351, 3354, 3357, 3382, 4470, 4475, 4478], 'Hepes': [2684], '(Invitrogen),': [2685, 2689, 2694, 2699, 2796, 2800, 2836], 'l-glutamine': [2688, 2799, 2835], 'sodium': [2692], 'pyruvate': [2693], '1%': [2695, 2792], 'non-essential': [2696, 2793], 'amino': [2697, 2794], 'acids': [2698, 2795], 'antibiotics': [2700, 2802, 2838], '(100': [2701, 2803, 3345], 'units/ml': [2702, 2804, 2840], 'penicillin,': [2703, 2805], '100': [2705, 2807, 2988, 3449, 3558, 3580], 'μg/ml': [2706, 2743, 2808, 2844, 4178], 'streptomycin)': [2707, 2809, 2845], '(BioWhittaker),': [2708], '50': [2710, 2862, 2917, 2998], 'β-mercaptoethanol': [2712], '(Sigma)': [2713, 3241, 4194], '37': [2715, 3781, 4349, 4415], '°C': [2716, 2902, 2969, 3153, 3782, 4350, 4416], '5%': [2718, 2936, 3125, 3413, 3777, 4352, 4418], 'CO2.': [2719, 4353], 'resulting': [2721, 3934], 'checked': [2724], 'cytofluorimetric': [2726], 'analysis': [2727, 3073], '(BD': [2728, 2744], 'Biosciences': [2729], 'FACScan)': [2730], 'then': [2732, 2859, 3229, 3422, 3698, 3738, 3774], 'incubated': [2734, 3142, 3234, 3327, 3447, 3576, 3730, 3755, 3812, 4347, 4413], 'purified': [2736, 3308, 3600], 'anti-mouse': [2737], 'HM40-3': [2740], 'Pharmingen)': [2745], '72': [2747], 'h.': [2748], 'All': [2749], 'experiments': [2750, 3436, 3522], 'reported': [2751], 'paper': [2754], 'performed': [2756, 3442, 3489, 3544], 'time': [2759], 'point,': [2760], 'represent': [2762], 'maximum': [2764], 'value': [2765], 'assayed': [2768], 'measuring': [2770], '[3H]thymidine': [2771], 'incorporation.': [2772], 'HeLa': [2773], '(human': [2774], 'cervical': [2775], 'carcinoma)': [2776], 'grown': [2779, 2822, 4102, 4320, 4449], "Dulbecco's": [2781], 'modified': [2782], "Eagle's": [2783], 'medium': [2784, 3792, 4175, 4340], '(BioWhittaker': [2810, 2846], 'Europe).': [2811, 2847], 'NS-1': [2812, 2981, 3481, 3568], '(non-secreting': [2813], 'myeloma)': [2815], 'Raji': [2817], '(Burkitt': [2818], 'lymphoma)': [2819], '(200': [2839], 'penicillin': [2841], '200': [2843, 3725, 3747], 'Extracts—107': [2851], 'washed': [2854, 3230, 3690, 4444], 'twice': [2855, 4445], 'PBS': [2857, 4447], 'resuspended': [2860, 2915, 4495], 'μl': [2863, 2918, 2989, 3718, 3726, 3748, 3765, 4498], 'ice-cold': [2865], 'A': [2867, 4276], '(10': [2868, 2993, 3743], 'Hepes,': [2870, 2924], 'pH': [2871, 2925, 2996, 3348, 4472], '7.9,': [2872, 2926], '10': [2873, 2898, 3353, 3356, 3391, 3474], 'KCl,': [2875, 3352], '1.5': [2876, 2930], 'MgCl2,': [2878, 2932], '0.1': [2879, 2933], 'EDTA,': [2881, 2935, 3355, 4476], '0.5': [2882, 2886, 2938, 2942, 3010], 'phenylmethylsulfonyl': [2884, 2940, 3012], 'fluoride,': [2885, 2941], 'DTT).': [2888], 'samples': [2890, 2957, 3061, 3408], 'centrifuged': [2892, 2959, 3026, 4480], '800': [2894], '×': [2895, 2962, 3029, 3708, 3809, 4315, 4483], 'g': [2896, 2963, 3030, 4484], 'min': [2899, 2953, 2966, 3019, 3033, 3338, 3392, 3733, 3758, 4487], '4': [2901, 2968, 3021, 3152, 3707, 4182, 4489], 'supernatants': [2905, 2972], 'collected': [2907, 2974], 'extracts.': [2910, 2977, 3483], 'Then,': [2911], 'pellets': [2913, 4493], '(20': [2922], '400': [2927, 3466, 3764], 'NaCl,': [2929, 3003], 'glycerol,': [2937], 'DTT)': [2944, 3358], 'extract': [2946], 'proteins.': [2948], 'After': [2949, 3135, 3251, 4163, 4181, 4459], 'incubation': [2950, 3016, 3300], 'ice,': [2955], '10,000': [2961], '30': [2965, 3337, 3732, 4186], 'For': [2978, 3433], 'whole': [2979], 'extracts,': [2982], '107': [2983], 're-suspended': [2986], 'Tris-HCl,': [2995, 3347, 4471], '7.5,': [2997], 'NaF,': [3000], '150': [3001, 3350, 4477, 4497], '0.5%': [3007], 'Nonidet': [3008], 'P-40,': [3009], 'fluoride)': [3013], 'and,': [3014], 'after': [3015, 3456, 3786], '°C,': [3022, 4490], 'extracts': [3024, 3323, 3574], '22,000': [3028], 'remove': [3035], 'debris.': [3038], 'Protein': [3039], 'concentrations': [3040], 'determined': [3042, 3826], 'Bradford': [3045], 'method': [3046], '(52.Bradford': [3047], 'M.M.': [3048], 'Anal.': [3049], '1976;': [3051], '72:': [3052], '248-254Crossref': [3053], '(217544)': [3056], 'immediately': [3063], 'Western': [3065, 3079], 'blot': [3066], 'assay': [3071], '(EMSA)': [3072], 'kept': [3075], '–80': [3077, 3431], '°C.': [3078, 3432], 'Blot': [3080], 'Analysis—Equal': [3081], 'amounts': [3082, 3550], 'protein,': [3084, 3454], 'described': [3087, 3491], 'above,': [3088], 'electrophoresed': [3090], '12%': [3093], 'SDS-PAGE': [3094], 'minigel': [3095], 'transferred': [3097, 4168], 'nitrocellulose': [3099], 'membranes': [3100, 3140], '(Schleicher': [3101], '&': [3102], 'Schuell)': [3103], 'semidry': [3106], 'apparatus': [3107], '(Multiphor': [3108], 'II,': [3109], 'Amersham': [3110], 'Biosciences).': [3111, 3321], 'filters': [3113, 3227], 'blocked': [3115], 'h': [3118, 3156, 3247, 4334, 4422, 4461], 'room': [3120, 3158, 3249, 3340, 3735], 'temperature': [3121, 3341], 'blocking': [3123, 3148, 3243], 'solution:': [3124], 'nonfat': [3126], 'milk': [3127], 'powder': [3128], '0.05%': [3131], 'Tween': [3132], '(PBST).': [3134], 'washing': [3136, 3252], 'PBST,': [3138], 'primary': [3144], 'Ab': [3145], '(diluted': [3146], 'solution)': [3149], 'overnight': [3150], 'temperature.': [3159, 3250], 'detected': [3162], 'polyclonal': [3166, 3178, 3191], '(Santa': [3169], 'Cruz': [3170], 'Biotechnology),': [3171], 'actin': [3172], 'nucleoporin': [3174], '(Sigma': [3181], 'BD': [3183], 'Biosciences,': [3184], 'respectively),': [3185], 'D2A8': [3194], 'generated': [3195], 'our': [3197], 'laboratory': [3198], 'PBST': [3232], 'horseradish': [3237], 'peroxidase-conjugated': [3238], 'secondary': [3239], 'antibodies': [3240], 'solution': [3244], 'immunoreactive': [3254], 'bands': [3255], 'visualized': [3257], 'chemiluminescence': [3260], 'substrate': [3261], '(Pierce)': [3262], 'Bio-Max': [3264], 'light': [3265], 'films': [3266], '(Kodak)': [3267], 'according': [3268, 3680], "manufacturer's": [3271], 'protocol.': [3272], 'EMSA—The': [3273], 'top': [3277], 'strand': [3278], 'double-stranded': [3280], 'oligonucleotide': [3281, 3590, 3595], 'probes': [3282], 'EMSAs': [3285], 'were:': [3286], 'H2A2.2,': [3287], '5′-TCTGACGCAGCGGTGGGTGACGACT;': [3288], '5′-GAGAGAGACTCAAGGGAATTGTGG;': [3290], 'CREB,': [3291], '5′-AGAGATTGCCTGACGTCAGAGAGCTAG.': [3292], 'Oligonucleotides': [3293], 'end': [3295, 3819], 'labeled': [3296, 3332], '[γ-32P]dATP': [3298], 'T4': [3302], 'polynucleotide': [3303], '(Fermentas),': [3305], 'annealed,': [3306], 'column': [3310], 'spinX': [3311], 'Costar': [3312], '8160': [3313], '(Corning)': [3314], 'filled': [3315, 3928, 3943], 'Sephadex': [3317], 'G-50': [3318], 'fine': [3319], '(Amersham': [3320, 3427], 'Nuclear': [3322], '(8': [3324], 'μg)': [3325, 3744], '0.5–1': [3329], 'ng': [3330, 3450, 3467, 3559, 3581], 'probe': [3333, 3398, 3446, 3659, 3671], '(10,000–20,000': [3334], 'cpm)': [3335], '7.4,': [3349, 4473], 'μg': [3361, 3475, 3565, 4118, 4360, 4367, 4371, 4375], 'thymus': [3364], 'bovine': [3366], 'albumin.': [3368], 'EMSA': [3371, 3440, 3542], 'experiment': [3372], 'probe,': [3376, 3548], 'contained': [3380], '0.2': [3381, 4374], 'ZnCl2.': [3383], 'Unlabeled': [3384], 'oligonucleotides': [3385, 3605], 'competitors': [3388], 'added': [3390, 3705, 3767, 3800, 4406], 'before': [3393, 3492], 'molar': [3400], 'excesses': [3401], 'indicated': [3402], 'respective': [3405], 'figures.': [3406], 'polyacrylamide': [3414], 'Tris': [3415], 'borate-EDTA': [3416], 'gel,': [3417], 'dried': [3420], 'exposed': [3423], 'Hyperfilm-MP': [3426], 'Biosciences)': [3428], 'film': [3429], 'vitro': [3435], 'recombinant': [3438, 3470, 3555, 3561], 'proteins,': [3439], 'GST-EBF': [3452, 3553], 'prolonged': [3457], 'air': [3458], 'exposure,': [3459], 'presence': [3462, 3893, 4204, 4323, 4452], 'absence': [3464, 4325, 4454], 'crude,': [3477], 'boiled,': [3478], 'APE/Ref-1-depleted': [3480], 'cellular': [3482], 'immunoprecipitation': [3485], 'did': [3525, 3672], 'contain': [3527], 'EDTA': [3528], 'DTT.': [3530], 'To': [3531], 'test': [3532], 'equal': [3549], 'APE/Ref-1,': [3556], '3': [3564], 'stable': [3567], 'transfected': [3569, 3806, 4110], '(NS-1/Pax5a)': [3572], 'without': [3579], 'GST-EBF.': [3583], 'Oligonucleotide': [3584], 'Treatment': [3585], 'Cells—APE/Ref-1': [3588], 'antisense': [3589, 3658], 'complementary': [3593], 'sense': [3594, 3663], 'synthesized': [3597], 'HPSF': [3599], 'MWG-Biotech': [3602], 'AG.': [3603], 'phosphorothioated': [3607], '3′': [3609], '5′': [3611], 'ends': [3612], '(at': [3613], 'position': [3615], 'marked': [3616], '*)': [3618], 'confer': [3620], 'nuclease': [3621], 'resistance': [3622], '(53.Daily': [3623], 'Vlamis-Gardikas': [3625], 'Offen': [3627], 'Mittelman': [3629], 'Melamed': [3631], 'E.': [3632], 'Holmgren': [3633], 'Barzilai': [3635], '276:': [3641], '1335-1344Abstract': [3642], '5′-T*T*CCCCGCTTTGGCATC*G*C*-3′,': [3661], '5′-G*C*GATGCCAAAGCGGGG*A*A*-3′': [3665], '(nucleotides': [3666], '–3': [3667], '16).': [3669], 'other': [3677], 'known': [3678], 'GenBank™': [3683], 'base.': [3685], 'Spleen': [3686], 'once': [3691], 'serum-free': [3693, 3702, 3728, 3750], 'media': [3694, 3703], '(Opti-MEM,': [3695], 'Invitrogen)': [3696], '1.6': [3699], 'ml': [3700, 3789], '106': [3709], '60-mm': [3713], 'culture': [3715, 3823, 4339], 'plate.': [3716], '25': [3717], 'Lipofectin': [3720], '(Invitrogen)': [3721], 'diluted': [3723, 3745], 'media,': [3729], 'temperature,': [3736], 'mixed': [3739], 'media.': [3751], 'mixture': [3753], '15': [3757], 'combined': [3761], 'volume': [3762], 'CO2': [3778, 4419], 'incubator': [3779], '12': [3784], 'h,': [3785, 4165], 'growth': [3791, 3824], '20%': [3795], 'transfection': [3803, 4385], 'well.': [3804], 'Then': [3805], '(1': [3808], '106/ml)': [3810], 'appropriate': [3815, 4234], 'stimulus.': [3816], 'At': [3817], 'incubation,': [3822], 'counting,': [3828], 'viability': [3830], 'confirmed': [3832, 3992, 4213], 'trypan': [3834], 'blue': [3835], 'exclusion.': [3836], 'Plasmids': [3837], 'Construction': [3839], 'Bidirectional': [3842], 'Expression': [3843], 'Vector—': [3844], 'pBI': [3846, 3947, 3986, 4056, 4140], 'vector': [3847, 4247, 4379], '(Clontech)': [3848, 3898, 4121], 'allows': [3849, 3899], 'simultaneously': [3851], 'express': [3852, 4128], 'under': [3855], 'bidirectional': [3859], 'tetracycline-responsive': [3860], '(Pbi-1)': [3862], '(54.Baron': [3863], 'Freundlieb': [3865], 'Gossen': [3867, 4148], 'Bujard': [3869, 4150], '23:': [3875], '3605-3606Crossref': [3876], '(270)': [3879], 'Pbi-1': [3882, 4134], 'Tet-responsive': [3886, 3912], 'element,': [3887], 'repressed': [3890], 'tetracycline': [3895], '(Tc).': [3896], 'pBI-GL': [3897], 'simultaneous': [3901], 'luciferase': [3905, 4267], 'β-galactosidase': [3907, 4269], 'central': [3911], 'element.': [3913], '965-bp': [3915], 'BamHI/EcoRI': [3916], 'fragment': [3917, 3936], 'containing': [3918, 3957, 4009, 4176], 'hRef-1': [3919], 'cDNA': [3920], 'taken': [3922, 4016], 'pGEX-3X-hRef-1': [3924], '(see': [3925], 'below)': [3926], 'Klenow': [3931, 3942], 'fragment.': [3932], 'blunt': [3935], 'cloned': [3938, 3980, 4050, 4063, 4141], 'NheI': [3941, 3959, 3983], 'make': [3949, 3988, 4058, 4071, 4083], 'pBI-APE/Ref-1.': [3950], 'Primers': [3951], 'EBF-NheI-REV': [3952], '(5′-GCAGCTAGCCACTCTGGGACTCATG-3′)': [3953], 'EBF-NheI-FOR': [3955], '(5′-GTAGCTAGCTGGGCAGCGGCATGAA-3′)': [3956], 'restriction': [3960], 'amplify': [3965, 4229], 'cDNA,': [3970, 4013], 'CMV-EBF': [3972], 'template.': [3975], 'amplified': [3977], 'pBI-EBF.': [3989], 'sequencing': [3991], 'PCR': [3995, 4215], 'products': [3996], 'free': [3998], 'any': [4000], 'undesired': [4001], 'mutations.': [4002], '1.2-kb': [4004], '750-bp': [4006], 'NotI': [4007, 4053, 4066, 4078], 'fragments': [4008], 'respectively,': [4014, 4075], 'pcDNA3.1-Pax5a': [4018], 'pcDNA3.1-Pax5d': [4020], 'pBI-Pax5a': [4059], 'pBI-Pax5d': [4061], 'pBI-EBF': [4069], 'pBI-Pax5a-EBF': [4072], 'pBI-Pax5d-EBF,': [4074], 'PBI-Ref-1': [4081], 'pBI-Pax5a-APE/Ref-1': [4084], 'pBI-Pax5d-APE/Ref-1,': [4086], 'respectively.': [4087], 'Generation': [4088], 'Stable': [4090], 'Expressing': [4092], 'Various': [4093], 'Transactivators': [4094], 'Quantification': [4096], 'Transactivation': [4098], 'Activity—HeLa': [4099], '35-mm': [4104], 'dishes': [4105, 4171], '50–60%': [4107], 'confluence': [4108], 'via': [4111], 'calcium': [4113, 4355], 'phosphate': [4114], 'procedure': [4115], '5': [4117, 4486], 'tTA2/3/4': [4120], 'plasmids.': [4122], 'These': [4123], 'three': [4125], 'vectors': [4126], 'different': [4130, 4144], 'levels': [4131, 4145], 'tetracycline-sensitive': [4133], 'transactivator': [4135], 'cause': [4137], '(55.Baron': [4146], '25:': [4156], '2723-2729Crossref': [4157], '(291)': [4160], '24': [4164, 4421], '10-cm': [4170], '500': [4177], 'G418': [4179], '(Invitrogen).': [4180], 'weeks,': [4183], 'least': [4185], 'resistant': [4187], 'clones': [4188, 4238, 4251], 'isolated': [4190], 'cloning': [4192], 'cylinders': [4193], 'expanded': [4195], 'separately': [4196], 'frozen': [4198], 'soon': [4200], 'possible.': [4202], 'integrated': [4206], 'tTA': [4207, 4235], 'neomycin-resistant': [4209], 'lines': [4211], 'chromosomal': [4217], 'primers': [4220], 'ptTA': [4221, 4225], 'forward': [4222], '(5′-GTCTGGATCCTTACTTAGTTACCC-3′)': [4223], 'reverse': [4226], '(5′-ATAGAAGACACCGGGACCGATC-3′)': [4227], 'portion': [4231], 'plasmid.': [4236], 'Positive': [4237], 'screened': [4240], 'transient': [4242], 'transfections': [4243], 'PBI-GL': [4245], 'reporter': [4246], 'identify': [4249], 'G418-resistant': [4250], 'meet': [4253], 'criteria': [4255], 'good': [4257], 'Tet-Off': [4258], 'lines:': [4260], 'low': [4261], 'background': [4262], 'high': [4264], 'induction': [4265, 4293], 'Tc': [4273, 4327, 4456], '(2': [4274, 4328, 4457], 'μg/ml).': [4275, 4329, 4458], 'clone': [4277], 'HeLa-tTA2': [4279, 4306, 4408], '(HeLa': [4281], 'synthesize': [4285], 'tTA2)': [4286], 'selected': [4288], 'highest': [4291, 4296], '-fold': [4292], '(e.g.': [4294], 'showing': [4295], 'lowest': [4299], 'background)': [4300], 'propagation': [4302], 'further': [4304, 4412], 'testing.': [4305], 'seeded': [4309], 'density': [4312], '105': [4316], 'cell/35-mm': [4317], 'dish': [4318], 'next': [4331, 4439], 'day,': [4332, 4440], 'prior': [4335], 'transfection,': [4337], 'renewed': [4342], 'phosphate/DNA': [4356], 'precipitate': [4357, 4402], '2.5': [4359], 'plasmid': [4362], '(consisting': [4364], '0.6': [4366], 'pBI,': [4369], '0.8': [4370], 'pGLblk,': [4373], 'lacZ': [4377], '(CMV-β-galactosidase),': [4380], 'included': [4381], 'normalization': [4383], 'efficiency,': [4386], 'pUC18': [4388], 'nonspecific': [4390], 'carrier': [4391], 'equalization': [4394], 'content': [4397], 'transfection).': [4400], '(55': [4403], 'μl/dish)': [4404], '(56.Graham': [4423], 'van': [4425], 'der': [4426], 'Eb': [4427], 'A.J.': [4428], 'Virology.': [4429], '1973;': [4430], '54:': [4431], '536-539Crossref': [4432], '(419)': [4435], '48': [4460], 'scraped': [4465], 'TEN': [4467], '(40': [4469], 'NaCl),': [4479], '300': [4482], 'provided': [4502]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2027498615', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T11:49:22.751358', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
