Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2027478967', 'doi': 'https://doi.org/10.1074/jbc.m605573200', 'title': 'Enzymatically Active Mammalian Ribonucleotide Reductase Exists Primarily as an α6β2 Octamer', 'display_name': 'Enzymatically Active Mammalian Ribonucleotide Reductase Exists Primarily as an α6β2 Octamer', 'publication_year': 2006, 'publication_date': '2006-07-23', 'ids': {'openalex': 'https://openalex.org/W2027478967', 'doi': 'https://doi.org/10.1074/jbc.m605573200', 'mag': '2027478967', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16861739'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605573200', 'pdf_url': 'http://www.jbc.org/article/S0021925819580553/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819580553/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023042261', 'display_name': 'Reza Rofougaran', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90267481', 'display_name': 'Umeå University', 'ror': 'https://ror.org/05kb8h459', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I90267481']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Reza Rofougaran', 'raw_affiliation_strings': ['Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden', 'institution_ids': ['https://openalex.org/I90267481']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087542228', 'display_name': 'Munender Vodnala', 'orcid': 'https://orcid.org/0000-0002-6219-6243'}, 'institutions': [{'id': 'https://openalex.org/I90267481', 'display_name': 'Umeå University', 'ror': 'https://ror.org/05kb8h459', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I90267481']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Munender Vodnala', 'raw_affiliation_strings': ['Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden', 'institution_ids': ['https://openalex.org/I90267481']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088560384', 'display_name': 'Anders Hofer', 'orcid': 'https://orcid.org/0000-0003-2890-2957'}, 'institutions': [{'id': 'https://openalex.org/I90267481', 'display_name': 'Umeå University', 'ror': 'https://ror.org/05kb8h459', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I90267481']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Anders Hofer', 'raw_affiliation_strings': ['Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden', 'institution_ids': ['https://openalex.org/I90267481']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.111, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 103, 'citation_normalized_percentile': {'value': 0.956711, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '281', 'issue': '38', 'first_page': '27705', 'last_page': '27711'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11747', 'display_name': 'Metal-Catalyzed Oxygenation Mechanisms', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11747', 'display_name': 'Metal-Catalyzed Oxygenation Mechanisms', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10683', 'display_name': 'Mass Spectrometry Techniques and Applications', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribonucleotide-reductase', 'display_name': 'Ribonucleotide reductase', 'score': 0.9608712}, {'id': 'https://openalex.org/keywords/ribonucleotide', 'display_name': 'Ribonucleotide', 'score': 0.76403046}, {'id': 'https://openalex.org/keywords/deoxyribonucleotides', 'display_name': 'Deoxyribonucleotides', 'score': 0.6991122}], 'concepts': [{'id': 'https://openalex.org/C4710235', 'wikidata': 'https://www.wikidata.org/wiki/Q420089', 'display_name': 'Ribonucleotide reductase', 'level': 4, 'score': 0.9608712}, {'id': 'https://openalex.org/C98892162', 'wikidata': 'https://www.wikidata.org/wiki/Q422484', 'display_name': 'Ribonucleotide', 'level': 4, 'score': 0.76403046}, {'id': 'https://openalex.org/C2910443878', 'wikidata': 'https://www.wikidata.org/wiki/Q28751', 'display_name': 'Deoxyribonucleotides', 'level': 4, 'score': 0.6991122}, {'id': 'https://openalex.org/C512185932', 'wikidata': 'https://www.wikidata.org/wiki/Q28745', 'display_name': 'Nucleotide', 'level': 3, 'score': 0.6302439}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6192285}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.57700056}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.53140527}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50594634}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.4719224}, {'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.41282535}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.35812417}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32326743}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.17596647}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020836', 'descriptor_name': 'Protein Structure, Quaternary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012264', 'descriptor_name': 'Ribonucleotide Reductases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002850', 'descriptor_name': 'Chromatography, Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004586', 'descriptor_name': 'Electrophoresis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012264', 'descriptor_name': 'Ribonucleotide Reductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012264', 'descriptor_name': 'Ribonucleotide Reductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605573200', 'pdf_url': 'http://www.jbc.org/article/S0021925819580553/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16861739', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605573200', 'pdf_url': 'http://www.jbc.org/article/S0021925819580553/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1481281898', 'https://openalex.org/W153095713', 'https://openalex.org/W1553542366', 'https://openalex.org/W1591225233', 'https://openalex.org/W1592511703', 'https://openalex.org/W1963876890', 'https://openalex.org/W1966538841', 'https://openalex.org/W1966985858', 'https://openalex.org/W1974981534', 'https://openalex.org/W1976650039', 'https://openalex.org/W1986329003', 'https://openalex.org/W1988043430', 'https://openalex.org/W1998032255', 'https://openalex.org/W2012914676', 'https://openalex.org/W2014264653', 'https://openalex.org/W2017731713', 'https://openalex.org/W2031603364', 'https://openalex.org/W2044381712', 'https://openalex.org/W2045074917', 'https://openalex.org/W2046237091', 'https://openalex.org/W2051974567', 'https://openalex.org/W2060455152', 'https://openalex.org/W2094524049', 'https://openalex.org/W2108990704', 'https://openalex.org/W4256321774'], 'related_works': ['https://openalex.org/W637451652', 'https://openalex.org/W4255149326', 'https://openalex.org/W2618533933', 'https://openalex.org/W2467707097', 'https://openalex.org/W2084086913', 'https://openalex.org/W2033743916', 'https://openalex.org/W1712290172', 'https://openalex.org/W1569699813', 'https://openalex.org/W1564559265', 'https://openalex.org/W146779788'], 'abstract_inverted_index': {'Ribonucleotide': [0, 153, 306, 2067], 'reductase': [1, 15, 144, 154, 168, 297, 307, 346, 1069, 1275, 1562, 3011, 4738, 4898, 5606, 5839, 5911, 6219], 'synthesizes': [2, 155], 'deoxyribonucleotides,': [3, 156], 'which': [4, 157, 355, 532, 704, 1202, 2882, 3440, 3472, 3810, 3854, 3950, 4270, 4632, 5331], 'are': [5, 158, 356, 383, 416, 828, 1085, 1254, 1263, 1391, 1437, 1625, 3952, 5681, 5894, 5912, 6045], 'essential': [6, 159], 'building': [7, 160, 323], 'blocks': [8, 161, 324], 'for': [9, 162, 325, 386, 686, 707, 833, 2012, 2135, 2173, 2364, 2393, 2400, 2564, 2576, 3159, 3501, 3580, 3802, 4087, 4422, 4531, 4842, 5066, 5125, 5466, 5484, 5600, 5719, 6330, 6354], 'DNA': [10, 163, 326], 'synthesis.': [11, 164], 'The': [12, 108, 165, 261, 343, 389, 435, 528, 591, 694, 758, 787, 845, 913, 1162, 1379, 1593, 1638, 1679, 1734, 1779, 1845, 1936, 1957, 1976, 2015, 2125, 2208, 2404, 2452, 2529, 2553, 2581, 2631, 2659, 2672, 2744, 3035, 3062, 3230, 3249, 3295, 3309, 3413, 3428, 3449, 3484, 3519, 3544, 3587, 3685, 3703, 3899, 3986, 4070, 4134, 4255, 4283, 4383, 4464, 4576, 4596, 4643, 4682, 4852, 4966, 5105, 5133, 5285, 5480, 5499, 5781, 5836, 6037, 6265, 6300], 'mammalian': [13, 166, 344, 479, 1273, 4736, 5837], 'ribonucleotide': [14, 143, 167, 296, 345, 1068, 1274, 1561, 3010, 4737, 4897, 5605, 5838, 5847, 5910, 6218, 6316], 'is': [16, 129, 138, 169, 282, 291, 308, 392, 407, 482, 534, 546, 598, 621, 633, 683, 705, 761, 807, 842, 849, 910, 920, 1080, 1116, 1197, 1220, 1238, 1306, 1324, 1415, 1494, 2183, 3131, 3203, 3267, 3378, 3494, 3563, 3636, 4068, 4085, 4112, 4669, 4808, 5018, 5122, 5138, 5179, 5190, 5349, 5362, 5442, 5454, 5459, 5685, 5884, 5928, 6212, 6228, 6295], 'described': [17, 170, 1702, 1758], 'as': [18, 171, 322, 715, 884, 1074, 1701, 1740, 1757, 2177, 2230, 2247, 2449, 2484, 3226, 3615, 3727, 3813, 4454, 4782, 4840, 5023, 5165, 5257, 5261, 5744, 5900, 6023, 6025], 'an': [19, 40, 102, 117, 120, 172, 193, 255, 270, 273, 412, 502, 720, 728, 795, 1158, 1449, 1603, 1655, 2735, 3292, 3564, 4322, 4376, 4650, 4846, 4916, 5078, 5129, 5308, 6121], 'α2β2': [20, 173, 505, 1225, 1606, 4377, 5309, 5339, 6122], 'complex': [21, 106, 112, 137, 174, 259, 265, 290, 506, 1640, 2718, 2866, 2897, 2929, 3841, 4111, 4261, 4466, 4647, 4686, 5310, 5354, 5383, 5386, 5699, 5883, 5899, 5935, 5978, 6211], 'consisting': [22, 175, 2317, 2990], 'of': [23, 66, 142, 148, 176, 219, 295, 301, 317, 372, 475, 501, 584, 625, 642, 701, 713, 789, 847, 940, 995, 1097, 1176, 1206, 1224, 1424, 1451, 1488, 1543, 1559, 1590, 1612, 1651, 1661, 1742, 1793, 1848, 1919, 1954, 1969, 2018, 2035, 2090, 2141, 2210, 2219, 2224, 2245, 2304, 2309, 2318, 2340, 2345, 2412, 2431, 2438, 2543, 2561, 2571, 2589, 2601, 2629, 2674, 2714, 2716, 2730, 2739, 2746, 2778, 2845, 2855, 2864, 2870, 2933, 2947, 2954, 2991, 3018, 3037, 3040, 3044, 3064, 3084, 3098, 3106, 3124, 3136, 3173, 3241, 3259, 3276, 3316, 3338, 3360, 3384, 3401, 3432, 3446, 3476, 3481, 3486, 3492, 3504, 3535, 3558, 3585, 3593, 3623, 3656, 3671, 3687, 3705, 3819, 3829, 3846, 3849, 3879, 3889, 3957, 3981, 3988, 4090, 4137, 4144, 4158, 4175, 4183, 4201, 4214, 4226, 4257, 4301, 4346, 4369, 4405, 4507, 4556, 4578, 4587, 4615, 4645, 4684, 4693, 4706, 4713, 4725, 4845, 4902, 4907, 4911, 4919, 4968, 5008, 5038, 5047, 5098, 5107, 5128, 5135, 5149, 5161, 5184, 5195, 5267, 5293, 5317, 5326, 5358, 5378, 5397, 5425, 5469, 5491, 5508, 5541, 5604, 5671, 5679, 5691, 5741, 5765, 5793, 5831, 5846, 5939, 6028, 6217, 6250, 6302, 6315, 6340], 'R1': [24, 49, 67, 86, 177, 202, 220, 239, 377, 428, 436, 480, 509, 604, 628, 649, 680, 930, 988, 1106, 1154, 1177, 1207, 1252, 1591, 1594, 1623, 1665, 1680, 1780, 1850, 1921, 1923, 1958, 2020, 2074, 2220, 2305, 2373, 2402, 2707, 2736, 2846, 2858, 2928, 2937, 3005, 3046, 3100, 3187, 3231, 3250, 3356, 3394, 3421, 3423, 3426, 3447, 3470, 3551, 3625, 3660, 3698, 3804, 3840, 3855, 3881, 3942, 4091, 4116, 4139, 4168, 4311, 4329, 4338, 4597, 4639, 4680, 5296, 5327, 5385, 5426, 5438, 5493, 5510, 5529, 5543, 5673, 5692, 5742, 6059, 6292, 6342], '(α)': [25, 178, 378], 'and': [26, 32, 57, 93, 151, 179, 185, 210, 246, 304, 367, 379, 399, 409, 422, 442, 450, 455, 464, 512, 555, 565, 614, 765, 839, 890, 893, 905, 981, 1077, 1087, 1215, 1269, 1401, 1420, 1435, 1567, 1621, 1692, 1698, 1748, 1754, 1781, 1818, 1851, 1951, 1988, 2061, 2079, 2082, 2117, 2138, 2195, 2202, 2221, 2249, 2306, 2337, 2359, 2397, 2428, 2470, 2540, 2567, 2594, 2654, 2690, 2734, 2848, 2889, 2921, 2951, 2962, 2998, 3022, 3088, 3141, 3192, 3211, 3232, 3247, 3291, 3409, 3425, 3596, 3626, 3646, 3668, 3757, 3823, 3834, 3867, 3893, 4021, 4076, 4148, 4185, 4239, 4287, 4303, 4339, 4387, 4481, 4565, 4569, 4624, 4723, 4821, 4915, 4948, 5025, 5059, 5120, 5208, 5245, 5259, 5319, 5329, 5340, 5356, 5410, 5513, 5530, 5544, 5557, 5589, 5649, 5725, 5768, 5824, 5856, 6041, 6110, 6166, 6194, 6234, 6284, 6324, 6337, 6343], 'R2': [27, 98, 180, 251, 380, 390, 1062, 1160, 1181, 1236, 1600, 1633, 1736, 1744, 1782, 1852, 2083, 2225, 2310, 2395, 3057, 3194, 3233, 3278, 3627, 4319, 4336, 4340, 4407, 4475, 4509, 4558, 4588, 4609, 4617, 4630, 4667, 4674, 4695, 4708, 4716, 5305, 5335, 5497, 5514, 5533, 5545, 5703, 6118, 6344], '(β)': [28, 181, 381], 'proteins.': [29, 182, 6345], 'ATP': [30, 56, 126, 183, 209, 279, 454, 539, 764, 790, 832, 1000, 1268, 1613, 1652, 2246, 2851, 2888, 2950, 3982, 3996, 4058, 4780, 4807, 4836, 4920, 4976, 5032, 5108, 5144, 5150, 5185, 5275, 5318, 5662, 5680, 5734, 5757, 5794, 5832, 6139, 6185, 6235], 'stimulates': [31, 184, 562, 567, 1203], 'dATP': [33, 58, 128, 186, 211, 281, 456, 541, 766, 830, 848, 1002, 1270, 1615, 2849, 2890, 3071, 3708, 3866, 3896, 3900, 4060, 4102, 4302, 4579, 5660, 5736, 5940, 6251], 'inhibits': [34, 187, 4789], 'enzyme': [35, 60, 188, 213, 311, 370, 552, 575, 797, 841, 908, 2175, 2981, 3082, 3108, 3128, 3758, 4459, 4732, 4823, 4831, 4856, 4867, 5017, 5048, 5094, 5110, 5136, 5156, 5246, 5268, 5359, 5590, 5826, 5927, 6022, 6182], 'activity': [36, 45, 189, 198, 451, 695, 700, 760, 770, 798, 837, 909, 917, 942, 997, 3012, 3028, 3043, 3097, 3129, 3161, 3759, 3861, 4064, 4453, 4733, 4802, 4824, 4832, 4857, 5027, 5095, 5111, 5117, 5137, 5157, 5188, 5269, 5451, 5591, 5647, 5666, 6171, 6183, 6243, 6255, 6312], 'by': [37, 55, 190, 208, 411, 507, 763, 1256, 1330, 1404, 1563, 1694, 1750, 1786, 2024, 2256, 2354, 2378, 2486, 2518, 2549, 2685, 2696, 2720, 2968, 3301, 3581, 3872, 4024, 4101, 4120, 4293, 4350, 4728, 4943, 5116, 5211, 5403, 5746, 5787, 5798, 6256], 'binding': [38, 191, 641, 767, 788, 834, 1156, 1175, 3731, 4300, 4705, 4712, 4977, 6249], 'to': [39, 100, 192, 253, 312, 350, 362, 458, 467, 491, 535, 548, 623, 646, 691, 727, 768, 791, 835, 901, 1118, 1152, 1157, 1179, 1265, 1311, 1394, 1410, 1439, 1484, 1583, 1863, 1966, 1980, 1995, 2029, 2168, 2409, 2434, 2526, 2534, 2751, 2766, 2775, 2867, 2878, 2911, 2973, 3002, 3026, 3076, 3110, 3133, 3149, 3154, 3169, 3175, 3215, 3365, 3370, 3468, 3691, 3716, 3905, 3908, 4062, 4191, 4222, 4264, 4315, 4333, 4375, 4469, 4486, 4528, 4602, 4635, 4649, 4678, 4742, 4798, 4800, 4816, 4860, 4974, 4978, 5062, 5153, 5186, 5278, 5337, 5374, 5417, 5432, 5449, 5461, 5463, 5477, 5554, 5664, 5763, 5841, 5886, 5896, 5930, 5975, 6017, 6147, 6274, 6276, 6297], 'allosteric': [41, 194, 444, 460, 612, 903, 1617, 2732, 2759, 3104, 3242, 3657, 3693, 3724, 3850, 4028, 4745, 4871, 4895, 5215, 5392, 5434, 5474, 5602, 5641], 'site': [42, 46, 195, 199, 425, 441, 494, 530, 596, 619, 689, 696, 771, 793, 806, 838, 888, 918, 943, 998, 1586, 2755, 3674, 3720, 3862, 3870, 3913, 4004, 4421, 4786, 4803, 4819, 4849, 4981, 5118, 5189, 5198, 5420, 5465, 5653, 5657, 6056, 6313], 'called': [43, 196, 376], 'the': [44, 48, 52, 84, 97, 139, 197, 201, 205, 237, 250, 292, 318, 351, 360, 419, 423, 427, 431, 448, 469, 473, 478, 492, 499, 551, 574, 589, 594, 603, 626, 643, 647, 687, 698, 702, 709, 723, 769, 804, 836, 840, 907, 916, 938, 941, 987, 993, 996, 1061, 1082, 1111, 1114, 1174, 1180, 1204, 1221, 1235, 1251, 1257, 1272, 1327, 1422, 1425, 1429, 1442, 1492, 1521, 1533, 1540, 1556, 1584, 1588, 1599, 1610, 1632, 1649, 1659, 1743, 1849, 1920, 1963, 1997, 2001, 2004, 2019, 2026, 2139, 2174, 2250, 2350, 2372, 2394, 2401, 2446, 2450, 2456, 2487, 2493, 2503, 2512, 2520, 2541, 2544, 2550, 2558, 2577, 2587, 2598, 2686, 2706, 2712, 2726, 2753, 2768, 2772, 2779, 2843, 2853, 2862, 2874, 2908, 2945, 2952, 2969, 3009, 3016, 3019, 3024, 3027, 3031, 3041, 3045, 3053, 3065, 3077, 3095, 3099, 3103, 3107, 3114, 3122, 3127, 3145, 3155, 3171, 3178, 3186, 3193, 3207, 3220, 3239, 3277, 3285, 3328, 3366, 3372, 3376, 3393, 3399, 3433, 3444, 3463, 3469, 3474, 3489, 3502, 3533, 3536, 3541, 3550, 3559, 3583, 3594, 3605, 3616, 3624, 3640, 3647, 3654, 3659, 3679, 3718, 3790, 3794, 3803, 3817, 3827, 3844, 3860, 3868, 3880, 3887, 3911, 3955, 3970, 4027, 4063, 4082, 4088, 4098, 4109, 4115, 4138, 4142, 4167, 4181, 4186, 4212, 4217, 4224, 4227, 4233, 4235, 4240, 4258, 4294, 4310, 4318, 4327, 4335, 4344, 4356, 4396, 4406, 4455, 4482, 4498, 4508, 4520, 4557, 4567, 4584, 4608, 4612, 4616, 4629, 4638, 4679, 4691, 4694, 4711, 4735, 4790, 4801, 4817, 4822, 4830, 4843, 4855, 4866, 4874, 4900, 4905, 4931, 4949, 4979, 5009, 5014, 5016, 5031, 5057, 5064, 5093, 5099, 5126, 5155, 5159, 5182, 5187, 5193, 5214, 5279, 5291, 5295, 5304, 5315, 5334, 5376, 5391, 5395, 5398, 5407, 5418, 5423, 5450, 5467, 5485, 5492, 5496, 5509, 5522, 5538, 5542, 5601, 5643, 5646, 5655, 5665, 5669, 5683, 5689, 5702, 5710, 5720, 5739, 5803, 5815, 5842, 5879, 5905, 5922, 5937, 6019, 6029, 6034, 6054, 6117, 6138, 6142, 6170, 6200, 6209, 6214, 6238, 6245, 6248, 6262, 6278, 6282, 6311, 6332, 6335, 6341], 'on': [47, 59, 124, 200, 212, 277, 1927, 2611, 2894, 3126, 3488, 3612, 4014, 4161, 4204, 4580, 4661, 4731, 5109, 5381, 5584], 'protein.': [50, 203, 2403, 3294, 5498, 5704], 'Despite': [51, 204], 'opposite': [53, 206], 'effects': [54, 207, 2893, 4013, 5203], 'activity,': [61, 214], 'both': [62, 215, 384, 459, 902, 1616, 2758, 3692, 3723, 5433, 5473], 'nucleotides': [63, 216, 2002, 2432, 3385, 3830], 'induce': [64, 217, 498, 1173, 1587], 'formation': [65, 218, 500, 511, 682, 932, 1205, 1589, 2719, 2844, 2854, 2898, 2920, 2925, 2930, 3700, 3842, 3990, 4067, 5355, 5387, 5424, 5468, 5670, 5690, 5740, 6061, 6233], 'oligomers.': [68, 221, 3427], 'By': [69, 222, 570, 2860], 'using': [70, 223, 1790, 2073, 2381, 2621, 2663, 3030, 4359, 4583, 5163, 5251, 5789, 6204], 'a': [71, 89, 224, 242, 309, 314, 393, 403, 439, 483, 558, 581, 617, 630, 636, 684, 885, 935, 1103, 1198, 1242, 1307, 1317, 1331, 1388, 1397, 1405, 1645, 1670, 1928, 1967, 1981, 2030, 2091, 2315, 2382, 2410, 2416, 2435, 2509, 2568, 2612, 2664, 2856, 2868, 2886, 2902, 2988, 3190, 3197, 3257, 3268, 3288, 3314, 3336, 3495, 3525, 3573, 3664, 3672, 4002, 4113, 4156, 4274, 4363, 4367, 4402, 4419, 4450, 4503, 4714, 4783, 4908, 5036, 5196, 5350, 5363, 5504, 5536, 5597, 5650, 5697, 5790, 5932, 5970, 6187, 6229, 6241, 6258, 6290], 'new': [72, 225, 1261, 1309, 4364, 5598], 'technique': [73, 226], 'termed': [74, 227, 447, 5654], 'Gas-phase': [75, 228, 1278], 'Electrophoretic-Mobility': [76, 229], 'Macromolecule': [77, 230], 'Analysis': [78, 231, 1918, 4095, 4307], '(GEMMA),': [79, 232], 'we': [80, 233, 1519, 1549, 1575, 2166, 2178, 2838, 2986, 3142, 3213, 3218, 5042, 5055, 5076, 5370, 5714, 5727, 5754, 6014, 6287], 'have': [81, 88, 234, 241, 2767, 4017, 5204, 5371, 5519, 5551, 5813, 6015, 6223], 'found': [82, 235, 1576, 2839, 3143], 'that': [83, 134, 236, 287, 382, 406, 488, 577, 639, 929, 986, 1081, 1095, 1168, 1200, 1244, 1250, 1577, 1580, 2840, 2916, 2975, 3144, 3217, 3265, 3304, 3462, 3576, 3689, 4056, 4081, 4108, 4497, 4523, 4704, 5181, 5289, 5301, 5347, 5414, 5430, 5446, 5488, 5694, 5756, 5809, 5849, 5921, 6053, 6111, 6226, 6294], 'ATP/dATP-induced': [85, 238], 'oligomers': [87, 240, 991, 1058, 1208, 1253, 3434], 'defined': [90, 243], 'size': [91, 244, 1395, 1542, 2559, 2599, 2863, 2875, 3258, 3271, 3315, 3322, 3337, 3344, 3445, 3491, 3534, 3807, 4187, 4277, 4380, 4601, 4644, 4654, 5818], '(hexamers)': [92, 245], 'can': [94, 113, 247, 266, 1059, 1444, 1481, 1596, 1629, 4290, 5112, 5695, 6114, 6252, 6288], 'interact': [95, 248, 1597, 1630, 4636, 6115], 'with': [96, 249, 610, 801, 1070, 1387, 1448, 1527, 1572, 1598, 1631, 1684, 1962, 2186, 2216, 2231, 2242, 2314, 2626, 2787, 2885, 3206, 3381, 3443, 3865, 4001, 4246, 4273, 4317, 4355, 4366, 4628, 4637, 4870, 5020, 5030, 5255, 5303, 5333, 5526, 5701, 5915, 6033, 6050, 6116], 'dimer': [99, 252, 394, 510, 605, 681, 2919, 3597, 3805, 4675, 4709, 6060], 'form': [101, 141, 254, 294, 1647, 1657, 5338, 5696, 5897, 5931, 6216, 6298], 'enzymatically': [103, 256, 503, 1604], 'active': [104, 118, 257, 271, 424, 504, 1605, 5019], 'protein': [105, 136, 150, 258, 289, 303, 391, 429, 437, 481, 989, 1107, 1155, 1237, 1313, 1319, 1385, 1489, 1499, 1534, 1666, 1681, 1737, 1924, 1959, 2013, 2075, 2084, 2311, 2374, 2396, 2405, 2675, 2717, 2737, 2780, 2904, 2909, 3047, 3058, 3101, 3222, 3251, 3279, 3395, 3661, 3680, 3882, 4117, 4140, 4229, 4260, 4341, 4361, 4408, 4412, 4457, 4510, 4514, 4559, 4589, 4610, 4618, 4640, 4668, 4696, 5297, 5306, 5336, 5494, 5817, 5934, 6263, 6293], '(α6β2).': [107, 260], 'newly': [109, 262, 5880], 'discovered': [110, 263, 5881], 'α6β2': [111, 264, 1636, 1639, 4323, 4651, 4720, 5341, 5353, 5882, 6210], 'either': [114, 267, 1642, 5788], 'be': [115, 268, 536, 580, 1119, 1446, 1482, 1643, 2516, 2879, 3111, 3150, 3578, 4192, 4265, 4291, 4392, 4529, 4861, 5114, 5401, 5478, 5555, 5785, 5807, 6148, 6175, 6273], 'in': [116, 269, 359, 426, 588, 635, 937, 978, 992, 1110, 1212, 1227, 1240, 1315, 1396, 1609, 1644, 1648, 1654, 1658, 1669, 2003, 2087, 2180, 2240, 2371, 2415, 2492, 2597, 2669, 2711, 2725, 2771, 2944, 3015, 3052, 3060, 3081, 3201, 3224, 3227, 3238, 3253, 3282, 3332, 3398, 3498, 3549, 3567, 3608, 3709, 3798, 3816, 3826, 3843, 3886, 3939, 3954, 3999, 4141, 4180, 4211, 4343, 4399, 4425, 4458, 4519, 4600, 4829, 4854, 4904, 5013, 5073, 5092, 5158, 5192, 5290, 5307, 5314, 5547, 5722, 5819, 5833, 5913, 5936, 6047, 6141, 6190, 6195, 6220, 6261, 6269, 6281], 'or': [119, 127, 272, 280, 496, 1001, 1249, 1614, 1653, 2728, 2757, 2850, 3072, 3139, 3707, 3722, 4059, 4131, 4611, 4665, 5471, 5661, 5735, 5797, 5888], 'inhibited': [121, 274], 'state': [122, 275], 'depending': [123, 276, 3611, 4660], 'whether': [125, 278, 1056, 1234, 4326, 4662, 5878, 5889, 6286], 'bound.': [130, 283], 'Our': [131, 284, 5705], 'results': [132, 285, 2789, 3025, 3641, 4357, 5051, 5482, 5524, 5903, 6044, 6052], 'suggest': [133, 286], 'this': [135, 288, 549, 572, 792, 1165, 1413, 1547, 2537, 2865, 3283, 3570, 3940, 3962, 3978, 4554, 4646, 4685, 5026, 5074, 5464, 5898, 5977, 6012, 6168, 6191, 6254, 6303], 'major': [140, 293, 6215], 'at': [145, 298, 543, 1102, 1417, 1689, 1992, 2132, 2347, 2361, 2390, 2445, 2536, 2557, 3151, 3524, 3631, 3977, 4385, 4777, 4794, 4833, 5035, 5082, 5096, 5141, 5174, 5828, 6167, 6176, 6327], 'physiological': [146, 299], 'levels': [147, 300, 712, 718], 'R1-R2': [149, 302, 513, 1083, 4532, 4563, 4581, 5382, 5500], 'nucleotides.': [152, 305, 1956, 2451], 'key': [310], 'synthesize': [313], 'balanced': [315, 582], 'supply': [316, 583], 'four': [319, 586, 724, 3416], 'dNTPs': [320, 587, 714, 827], 'used': [321, 542, 1285, 1296, 1483, 2239, 2288, 2389, 2444, 2483, 2575, 3200, 3281, 3998, 4793, 4809, 5682], 'synthesis': [327], '(1Nordlund': [328, 772, 5859], 'P.': [329, 331, 773, 775, 1123, 1363, 1461, 1715, 1717, 1878, 1880, 3734, 3915, 4031, 4983, 5218, 5562, 5860, 5862, 5944, 5981], 'Reichard': [330, 774, 5861, 5943], 'Annu.': [332, 776, 5863], 'Rev.': [333, 777, 5864], 'Biochem.': [334, 778, 5865, 6157], '2006;': [335, 779, 1131, 5570, 5866], '75:': [336, 780, 5867], '681-706Crossref': [337, 781, 5868], 'PubMed': [338, 523, 674, 753, 782, 819, 874, 956, 969, 1015, 1028, 1048, 1139, 1191, 1351, 1374, 1472, 1512, 1731, 1774, 1815, 1840, 1894, 1911, 2158, 2276, 2297, 2802, 2815, 2835, 3752, 3771, 3784, 3933, 4049, 4442, 4548, 4759, 4772, 4886, 4961, 5001, 5236, 5578, 5619, 5632, 5869, 5951, 6005, 6074, 6087, 6107, 6132, 6161], 'Scopus': [339, 524, 675, 754, 783, 820, 957, 970, 1016, 1029, 1140, 1192, 1352, 1375, 1473, 1513, 1775, 1841, 1912, 2159, 2277, 2298, 2803, 2816, 3515, 3753, 3772, 3785, 3934, 4050, 4443, 4549, 4760, 4773, 4887, 4962, 5002, 5237, 5579, 5620, 5633, 5870, 5952, 6006, 6075, 6088, 6133, 6162], '(795)': [340, 784, 5871], 'Google': [341, 526, 677, 756, 785, 822, 875, 959, 972, 1018, 1031, 1049, 1142, 1194, 1354, 1377, 1475, 1515, 1732, 1777, 1816, 1843, 1895, 1914, 2161, 2279, 2300, 2805, 2818, 2836, 3517, 3755, 3774, 3787, 3936, 4052, 4445, 4551, 4762, 4775, 4889, 4964, 5004, 5239, 5581, 5622, 5635, 5872, 5954, 5967, 6008, 6077, 6090, 6108, 6135, 6164], 'Scholar).': [342, 527, 678, 757, 786, 823, 876, 973, 1050, 1143, 1195, 1378, 1476, 1516, 1733, 1778, 1844, 1915, 2162, 2280, 3518, 3788, 3937, 4053, 4552, 4890, 4965, 5240, 5582, 5636, 5873, 6009, 6136], 'reduces': [347, 553], 'ribonucleoside': [348], 'diphosphates': [349], 'corresponding': [352, 4228, 4259, 4374], 'deoxyribonucleoside': [353], 'diphosphates,': [354], 'further': [357, 6308], 'metabolized': [358], 'cell': [361, 1112, 6143], 'become': [363, 1619], 'dCTP,': [364], 'dTTP,': [365, 2321, 5294], 'dATP,': [366, 4184, 4215], 'dGTP.': [368], 'This': [369, 4411, 4513, 5637], 'consists': [371], 'two': [373, 443, 627, 1522, 3038, 3311], 'different': [374, 1856, 1955, 2591, 3204, 4926], 'proteins': [375, 1783, 1853, 2226, 2554, 2593, 3493, 3506, 3628, 5517, 5546], 'required': [385], 'enzymatic': [387, 5723], 'activity.': [388, 2982, 5049, 5360], '(2': [395, 2681, 4477, 4913, 4970], '×': [396, 2682, 3324, 3346, 4478], '45': [397, 3325], 'kDa),': [398, 3326, 3809, 4480], 'each': [400, 1382, 1440, 1525, 4360, 5916], 'polypeptide': [401, 650], 'contains': [402, 438, 5850], 'tyrosyl': [404, 420], 'radical': [405, 421], 'generated': [408, 1380, 3539], 'stabilized': [410], 'iron': [413], 'center.': [414], 'Electrons': [415], 'shuttled': [417], 'between': [418, 722, 1855, 2077, 3601, 3639, 4026, 4073, 4285, 4719, 5213, 5352, 6231], 'where': [430, 602, 1113], 'actual': [432], 'catalysis': [433], 'occurs.': [434], 'substrate-binding': [440], 'effector-binding': [445], 'sites': [446, 904, 1618, 2760, 3694, 3725, 4029, 4746, 4896, 5216, 5435, 5475, 6172], 'specificity': [449, 470, 493, 529, 595, 618, 688, 805, 887, 1585, 2754, 3673, 3719, 3869, 3912, 4003, 4785, 4980, 5197, 5419, 5644, 6055], 'sites,': [452, 461], 'respectively.': [453, 3092], 'bind': [457, 466, 490, 1060, 1248, 1581, 4334, 4799, 5416, 5431, 5462, 5495], 'whereas': [462, 3327, 3604, 5313, 5428], 'dGTP': [463, 566, 3075, 3706, 3892, 3907], 'dTTP': [465, 561, 2236, 2841, 2917, 4347, 4912, 4969, 5022, 5162, 5260, 5320], 'only': [468, 489, 803, 1582, 3572, 4209, 4566, 4672, 5021, 5415, 5447, 5520], 'site.': [471, 1305, 5132], 'In': [472, 557, 1408, 1546, 1570, 2163, 2189, 2785, 3390, 3653, 3961, 6180], 'absence': [474, 2727, 2953, 3240, 3655, 3818, 4182, 5160], 'nucleotide': [476, 1170, 1553, 1578, 3067, 3157, 3180, 5058], 'effectors,': [477, 3658, 5393], '90-kDa': [484], 'monomer.': [485], 'Allosteric': [486, 2963], 'effectors': [487, 613, 999, 1171, 1554, 1579, 2248, 2733, 2747, 2769, 3068, 3243, 3688, 4872, 5429, 6057], '(dTTP': [495], 'dGTP)': [497, 4008], 'stimulating': [508], 'interaction': [514, 4533, 4564, 4582, 5501, 6279], '(2Ingemarson': [515, 1183, 6124], 'R.': [516, 741, 1184, 1705, 1767, 1833, 1868, 1904, 3736, 3738, 3917, 3919, 4033, 4035, 4537, 4539, 4985, 4987, 5220, 5222, 6125], 'Thelander': [517, 742, 811, 1126, 1185, 1706, 1720, 1768, 1834, 1869, 1883, 1905, 2150, 2263, 3739, 3763, 3920, 4036, 4429, 4542, 4988, 5223, 5565, 6126], 'L.': [518, 743, 812, 1034, 1127, 1186, 1721, 1769, 1801, 1835, 1884, 1906, 2151, 2264, 2821, 3740, 3764, 3921, 4037, 4430, 4543, 4989, 5224, 5566, 5957, 6093, 6127], 'Biochemistry.': [519, 815, 952, 965, 1011, 1024, 1187, 1770, 1836, 1907, 2154, 2293, 2798, 2811, 3767, 3780, 4544, 4755, 4768, 4882, 4957, 5615, 5628, 6070, 6083, 6128], '1996;': [520, 1188, 1348, 6129], '35:': [521, 1189, 6130], '8603-8609Crossref': [522, 1190, 6131], '(41)': [525, 1193, 6134], 'determines': [531, 1539], 'substrate': [533, 645, 4875, 5166, 5258], 'reduced.': [537], 'When': [538, 616, 824, 4806], '(or': [540, 719, 3386, 4103], 'low': [544, 878, 2538, 3903, 3979, 4221, 4778], 'concentration)': [545], 'bound': [547, 622, 3467, 3690, 4677], 'site,': [550, 4065, 5452, 5645, 5648, 5667], 'CDP': [554, 892, 5164], 'UDP.': [556], 'similar': [559, 1861, 2170, 2228, 2892, 3602, 4173, 4451], 'manner,': [560], 'GDP': [563, 4903, 5256], 'reduction': [564, 2209, 4901], 'ADP': [568], 'reduction.': [569, 895], 'having': [571], 'regulation,': [573], 'ensures': [576], 'there': [578, 4560, 5121, 5321, 5348, 5441, 6227], 'will': [579, 6173, 6272, 6305], 'all': [585, 1169, 3306, 5489, 6046], 'cell.': [590], 'mechanism': [592, 914], 'behind': [593, 915], 'function': [597, 692, 939], 'known': [599, 2871, 3496, 5445, 5456], 'from': [600, 1164, 2000, 2524, 2586, 2679, 3419, 3453, 3642, 3729, 4166, 4298, 4474, 4490, 5390, 5802, 5852, 5904], 'experiments': [601, 985, 1099, 2191, 3374, 3650, 3711, 4079, 5244, 5588, 5823, 6199], 'has': [606, 926, 975, 1231, 4449, 6144, 6240], 'been': [607, 927, 976, 1232, 4018, 4526, 5205, 5372, 5552, 6145], 'crystallized': [608], 'together': [609, 5700], 'various': [611, 1552, 1952, 2429, 2731, 3847, 4328], 'substrates.': [615], 'effector': [620, 3675, 3874, 4005, 4015, 5024, 5199, 5444], 'one': [624, 1384, 4673, 4707], 'polypeptides,': [629], 'conformational': [631], 'change': [632, 6260], 'induced': [634, 1683, 2842, 2852, 3697, 5422, 5437, 5738, 5759], 'connecting': [637], 'loop': [638], 'influences': [640], 'correct': [644], 'second': [648, 4199, 4483, 4504, 4715], '(3Eriksson': [651], 'M.': [652, 658, 814, 1038, 1707, 1805, 1870, 2153, 2825, 3766, 5989, 6097], 'Uhlin': [653, 6351], 'U.': [654], 'Ramaswamy': [655], 'S.': [656, 810, 853, 1036, 1803, 2149, 2823, 3762, 5983, 6095], 'Ekberg': [657], 'Regnström': [659], 'K.': [660], 'Sjöberg': [661, 5992], 'B.M.': [662], 'Eklund': [663], 'H.': [664], 'Structure.': [665], '1997;': [666], '5:': [667], '1077-1092Abstract': [668], 'Full': [669, 671, 748, 750, 871, 1045, 1134, 1136, 1728, 1812, 1891, 2271, 2273, 2832, 3747, 3749, 3928, 3930, 4044, 4046, 4437, 4439, 4996, 4998, 5231, 5233, 5573, 5575, 5964, 6000, 6002, 6104], 'Text': [670, 672, 749, 751, 872, 1046, 1135, 1137, 1729, 1813, 1892, 2272, 2274, 2833, 3748, 3750, 3929, 3931, 4045, 4047, 4438, 4440, 4997, 4999, 5232, 5234, 5574, 5576, 5965, 6001, 6003, 6105], 'PDF': [673, 752, 873, 1047, 1138, 1730, 1814, 1893, 2275, 2834, 3751, 3932, 4048, 4441, 5000, 5235, 5577, 5966, 6004, 6106], '(228)': [676], 'Therefore,': [679, 1229, 3093, 5369, 6208], 'prerequisite': [685], 'regulation': [690, 919, 3105, 5603, 6314], 'properly.': [693], 'regulates': [697], 'overall': [699, 759], 'enzyme,': [703], 'important': [706], 'controlling': [708], 'optimal': [710], 'cellular': [711, 826, 5539], 'too': [716, 2009, 4220], 'high': [717, 2749, 3382, 4795, 5677, 5791], 'imbalance': [721], 'dNTPs)': [725], 'lead': [726], 'increased': [729, 796, 3992, 4689, 5191], 'mutation': [730], 'rate': [731, 2514, 3529, 3547, 3562, 3618, 3792], '(4Chabes': [732], 'A.': [733, 1125, 1719, 1763, 1829, 1882, 1900, 2260, 4428, 4541, 5564, 5985], 'Georgieva': [734], 'B.': [735, 861], 'Domkin': [736, 6326], 'V.': [737], 'Zhao': [738], 'X.': [739], 'Rothstein': [740], 'Cell.': [744, 6156], '2003;': [745, 966, 1025, 2294, 2812, 3781, 4769, 4883, 4958, 5629, 6084], '112:': [746], '391-401Abstract': [747], '(343)': [755], 'controlled': [762], 'induces': [794, 2918, 2923], '(hyperactivity)': [799], 'compared': [800, 3205], 'when': [802, 1066, 3029, 3113, 3859, 3993, 4057, 4358, 4607, 4690, 4792, 5272, 5676, 6203], 'occupied': [808, 1620, 3864, 3871], '(5Eriksson': [809, 3761], 'Åkerman': [813, 1037, 1804, 2152, 2824, 3765, 6096], '1979;': [816, 2155, 3768], '18:': [817, 2156, 3769], '2948-2952Crossref': [818, 3770], '(135)': [821, 3773], 'total': [825, 3156, 3179], 'high,': [829], 'out-competes': [831], 'shut': [843], 'off.': [844, 912], 'effect': [846, 3123, 3485, 4577, 5106, 6189], 'concentration': [850, 1108, 1115, 1968, 2411, 2437, 2448, 2738, 2745, 2905, 2910, 3147, 3158, 3704, 3901, 3980, 4692, 4918, 4967, 5037, 5506, 5792, 6140, 6169, 6192], 'dependent': [851], '(6Eriksson': [852], 'Gudas': [854], 'L.J.': [855], 'Clift': [856], 'S.M.': [857], 'Caras': [858], 'I.W.': [859], 'Ullman': [860], 'Martin': [862], 'Jr.,': [863], 'D.W.': [864], 'J.': [865, 1039, 1128, 1368, 1466, 1722, 1806, 1885, 2265, 2826, 3741, 3922, 4038, 4431, 4990, 5225, 5567, 5945, 5958, 5994, 6098], 'Biol.': [866, 1040, 1129, 1508, 1723, 1807, 1886, 2266, 2827, 3742, 3923, 4039, 4432, 4991, 5226, 5568, 5947, 5959, 5995, 6099], 'Chem.': [867, 1041, 1130, 1347, 1724, 1808, 1887, 2267, 2828, 3743, 3924, 4040, 4433, 4992, 5227, 5569, 5960, 5996, 6100], '1981;': [868], '256:': [869], '10193-10197Abstract': [870], 'At': [877, 896], 'concentrations': [879, 1953, 3135, 3383, 4779, 4797, 5061, 5148, 5540, 5678, 5830], '(∼2': [880], 'μm),': [881], 'it': [882, 899, 925, 1052, 1149, 1230, 3266, 3947, 4448, 4813, 5453, 5458], 'acts': [883, 4781], 'pure': [886, 4784], 'regulator': [889, 4787], 'directs': [891], 'UDP': [894], 'higher': [897, 1105, 1245, 3176, 6242], 'concentrations,': [898], 'binds': [900, 4061, 4815, 5448, 5663], 'then': [906, 1622, 2238, 2547, 4189, 5172], 'turned': [911], 'not': [921, 1054, 2184, 2783, 2979, 3163, 3379, 3974, 3984, 4196, 4391, 4462, 4627, 4688, 4700, 5088, 5455, 5708, 5716, 5729, 5779, 5876], 'well': [922, 1739, 2884, 3442, 4272, 6024], 'understood,': [923], 'but': [924, 1491, 1858, 3569, 3969, 4216, 4447, 4626, 4788, 5969, 6247], 'suggested': [928, 4741], 'oligomer': [931], 'might': [933, 5812], 'play': [934], 'role': [936], '(7Kashlan': [944, 1003, 2790, 4747, 5607, 6062], 'O.B.': [945, 962, 1004, 1021, 2290, 2791, 2808, 3777, 4748, 4765, 4879, 4954, 5608, 5625, 6063, 6080], 'Scott': [946, 1005, 2792, 4749, 5609, 6064], 'C.P.': [947, 1006, 2793, 4750, 5610, 6065], 'Lear': [948, 1007, 2794, 4751, 5611, 6066], 'J.D.': [949, 1008, 2795, 4752, 5612, 6067], 'Cooperman': [950, 963, 1009, 1022, 2291, 2796, 2809, 3778, 4753, 4766, 4880, 4955, 5613, 5626, 6068, 6081], 'B.S.': [951, 964, 1010, 1023, 2292, 2797, 2810, 3779, 4754, 4767, 4881, 4956, 5614, 5627, 6069, 6082], '2002;': [953, 1012, 1509, 2799, 4756, 5616, 6071], '41:': [954, 1013, 2800, 4757, 5617, 6072], '462-474Crossref': [955, 1014, 2801, 4758, 5618, 6073], '(95)': [958, 1017, 2804, 4761, 5621, 6076], 'Scholar,': [960, 1019, 1032, 1355, 1896, 2806, 2819, 3775, 4763, 5623, 5955, 6078, 6091], '8Kashlan': [961, 1020, 2807, 3776, 4764, 5624, 6079], '42:': [967, 1026, 2295, 2813, 3782, 4770, 4884, 4959, 5630, 6085], '1696-1706Crossref': [968, 1027, 2296, 2814, 3783, 4771, 4885, 4960, 5631, 6086], '(80)': [971, 1030, 2299, 2817, 3786, 4774, 4888, 4963, 5634, 6089], 'It': [974, 1196, 2762, 4702, 5178, 5805, 5918], 'observed': [977, 4020, 4499, 4573, 5206, 5271, 5755], 'glycerol': [979, 1075, 1213], 'gradients': [980, 1076, 1214], 'dynamic': [982, 1216, 5585, 5820], 'light': [983, 1217, 1788, 5586, 5821], 'scattering': [984, 1218, 5587, 5822], 'forms': [990, 5490, 6339], 'presence': [994, 1611, 1650, 1660, 2729, 2946, 3017, 3400, 3828, 3845, 3888, 3956, 4143, 4213, 4345, 4906, 5194, 5292, 5316, 5938], '9Thelander': [1033, 2820, 6092], 'Eriksson': [1035, 1802, 2148, 2822, 6094], '1980;': [1042, 1809, 2829, 6101], '255:': [1043, 1810, 2830, 6102], '7426-7432Abstract': [1044, 1811, 2831, 6103], 'However,': [1051, 1431, 1608, 2233, 5675, 5750, 6137], 'was': [1053, 1094, 1150, 1167, 1667, 1682, 1746, 1925, 1960, 1978, 1990, 2130, 2144, 2193, 2214, 2237, 2285, 2352, 2442, 2498, 2532, 2546, 2574, 2584, 2595, 2609, 2661, 2723, 2748, 2763, 2876, 2899, 3048, 3059, 3117, 3166, 3396, 3435, 3461, 3522, 3571, 3662, 3714, 3811, 3863, 3883, 3902, 3948, 3973, 3991, 3997, 4118, 4177, 4188, 4208, 4219, 4237, 4244, 4262, 4372, 4409, 4472, 4489, 4511, 4561, 4591, 4619, 4633, 4676, 4687, 4697, 4739, 4837, 4858, 4876, 4921, 4941, 4972, 5171, 5270, 5276, 5919], 'clear': [1055], 'these': [1057, 1098, 1544, 2190, 3710, 6112], 'subunit.': [1063, 1161], 'A': [1064, 3246, 3456, 3556, 3833, 4172, 4198, 4827, 5263], 'problem': [1065, 3457, 3497, 3575], 'studying': [1067], 'traditional': [1071], 'methods': [1072, 1523], 'such': [1073, 1241, 3614], 'gel': [1078, 1564, 2379, 2721, 3208, 3228, 3648, 4077, 4132, 5770, 6042, 6197], 'filtration': [1079, 2380, 2722, 3209, 3649, 4078, 5771, 6043, 6198], 'complexes': [1084, 1226, 1246, 1314, 1500, 1535, 2021, 2676, 2781, 3223, 3856, 3951, 4330, 4342, 4398, 4492, 5342], 'unstable': [1086], 'fall': [1088], 'apart': [1089], 'during': [1090, 3459, 3540], 'analysis.': [1091, 1975, 5368], 'Another': [1092], 'uncertainty': [1093], 'many': [1096, 4894, 5379], 'were': [1100, 1784, 1859, 2022, 2071, 2206, 2312, 2376, 2407, 2482, 2555, 2634, 2677, 2941, 3235, 3280, 3298, 3598, 3629, 3857, 3944, 3966, 4022, 4331, 4348, 4501, 4572, 4868, 4929, 5052, 5151, 5209, 5248, 5322], 'performed': [1101, 1991, 2072, 2215, 2724, 3630, 5525], '100-fold': [1104], 'than': [1109, 1210, 1428, 3177, 4129, 6244], 'estimated': [1117, 3429, 5553, 6146], '0.05': [1120, 1685, 5531, 5556], 'mg/ml': [1121, 1971, 2414, 2666, 2741, 2913, 5528, 5532], '(10Håkansson': [1122, 5561], 'Hofer': [1124, 5563], '281:': [1132, 5571], '7834-7841Abstract': [1133, 5572], '(223)': [1141, 5580], 'With': [1144, 4553], 'Surface': [1145], 'Plasmon': [1146], 'Resonance': [1147], '(Biacore),': [1148], 'possible': [1151, 5180], 'measure': [1153], 'immobilized': [1159, 1239], 'conclusion': [1163], 'study': [1166, 1312, 5375, 5973, 6018, 6301], 'strongly': [1172, 1495], 'dimers': [1178, 1211, 1595, 2847, 3682, 4476, 5300, 5328, 6113], 'subunit': [1182], 'paradox': [1199], 'dATP/ATP,': [1201], 'rather': [1209, 1427], 'experiments,': [1219], 'strongest': [1222], 'inducer': [1223], 'Biacore.': [1228], 'questioned': [1233], 'way': [1243], 'cannot': [1247, 5806], 'destabilized': [1255], 'chip': [1258], 'surface.': [1259], 'Obviously,': [1260], 'techniques': [1262], 'needed': [1264, 2765, 3369, 5152], 'clarify': [1266, 6011], 'how': [1267, 1551, 4893], 'influence': [1271, 5377], 'quaternary': [1276, 1557], 'structure.': [1277, 6264], 'electrophoretic-mobility': [1279, 1289, 1300], 'macromolecule': [1280, 1290, 1301], 'analysis': [1281, 2985, 3460, 3878, 5068, 5287], '(GEMMA)': [1282], '2The': [1283], 'abbreviations': [1284, 1295], 'are:': [1286, 1297], 'GEMMA,': [1287, 1298, 1566, 3302, 3499, 6038], 'gas-phase': [1288, 1299], 'analysis/analyzer;': [1291, 1302], 'h-site,': [1292, 1303], 'hexamerization': [1293, 1304, 4818, 5656], 'site.2The': [1294], 'relatively': [1308, 1860], 'method': [1310, 1414, 3377, 4128, 5365], 'solution:': [1316], 'diluted': [1318, 2408], 'sample': [1320, 2497], '(usually': [1321], '10': [1322, 2105, 2108, 2322, 2331, 3085], 'ng/μl)': [1323], 'transmitted': [1325], 'into': [1326, 6310], 'gas': [1328], 'phase': [1329, 1938, 1965, 2006], 'charged': [1332], 'reduced': [1333, 2517, 3526, 3545, 3560, 3632, 5056], 'electrospray': [1334, 2460, 3542, 4121], 'process': [1335, 3972], '(11Kaufman': [1336], 'S.L.': [1337, 1361, 1459, 3508], 'Skogen': [1338], 'J.W.': [1339], 'Dorman': [1340], 'F.D.': [1341], 'Zarrin': [1342], 'F.': [1343, 1502, 1713, 1876], 'Lewis': [1344], 'K.C.': [1345], 'Anal.': [1346, 3509], '68:': [1349], '1895-1904Crossref': [1350], '(187)': [1353], '12Bacher': [1356], 'G.': [1357, 1367, 1455, 1465, 1711, 1874], 'Szymanski': [1358, 1456], 'W.W.': [1359, 1457], 'Kaufman': [1360, 1458], 'Zollner': [1362, 1460], 'Blaas': [1364, 1462], 'D.': [1365, 1463], 'Allmaier': [1366, 1464], 'Mass': [1369, 1467, 2604, 4093], 'Spectrom.': [1370, 1468], '2001;': [1371, 1469], '36:': [1372, 1470], '1038-1052Crossref': [1373, 1471], '(202)': [1376, 1474], 'particles,': [1381], 'containing': [1383, 2093, 2384, 2418], 'molecule': [1386], '+1': [1389], 'charge,': [1390], 'separated': [1392], 'according': [1393], 'differential': [1398, 2467], 'mobility': [1399, 2468], 'analyzer': [1400], 'subsequently': [1402], 'quantified': [1403, 1785, 2253], 'particle': [1406, 1426, 1433, 2474, 2569, 2582], 'counter.': [1407], 'contrast': [1409], 'mass': [1411, 1436, 1443, 1479, 1537, 1568, 2032, 2579, 2607, 3431, 3796, 4123, 4135, 4225, 4256, 4296, 4368, 4683, 6039], 'spectrometry,': [1412, 6040], 'run': [1416, 2610], 'atmospheric': [1418], 'pressure': [1419, 2522], 'measures': [1421], 'diameter': [1423, 1434], 'mass.': [1430], 'because': [1432, 2936, 3375, 5713, 5726], 'correlated': [1438], 'other,': [1441, 1526], 'usually': [1445], 'determined': [1447, 2877, 4190], 'error': [1450], '±': [1452, 3050, 3086, 3090, 3261, 3318, 3340, 3437, 4267, 4604, 6150], '5.6%': [1453], '(12Bacher': [1454], 'Electrospray': [1477], 'ionization': [1478, 4122], 'spectrometry': [1480, 1538, 2608, 4124], 'obtain': [1485], 'exact': [1486, 1541], 'masses': [1487, 2017, 2673], 'complexes,': [1490], 'sensitivity': [1493, 2011], 'biased': [1496], 'toward': [1497], 'small': [1498, 3505, 6259], '(13Sobott': [1501], 'Robinson': [1503], 'C.V.': [1504], 'Curr.': [1505], 'Opin.': [1506], 'Struct.': [1507], '12:': [1510], '729-734Crossref': [1511], '(128)': [1514], 'Taken': [1517], 'together,': [1518], 'think': [1520], 'complement': [1524], 'GEMMA': [1528, 2181, 2453, 2970, 2976, 2984, 3020, 3054, 3078, 3115, 3182, 3202, 3225, 3349, 3373, 3643, 3877, 4074, 4083, 4130, 4306, 4351, 4938, 5067, 5243, 5286, 5361, 5481, 5523, 5766, 6035], 'providing': [1529, 6331], 'quantitative': [1530], 'information': [1531], 'about': [1532], 'while': [1536], 'complexes.': [1545, 1637, 4092], 'study,': [1548], 'analyzed': [1550, 1926, 3236, 3299, 3839, 4119], 'affect': [1555, 2980], 'structure': [1558, 4378, 4652, 6123], 'mouse': [1560, 1735], 'filtration,': [1565], 'spectrometry.': [1569], 'agreement': [1571, 2786, 3638, 4072, 6049], 'previous': [1573, 2788, 5834, 6051], 'studies,': [1574], 'dimers.': [1592, 3308], 'dimer,': [1601, 1634, 4337, 6246], 'forming': [1602, 1635, 6120], 'complex.': [1607, 2859, 4230], 'hexamers': [1624, 1628, 2938, 3943, 3965, 5470, 5693, 5743, 6201], 'formed.': [1626, 3945], 'These': [1627], 'could': [1641, 2515, 3577, 4390, 5400, 5715, 5784], 'hyperactive': [1646, 5698], 'inactive': [1656, 5672], 'dATP.': [1662], 'Protein': [1663, 2708, 2896, 3188, 3195], 'Purification—The': [1664], 'expressed': [1668, 1747], 'ClpB-negative': [1671, 6355], 'Escherichia': [1672], 'coli': [1673, 5907, 5924, 6021], 'pLysS': [1674], '(DE3)': [1675], 'strain': [1676], '(see': [1677], '“Acknowledgments”).': [1678], 'mm': [1686, 1941, 1944, 1947, 2095, 2098, 2101, 2106, 2112, 2115, 2119, 2197, 2235, 2320, 2323, 2326, 2332, 2335, 2392, 2399, 2420, 2949, 2993, 4150, 4248, 4835, 4945, 5143, 5176, 6152, 6206], 'isopropyl-1-thio-β-d-galactopyranoside': [1687], 'overnight': [1688], '15': [1690], '°C': [1691, 2134, 2363, 2640], 'purified': [1693, 1749], 'ammonium': [1695, 1751, 2198, 2385, 2421, 2994, 4151, 4241, 4249, 4946, 5252], 'sulfate': [1696, 1752], 'precipitation': [1697, 1753], 'dATP-Sepharose': [1699], 'chromatography': [1700, 1756, 2258], 'previously': [1703, 1759, 1865, 4019, 4525, 5207], '(14Davis': [1704, 1867], 'Mann': [1708, 1871], 'G.J.': [1709, 1761, 1827, 1872, 1898], 'Behravan': [1710, 1873], 'Soucy': [1712, 1875], 'Beaulieu': [1714, 1877], 'Lavallee': [1716, 1879], 'Gräslund': [1718, 1762, 1828, 1881, 1899, 4540], '1994;': [1725, 1888, 4545, 6158], '269:': [1726, 1889], '23171-23176Abstract': [1727, 1890], '(as': [1738], 'mutants': [1741], 'protein)': [1745], 'DEAE': [1755], '(15Mann': [1760, 1826], 'Ochiai': [1764, 1830, 1901], 'E.': [1765, 1831, 1902, 5906, 5923, 5991, 6020], 'Ingemarson': [1766, 1832, 1903, 3737, 3918, 4034, 4536, 4986, 5221], '1991;': [1771, 1837, 1908], '30:': [1772, 1838, 1909], '1939-1947Crossref': [1773, 1839, 1910], '(143)': [1776, 1842, 1913], 'UV': [1787, 1982], 'absorption': [1789], 'extinction': [1791], 'coefficients': [1792], 'E1%1': [1794, 1819], 'cm': [1795, 1820], '(280': [1796], 'nm)': [1797, 1822], '=': [1798, 1823], '12.0': [1799], '(9Thelander': [1800], 'Scholar)': [1817, 3756, 6109], '(280–310': [1821], '13.8,': [1824], 'respectively': [1825, 5560], 'specific': [1846, 3042, 3096, 4452], 'activities': [1847, 3083], 'varied': [1854, 3610], 'preparations': [1857], '(±50%)': [1862], 'those': [1864, 2490], 'reported': [1866, 5920], '15Mann': [1897], 'Gel': [1916, 2701], 'Filtration': [1917, 2702], 'Protein—The': [1922], 'Superdex': [1929], '200': [1930, 2683], '10/300': [1931], 'GL': [1932], 'column': [1933, 1977], '(Amersham': [1934, 2103], 'Biosciences).': [1935], 'mobile': [1937, 1964, 2005], 'contained': [1939, 2455], '150': [1940, 2439], 'KCl,': [1942, 2113, 2333], '6': [1943, 2097], 'MgCl2,': [1945, 2099, 2324], '50': [1946, 2088, 2118, 2328, 3069, 3402, 3410, 3890, 4247], 'Tris-HCl,': [1948, 2120], 'pH': [1949, 2121, 2200, 2387, 2423, 2996, 4153, 4251, 5408], '7.6,': [1950, 2201, 2388, 2424, 2997], 'premixed': [1961], '0.02–0.25': [1970], '(100-μl': [1972], 'sample)': [1973], 'before': [1974, 4873], 'connected': [1979], 'detector': [1983], '(UV': [1984], '2075': [1985], 'Plus;': [1986], 'Jasco),': [1987], 'detection': [1989], '290': [1993], 'nm': [1994, 2563], 'minimize': [1996], 'background': [1998], 'absorbance': [1999], 'without': [2007], 'losing': [2008], 'much': [2010], 'detection.': [2014], 'molecular': [2016, 2031, 2578, 3430, 3795], 'obtained': [2023, 2585, 5053, 5173], 'comparing': [2025, 2861], 'retention': [2027], 'time': [2028, 5487], 'standard': [2033, 2592, 2869, 3032, 4932], 'composed': [2034], 'thyroglobulin': [2036], '(669': [2037], 'kDa;': [2038, 2043, 2048, 2053, 2058, 2064], '17.14': [2039], 'min),': [2040, 2045, 2050, 2055, 2060], 'ferritin': [2041], '(440': [2042], '20.08': [2044], 'IgG': [2046], '(159': [2047], '23.39': [2049], 'transferrin': [2051], '(80': [2052], '26.76': [2054], 'ovalbumin': [2056], '(43': [2057], '29.63': [2059], 'myoglobin': [2062], '(16.9': [2063], '33.87': [2065], 'min).': [2066], 'Reductase': [2068], 'Assays—Enzyme': [2069], 'assays': [2070, 4460, 5247, 5724], '(varied': [2076], '0': [2078], '2': [2080, 2234, 2319, 2665, 3323, 3345, 4281, 4658], 'μg)': [2081, 2086], '(4': [2085], 'μl': [2089, 2628], 'buffer': [2092, 2171, 2316, 2383, 2417, 2774, 2989, 3021, 3055, 3079, 3116, 3199, 4084, 4243, 5254], '3': [2094, 2948, 6149, 6205], 'ATP,': [2096, 5041], '0.5': [2100, 5142], '[5-3H]CDP': [2102], 'Biosciences),': [2104], 'dithiothreitol,': [2107, 2327], 'μm': [2109, 2329, 2357, 3070, 3074, 3138, 3403, 3406, 3411, 3677, 3891, 3895, 3959, 3995, 4007, 4146, 5040, 5084, 5274], 'FeCl3,': [2110, 2330], '100': [2111, 2356, 2398, 3049, 3073, 3137, 3958, 3994, 5039, 5083, 5273], '8': [2114], 'Hepes-KOH,': [2116], '7.6': [2122], '(Tris/KCl': [2123], 'buffer).': [2124], 'reaction': [2126, 4791, 5280], 'mixture': [2127, 3521, 5281], '(50': [2128, 3405, 3676, 3712, 4006], 'μl)': [2129], 'incubated': [2131, 2360], '37': [2133, 2362], '30': [2136], 'min,': [2137], 'amount': [2140, 3172, 4910], '[5-3H]dCDP': [2142], 'formed': [2143, 2252, 2943, 3307, 3681, 3858, 3953, 4179, 4210, 5299], 'measured': [2145, 2678, 3008, 3397, 3490, 3812, 4349, 4922, 5745], '(16Engström': [2146], 'Y.': [2147], '2941-2948Crossref': [2157], '(119)': [2160], 'some': [2164, 3964, 5854, 5857], 'cases,': [2165, 3800], 'wanted': [2167, 2972, 3214], 'use': [2169, 2179], 'conditions': [2172, 2229, 2977, 4928, 4939, 5102, 5753], 'assay': [2176, 2351, 4927, 5101], '(GEMMA': [2182, 3130], 'compatible': [2185, 3380], 'non-volatile': [2187, 2368, 3388], 'salts).': [2188, 3389], 'KCl': [2192], 'excluded': [2194, 4238, 5808], '20': [2196, 2205, 2391, 2419, 2590, 2992, 3001, 4145, 4149, 4944], 'acetate,': [2199, 2386, 2422, 2995, 4152], '0.005%': [2203, 2425, 2999], 'Tween': [2204, 2426, 3000], 'added.': [2207], '[8-14C]GDP': [2211], '(Moravek': [2212], 'Biochemicals)': [2213], '2.5': [2217], 'μg': [2218, 2223, 2303, 2308], '4': [2222], 'under': [2227, 5751], 'CDP.': [2232], 'combination': [2241, 4000], 'variable': [2243, 2338], 'amounts': [2244, 2339, 2430, 5325], '[14C]dGDP': [2251], 'after': [2254, 3669], 'separation': [2255], 'boronate': [2257], '(17Hofer': [2259], 'Ekanem': [2261], 'J.T.': [2262], '1998;': [2268], '273:': [2269], '34098-34104Abstract': [2270], '(62)': [2278], 'An': [2281], 'alternative': [2282], 'preincubation-based': [2283, 4951], 'procedure': [2284, 4952], 'also': [2286, 2764, 2914, 3120, 3838, 3967, 4178, 4814, 5686, 5758, 6174, 6224, 6347], 'sometimes': [2287], '(8Kashlan': [2289, 4878, 4953], 'Scholar):': [2301], '5.5': [2302], '4.48': [2307], 'mixed': [2313], '25': [2325, 2348, 2639], '7': [2334, 4516], 'NaF,': [2336], 'ATP.': [2341, 3960, 5085, 5177, 6207], 'After': [2342, 2507], '5': [2343, 2365, 3262, 3319, 3341], 'min': [2344], 'preincubation': [2346], '°C,': [2349], 'initiated': [2353], 'adding': [2355], '[14C]GDP': [2358], 'min.': [2366], 'GEMMA—The': [2367], 'salts': [2369, 3487], 'present': [2370, 2770], 'solution': [2375, 2668], 'removed': [2377], 'samples': [2406], '0.01–0.1': [2413], '20,': [2427], 'up': [2433], 'maximum': [2436], 'μm.': [2440], 'Magnesium': [2441], 'generally': [2443], 'same': [2447, 3221, 3520, 4585], 'system': [2454], 'following': [2457, 2632], 'components:': [2458], '3480': [2459], 'aerosol': [2461], 'generator,': [2462], '3080': [2463], 'electrostatic': [2464], 'classifier,': [2465], '3085': [2466], 'analyzer,': [2469], '3025A': [2471], 'ultrafine': [2472], 'condensation': [2473], 'counter': [2475], '(TSI': [2476], 'Corp.,': [2477], 'Shoreview,': [2478], 'MN).': [2479], 'Most': [2480], 'parameters': [2481, 2633], 'recommended': [2485], 'manufacturer': [2488], 'except': [2489, 3801], 'indicated': [2491], 'figure': [2494], 'legends.': [2495], 'Every': [2496], 'scanned': [2499, 2556], 'several': [2500], 'times': [2501], 'until': [2502], 'signal': [2504], 'became': [2505], 'stable.': [2506], 'obtaining': [2508], 'stable': [2510, 3600], 'signal,': [2511], 'flow': [2513, 3528, 3546, 3561, 3617, 3633, 3791], 'decreasing': [2519], 'capillary': [2521], 'drop': [2523, 3566], '3.7': [2525], '∼1.5–2': [2527], 'psi.': [2528], 'spray': [2530, 2545], 'cone': [2531, 2644], 'difficult': [2533], 'observe': [2535, 5089, 5730], 'pressure,': [2539], 'stability': [2542], 'monitored': [2548], 'current': [2551], 'reading.': [2552], 'range': [2560, 2600, 5507], '2.55–25.5': [2562], '105': [2565], 's/scan,': [2566], 'density': [2570, 2583], '0.58': [2572], 'g/cm3': [2573], 'calculations.': [2580], 'average': [2588, 3036, 5816], 'valid': [2596], '15–900': [2602], 'kDa.': [2603, 3483], 'Spectrometry—The': [2605], 'nanospray': [2606], 'QTOF': [2613], 'Ultima': [2614], 'API': [2615], 'machine': [2616, 2660], '(Micromass': [2617], 'Ltd.,': [2618], 'Manchester,': [2619], 'UK)': [2620], 'gold-coated': [2622], 'borosilicate': [2623], 'needles': [2624], 'loaded': [2625], '∼5': [2627], 'sample.': [2630], 'used:': [2635], '2-kV': [2636], 'needle': [2637], 'voltage,': [2638, 2645], 'source': [2641], 'temperature,': [2642], '100–200-V': [2643, 2646], 'RF': [2647], 'lens': [2648], '1': [2649, 3894, 4811, 4834], 'settings,': [2650], '5–10-eV': [2651], 'collision': [2652], 'energy,': [2653], '2200-V': [2655], 'microchannel': [2656], 'plate': [2657], 'voltage.': [2658], 'calibrated': [2662], 'CsI': [2667], '50%': [2670], 'isopropanol.': [2671], 'smoothed': [2680], 'channels': [2684], 'Savitzky-Golay': [2687], 'smoothing': [2688], 'method)': [2689], 'centroided': [2691], '(100': [2692], 'channels,': [2693], '80%)': [2694], 'data': [2695, 4075, 5706], 'Masslynx': [2697], 'software': [2698], '(Waters': [2699], 'Corp.).': [2700], 'Experiments': [2703, 3183, 3350], 'Show': [2704, 3184, 3351], 'That': [2705, 3185, 3352, 4097, 4309], 'Forms': [2709], 'Hexamers': [2710, 4312], 'Presence': [2713], 'ATP/dATP—Analysis': [2715], '0.2–0.25': [2740], '(Fig.': [2742, 2926, 2956, 3244, 3530, 3644, 3651, 3666, 3683, 3701, 3821, 3831, 3897, 4009, 4253, 4352, 4493, 4574, 4593, 4621, 4641, 4923, 5069, 5103, 5145, 5167, 5282, 5311, 5343], '1A).': [2743], 'enough': [2750, 3715, 3904, 4796, 5460], 'saturate': [2752, 3717, 5154], '(dTTP)': [2756], '(dATP/ATP).': [2761], 'running': [2773], 'avoid': [2776], 'dissociation': [2777], '(data': [2782, 3162, 3983, 4195, 4461, 4699, 5778], 'shown).': [2784, 3164, 3985, 4197, 4463, 4701], 'Scholar),': [2837, 4446, 5005, 5968, 6165], 'large': [2857, 5933], 'globular': [2872], 'proteins,': [2873], '∼544': [2880], 'kDa,': [2881, 3263, 3439, 4269, 4279], 'fits': [2883, 3441, 4271], 'hexamer.': [2887, 4681], 'had': [2891, 3473, 4524, 5043, 5077, 6186], 'oligomerization.': [2895], 'efficient': [2900, 3976], 'throughout': [2901, 5503], 'wide': [2903, 5505], 'range.': [2906], 'Decreasing': [2907], '0.0125': [2912], 'demonstrated': [2915], 'ATP/dATP': [2922, 3353], 'hexamer': [2924, 3699, 3989, 4066, 4275, 4598, 6232, 6239, 6283], '1B).': [2927], 'seemed': [2931, 3109], 'independent': [2932, 5748], 'magnesium': [2934, 2955, 3407, 4236, 5060, 5801], 'ions': [2935], '(0.05': [2939], 'mg/ml)': [2940, 5512, 5516], 'efficiently': [2942], '1B,': [2957], 'bottom': [2958], 'graph).': [2959], 'Enzyme': [2960, 4726], 'Activity': [2961, 4727], 'Regulation': [2964], 'Are': [2965, 4105, 4313], 'Not': [2966], 'Altered': [2967], 'Buffer—We': [2971], 'confirm': [2974, 3216, 4107], 'do': [2978, 5707, 5875], 'For': [2983], 'developed': [2987], 'prevent': [3003], 'nonspecific': [3004, 4299, 5810], 'aggregation.': [3006], 'We': [3007, 3119, 3837, 4054, 5086, 5345, 5874, 6222, 6318, 6346], '(CDP': [3013], 'reduction)': [3014], 'normalized': [3023], 'Tris/KCl-containing': [3033], 'buffer.': [3034, 5804], 'measurements': [3039, 3622, 3760, 3797], '4%': [3051], '(the': [3056, 4850], 'excess).': [3061], 'addition': [3063, 3670, 3686], 'inhibitory': [3066], 'resulted': [3080, 3548], '2%': [3087], '12': [3089], '2%,': [3091], 'neither': [3094], 'nor': [3102], 'altered': [3112, 5769], 'used.': [3118, 3619, 4410, 4512], 'studied': [3121, 4592], 'Mg2+': [3125, 3134, 3146, 3174], 'limited': [3132, 5786], 'below),': [3140], 'needs': [3148], 'least': [3152, 6177], 'equal': [3153, 5324], 'maximal': [3160], 'There': [3165, 3635], 'no': [3167, 4562, 4936, 5123, 5443], 'advantage': [3168], 'increasing': [3170, 4917], 'concentration.': [3181, 5033], 'Is': [3189, 3196, 3363], 'Monomer': [3191], 'Dimer—The': [3198], 'buffer,': [3210, 4935], 'first': [3212, 3310, 4465, 5486], 'get': [3219], 'filtration.': [3229], 'subunits': [3234], 'separately': [3237, 3300], '2,': [3245], 'B).': [3248], 'shown': [3252, 3331, 4527, 5521, 6225], 'Fig.': [3254, 3333, 3391, 4170, 4400], '2A': [3255], 'gave': [3256, 3313, 3335, 4155], '91': [3260, 3317, 3482, 4386], 'suggesting': [3264], 'monomer': [3269, 3552, 3595, 3665], '(theoretical': [3270, 3321, 3343, 3806, 4276, 4379, 4653], '90': [3272], 'kDa).': [3273, 3348, 4382], 'Three': [3274, 4925], 'variants': [3275, 3297, 3312, 4590], 'study:': [3284], 'wild-type': [3286, 4456, 6336], 'protein,': [3287, 3290, 4631, 6119], 'C-terminal-truncated': [3289], 'N-terminal-truncated': [3293, 3329, 4666], 'three': [3296, 4744, 5100, 5640, 5747], 'showing': [3303], 'they': [3305], 'kDa': [3320, 3342, 3479, 3815, 3825, 4194, 4371, 4389, 4606, 4656], 'variant': [3330, 4404, 4506, 4555, 4614], '2B': [3334], '81': [3339, 4470], '38': [3347, 4479], 'Always': [3354], 'Induces': [3355], 'Hexamer': [3357], 'Formation,': [3358], 'Regardless': [3359], 'Which': [3361], 'Effector': [3362], 'Bound': [3364], 'Specificity': [3367], 'Site—We': [3368], 'optimize': [3371], 'other': [3387, 4304, 5890, 6026], '3A,': [3392], 'Mg-dATP': [3404, 3454, 3464, 4147], 'acetate': [3408, 4242, 5253], 'dATP).': [3412], 'graph': [3414], 'shows': [3415], 'peaks': [3417, 4159, 4176, 4202, 4384, 4571, 5772], 'resulting': [3418], 'salt,': [3420], 'monomers,': [3422], 'dimers,': [3424, 5427], '510': [3436], '29': [3438], 'hexamers.': [3448, 5439, 6299], 'salt': [3450, 3820, 5411], 'peak': [3451, 3589, 4365, 4484, 5774, 5776], 'comes': [3452, 5389], 'clusters.': [3455], 'encountered': [3458], 'clusters': [3465], 'non-specifically': [3466], 'monomer,': [3471], 'appearance': [3475], 'being': [3477, 3553], '101': [3478], 'instead': [3480], 'especially': [3500], 'measurement': [3503, 4089], '(18Kaufman': [3507], 'Chim.': [3510], 'Acta.': [3511], '2000;': [3512, 3744, 3925, 4041, 4434, 4993, 5228], '406:': [3513], '3-10Crossref': [3514], '(45)': [3516], 're-analyzed': [3523], 'liquid': [3527], '3B),': [3531], 'reducing': [3532, 5405], 'primary': [3537], 'droplets': [3538], 'process.': [3543], 'correctly': [3554], 'measured.': [3555], 'drawback': [3557], '∼2-fold': [3565], 'sensitivity,': [3568], 'minor': [3574], 'compensated': [3579], 'doubling': [3582], 'number': [3584], 'scans.': [3586], 'relative': [3588], 'heights': [3590], '(and': [3591], 'areas)': [3592], 'fairly': [3599], 'samples,': [3603], 'absolute': [3606], 'values': [3607, 4289], 'particles/cm3': [3609], 'factors': [3613, 5380], 'All': [3620], 'subsequent': [3621], 'rate.': [3634], 'good': [3637, 4071], '3)': [3645], '1).': [3652], 'mainly': [3663, 4473, 5388], '3C),': [3667], 'Mg-dGTP)': [3678], '3D).': [3684], '(e.g.': [3695, 3875, 5200], 'dATP)': [3696], '3B).': [3702], 'μm)': [3713], '(dGTP)': [3721], '(dATP)': [3726], 'judged': [3728], 'filter': [3730], 'studies': [3732], '(19Reichard': [3733, 3914, 4030, 4982, 5217], 'Eliasson': [3735, 3916, 4032, 4984, 5219], '275:': [3745, 3926, 4042, 4435, 4994, 5229], '33021-33026Abstract': [3746, 3927, 4043, 4995, 5230], '(60)': [3754, 3935, 4051, 5003, 5238], 'Reducing': [3789], 'improved': [3793], 'most': [3799], '180': [3808], '173': [3814, 4487], '3C)': [3822], '193': [3824, 4388], '3,': [3832], 'B,': [3835], 'D–F).': [3836, 4595], 'combinations': [3848], 'effectors.': [3851], 'To': [3852, 4231, 4394, 4495, 4891, 6010], 'investigate': [3853, 4325, 4892], 'another': [3873], 'dGTP),': [3876], 'carried': [3884, 5249], 'out': [3885, 5250, 5800], '3E).': [3898], 'allow': [3906], 'fully': [3909], 'occupy': [3910], 'Also,': [3938], 'case': [3941, 3963, 5075], 'Finally,': [3946, 5241], 'investigated': [3949], 'formed,': [3968], 'oligomerization': [3971], 'so': [3975], 'efficiency': [3987], '3F).': [4010], 'Similar': [4011, 5050, 5202], 'beneficial': [4012], 'affinities': [4016], 'explained': [4023, 4292, 5115, 5210], 'cross-talk': [4025, 5212], 'conclude': [4055, 5346], 'induced.': [4069], 'indicates': [4080], 'appropriate': [4086], 'Spectrometry': [4094], 'Confirms': [4096], 'Oligomers': [4099], 'Induced': [4100], 'ATP)': [4104], 'Hexamers—To': [4106], 'dATP-induced': [4110], 'hexamer,': [4114], '(a': [4125], 'more': [4126, 4863, 5971], 'accurate': [4127], 'filtration).': [4133], 'spectrum': [4136], '7.5,': [4154], 'series': [4157, 4174, 4200], 'centered': [4160, 4203], '5000': [4162], 'm/z': [4163, 4206], 'units': [4164, 4207], '(coming': [4165], 'monomer;': [4169], '4A).': [4171], '90.2': [4193], '12,000': [4205], 'resolution': [4218], 'assign': [4223, 4395], 'increase': [4232], 'resolution,': [4234], 'replaced': [4245, 4942], 'formate,': [4250], '7.5': [4252], '4B).': [4254], 'calculated': [4263], '549.75': [4266], '0.07': [4268], '547.7': [4278], 'including': [4280], 'dATP/polypeptide).': [4282], 'deviation': [4284], 'theoretical': [4286], 'experimental': [4288], 'extra': [4295], 'coming': [4297], 'salts.': [4305], 'Shows': [4308], 'Able': [4314], 'Interact': [4316], 'Protein,': [4320], 'Forming': [4321], 'Complex—To': [4324], 'able': [4332, 5373, 5895, 5929], '5A).': [4353], 'Compared': [4354], 'alone,': [4362], '∼266': [4370], 'observed,': [4373], '270': [4381], 'assigned.': [4393], 'unknown': [4397], '5A,': [4401], 'truncated': [4403, 4505], 'lacks': [4413, 4515], '60': [4414], 'N-terminal': [4415], 'amino': [4416, 4517], 'acids': [4417, 4518], 'encoding': [4418, 6334], 'recognition': [4420], 'ubiquitin-mediated': [4423], 'proteolysis': [4424], 'mitosis': [4426], '(20Chabes': [4427], '17747-17753Abstract': [4436], '(134)': [4444], '(now': [4467], 'shifted': [4468, 4599], 'kDa)': [4471, 4488], '(shifted': [4485], 'αβ2': [4491], '5B).': [4494], 'prove': [4496], 'interactions': [4500, 5399], 'real,': [4502], 'C': [4521], 'terminus': [4522], 'crucial': [4530], '(21Lycksell': [4534], 'P.-O.': [4535], 'Davis': [4538], '33:': [4546], '2838-2842Crossref': [4547], '(44)': [4550], 'β2': [4568], 'α2': [4570], '5C).': [4575], 'set': [4586], '5,': [4594, 4622], '633': [4603], '35': [4605], 'N-terminal-deleted': [4613], 'added': [4620, 4877, 5277], 'D': [4623], 'E)': [4625], 'unable': [4634, 6296], '5F).': [4642], 'corresponded': [4648], '637/623': [4655], '(including': [4657], 'dATP/polypeptide),': [4659], 'wild': [4663], 'type-': [4664], 'used).': [4670], 'Surprisingly,': [4671], 'doubled': [4698], 'appears': [4703], 'prevents': [4710], 'dimer.': [4717], 'Correlation': [4718], 'Complex': [4721], 'Formation': [4722], 'Stimulation': [4724], 'ATP—Partially': [4729], 'based': [4730], 'assays,': [4734, 5592, 6184], 'recently': [4740, 5595], 'contain': [4743], 'Scholar);': [4776], '(∼1': [4804], 'mm).': [4805], 'above': [4810], 'mm,': [4812], '(h-site)': [4820], 'increases': [4825, 5028], 'again.': [4826], 'dip': [4828, 4853, 5091], 'thus': [4838, 5113], 'taken': [4839], 'evidence': [4841], 'existence': [4844, 5127], 'additional': [4847, 5130], 'regulatory': [4848, 5131], 'h-site).': [4851], 'claimed': [4859], 'even': [4862], 'pronounced': [4864], 'if': [4865, 5054, 5457, 5472], 'preincubated': [4869], 'contains,': [4899], 'constant': [4909], 'mm)': [4914, 4971, 5796], '6A).': [4924, 5104, 5146], 'used,': [4930], 'protocol': [4933], '(KCl': [4934, 4940], 'preincubation),': [4937], 'acetate),': [4947], 'published': [4950], 'sufficient': [4973], 'exclude': [4975], 'simplifying': [5006], 'interpretation': [5007], 'results.': [5010], 'As': [5011, 5535], 'seen': [5012], 'figure,': [5015], 'gradually': [5029], 'Already': [5034], 'almost': [5044, 5079], '2-fold': [5045, 5080, 5265], 'stimulation': [5046, 5081, 5134, 5170, 5266, 5357], 'fit': [5063], 'requirements': [5065], '6A,': [5070, 5283], 'inset).': [5071, 5284], 'Also': [5072], 'did': [5087, 5728], 'any': [5090, 5097, 5731], 'binding,': [5119], 'support': [5124, 5709, 5718], 'nearly': [5139, 5264], 'complete': [5140], 'Higher': [5147], '6B).': [5168], 'Maximal': [5169], '∼1': [5175], 'affinity': [5183], 'dTTP).': [5201], 'parallel': [5242], 'effector.': [5262], 'showed': [5288, 5483], 'exclusively': [5298], 'interacted': [5302, 5332], '6C),': [5312], 'approximately': [5323], 'hexamers,': [5330], '6D).': [5344], 'correlation': [5351, 6230], 'quick': [5364], 'allowing': [5366], 'high-throughput': [5367], 'formation.': [5384], 'although': [5394], 'strength': [5396], 'modulated': [5402], 'substrates,': [5404], 'agents,': [5406], 'value,': [5409], 'concentrations.': [5412], 'Effectors': [5413], 'always': [5421, 5436, 5737], 'Because': [5440], 'need': [5476], 'occupied.': [5479, 6179], 'occurred': [5502], '(0.02–0.1': [5511], '(0.01–0.05': [5515], '(we': [5518], '0.1': [5527, 5558], 'protein).': [5534], 'comparison,': [5537], 'logarithmically': [5548], 'growing': [5549], 'cells': [5550], 'mg/ml,': [5559], 'Based': [5583], 'Cooperman′s': [5593], 'laboratory': [5594], 'proposed': [5596, 5711], 'model': [5599, 5638, 5712], 'involves': [5639], 'sites:': [5642], 'third': [5651], 'hypothetical': [5652], '(h-site).': [5658], 'Accordingly,': [5659], 'inducing': [5668, 5688, 6257], 'tetramers.': [5674, 5733], 'h-site': [5684, 5721], 'occupied,': [5687], 'find': [5717], 'dATP/ATP-induced': [5732], 'methods.': [5749], 'certain': [5752, 5829], 'non-specific': [5760], 'aggregation/precipitation': [5761, 5782, 5811], 'leading': [5762], 'clogging': [5764], 'capillaries': [5767], '(reduced': [5773], 'intensities/changed': [5775], 'positions': [5777], 'shown)).': [5780], 'problems': [5783], '(10': [5795], 'leaving': [5799], 'influenced': [5814], 'caused': [5825], 'inhibition': [5827], 'analyses.': [5835], 'belongs': [5840], 'class': [5843, 5891, 5908, 5925, 6030], 'Ia': [5844, 5892, 5909, 5926, 6031], 'family': [5845, 6032], 'reductases': [5848], 'enzymes': [5851, 5893], 'eukaryotes,': [5853], 'bacteria,': [5855], 'viruses': [5858], 'know': [5877], 'unique': [5885], 'mammals': [5887], 'well.': [5901], 'Previous': [5902], 'conflict': [5914], 'other.': [5917], '(22Brown': [5941], 'N.C.': [5942], 'Mol.': [5946, 6155], '1969;': [5948], '46:': [5949], '25-38Crossref': [5950], '(93)': [5953], '23Thelander': [5956], '1973;': [5961], '218:': [5962], '4591-4601Abstract': [5963], 'recent': [5972], 'failed': [5974], 'detect': [5976], '(24Larsson': [5979], 'Birgander': [5980], 'Bug': [5982], 'Kasrayan': [5984], 'Dahlroth': [5986], 'S.-L.': [5987], 'Westman': [5988], 'Gordon': [5990], 'B.-M.': [5993], '2005;': [5997], '280:': [5998], '14997-15003Abstract': [5999], '(10)': [6007], 'issue,': [6013], 'started': [6016], 'representatives': [6027], 'technique.': [6036], 'perfect': [6048], 'stimulate': [6058], '1.7': [6151], '(25Traut': [6153], 'T.W.': [6154], '140:': [6159], '1-22Crossref': [6160], '(1239)': [6163], 'partially': [6178], 'our': [6181, 6196, 6270], 'saturating': [6188], 'range,': [6193], 'dominated': [6202], 'likely': [6213], 'vivo.': [6221], 'activation.': [6236], 'Perhaps': [6237], 'block': [6253], 'next': [6266], 'logical': [6267], 'step': [6268], 'project': [6271], 'try': [6275], 'localize': [6277], 'surfaces': [6280], 'see': [6285], 'make': [6289], 'mutant': [6291, 6304, 6338], 'hopefully': [6306], 'give': [6307], 'insight': [6309], 'reductases.': [6317], 'thank': [6319, 6348], 'Lars': [6320], 'Thelander,': [6321, 6323], 'Margareta': [6322], 'Vladimir': [6325], 'Umeå': [6328], 'University': [6329], 'plasmids': [6333], 'Bernt': [6349], 'Eric': [6350], '(Umeå': [6352], 'University)': [6353], 'BL21(DE3)': [6356], 'cells.': [6357]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2027478967', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2025-01-07T11:14:14.728217', 'created_date': '2016-06-24'}