Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2027132581', 'doi': 'https://doi.org/10.1242/dev.02624', 'title': 'Phosphorylation of IP3R1 and the regulation of[Ca2+]i responses at fertilization: a role for the MAP kinase pathway', 'display_name': 'Phosphorylation of IP3R1 and the regulation of[Ca2+]i responses at fertilization: a role for the MAP kinase pathway', 'publication_year': 2006, 'publication_date': '2006-10-12', 'ids': {'openalex': 'https://openalex.org/W2027132581', 'doi': 'https://doi.org/10.1242/dev.02624', 'mag': '2027132581', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17038520', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2909192'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.02624', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/133/21/4355/1155364/4355.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.biologists.com/dev/article-pdf/133/21/4355/1155364/4355.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100616747', 'display_name': 'Bora Lee', 'orcid': 'https://orcid.org/0000-0003-1599-3140'}, 'institutions': [{'id': 'https://openalex.org/I24603500', 'display_name': 'University of Massachusetts Amherst', 'ror': 'https://ror.org/0072zz521', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I24603500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bora Lee', 'raw_affiliation_strings': ['Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.', 'institution_ids': ['https://openalex.org/I24603500']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051684191', 'display_name': 'Elke Vermassen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Elke Vermassen', 'raw_affiliation_strings': ['Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051427349', 'display_name': 'Sook‐Young Yoon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24603500', 'display_name': 'University of Massachusetts Amherst', 'ror': 'https://ror.org/0072zz521', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I24603500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sook-Young Yoon', 'raw_affiliation_strings': ['Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.', 'institution_ids': ['https://openalex.org/I24603500']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061129469', 'display_name': 'Veerle Vanderheyden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Veerle Vanderheyden', 'raw_affiliation_strings': ['Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075280300', 'display_name': 'Junya Ito', 'orcid': 'https://orcid.org/0000-0001-9398-7358'}, 'institutions': [{'id': 'https://openalex.org/I24603500', 'display_name': 'University of Massachusetts Amherst', 'ror': 'https://ror.org/0072zz521', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I24603500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Junya Ito', 'raw_affiliation_strings': ['Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.', 'institution_ids': ['https://openalex.org/I24603500']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019909975', 'display_name': 'Dominique Alfandari', 'orcid': 'https://orcid.org/0000-0002-0557-1246'}, 'institutions': [{'id': 'https://openalex.org/I24603500', 'display_name': 'University of Massachusetts Amherst', 'ror': 'https://ror.org/0072zz521', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I24603500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dominique Alfandari', 'raw_affiliation_strings': ['Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.', 'institution_ids': ['https://openalex.org/I24603500']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106234921', 'display_name': 'Humbert De Smedt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Humbert De Smedt', 'raw_affiliation_strings': ['Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082879421', 'display_name': 'Jan B. Parys', 'orcid': 'https://orcid.org/0000-0002-3591-4967'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jan B. Parys', 'raw_affiliation_strings': ['Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, bus 802, B-3000 Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028303892', 'display_name': 'Rafael A. Fissore', 'orcid': 'https://orcid.org/0000-0001-5655-0915'}, 'institutions': [{'id': 'https://openalex.org/I24603500', 'display_name': 'University of Massachusetts Amherst', 'ror': 'https://ror.org/0072zz521', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I24603500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rafael A. Fissore', 'raw_affiliation_strings': ['Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01002, USA.', 'institution_ids': ['https://openalex.org/I24603500']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 9.243, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 101, 'citation_normalized_percentile': {'value': 0.945713, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '133', 'issue': '21', 'first_page': '4355', 'last_page': '4365'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10364', 'display_name': 'Fertility Preservation in Cancer Patients', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10364', 'display_name': 'Fertility Preservation in Cancer Patients', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10676', 'display_name': 'Molecular Mechanisms of Aging and Longevity', 'score': 0.9754, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10116', 'display_name': 'Male Reproductive Health', 'score': 0.9566, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/insulin-signaling', 'display_name': 'Insulin Signaling', 'score': 0.496079}, {'id': 'https://openalex.org/keywords/oocyte-activation', 'display_name': 'Oocyte activation', 'score': 0.47699788}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.842589}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.8419516}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.74896187}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.66367936}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.6444548}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.6091852}, {'id': 'https://openalex.org/C2777427919', 'wikidata': 'https://www.wikidata.org/wiki/Q407997', 'display_name': 'Inositol', 'level': 3, 'score': 0.5477941}, {'id': 'https://openalex.org/C179265757', 'wikidata': 'https://www.wikidata.org/wiki/Q7095247', 'display_name': 'Oocyte activation', 'level': 4, 'score': 0.47699788}, {'id': 'https://openalex.org/C88972607', 'wikidata': 'https://www.wikidata.org/wiki/Q2666904', 'display_name': 'Human fertilization', 'level': 2, 'score': 0.4573625}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3596022}, {'id': 'https://openalex.org/C2776690073', 'wikidata': 'https://www.wikidata.org/wiki/Q3246226', 'display_name': 'Oocyte', 'level': 3, 'score': 0.26409435}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2070556}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19663253}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.14408183}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005306', 'descriptor_name': 'Fertilization', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D053496', 'descriptor_name': 'Inositol 1,4,5-Trisphosphate Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045163', 'descriptor_name': 'Antibodies, Phospho-Specific', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045163', 'descriptor_name': 'Antibodies, Phospho-Specific', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005306', 'descriptor_name': 'Fertilization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053496', 'descriptor_name': 'Inositol 1,4,5-Trisphosphate Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053496', 'descriptor_name': 'Inositol 1,4,5-Trisphosphate Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015053', 'descriptor_name': 'Zygote', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015053', 'descriptor_name': 'Zygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.02624', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/133/21/4355/1155364/4355.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2909192', 'pdf_url': 'https://europepmc.org/articles/pmc2909192?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17038520', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.02624', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/133/21/4355/1155364/4355.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.6, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 107, 'referenced_works': ['https://openalex.org/W1497597518', 'https://openalex.org/W1501322875', 'https://openalex.org/W1533156549', 'https://openalex.org/W1583134740', 'https://openalex.org/W1599277155', 'https://openalex.org/W1603199903', 'https://openalex.org/W1807534989', 'https://openalex.org/W1870182969', 'https://openalex.org/W1965334910', 'https://openalex.org/W1972979813', 'https://openalex.org/W1973887883', 'https://openalex.org/W1978008016', 'https://openalex.org/W1978846938', 'https://openalex.org/W1980441940', 'https://openalex.org/W1983188620', 'https://openalex.org/W1984128131', 'https://openalex.org/W1984136613', 'https://openalex.org/W1985333504', 'https://openalex.org/W1987859682', 'https://openalex.org/W1990602082', 'https://openalex.org/W1993995783', 'https://openalex.org/W1998539827', 'https://openalex.org/W2004920022', 'https://openalex.org/W2006357947', 'https://openalex.org/W2007278837', 'https://openalex.org/W2009997286', 'https://openalex.org/W2011393766', 'https://openalex.org/W2011786631', 'https://openalex.org/W2014853697', 'https://openalex.org/W2015426350', 'https://openalex.org/W2015470840', 'https://openalex.org/W2018289835', 'https://openalex.org/W2019559983', 'https://openalex.org/W2021739712', 'https://openalex.org/W2022918606', 'https://openalex.org/W2030910709', 'https://openalex.org/W2032034914', 'https://openalex.org/W2032413267', 'https://openalex.org/W2033620401', 'https://openalex.org/W2034948159', 'https://openalex.org/W2035920388', 'https://openalex.org/W2036932956', 'https://openalex.org/W2040742434', 'https://openalex.org/W2042834905', 'https://openalex.org/W2045399399', 'https://openalex.org/W2049508142', 'https://openalex.org/W2052168854', 'https://openalex.org/W2053766825', 'https://openalex.org/W2063535351', 'https://openalex.org/W2064469550', 'https://openalex.org/W2064541275', 'https://openalex.org/W2064553599', 'https://openalex.org/W2066120939', 'https://openalex.org/W2068004255', 'https://openalex.org/W2070077245', 'https://openalex.org/W2070640442', 'https://openalex.org/W2070690670', 'https://openalex.org/W2071477172', 'https://openalex.org/W2072367029', 'https://openalex.org/W2072437360', 'https://openalex.org/W2072881240', 'https://openalex.org/W2075303962', 'https://openalex.org/W2075523999', 'https://openalex.org/W2076440038', 'https://openalex.org/W2078826636', 'https://openalex.org/W2080871655', 'https://openalex.org/W2081324568', 'https://openalex.org/W2086262311', 'https://openalex.org/W2089259198', 'https://openalex.org/W2090239388', 'https://openalex.org/W2092266051', 'https://openalex.org/W2097939257', 'https://openalex.org/W2099936575', 'https://openalex.org/W2099957469', 'https://openalex.org/W2100837269', 'https://openalex.org/W2101158068', 'https://openalex.org/W2109025431', 'https://openalex.org/W2114595574', 'https://openalex.org/W2115358069', 'https://openalex.org/W2116271245', 'https://openalex.org/W2119741159', 'https://openalex.org/W2132204920', 'https://openalex.org/W2135129680', 'https://openalex.org/W2135273128', 'https://openalex.org/W2138231889', 'https://openalex.org/W2138352138', 'https://openalex.org/W2144553803', 'https://openalex.org/W2145091030', 'https://openalex.org/W2147171758', 'https://openalex.org/W2147610461', 'https://openalex.org/W2157012512', 'https://openalex.org/W2160491587', 'https://openalex.org/W2162071834', 'https://openalex.org/W2163191890', 'https://openalex.org/W2164024995', 'https://openalex.org/W2166988131', 'https://openalex.org/W2170171558', 'https://openalex.org/W2171389484', 'https://openalex.org/W2171392147', 'https://openalex.org/W2176288923', 'https://openalex.org/W2183933522', 'https://openalex.org/W2301131921', 'https://openalex.org/W4205744565', 'https://openalex.org/W4252031808', 'https://openalex.org/W4290198908', 'https://openalex.org/W4322388553', 'https://openalex.org/W46922717'], 'related_works': ['https://openalex.org/W96922311', 'https://openalex.org/W4381684367', 'https://openalex.org/W3186045097', 'https://openalex.org/W2803069890', 'https://openalex.org/W2795496485', 'https://openalex.org/W2265404956', 'https://openalex.org/W2143660051', 'https://openalex.org/W2073295784', 'https://openalex.org/W2062576070', 'https://openalex.org/W1982401259'], 'abstract_inverted_index': {'A': [0], 'sperm-induced': [1], 'intracellular': [2], 'Ca2+': [3, 41, 44], 'signal([Ca2+]i)': [4], 'underlies': [5], 'the': [6, 37, 58, 68, 72, 79, 91, 100, 123, 140, 152, 180, 186, 199], 'initiation': [7], 'of': [8, 39, 60, 71, 103, 137, 151, 179, 198, 230], 'embryo': [9], 'development': [10], 'in': [11, 25, 30, 63, 84, 106, 170, 191, 209, 233], 'most': [12, 88], 'species': [13, 86], 'studied': [14], 'to': [15, 35, 133, 205, 211, 237], 'date.': [16], 'The': [17], 'inositol': [18], '1,4,5': [19], 'trisphosphate': [20], 'receptor': [21], 'type': [22], '1': [23], '(IP3R1)': [24], 'mammals,': [26], 'or': [27], 'its': [28, 165], 'homologue': [29], 'other': [31], 'species,': [32], 'is': [33, 46, 117, 131, 183], 'thought': [34], 'mediate': [36], 'majority': [38], 'this': [40, 95, 171], 'release.': [42], 'IP3R1-mediated': [43], 'release': [45, 239], 'regulated': [47], 'during': [48, 90, 119, 202], 'oocyte': [49], 'maturation': [50, 121, 203], 'such': [51], 'that': [52, 115, 148, 164, 177, 195, 235], 'it': [53], 'reaches': [54], 'maximal': [55], 'effectiveness': [56], 'at': [57, 67, 127, 156, 157, 240], 'time': [59], 'fertilization,': [61], 'which,': [62], 'mammalian': [64], 'eggs,': [65, 112, 193], 'occurs': [66], 'metaphase': [69], 'stage': [70], 'second': [73], 'meiosis': [74], '(MII).': [75], 'Consistent': [76], 'with': [77, 82], 'this,': [78], '[Ca2+]ioscillations': [80], 'associated': [81], 'fertilization': [83], 'these': [85], 'occur': [87], 'prominently': [89], 'MII': [92], 'stage.': [93], 'In': [94, 143], 'study,': [96], 'we': [97, 113], 'have': [98], 'examined': [99], 'molecular': [101], 'underpinnings': [102], 'IP3R1': [104, 116, 155, 168, 187, 216, 221, 231], 'function': [105, 232], 'eggs.': [107], 'Using': [108], 'mouse': [109, 192], 'and': [110, 122, 163, 194, 213], 'Xenopus': [111], 'show': [114, 214], 'phosphorylated': [118], 'both': [120], 'first': [124], 'cell': [125, 141], 'cycle': [126], 'a': [128, 135, 227], 'MPM2-detectable': [129], 'epitope(s),which': [130], 'known': [132], 'be': [134], 'target': [136], 'kinases': [138, 225], 'controlling': [139], 'cycle.': [142], 'vitro': [144], 'phosphorylation': [145, 169, 222], 'studies': [146, 174], 'reveal': [147], 'MAPK/ERK2,': [149], 'one': [150, 159], 'M-phase': [153, 224], 'kinases,phosphorylates': [154], 'least': [158], 'highly': [160], 'conserved': [161], 'site,': [162], 'mutation': [166], 'abrogates': [167], 'domain.': [172], 'Our': [173], 'also': [175], 'found': [176], 'activation': [178], 'MAPK/ERK': [181, 200], 'pathway': [182, 201], 'required': [184], 'for': [185], 'MPM2': [188], 'reactivity': [189], 'observed': [190], 'eggs': [196, 234], 'deprived': [197], 'fail': [204], 'mount': [206], 'normal[Ca2+]i': [207], 'oscillations': [208], 'response': [210], 'agonists': [212], 'compromised': [215], 'function.': [217], 'These': [218], 'findings': [219], 'identify': [220], 'by': [223], 'as': [226], 'regulatory': [228], 'mechanism': [229], 'serves': [236], 'optimize[Ca2+]i': [238], 'fertilization.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2027132581', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-17T15:29:51.048267', 'created_date': '2016-06-24'}