Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2026927141', 'doi': 'https://doi.org/10.1097/00002371-200011000-00002', 'title': 'A Humanized Anti–4-1BB Monoclonal Antibody Suppresses Antigen-Induced Humoral Immune Response in Nonhuman Primates', 'display_name': 'A Humanized Anti–4-1BB Monoclonal Antibody Suppresses Antigen-Induced Humoral Immune Response in Nonhuman Primates', 'publication_year': 2000, 'publication_date': '2000-11-01', 'ids': {'openalex': 'https://openalex.org/W2026927141', 'doi': 'https://doi.org/10.1097/00002371-200011000-00002', 'mag': '2026927141', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11186149'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00002371-200011000-00002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S177451610', 'display_name': 'Journal of Immunotherapy', 'issn_l': '1524-9557', 'issn': ['1524-9557', '1537-4513'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004270946', 'display_name': 'Gi Jeong Cheon', 'orcid': 'https://orcid.org/0000-0002-1360-5186'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hyo J. Hong', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100415726', 'display_name': 'Jae Wook Lee', 'orcid': 'https://orcid.org/0000-0002-1496-472X'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jae W. Lee', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086977364', 'display_name': 'Sung Sup Park', 'orcid': 'https://orcid.org/0000-0003-3754-4848'}, 'institutions': [{'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}, {'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sung Sup Park', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018332997', 'display_name': 'Young Jun Kang', 'orcid': 'https://orcid.org/0000-0001-9778-1963'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': True, 'raw_author_name': 'Young Jun Kang', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030481456', 'display_name': 'Suk‐Joon Chang', 'orcid': 'https://orcid.org/0000-0002-0558-0038'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': True, 'raw_author_name': 'Sun Young Chang', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045219010', 'display_name': 'Kwang-Mi Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}, {'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Kwang-Mi Kim', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013022973', 'display_name': 'Jae‐Ouk Kim', 'orcid': 'https://orcid.org/0000-0002-4556-5553'}, 'institutions': [{'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jae-Ouk Kim', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073158266', 'display_name': 'Krishna K. Murthy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Krishna K. Murthy', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103021431', 'display_name': 'Jennifer Shepard Payne', 'orcid': 'https://orcid.org/0000-0003-3314-6500'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer S. Payne', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017338959', 'display_name': 'Seong Jun Yoon', 'orcid': 'https://orcid.org/0000-0001-7614-1182'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sung Kwan Yoon', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100861178', 'display_name': 'Mi-Jeong Park', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mi-Jeong Park', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081625960', 'display_name': 'In Chull Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'In-Chull Kim', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050017807', 'display_name': 'Joong Gon Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Joong Gon Kim', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012450211', 'display_name': 'Chang–Yuil Kang', 'orcid': 'https://orcid.org/0000-0002-1843-6967'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}, {'id': 'https://openalex.org/I1289525096', 'display_name': 'Texas Biomedical Research Institute', 'ror': 'https://ror.org/00wbskb04', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1289525096']}], 'countries': ['KR', 'US'], 'is_corresponding': True, 'raw_author_name': 'Chang-Yuil Kang', 'raw_affiliation_strings': ['Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'Received January 4, 2000', 'accepted July 5, 2000.', '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', '‡Southwest Foundation for Biomedical Research, San Antonio, Texas'], 'affiliations': [{'raw_affiliation_string': 'Received January 4, 2000', 'institution_ids': []}, {'raw_affiliation_string': 'accepted July 5, 2000.', 'institution_ids': []}, {'raw_affiliation_string': 'Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Colleges of *Pharmacy and †Medicine, Seoul National University, Seoul, Korea', 'institution_ids': ['https://openalex.org/I139264467']}, {'raw_affiliation_string': '‡Southwest Foundation for Biomedical Research, San Antonio, Texas', 'institution_ids': ['https://openalex.org/I1289525096']}, {'raw_affiliation_string': '§Biotech Research Institute, LG Chemical Ltd., Taejon, Korea', 'institution_ids': []}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5018332997', 'https://openalex.org/A5030481456', 'https://openalex.org/A5012450211'], 'corresponding_institution_ids': ['https://openalex.org/I73616290', 'https://openalex.org/I139264467', 'https://openalex.org/I1289525096', 'https://openalex.org/I73616290', 'https://openalex.org/I139264467', 'https://openalex.org/I1289525096', 'https://openalex.org/I73616290', 'https://openalex.org/I139264467', 'https://openalex.org/I1289525096'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.238, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.831419, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '23', 'issue': '6', 'first_page': '613', 'last_page': '621'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/humanized-mouse', 'display_name': 'Humanized mouse', 'score': 0.5732317}, {'id': 'https://openalex.org/keywords/monoclonal-antibodies', 'display_name': 'Monoclonal Antibodies', 'score': 0.475793}], 'concepts': [{'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.78451777}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.76853085}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.7657794}, {'id': 'https://openalex.org/C2776946954', 'wikidata': 'https://www.wikidata.org/wiki/Q420291', 'display_name': 'Ovalbumin', 'level': 3, 'score': 0.7351316}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.7006738}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.6094685}, {'id': 'https://openalex.org/C2776156784', 'wikidata': 'https://www.wikidata.org/wiki/Q3491954', 'display_name': 'Humanized mouse', 'level': 3, 'score': 0.5732317}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.54720277}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.43700987}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4189996}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007108', 'descriptor_name': 'Immune Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D053330', 'descriptor_name': '4-1BB Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000920', 'descriptor_name': 'Antibody-Dependent Cell Cytotoxicity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007166', 'descriptor_name': 'Immunosuppressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016131', 'descriptor_name': 'Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016131', 'descriptor_name': 'Lymphocyte Subsets', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010047', 'descriptor_name': 'Ovalbumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010047', 'descriptor_name': 'Ovalbumin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010215', 'descriptor_name': 'Papio', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00002371-200011000-00002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S177451610', 'display_name': 'Journal of Immunotherapy', 'issn_l': '1524-9557', 'issn': ['1524-9557', '1537-4513'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11186149', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1498394057', 'https://openalex.org/W1524274652', 'https://openalex.org/W1533388638', 'https://openalex.org/W1545918761', 'https://openalex.org/W1582951726', 'https://openalex.org/W1596693997', 'https://openalex.org/W1635113215', 'https://openalex.org/W1656949393', 'https://openalex.org/W169058504', 'https://openalex.org/W1892298186', 'https://openalex.org/W1970483076', 'https://openalex.org/W1975060729', 'https://openalex.org/W1983072593', 'https://openalex.org/W1987930131', 'https://openalex.org/W1989053318', 'https://openalex.org/W1989194327', 'https://openalex.org/W1994942266', 'https://openalex.org/W1998006783', 'https://openalex.org/W2002507218', 'https://openalex.org/W2003896199', 'https://openalex.org/W2004159506', 'https://openalex.org/W2013165543', 'https://openalex.org/W2022234757', 'https://openalex.org/W2024084278', 'https://openalex.org/W2024281858', 'https://openalex.org/W2029249439', 'https://openalex.org/W2044166736', 'https://openalex.org/W2051870875', 'https://openalex.org/W2097765486', 'https://openalex.org/W2099241614', 'https://openalex.org/W2130011409', 'https://openalex.org/W2147051992', 'https://openalex.org/W2413768866', 'https://openalex.org/W2414969937', 'https://openalex.org/W4390469557'], 'related_works': ['https://openalex.org/W4255399293', 'https://openalex.org/W3118313920', 'https://openalex.org/W284386456', 'https://openalex.org/W2286986362', 'https://openalex.org/W2079537492', 'https://openalex.org/W2036175167', 'https://openalex.org/W2002936791', 'https://openalex.org/W1968234338', 'https://openalex.org/W1964674919', 'https://openalex.org/W1611533949'], 'abstract_inverted_index': {'The': [0], 'interaction': [1], 'of': [2, 14, 26, 61, 75, 79, 98, 114, 118, 135, 143], '4-1BB': [3, 48], 'and': [4, 52, 67, 105, 145, 148], 'its': [5], 'ligand': [6], 'plays': [7], 'an': [8], 'important': [9], 'role': [10], 'in': [11, 37, 87, 108, 179], 'the': [12, 21, 24, 46, 68, 76, 80, 136, 141, 149], 'regulation': [13], 'T-cell–mediated': [15], 'immune': [16, 35, 138, 177], 'responses.': [17], 'In': [18, 91], 'this': [19, 56], 'study,': [20], 'authors': [22], 'examined': [23], 'effect': [25], 'a': [27, 40, 58, 84, 109, 133, 170], 'humanized': [28, 59], 'anti–4-1BB': [29], 'monoclonal': [30, 42, 63], 'antibody': [31, 64, 82], '(H4B4)': [32], 'on': [33, 55], 'ovalbumin-induced': [34], 'responses': [36, 178], 'baboons.': [38], 'Previously,': [39], 'mouse': [41], 'antibody,': [43, 57, 70], '4B4': [44, 62], 'against': [45, 128], 'human': [47, 100], 'molecule,': [49], 'was': [50, 65, 131], 'generated': [51], 'characterized.': [53], 'Based': [54], 'version': [60], 'constructed': [66], 'resultant': [69], 'H4B4,': [71], 'showed': [72], 'full': [73], 'recovery': [74], 'binding': [77], 'activity': [78], 'original': [81], '4B4:': [83], '1.5-fold': [85], 'increase': [86], 'affinity': [88], 'for': [89], '4-1BB.': [90], 'addition,': [92], 'H4B4': [93, 115, 167], 'mediated': [94], 'antibody-dependent': [95], 'cellular': [96], 'cytotoxicity': [97], 'activated': [99], 'peripheral': [101], 'blood': [102], 'T': [103, 146], 'cells': [104, 107, 147], 'CEM': [106], 'dose-dependent': [110], 'manner.': [111], 'Weekly': [112], 'administration': [113], 'at': [116], 'doses': [117], '1': [119], 'or': [120], '4': [121], 'mg/kg': [122], 'could': [123], 'suppress': [124], 'immunoglobulin': [125, 151], 'G': [126, 152], 'production': [127, 153], 'ovalbumin.': [129], 'This': [130], 'not': [132, 155], 'result': [134], 'overall': [137], 'suppression,': [139], 'because': [140], 'numbers': [142], 'B': [144], 'total': [150], 'were': [154], 'altered': [156], 'during': [157], 'treatment': [158, 165], 'with': [159, 166, 181], 'H4B4.': [160], 'These': [161], 'findings': [162], 'suggest': [163], 'that': [164], 'may': [168], 'be': [169], 'valid': [171], 'therapeutic': [172], 'approach': [173], 'to': [174], 'control': [175], 'unwanted': [176], 'persons': [180], 'autoimmune': [182], 'diseases.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026927141', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-13T03:15:40.688785', 'created_date': '2016-06-24'}