Publication Information

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596, 2667, 2704, 3178], 'into': [15, 187, 788, 1238, 1896, 1986, 2100, 3222], 'the': [16, 97, 110, 122, 150, 165, 188, 269, 282, 294, 322, 337, 361, 404, 468, 580, 681, 687, 708, 741, 751, 784, 864, 938, 973, 1026, 1063, 1191, 1201, 1234, 1357, 1420, 1423, 1431, 1590, 1704, 1786, 1810, 1827, 1833, 1856, 1892, 1966, 1980, 2024, 2109, 2121, 2167, 2213, 2228, 2236, 2308, 2343, 2397, 2485, 2493, 2585, 2642, 2727, 2736, 2826, 2842, 2856, 2863, 2867, 2936, 2944, 3089, 3198, 3244, 3344, 3393, 3401, 3435, 3473, 3479, 3510, 3644, 3712, 3824, 3915, 3937, 4019, 4028], 'lipid': [17, 189, 469, 2122, 3216, 3268, 3661], 'mediator': [18, 190, 470, 1476, 2123], 'lysophosphatidic': [19, 191, 471, 500, 557, 611, 781, 1231, 1261, 1306, 1394, 1542, 1591, 1623, 1889, 1940, 2536, 2793, 2884, 3066, 3123, 3158, 3248, 3371, 3429, 3591, 3621, 4124, 4181], 'acid': [20, 192, 472, 558, 612, 753, 1004, 1203, 1262, 1307, 1395, 1472, 1543, 1592, 1624, 2222, 2572, 2794, 2860, 2885, 3067, 3124, 3159, 3353, 3368, 3372, 3430, 3535, 3622, 4058, 4182], '(LPA),': [21, 193], 'ligand': [23, 195, 2340], 'for': [24, 33, 196, 205, 610, 967, 1120, 1422, 1791, 2120, 2284, 2302, 2739, 2752, 2820, 2883, 2989, 3009, 3267, 3829, 3836, 4195], 'specific': [25, 197, 844], 'G': [26, 198, 845], 'protein-coupled': [27, 199, 846], 'receptors.': [28, 200], 'ATX-LPA': [29, 201, 1115, 1963, 3881], 'signaling': [30, 136, 202, 308, 852, 920, 1116, 1504, 2010, 2055, 2373, 2946, 3074, 3882], 'essential': [32, 204, 1119], 'development': [34, 166, 206, 338, 1124, 1432, 2025, 2915, 2951, 2970], 'and': [35, 54, 65, 102, 135, 138, 157, 207, 226, 237, 274, 307, 310, 329, 387, 452, 554, 576, 593, 600, 694, 860, 901, 927, 944, 1010, 1043, 1049, 1059, 1100, 1122, 1150, 1160, 1266, 1320, 1433, 1493, 1501, 1541, 1549, 1597, 1666, 1695, 1725, 1861, 1866, 1937, 1982, 1989, 2009, 2012, 2031, 2049, 2053, 2081, 2141, 2201, 2215, 2241, 2270, 2380, 2393, 2434, 2499, 2515, 2612, 2627, 2674, 2731, 2790, 2984, 3068, 3072, 3088, 3095, 3117, 3176, 3182, 3302, 3322, 3431, 3517, 3587, 3623, 3663, 3667, 3672, 3696, 3719, 3759, 3860, 3911, 3925, 3933, 3972, 3977, 3984, 4030, 4046, 4082, 4094, 4178], 'has': [36, 113, 208, 285, 545, 1151, 1798, 2781, 4169], 'been': [37, 209, 951, 1152], 'implicated': [38, 210, 1153], 'in': [39, 211, 380, 427, 686, 703, 1126, 1137, 1154, 1430, 1505, 1600, 1625, 1785, 1961, 2184, 2212, 2349, 2497, 2538, 2584, 2610, 2634, 2641, 2723, 2862, 2940, 3003, 3250, 3271, 3373, 3400, 3509, 3549, 3742, 3822, 4018, 4198], 'great': [41, 213, 1156], 'diversity': [42, 214], 'of': [43, 100, 117, 131, 167, 170, 215, 272, 289, 303, 339, 342, 368, 455, 494, 579, 649, 744, 786, 821, 839, 863, 918, 940, 1012, 1028, 1062, 1158, 1194, 1236, 1269, 1359, 1390, 1435, 1477, 1539, 1587, 1589, 1622, 1670, 1727, 1757, 1826, 1836, 1852, 1894, 1932, 1969, 2004, 2026, 2029, 2139, 2172, 2217, 2219, 2235, 2342, 2370, 2396, 2456, 2530, 2570, 2587, 2606, 2666, 2701, 2703, 2747, 2852, 2858, 2866, 3031, 3200, 3243, 3273, 3425, 3428, 3437, 3472, 3482, 3498, 3512, 3546, 3551, 3590, 3617, 3647, 3678, 3788, 3796, 3819, 3827, 3853, 3868, 3880, 3889, 3906, 3919, 3936, 4049, 4074, 4118], '(patho)physiological': [44, 216], 'processes,': [45, 217, 1162], 'ranging': [46, 218], 'from': [47, 219, 475, 1041, 2484, 3045, 3092, 3392, 3434, 4091], 'lymphocyte': [48, 220, 714, 738, 822, 1164, 1188], 'homing': [49, 221, 1165], 'to': [50, 70, 121, 145, 149, 155, 222, 242, 293, 317, 321, 327, 360, 550, 655, 935, 1031, 1046, 1313, 1356, 2016, 2108, 2166, 2509, 2513, 2582, 2649, 2668, 2754, 2786, 3179, 3190, 3197, 3565, 3620, 3857, 3895, 4011, 4097, 4100, 4174], 'tumor': [51, 223, 551, 1013, 1494, 2787, 4175], 'progression.': [52, 224], 'Structural': [53, 225, 2699], 'functional': [55, 227], 'studies': [56, 228, 1977], 'have': [57, 229, 949, 1971, 1978, 3715, 4076], 'revealed': [58, 230, 2460], 'what': [59, 231, 1990, 3191], 'makes': [60, 232, 1991], 'ATX': [61, 68, 75, 132, 140, 233, 240, 247, 304, 312, 466, 676, 698, 1774, 1781, 1797, 1854, 1868, 1970, 1987, 1992, 2005, 2014, 2030, 2753, 2840, 2986, 3457, 3666, 3722, 3816, 3828, 3854, 3869, 3890, 4075], 'unique': [63, 235, 1994], 'lysoPLD,': [64, 236, 3726], 'how': [66, 139, 238, 311, 2013], 'binds': [69, 241, 2015], 'its': [71, 243, 1641, 2017, 2202, 3668], 'target': [72, 146, 244, 318, 3121], 'cells.': [73, 245, 2019], 'The': [74, 246, 364, 836, 915, 930, 1114, 1753, 2103, 2664, 2929, 3170, 3496, 3878, 3900, 4080], 'catalytic': [76, 111, 248, 283, 374, 3688, 3720], 'domain': [77, 112, 249, 284, 3691, 3701], 'shows': [78, 250], 'characteristic': [80, 252], 'bimetallic': [81, 253], 'active': [82, 123, 254, 295, 1701, 3246], 'site': [83, 255], 'followed': [84, 256], 'by': [85, 103, 257, 275, 556, 750, 1200, 1316, 1809, 1832, 2258, 2461, 2480, 2491, 2705, 2792, 2870, 2916, 2971, 3040, 3126, 3214, 3350, 3395, 3478, 3504, 3541, 3626, 3652, 3886, 3914, 3922, 4180], 'shallow': [87, 259], 'binding': [88, 154, 260, 326, 2033, 2577, 2665, 3564, 3586], 'groove': [89, 261], 'can': [91, 263, 2097, 2255, 2383, 2477, 2629, 3036], 'accommodate': [92, 264], 'nucleotides': [93, 265, 3821, 3837], 'as': [94, 96, 266, 268, 348, 503, 598, 1038, 1645, 1689, 1699, 1761, 1799, 1804, 2275, 2574, 2625, 2631, 2735, 3454, 3724, 3793, 3873, 4013, 4127], 'well': [95, 267], 'glycerol': [98, 270, 2237], 'moiety': [99, 271], 'lysophospholipids,': [101, 273, 386], 'deep': [105, 277], 'lipid-binding': [106, 278], 'pocket.': [107, 279], 'In': [108, 280, 1996, 3204, 3339, 3641, 3847], 'addition,': [109, 281], 'an': [114, 286, 777, 1227, 1646, 1700, 1885], 'open': [115, 287], 'tunnel': [116, 288], 'unknown': [118, 290], 'function': [119, 291, 451], 'adjacent': [120, 292], 'site.': [124, 296], 'Here,': [125, 297], 'we': [126, 298, 1999], 'discuss': [127, 164, 299, 336, 2000, 2023], 'our': [128, 300, 2001], 'current': [129, 301, 2002], 'understanding': [130, 302, 1962, 2003], 'structure-function': [133, 305, 2006], 'relationships': [134, 306], 'mechanisms,': [137, 309, 2011], 'isoforms': [141, 313, 2008, 3897], 'use': [142, 314], 'distinct': [143, 315, 2039, 2054, 3896], 'mechanisms': [144, 316], 'LPA': [147, 319, 656, 919, 923, 936, 963, 1032, 1502, 1794, 2035, 2095, 2159, 2187, 2200, 2253, 2267, 2298, 2371, 2457, 2474, 2756, 2816, 2853, 3035, 3194, 3210, 3221, 3347, 3388, 3499, 3514, 3552, 3649, 3858, 4196], 'production': [148, 320, 657, 2854, 3195, 3859, 4197], 'plasma': [151, 323, 496, 1793, 1853, 1939, 2498, 2607, 2868, 3566, 3627, 4101, 4120], 'membrane,': [152, 324], 'notably': [153, 325, 3043], 'integrins': [156, 328], 'heparan': [158, 330], 'sulfate': [159, 331], 'proteoglycans.': [160, 332], 'We': [161, 333, 2020], 'also': [162, 334, 346, 701, 950, 1783, 2021, 2244, 2512, 3037, 3501, 3569], 'briefly': [163, 335, 2022], 'drug-like': [168, 340], 'inhibitors': [169, 341, 2028], 'ATX.': [171, 343, 2740], 'known': [347, 932, 3850, 3903], 'pyrophosphatase/phosphodiesterase': [350, 3790], '(ENPP)2,': [351], 'belongs': [359], 'ENPP': [362, 365], 'family.': [363], 'family': [366, 2171, 2186], 'consists': [367], 'seven': [369], 'members': [370], 'with': [371, 680, 2261, 2637, 2651, 2726, 2742, 4055], 'structurally': [372], 'related': [373, 2165, 3432], 'domains': [375, 4032], 'hydrolyze': [377, 3173, 3763], 'phosphodiester': [378], 'bonds': [379], 'various': [381, 2207, 3177], 'substrates,': [382, 3660], 'including': [383, 1163], 'nucleoside': [384], 'triphosphates,': [385], 'choline': [388, 2482], 'phosphate': [389, 1426, 3217, 3269, 3299, 3320], 'esters': [390], '(1Bollen': [391], 'M.': [392, 423, 447, 524, 818, 954, 1293, 1378, 1520, 1522, 1578, 1584, 1619, 1722, 1752, 1815, 1823, 2289, 2554, 2556, 2564, 2598, 2604, 2698, 2760, 2807, 3001, 3289, 3356, 3409, 3411, 3461, 3469, 3738, 3953, 4148], 'Gijsbers': [393], 'R.': [394, 767, 769, 1000, 1217, 1219, 1382, 1617, 1875, 1877, 1910, 2451, 2999], 'Ceulemans': [395], 'H.': [396, 445, 765, 804, 1215, 1388, 1819, 1873, 2906, 2961, 3054, 3287, 3366, 3465, 3533, 3576, 3767], 'Stalmans': [397, 1719], 'W.': [398, 1453, 1526, 1720, 2332], 'Stefan': [399, 1710], 'C.': [400, 419, 1341, 1469, 1711, 1912, 1920, 2449, 2696, 2997, 3318, 3611, 3734], 'Nucleotide': [401], 'pyrophosphatases/phosphodiesterases': [402], 'on': [403, 843, 922, 1595, 2037, 2377, 2458, 2935, 3343], 'move.Crit.': [405], 'Rev.': [406, 828, 904, 1103, 1508, 2084, 2148, 2437], 'Biochem.': [407, 429, 3744, 4060], 'Mol.': [408, 1365], 'Biol.': [409, 508, 561, 1366, 1439, 1676, 2353, 2797, 3076, 3129, 3593, 3800, 3987, 4132, 4185], '2000;': [410, 2615, 3595], '35:': [411], '393-432Crossref': [412], 'PubMed': [413, 439, 461, 518, 565, 588, 619, 671, 759, 796, 833, 872, 910, 981, 1020, 1071, 1109, 1145, 1209, 1246, 1277, 1327, 1370, 1402, 1488, 1512, 1560, 1609, 1633, 1684, 1740, 1769, 1845, 1904, 1952, 2090, 2152, 2195, 2316, 2363, 2405, 2443, 2468, 2546, 2592, 2618, 2680, 2713, 2801, 2834, 2892, 2924, 2979, 3023, 3085, 3139, 3165, 3257, 3281, 3310, 3334, 3380, 3449, 3491, 3558, 3603, 3636, 3754, 3810, 3945, 3997, 4064, 4142, 4189], 'Scopus': [414, 440, 462, 519, 566, 589, 620, 672, 760, 797, 873, 911, 982, 1021, 1072, 1110, 1146, 1210, 1247, 1278, 1328, 1371, 1403, 1442, 1489, 1513, 1561, 1610, 1634, 1741, 1770, 1846, 1905, 1953, 2091, 2153, 2196, 2317, 2364, 2406, 2444, 2469, 2547, 2593, 2619, 2681, 2714, 2802, 2835, 2893, 2925, 2980, 3024, 3140, 3166, 3258, 3282, 3311, 3335, 3381, 3450, 3492, 3559, 3604, 3637, 3755, 3811, 3946, 3998, 4065, 4143, 4190], '(255)': [415], 'Google': [416, 442, 464, 521, 568, 591, 622, 674, 762, 799, 834, 875, 913, 984, 1023, 1074, 1112, 1148, 1212, 1249, 1280, 1330, 1373, 1405, 1444, 1491, 1515, 1563, 1612, 1636, 1685, 1743, 1772, 1848, 1907, 1955, 2093, 2155, 2198, 2319, 2366, 2408, 2446, 2471, 2549, 2595, 2621, 2683, 2716, 2804, 2837, 2895, 2927, 2982, 3026, 3086, 3142, 3168, 3260, 3284, 3313, 3337, 3383, 3452, 3494, 3561, 3606, 3639, 3757, 3813, 3948, 4000, 4067, 4145, 4192], 'Scholar,': [417, 443, 522, 569, 623, 763, 800, 876, 985, 1075, 1213, 1250, 1331, 1516, 1564, 1613, 1744, 1908, 2320, 2409, 2447, 2550, 2596, 2684, 2805, 2896, 3143, 3261, 3285, 3314, 3607, 3949, 4146], '2Stefan': [418], 'Jansen': [420, 3735], 'S.': [421, 607, 629, 631, 810, 1518, 1530, 1709, 1746, 1813, 1914, 2134, 2181, 2686, 2880, 3145, 3459, 3736, 3775, 3781, 3785, 4036], 'Bollen': [422, 1721, 1822, 3468, 3737], 'NPP-type': [424, 3739], 'ectophosphodiesterases:': [425, 3740], 'unity': [426, 3741], 'diversity.Trends': [428, 3743], 'Sci.': [430, 1736, 3745], '2005;': [431, 1737, 3162, 3746], '30:': [432, 1510, 2922, 2977, 3747], '542-550Abstract': [433, 3748], 'Full': [434, 436, 513, 515, 666, 668, 1483, 1485, 1555, 1557, 1681, 1947, 1949, 2358, 2360, 3018, 3020, 3080, 3082, 3134, 3136, 3329, 3331, 3444, 3446, 3598, 3600, 3749, 3751, 3805, 3807, 3992, 3994, 4137, 4139], 'Text': [435, 437, 514, 516, 667, 669, 1484, 1486, 1556, 1558, 1682, 1948, 1950, 2359, 2361, 3019, 3021, 3081, 3083, 3135, 3137, 3330, 3332, 3445, 3447, 3599, 3601, 3750, 3752, 3806, 3808, 3993, 3995, 4138, 4140], 'PDF': [438, 517, 670, 1487, 1559, 1683, 1951, 2362, 3022, 3084, 3138, 3333, 3448, 3602, 3753, 3809, 3996, 4141], '(302)': [441, 3756], '3Zimmermann': [444], 'Zebisch': [446], 'Strater': [448], 'N.': [449, 532, 1333, 2600, 2768, 2900, 2955, 3957, 4156], 'Cellular': [450], 'molecular': [453, 2208], 'structure': [454], 'ecto-nucleotidases.Purinergic': [456], 'Signal.': [457], '2012;': [458, 1274, 1367, 1606, 4061], '8:': [459, 3078], '437-502Crossref': [460], '(721)': [463], 'Scholar).': [465, 675, 835, 914, 1024, 1113, 1637, 1773, 1849, 1956, 2094, 2156, 2199, 2367, 2472, 2622, 2838, 2928, 3027, 3169, 3338, 3384, 3495, 3562, 3640, 3814, 4001], 'produces': [467, 780, 1230, 1888, 2534], '(LPA;': [473], 'mono-acyl-glycerol-3-phosphate)': [474], 'lysophosphatidylcholine': [477], '(LPC)': [478], '(4Tokumura': [479, 4103], 'A.': [480, 528, 605, 723, 735, 814, 958, 994, 1173, 1185, 1337, 1345, 1657, 1718, 1821, 1918, 2293, 2519, 2602, 2764, 2811, 2878, 2898, 2953, 2995, 3415, 3467, 3771, 3951, 4104, 4152], 'Majima': [481, 4105], 'E.': [482, 721, 731, 802, 956, 1171, 1181, 1339, 1661, 1715, 1916, 2291, 2809, 4106], 'Kariya': [483, 4107], 'Y.': [484, 526, 727, 733, 771, 991, 1177, 1183, 1221, 1252, 1524, 1879, 2177, 2338, 2521, 2762, 3358, 3360, 3362, 3417, 3529, 3779, 4042, 4108, 4150], 'Tominaga': [485, 4109], 'K.': [486, 488, 490, 492, 530, 534, 540, 725, 816, 882, 960, 1081, 1175, 1748, 1817, 2062, 2175, 2295, 2415, 2527, 2558, 2766, 2770, 2776, 2813, 3056, 3463, 3525, 3527, 3773, 3777, 3783, 4038, 4040, 4110, 4112, 4114, 4116, 4154, 4158, 4164], 'Kogure': [487, 4111], 'Yasuda': [489, 4113], 'Fukuzawa': [491, 2526, 4115], 'Identification': [493, 2569, 4045, 4117], 'human': [495, 2350, 2611, 2706, 3973, 4119], 'D,': [498, 4122], 'acid-producing': [501, 4125], 'enzyme,': [502, 4126], 'autotaxin,': [504, 1671, 4128], 'multifunctional': [506, 4130], 'phosphodiesterase.J.': [507, 4131], 'Chem.': [509, 1677, 2354, 3130, 3594, 3801, 3988, 4133], '2002;': [510, 562, 2798, 3278, 3555, 4134, 4186], '277:': [511, 4135], '39436-39442Abstract': [512, 4136], '(610)': [520, 4144], '5Umezu-Goto': [523, 4147], 'Kishi': [525, 2761, 3357, 4149], 'Taira': [527, 2763, 4151], 'Hama': [529, 2765, 4039, 4153], 'Dohmae': [531, 2767, 4155], 'Takio': [533, 2769, 4157], 'Yamori': [535, 2771, 4159], 'T.': [536, 643, 888, 996, 1087, 1750, 2068, 2130, 2179, 2421, 2560, 2772, 3578, 4034, 4160], 'Mills': [537, 2773, 4161], 'G.B.': [538, 2774, 4162], 'Inoue': [539, 604, 2775, 2877, 4163], 'Aoki': [541, 2777, 2907, 2962, 3363, 3530, 4043, 4165], 'J.': [542, 603, 1299, 1362, 1386, 1465, 1467, 1570, 2128, 2525, 2568, 2614, 2676, 2709, 2778, 2876, 2902, 2908, 2920, 2957, 2963, 2975, 3161, 3232, 3364, 3531, 3629, 4044, 4166], 'et': [543, 644, 736, 897, 1096, 1186, 1304, 1470, 1537, 1585, 2077, 2430, 2779, 3786, 3970, 4167], 'al.Autotaxin': [544, 2780, 4168], 'activity': [548, 648, 1621, 1644, 2784, 4172], 'leading': [549, 2785, 4173], 'cell': [552, 941, 1008, 2788, 4176], 'growth': [553, 2789, 4177], 'motility': [555, 1648, 2791, 4179], 'production.J.': [559, 2795, 4183], 'Cell': [560, 1364, 1735, 2796, 3631, 4184], '158:': [563, 2799, 4187], '227-233Crossref': [564, 2800, 4188], '(793)': [567, 2803, 4191], '6van': [570], 'Meeteren': [571, 855, 1054, 1134, 1922, 2388, 3100, 3928], 'L.A.': [572, 856, 1055, 1135, 1663, 1923, 2389, 3101, 3929], 'Moolenaar': [573, 857, 961, 1056, 1498, 1924, 2135, 2296, 2390, 2452, 2814, 3060, 3114, 3236, 3930], 'W.H.': [574, 858, 962, 1057, 1128, 1499, 1925, 2136, 2297, 2391, 2453, 2815, 3061, 3115, 3237, 3931], 'Regulation': [575, 859, 1058, 2392, 3932], 'biological': [577, 861, 902, 916, 1029, 1060, 1101, 2082, 2381, 2394, 2435, 3542, 3851, 3934], 'activities': [578, 862, 1045, 1061, 2395, 3935], 'autotaxin-LPA': [581, 865, 1064, 2398, 3938], 'axis.Prog.': [582, 866, 1065, 2399, 3939], 'Lipid': [583, 661, 867, 1066, 1942, 2400, 3298, 3319, 3324, 3439, 3940], 'Res.': [584, 662, 868, 1016, 1067, 1943, 2401, 3325, 3440, 3941], '2007;': [585, 869, 1068, 2402, 3633, 3942], '46:': [586, 870, 1069, 2403, 3943], '145-160Crossref': [587, 871, 1070, 2404, 3944], '(296)': [590, 874, 1073, 2407, 3947], 'Scholar)': [592, 3087, 4068], 'other': [594, 3345], '(non-choline)': [595], 'such': [597, 2624], 'lysophosphatidylethanolamine': [599, 2628], 'lysophosphatidylserine': [601], '(7Aoki': [602, 2875], 'Okudaira': [606, 2879, 4035], 'Two': [608, 2881], 'pathways': [609, 853, 2882], 'production.Biochim.': [613, 2886], 'Biophys.': [614, 1140, 1628, 2190, 2541, 2887, 3252, 3276, 3305], 'Acta.': [615, 1141, 1629, 2191, 2542, 2888, 3253, 3277, 3306], '2008;': [616, 793, 1243, 1324, 1901, 2465, 2889, 3989], '1781:': [617, 2890], '513-518Crossref': [618, 2891], '(347)': [621, 2894], '8Bolen': [624], 'A.L.': [625, 2324, 2334], 'Naren': [626], 'A.P.': [627], 'Yarlagadda': [628], 'Beranova-Giorgianni': [630], 'Chen': [632, 1253, 2691], 'L.': [633, 719, 808, 1169, 2692, 2993], 'Norman': [634], 'D.': [635, 1349, 1582, 3293], 'Baker': [636], 'D.L.': [637], 'Rowland': [638], 'M.M.': [639], 'Best': [640], 'M.D.': [641, 773, 1223, 1881], 'Sano': [642], 'al.The': [645, 1305], 'phospholipase': [646, 2872, 3063, 3154], 'A1': [647, 2873], 'A-I': [651], 'links': [652, 1310], 'platelet': [653, 2351], 'activation': [654, 1009, 1052, 1726, 2758, 3550], 'during': [658], 'blood': [659], 'coagulation.J.': [660], '2011;': [663, 830, 978, 1509, 1944, 2313, 2831, 2921, 2976], '52:': [664, 1945], '958-970Abstract': [665], '(45)': [673], 'widely': [678], 'expressed,': [679], 'highest': [682], 'mRNA': [683], 'levels': [684, 1871, 3842], 'detected': [685], 'brain,': [688], 'spinal': [689], 'cord,': [690], 'ovary,': [691], 'lung,': [692], 'intestine,': [693], 'kidney.': [695], 'Relatively': [696], 'high': [697, 709, 745, 825, 1195, 1858, 1870], 'expression': [699, 1354], 'found': [702, 2385, 4096], 'lymph': [704], 'nodes,': [705], 'specifically': [706], 'at': [707, 1869, 2227], 'endothelial': [710, 746, 826, 1196, 1839, 1859, 3404, 3485], 'venules': [711, 747, 1197, 1860], 'control': [713, 1011], 'entry': [715, 785, 1235, 1893], '(9Bai': [716, 1166], 'Z.': [717, 806, 1167, 1295], 'Cai': [718, 807, 1168], 'Umemoto': [720, 1170], 'Takeda': [722, 813, 1172], 'Tohya': [724, 815, 1174], 'Komai': [726, 1176], 'Veeraveedu': [728, 1178], 'P.T.': [729, 1179], 'Hata': [730, 1180], 'Sugiura': [732, 1182], 'Kubo': [734, 1184], 'al.Constitutive': [737, 1187], 'transmigration': [739, 1189], 'across': [740, 824, 1190], 'basal': [742, 1192], 'lamina': [743, 1193], 'regulated': [749, 1199, 3503], 'autotaxin/lysophosphatidic': [752, 1202], 'axis.J.': [754, 1204], 'Immunol.': [755, 792, 829, 1015, 1205, 1242, 1273, 1900], '2013;': [756, 1017, 1142, 1206, 1630, 2192, 3015, 3307, 3441, 3802], '190:': [757, 1207], '2036-2048Crossref': [758, 1208], '(81)': [761, 1211], '10Kanda': [764, 1214], 'Newton': [766, 1216, 1874], 'Klein': [768, 1218, 1876], 'Morita': [770, 1220, 1878], 'Gunn': [772, 1222, 1880], 'Rosen': [774, 1224, 1257, 1882], 'S.D.': [775, 1225, 1258, 1883], 'Autotaxin,': [776, 1226, 1884], 'ectoenzyme': [778, 1228, 1886], 'acid,': [782, 1232, 1890, 3249], 'promotes': [783, 1233, 1891], 'lymphocytes': [787, 1237, 1895], 'secondary': [789, 1239, 1897], 'lymphoid': [790, 1240, 1898], 'organs.Nat.': [791, 1241, 1899], '9:': [794, 1244, 1902, 2466], '415-423Crossref': [795, 1245, 1903], '(211)': [798, 1248, 1906], '11Umemoto': [801], 'Hayasaka': [803], 'Bai': [805], 'Yonekura': [809], 'Peng': [811], 'X.': [812, 1534, 2688], 'Miyasaka': [817], 'Novel': [819], 'regulators': [820], 'trafficking': [823], 'venules.Crit.': [827], '31:': [831], '147-169Crossref': [832], 'bioactive': [837, 2535, 3034, 3183], 'product': [838], 'ATX,': [840, 1638, 3657, 3907], 'LPA,': [841, 3184], 'acts': [842, 1775, 2036, 2933], 'receptors': [847, 1544, 1835, 2096, 2106, 2160, 2254, 2268, 3125, 3481, 3523, 3537], '(GPCRs)': [848], 'activate': [850], 'multiple': [851], '(6van': [854, 1053, 2387, 3927], '12Choi': [877, 1076, 2410], 'J.W.': [878, 1077, 1568, 1713, 2058, 2411], 'Herr': [879, 1078, 2059, 2412], 'D.R.': [880, 1079, 2060, 2413], 'Noguchi': [881, 1080, 2061, 2414], 'Yung': [883, 1082, 2063, 2416], 'Y.C.': [884, 1083, 1254, 2064, 2417], 'Lee': [885, 1084, 1131, 2065, 2418, 3575], 'C.W.': [886, 1085, 2066, 2419, 3582], 'Mutoh': [887, 1086, 2067, 2420], 'Lin': [889, 1088, 2069, 2422], 'M.E.': [890, 1089, 2070, 2423], 'Teo': [891, 1090, 2071, 2424], 'S.T.': [892, 1091, 2072, 2425], 'Park': [893, 1092, 2073, 2426, 3768], 'K.E.': [894, 1093, 2074, 2427], 'Mosley': [895, 1094, 2075, 2428], 'A.N.': [896, 1095, 2076, 2429], 'al.LPA': [898, 1097, 2078, 2431], 'receptors:': [899, 1098, 2079, 2432], 'subtypes': [900, 1099, 2080, 2433], 'actions.Annu.': [903, 1102, 2083, 2436], 'Pharmacol.': [905, 1104, 2085, 2438], 'Toxicol.': [906, 1105, 2086, 2439], '2010;': [907, 1106, 1480, 2087, 2149, 2440], '50:': [908, 1107, 2088, 2441, 3327], '157-186Crossref': [909, 1108, 2089, 2442], '(649)': [912, 1111, 2092, 2445], 'outcome': [917], 'depends': [921], 'receptor': [924, 1033, 1308, 1396, 1503, 1593, 1964, 2169, 2188, 2346, 2372, 2757, 3862], '(co-)expression': [925], 'patterns': [926], 'tissue': [928, 3982], 'context.': [929], 'best': [931, 3902], 'cellular': [933, 3122, 3206, 3274, 3588, 3618], 'responses': [934, 948, 1030, 3619], 'include': [937], 'stimulation': [939, 1034], 'migration,': [942], 'proliferation,': [943], 'survival,': [945], 'but': [946, 2246, 2511, 2848, 3520], 'inhibitory': [947], 'documented': [952], '(13Jongsma': [953, 2288], 'Matas-Rico': [955, 2290, 2808], 'Rzadkowski': [957, 2292, 2810], 'Jalink': [959, 2294, 2812, 3055], 'chemorepellent': [966, 2301, 2819], 'B16': [968, 2303, 2821], 'melanoma': [969, 2304, 2822], 'cells:': [970, 2305, 2823], 'action': [971, 2306, 2824], 'through': [972, 1260, 2307, 2825], 'cAMP-elevating': [974, 2309, 2827], 'LPA5': [975, 2279, 2310, 2828], 'receptor.PLoS': [976, 2311, 2829], 'ONE.': [977, 2312, 2830], '6:': [979, 2314, 2832], 'e29260Crossref': [980, 2315, 2833], '(60)': [983, 2318, 2836], '14Oda': [986], 'S.K.': [987], 'Strauch': [988], 'P.': [989, 1287, 1412, 1927, 2326, 2566, 3291, 3413, 3961, 3965], 'Fujiwara': [990, 2337], 'Al': [992], 'Shami': [993], 'Oravecz': [995], 'Tigyi': [997, 2335], 'G.': [998, 1343, 1536, 2336], 'Pelanda': [999], 'Torres': [1001], 'R.M.': [1002], 'Lysophosphatidic': [1003, 3534], 'inhibits': [1005], 'CD8': [1006], 'T': [1007, 1271], 'progression.Cancer': [1014], '1:': [1018], '245-255Crossref': [1019], '(54)': [1022], 'However,': [1025, 3864, 4071], 'list': [1027], 'remarkably': [1036], 'diverse,': [1037], 'it': [1039, 1789, 1805, 2505, 4014], 'ranges': [1040], 'mitogenic': [1042], 'chemotactic': [1044], 'neurite': [1047], 'remodeling': [1048], 'ion': [1050], 'channel': [1051], 'axis': [1117, 2947], 'vascular': [1121, 1321, 3303], 'neural': [1123], '[reviewed': [1125], '(15Moolenaar': [1127], 'Houben': [1129], 'A.J.': [1130, 1418, 1497, 3265, 3295, 3423], 'S.J.': [1132, 3109], 'van': [1133, 1458, 1461, 1921, 3057, 3233, 3238], 'embryonic': [1138], 'development.Biochim.': [1139, 3304], '1831:': [1143, 1631, 2193, 3308], '13-19Crossref': [1144], '(44)': [1147], 'Scholar)]': [1149], 'variety': [1157], 'physiological': [1159, 2737, 3718], 'pathological': [1161], '16Zhang': [1251], 'Krummel': [1255], 'M.F.': [1256, 3107], 'stimulates': [1263], 'polarization,': [1264], 'motility,': [1265], 'transendothelial': [1267], 'migration': [1268], 'naive': [1270], 'cells.J.': [1272], '189:': [1275], '3914-3924Crossref': [1276], '(70)': [1279, 2197], 'Scholar),': [1281, 1374, 1406, 1445, 1492, 1686, 2983, 3453, 3758, 4193], 'pulmonary': [1282, 1311, 1360], 'fibrosis': [1283, 1312], '(17Tager': [1284], 'A.M.': [1285], 'LaCamera': [1286], 'Shea': [1288], 'B.S.': [1289], 'Campanella': [1290], 'G.S.': [1291], 'Selman': [1292], 'Zhao': [1294], 'Polosukhin': [1296], 'V.': [1297, 1351, 1659], 'Wain': [1298], 'Karimi-Shah': [1300], 'B.A.': [1301], 'Kim': [1302], 'N.D.': [1303], 'LPA1': [1309, 3516], 'lung': [1314], 'injury': [1315], 'mediating': [1317], 'fibroblast': [1318], 'recruitment': [1319], 'leak.Nat.': [1322], 'Med.': [1323, 1398], '14:': [1325], '45-54Crossref': [1326], '(585)': [1329], '18Oikonomou': [1332], 'Mouratis': [1334], 'M.A.': [1335], 'Tzouvelekis': [1336], 'Kaffe': [1338], 'Valavanis': [1340], 'Vilaras': [1342], 'Karameris': [1344], 'Prestwich': [1346, 2903, 2958], 'G.D.': [1347, 2904, 2959], 'Bouros': [1348], 'Aidinis': [1350], 'Pulmonary': [1352], 'autotaxin': [1353, 1540, 1728, 1758, 1831, 1933, 3477, 3974, 4052], 'contributes': [1355, 3196], 'pathogenesis': [1358], 'fibrosis.Am.': [1361], 'Respir.': [1363], '47:': [1368], '566-574Crossref': [1369], '(171)': [1372], 'neuropathic': [1375, 1391], 'pain': [1376, 1392], '(19Inoue': [1377], 'Rashid': [1379], 'M.H.': [1380], 'Fujita': [1381], 'Contos': [1383], 'J.J.': [1384, 1451], 'Chun': [1385], 'Ueda': [1387], 'Initiation': [1389], 'requires': [1393], 'signaling.Nat.': [1397], '2004;': [1399, 3131, 3377], '10:': [1400], '712-718Crossref': [1401], '(426)': [1404], 'cardiovascular': [1407], 'disease': [1408], '(20Smyth': [1409], 'S.S.': [1410, 3297, 3421], 'Mueller': [1411, 3290, 3412], 'Yang': [1413, 2689], 'F.': [1414, 1455, 1528, 1580, 2690, 3052, 3103, 3959], 'Brandon': [1415], 'J.A.': [1416, 3969], 'Morris': [1417, 3264, 3294, 3422], 'Arguing': [1419], 'case': [1421], 'autotaxin-lysophosphatidic': [1424], 'acid-lipid': [1425], 'phosphatase': [1427, 3300, 3354, 3369], '3-signaling': [1428], 'nexus': [1429], 'complications': [1434], 'atherosclerosis.Arterioscler': [1436], 'Thromb': [1437], 'Vasc': [1438], '2014;': [1440], 'Crossref': [1441], '(47)': [1443], 'cholestatic': [1446, 1478], 'pruritus': [1447], '(21Kremer': [1448], 'A.E.': [1449, 2659], 'Martens': [1450], 'Kulik': [1452], 'Rueff': [1454], 'Kuiper': [1456], 'E.M.': [1457], 'Buuren': [1459], 'H.R.': [1460], 'Erpecum': [1462], 'K.J.': [1463], 'Kondrackiene': [1464], 'Prieto': [1466], 'Rust': [1468], 'al.Lysophosphatidic': [1471], 'potential': [1475], 'pruritus.Gastroenterology.': [1479], '139:': [1481], '1008-1018Abstract': [1482], '(295)': [1490], 'progression': [1495], '(22Houben': [1496], 'cancer.Cancer': [1506], 'Metastasis': [1507], '557-565Crossref': [1511], '(193)': [1514], '23Liu': [1517], 'Umezu-Goto': [1519], 'Murph': [1521], 'Lu': [1523], 'Liu': [1525], 'Zhang': [1527], 'Yu': [1529], 'Stephens': [1531], 'L.C.': [1532], 'Cui': [1533], 'Murrow': [1535], 'al.Expression': [1538], 'increases': [1545], 'mammary': [1546], 'tumorigenesis,': [1547], 'invasion,': [1548], 'metastases.Cancer': [1550], 'Cell.': [1551], '2009;': [1552, 1842, 2355, 2710, 3326, 3488], '15:': [1553], '539-550Abstract': [1554], '(311)': [1562], '24Marshall': [1565], 'J.C.': [1566], 'Collins': [1567], 'Nakayama': [1569], 'Horak': [1571], 'C.E.': [1572], 'Liewehr': [1573], 'D.J.': [1574, 1734], 'Steinberg': [1575], 'S.M.': [1576], 'Albaugh': [1577], 'Vidal-Vanaclocha': [1579], 'Palmieri': [1581], 'Barbier': [1583], 'al.Effect': [1586], 'inhibition': [1588], '1': [1594], 'metastasis': [1596], 'metastatic': [1598, 1829, 3475], 'dormancy': [1599], 'breast': [1601], 'cancer.J.': [1602], 'Natl.': [1603], 'Cancer': [1604], 'Inst.': [1605], '104:': [1607], '1306-1319Crossref': [1608], '(100)': [1611], '25Peyruchaud': [1614], 'O.': [1615, 2523], 'Leblanc': [1616], 'David': [1618], 'Pleiotropic': [1620], 'bone': [1626], 'metastasis.Biochim.': [1627], '99-104Crossref': [1632], '(29)': [1635], 'named': [1639], 'after': [1640, 1693], 'first': [1642], 'discovered': [1643], '"autocrine': [1647], 'factor"': [1649], '(26Stracke': [1650], 'M.L.': [1651], 'Krutzsch': [1652], 'H.C.': [1653], 'Unsworth': [1654], 'E.J.': [1655, 2694, 3235, 3574], 'Arestad': [1656], 'Cioce': [1658], 'Schiffmann': [1660], 'Liotta': [1662], 'Identification,': [1664], 'purification,': [1665], 'partial': [1667], 'sequence': [1668, 1756], 'analysis': [1669], 'novel': [1673, 4051], 'motility-stimulating': [1674], 'protein.J.': [1675], '1992;': [1678, 3254], '267:': [1679], '2524-2529Abstract': [1680], 'synthesized': [1688], 'prepro-enzyme': [1691], 'and,': [1692, 3838], 'N-glycosylation': [1694], 'proteolytic': [1696], 'maturation,': [1697], 'lysoPLD': [1702, 4102], 'along': [1703], 'classical': [1705, 2104], 'secretory': [1706], 'route': [1707, 2851], '(27Jansen': [1708], 'Creemers': [1712], 'Waelkens': [1714], 'Van': [1716], 'Eynde': [1717], 'Proteolytic': [1723], 'maturation': [1724], '(NPP2),': [1729], 'metastasis-enhancing': [1732], '118:': [1738], '3081-3089Crossref': [1739], '(113)': [1742, 2365], '28Koike': [1745], 'Keino-Masu': [1747], 'Ohto': [1749], 'Masu': [1751], 'N-terminal': [1754, 3680], 'hydrophobic': [1755], '(ENPP2)': [1759], 'functions': [1760, 3723, 3867, 4073], 'signal': [1763], 'peptide.Genes': [1764], 'Cells.': [1765], '2006;': [1766, 2589], '11:': [1767], '133-142Crossref': [1768], '(59)': [1771, 3451], 'locally': [1776], 'rather': [1777], 'than': [1778, 3835], 'systemically,': [1779], 'although': [1780], 'present': [1784], 'circulation': [1787, 3394, 3436], 'where': [1788, 2504], 'accounts': [1790, 2369], 'maintaining': [1792], 'levels.': [1795], 'Circulating': [1796], 'short': [1801], 'half-life,': [1802], 'however,': [1803], 'rapidly': [1807, 3212, 3390], 'cleared': [1808, 3391], 'liver': [1811, 1837, 2670, 3402, 3483], '(29Jansen': [1812, 3458], 'Andries': [1814, 3460], 'Vekemans': [1816, 3462], 'Vanbilloen': [1818, 3464], 'Verbruggen': [1820, 3466], 'Rapid': [1824, 3470], 'clearance': [1825, 3471], 'circulating': [1828, 3474], 'factor': [1830, 3476, 3625], 'scavenger': [1834, 3480], 'sinusoidal': [1838, 3403, 3484], 'cells.Cancer': [1840, 3486], 'Lett.': [1841, 3376, 3487, 3554], '284:': [1843, 2356, 3489], '216-221Crossref': [1844, 3490], '(79)': [1847, 3493], 'Likely': [1850], 'sources': [1851], 'are': [1855, 2046, 2162, 2247, 3538, 3674, 3843, 3855], 'lymphatic': [1857], 'adipose': [1862], 'tissue,': [1863], 'which': [1864, 2045, 2116, 2224, 2533, 3892], 'express': [1865], 'secrete': [1867], '(10Kanda': [1872], '30Dusaulcy': [1909], 'Rancoule': [1911], 'Gres': [1913], 'Wanecq': [1915], 'Colom': [1917], 'Guigne': [1919], 'Valet': [1926, 3964], 'Saulnier-Blache': [1928, 3966], 'J.S.': [1929, 3584, 3967], 'Adipose-specific': [1930], 'disruption': [1931], 'enhances': [1934], 'nutritional': [1935], 'fattening': [1936], 'reduces': [1938], 'acid.J.': [1941, 3592], '1247-1255Abstract': [1946], '(142)': [1954], 'Despite': [1957, 3708], 'much': [1958, 2248], 'progress': [1959, 2183], 'made': [1960], 'signaling,': [1965], 'inner': [1967], 'workings': [1968], 'long': [1972, 4077], 'remained': [1973, 4078], 'elusive.': [1974], 'Recent': [1975], 'structural': [1976, 3710], 'changed': [1979], 'situation': [1981], 'provide': [1983], 'new': [1984], 'insights': [1985], 'functioning,': [1988], 'lysoPLD.': [1995], 'this': [1997, 2990], 'review,': [1998], 'relationships,': [2007], 'targets': [2018], 'small-molecule': [2027], 'their': [2032, 2220, 2375, 3709], 'modes.': [2034], 'six': [2038, 2252], 'GPCRs': [2040, 2119, 2173], '(termed': [2041], 'LPA1–6': [2042], 'LPAR1–6),': [2044], 'differentially': [2047, 3540], 'expressed': [2048], 'show': [2050, 2942], 'both': [2051, 3174], 'overlapping': [2052], 'properties': [2056], '(12Choi': [2057], 'be': [2098, 2256, 2384, 2478, 3038, 3502, 3871, 3875, 4098], 'divided': [2099], 'two': [2101, 3679], 'subfamilies.': [2102], 'LPA1–3': [2105], 'belong': [2107], 'so-called': [2110], '"endothelial': [2111], 'differentiation': [2112], 'gene"': [2113], '(Edg)': [2114], 'family,': [2115], 'includes': [2117], 'five': [2118], 'sphingosine': [2124], '1-phosphate': [2125], '(S1P)': [2126], '(31Chun': [2127], 'Hla': [2129], 'Lynch': [2131, 3146], 'K.R.': [2132, 3147], 'Spiegel': [2133], 'International': [2137], 'Union': [2138], 'Basic': [2140], 'Clinical': [2142], 'Pharmacology.': [2143], 'LXXVIII.': [2144], 'Lysophospholipid': [2145], 'Receptor': [2146], 'Nomenclature.Pharmacol.': [2147], '62:': [2150], '579-587Crossref': [2151], '(266)': [2154], 'Three': [2157], 'additional': [2158, 3865], '(LPA4–6)': [2161], 'more': [2163], 'closely': [2164], 'purinergic': [2168], '(P2Y)': [2170], '(32Yanagida': [2174], 'Kurikawa': [2176], 'Shimizu': [2178], 'Ishii': [2180], 'Current': [2182], 'non-Edg': [2185], 'research.Biochim.': [2189], '33-41Crossref': [2194], 'major': [2203], 'precursor': [2204], 'LPC': [2205, 2487, 2489, 2626, 2721, 2749, 3830], 'comprises': [2206], 'species': [2209, 2243, 2287, 2475], 'vary': [2211], 'length': [2214], 'degree': [2216], 'saturation': [2218], 'fatty': [2221, 2671], 'chain,': [2223], 'esterified': [2226], 'sn-1': [2229], '(or,': [2230], 'less': [2231, 2249, 2849], 'common,': [2232], 'sn-2)': [2233], 'position': [2234], 'backbone.': [2238], 'Ether-linked': [2239], '1-alkyl-LPA': [2240, 2286], '1-alkenyl-LPA': [2242], 'exist,': [2245], 'abundant.': [2250], 'All': [2251, 2473], 'stimulated': [2257], '1-acyl-LPA,': [2259], 'albeit': [2260], 'different': [2262, 3717], 'potencies.': [2263], 'Of': [2264], 'note,': [2265], 'some': [2266, 3832], '(LPA3': [2269], 'LPA6)': [2271], 'prefer': [2272], 'unsaturated': [2273, 2608, 2931], '2-acyl-LPA': [2274, 2932], 'ligand,': [2277], 'while': [2278, 2646], 'exhibits': [2280], 'strong': [2282], 'preference': [2283], 'ether-linked': [2285], '33Williams': [2321], 'J.R.': [2322], 'Khandoga': [2323], 'Goyal': [2325], 'Fells': [2327], 'J.I.': [2328], 'Perygin': [2329], 'D.H.': [2330], 'Siess': [2331], 'Parrill': [2333], 'Unique': [2339], 'selectivity': [2341], 'GPR92/LPA5': [2344], 'lysophosphatidate': [2345], 'indicates': [2347], 'role': [2348, 2581, 3545], 'activation.J.': [2352], '17304-17319Abstract': [2357], 'Detailed': [2368], 'pathways,': [2374], 'impact': [2376], 'gene': [2378, 3980], 'expression,': [2379], 'outcomes': [2382], 'elsewhere': [2386], '34Stortelers': [2448], 'Kerkhoven': [2450], 'Multiple': [2454], 'actions': [2455], 'fibroblasts': [2459], 'transcriptional': [2462], 'profiling.BMC': [2463], 'Genomics.': [2464], '387Crossref': [2467], '(50)': [2470, 2594], 'examined': [2476], 'produced': [2479, 3039, 3209], 'ATX-mediated': [2481], 'release': [2483], 'corresponding': [2486], 'substrate.': [2488], 'far': [2492], 'most': [2494, 2732, 3398, 4083], 'abundant': [2495], 'lysophospholipid': [2496, 2576, 3659], 'serum': [2500, 2707], '(concentration': [2501], '100–200': [2502], 'μM),': [2503], 'bound': [2507], 'mainly': [2508], 'albumin,': [2510, 3513], 'lipoproteins': [2514], 'α-1-acid': [2516], 'glycoprotein': [2517, 2573], '(35Tokumura': [2518], 'Nishioka': [2520], 'Yoshimoto': [2522], 'Shinomiya': [2524], 'Substrate': [2528], 'specificity': [2529], 'acids': [2537], 'rat': [2539, 2669], 'plasma.Biochim.': [2540], '1999;': [2543], '1437:': [2544], '235-245Crossref': [2545], '(32)': [2548], '36Ojala': [2551], 'P.J.': [2552], 'Hermansson': [2553], 'Tolvanen': [2555], 'Polvinen': [2557], 'Hirvonen': [2559], 'Impola': [2561], 'U.': [2562], 'Jauhiainen': [2563], 'Somerharju': [2565], 'Parkkinen': [2567], 'alpha-1': [2571], 'protein:': [2578], 'complementary': [2580], 'albumin': [2583, 2650], 'scavenging': [2586], 'lysophosphatidylcholine.Biochemistry.': [2588], '45:': [2590], '14021-14031Crossref': [2591], '37Croset': [2597], 'Brossard': [2599], 'Polette': [2601], 'Lagarde': [2603], 'Characterization': [2605], 'lysophosphatidylcholines': [2609], 'rat.Biochem.': [2613], '345:': [2616], '61-67Crossref': [2617], '(0)': [2620], 'Lysophospholipids': [2623], 'exist': [2630], 'free': [2632, 2719, 2748, 3658], 'monomers': [2633], 'aqueous': [2635], 'solutions,': [2636], 'critical': [2638], 'micelle': [2639], 'concentrations': [2640], 'low': [2643, 2653], 'micromolar': [2644], 'range,': [2645], 'they': [2647], 'bind': [2648], 'relatively': [2652], 'affinity': [2654, 3826], '[Kd': [2655], '∼2–5': [2656], 'μM': [2657], '(38Thumser': [2658], 'Voysey': [2660], 'J.E.': [2661], 'Wilton': [2662], 'D.C.': [2663], 'acid-binding': [2672], 'protein': [2673], 'albumin.Biochem.': [2675, 2708], '1994;': [2677], '301:': [2678], '801-806Crossref': [2679], '(117)': [2682], '39Guo': [2685], 'Shi': [2687], 'Meehan': [2693], 'Bian': [2695], 'Huang': [2697], 'basis': [2700], 'transport': [2702], '423:': [2711], '23-30Crossref': [2712], '(42)': [2715], 'Scholar)].': [2717], 'Therefore,': [2718], 'monomeric': [2720], 'exists': [2722], 'dynamic': [2724], 'equilibrium': [2725], 'large': [2728], 'carrier-bound': [2729], 'pool(s)': [2730], 'likely': [2733, 3399], 'serves': [2734], 'substrate': [2738], 'Consistent': [2741], 'this,': [2743], 'few': [2745], 'micromoles': [2746], 'sufficient': [2751], 'mediate': [2755], '(5Umezu-Goto': [2759], '13Jongsma': [2806], 'While': [2839], 'primary': [2843], 'LPA-producing': [2844, 2909, 2964], 'phospholipase,': [2845], 'second': [2847], 'common': [2850], 'involves': [2855], 'hydrolysis': [2857], 'phosphatidic': [2859], '(PA)': [2861], 'outer': [2864], 'leaflet': [2865], 'membrane': [2869], 'membrane-associated': [2871, 3215], '(PA-PLA1)': [2874], '40Inoue': [2897], 'Arima': [2899, 2954], 'Ishiguro': [2901, 2956], 'Arai': [2905, 2960, 3365, 3532], 'enzyme': [2910, 2965], 'PA-PLAalpha': [2911, 2966], 'regulates': [2912, 2948, 2967], 'hair': [2913, 2949, 2968, 3010], 'follicle': [2914, 2950, 2969, 3011], 'modulating': [2917, 2972], 'EGFR': [2918, 2973], 'signalling.EMBO': [2919, 2974], '4248-4260Crossref': [2923, 2978], '(101)': [2926, 2981], 'resulting': [2930], 'preferentially': [2934, 3762], 'LPA6': [2937], 'receptor.': [2938], 'Studies': [2939], 'mice': [2941], 'PA-PLA1-LPA6': [2945], '(40Inoue': [2952], 'dispensable': [2988, 3008], 'process': [2991], '(41Grisanti': [2992], 'Rezza': [2994], 'Clavel': [2996], 'Sennett': [2998], 'Rendl': [3000], 'Enpp2/Autotaxin': [3002], 'dermal': [3004], 'papilla': [3005], 'precursors': [3006], 'morphogenesis.J.': [3012], 'Invest.': [3013], 'Dermatol.': [3014], '133:': [3016], '2332-2339Abstract': [3017], '(14)': [3025], 'It': [3028, 3186], 'further': [3030, 3884], 'note': [3032], 'exogenous': [3041, 3202], 'PLDs,': [3042], 'those': [3044], 'Streptomyces': [3046], 'chromofuscus': [3047], '(42van': [3048], 'Dijk': [3049], 'M.C.': [3050], 'Postma': [3051], 'Hilkmann': [3053], 'Blitterswijk': [3058, 3239], 'W.J.': [3059, 3240], 'Exogenous': [3062], 'generates': [3065, 3157], 'activates': [3069, 3515], 'Ras,': [3070], 'Rho': [3071], 'Ca2+': [3073], 'pathways.Curr.': [3075], '1998;': [3077], '386-392Abstract': [3079], 'toxic': [3090], 'PLDs': [3091, 3172], 'spider': [3093, 3150], '(Loxosceles)': [3094], 'certain': [3096], 'pathogenic': [3097], 'corynebacteria': [3098], '(43van': [3099], 'Frederiks': [3102], 'Giepmans': [3104], 'B.N.': [3105], 'Pedrosa': [3106], 'Billington': [3108], 'Jost': [3110], 'B.H.': [3111], 'Tambourgi': [3112], 'D.V.': [3113], 'Spider': [3116], 'bacterial': [3118], 'sphingomyelinases': [3119], 'hydrolyzing': [3127, 3820], 'lysophosphatidylcholine.J.': [3128], '279:': [3132], '10833-10836Abstract': [3133], '(109)': [3141, 3605], '44Lee': [3144], 'Brown': [3148], 'recluse': [3149], '(Loxosceles': [3151], 'reclusa)': [3152], 'venom': [3153], '(PLD)': [3156], '(LPA).Biochem.': [3160], '391:': [3163], '317-323Crossref': [3164], '(104)': [3167], 'latter': [3171], 'sphingomyelin': [3175], 'produce': [3180], 'ceramide-1-phosphate': [3181], 'respectively.': [3185], 'currently': [3188], 'unclear': [3189], 'extent': [3192], 'excessive': [3193], 'toxicity': [3199], 'these': [3201], 'PLDs.': [3203], 'context,': [3207], 'newly': [3208], 'degraded': [3213, 3349], 'phosphatases': [3218, 3270, 3321], 'dephosphorylate': [3220], 'biologically': [3223, 3245], 'inactive': [3224, 3705], 'mono-acylglycerol': [3225], '(45van': [3226], 'der': [3227], 'Bend': [3228], 'R.L.': [3229], 'de': [3230], 'Widt': [3231], 'Corven': [3234], 'Metabolic': [3241], 'conversion': [3242], 'phospholipid,': [3247], 'fibroblasts.Biochim.': [3251], '1125:': [3255], '110-112Crossref': [3256], '(36)': [3259], '46Sciorra': [3262], 'V.A.': [3263], 'Roles': [3266], 'regulation': [3272], 'signaling.Biochim.': [3275], '1582:': [3279], '45-51Crossref': [3280], '(145)': [3283], '47Ren': [3286], 'Panchatcharam': [3288, 3408], 'Escalante-Alcalde': [3292], 'Smyth': [3296, 3420], '(LPP3)': [3301], '126-132Crossref': [3309], '(37)': [3312], '48Brindley': [3315], 'D.N.': [3316], 'Pilquil': [3317], 'signaling.J.': [3323], 'S225-S230Abstract': [3328], '(161)': [3336], 'cell-free': [3340], 'seminal': [3341, 3374], 'plasma,': [3342], 'hand,': [3346], 'soluble': [3351], 'prostatic': [3352], '(49Tanaka': [3355], 'Takanezawa': [3359], 'Kakehi': [3361, 3528], 'Prostatic': [3367], 'degrades': [3370], 'plasma.FEBS': [3375], '571:': [3378], '197-204Crossref': [3379], '(98)': [3382], 'When': [3385], 'injected': [3386], 'intravenously,': [3387], 'hepatic': [3396], 'uptake,': [3397], 'cells': [3405, 4093], '(50Salous': [3406], 'A.K.': [3407], 'Sunkara': [3410], 'Dong': [3414], 'Wang': [3416], 'Graf': [3418], 'G.A.': [3419], 'Mechanism': [3424], 'rapid': [3426], 'elimination': [3427], 'lipids': [3433], 'mice.J.': [3438], '54:': [3442], '2775-2784Abstract': [3443], 'radio-labeled': [3456], 'bioavailability': [3497, 3572], 'may': [3500, 3568, 3761], 'LPA-binding': [3505, 3547, 3664], 'proteins.': [3506, 3665], 'For': [3507], 'example,': [3508], 'presence': [3511, 3916], 'LPA2': [3518], 'receptors,': [3519], 'not': [3521], 'LPA3': [3522], '(51Hama': [3524], 'Bandoh': [3526], '(LPA)': [3536], 'activated': [3539], 'fluids:': [3543], 'possible': [3544], 'proteins': [3548, 3676], 'receptors.FEBS': [3553], '523:': [3556], '187-192Crossref': [3557], '(68)': [3560], 'High-affinity': [3563], 'gelsolin': [3567], 'influence': [3570], "LPA's": [3571], '(52Goetzl': [3573], 'Azuma': [3577], 'Stossel': [3579, 3614], 'T.P.': [3580, 3615], 'Turck': [3581], 'Karliner': [3583], 'Gelsolin': [3585], 'presentation': [3589], '275:': [3596], '14573-14578Abstract': [3597], '53Osborn': [3608], 'T.M.': [3609], 'Dahlgren': [3610], 'Hartwig': [3612], 'J.H.': [3613], 'Modifications': [3616], 'platelet-activating': [3624], 'gelsolin.Am.': [3628], 'Physiol.': [3630, 3632], '292:': [3634], 'C1323-C1330Crossref': [3635], '(88)': [3638], 'summary': [3642], 'then,': [3643], 'local': [3645], 'level': [3646], 'receptor-active': [3648], 'determined': [3651], 'complex': [3654], 'interplay': [3655], 'between': [3656], 'phosphatases,': [3662], 'closest': [3669], 'relatives,': [3670], 'ENPP1': [3671, 3727], 'ENPP3,': [3673], 'multi-domain': [3675], 'consisting': [3677], 'Cys-rich': [3681], 'somatomedin': [3682], 'B-like': [3683], '(SMB)': [3684], 'domains,': [3685], 'central': [3687], 'phosphodiesterase': [3689], '(PDE)': [3690], '(approximately': [3692], '400': [3693], 'amino': [3694], 'acids),': [3695], 'C-terminal': [3698], 'nuclease-like': [3699], '(NUC)': [3700], 'catalytically': [3704], '(Fig.': [3706, 3898, 4069], '1).': [3707, 3899, 4070], 'similarities,': [3711], 'three': [3713, 3901], 'ENPPs': [3714], 'very': [3716, 3845], 'activities.': [3721], 'membrane-bound': [3730], 'nucleotide': [3731, 3764, 3841], 'pyrophosphatase': [3732], '(2Stefan': [3733], 'ENPP3': [3760], 'sugars': [3765], '(54Korekane': [3766], 'J.Y.': [3769], 'Matsumoto': [3770], 'Nakajima': [3772], 'Takamatsu': [3774], 'Ohtsubo': [3776], 'Miyamoto': [3778], 'Hanashima': [3780], 'Kanekiyo': [3782], 'Kitazume': [3784], 'al.Identification': [3787], 'ectonucleotide': [3789], '3': [3791], '(ENPP3)': [3792], 'regulator': [3795], 'N-acetylglucosaminyltransferase': [3797], 'GnT-IX': [3798], '(GnT-Vb).J.': [3799], '288:': [3803], '27912-27926Abstract': [3804], '(25)': [3812], 'Although': [3815], 'capable': [3818], 'vitro,': [3823], 'apparent': [3825], '10-fold': [3833], 'higher': [3834], 'furthermore,': [3839], 'normally': [3844], 'low.': [3846], 'fact,': [3848], 'all': [3849], 'effects': [3852], 'attributable': [3856], 'subsequent': [3861], 'stimulation.': [3863], 'noncatalytic': [3866], 'cannot': [3870], 'excluded,': [3872], 'will': [3874], 'discussed': [3876], 'below.': [3877], 'intricacy': [3879], 'enhanced': [3885], 'alternative': [3887], 'splicing': [3888], 'mRNA,': [3891], 'gives': [3893], 'rise': [3894], 'splice': [3904], 'variants': [3905], 'termed': [3908, 4086], 'α,': [3909], 'β,': [3910], 'γ,': [3912], 'differ': [3913], 'absence': [3918], 'sequences': [3920], 'encoded': [3921], 'exons': [3923], '12': [3924], '21': [3926], '55Giganti': [3950], 'Rodriguez': [3952], 'Fould': [3954], 'B.': [3955], 'Moulharat': [3956], 'Coge': [3958], 'Chomarat': [3960], 'Galizzi': [3962], 'J.P.': [3963], 'Boutin': [3968], 'al.Murine': [3971], 'alpha,': [3975], 'beta,': [3976], 'gamma': [3978], 'isoforms:': [3979], 'organization,': [3981], 'distribution,': [3983], 'biochemical': [3985, 4047], 'characterization.J.': [3986], '283:': [3990], '7776-7789Abstract': [3991], '(96)': [3999], 'A': [4002], 'recently': [4003], 'identified': [4004], 'fourth': [4005], 'isoform': [4006], '(ATXδ)': [4007], 'nearly': [4009], 'identical': [4010, 4099], 'ATXβ,': [4012, 4087], 'lacks': [4015], 'four': [4016], 'residues': [4017], '"lasso': [4020], 'loop"': [4021], 'L2': [4023], 'linker': [4024], 'region': [4025], 'connects': [4027], 'PDE': [4029], 'NUC': [4031], '(56Hashimoto': [4033], 'Igarashi': [4037], 'Yatomi': [4041], 'characterization': [4048], 'isoform,': [4053, 4085], 'ATXδ,': [4054], 'four-amino': [4057], 'deletion.J.': [4059], '151:': [4062], '89-97Crossref': [4063], '(31)': [4066], 'isoform-specific': [4072], 'uncharacterized.': [4079], 'canonical': [4081], 'predominant': [4084], 'was': [4088], 'originally': [4089], 'cloned': [4090], 'teratocarcinoma': [4092], 'later': [4095], 'accounting': [4194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026909340', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 6}], 'updated_date': '2025-01-21T04:55:22.167628', 'created_date': '2016-06-24'}