Title: Histologic assessment of resected hepatocellular carcinoma after transcatheter hepatic arterial embolization
Abstract: CancerVolume 57, Issue 6 p. 1184-1191 ArticleFree Access Histologic assessment of resected hepatocellular carcinoma after transcatheter hepatic arterial embolization Hey-Chi Hsu DDS, MS (Path), Corresponding Author Hey-Chi Hsu DDS, MS (Path) Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaDepartment of Pathology, National Taiwan University Hospital, Taipei, Republic of China===Search for more papers by this authorTa-Cheng Wei MD, Ta-Cheng Wei MD Departments of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYuk-Ming Tsang MD, Yuk-Ming Tsang MD Departments of Radiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorMu-Zon Wu DDS, Mu-Zon Wu DDS Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYon-Ho Lin DDS, MS (Path), Yon-Ho Lin DDS, MS (Path) Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorSou-Ming Chuang MD, Sou-Ming Chuang MD Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this author Hey-Chi Hsu DDS, MS (Path), Corresponding Author Hey-Chi Hsu DDS, MS (Path) Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaDepartment of Pathology, National Taiwan University Hospital, Taipei, Republic of China===Search for more papers by this authorTa-Cheng Wei MD, Ta-Cheng Wei MD Departments of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYuk-Ming Tsang MD, Yuk-Ming Tsang MD Departments of Radiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorMu-Zon Wu DDS, Mu-Zon Wu DDS Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYon-Ho Lin DDS, MS (Path), Yon-Ho Lin DDS, MS (Path) Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorSou-Ming Chuang MD, Sou-Ming Chuang MD Departments of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of ChinaSearch for more papers by this author First published: 15 March 1986 https://doi.org/10.1002/1097-0142(19860315)57:6<1184::AID-CNCR2820570620>3.0.CO;2-9Citations: 59AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Ten cases of large hepatocellular carcinoma (HCC) (largest diameter, 6.5–15 cm) were surgically resected from 3 to 19 days after transcatheter hepatic arterial embolization (TAE) for histologic assessment of the effectiveness. Another two patients, including one with a small HCC (3.5 × 3 × 3 cm) who died of complications, were also studied. The patients' ages ranged from 20 to 64 years, 11 were men and 1 was a woman, and all positive for serum hepatitis B surface antigen. All 11 cases with large HCC were symptomatic before the HCC was clinically diagnosed. Alpha-fetoprotein levels were elevated in ten cases but immediately dropped to normal levels after TAE and resection in eight cases. An effective massive tumor coagulative necrosis of 99% already occurred 3 days after TAE. A necrosis involving more than 95% of the whole tumor mass was demonstrated in eight cases: one was a large HCC taken from an autopsy specimen, and TAE was done three times. This strongly indicates the effectiveness of TAE on the destruction of HCC. However, the presence of viable residual tumors in 11 cases also strongly argues for the necessity for surgical resection whenever it is possible. The failure of a complete necrosis was related to the extracapsular extension, liver invasion, satellite nodules, and portal vein involvement, and probably related to collateral and portal vein blood supply. References 1 Goldstein HM, Wallace S, Anderson JH et al. Transcatheter occlusion of abdominal tumors. Radiology 1976; 120: 539– 545. 2 Yamada R, Nakatsuka H, Nakamura K et al. Transcatheter embolization therapy in unresectable hepatomas: Experience in 15 cases. Acta Hepatol Jpn 1979; 20: 595– 603 (in Japanese). 3 Yamada R, Sato M, Kawabata M et al. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983; 148: 397– 401. 4 Sakurai M, Okamura J, Kuroda C. 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