Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2026809812', 'doi': 'https://doi.org/10.2165/00003088-198713060-00003', 'title': 'The Relationship Between Antidepressant Response and Tricyclic Antidepressant Plasma Concentrations', 'display_name': 'The Relationship Between Antidepressant Response and Tricyclic Antidepressant Plasma Concentrations', 'publication_year': 1987, 'publication_date': '1987-12-01', 'ids': {'openalex': 'https://openalex.org/W2026809812', 'doi': 'https://doi.org/10.2165/00003088-198713060-00003', 'mag': '2026809812', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3325215'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2165/00003088-198713060-00003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S69290020', 'display_name': 'Clinical Pharmacokinetics', 'issn_l': '0312-5963', 'issn': ['0312-5963', '1179-1926'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054186521', 'display_name': 'Paul J. Perry', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul J. Perry', 'raw_affiliation_strings': ['University of Iowa, .'], 'affiliations': [{'raw_affiliation_string': 'University of Iowa, .', 'institution_ids': ['https://openalex.org/I126307644']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056467103', 'display_name': 'Bruce Pfohl', 'orcid': 'https://orcid.org/0000-0001-7797-6536'}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bruce M. Pfohl', 'raw_affiliation_strings': ['University of Iowa, .'], 'affiliations': [{'raw_affiliation_string': 'University of Iowa, .', 'institution_ids': ['https://openalex.org/I126307644']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060738376', 'display_name': 'Sheldon G. Holstad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheldon G. Holstad', 'raw_affiliation_strings': ['University of Iowa, .'], 'affiliations': [{'raw_affiliation_string': 'University of Iowa, .', 'institution_ids': ['https://openalex.org/I126307644']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.64, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 77, 'citation_normalized_percentile': {'value': 0.79902, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '13', 'issue': '6', 'first_page': '381', 'last_page': '392'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11071', 'display_name': 'Molecular Mechanisms of Depression Treatment Strategies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11071', 'display_name': 'Molecular Mechanisms of Depression Treatment Strategies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10854', 'display_name': 'Epidemiology and Management of Bipolar Disorder', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nortriptyline', 'display_name': 'Nortriptyline', 'score': 0.9257533}, {'id': 'https://openalex.org/keywords/desipramine', 'display_name': 'Desipramine', 'score': 0.85804135}, {'id': 'https://openalex.org/keywords/tricyclic', 'display_name': 'Tricyclic', 'score': 0.8356942}, {'id': 'https://openalex.org/keywords/tricyclic-antidepressant', 'display_name': 'Tricyclic antidepressant', 'score': 0.8175901}, {'id': 'https://openalex.org/keywords/medication-effects', 'display_name': 'Medication Effects', 'score': 0.513723}, {'id': 'https://openalex.org/keywords/therapeutic-index', 'display_name': 'Therapeutic index', 'score': 0.5084447}, {'id': 'https://openalex.org/keywords/therapeutic-effect', 'display_name': 'Therapeutic effect', 'score': 0.42573604}], 'concepts': [{'id': 'https://openalex.org/C2780779033', 'wikidata': 'https://www.wikidata.org/wiki/Q61387', 'display_name': 'Nortriptyline', 'level': 3, 'score': 0.9257533}, {'id': 'https://openalex.org/C2779145073', 'wikidata': 'https://www.wikidata.org/wiki/Q58396', 'display_name': 'Imipramine', 'level': 3, 'score': 0.90229243}, {'id': 'https://openalex.org/C2780250439', 'wikidata': 'https://www.wikidata.org/wiki/Q423288', 'display_name': 'Desipramine', 'level': 4, 'score': 0.85804135}, {'id': 'https://openalex.org/C2781081902', 'wikidata': 'https://www.wikidata.org/wiki/Q3539074', 'display_name': 'Tricyclic', 'level': 2, 'score': 0.8356942}, {'id': 'https://openalex.org/C2779657639', 'wikidata': 'https://www.wikidata.org/wiki/Q908843', 'display_name': 'Tricyclic antidepressant', 'level': 4, 'score': 0.8175901}, {'id': 'https://openalex.org/C2779177272', 'wikidata': 'https://www.wikidata.org/wiki/Q76560', 'display_name': 'Antidepressant', 'level': 3, 'score': 0.7027058}, {'id': 'https://openalex.org/C2780216858', 'wikidata': 'https://www.wikidata.org/wiki/Q58397', 'display_name': 'Amitriptyline', 'level': 2, 'score': 0.65309167}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.61492276}, {'id': 'https://openalex.org/C3020079912', 'wikidata': 'https://www.wikidata.org/wiki/Q3918988', 'display_name': 'Plasma concentration', 'level': 2, 'score': 0.59516263}, {'id': 'https://openalex.org/C151956035', 'wikidata': 'https://www.wikidata.org/wiki/Q1132755', 'display_name': 'Logistic regression', 'level': 2, 'score': 0.52155685}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.51006466}, {'id': 'https://openalex.org/C19831878', 'wikidata': 'https://www.wikidata.org/wiki/Q659446', 'display_name': 'Therapeutic index', 'level': 3, 'score': 0.5084447}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46487358}, {'id': 'https://openalex.org/C102652120', 'wikidata': 'https://www.wikidata.org/wiki/Q2419430', 'display_name': 'Therapeutic effect', 'level': 2, 'score': 0.42573604}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29834086}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000929', 'descriptor_name': 'Antidepressive Agents, Tricyclic', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000929', 'descriptor_name': 'Antidepressive Agents, Tricyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012044', 'descriptor_name': 'Regression Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2165/00003088-198713060-00003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S69290020', 'display_name': 'Clinical Pharmacokinetics', 'issn_l': '0312-5963', 'issn': ['0312-5963', '1179-1926'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3325215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1585881766', 'https://openalex.org/W1966912214', 'https://openalex.org/W1975895811', 'https://openalex.org/W1978533945', 'https://openalex.org/W1982785064', 'https://openalex.org/W1983811410', 'https://openalex.org/W1988401639', 'https://openalex.org/W2010505978', 'https://openalex.org/W2014157672', 'https://openalex.org/W2018242123', 'https://openalex.org/W2025982460', 'https://openalex.org/W2026392346', 'https://openalex.org/W2028227271', 'https://openalex.org/W2049165791', 'https://openalex.org/W2050006242', 'https://openalex.org/W2055800227', 'https://openalex.org/W2056465704', 'https://openalex.org/W2071680582', 'https://openalex.org/W2091721706', 'https://openalex.org/W2113315561', 'https://openalex.org/W2114613490', 'https://openalex.org/W2131823335', 'https://openalex.org/W2150287316', 'https://openalex.org/W2411911521', 'https://openalex.org/W2427725690', 'https://openalex.org/W2887815066', 'https://openalex.org/W368475356', 'https://openalex.org/W4249108345'], 'related_works': ['https://openalex.org/W2474461487', 'https://openalex.org/W2412023912', 'https://openalex.org/W2398005610', 'https://openalex.org/W2340613121', 'https://openalex.org/W2126360678', 'https://openalex.org/W2074606171', 'https://openalex.org/W2071249246', 'https://openalex.org/W2068536124', 'https://openalex.org/W2045835123', 'https://openalex.org/W1986810757'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026809812', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T07:47:38.168522', 'created_date': '2016-06-24'}