Update on Mechanism and Catalytic Regulation in the NO Synthases

Name: Work Video:
Duration: 3 min 30 s
Dennis J. Stuehr; Jérôme Santolini; Zhiqiang Wang; Chin‐Chuan Wei; Subrata Adak
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1895, 1949, 2059, 2091, 2126, 2638, 2655, 2751, 2875, 3290, 3419, 3648, 3715, 3854, 3982, 4113], '2Guo': [61], 'F.Q.': [62], 'Okamoto': [63], 'M.': [64, 351, 484, 830, 895, 897, 1015, 4049], 'Crawford': [65], 'N.M.': [66], 'Science.': [67], '302:': [69], '100-103Crossref': [70], '(721)': [73], 'Scholar),': [75, 110, 240, 275, 298, 802, 1500, 2683, 3668], 'their': [76, 126, 2198, 2217, 2856, 3155, 3186, 3803], 'gene': [77], 'regulation': [78, 241], 'is': [79, 341, 424, 496, 651, 672, 683, 809, 827, 979, 1109, 1232, 1245, 1255, 1286, 1323, 1403, 1438, 1691, 1724, 2214, 2224, 2241, 2298, 2316, 2431, 2452, 2517, 2592, 3057, 3235, 3314, 3383, 3524, 3599, 3671, 4073], 'complex': [80, 983, 1136, 1153, 1266, 2321, 4225], '(3Newton': [81], 'D.C.': [82], 'Bevan': [83], 'S.C.': [84, 3777], 'Choi': [85], 'S.': [86, 174, 289, 570, 834, 953, 957, 1354, 1458, 1740, 1875, 1897, 1929, 1951, 1955, 1995, 2103, 2887, 2928, 2932, 3000, 3004, 3112, 3292, 3783, 3845, 4093], 'Robb': [87], 'G.B.': [88], 'Millar': [89], 'A.': [90, 290, 891, 1610, 1853, 2093, 2095, 2104, 2620, 2888, 3697, 3784, 3846], 'Wang': [91, 449, 526, 623, 697, 762, 990, 1763, 1898, 1956, 2658, 2933, 3005, 3113, 3293], 'Y.': [92, 2041, 2067], 'Marsden': [93], 'P.A.': [94], 'J.': [95, 182, 194, 196, 372, 457, 509, 534, 568, 575, 592, 597, 724, 770, 843, 998, 1028, 1060, 1165, 1170, 1202, 1352, 1359, 1376, 1381, 1456, 1463, 1480, 1485, 1584, 1589, 1613, 1738, 1745, 1764, 1773, 1789, 1794, 1827, 1832, 1856, 1873, 1880, 1902, 1927, 1934, 1953, 1962, 1983, 1996, 2015, 2044, 2076, 2262, 2267, 2623, 2659, 2668, 2731, 2736, 2930, 2939, 3002, 3011, 3117, 3297, 3404, 3659, 3700, 4056, 4098, 4120, 4145, 4150], 'Biol.': [96, 458, 535, 576, 598, 725, 771, 844, 999, 1029, 1061, 1171, 1203, 1360, 1382, 1464, 1486, 1590, 1614, 1746, 1774, 1795, 1833, 1857, 1881, 1903, 1935, 1963, 2016, 2045, 2077, 2268, 2624, 2669, 2737, 2940, 3012, 3118, 3298, 3405, 3701, 4057, 4099, 4121, 4151], 'Chem.': [97, 266, 459, 511, 536, 577, 599, 726, 772, 845, 865, 1000, 1030, 1062, 1172, 1204, 1361, 1383, 1465, 1487, 1591, 1615, 1747, 1775, 1796, 1834, 1858, 1882, 1904, 1936, 1964, 1998, 2017, 2046, 2078, 2131, 2269, 2625, 2670, 2738, 2866, 2941, 3013, 3119, 3299, 3406, 3426, 3702, 4058, 4100, 4122, 4152], '278:': [99, 461, 538, 774, 847, 1002], '636-644Abstract': [100], 'Full': [101, 103, 210, 212, 463, 465, 540, 542, 581, 583, 603, 605, 730, 732, 776, 778, 849, 851, 1004, 1006, 1034, 1036, 1066, 1068, 1176, 1178, 1208, 1210, 1365, 1367, 1387, 1389, 1469, 1471, 1491, 1493, 1595, 1597, 1619, 1621, 1751, 1753, 1779, 1781, 1800, 1802, 1838, 1840, 1862, 1864, 1886, 1888, 1908, 1910, 1940, 1942, 1968, 1970, 2021, 2050, 2052, 2082, 2084, 2273, 2275, 2629, 2631, 2674, 2676, 2742, 2744, 2945, 2947, 3017, 3019, 3123, 3125, 3303, 3305, 3410, 3412, 3706, 3708, 4062, 4064, 4104, 4106, 4126, 4128, 4156, 4158], 'Text': [102, 104, 211, 213, 464, 466, 541, 543, 582, 584, 604, 606, 731, 733, 777, 779, 850, 852, 1005, 1007, 1035, 1037, 1067, 1069, 1177, 1179, 1209, 1211, 1366, 1368, 1388, 1390, 1470, 1472, 1492, 1494, 1596, 1598, 1620, 1622, 1752, 1754, 1780, 1782, 1801, 1803, 1839, 1841, 1863, 1865, 1887, 1889, 1909, 1911, 1941, 1943, 1969, 1971, 2022, 2051, 2053, 2083, 2085, 2274, 2276, 2630, 2632, 2675, 2677, 2743, 2745, 2946, 2948, 3018, 3020, 3124, 3126, 3304, 3306, 3411, 3413, 3707, 3709, 4063, 4065, 4105, 4107, 4127, 4129, 4157, 4159], 'PDF': [105, 214, 467, 544, 585, 607, 734, 780, 853, 1008, 1038, 1070, 1180, 1212, 1369, 1391, 1473, 1495, 1599, 1623, 1755, 1783, 1804, 1842, 1866, 1890, 1912, 1944, 1972, 2023, 2054, 2086, 2277, 2633, 2678, 2746, 2949, 3021, 3127, 3307, 3414, 3710, 4066, 4108, 4130, 4160], '(53)': [108, 1041], 'they': [111, 3820], 'the': [113, 138, 162, 320, 332, 396, 418, 425, 429, 442, 558, 646, 673, 678, 691, 757, 807, 972, 1098, 1104, 1122, 1133, 1140, 1150, 1155, 1241, 1263, 1269, 1290, 1297, 1306, 1406, 1442, 1453, 1505, 1511, 1535, 1572, 1657, 1689, 1726, 1923, 2146, 2157, 2168, 2172, 2244, 2249, 2258, 2293, 2306, 2311, 2324, 2352, 2363, 2382, 2399, 2408, 2426, 2435, 2484, 2500, 2507, 2511, 2521, 2543, 2546, 2552, 2564, 2574, 2580, 2595, 2612, 2718, 2773, 2787, 2824, 2827, 2832, 2839, 3030, 3045, 3065, 3083, 3162, 3170, 3174, 3191, 3219, 3247, 3261, 3318, 3322, 3329, 3333, 3363, 3368, 3377, 3390, 3470, 3487, 3506, 3533, 3542, 3550, 3559, 3572, 3579, 3594, 3605, 3674, 3680, 3685, 3763, 3888, 3915, 3932, 3935, 3942, 4010, 4018, 4022, 4074, 4078, 4087, 4137, 4209, 4212, 4218, 4222, 4229, 4247], 'only': [114, 880, 2820, 3812, 4084], 'flavoheme': [115, 3211], 'enzymes': [116, 346, 3099, 3212], 'that': [117, 330, 347, 805, 928, 1251, 1275, 1408, 1723, 2191, 2222, 2335, 2461, 2818, 2957, 3224, 3336, 3447, 3918, 3931, 4086, 4180], 'utilize': [118], 'tetrahydrobiopterin': [119], '(H4B)': [120], 'as': [121, 336, 1683, 1706, 2228, 2230, 2342, 3359, 3885, 4207], 'a': [122, 133, 326, 388, 436, 815, 923, 946, 980, 1248, 1272, 1312, 1328, 1414, 1428, 1669, 1684, 1693, 1707, 1920, 2143, 2153, 2343, 2349, 2357, 2465, 2525, 2713, 2848, 2907, 2962, 2972, 3072, 3079, 3138, 3147, 3228, 3360, 3440, 3465, 3481, 3749, 3822, 3876, 4253], 'redox': [123, 823], 'cofactor,': [124], 'electron': [127, 413, 562, 618, 670, 741, 755, 3320, 3370, 3467, 3937], 'transfer': [128, 563, 671, 742, 3468, 3938], 'reactions': [129, 446], 'regulated': [131], 'by': [132, 685, 690, 814, 1289, 1337, 2243, 2301, 2318, 2377, 2434, 2454, 2925, 3044, 3356, 3457, 3484, 3805, 3887], 'Ca2+-binding': [134], 'protein': [135, 687], '(calmodulin).': [136], 'In': [137, 1106, 2536], 'past': [139], '5': [140], 'years,': [141], 'crystal': [142], 'structures': [143], 'of': [144, 334, 343, 391, 428, 435, 557, 821, 941, 976, 1113, 1126, 1247, 1262, 1281, 1413, 1510, 1534, 1571, 1922, 2145, 2171, 2177, 2192, 2201, 2254, 2288, 2295, 2313, 2326, 2345, 2396, 2428, 2440, 2446, 2478, 2502, 2524, 2545, 2563, 2599, 2605, 2728, 2776, 2789, 2801, 2814, 2826, 2841, 3067, 3317, 3345, 3362, 3463, 3500, 3566, 3597, 3609, 3618, 3688, 3753, 3910, 3934, 4025, 4034, 4077, 4211, 4221, 4252], 'NOS': [145, 224, 340, 386, 407, 826, 884, 942, 977, 1099, 1127, 1258, 1283, 1317, 1329, 1520, 1529, 1552, 2163, 2209, 2256, 2336, 2448, 2485, 2526, 2572, 2585, 2614, 2796, 2815, 3245, 3268, 3352, 3378, 3444, 3453, 3526, 4088, 4188, 4240], 'heme': [146, 420, 924, 1101, 1243, 1339, 1735, 2486, 2509, 2512, 3084, 3323, 3391, 3445, 3682, 4175], '(oxygenase)': [147], 'domains': [148], 'bacterial': [150], 'NOS-like': [151], 'proteins': [152, 4176], 'have': [153, 1444, 2473, 3137, 3146, 3195, 3213, 3821, 3924], 'shown': [154], 'how': [155, 1114, 2379, 3756, 4239], 'Arg,': [156], 'heme,': [157], 'H4B': [159, 620, 650, 669, 744, 750, 813, 822, 3358, 3366, 3485], 'bind': [160], 'active': [163], 'site': [164], '(4Crane': [165], 'B.R.': [166, 862, 3423, 3962, 4053], 'Rosenfeld': [167], 'R.J.': [168], 'Arvai': [169, 625, 699], 'A.S.': [170, 626, 700], 'Ghosh': [171, 173], 'Tainer': [175], 'J.A.': [176], 'Stuehr': [177, 455, 532, 573, 595, 633, 707, 722, 768, 863, 996, 1168, 1357, 1379, 1461, 1483, 1587, 1611, 1635, 1743, 1771, 1792, 1816, 1830, 1854, 1878, 1900, 1932, 1960, 2265, 2621, 2645, 2666, 2734, 2758, 2937, 3009, 3115, 3295, 3402, 3424, 3698, 3722, 3772, 4054, 4096, 4148], 'D.J.': [178, 456, 533, 574, 596, 634, 708, 723, 769, 864, 997, 1169, 1358, 1380, 1462, 1484, 1588, 1612, 1636, 1744, 1772, 1793, 1817, 1831, 1855, 1879, 1901, 1933, 1961, 2266, 2622, 2646, 2667, 2735, 2759, 2938, 3010, 3116, 3296, 3403, 3425, 3699, 3723, 3773, 4055, 4149], 'Getzoff': [179, 631, 705], 'E.D.': [180, 632, 706], 'EMBO': [181], '1999;': [183, 486, 1031, 1063, 1205, 2119], '18:': [184], '6271-6281Crossref': [185], '(100)': [188], '5Bird': [191], 'L.E.': [192], 'Ren': [193], 'Zhang': [195], 'Foxwell': [197], 'N.': [198], 'Hawkins': [199], 'A.R.': [200, 787, 3958], 'Charles': [201], 'I.G.': [202], 'Stammers': [203], 'Structure': [205], '(Lond.).': [206], '2002;': [207, 233, 252, 268, 291, 309, 361, 378, 727, 905, 2133, 2868, 2889, 3407, 3847, 3862, 3975], '10:': [208], '1687-1696Abstract': [209], '(76)': [217], 'Scholar).': [219, 316, 385, 493, 612, 667, 739, 874, 912, 970, 1396, 1645, 2282, 2768, 2896, 2954, 3026, 3132, 3312, 3435, 3732, 3792, 3997, 4071, 4165], 'Reviews': [220], 'available': [222, 828, 1439, 1451], 'on': [223, 1427, 2449, 2799, 3182, 3443, 4217], 'biochemistry': [225], '(6Mansuy': [226], 'D.': [227, 1059, 1201, 4097], 'Boucher': [228], 'J.L.': [229, 1027], 'Drug': [230], 'Metab.': [231], 'Rev.': [232, 267, 866, 2132, 2867, 3427], '34:': [234], '593-606Crossref': [235], '(30)': [238], '(7Li': [242], 'H.': [243, 504, 1634, 1815, 2073, 2644, 2757, 3721], 'Wallerath': [244], 'T.': [245, 247, 307, 836, 2069, 3860], 'Munzel': [246], 'Forstermann': [248], 'U.': [249, 288, 1021, 2102, 2886, 3782, 3844], 'Nitric': [250], 'Oxide.': [251], '7:': [253], '149-164Crossref': [254], '(188)': [257], '8Roman': [260], 'L.J.': [261, 478, 1053, 1195, 1770, 2665, 2861], 'Martasek': [262, 892, 1050, 1192, 2862], 'P.': [263, 893, 955, 1051, 1193, 2863], 'Masters': [264, 479, 900, 1054, 1196, 2864], 'B.S.': [265, 480, 901, 1055, 1197, 2865], '102:': [269, 2134, 2869], '1179-1190Crossref': [270, 2870], '(177)': [273, 2873], 'protein-protein': [276], 'interactions': [277, 3555], '(9Nedvetsky': [278, 3834], 'P.I.': [279, 2877, 3835], 'Sessa': [280, 2878, 3836], 'W.C.': [281, 2879, 3837], 'Schmidt': [282, 2880, 3838], 'H.H.': [283, 2881, 3839], 'Proc.': [284, 2098, 2882, 3778, 3840], 'Natl.': [285, 2099, 2883, 3779, 3841], 'Acad.': [286, 2100, 2884, 3780, 3842], 'Sci.': [287, 2101, 2885, 3781, 3843], '99:': [292, 2890, 3848], '16510-16512Crossref': [293, 2891, 3849], '(66)': [296, 2894, 3852], 'post-translational': [300], 'modifications': [301], '(10Greif': [302], 'D.M.': [303, 374, 3856], 'Kou': [304, 3857], 'R.': [305, 454, 531, 630, 704, 767, 838, 889, 995, 3858], 'Michel': [306, 3859], 'Biochemistry.': [308, 377, 485, 635, 659, 709, 794, 904, 1637, 1818, 2647, 2760, 3282, 3724, 3861, 3989], '41:': [310, 379, 906, 3863], '15845-15853Crossref': [311, 3864], '(91)': [314, 3867], 'This': [317, 423, 2239, 2494, 2708, 2987, 3027, 3179, 3313, 3523, 3582, 3928], 'minireview': [318], 'updates': [319], 'NO': [321, 335, 349, 401, 987, 1080, 1095, 1161, 1230, 1238, 1253, 1322, 1398, 1407, 1558, 1654, 2202, 2296, 2314, 2340, 2353, 2405, 2482, 2492, 2505, 2515, 2540, 2581, 2601, 2607, 2695, 2705, 2715, 2729, 2771, 2784, 2791, 2922, 2974, 2991, 2996, 3051, 3101, 3156, 3197, 3256, 3539, 3611, 3677, 3797, 3911, 4035], 'biosynthetic': [322, 430, 679, 3612], 'mechanism': [323, 1315, 1419, 1575, 3047, 4001, 4220], 'describes': [325], 'global': [327, 1313, 1417, 1421, 1573, 1924, 2147, 2245, 2331, 2828, 3999], 'catalytic': [328, 2164, 2328, 2816, 4203], 'model': [329, 1423, 1437, 1504, 2247, 2333, 2830], 'highlights': [331], 'role': [333], 'an': [337, 412, 617, 754, 1111, 1129, 1720, 2285, 2455, 2600, 2782, 3255], 'intrinsic': [338, 3672], 'regulator.': [339], 'one': [342, 2196, 2211], 'few': [344], 'heme-containing': [345], 'make': [348], '(11Rudolf': [350], 'Einsle': [352], 'O.': [353], 'Neese': [354], 'F.': [355], 'Kroneck': [356], 'P.M.': [357], 'Biochem.': [358], 'Soc.': [359, 512, 1999], 'Trans.': [360], '30:': [362], '649-653Crossref': [363], '12Hendrich': [367], 'M.P.': [368], 'Upadhyay': [369], 'A.K.': [370], 'Riga': [371], 'Arciero': [373], 'Hooper': [375], 'A.B.': [376], '4603-4611Crossref': [380], '(34)': [383], 'hydroxylates': [387, 929], 'guanidino': [389], 'nitrogen': [390], 'Arg': [392, 443, 500, 930, 3340, 3921], 'then': [394, 2360], 'oxidizes': [395], 'Nω-hydroxy-l-arginine': [397], 'intermediate': [398], '(NOHA)': [399], 'l-citrulline': [403], '(Scheme': [404], '1).': [405, 422, 749, 938, 2304, 3351], 'The': [406, 668, 875, 939, 1146, 1435, 1560, 2330, 2371, 2421, 2443, 2476, 2603, 3133, 3496, 3562, 3614, 3998, 4166], 'flavoprotein': [408, 647, 1124, 1147, 3471, 4089], 'domain': [409, 648, 1125, 4139], 'first': [410, 973], 'provides': [411, 1128], '(derived': [414], 'from': [415, 619, 645, 743, 1240, 1441, 1568, 1580, 1919, 2142, 2216, 2499, 3389, 3469], 'NADPH)': [416], 'ferric': [419, 437, 981, 1100, 1134, 1142, 1151, 1226, 1242, 1264, 1708, 2319, 2383, 2508, 2522, 2547, 3681], '(Fig.': [421, 748, 937, 1076, 1144, 2303, 2369, 2419, 2556, 2706, 2794, 3060, 3087, 3177, 3258, 3350], 'slowest': [426, 675], 'step': [427, 676, 3490], 'reaction': [431, 759, 817, 2501], 'enables': [433, 2709, 2778, 3190], 'formation': [434, 2322, 2391, 3476], 'heme-superoxy': [438], 'species': [439, 877, 926, 943, 948, 1300, 2549, 2567, 3335, 3347, 3545, 3575, 3917, 3945], '(I)': [440], 'or': [444, 521, 644, 931, 945, 1699, 2597, 3091, 3341, 3922], 'NOHA': [445, 758, 936, 3342, 3923], '(13Wei': [447, 524, 760, 988], 'C-C.': [448, 525, 761, 989], 'Z.Q.': [450, 527, 624, 698, 719, 763, 991, 3399, 4045], 'Hemann': [451, 528, 627, 701, 764, 992], 'C.': [452, 529, 628, 702, 765, 789, 993], 'Hille': [453, 530, 629, 703, 766, 994], '46668-46673Abstract': [462, 539, 775, 1003], '(103)': [470, 547, 783, 1011], '14Ledbetter': [473], 'A.P.': [474], 'McMillan': [475], 'K.': [476, 1608, 1632, 1813, 1851, 2618, 2642, 2755, 3695, 3719, 4051], 'Roman': [477, 1052, 1194], 'Dawson': [481, 898, 3965], 'J.H.': [482, 899, 3966], 'Sono': [483, 896], '38:': [487], '8014-8021Crossref': [488], '(56)': [491], 'Species': [494, 613, 913], 'I': [495, 614, 3348], 'not': [497, 523, 985, 1326, 3589, 3925], 'reactive': [498, 551, 3943], 'toward': [499, 552], 'but': [501, 1325, 2347, 2392, 2993, 3145, 3588], 'may': [502, 522, 751, 915, 932, 3736, 3758, 4039, 4194], '(15Huang': [503], 'Hah': [505], 'J.M.': [506, 1768, 2663], 'Silverman': [507], 'R.B.': [508], 'Am.': [510, 1997], '2001;': [513, 578, 600, 963, 1173, 1362, 1384, 1466, 1488, 1592, 1638, 1748, 1797, 1819, 1835, 1883, 1937, 1965, 2105, 2270, 2648, 2739, 2761, 2942, 3014, 3725, 4101, 4153], '123:': [514], '2674-2676Crossref': [515], '(63)': [518], 'Scholar)': [520, 549, 643, 1075, 1217, 3869, 4135], 'be': [550, 1349, 1425, 2375, 2781, 2821, 3325, 3737, 3880, 3902, 3939, 3946, 4040, 4186, 4196, 4228, 4235], 'NOHA.': [553], 'Rates': [554], 'individual': [559, 1448], 'binding': [560, 2496, 2516, 2541, 3438, 3678], 'steps': [564], 'known': [566], '(16Santolini': [567, 1351, 1455], 'Adak': [569, 1353, 1457, 1739, 1874, 1928], 'Curran': [571, 1355, 1459, 1741, 1876, 1930], 'C.M.L.': [572, 1356, 1460, 1742, 1877, 1931], '276:': [579, 601, 1174, 1363, 1385, 1467, 1489, 1593, 1749, 1798, 1836, 1884, 1938, 1966, 2271, 2740, 2943, 3015, 4102, 4154], '1233-1243Abstract': [580, 1364, 1468, 1750, 1885, 1939], '(90)': [588, 1372, 1476, 1758, 1893, 1947], '17Santolini': [591, 1375, 1479], 'Meade': [593, 1166, 1377, 1481, 1585, 1790, 1828, 2263, 2732, 4146], 'A.L.': [594, 1025, 1167, 1378, 1482, 1586, 1791, 1829, 2264, 2733, 4147], '48887-48898Abstract': [602, 1175, 1386, 1490, 1594, 1799, 1837, 2272, 2741, 4155], '(118)': [610, 1183, 1394, 1498, 1602, 1807, 1845, 2280, 2749, 4163], 'can': [615, 1117, 1148, 1424, 2374, 2587, 2687, 3376, 3900], 'receive': [616], '(18Wei': [621, 695], 'C.C.': [622, 696, 860, 3421, 4047], '42:': [637, 711, 796], '1969-1977Crossref': [638, 712], '(54)': [641, 715, 1915, 3130], 'when': [649, 2520, 2590], 'absent': [652], '(19Rusche': [653, 3276], 'K.M.': [654, 3277], 'Spiering': [655, 3278], 'M.M.': [656, 3279], 'Marletta': [657, 792, 3280], 'M.A.': [658, 793, 3281, 3638], '1998;': [660, 3283, 4123], '37:': [661, 3284], '15503-15512Crossref': [662, 3285], '(169)': [665, 3288], 'second': [674, 3319, 3364, 3369, 3936], 'reaction.': [680, 3613], 'Its': [681], 'kinetics': [682], 'influenced': [684, 1288, 2433], 'surrounding': [686], 'residues': [688], 'pterin': [692], 'structure': [693], 'itself': [694], '20Wang': [718], 'Wei': [720, 3400, 4046], 'C.-C.': [721, 3401], '277:': [728, 3408], '12830-12837Abstract': [729, 3409], '(36)': [737, 3417], 'Timely': [740], 'prevents': [745], 'superoxide': [746, 3387], 'release': [747, 1116, 1405, 2315, 2341, 2354, 2406, 2430, 2582, 2727, 2923, 2997, 3052, 3102, 3198, 3388], 'also': [752, 1287, 1331, 2393, 2432, 3683, 4195], 'donate': [753], '21Hurshman': [786], 'Krebs': [788], 'Edmondson': [790], 'D.E.': [791, 3984], '13287-13303Crossref': [797], '(52)': [800], 'case': [806], 'radical': [808], 'reduced': [810], 'back': [811], 'downstream': [816], 'intermediate.': [818], 'Further': [819], 'discussion': [820], 'function': [824, 2344, 3871, 4189], '(22Sorlie': [829], 'Gorren': [831], 'A.C.': [832], 'Marchal': [833], 'Shimizu': [835], 'Lange': [837], 'Andersson': [839], 'K.K.': [840], 'Mayer': [841], 'B.': [842], '48602-48610Abstract': [848], '(55)': [856], '23Wei': [859, 3420], 'Crane': [861, 3422, 3961, 4052], '103:': [868, 3429], '2365-2383Crossref': [869, 3430], '(167)': [872, 3433], 'heme-peroxo': [876], '(II)': [878], 'has': [879, 949, 2463, 2608, 2961], 'been': [881, 950, 1445, 2609, 3926], 'observed': [882, 974], 'at': [885, 1292, 2206, 2225, 2323, 2348, 2489, 2691, 2701, 2786, 2898, 3486], 'cryogenic': [886], 'temperature': [887], '(24Davydov': [888], 'Ledbetter-Rogers': [890], 'Larukhin': [894], 'Hoffman': [902], 'B.M.': [903], '10375-10381Crossref': [907], '(108)': [910], 'II': [914], 'become': [916], 'protonated': [917], 'lose': [919], 'water': [920], 'form': [922, 2523], 'iron-oxo': [925], '(III)': [927], 'react': [933, 3338, 3919], 'directly': [934], 'with': [935, 1222, 1296, 2185, 2506, 3082, 3142, 3218, 3339, 3528, 3547, 3920, 4256], 'reactivity': [940], 'III': [944], 'related': [947, 3519], 'studied': [951], '(25Porasuphatana': [952], 'Tsai': [954, 1024], 'Pou': [956], 'Rosen': [958], 'G.M.': [959], 'Biochim.': [960, 2116], 'Biophys.': [961, 2117], 'Acta.': [962, 2118], '1526:': [964], '95-104Crossref': [965], '(12)': [968], 'Importantly,': [971], 'product': [975, 1115, 2385, 4215, 4241], 'catalysis': [978, 2530], 'heme-NO': [982, 1135, 1152, 1157, 1265, 1299, 2320, 2384, 2548, 2566, 3437, 3475, 3544, 3574, 4224], 'free': [986, 1440], '26Negrerie': [1014], 'Berka': [1016], 'V.': [1017], 'Vos': [1018], 'M.H.': [1019], 'Liebl': [1020], 'Lambry': [1022], 'Martin': [1026, 2036, 2064], '274:': [1032, 1064, 1206], '24694-24702Abstract': [1033], '27Scheele': [1044, 1186], 'J.S.': [1045, 1187, 2043, 2071, 2097], 'Bruner': [1046, 1188], 'E.': [1047, 1189], 'Kharitonov': [1048, 1190], 'V.G.': [1049, 1191], 'Sharma': [1056, 1198, 4048], 'V.S.': [1057, 1199], 'Magde': [1058, 1200], '13105-13110Abstract': [1065, 1207], '(51)': [1073, 1215], '1).Fig.': [1077], '1Model': [1078], 'biosynthesis.': [1081, 2975, 3912], 'See': [1082], 'text': [1083], 'details.View': [1085], 'Large': [1086], 'Image': [1087], 'Figure': [1088], 'ViewerDownload': [1089], '(PPT)': [1090], 'As': [1091], 'noted,': [1092], 'practically': [1093], 'all': [1094], 'binds': [1096, 3536], 'before': [1102, 3343], 'exiting': [1103], 'enzyme.': [1105, 1227, 3675], 'isolation,': [1107], 'this': [1108, 1549, 2537, 2807, 2899, 3153, 3354, 3381, 3455, 3872, 4042], 'just': [1110], 'example': [1112], 'limit': [1118], 'enzyme': [1119, 1270, 1561, 1721, 2251, 2364, 2553, 3167, 3183, 3330, 3535], 'catalysis.': [1120, 1318], 'However,': [1121, 2194, 2305, 2913, 3260], 'attached': [1123], 'alternative': [1130], 'path': [1131], 'return': [1138], 'initial': [1141], 'state': [1143, 2260, 3176], '2A).': [1145], 'reduce': [1149], 'ferrous': [1156, 1298, 2565, 3474, 3534, 3543, 3573, 4223], 'species,': [1158], 'which': [1159, 1293, 2207, 2403, 2577, 4243], 'releases': [1160, 1252], 'very': [1162], 'slowly': [1163], '(17Santolini': [1164, 1583, 2261, 2730, 4144], 'so': [1219, 2569, 3393, 3593, 3897], 'reacts': [1220, 1295, 3546], 'instead': [1221, 4033], 'O2': [1223, 1294, 3498, 3529, 3537, 3548, 3606], 'regenerate': [1225], 'Consequently': [1228], 'after': [1229], 'biosynthesis': [1231, 2203, 2297, 2792, 2992, 3157], 'finished': [1233], 'two': [1234, 1727, 2812, 3459, 3531], 'different': [1235, 2250, 3806], 'cycles': [1236, 1310, 1336], 'compete;': [1237], 'dissociation': [1239, 1399], '(kd)': [1244, 1400], 'part': [1246], '“productive': [1249], 'cycle”': [1250, 1274], 'essential': [1256], 'bioactivity.': [1259], 'Conversely,': [1260, 3039], 'reduction': [1261, 1340, 3446, 3483], '(kr′)': [1267], 'channels': [1268], 'into': [1271, 1648, 2398, 3246, 3254], '“futile': [1273], 'ultimately': [1276, 3251], 'generates': [1277], 'nitrate': [1278, 2417], 'place': [1280], 'NO.': [1282], 'futile': [1284, 1309, 2400, 2414, 2575, 3171, 3248, 3478, 3551, 4031, 4202, 4213], 'cycling': [1285, 2415, 4032], 'rate': [1291, 1449, 2294, 2312, 2427, 2924, 2998, 3933], '(kox': [1301], 'Fig.': [1303, 1564, 2458], '2).': [1304], 'Together,': [1305], 'productive': [1307, 2409, 4200], 'create': [1311, 1719], 'kinetic': [1314, 1418, 1422, 1537, 1574, 1925, 2148, 2246, 2332, 2829, 2834, 3441, 4000, 4012, 4023, 4080, 4250], 'Thus,': [1319, 2584, 3436], 'synthesize': [1321], 'good': [1324], 'sufficient;': [1327], 'must': [1330, 3324], 'control': [1332], 'partitioning': [1333], 'between': [1334, 1725, 2308, 2423], 'both': [1335], 'balancing': [1338], '(kr,': [1341, 1539], 'kr′)': [1342], '2kr': [1343], 'kr′': [1345, 1672], 'were': [1346, 1566, 2978, 3104], 'found': [1347], 'equivalent': [1350], 'if': [1401, 2195, 3571], 'it': [1402, 1409, 1679, 1702, 2213, 2397, 2591, 2722, 2779, 3253, 3265, 3670, 3757], 'makes.': [1410], 'Computer': [1411], 'simulations': [1412, 1570], 'more': [1415, 2395, 2571, 3244], 'detailed': [1416, 1436], '3The': [1420], 'run': [1426, 1446], 'desktop': [1429], 'computer': [1430, 1569], 'using': [1431, 1447, 3458, 3949], 'programs': [1432], 'like': [1433, 3828], 'Mathcad.': [1434], 'authors.': [1443], 'measurements': [1450], 'literature': [1454], 'these': [1502], 'accurately': [1503], 'pre-steady-state': [1506], 'steady-state': [1508, 1557, 1653, 2529], 'behaviors': [1509], 'mammalian': [1512, 2174], '(eNOS),': [1514], '(nNOS),': [1516], '(iNOS)': [1519], 'isozymes.': [1521], 'Some': [1522], 'fundamental': [1523], 'concepts': [1524], 'described': [1526], 'below.': [1527], 'Each': [1528], 'Distributes': [1530], 'Differently': [1531], 'during': [1532, 1556, 1652, 2528, 3173, 3538], 'Catalysis—Values': [1533], 'three': [1536, 2173, 2613, 2833, 4011, 4079], 'parameters': [1538, 4013, 4024, 4251], 'kox,': [1540, 2803, 3884], 'kd)': [1541], 'differ': [1542, 2588, 3504, 4014], 'significantly': [1543], 'among': [1544, 3505, 4015, 4174], 'NOSs': [1545, 1646, 1732, 2175, 2283, 3070, 3205, 3220, 3225, 3507, 4016, 4027, 4038], '(Table': [1546, 2220, 2968, 3150, 3221, 3521, 4177], 'I),': [1547, 3222], 'causes': [1550, 1678, 1701, 3165], 'each': [1551, 2208, 2255, 2327, 2441, 2447], 'distribute': [1554, 1647], 'differently': [1555], 'synthesis.': [1559], 'distributions': [1562, 1578], '2B': [1565], 'derived': [1567], 'mimic': [1577], 'estimated': [1579], 'actual': [1581, 2199], 'experiments': [1582], '28Abu-Soud': [1605, 1848], 'H.M.': [1606, 1630, 1762, 1811, 1849, 2616, 2640, 2657, 2753, 3693, 3717], 'Ichimori': [1607, 1631, 1812, 1850, 2617, 2641, 2754, 3694, 3718], 'Presta': [1609, 1852, 2619, 3696], '2000;': [1616, 1859, 1905, 2047, 2079, 2626, 3120, 3300, 3661, 3703], '275:': [1617, 1860, 1906, 2048, 2080, 2627, 3121, 3301, 3704], '17349-17357Abstract': [1618, 1861, 2628, 3705], '(115)': [1626, 1869, 2636, 3713], '29Abu-Soud': [1629, 1810, 2639, 2752, 3716], 'Nakazawa': [1633, 1814, 2643, 2756, 3720], '40:': [1639, 1820, 2649, 2762, 3726], '6876-6881Crossref': [1640, 1821, 2650, 2763, 3727], '(64)': [1643, 1824, 2653, 2766, 3730], 'five': [1649], 'main': [1650], 'synthesis,': [1655], 'namely': [1656], 'ferric,': [1658], 'ferrous,': [1659], 'ferrous-O2': [1660], '(or': [1661, 2901], 'ferric-superoxy),': [1662], 'ferric-NO,': [1663], 'ferrous-NO': [1665, 1685], 'forms.': [1666], 'For': [1667, 1687, 1710, 2166, 2689, 3808, 3874, 3913], 'fast': [1670, 1714, 1717, 2229, 2774, 3482], 'kr,': [1671, 2346, 2468, 2802], 'relative': [1673, 1696], 'kd': [1675, 1698, 2436, 4143, 4172], 'kox': [1677, 1700, 1718, 2438, 2775, 3149, 3164, 3567, 4141, 4170], 'exist': [1681, 1704, 3894], 'predominantly': [1682, 1705], 'species.': [1686, 1709], 'eNOS': [1688, 2470, 2533, 2844, 2911, 3043, 3598, 3689, 3740, 3816, 3826], 'situation': [1690, 3583], 'reversed;': [1692], 'slow': [1694, 2981, 3233, 3262, 3466], 'kr': [1695, 1715, 2218, 2302, 2309, 2380, 2388, 2424, 2964, 2983, 3034, 3041, 3056, 3140, 3188, 3215, 3234, 3239, 3263, 3811, 4091], 'its': [1712, 2339, 2390, 2450, 2790, 2921, 2990, 2995, 3050, 3054, 3449, 3492, 3610, 3883, 4003, 4199, 4257], 'moderately': [1713], 'distribution': [1722, 2158, 2252, 2554, 3184], 'extremes.Table': [1728], 'IKinetic': [1729], 'values': [1730, 2219, 2439, 3216, 3503, 4008, 4173], 'selected': [1734], 'proteinsProteinkrkdkoxApparent': [1736], 'KmO2Refs.s-1s-1s-1μmnNOS3-450.235016Santolini': [1737], '30Abu-Soud': [1761, 2656], 'Rousseau': [1765, 2660], 'D.L.': [1766, 2661], 'Fukuto': [1767, 2662], 'Ignarro': [1769, 2664], '1995;': [1776, 2671, 3785], '270:': [1777, 2672], '22997-23006Abstract': [1778, 2673], '(201)': [1786, 2681], 'ScholariNOS0.9-1.52313017Santolini': [1788], 'ScholareNOS0.130.6417Santolini': [1826], 'ScholarW409F': [1871], 'nNOS1.851.3NA16Santolini': [1872], '32Adak': [1896], 'Q.': [1899, 1957, 2934, 3006, 3114, 3294], '17434-17439Abstract': [1907, 3122], 'ScholarS1412D': [1917], 'nNOS5.45NA738aCalculated': [1918], 'simulation': [1921, 2144], 'model.16Santolini': [1926], '31Adak': [1950], 'Santolini': [1952, 2929, 3001], 'Tikunova': [1954, 2931, 3003], 'Johnson': [1958, 2935, 3007], 'J.D.': [1959, 2936, 3008], '1244-1252Abstract': [1967, 2944, 3016], '(105)': [1975, 2952, 3024], 'ScholarCyt': [1977], 'P450BM399': [1978], '(15': [1979], '°C)NANANA42Ost': [1980], 'T.W.': [1981, 3771], 'Clark': [1982], 'Mowat': [1984], 'C.G.': [1985], 'Miles': [1986], 'C.S.': [1987], 'Walkinshaw': [1988], 'M.D.': [1989], 'Reid': [1990], 'G.A.': [1991], 'Chapman': [1992], 'S.K.': [1993], 'Daff': [1994], '125:': [2001], '15010-15020Crossref': [2002], '(98)': [2005], 'ScholarMammalian': [2007], 'Cyt': [2008], 'P450NANANA4-10': [2009], '(10': [2010, 2031], '°C)43Jones': [2011], 'D.P.': [2012], 'Mason': [2013], 'H.S.': [2014], '1978;': [2018], '253:': [2019], '4874-4880Abstract': [2020], 'ScholarFlavohemoglobin150': [2026], '(37': [2027, 2113], '°C)200-4000': [2028], '(20': [2029, 2033], '°C)12': [2030], '°C)60-90': [2032], '°C)44Gardner': [2034], 'A.M.': [2035, 2063], 'L.A.': [2037, 2065], 'Gardner': [2038, 2062], 'P.R.': [2039, 2061, 4119], 'Dou': [2040, 2066], 'Olson': [2042, 2070], '12581-12589Abstract': [2049], '(140)': [2057], '45Gardner': [2060], 'Li': [2068], 'Zhu': [2072], 'Riggs': [2074], 'A.F.': [2075], '31581-31587Abstract': [2081], '(133)': [2089], '46Hausladen': [2092], 'Gow': [2094], 'Stamler': [2096], '98:': [2106], '10108-10112Crossref': [2107], '(141)': [2110], 'ScholarMyoglobinNA4010-3': [2112], '°C)NA47Cooper': [2114], 'C.E.': [2115], '1411:': [2120], '290-309Crossref': [2121], '(463)': [2124], '48Moller': [2127], 'J.K.': [2128], 'Skibsted': [2129], 'L.H.': [2130], '1167-1178Crossref': [2135], '(193)': [2138], 'Scholara': [2140], 'Calculated': [2141], 'model.': [2149], 'Open': [2150], 'table': [2151], 'new': [2154], 'tab': [2155], 'Knowing': [2156], 'pattern': [2159, 2253, 2555], 'helps': [2160], 'understand': [2162], 'behavior.': [2165], 'example,': [2167, 2690, 3809, 3914], 'specific': [2169], 'activities': [2170, 3804], 'rank': [2178], 'order': [2179], 'iNOS': [2180, 2231, 2472, 2697, 2710, 2777, 3691, 3754, 3818], '≥': [2181], 'nNOS': [2182, 2186, 2223, 2462, 2846, 2918, 2959, 3096, 3110, 3587, 3619, 3622, 3875, 3890], '>': [2183], 'activity': [2187, 2586, 2793, 2797, 3623], 'being': [2188], '4': [2189], 'times': [2190, 2235, 3106, 3373], 'eNOS.': [2193, 2238], 'considers': [2197], 'rates': [2200, 3103, 3199], '(the': [2204], 'speed': [2205], 'makes': [2210, 3154, 3264, 3813], 'NO)': [2212], 'clear': [2215], 'I)': [2221, 2969, 4178], 'least': [2226], 'twice': [2227], 'about': [2233, 2692, 3371], '30': [2234], 'faster': [2236, 2366, 2368, 2963, 2973, 3148, 3214, 3374], 'than': [2237, 2965, 3108, 3159, 3200, 3375, 3515], 'discrepancy': [2240], 'explained': [2242], 'steady': [2259, 2714, 3175, 3580], 'Have': [2284, 3206], 'Optimal': [2286], 'Rate': [2287], 'Heme': [2289, 3208], 'Reduction—With': [2290], 'sufficient': [2291, 3384], 'substrates': [2292], 'simply': [2299], 'limited': [2300], 'relationship': [2307, 2422], 'modified': [2317], 'end': [2325], 'event.': [2329], 'predicts': [2334], 'will': [2337, 2355, 3242, 3337, 3929, 4234], 'increase': [2338, 2909, 3049, 3742, 3802, 3882], 'certain': [2350], 'point': [2351, 2902, 2915], 'reach': [2356], 'maximum': [2358], 'fall': [2361], 'despite': [2362], 'working': [2365], '3).': [2370, 2420, 3061, 3259], 'bell-shaped': [2372], 'curves': [2373], 'rationalized': [2376], 'considering': [2378], 'impacts': [2381, 3448], 'complex.': [2386], 'Increasing': [2387], 'speeds': [2389], 'partitions': [2394], 'cycle': [2401, 3172, 3249, 3552, 4214], '(kr′),': [2402], 'diminishes': [2404], 'via': [2407], 'pathway': [2410], 'reciprocally': [2412], 'increases': [2413, 2542, 3684], 'production': [2418, 2562], 'products': [2429], 'NOS.': [2442], 'approximate': [2444], 'location': [2445], 'curve': [2451], 'indicated': [2453], 'arrow': [2456], '3.': [2459], 'Note': [2460], 'evolved': [2464], 'near': [2466], 'optimal': [2467, 3036, 3059, 3241], 'whereas': [2469, 3748, 4136], 'sub-optimal': [2474], 'rates.': [2475], 'Effect': [2477], 'External': [2479], 'NO—Binding': [2480], 'solution': [2481, 2539, 2606], 'becomes': [2487, 2698, 3568], 'significant': [2488], 'low': [2490, 3600, 3734], 'micromolar': [2491], 'concentrations.': [2493], 'equilibrium': [2495], 'event': [2497], 'differs': [2498, 4244], 'newly': [2503], 'generated': [2504], 'pocket.': [2513], 'Solution': [2514, 3676], 'particularly': [2518, 3569], 'important': [2519, 3570], 'predominates': [2527], '(as': [2531], 'iNOS).': [2535], 'circumstance,': [2538], 'concentration': [2544, 2696, 2716, 3564, 3607], 'alters': [2551], '4A).': [2557], 'It': [2558, 4233], 'leads': [2559], 'greater': [2561, 3107, 3196], 'shunts': [2570], 'through': [2573], 'cycle,': [2576], 'consequently': [2578], 'lowers': [2579], 'rate.': [2583, 3824], 'considerably': [2589], 'measured': [2593], 'presence': [2596], 'absence': [2598], 'scavenger.': [2602], 'effect': [2604, 3181], 'documented': [2610], '(28Abu-Soud': [2615, 3692], 'circumstances': [2686], 'result.': [2688], '1': [2693], 'μm': [2694], 'equally': [2699], 'efficient': [2700], 'generating': [2702], 'scavenging': [2704], '4B).': [2707, 2795], 'maintain': [2712], 'environment': [2719, 4248], 'even': [2720], 'while': [2721], 'supports': [2723], 'almost': [2724, 3603], 'no': [2725], 'net': [2726], 'At': [2769], 'higher': [2770, 3514, 3750], 'concentrations,': [2772], 'NADPH-dependent': [2783], 'oxygenase': [2785, 3257, 4138], 'expense': [2788], 'depends': [2798, 4216], 'interplay': [2800], 'kd.': [2805], 'With': [2806], 'mind,': [2809], 'we': [2810, 4083], 'provide': [2811], 'examples': [2813], 'behavior': [2817], 'could': [2819, 3870, 4227], 'understood': [2822], 'context': [2825], 'parameters.': [2835], 'More': [2836], 'Is': [2837, 3063], 'Less:': [2838], 'Case': [2840, 3066], 'S1412D': [2842, 2958, 2985, 3031], 'nNOS—Both': [2843], 'contain': [2847, 3071], 'consensus': [2849], 'sequence': [2850], 'Akt-dependent': [2852], 'Ser': [2853, 2900], 'phosphorylation': [2854], 'C-terminal': [2857], 'regulatory': [2858], 'elements': [2859], '(8Roman': [2860], '9Nedvetsky': [2876], 'Phosphorylation': [2897], 'mutation': [2903, 2916, 3032], 'Asp)': [2905], 'caused': [2906], '3-fold': [2908], 'activity.': [2912], 'identical': [2914], '(S1412D)': [2919], 'lowered': [2920], '30%': [2926], '(31Adak': [2927, 2999], 'Analysis': [2955], 'showed': [2956], 'actually': [2960, 3136], 'wild': [2966, 3143, 3160, 3201], 'type': [2967, 3144], 'therefore': [2971], 'Calmodulin': [2976], 'mutants': [2977, 3135, 3193], 'down': [2982, 2989], 'nNOS.': [2986, 3038], 'slowed': [2988], 'increased': [2994, 3033, 3163, 3940], 'occurs': [3028, 3349, 3584], 'because': [3029, 3053, 3237, 3315, 3525, 3819], 'beyond': [3035, 3240], 'increasing': [3040, 3238, 3810], 'same': [3046], 'should': [3048], 'basal': [3055], 'below': [3058], 'Less': [3062], 'More:': [3064], 'W409F': [3068], 'nNOS—Most': [3069], 'Trp': [3073], 'residue': [3074], 'whose': [3075, 3100], 'side': [3076], 'chain': [3077], 'hydrogen': [3080], 'bond': [3081], 'thiolate': [3085], 'ligand': [3086], '4C).': [3088, 3178], 'Substituting': [3089], 'Phe': [3090], 'Tyr': [3092], 'Trp-409': [3094, 3134, 3192, 3889], 'created': [3097], 'mutant': [3098], '2–5': [3105], 'wild-type': [3109], '(32Adak': [3111], 'decreased': [3139], 'compared': [3141, 3217], 'I).': [3151, 3522], 'Although': [3152, 4205], 'slower': [3158, 3187], 'type,': [3161], 'less': [3166], 'populate': [3169], '“positive”': [3180], 'overcomes': [3185, 3454], 'type.': [3202], 'Why': [3203], 'Do': [3204], 'Slow': [3207], 'Reduction': [3209], 'Rates?—Other': [3210], 'suggesting': [3223, 3669], 'under': [3227, 3745], 'unique': [3229], 'selective': [3230], 'pressure.': [3231], 'Their': [3232], 'understandable,': [3236], 'partition': [3243], 'convert': [3252], 'difficult': [3266], 'couple': [3270], 'oxygen': [3271, 3396, 3451, 3493, 3563], 'activation': [3272, 3397, 3494], 'substrate': [3274], 'oxidation': [3275, 4219], '33Adak': [3291], '33554-33561Abstract': [3302], '(214)': [3310], 'delivery': [3316], 'rapid': [3326], 'enough': [3327], 'generate': [3332], 'heme-oxy': [3334, 3916, 3944], 'autoxidation': [3344], 'ferricsuperoxy': [3346], 'solves': [3353], 'dilemma': [3355], 'utilizing': [3357], 'source': [3361], 'electron.': [3365], 'delivers': [3367], '3–30': [3372], 'flavoprotein,': [3379], 'difference': [3382], 'minimize': [3386, 3473], 'enable': [3394], 'coupled': [3395, 3450], '(20Wang': [3398], 'imposes': [3439], 'constraint': [3442], 'activation.': [3452], 'problem': [3456], 'kinetically': [3460, 3488], 'distinct': [3461], 'sources': [3462], 'electrons:': [3464], 'cycling,': [3479], 'sensitive': [3489], 'cascade.': [3495], 'Unusual': [3497], 'Response': [3499], 'NOSs—Apparent': [3501], 'KmO2': [3502, 3596, 3617, 3687, 3735, 3752], 'some': [3510, 4026], 'cases': [3511], 'much': [3513], 'those': [3516], 'reported': [3517], 'monooxygenases': [3520, 3954], 'interacts': [3527], 'ways;': [3532], 'biosynthesis,': [3540], '(kox).': [3553], 'Both': [3554], 'combine': [3556], 'determine': [3558], 'apparent': [3560, 3595, 3616, 3686, 3751], 'KmO2.': [3561], 'dependence': [3565], 'builds': [3576], 'up': [3577], 'state.': [3581], 'naturally': [3585], 'reflects': [3602], 'entirely': [3604], 'response': [3608], 'high': [3615], 'holds': [3620], 'whole': [3625], 'animals': [3626], 'tissues': [3628], '(34Prabhakar': [3629], 'N.R.': [3630], 'Kumar': [3631], 'G.K.': [3632], 'Chang': [3633], 'C.H.': [3634], 'Agani': [3635], 'F.H.': [3636, 3766], 'Haxhiu': [3637], 'Brain': [3639], 'Res.': [3640], '1993;': [3641], '625:': [3642], '16-22Crossref': [3643], '(152)': [3646], '35Elayan': [3649], 'I.M.': [3650], 'Axley': [3651], 'M.J.': [3652], 'Prasad': [3653], 'P.V.': [3654], 'Ahlers': [3655], 'S.T.': [3656], 'Auker': [3657], 'C.R.': [3658, 4115], 'Neurophysiol.': [3660], '83:': [3662], '2022-2029Crossref': [3663], '(132)': [3666], 'A': [3733], 'required': [3738], 'blood': [3743], 'supply': [3744], 'hypoxic': [3746], 'conditions,': [3747], 'explains': [3755], 'regulate': [3759], 'ventilation-perfusion': [3760], 'matching': [3761], 'lung': [3764], '(36Guo': [3765], 'De': [3767], 'Raeve': [3768], 'H.R.': [3769], 'Rice': [3770], 'Thunnissen': [3774], 'F.B.': [3775], 'Erzurum': [3776], '92:': [3786], '7809-7813Crossref': [3787], '(452)': [3790], 'Different': [3793], 'Strategies': [3794], 'Increase': [3796], 'Release—NOSs': [3798], 'likely': [3800], 'mechanisms.': [3807], 'sense': [3814], 'suboptimal': [3823], 'Indeed,': [3825], 'activators': [3827], 'phosphorylation,': [3829], 'HSP': [3830], '90,': [3831], 'dynamin': [3833], '10Greif': [3855], 'way.': [3873], 'better': [3877], 'strategy': [3878], 'would': [3879], 'demonstrated': [3886], 'mutants.': [3891], 'Whether': [3892], 'mechanisms': [3893], 'do': [3896, 4007], 'cells': [3899], 'now': [3901], 'investigated.': [3903], 'There': [3904], 'gaps': [3906], 'our': [3908], 'understanding': [3909], 'demonstrated.': [3927], 'require': [3930], 'and/or': [3941], 'stabilized,': [3947], 'perhaps': [3948], 'strategies': [3950], 'developed': [3951], 'other': [3953], '(37Dmochowski': [3955], 'I.J.': [3956], 'Dunn': [3957], 'Wilker': [3959], 'J.J.': [3960], 'Green': [3963], 'M.T.': [3964], 'Sligar': [3967, 3987], 'S.G.': [3968, 3988], 'Winkler': [3969], 'J.R.': [3970], 'Gray': [3971], 'H.B.': [3972], 'Methods': [3973], 'Enzymol.': [3974], '357:': [3976], '120-133Crossref': [3977], '(13)': [3980], '38Benson': [3983], 'Suslick': [3985], 'K.S.': [3986, 4095], '1997;': [3990], '36:': [3991], '5104-5107Crossref': [3992], '(89)': [3995], 'prompts': [4002], 'own': [4004], 'questions.': [4005], 'How': [4006], 'throughout': [4017], 'animal': [4019], 'kingdom?': [4020], 'Are': [4021], 'set': [4028], 'favor': [4030], 'release?': [4036], 'Bacterial': [4037], 'configured': [4041], 'way': [4043], '(39Wang': [4044], 'Pant': [4050], '2004;': [4059], '279:': [4060], '19018-19025Abstract': [4061], '(57)': [4069], 'What': [4072], 'physical': [4075], 'basis': [4076], 'parameters?': [4081], 'Presently,': [4082], 'know': [4085], 'determines': [4090, 4140], '(40Adak': [4092], 'Aulak': [4094], '23246-23252Abstract': [4103], '(45)': [4111], '41Nishida': [4114], 'Ortiz': [4116], 'de': [4117], 'Montellano': [4118], '273:': [4124], '5566-5571Abstract': [4125], '(95)': [4133], 'wide': [4167], 'variation': [4168], 'suggests': [4179], 'structure-function': [4182], 'relationships': [4183], 'remain': [4184], 'explored.': [4187], 'signaling': [4191], 'cytotoxicity': [4193], 'linked': [4197], 'cycles.': [4204], 'written': [4206], 'nitrate,': [4208], 'identity': [4210], 'cytotoxic': [4230], 'molecule': [4231], 'peroxynitrite.': [4232], 'see': [4238], 'release,': [4242], 'according': [4245], 'correlates': [4255], 'physiologic': [4258], 'roles.': [4259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026623916', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 22}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 34}], 'updated_date': '2024-12-10T00:39:31.551368', 'created_date': '2016-06-24'}
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