Publication Information

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2547, 2555, 2584, 2597, 2600, 2607, 2613, 2624, 2632, 2672, 2675, 2682, 2689, 2708, 2711, 2718, 2724, 2798, 2827, 2838, 2850, 2854, 2871, 2886, 2960, 3075, 3080, 3185, 3283, 3323, 3362, 3370, 3379, 3466, 3483, 3493, 3580, 3588, 3600, 3643, 3692, 3747, 3776, 3799, 3816, 3833, 3867, 3923, 3926, 3930, 3936, 3951, 3983, 4012, 4032, 4049, 4058, 4070, 4091, 4100, 4112, 4138, 4147, 4159, 4179, 4188, 4201, 4239, 4290, 4300, 4317, 4325, 4335, 4352, 4360, 4370, 4393, 4404, 4454], 'transcription': [3, 238, 472, 827, 1010], 'factor': [4, 239, 473], 'PDX-1': [5, 13, 42, 57, 88, 204, 225, 240, 248, 277, 292, 323, 439, 460, 474, 667, 681, 824, 1003, 1051, 1281, 1298, 1323, 1450, 1565, 1587, 1603, 1621, 1643, 1649, 1665, 1692, 2038, 2173, 2211, 2832, 2872, 3128, 3325, 3446, 3461, 3601, 3630, 3800, 4013, 4240], 'leads': [6, 241, 1013, 1452], 'to': [7, 99, 115, 160, 168, 180, 242, 334, 350, 395, 403, 415, 1014, 1053, 1244, 1279, 1327, 1453, 2098, 2282, 2340, 2361, 2538, 2604, 2679, 2694, 2715, 2729, 2753, 2859, 3095, 3098, 3116, 3146, 3200, 3290, 3327, 3329, 3485, 3566, 3606, 3670, 3675, 3710, 3767, 3792, 3809, 3862, 3878, 3962, 3979, 3995, 4042, 4084, 4131, 4173, 4223, 4261, 4281, 4310, 4345, 4387, 4410, 4434, 4439], 'pancreatic': [8, 69, 233, 243, 304, 468, 673, 683, 1016, 1591, 2270, 2614, 2625, 2696, 2741, 3315, 3359, 3368, 3638, 3677], 'agenesis,': [9, 244], 'whereas': [10, 104, 245, 339, 3376, 3617], 'heterozygosity': [11, 246], 'for': [12, 145, 228, 247, 380, 463, 1226, 1590, 1652, 1744, 1809, 1820, 1892, 1903, 1918, 2085, 2123, 2288, 2292, 2825, 3124, 3189, 3205, 3358, 3683, 3705, 3890, 4267], 'mutations': [14, 249, 1321, 3125], 'has': [15, 250, 2527, 2593], 'been': [16, 251], 'recently': [17, 252], 'noted': [18, 253], 'in': [19, 30, 41, 53, 93, 113, 121, 125, 150, 158, 203, 208, 254, 265, 276, 288, 328, 348, 356, 360, 385, 393, 438, 443, 498, 672, 1005, 1050, 1055, 1060, 1242, 1322, 1439, 1558, 1561, 1604, 1607, 1622, 1637, 1656, 1664, 1721, 1735, 1800, 1805, 1836, 1852, 1944, 2109, 2116, 2144, 2268, 2326, 2350, 2352, 2418, 2429, 2582, 2732, 2739, 2896, 2956, 3016, 3035, 3044, 3055, 3101, 3126, 3144, 3209, 3257, 3293, 3299, 3304, 3307, 3385, 3451, 3513, 3518, 3550, 3553, 3558, 3569, 3585, 3637, 3659, 3673, 3700, 3708, 3719, 3738, 3807, 3914, 3960, 3969, 3974, 3988, 4001, 4005, 4026, 4037, 4046, 4060, 4072, 4088, 4102, 4114, 4126, 4135, 4149, 4161, 4176, 4190, 4203, 4228, 4232, 4259, 4292, 4302, 4314, 4327, 4337, 4349, 4362, 4372, 4388, 4408, 4421, 4432], 'some': [20, 31, 255, 266, 2382, 3570], 'individuals': [21, 32, 256, 267, 1326, 3211], 'with': [22, 33, 55, 139, 257, 268, 290, 374, 1007, 1639, 1686, 1769, 1841, 1884, 1984, 2028, 2160, 2171, 2217, 2226, 2235, 2253, 2381, 2440, 2499, 2565, 2641, 2648, 2668, 2705, 2831, 2835, 2840, 2867, 3021, 3105, 3250, 3445, 3460, 3502, 3613, 3650, 3814, 3852, 3887, 3977], 'maturity-onset': [23, 258, 1231], 'diabetes': [24, 259, 843, 1026, 1059, 1232, 1332], 'the': [26, 166, 261, 401, 489, 499, 845, 1028, 1227, 1234, 1562, 1597, 1600, 1608, 1618, 1623, 1657, 1682, 1687, 1691, 1760, 1764, 1907, 2172, 2176, 2249, 2269, 2305, 2327, 2336, 2362, 2386, 2390, 2393, 2396, 2403, 2407, 2409, 2419, 2430, 2556, 2562, 2585, 2638, 2733, 2754, 2836, 2851, 2888, 2897, 2945, 2957, 3056, 3102, 3127, 3183, 3190, 3248, 3258, 3264, 3302, 3318, 3324, 3367, 3377, 3491, 3625, 3641, 3667, 3676, 3681, 3690, 3703, 3711, 3739, 3774, 3859, 3911, 3968, 3980, 4002, 4010, 4027, 4047, 4089, 4136, 4177, 4229, 4237, 4315, 4350, 4391, 4402, 4422], 'young': [27, 262, 1029, 1235], '(MODY)': [28, 263], 'and': [29, 50, 68, 77, 89, 101, 153, 184, 193, 223, 264, 285, 303, 312, 324, 336, 388, 419, 428, 458, 480, 491, 494, 675, 678, 856, 1012, 1018, 1058, 1062, 1237, 1444, 1521, 1568, 1582, 1593, 1613, 1633, 1659, 1670, 1725, 1734, 1754, 1822, 1845, 1898, 1936, 1958, 2017, 2113, 2139, 2152, 2168, 2212, 2224, 2233, 2265, 2290, 2294, 2310, 2343, 2355, 2398, 2402, 2467, 2475, 2520, 2617, 2658, 2899, 2922, 2984, 3013, 3024, 3039, 3048, 3062, 3078, 3132, 3285, 3479, 3509, 3568, 3583, 3602, 3609, 3645, 3679, 3726, 3756, 3838, 3872, 3892, 3898, 3920, 3943, 3949, 3964, 3990, 3999, 4017, 4029, 4225, 4247, 4264, 4269, 4275, 4415, 4450], 'type': [34, 152, 269, 387, 1330, 1583, 1729, 2325, 2829, 2901, 3278, 3504, 3615, 3721, 3778, 3818, 4020, 4250, 4406], '2': [35, 92, 270, 327, 1038, 1331, 1584, 1801], 'diabetes.': [36, 271, 1585], 'To': [37, 272, 1615, 3262, 3623, 3733, 3909, 4417], 'determine': [38, 273, 2695], 'how': [39, 274], 'alterations': [40, 275], 'affect': [43, 278], 'islet': [44, 51, 279, 286, 471, 830, 857, 1009, 1019, 1033, 1056, 1594, 1605, 1634, 1654, 2101, 2328, 3287, 3474, 3565, 3678, 3687, 3836], 'function,': [45, 217, 280, 452], 'we': [46, 281, 1626, 3280, 3742, 3956, 4428], 'examined': [47, 282, 3281, 3743, 4429], 'insulin': [48, 70, 80, 136, 146, 177, 210, 283, 305, 315, 371, 381, 412, 445, 490, 847, 1031, 1046, 1240, 1631, 1671, 2183, 2223, 2491, 2503, 2506, 2522, 2576, 2589, 3091, 3142, 3201, 3273, 3284, 3305, 3360, 3634, 3693, 3706, 3915, 3952, 3958, 3975, 4035, 4059, 4071, 4101, 4113, 4124, 4148, 4160, 4189, 4202, 4291, 4301, 4326, 4336, 4361, 4371, 4400, 4423, 4430], 'secretion': [49, 157, 211, 284, 392, 446, 1032, 1241, 3306, 3635, 3959, 4008, 4036, 4125, 4235, 4424, 4431], 'physiology': [52, 287], 'mice': [54, 61, 131, 289, 296, 366, 1063, 1567, 1638, 1674, 1724, 1742, 1756, 2830, 2942, 2961, 3009, 3031, 3034, 3043, 3243, 3249, 3269, 3309, 3387, 3471, 3520, 3590, 3647, 3758, 3819, 4062, 4074, 4104, 4116, 4153, 4163, 4192, 4205, 4294, 4329, 4364, 4395], 'one': [56, 291, 1449, 1640, 2868], 'allele': [58, 293, 1451, 1641, 2870], 'inactivated.': [59, 294, 1644], 'PDX-1+/−': [60, 122, 130, 154, 295, 357, 365, 389, 1723, 1755, 2898, 2913, 2972, 2993, 3008, 3081, 3103, 3242, 3268, 3308, 3363, 3470, 3589, 3646, 3701, 3757, 3873, 4073, 4115, 4162, 4204, 4303, 4338, 4373, 4394], 'had': [62, 73, 297, 308, 3010, 3064, 3084, 3270], 'a': [63, 200, 298, 435, 669, 1293, 1555, 1577, 1661, 1816, 1945, 2254, 2333, 2353, 2415, 2426, 2441, 2468, 2495, 2528, 2571, 2594, 2669, 2686, 2746, 3011, 3052, 3203, 3452, 3455, 3480, 3651, 3760], 'normal': [64, 229, 299, 464, 1015, 1653, 1667, 2162, 2509, 2654, 3085, 3135, 3251, 3473, 3481], 'fasting': [65, 300, 2889, 2946], 'blood': [66, 301, 2890, 3018], 'glucose': [67, 75, 82, 90, 116, 302, 310, 317, 325, 351, 1036, 1245, 1455, 1629, 1668, 2470, 2796, 2841, 2875, 2878, 2891, 2947, 3006, 3019, 3057, 3066, 3086, 3107, 3137, 3147, 3207, 3252, 3494, 3653, 3674, 3696, 3712, 3770, 3786, 3812, 3881, 3963, 4052, 4094, 4141, 4182, 4284, 4440], 'content': [71, 306, 1924, 2738, 3361, 3369, 3378], 'but': [72, 307, 2950, 3059, 3139], 'impaired': [74, 309, 1239, 1454, 1571, 2874, 3065, 3106], 'tolerance': [76, 83, 311, 318, 1456, 1732, 2879, 3108, 3253], 'secreted': [78, 132, 313, 367], 'less': [79, 135, 314, 370, 3699, 3805, 4399], 'during': [81, 316, 1596, 2553, 2630, 2877, 3686, 3714, 3765], 'testing.': [84, 319, 1748], 'The': [85, 124, 143, 320, 359, 378, 470, 1645, 1830, 1879, 2005, 2024, 2083, 2156, 2320, 2421, 2433, 2446, 2480, 2525, 2795, 2818, 3068, 3556, 3578, 3856, 4039, 4081, 4128, 4170, 4278, 4452], 'expression': [86, 106, 321, 341, 1560, 1572, 1636, 3282, 3492, 3515, 3552, 3560, 3573, 3579, 3619], 'transporter': [91, 326, 851, 1037, 3495], 'islets': [94, 329, 1563, 1941, 2271, 3505, 3571, 3587, 3749, 3798, 3815, 3825, 3834, 3848, 3877], 'from': [95, 330, 495, 1752, 2068, 2096, 2242, 2280, 2478, 2486, 2561, 2637, 2749, 3070, 3118, 3182, 3468, 3564, 3754, 3789, 3824, 3938, 3953, 3967, 4009, 4236], 'PDX-1+/−mice': [96, 331], 'was': [97, 107, 117, 148, 164, 173, 332, 342, 352, 383, 399, 408, 482, 1833, 1881, 1909, 1916, 2074, 2107, 2312, 2329, 2348, 2412, 2435, 2485, 2492, 2568, 2644, 2692, 2727, 2743, 2759, 2801, 2823, 3051, 3372, 3381, 3497, 3561, 3574, 3591, 3604, 3620, 3698, 3717, 3782, 3787, 4024, 4053, 4095, 4142, 4183, 4257, 4285, 4320, 4355], 'reduced': [98, 118, 190, 333, 353, 425, 3094, 3314, 3382, 3498, 3605], '68': [100, 335, 3608], '55%,': [102, 337, 3610], 'respectively,': [103, 338, 3611], 'glucokinase': [105, 340, 835, 1023], 'not': [108, 343, 2894, 3255, 3311, 3522, 3895, 4272], 'significantly': [109, 189, 344, 424, 3150, 3896, 4273], 'altered.': [110, 345], 'NAD(P)H': [111, 214, 346, 449, 2757, 2799, 3745, 3806, 3830], 'generation': [112, 347], 'response': [114, 159, 167, 349, 394, 402, 1243, 2797, 3145, 3709, 3808, 3823, 3866, 3961, 3994, 4041, 4083, 4130, 4172, 4222, 4260, 4280, 4309, 4344, 4409, 4433], 'by': [119, 354, 1283, 1680, 1757, 1767, 1920, 1982, 2000, 2092, 2274, 2494, 2570, 2646, 2761, 2803, 2847, 3246, 3266, 3295, 3313, 3374, 3383, 3594, 3628, 3827], '30%': [120, 355, 3074, 3804], 'mice.': [123, 155, 358, 390, 3364, 3448, 3463, 3555, 3732, 4033], 'situ': [126, 361, 2351, 3660, 3970], 'perfused': [127, 362, 2349, 2413, 3971, 4004, 4231], 'pancreas': [128, 363, 1765, 1832, 2347, 2558, 2564, 2634, 2640, 3642, 3661, 3715, 3984, 4003, 4011, 4230, 4238, 4392, 4403], 'about': [133, 368, 3607, 3803, 4397], '45%': [134, 369, 4398], 'when': [137, 372, 2543, 2609, 2620, 2684, 2720, 3785], 'stimulated': [138, 373], '16.7': [140, 375, 4282, 4411], 'mm': [141, 162, 182, 186, 376, 397, 417, 421, 1951, 1956, 1960, 3769, 3791, 3794, 3811, 3843, 3854, 3880, 4051, 4093, 4140, 4181, 4283, 4312, 4347], 'glucose.': [142, 377, 3331, 3844, 3855], 'Km': [144, 379, 3704], 'release': [147, 382, 3707], 'similar': [149, 384, 3097, 3115, 3356, 3548, 3718], 'wild': [151, 386, 1728, 2828, 2900, 3277, 3503, 3614, 3720, 3777, 3817, 4019, 4249, 4405], 'Insulin': [156, 391, 2551, 4007, 4234], '20': [161, 185, 396, 420, 2722, 3793, 3810, 3853, 3879, 4132, 4346, 4358], 'arginine': [163, 398], 'unchanged;': [165, 400], '10': [169, 181, 404, 416, 4043, 4085, 4174, 4311], 'nm': [170, 405, 4044, 4086, 4133], 'glucagon-like': [171, 406, 1040, 2481, 3996], 'peptide-1': [172, 407, 1041], 'slightly': [174, 409, 3576], 'increased.': [175, 410], 'However,': [176, 411, 3004, 3490, 3797], 'secretory': [178, 413, 3954, 3993, 4221], 'responses': [179, 414, 3746], '2-ketoisocaproate': [183, 418, 1045, 2473, 4224], 'KCl': [187, 422, 4348], 'were': [188, 423, 1675, 1719, 1739, 1750, 1798, 1825, 1942, 1998, 2011, 2026, 2067, 2090, 2103, 2133, 2142, 2158, 2215, 2251, 2272, 2286, 2423, 2477, 2845, 2857, 2893, 2952, 3093, 3244, 3254, 3516, 3648, 3894, 3899, 4271, 4276], '(by': [191, 426], '61': [192, 427], '66%,': [194, 429], 'respectively).': [195, 430], 'These': [196, 431], 'results': [197, 432, 1646, 3357], 'indicate': [198, 433, 1319, 1647], 'that': [199, 224, 434, 459, 666, 676, 1291, 1320, 1570, 1648, 1660, 3073, 3195], 'modest': [201, 436, 1662], 'reduction': [202, 437, 1557, 1663, 3557], 'impairs': [205, 440, 1666], 'several': [206, 441, 662, 4435], 'events': [207, 442, 3737, 3913], 'glucose-stimulated': [209, 444, 1030, 3633], '(such': [212, 447], 'as': [213, 448, 477, 485, 833, 1677, 2296, 2332, 2766, 2814, 3030, 3918, 4445], 'generation,': [215, 450], 'mitochondrial': [216, 451, 3921], 'and/or': [218, 453], 'mobilization': [219, 454, 3935], 'intracellular': [221, 456, 3939], 'Ca2+)': [222, 457], 'is': [226, 461, 1021, 1277, 1588, 1610, 1650, 3113, 3202, 3310], 'important': [227, 462], 'function': [230, 465, 1057, 1606, 1655], 'adult': [232, 467, 1609, 1658], 'islets.': [234, 469], '(also': [475], 'known': [476, 3289], 'IPF-1,': [478], 'IDX-1,': [479], 'STF-1)': [481], 'originally': [483], 'discovered': [484], 'an': [486, 1285, 1885, 2020, 2029, 2077, 2706, 3321, 3658], 'activator': [487], 'somatostatin': [492, 1047, 2234], 'genes': [493, 831, 3288], 'developmental': [496], 'work': [497], 'frog': [500], '(1.Habener': [501, 685, 861, 1064], 'J.F.': [502, 644, 686, 787, 813, 862, 890, 1065, 1082, 1106, 1130, 1210, 1263, 1304, 1341, 1365, 3165, 3229], 'Stoffers': [503, 687, 863, 1066, 1119, 1197, 1250, 1354, 3154, 3216], 'D.A.': [504, 640, 688, 783, 805, 864, 886, 1067, 1078, 1100, 1120, 1198, 1251, 1300, 1335, 1355, 3155, 3217], 'Proc.': [505, 689, 865, 1068], 'Assoc.': [506, 690, 866, 1069], 'Am.': [507, 691, 867, 1070], 'Physicians.': [508, 692, 868, 1071], '1998;': [509, 517, 631, 693, 701, 774, 869, 877, 1072, 1185, 1308, 1460, 1493, 1510, 1526, 1546, 3347, 3539], '110:': [510, 694, 870, 1073], '12-21PubMed': [511, 695, 871, 1074], 'Google': [512, 523, 540, 561, 581, 594, 617, 637, 659, 696, 707, 724, 737, 760, 780, 802, 822, 872, 883, 905, 931, 956, 974, 1000, 1075, 1097, 1115, 1142, 1174, 1191, 1220, 1273, 1314, 1350, 1377, 1409, 1436, 1466, 1479, 1499, 1516, 1532, 1552, 1716, 1792, 1877, 1980, 2379, 2793, 3177, 3239, 3353, 3545], 'Scholar,': [513, 524, 541, 562, 582, 595, 618, 638, 697, 708, 725, 738, 761, 781, 803, 873, 884, 906, 932, 957, 975, 1076, 1098, 1116, 1143, 1175, 1192, 1351, 1378, 1410, 1467, 1480, 1500, 1533], '2.Edlund': [514, 698, 874], 'H.': [515, 532, 588, 628, 699, 716, 731, 771, 875, 934, 942, 977, 981, 1420, 1458, 1473, 1490, 1524, 1543, 3344, 3536], 'Diabetes.': [516, 700, 876, 951, 1213, 1266, 1459, 1525, 1872, 2374, 3232], '47:': [518, 702, 878, 1461, 1527], '1817-1823Crossref': [519, 703, 879, 1462, 1528], 'PubMed': [520, 560, 580, 593, 616, 634, 656, 704, 736, 759, 777, 799, 819, 880, 902, 928, 955, 971, 997, 1094, 1112, 1139, 1171, 1188, 1217, 1270, 1311, 1347, 1374, 1406, 1463, 1478, 1496, 1513, 1529, 1549, 1715, 1789, 1876, 1977, 2378, 2790, 3174, 3236, 3350, 3542], 'Scopus': [521, 635, 657, 705, 778, 800, 820, 881, 903, 929, 972, 998, 1095, 1113, 1140, 1172, 1189, 1218, 1271, 1312, 1348, 1375, 1407, 1464, 1497, 1514, 1530, 1550, 1790, 1978, 2791, 3175, 3237, 3351, 3543], '(276)': [522, 706, 882, 1465, 1531], '3.Jonsson': [525, 709], 'J.': [526, 534, 549, 564, 586, 622, 710, 718, 729, 765, 917, 1102, 1133, 1305, 1337, 1368, 1429, 1471, 1484, 1537, 1783, 1867, 1971, 2779, 3168, 3338, 3530], 'Ahlgren': [527, 711, 3332, 3524], 'U.': [528, 584, 620, 712, 727, 763, 1469, 1482, 1535, 3336, 3528], 'Edlund': [529, 531, 587, 627, 713, 715, 730, 770, 1472, 1489, 1520, 1542, 3343, 3535], 'T.': [530, 568, 714, 940, 946, 983, 1426], 'Int.': [533, 717], 'Dev.': [535, 630, 719, 773, 1492, 1545, 3346, 3538], 'Biol.': [536, 720, 918, 2780], '1995;': [537, 557, 721, 1873], '39:': [538, 722], '789-798PubMed': [539, 723], '4.Guz': [542], 'Y.': [543, 936, 938, 944, 950, 979, 985, 989, 1776, 1861], 'Montminy': [544, 573, 1180, 1505], 'M.R.': [545, 574, 1181, 1506], 'Stein': [546, 604, 747, 913, 1703], 'R.': [547, 914, 948], 'Leonard': [548], 'Gamer': [550], 'L.W.': [551], 'Wright': [552, 610, 753, 1182, 1507, 1709], 'C.V.': [553, 1183, 1508], 'Teitelman': [554], 'G.': [555, 959], 'Development.': [556, 589, 612, 732, 755, 1474, 1711], '121:': [558], '11-18Crossref': [559], '5.Leonard': [563], 'Peers': [565], 'B.': [566, 1964], 'Johnson': [567], 'Ferreri': [569], 'K.': [570, 626, 769, 1488, 1541, 3342, 3534], 'Lee': [571], 'S.': [572, 1149, 1157, 1177, 1179, 1384, 1392, 1414, 1502, 1504, 1869], 'Mol.': [575, 966], 'Endocrinol.': [576, 646, 789, 892, 967, 1084, 1431], '1993;': [577], '7:': [578], '1275-1283Crossref': [579], '6.Ahlgren': [583, 726, 1468], 'Jonsson': [585, 621, 623, 728, 764, 766, 1470, 1483, 1485, 1536, 1538, 3337, 3339, 3529, 3531], '1996;': [590, 613, 733, 756, 952, 968, 994, 1475, 1712], '122:': [591, 614, 734, 757, 1476, 1713], '1409-1416Crossref': [592, 735, 1477], '7.Offield': [596, 739], 'M.F.': [597, 740, 1696], 'Jetton': [598, 741, 1697], 'T.L.': [599, 742, 1698], 'Labosky': [600, 743, 1699], 'P.A.': [601, 744, 1700], 'Ray': [602, 745, 1701], 'M.': [603, 746, 912, 1159, 1394, 1702, 1780, 2056], 'R.W.': [605, 748, 1704], 'Magnuson': [606, 749, 1705, 2777], 'M.A.': [607, 750, 1706, 2778], 'Hogan': [608, 751, 1707], 'B.L.M.': [609, 752, 1708], 'C.V.E.': [611, 754, 1710], '983-995Crossref': [615, 758, 1714], '8.Ahlgren': [619, 762, 1481, 1534], 'L.': [624, 767, 1412, 1486, 1539, 1782, 1863, 3340, 3532], 'Simu': [625, 768, 1487, 1540, 3341, 3533], 'Genes': [629, 772, 1491, 1544, 3345, 3537], '12:': [632, 775, 1494, 1547, 3348, 3540], '1763-1768Crossref': [633, 776, 1495, 1548, 3349, 3541], '(792)': [636, 779, 1498, 1551, 3352, 3544], '9.Stoffers': [639, 782, 885, 1077], 'Thomas': [641, 784, 887, 1079], 'M.K.': [642, 785, 888, 1080], 'Habener': [643, 786, 812, 889, 1081, 1105, 1129, 1209, 1262, 1303, 1340, 1364, 3164, 3228], 'Trends': [645, 788, 891, 1083], 'Metab.': [647, 790, 893, 1085, 1432], '1997;': [648, 791, 816, 894, 920, 1086, 1109, 1344], '8:': [649, 792, 895, 1087], '145-151Abstract': [650, 793, 896, 1088], 'Full': [651, 653, 794, 796, 897, 899, 923, 925, 1089, 1091, 2785, 2787], 'Text': [652, 654, 795, 797, 898, 900, 924, 926, 1090, 1092, 2786, 2788], 'PDF': [655, 798, 901, 927, 1093, 2789], '(96)': [658, 801, 904, 1096], 'Scholar).': [660, 823, 1001, 1221, 1274, 1315, 1437, 1517, 1717, 1793, 1878, 2794, 3178, 3240], 'Moreover,': [661], 'laboratories': [663], 'have': [664, 682, 1238, 1627, 2873, 3134], 'demonstrated': [665, 1554], 'plays': [668], 'key': [670], 'role': [671, 1601, 1619], 'development': [674, 1020, 1592], 'animals': [677], 'humans': [679, 1061], 'lacking': [680], 'agenesis': [684], '10.Stoffers': [804], 'Zinkin': [806], 'N.T.': [807], 'Stanojevic': [808, 1125, 1301, 1360, 3160], 'V.': [809, 1126, 1302, 1361, 2033, 2369, 3161], 'Clarke': [810, 1103, 1205, 1258, 1338, 3224], 'W.L.': [811, 1104, 1206, 1259, 1339, 3225], 'Nat.': [814, 1107, 1342], 'Genet.': [815, 1108, 1343], '15:': [817], '106-110Crossref': [818], '(956)': [821], 'also': [825, 3193], 'regulates': [826], 'other': [829, 1008, 3286], 'such': [832, 3917, 4444], 'GLUT2,': [834, 1935, 3582], '(GK),': [836], '1The': [837], 'abbreviations': [838], 'used': [839, 2693, 2824], 'are:': [840], 'GKglucokinaseMODYmaturity-': [841], 'onset': [842, 1025, 1329], 'youngGSISglucose-stimulated': [846], 'secretionIAPPislet': [848], 'amyloid': [849, 858, 1034], 'polypeptideGLUT2glucose': [850], '2RIAradioimmunoassayGLP-1glucagon-like': [852], 'peptide-1TPEMtwo-photon': [853], 'excitation': [854, 1043, 2763], 'microscopyKIC2-ketoisocaproateINSinsulinSOMsomatostatinGLUglucagon': [855], 'polypeptide': [859, 1035], '(IAPP)': [860], '11.Carty': [907], 'M.D.': [908], 'Lillquist': [909], 'J.S.': [910], 'Peshavaria': [911], 'Soeller': [915], 'W.C.': [916], 'Chem.': [919, 2781], '272:': [921], '11986-11993Abstract': [922], '(86)': [930], '12.Watada': [933], 'Kajimoto': [935, 978], 'Umayahara': [937], 'Matsuoka': [939, 982], 'Kaneto': [941, 980], 'Fujitani': [943, 984], 'Kamada': [945], 'Kawamori': [947], 'Yamasaki': [949, 988], '45:': [953], '1478-1488Crossref': [954], '13.Waeber': [958], 'Thompson': [960], 'N.': [961], 'Nicod': [962], 'P.': [963, 1132, 1161, 1367, 1396, 1424, 1778, 3167], 'Bonny': [964], 'C.': [965, 1128, 1363, 2032, 2774, 3163], '10:': [969], '1327-1334Crossref': [970], '(326)': [973], '14.Watada': [976], 'Miyazaki': [986], 'Ji': [987], 'Biochem.': [990], 'Biophys.': [991], 'Res.': [992], 'Commun.': [993], '229:': [995], '746-751Crossref': [996], '(87)': [999], 'How': [1002], 'functions': [1004], 'concert': [1006], 'factors': [1011], 'exocrine': [1017], 'unknown.': [1022], 'maturity-': [1024], 'radioimmunoassay': [1039, 1921], 'two-photon': [1042, 2762], 'microscopy': [1044, 2764], 'glucagon': [1048, 2225, 2697, 2703, 2731, 3371], 'Mutations': [1049], 'lead': [1052], 'abnormalities': [1054], '15.Stoffers': [1099], 'Ferrer': [1101, 1336], '17:': [1110, 1345], '138-139Crossref': [1111, 1346], '(8)': [1114, 1349], '16.Hani': [1117, 1352], 'E.H.': [1118, 1353, 3153], 'Chevre': [1121, 1356, 3156], 'J.C.': [1122, 1151, 1357, 1386, 3157], 'Durand': [1123, 1358, 3158], 'E.': [1124, 1359, 2034, 3159], 'Dina': [1127, 1362, 3162], 'Froguel': [1131, 1366, 3166], 'Clin.': [1134, 1166, 1306, 1369, 1401, 1430, 1784, 1972, 3169], 'Invest.': [1135, 1167, 1307, 1370, 1402, 1785, 1973, 3170], '1999;': [1136, 1168, 1371, 1403, 2782, 3171], '104:': [1137, 1169, 1372, 1404, 3172], 'R41-R48Crossref': [1138, 1373, 3173], '(275)': [1141, 1376, 3176], '17.Macfarlane': [1144, 1379], 'W.M.': [1145, 1380], 'Frayling': [1146, 1381], 'T.M.': [1147, 1382], 'Ellard': [1148, 1383], 'Evans': [1150, 1385], 'Allen': [1152, 1387], 'L.I.': [1153, 1388], 'Bulman': [1154, 1389], 'M.P.': [1155, 1390], 'Ayres': [1156, 1391], 'Shepherd': [1158, 1393], 'Clark': [1160, 1395], 'Millward': [1162, 1397], 'A.': [1163, 1398, 2373], 'et': [1164, 1399, 2366, 3333, 3525], 'al.J.': [1165, 1400], 'R33-R39Crossref': [1170, 1405], '(226)': [1173, 1408], '18.Dutta': [1176, 1501], 'Bonner-Weir': [1178, 1503, 1868], 'Nature.': [1184, 1509], '392:': [1186, 1511], '560Crossref': [1187, 1512], '(118)': [1190, 1515], '19.Clocquet': [1193], 'A.R.': [1194, 1247, 3213], 'Egan': [1195, 1248, 3214], 'J.M.': [1196, 1249, 3215], 'Muller': [1199, 1252, 3218], 'D.C.': [1200, 1253, 3219], 'Wideman': [1201, 1254, 3220], 'L': [1202, 1255, 3221], 'Chin': [1203, 1256, 3222], 'G.A.': [1204, 1257, 3223], 'Hanks': [1207, 1260, 1806, 3226], 'J.B.': [1208, 1261, 3227], 'Elahi': [1211, 1264, 3230], 'D.': [1212, 1265, 3231], '2000;': [1214, 1267, 1433, 3233], '49:': [1215, 1268, 3234], '1856-1864Crossref': [1216, 1269, 3235], '(61)': [1219, 1272, 3238], 'Individuals': [1222], 'who': [1223, 3121, 3133], 'are': [1224, 2812, 3122, 3149, 3986, 4426], 'heterozygous': [1225, 3123], 'Pro63fsdelC': [1228, 3191], 'mutation': [1229, 1276], 'develop': [1230], '(MODY4)': [1236], '(19.Clocquet': [1246, 3212], 'This': [1275, 2591, 3111, 3664], 'thought': [1278], 'reduce': [1280], 'activity': [1282], 'creating': [1284], 'alternate': [1286], 'internal': [1287], 'translation': [1288], 'start': [1289], 'site': [1290], 'produces': [1292], 'dominant': [1294], 'negative': [1295], 'isoform': [1296], '(20.Stoffers': [1299], '102:': [1309], '232-241Crossref': [1310], '(162)': [1313], 'Some': [1316], 'recent': [1317, 3180], 'reports': [1318], 'may': [1324], 'predispose': [1325], 'late': [1328], 'mellitus': [1333], '(15.Stoffers': [1334], '21.Hansen': [1411], 'Urioste': [1413], 'Petersen': [1415], 'H.V.': [1416], 'Jensen': [1417], 'J.N.': [1418], 'Eiberg': [1419], 'Barbetti': [1421], 'F.': [1422], 'Serup': [1423], 'Hansen': [1425], 'Pedersen': [1427], 'O.': [1428], '85:': [1434], '1323-1326PubMed': [1435], 'Similarly': [1438], 'murine': [1440], 'models': [1441], 'both': [1442, 3060], 'conventional': [1443], 'postnatal,': [1445], 'cell-specific': [1446], 'inactivation': [1447], '(2.Edlund': [1457, 1523], 'In': [1518, 2299, 2940, 3365, 3773], 'addition,': [1519], 'co-workers': [1522], 'Scholar)': [1553, 1981, 2380, 3354, 3546], 'striking': [1556], 'GLUT2': [1559, 1574, 2043, 2177, 2213, 3496, 3514, 3551, 3559, 3572, 3603], 'heterozygote': [1566, 2833, 3727], 'suggested': [1569], 'might': [1575], 'be': [1576, 2860, 3291], 'general': [1578], 'cause': [1579], 'hyperglycemia': [1581], 'Whereas': [1586, 3689], 'crucial': [1589], 'formation': [1595], 'fetal': [1598], 'period,': [1599, 1625], 'incompletely': [1611], 'defined': [1612], 'characterized.': [1614], 'better': [1616], 'understand': [1617], 'postnatal': [1624], 'studied': [1628], 'tolerance,': [1630], 'secretion,': [1632, 3916], 'protein': [1635, 1923, 1926, 2003, 2087], 'required': [1651], 'sensing': [1669], 'secretion.': [1672], 'PDX-1-deficient': [1673, 3386, 3554], 'generated': [1676, 3802], 'described': [1678, 2297, 2767, 3260], 'earlier': [1679], 'fusing': [1681], 'lacZ': [1683], 'reporter': [1684], 'gene': [1685, 3129], 'N': [1688], 'terminus': [1689], 'coding': [1693], 'region': [1694], '(7.Offield': [1695], 'Studies': [1718], 'performed': [1720, 1740, 2075, 2760], '8–40-week-old': [1722], 'their': [1726, 3017, 3089, 3140, 3276, 4018, 4248], 'age-matched,': [1727], 'littermates.': [1730], 'Glucose': [1731], 'tests': [1733], 'situpancreas': [1736], 'perfusion': [1737, 2434, 2554, 2631, 2839, 3662, 3716], 'studies': [1738, 3259], 'on': [1741, 2013, 2088, 2135], 'fasted': [1743], '14–16': [1745], 'h': [1746, 1894, 2125], 'before': [1747], 'Islets': [1749, 1819, 3752], 'isolated': [1751, 1940, 3586, 3748, 3753], 'PDX-1+/+': [1753, 2985, 3022, 3644, 3755, 3868, 4061, 4103, 4191, 4293, 4328, 4363], 'dissection': [1758], 'splenic': [1761, 2394], 'portion': [1762], 'followed': [1766], 'digestion': [1768, 3685], 'collagenase': [1770], 'P': [1771], '(Roche': [1772], 'Molecular': [1773], 'Biochemicals)': [1774], '(22.Stefan': [1775], 'Meda': [1777], 'Neufeld': [1779], 'Orci': [1781], '1987;': [1786], '80:': [1787], '175-183Crossref': [1788], '(141)': [1791], 'Groups': [1794], 'two': [1796, 3847], 'pancreases': [1797, 2285, 3467], 'digested': [1799], 'mg': [1802], 'collagenase/pancreas': [1804], 'buffered': [1807], 'saline': [1808, 2112, 2146], '6–9': [1810], 'min': [1811], 'at': [1812, 1895, 1900, 1911, 1988, 2061, 2126, 2208, 2437, 2862, 3841, 3858], '37': [1813], '°C': [1814, 1897, 1913], 'using': [1815, 2076, 2314, 2544, 2575, 2610, 2621, 2685, 2721, 2745, 2807, 3657, 3750], 'wrist-action': [1817], 'shaker.': [1818], 'immunoblotting': [1821], 'further': [1823, 3592, 3734], 'analysis': [1824, 2806, 2853, 3596], 'handpicked': [1826], 'under': [1827], 'microscopic': [1828], 'guidance.': [1829], 'dissected': [1831], 'quickly': [1834], 'rinsed': [1835, 2108], 'ice-cold': [1837, 2110], 'phosphate-buffered': [1838, 2111, 2145], 'saline,': [1839], 'blotted': [1840], 'filter': [1842], 'paper,': [1843], 'weighed,': [1844], 'homogenized': [1846], '(Polytron': [1847], 'PT': [1848], '10/35,': [1849], 'Brinkmann': [1850], 'Instruments)': [1851], '1': [1853, 2622, 2687, 3768, 3790, 3842, 3998], 'ml': [1854, 1888], 'acid': [1856, 1890, 2566, 2642], 'alcohol': [1857, 1891, 2567, 2643], '(23.Davalli': [1858], 'A.M.': [1859], 'Ogawa': [1860], 'Scaglia': [1862], 'Wu': [1864, 1965], 'Y.J.': [1865, 1966], 'Hollister': [1866], 'Weir': [1870, 1969], 'G.C.': [1871, 1970], '44:': [1874], '104-111Crossref': [1875], 'homogenate': [1880], 'then': [1882, 2114, 2169, 2330], 'extracted': [1883, 2560, 2636], 'additional': [1886], '5': [1887, 1955, 2545, 2709, 2911, 2921, 2930], '48': [1893], '4': [1896, 2062, 2097, 2209, 2935], 'centrifuged': [1899], '2500': [1901], 'rpm': [1902], '30': [1904], 'min.': [1905], 'Then,': [1906], 'supernatant': [1908], 'stored': [1910], '−20': [1912], 'until': [1914], 'it': [1915], 'assayed': [1917], 'peptides': [1919], 'or': [1922, 2049, 2198, 2559, 2635, 2736, 3487, 4441], '(Bio-Rad': [1925], 'assay,': [1927], 'Bio-Rad).': [1928], 'For': [1929], 'Western': [1930], 'blot': [1931], 'detection': [1932, 2073], 'PDX-1,': [1934, 3581], 'glucokinase,': [1937], '60–100': [1938], 'freshly': [1939], 'lysed': [1943], 'buffer': [1946, 2122, 2456], 'containing': [1947, 2147, 2457], '5%': [1948, 2161], 'SDS,': [1949], '80': [1950], 'Tris/HCl,': [1952], 'pH': [1953], '6.8,': [1954], 'EDTA,': [1957], '0.5': [1959, 2438], 'phenylmethylsulfonyl': [1961], 'fluoride': [1962], '(24.Thorens': [1963], 'Leahy': [1967], 'J.L.': [1968], '1992;': [1974], '90:': [1975], '77-85Crossref': [1976], '(146)': [1979], 'sonication': [1983], 'three': [1985], '5-s': [1986], 'pulses': [1987], '20%': [1989, 3079], 'power': [1990], '(Sonifier': [1991], 'II': [1992], '250,': [1993], 'Branson': [1994], 'Ultrasonics).': [1995], 'Protein': [1996], 'concentrations': [1997], 'determined': [1999, 2493, 2569, 2744], 'Bio-Rad': [2001], 'DC': [2002], 'assay.': [2004], 'lysates': [2006], '(5–10': [2007], 'μg': [2008], 'protein/lane)': [2010], 'resolved': [2012], 'SDS-10%': [2014], 'polyacrylamide': [2015], 'gels': [2016], 'electroblotted': [2018], 'onto': [2019], 'Immobilon-P': [2021], 'membrane': [2022], '(Millipore).': [2023], 'membranes': [2025], 'incubated': [2027, 2170], 'in-house': [2030], '(from': [2031], 'W.)': [2035], 'rabbit': [2036, 2041], 'anti-mouse': [2037], 'serum': [2039, 2150, 2164, 2184, 2202, 2460, 2517, 2662], '(1:3000),': [2040], 'anti-rat': [2042, 2502, 2588], 'IgG': [2044, 2052, 2191, 2221, 2231, 2239], '(1:200,': [2045], 'Alpha': [2046], 'Diagnostic': [2047], 'International),': [2048], 'sheep': [2050, 2189], 'anti-GK': [2051], '(1:5000,': [2053], 'gift': [2054], 'Magnuson,': [2057], 'Vanderbilt': [2058], 'University)': [2059], 'overnight': [2060, 2207], '°C.': [2063, 2210], 'Appropriate': [2064], 'second': [2065, 2572], 'antibodies': [2066, 2141], 'Jackson': [2069, 2243], 'ImmunoResearch': [2070, 2166, 2244], 'Laboratories.': [2071, 2245, 2488], 'Signal': [2072], 'ECL': [2078], 'chemiluminescent': [2079], 'system': [2080], '(Amersham': [2081, 2465], 'Biosciences).': [2082], 'signals': [2084, 2214], 'each': [2086, 2323], 'autoradiographs': [2089], 'quantified': [2091, 2273, 2802], 'densitometry.': [2093], 'Densitometry': [2094], 'measurements': [2095], '6': [2099, 2283, 2907, 2917, 2970, 2976], 'separate': [2100], 'isolations': [2102], 'averaged.': [2104], 'Pancreatic': [2105], 'tissue': [2106, 3198], 'fixed': [2115], '4.0%': [2117], 'paraformaldehyde/0.1': [2118], 'm': [2119], 'sodium': [2120], 'phosphate': [2121], '1.5–2': [2124], 'room': [2127], 'temperature.': [2128], 'After': [2129, 2384, 3241], 'fixation,': [2130], '5-μm': [2131], 'cryosections': [2132, 2157], 'mounted': [2134], 'silanized': [2136], 'slides.': [2137], 'Primary': [2138], 'secondary': [2140], 'diluted': [2143], '1%': [2148, 2458], 'bovine': [2149, 2459], 'albumin': [2151], '0.1%': [2153], 'Triton': [2154], 'X-100.': [2155], 'blocked': [2159], 'donkey': [2163, 2219, 2228, 2237], '(Jackson': [2165], 'Laboratories)': [2167], 'antiserum': [2174], '(1:5000),': [2175], 'antibody': [2178], '(1:500),': [2179], 'guinea': [2180, 2199, 2500, 2510, 2586, 2649, 2655], 'pig': [2181, 2200, 2230, 2501, 2511, 2515, 2587, 2650, 2656], 'anti-bovine': [2182], '(1:500,': [2185, 2203], 'INS,': [2186, 2289], 'Linco': [2187, 2205], 'Research),': [2188, 2519], 'anti-somatostatin': [2190], '(1:2000,': [2192], 'SOM,': [2193], 'American': [2194], 'Research': [2195], 'Products,': [2196], 'Inc.)': [2197, 2581], 'anti-glucagon': [2201, 2651], 'GLU,': [2204], 'Research)': [2206], 'visualized': [2216], 'CY3-conjugated': [2218], 'anti-rabbit': [2220, 2660], '(1:1000);': [2222, 2232], 'CY2-conjugated': [2227], 'anti-guinea': [2229, 2514], 'CY5-conjugated': [2236], 'anti-sheep': [2238], '(1:1000),': [2240], 'all': [2241], 'Digital': [2246], 'images': [2247, 2301, 3832], 'samples': [2250], 'acquired': [2252], 'Zeiss': [2255], 'LSM410': [2256], 'confocal': [2257], 'laser': [2258], 'scanning': [2259], 'microscope.': [2260], 'Populations': [2261], 'α,': [2263], 'β,': [2264], 'δ': [2266, 3488], 'cells': [2267], 'integrated': [2275, 4040, 4082, 4129, 4171, 4279], 'morphometric': [2276], 'analysis.': [2277], 'Adjacent': [2278], 'sections': [2279], '3': [2281], 'mouse': [2284, 2548, 2557, 2563, 2633, 2639, 2740], 'labeled': [2287], 'double-labeled': [2291], 'GLU': [2293], 'SOM': [2295], 'above.': [2298], 'digital': [2300, 2804], 'individual': [2303], 'islets,': [2304, 3779], 'area': [2306, 2338], 'INS+,': [2308, 2341], 'GLU+,': [2309, 2342], 'SOM+cells': [2311], 'computed': [2313], 'MetaMorph': [2315], '4.6': [2316], 'software': [2317], '(Universal': [2318], 'Imaging).': [2319], 'population': [2321], 'cell': [2324], 'expressed': [2331, 2813], 'percentage': [2334], 'total': [2337], 'corresponding': [2339], 'SOM+': [2344], 'cells.': [2345, 3489], 'Mouse': [2346, 2489], 'humidified': [2354], 'temperature-controlled': [2356], 'chamber': [2357], '(37': [2358], '°C)': [2359], 'according': [2360, 2752], 'method': [2363], 'Bonnevie-Nielsen': [2365], 'al.': [2367, 3334, 3526], '(25.Bonnevie-Nielsen': [2368], 'Steffes': [2370], 'M.W.': [2371], 'Lernmark': [2372], '1981;': [2375], '30:': [2376], '424-429Crossref': [2377], 'modifications.': [2383], 'ligating': [2385], 'superior': [2387], 'mesenteric': [2388], 'artery,': [2389, 2392, 2395], 'hepatic': [2391], 'right': [2397], 'left': [2399], 'renal': [2400], 'arteries,': [2401], 'aorta': [2404], 'just': [2405], 'below': [2406], 'diaphragm,': [2408], 'celiac': [2410], 'trunk': [2411], 'through': [2414, 2425], 'catheter': [2416, 2427], 'placed': [2417, 2428], 'aorta.': [2420], 'effluents': [2422], 'collected': [2424], 'portal': [2431], 'vein.': [2432], 'maintained': [2436], 'ml/min': [2439], 'peristaltic': [2442], 'pump': [2443], '(ISM758,': [2444], 'Ismatech).': [2445], 'filtered': [2447], 'perfusate': [2448], '(0.45': [2449], 'μm)': [2450], 'consisted': [2451], 'oxygenated': [2453], 'Krebs-Ringer': [2454], 'bicarbonate': [2455], 'albumin,': [2461], '3%': [2462], 'Dextran': [2463], 'T70': [2464], 'Biosciences),': [2466], 'variable': [2469, 3563], 'concentration.': [2471], 'Arginine·HCl,': [2472], '(KIC),': [2474], 'glibenclamide': [2476, 4000, 4087], 'Sigma-Aldrich.': [2479], 'peptide': [2482, 3391, 3997], 'GLP-1-(7–36)': [2483], 'amide': [2484], 'Peninsula': [2487], 'plasma': [2490, 3090, 3136, 3141, 3272], 'heterospecies-specific': [2496, 2573], 'RIA': [2497, 2526, 2574, 2592, 2647, 2704, 2747], 'operated': [2498], 'serum,': [2504, 2512, 2652, 2657], 'rat': [2505], 'reference': [2507], 'standard,': [2508], 'goat': [2513, 2659], 'gammaglobulin': [2516, 2661], '(Linco': [2518, 2663], '125I-human': [2521], '(Diagnostic': [2523], 'Products).': [2524], 'sensitivity': [2529, 2595, 2670, 3199], '(ED90)': [2530, 2596, 2671], '7.5': [2532, 4056], 'pg': [2533, 2540, 2674, 2710, 2717], 'insulin/ml,': [2535, 2601], 'which': [2536, 2602, 2677, 2713, 3267, 3629, 4419], 'converts': [2537, 2603, 2678, 2714], '150': [2539], 'insulin/ml': [2542, 2608], 'μl': [2546, 2612, 2623, 2688, 2723], 'plasma/assay': [2549], 'tube.': [2550, 2627], 'released': [2552, 2629, 3694, 4396], 'antibody-coated': [2577], 'tubes': [2578], '(INC': [2579], 'Pharmaceuticals,': [2580], 'place': [2583], 'serum.': [2590], '0.25': [2598, 2605], 'ng': [2599, 2606, 2681, 4057, 4069, 4099, 4111, 4146, 4158, 4187, 4200, 4289, 4299, 4324, 4334, 4359, 4369], '100': [2611], 'perfusate/assay': [2615, 2725], 'tube': [2616], '25': [2618, 2716], 'ng/ml': [2619], 'extract/assay': [2626, 2690], 'Glucagon': [2628], 'measured': [2645, 3100, 3826, 3957], '125I-glucagon,': [2653], 'Research).': [2664], 'An': [2665], 'equilibrium': [2666], 'assay': [2667], '15': [2673], 'glucagon/ml,': [2676, 2712], '1.5': [2680], 'glucagon/ml': [2683, 2719], 'tube,': [2691, 2726], 'content.': [2698], 'A': [2699, 3038], 'more': [2700], 'sensitive': [2701], 'disequilibrium': [2702], 'ED90': [2707], 'employed': [2728], 'measure': [2730], 'perfusate.': [2734], 'IAPP': [2735, 3380], 'amylin': [2737], 'extracts': [2742], 'kit': [2748], 'Phoenix': [2750], 'Pharmaceuticals': [2751], "manufacturer's": [2755], 'instructions.': [2756], 'imaging': [2758], '(TPEM)': [2765], 'previously': [2768], '(26.Piston': [2769], 'D.W.': [2770], 'Knobel': [2771], 'S.M.': [2772], 'Postic': [2773], 'Shelton': [2775], 'K.D.': [2776], '274:': [2783], '1000-1004Abstract': [2784], '(58)': [2792], 'autoflourescence': [2800], 'image': [2805, 3906, 4217, 4383], 'NIH': [2808], 'Image': [2809, 3902, 4213, 4379], '1.61.': [2810], 'Results': [2811], 'mean': [2815], '±': [2816, 2906, 2916, 2925, 2934, 2965, 2975, 2988, 2996, 3401, 3403, 3405, 3407, 3409, 3421, 3423, 3425, 3427, 3429, 3723, 3729, 4055, 4067, 4097, 4109, 4144, 4156, 4185, 4198, 4287, 4297, 4322, 4332, 4357, 4367], 'S.E.': [2817], 'unpaired': [2819], "Student's": [2820], 't': [2821], 'test': [2822], 'comparisons': [2826], 'mice,': [2834, 3023, 3616, 4304, 4339, 4374], 'exception': [2837], 'gradient': [2842, 3654, 3713], 'where': [2843], 'data': [2844, 3069, 3117, 3181], 'compared': [2846, 3020, 3444, 3459, 3501, 3612, 3813, 3886], 'repeated': [2848], 'measures': [2849], 'two-way': [2852], 'variance.': [2855], 'Differences': [2856], 'considered': [2858], 'significant': [2861], 'p': [2863, 2981, 3001, 3441, 3456, 3883, 4078, 4120, 4167, 4209, 4305, 4340, 4375], '<': [2864, 3002, 3442, 3457, 3884], '0.05.': [2865], 'Mice': [2866], 'inactivated': [2869], 'clearance': [2876], 'testing': [2880], '(Fig.': [2881, 3109, 3476, 3506, 3597, 3655, 3771, 3795, 3820], '1).': [2882], 'At': [2883], '8': [2884], 'weeks': [2885], 'age,': [2887], 'levels': [2892, 2948, 3092, 3096, 3143, 3274], 'different': [2895, 3897, 4274], 'littermates': [2902, 3104, 4021, 4251, 4407], '(PDX-1+/+': [2903, 2962, 3835], 'males': [2904, 2914, 2963, 2973, 3061, 3891, 4268], '62': [2905], 'mg/dl,': [2908, 2918, 2927, 2936, 2967, 2977], 'n': [2909, 2919, 2928, 2937, 2968, 2978, 2990, 2998, 4244, 4254], '=': [2910, 2920, 2929, 2938, 2969, 2979, 2982, 2991, 2999, 3411, 3413, 3415, 3417, 3419, 3431, 3433, 3435, 3437, 3439, 3870, 3875, 4064, 4076, 4079, 4106, 4118, 4121, 4151, 4165, 4168, 4194, 4207, 4210, 4245, 4255, 4306, 4341, 4376], 'versus': [2912, 2971, 3041, 4154, 4196, 4295, 4330, 4365], '73': [2915], 'PDX-1+/+females': [2923], '50': [2924, 3863], '7': [2926], 'versusPDX-1+/−': [2931], 'females': [2932, 2986, 2994, 3063, 3082, 3893, 4270], '63': [2933, 2987], '9).': [2939], 'older': [2941], '(16–25': [2943], 'weeks),': [2944], 'increased,': [2949], 'they': [2951], 'still': [2953], 'statistically': [2954], 'insignificant': [2955], 'male': [2958, 4028], 'group': [2959, 4031], '78': [2964], '9': [2966], '92': [2974], '13,': [2980], '0.22;': [2983], '7,': [2989], '4versus': [2992], '81': [2995], '4,': [2997], '10,': [3000], '0.05).': [3003], 'following': [3005], 'administration,': [3007], 'pronounced': [3012], 'prolonged': [3014], 'rise': [3015], 'this': [3025, 3780], 'abnormality': [3026], 'became': [3027], 'even': [3028], 'greater': [3029], 'aged': [3032], '(8-week-old': [3033], 'Fig.': [3036, 3045], '1,': [3037, 3046], 'D': [3040], '16–25-week-old': [3042], 'B': [3047], 'E).': [3049], 'There': [3050], 'gender-related': [3053], 'difference': [3054], 'clearance,': [3058], 'tolerance.': [3067], 'IPGTT': [3071], 'showed': [3072, 3759], 'PDX-1+/−males': [3076], '(7/23)': [3077], '(4/20)': [3083], 'tolerance;': [3087], 'however,': [3088], 'those': [3099], '1C).': [3110], 'finding': [3112], 'somewhat': [3114, 3562], 'human': [3119], 'subjects': [3120], '(D76N': [3130], 'variant)': [3131], 'levels,': [3138], 'load': [3148], 'lower': [3151, 3271], '(16.Hani': [3152], 'More': [3179], 'study': [3184], 'MODY4': [3186, 3210], 'patients': [3187], '(heterozygous': [3188], 'mutation)': [3192], 'suggests': [3194, 3320], 'increased': [3196, 3373, 3788], 'peripheral': [3197], 'mechanism': [3204, 3265], 'maintaining': [3206], 'homeostasis': [3208], 'phenotyped': [3245], 'IPGTT,': [3247], 'included': [3256], 'below.': [3261], 'investigate': [3263], 'than': [3275, 4401], 'littermates,': [3279], 'regulated': [3292], 'vitro': [3294], 'PDX-1.': [3296], 'As': [3297], 'shown': [3298], 'Table': [3300], 'I,': [3301], 'decrease': [3303, 3319], 'caused': [3312], 'insulin.': [3316], 'Rather,': [3317], 'inability': [3322], 'heterozygotes': [3326, 3801, 4014, 4241], 'respond': [3328], 'extracellular': [3330], '(8.Ahlgren': [3335, 3527], 'reported': [3355, 3547], 'contrast,': [3366], '29%,': [3375], '32%': [3384], '(Table': [3388], 'I).Table': [3389], 'IPancreatic': [3390], 'contentAgeBody': [3392], 'wt.Pancreatic': [3393], 'wt.Insulin': [3394], 'Content/Pancreatic': [3395, 3397, 3399], 'ProteinGlucagon': [3396], 'ProteinIAPP': [3398], 'Proteinwkgmgμg/mgng/mgng/mgPDX-125–4036.1': [3400], '1.8220': [3402], '1117.5': [3404], '1.6365': [3406], '31411': [3408], '46+/+(n': [3410], '14)(n': [3412, 3414], '9)(n': [3416], '13)(n': [3418], '14)PDX-125–4035.8': [3420], '2.2199': [3422], '1518.0': [3424], '3.5470': [3426], '40a278': [3428], '33a+/−(n': [3430], '16)(n': [3432, 3434], '12)(n': [3436], '10)(n': [3438], '15)a': [3440], '0.05': [3443, 3458], '+/+': [3447, 3462], 'Open': [3449], 'table': [3450], 'new': [3453], 'tab': [3454], 'Immunohistochemical': [3464], 'evaluation': [3465], '16–18-week-old': [3469], 'revealed': [3472], 'morphology': [3475], '2,': [3477, 3507], 'a–f)': [3478], 'ratio': [3482], 'β': [3484, 3639], 'α': [3486], 'quite': [3499], 'dramatically': [3500], 'c': [3508], 'd).': [3510], 'Similar': [3511, 4386], 'changes': [3512, 3672], 'seen': [3517], '7-week-old': [3519], '(data': [3521], 'shown).': [3523], 'decreases': [3549], 'islet,': [3567], 'only': [3575], 'reduced.': [3577], 'GK': [3584, 3618], 'evaluated': [3593], 'immunoblot': [3595], '2g).': [3598], 'Expression': [3599], 'relatively': [3621], 'unchanged.': [3622], 'define': [3624], 'molecular': [3626, 3736, 3912], 'mechanisms': [3627], 'deficiency': [3631], 'alters': [3632], '(GSIS)': [3636], 'cells,': [3640], 'challenged': [3649], 'linear': [3652], '3)': [3656, 4152, 4195], 'technique.': [3663], 'technique': [3665], 'uses': [3666], 'native': [3668], 'vasculature': [3669], 'deliver': [3671], 'avoids': [3680], 'need': [3682], 'enzymatic': [3684], 'isolation.': [3688], 'amount': [3691], 'after': [3695, 3849], 'stimulation': [3697, 3985], 'animals,': [3702], '(12.0': [3722], '1.3': [3724], 'mm)': [3725, 3731], '(8.0': [3728], '0.4': [3730], 'examine': [3735, 3910], 'GSIS': [3740], 'pathway,': [3741], 'glucose-induced': [3744], 'TPEM.': [3751, 3828], 'very': [3761], 'uniform': [3762], 'autofluorescent': [3763, 3831], 'signal': [3764, 3781], 'exposure': [3766], '4a).': [3772], 'case': [3775], 'greatly': [3783], 'enhanced': [3784], '4b).': [3796], '4c).Figure': [3821], '4NAD(P)H': [3822], 'a,': [3829], '(left)': [3837], 'PDX-1+/−islet': [3839], '(right))': [3840], 'b,': [3845], 'same': [3846], '5-min': [3850], 'challenge': [3851], 'bar': [3857], 'bottom': [3860], 'corresponds': [3861], 'μm.': [3864], 'c,': [3865], '(n': [3869, 3874, 4063, 4075, 4105, 4117, 4164, 4193, 4206], '35)': [3871, 3876], '(**,': [3882], '0.01': [3885], 'controls).': [3888], 'Data': [3889, 4266], 'combined.View': [3900], 'Large': [3901, 4212, 4378], 'Figure': [3903, 4214, 4380], 'ViewerDownload': [3904, 4215, 4381], 'Hi-res': [3905, 4216, 4382], 'Download': [3907, 4218, 4384], '(PPT)': [3908, 4385], 'cytoplasmic': [3919], 'metabolism': [3922], 'glucose,': [3924, 4262], 'closure': [3925], 'KATP+': [3927], 'channels,': [3928, 3933], 'opening': [3929], 'voltage-dependent': [3931], 'calcium': [3932], 'Ca2+influx,': [3934], 'Ca2+': [3937, 3947], 'stores': [3940], '(ryanodine': [3941], 'receptor': [3942], 'inositol': [3944], '1,4,5-trisphosphate': [3945], 'receptor-mediated': [3946], 'release),': [3948], 'exocytosis': [3950], 'granules,': [3955], 'non-glucose': [3965], 'secretagogues': [3966], 'pancreas.': [3972], 'Changes': [3973], 'output': [3976], 'respect': [3978], 'time': [3981], 'course': [3982], 'plotted': [3987], 'Figs.5A,6,': [3989], '7.Figure': [3991], '6Insulin': [3992], 'situ.': [4006, 4233], '(closed': [4015, 4242], 'circles)': [4016, 4023], '(open': [4022, 4252], 'analyzed': [4025, 4258], 'female': [4030], 'A,': [4034], 'males.': [4038], 'GLP-1': [4045, 4134], 'presence': [4048, 4090, 4137, 4178, 4316, 4351], '5.6': [4050, 4092, 4139, 4180, 4288], '32.3': [4054], '4)': [4065, 4107], 'versus68.5': [4066], '11.1': [4068], '5),': [4077, 4119], '0.038.': [4080], '26.1': [4096], '3.5': [4098], 'versus30.7': [4108], '6.7': [4110], '0.593.': [4122], 'B,': [4123], 'females.': [4127], '4.9': [4143], '1.8': [4145], 'PDX-1+/+(n': [4150], '13.3': [4155], '2.5': [4157], '3),': [4166, 4208], '0.052.': [4169], 'nmglibenclamide': [4175], '14.8': [4184], '3.2': [4186], '15.7': [4197], '2.1': [4199], '0.831.View': [4211], '(PPT)Figure': [4219], '7Insulin': [4220], 'potassium': [4226], 'chloride': [4227], 'circles,': [4243, 4253], '5)': [4246], '8)': [4256], 'KIC,': [4263, 4449], 'KCl.': [4265, 4451], 'combined.': [4277], '55.4': [4286], '29.0': [4296], '2.9': [4298], '0.005.': [4307], 'Integrated': [4308, 4343], 'KIC': [4313], '2.8': [4318, 4353], 'mmglucose': [4319, 4354, 4412], '120': [4321], '19': [4323], '46.8': [4331], '8.2': [4333], '0.016.': [4342], '134': [4356], '45.4': [4366], '9.1': [4368], '0.006.View': [4377], 'vivo': [4389], 'results,': [4390], '(Figs.': [4413], '5A': [4414], '7).': [4416], 'localize': [4418], 'steps': [4420], 'pathway': [4425], 'PDX-1-regulated,': [4427], 'secretagogues,': [4436], 'either': [4437], 'coupled': [4438], 'acting': [4442], 'independently,': [4443], 'arginine,': [4446], 'GLP-1,': [4447], 'glibenclamide,': [4448], 'magnitude': [4453]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026145411', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-12-08T18:46:00.200103', 'created_date': '2016-06-24'}