Publication Information

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'https://openalex.org/W3024663266', 'https://openalex.org/W3020994670', 'https://openalex.org/W2735536323', 'https://openalex.org/W2332296840', 'https://openalex.org/W2079567903', 'https://openalex.org/W2062835892', 'https://openalex.org/W2025332479', 'https://openalex.org/W1992973683', 'https://openalex.org/W1573780196'], 'abstract_inverted_index': {'Airway': [0, 151], 'epithelial': [1, 57, 139, 152, 208, 290, 347, 350, 373, 376, 516, 632, 714, 724, 764, 1820, 1854, 1866, 1893, 1900, 1912, 2038, 2141, 2198, 2246, 3719, 3736, 3770, 3944, 4104, 4130, 4138, 4145, 4207, 4303], 'cells': [2, 140, 153, 291, 305, 517, 520, 765, 1855, 1867, 2039, 2072, 2142, 2180, 2247, 2275, 2305, 2532, 2551, 2555, 2589, 2991, 3031, 3043, 3428, 3445, 3534, 3555, 3573, 3591, 3634, 3688, 3737, 3771, 3811, 3864, 3934, 3945, 3968, 4048, 4131, 4166, 4208, 4229, 4250, 4313], 'are': [3, 154, 522, 780, 810, 3297, 3899], 'unresponsive': [4, 155], 'to': [5, 26, 55, 104, 120, 146, 156, 177, 206, 255, 271, 297, 306, 308, 755, 785, 807, 823, 1074, 1202, 1218, 1221, 1233, 1263, 1455, 1852, 1870, 1954, 2003, 2301, 2552, 2683, 2699, 2875, 2884, 2985, 3171, 3185, 3207, 3301, 3383, 3421, 3537, 3655, 3689, 3740, 3884, 3938, 4005, 4091, 4270], 'endotoxin': [6, 157, 1429, 1443, 1456, 1604], '(lipopolysaccharide': [7, 158], '(LPS))': [8, 159], 'exposure': [9, 124, 160, 275, 818, 1272, 1454, 1605, 1674, 1774, 2980, 3739, 3931], 'under': [10, 161], 'normal': [11, 162, 762, 2449, 3964], 'conditions.': [12, 163], 'This': [13, 49, 164, 200, 1733, 2488, 3822, 3919, 4274], 'study': [14, 165, 691, 1163, 1633, 1840, 2299, 2489], 'demonstrates': [15, 166, 3793, 4124], 'that': [16, 59, 114, 167, 210, 265, 519, 521, 629, 656, 711, 758, 792, 802, 819, 1273, 1366, 1452, 1670, 1759, 1775, 1793, 1908, 3794, 3923, 4070, 4082], 'respiratory': [17, 168, 919, 1009], 'syncytial': [18, 169, 331, 357], 'virus': [19, 170, 993, 2122], '(RSV)': [20, 171], 'infection': [21, 94, 116, 172, 245, 267, 779, 832, 911, 1268, 1286, 1829, 1910, 3639, 4043, 4190, 4241], 'results': [22, 33, 70, 173, 184, 221, 912], 'in': [23, 34, 71, 174, 185, 222, 514, 523, 630, 636, 640, 658, 768, 913, 966, 979, 1161, 1198, 1257, 1278, 1444, 1663, 1684, 1748, 1788, 1888, 1981, 2053, 2061, 2195, 2288, 2312, 2334, 2595, 2715, 2920, 3108, 3187, 3195, 3429, 3540, 3594, 3602, 3712, 3844, 3855, 3894, 3907, 3911, 3932, 4086, 4126, 4133, 4142, 4169, 4195, 4201, 4227, 4235], 'increased': [24, 35, 45, 68, 79, 135, 175, 186, 196, 219, 230, 286, 1244, 1848, 1883], 'sensitivity': [25, 176], 'this': [27, 178, 1760, 1809, 3395], 'environmental': [28, 123, 179, 274, 531, 667, 790, 1239, 1271, 1807, 1913], 'exposure.': [29, 180, 3694], 'Infection': [30, 181], 'with': [31, 107, 182, 258, 526, 661, 671, 770, 833, 1280, 2065, 2078, 2202, 2296, 2318, 2332, 2451, 2543, 2837, 2877, 2917, 2924, 2935, 2950, 2957, 2979, 2994, 2996, 3034, 3055, 3095, 3116, 3436, 3448, 3467, 3471, 3478, 3571, 3583, 3644, 3650, 3707, 3775, 3916, 4051, 4110, 4253, 4316, 4328], 'RSV': [32, 93, 115, 183, 244, 266, 774, 778, 834, 910, 1210, 1212, 1267, 1285, 1828, 1909, 2333, 2995, 3035, 3550, 3638, 4042, 4052, 4071, 4111, 4148, 4159, 4173, 4189, 4256, 4319], 'expression': [36, 128, 187, 279, 313, 730, 1260, 1832, 1844, 1919, 4150, 4162, 4212], 'of': [37, 64, 132, 188, 215, 283, 304, 314, 317, 535, 674, 717, 722, 731, 736, 827, 839, 998, 1207, 1225, 1230, 1246, 1255, 1371, 1375, 1428, 1442, 1447, 1462, 1602, 1688, 1736, 1741, 1764, 1767, 1791, 1799, 1817, 1827, 1838, 1850, 1864, 1891, 1922, 2083, 2134, 2150, 2290, 2342, 2503, 2505, 2510, 2517, 2540, 2579, 2598, 2674, 2742, 2749, 2832, 2890, 2941, 2982, 3001, 3121, 3124, 3161, 3166, 3203, 3210, 3235, 3246, 3318, 3394, 3404, 3426, 3455, 3503, 3686, 3718, 3806, 3835, 3838, 3841, 3852, 3881, 3887, 3926, 3941, 3950, 3963, 3977, 4002, 4041, 4151, 4158, 4163, 4172, 4198, 4205, 4213, 4263, 4278, 4301], 'Toll-like': [38, 189, 322], 'receptor': [39, 190, 1259], '(TLR)': [40, 191], '4': [41, 192, 2639, 2724, 3093], 'mRNA,': [42, 193, 4244], 'protein,': [43, 194, 1033, 1037, 4245], 'and': [44, 87, 129, 141, 195, 238, 280, 292, 529, 643, 665, 694, 733, 772, 777, 789, 797, 917, 983, 994, 1018, 1048, 1160, 1238, 1249, 1266, 1283, 1380, 1805, 1823, 1833, 1845, 1861, 1878, 1920, 1935, 1964, 1974, 1984, 1994, 2015, 2034, 2107, 2280, 2286, 2324, 2461, 2484, 2574, 2619, 2636, 2644, 2678, 2687, 2709, 2726, 2850, 2856, 2863, 2932, 2952, 2988, 2997, 3013, 3062, 3072, 3163, 3237, 3243, 3251, 3294, 3332, 3359, 3408, 3416, 3441, 3469, 3491, 3553, 3585, 3600, 3640, 3648, 3668, 3701, 3735, 3745, 3768, 3786, 3798, 3867, 3966, 3971, 3986, 4014, 4035, 4056, 4060, 4067, 4075, 4099, 4101, 4115, 4141, 4182, 4221, 4230, 4246, 4309, 4333], 'TLR4': [46, 69, 105, 197, 220, 256, 634, 718, 732, 1077, 1196, 1742, 1831, 1843, 1877, 1955, 3162, 3628, 3836, 3853, 3868, 3882, 3908, 3951, 3985, 4003, 4033, 4045, 4073, 4087, 4116, 4152, 4199, 4214, 4237, 4243, 4271], 'membrane': [47, 130, 198, 281, 1834, 1846, 2711, 2729, 4203, 4247], 'localization.': [48, 199, 1835, 4248], 'permits': [50, 201], 'significantly': [51, 202], 'enhanced': [52, 203], 'LPS': [53, 142, 204, 293, 737, 1288, 1673, 1737, 1765, 1787, 1815, 1851, 1884, 1924, 1945, 3002, 3439, 3450, 3564, 3693, 3762, 3776, 3930], 'binding': [54, 205, 1849, 3078, 3086, 3440], 'the': [56, 65, 144, 207, 216, 295, 536, 641, 647, 672, 712, 812, 824, 836, 909, 967, 974, 999, 1004, 1008, 1029, 1034, 1208, 1222, 1228, 1247, 1253, 1440, 1445, 1739, 1789, 1814, 1825, 1839, 1862, 1923, 1982, 2132, 2493, 2501, 2518, 2529, 2549, 2588, 2645, 2672, 2685, 2689, 2701, 2710, 2740, 2885, 2891, 2895, 2936, 2999, 3022, 3122, 3130, 3141, 3323, 3346, 3356, 3360, 3370, 3374, 3390, 3444, 3452, 3501, 3554, 3572, 3575, 3633, 3684, 3818, 3839, 3850, 3879, 3888, 3895, 3921, 3924, 3961, 4000, 4006, 4039, 4083, 4156, 4170, 4196, 4202, 4232], 'monolayer': [58, 209], 'is': [60, 211, 635, 653, 657, 719, 759, 766, 829, 905, 963, 972, 987, 995, 1011, 1287, 1368, 1433, 1436, 3526, 3710, 3824, 3902, 4276, 4283], 'blocked': [61, 212, 2916], 'by': [62, 78, 126, 213, 229, 277, 692, 761, 782, 1012, 1164, 1634, 2131, 2283, 2492, 2515, 2538, 2586, 2650, 2664, 2733, 3019, 3344, 3369, 3389, 3399, 3493, 3588, 3615, 3631, 3635, 3675, 3726, 3989, 3998, 4119], 'disruption': [63, 214], 'Golgi.': [66, 217], 'The': [67, 134, 218, 285, 302, 650, 800, 903, 1068, 1243, 1426, 1836, 1873, 2098, 2121, 2179, 2628, 2703, 2912, 2944, 3008, 3042, 3076, 3110, 3180, 3336, 3411, 3590, 3782, 4017, 4323], 'an': [72, 108, 223, 259, 679, 686, 988, 1204, 1264, 1678, 1916, 2544, 2666, 2679, 3101, 3559, 3903, 4143, 4268, 4329], 'LPS-induced': [73, 224, 3842], 'inflammatory': [74, 225, 795], 'response': [75, 226], 'as': [76, 227, 1261, 1677, 1743, 1880, 1882, 2154, 2251, 2337, 2352, 2707, 2753, 3081, 3193, 3256, 3298, 3355, 3715, 3914, 4285, 4295], 'demonstrated': [77, 228, 760, 1073, 4231], 'mitogen-activated': [80, 231], 'protein': [81, 232, 1053, 1070, 2583, 2660, 2833, 2892, 3085, 4076, 4178], '(MAP)': [82, 233], 'kinase': [83, 234], 'activity,': [84, 235], 'IL-8': [85, 236, 1983, 3014, 3691, 3709, 3787, 3843, 3927], 'production,': [86, 237], 'tumor': [88, 98, 239, 249], 'necrosis': [89, 99, 240, 250, 336, 362], 'factor': [90, 100, 241, 251], 'α': [91, 101, 242, 252], 'production.': [92, 243], 'also': [95, 246, 720, 1757, 4216], 'allowed': [96, 247], 'for': [97, 248, 811, 915, 973, 1025, 1598, 1680, 1786, 1979, 2118, 2298, 2339, 2495, 2592, 2633, 2641, 2656, 2671, 2696, 2739, 2746, 2868, 2906, 2928, 2954, 3005, 3036, 3064, 3290, 3327, 3339, 3348, 3363, 3373, 3414, 3458, 3519, 3528, 3558, 3574, 3597, 3611, 3627, 3779, 3984, 4010, 4053, 4058, 4112, 4174, 4187, 4257, 4320, 4335], 'production': [102, 253, 3788], 'subsequent': [103, 122, 254, 273, 825, 1235, 1460], 'cross-linking': [106, 257], 'immobilized': [109, 260], 'antibody.': [110, 261], 'These': [111, 262, 669, 1027, 1780], 'data': [112, 263, 3252], 'suggest': [113, 264, 628, 1451, 1782, 1907], 'sensitizes': [117, 268, 1232], 'airway': [118, 138, 149, 269, 289, 300, 346, 372, 651, 723, 763, 4129], 'epithelium': [119, 270, 652, 2149], 'a': [121, 272, 315, 734, 804, 830, 996, 1040, 1050, 1162, 1369, 1599, 1685, 1753, 1783, 1797, 1818, 1857, 1889, 1903, 2452, 2474, 2558, 2734, 2859, 2878, 2902, 2968, 3065, 3188, 3196, 3495, 3645, 3651, 3696, 3716, 3939, 4134, 4192, 4222], '(LPS)': [125, 276], 'altered': [127, 278, 767], 'localization': [131, 282], 'TLR4.': [133, 284, 1755, 4188], 'interaction': [136, 287], 'between': [137, 288, 2482, 3993], 'has': [143, 294, 820, 1071, 1213], 'potential': [145, 296], 'profoundly': [147, 298], 'alter': [148, 299], 'inflammation.': [150, 301, 3721], 'ability': [303, 3685], 'respond': [307], 'microbial': [309], 'motifs': [310], 'depends': [311], 'on': [312, 646, 1430, 1796, 1830, 1918, 2183, 2293, 2590, 2894, 2909, 3663, 4044, 4160], 'family': [316, 1000], 'Type': [318, 2044], 'I': [319, 3227], 'transmembrane': [320], 'receptors,': [321], 'receptors': [323], '(TLRs)': [324], '1The': [325], 'abbreviations': [326, 352], 'used': [327, 353, 2237, 3711], 'are:': [328, 354], 'TLRToll-like': [329, 355], 'receptorRSVrespiratory': [330, 356], 'virusLPSlipopolysaccharideMAPmitogen-activated': [332, 358], 'proteinERKextracellular': [333, 359], 'signal-regulated': [334, 360], 'kinaseTNFtumor': [335, 361], 'factorELISAenzyme-linked': [337, 363], 'immunosorbent': [338, 364], 'assayPBSphosphate-buffered': [339, 365], 'salineHPRThuman': [340, 366], 'hypoxanthine': [341, 367], 'phosphoribosyltransferaseFACSfluorescence-activated': [342, 368], 'cell': [343, 369, 715, 1006, 1013, 1821, 2199, 2469, 2479, 2582, 3720, 3897, 3994, 4062, 4096, 4105, 4224, 4265], 'sorterRTreverse': [344, 370], 'transcriptaseHAEhuman': [345, 371], 'cellshTBEhuman': [348, 374], 'tracheobronchial': [349, 375, 2245], 'cells.1The': [351], 'cells.': [377, 725, 1872, 1901, 3862, 3918, 4016], '(1Medzhitov': [378], 'R.': [379, 395, 412, 425, 438, 579, 1081, 1171, 1342, 1406, 1472, 1495, 1509, 1539, 1574, 1713, 2436], 'Biron': [380], 'C.A.': [381, 410, 1647], 'Curr.': [382, 396, 475, 1560, 1579], 'Opin.': [383, 476, 1561, 1580], 'Immunol.': [384, 399, 415, 428, 503, 563, 615, 701, 744, 1151, 1564, 1583, 2390, 2442, 2793], '2003;': [385, 504, 564, 702, 745, 2227, 2794, 2817, 3752], '15:': [386], '2-4Crossref': [387], 'Scopus': [388, 404, 420, 433, 453, 469, 482, 508, 568, 598, 620, 706, 749, 854, 884, 947, 1102, 1124, 1156, 1192, 1315, 1358, 1422, 1484, 1502, 1550, 1569, 1588, 1627, 1657, 1729, 2231, 2270, 2373, 2395, 2425, 2780, 2798, 2826, 3285, 3756], '(30)': [389], 'Google': [390, 406, 422, 435, 455, 471, 484, 495, 510, 570, 600, 622, 708, 751, 856, 886, 901, 949, 961, 1066, 1104, 1126, 1158, 1194, 1317, 1360, 1424, 1486, 1504, 1552, 1571, 1590, 1629, 1659, 1731, 2177, 2233, 2272, 2375, 2397, 2427, 2446, 2782, 2800, 2828, 3287, 3758], 'Scholar,': [391, 407, 423, 436, 456, 472, 485, 496, 571, 601, 857, 887, 950, 1105, 1127, 1318, 1487, 1505, 1553, 1572, 2376, 2398, 2428, 2783, 2801], '2Barton': [392], 'G.M.': [393], 'Medzhitov': [394, 411], 'Top.': [397], 'Microbiol.': [398, 443, 477], '2002;': [400, 416, 589, 1098, 1188, 1354, 1418, 1498, 1546, 1565, 1584, 1623, 1653, 1725, 2174, 2416, 2771, 3276], '270:': [401], '81-92Crossref': [402], 'PubMed': [403, 419, 432, 452, 468, 481, 494, 507, 567, 597, 619, 705, 748, 853, 883, 900, 946, 1065, 1101, 1123, 1155, 1191, 1314, 1357, 1421, 1483, 1501, 1549, 1568, 1587, 1626, 1656, 1728, 2230, 2269, 2372, 2394, 2424, 2779, 2797, 2825, 3284, 3755], '(249)': [405], '3Janeway': [408], 'Jr.,': [409, 440], 'Annu.': [413], 'Rev.': [414, 427, 502, 1545], '20:': [417], '197-216Crossref': [418], '(6060)': [421], '4Medzhitov': [424], 'Nat.': [426], '2001;': [429, 491, 616, 1120, 1480, 2261, 2391], '1:': [430, 1153], '135-145Crossref': [431], '(3194)': [434], '5Medzhitov': [437], 'Janeway': [439], 'C.': [441, 1320, 1384, 1476, 1489, 1513, 1515, 1691], 'Trends': [442], '2000;': [444, 465, 478, 1152], '8:': [445], '452-456Abstract': [446], 'Full': [447, 449, 592, 594, 848, 850, 878, 880, 895, 897, 941, 943, 1309, 1311, 2264, 2266, 2367, 2369, 2419, 2421, 2774, 2776, 2820, 2822, 3279, 3281], 'Text': [448, 450, 593, 595, 849, 851, 879, 881, 896, 898, 942, 944, 1310, 1312, 2265, 2267, 2368, 2370, 2420, 2422, 2775, 2777, 2821, 2823, 3280, 3282], 'PDF': [451, 596, 852, 882, 899, 945, 1313, 2268, 2371, 2423, 2778, 2824, 3283], '(551)': [454], '6Means': [457], 'T.K.': [458], 'Golenbock': [459, 1144], 'D.T.': [460, 1145], 'Fenton': [461], 'M.J.': [462, 2170], 'Life': [463], 'Sci.': [464], '68:': [466], '241-258Crossref': [467], '(121)': [470, 2781], '7Beutler': [473], 'B.': [474, 487, 498, 557, 583, 1474, 1511], '3:': [479, 505, 1499, 1547], '23-28Crossref': [480], '(202)': [483], '8Beutler': [486], 'Biochem.': [488], 'Soc.': [489], 'Trans.': [490], '29:': [492], '853-859Crossref': [493], '9Beutler': [497], 'Rietschel': [499], 'E.T.': [500, 575, 611], 'Nat': [501, 1150], '169-176Crossref': [506], '(1027)': [509], 'Scholar).': [511, 623, 902, 1067, 1361, 1425, 1630, 1732, 2178, 2234, 2273, 2447, 2829, 3288, 3759], 'Recent': [512], 'evidence': [513, 1597], 'intestinal': [515, 631, 713], 'suggests': [518, 710, 1252, 3920], 'constant': [524, 659], 'contact': [525, 660], 'pathogenic': [527], 'microbes': [528], 'other': [530, 666, 918, 1593, 1806, 1892, 4324], 'exposures': [532, 791], 'express': [533], 'some': [534], 'TLRs': [537], 'at': [538, 2073, 2110, 2500, 2638, 2652, 2693, 2723, 2865, 2939, 3039, 3092, 3156, 3451, 3461, 3500, 3605, 3953], 'very': [539, 980, 3947], 'low': [540, 637, 1671, 1761], 'levels': [541, 3870, 3886, 3893, 3910], '(10Melmed': [542], 'G.': [543, 2434], 'Thomas': [544, 576, 608], 'L.S.': [545, 577, 609, 2438, 2787, 2805], 'Lee': [546], 'N.': [547, 1090, 1180, 1350, 1414, 1721, 3748], 'Tesfay': [548], 'S.Y.': [549], 'Lukasek': [550], 'K.': [551, 1649], 'Michelsen': [552], 'K.S.': [553], 'Zhou': [554, 580], 'Y.': [555, 581, 697, 740], 'Hu': [556, 582], 'Arditi': [558, 584, 612], 'M.': [559, 585, 613, 867, 930, 1298, 1328, 1392, 1519, 1525, 1699, 2213, 2219, 2221], 'Abreu': [560], 'M.T.': [561, 573, 603], 'J.': [562, 586, 614, 700, 743, 843, 890, 955, 1060, 1095, 1118, 1185, 1322, 1352, 1386, 1416, 1521, 1618, 1650, 1693, 1723, 2168, 2209, 2225, 2258, 2361, 2389, 2413, 2441, 2768, 2792, 2814, 3273, 3750], '170:': [565, 703, 746], '1406-1415Crossref': [566], '(368)': [569], '11Abreu': [572], 'Arnold': [574, 610], 'Gonsky': [578], 'Biol.': [587, 1622, 2173, 2259, 2362, 2414, 2769, 2815, 3274], 'Chem.': [588, 2260, 2363, 2415, 2770, 2816, 3275], '277:': [590, 2417, 2772, 3277], '20431-20437Abstract': [591], '(313)': [599], '12Abreu': [602], 'Vora': [604], 'P.': [605, 2211], 'Faure': [606], 'E.': [607, 1349, 1413, 1468, 1542, 1720], '167:': [617], '1609-1616Crossref': [618], '(592)': [621], 'More': [624], 'particularly,': [625], 'these': [626, 1665, 1905, 3028, 3713], 'studies': [627, 1363, 1450, 1906, 3714], 'cells,': [633, 2534, 2536, 3729, 3733, 3846, 4093, 4306], 'abundance,': [638, 3381, 3386], 'localized': [639], 'Golgi,': [642], 'not': [644, 683, 1214, 1746, 3825, 4089], 'present': [645, 4200], 'plasma': [648], 'membrane.': [649], 'another': [654, 2727], 'region': [655], 'multiple': [662], 'pathogen-related': [663], 'antigens': [664, 757], 'agents.': [668], 'exposures,': [670], 'exception': [673], 'significant': [675, 4193], 'pathogen': [676], 'load': [677, 4332], 'or': [678, 1031, 1045, 2458, 2745, 3015, 3059, 3100, 3545, 3657], 'immunosuppressed': [680, 984], 'host,': [681], 'do': [682], 'normally': [684], 'elicit': [685], 'immunological': [687], 'response.': [688, 1211], 'A': [689, 1631, 2113, 3523, 4066], 'recent': [690, 1632], 'Tsutsumi-Ishii': [693], 'Nagaoka': [695, 698, 741], '(13Tsutsumi-Ishii': [696, 739], 'I.': [699, 742, 1531, 1645], '4226-4236Crossref': [704, 747], '(156)': [707, 750, 2396], 'Scholar)': [709, 1660], 'lack': [716, 735, 2673, 3840, 3925, 3940], 'true': [721], 'They': [726, 1668, 1756], 'found': [727, 964, 977, 1201, 3420], 'no': [728, 2242, 2456, 2462], 'surface': [729, 1014, 4161, 4236], 'responsiveness': [738, 1245, 1816, 1914], 'Scholar).The': [752], 'relative': [753, 3382], 'tolerance': [754], 'foreign': [756], 'people': [769], 'asthma': [771, 809, 828, 1231, 1265, 1282, 1432, 1463, 1689, 1792], 'after': [773, 1284, 2239, 3692, 3738, 3958], 'infection.': [775], 'Asthma': [776], 'characterized': [781], 'non-specific': [783], 'responses': [784, 796, 1240, 1683], 'both': [786, 1234, 3795, 4011], 'infectious': [787], 'agents': [788], 'include': [793, 1028], 'heightened': [794], 'hyper-responsive': [798], 'airways.': [799], 'factors': [801], 'predispose': [803, 1219], 'particular': [805, 2743], 'individual': [806], 'developing': [808, 2016], 'most': [813, 975], 'part': [814, 976], 'unclear.': [815], 'One': [816], 'early': [817, 1209, 1453, 1603], 'been': [821, 1023, 1072, 1216], 'linked': [822], 'development': [826, 1224, 1446, 1461, 1790], 'severe': [831], 'during': [835, 3817], 'first': [837, 1813, 3643], 'year': [838], 'life': [840], '(14Eigen': [841], 'H.': [842, 1344, 1408, 1715], 'Pediatr.': [844, 891], '1999;': [845, 875, 892, 938, 1306, 2364, 2443], '135:': [846, 893], '1Abstract': [847], '(115)': [855], '15Stein': [858], 'R.T.': [859, 922, 1290], 'Sherrill': [860, 923, 1291], 'D.': [861, 924, 1292, 1334, 1346, 1398, 1410, 1705, 1717, 3480], 'Morgan': [862, 925, 1293], 'W.J.': [863, 926, 1294], 'Holberg': [864, 927, 1295], 'C.J.': [865, 928, 1296, 2217], 'Halonen': [866, 929, 1297], 'Taussig': [868, 931, 1299], 'L.M.': [869, 932, 1107, 1135, 1300], 'Wright': [870, 933, 1301], 'A.L.': [871, 934, 1302], 'Martinez': [872, 935, 1303], 'F.D.': [873, 936, 1304], 'Lancet.': [874, 937, 1305], '354:': [876, 939, 1307], '541-545Abstract': [877, 940, 1308], '(1316)': [885, 948, 1316], '16Welliver': [888], 'R.C.': [889], '14-20Abstract': [894], 'correlation': [904], 'especially': [906], 'clear': [907], 'if': [908], 'hospitalization': [914], 'bronchiolitis': [916], 'complications': [920], '(15Stein': [921, 1289], '17Levy': [951], 'B.T.': [952], 'Graber': [953], 'M.A.': [954, 1609], 'Fam.': [956], 'Pract.': [957], '1997;': [958], '45:': [959], '473-481PubMed': [960], 'Scholar).RSV': [962], 'ubiquitously': [965], 'environment.': [968], 'Serious': [969], 'illness,': [970, 2460], 'however,': [971, 1438], 'only': [978, 1215], 'young': [981], 'children': [982, 1220, 1279, 1458], 'adults.': [985], 'It': [986, 3722], 'enveloped,': [989], 'non-segmented,': [990], 'negative-strand': [991], 'RNA': [992, 1051, 3126, 3132, 3144, 3152, 3168, 3972, 4059], 'member': [997], 'Paramyxoviridae.': [1001], 'Entry': [1002], 'into': [1003], 'host': [1005], '(primarily': [1007], 'epithelium)': [1010], 'fusion.': [1015], 'Eleven': [1016], 'genes': [1017, 3296], 'their': [1019], 'encoded': [1020], 'proteins': [1021, 2744, 2750, 2872, 2908, 4266], 'have': [1022, 1364, 1752], 'identified': [1024], 'RSV.': [1026, 3437], 'F': [1030, 1069], 'fusion': [1032], 'G': [1035], 'attachment': [1036], 'nucleocapsid': [1038], 'proteins,': [1039, 1047], 'polymerase': [1041], 'subunit,': [1042], 'two': [1043, 3896, 4094], 'N': [1044], 'non-structural': [1046], 'M2-2,': [1049], 'regulatory': [1052], '(18Dickens': [1054], 'L.E.': [1055], 'Collins': [1056], 'P.L.': [1057], 'Wertz': [1058], 'G.W.': [1059, 2360, 2388, 2412, 2440, 2767, 2791, 2813, 3272], 'Virol.': [1061, 1119], '1984;': [1062], '52:': [1063], '364-369Crossref': [1064], 'signal': [1075], 'via': [1076, 1856, 1915], '(19Haeberle': [1078, 1168], 'H.A.': [1079, 1169], 'Takizawa': [1080, 1170], 'Casola': [1082, 1172], 'A.': [1083, 1173, 1338, 1402, 1709], 'Brasier': [1084, 1174], 'A.R.': [1085, 1175], 'Dieterich': [1086, 1176], 'H.J.': [1087, 1177], 'Van': [1088, 1178], 'Rooijen': [1089, 1179], 'Gatalica': [1091, 1181], 'Z.': [1092, 1182], 'Garofalo': [1093, 1183], 'R.P.': [1094, 1184, 1340, 1404, 1711], 'Infect.': [1096, 1186], 'Dis.': [1097, 1187], '186:': [1099, 1189], '1199-1206Crossref': [1100, 1190], '(208)': [1103, 1193], '20Haynes': [1106], 'Moore': [1108], 'D.D.': [1109, 1578], 'Kurt-Jones': [1110], 'E.A.': [1111, 1129], 'Finberg': [1112, 1148], 'R.W.': [1113, 1149], 'Anderson': [1114, 1146], 'L.J.': [1115, 1147], 'Tripp': [1116, 1138], 'R.A.': [1117, 1139], '75:': [1121], '10730-10737Crossref': [1122], '(402)': [1125], '21Kurt-Jones': [1128], 'Popova': [1130], 'L.': [1131, 1133, 1330, 1394, 1701], 'Kwinn': [1132], 'Haynes': [1134], 'Jones': [1136], 'L.P.': [1137], 'Walsh': [1140], 'E.E.': [1141], 'Freeman': [1142], 'M.W.': [1143, 2386, 2410, 3270], '398-401Crossref': [1154], '(1319)': [1157], 'Scholar),': [1159, 1195, 1591], 'Haeberle': [1165], 'et': [1166, 1636], 'al.': [1167, 1637], 'signaling': [1197], 'macrophages': [1199, 2346, 3704, 3797, 3857, 3913, 3956, 4013], 'was': [1200, 1946, 2006, 2105, 2116, 2123, 2490, 2513, 2569, 2575, 2584, 2648, 2705, 2713, 2731, 2751, 2834, 2897, 2914, 2977, 3011, 3017, 3074, 3079, 3127, 3145, 3169, 3183, 3205, 3342, 3387, 3397, 3551, 3569, 3613, 3629, 3661, 3673, 3789, 3973, 3996, 4019, 4088, 4185, 4215], 'be': [1203, 3422, 3724, 3936], 'important': [1205], 'component': [1206, 1370], 'shown': [1217, 1365, 3527, 4284], 'later': [1223], 'asthma,': [1226], 'but': [1227], 'presence': [1229, 1740, 2741, 4171], 'viral': [1236, 4331], 'infections': [1237], '(including': [1241], 'LPS).': [1242], 'asthmatic': [1248], 'RSV-infected': [1250], 'airways': [1251], 'possibility': [1254, 3922], 'alterations': [1256], 'inflammation-related': [1258], 'sequelae': [1262], 'phenotype.One': [1269], 'ubiquitous': [1270], 'clearly': [1274], 'triggers': [1275], 'acute': [1276, 2457], 'attacks': [1277], 'established': [1281, 1431], '22Braun-Fahrlander': [1319], 'Riedler': [1321, 1385, 1692], 'Herz': [1323, 1387, 1694], 'U.': [1324, 1388, 1478, 1493, 1523, 1533, 1695], 'Eder': [1325, 1389, 1696], 'W.': [1326, 1390, 1529, 1697], 'Waser': [1327, 1391, 1698], 'Grize': [1329, 1393, 1700], 'Maisch': [1331, 1395, 1702], 'S.': [1332, 1396, 1465, 1470, 1491, 1507, 1517, 1703], 'Carr': [1333, 1397, 1704], 'Gerlach': [1335, 1399, 1706], 'F.': [1336, 1400, 1527, 1707], 'Bufe': [1337, 1401, 1708], 'Lauener': [1339, 1403, 1710], 'Schierl': [1341, 1405, 1712], 'Renz': [1343, 1407, 1714], 'Nowak': [1345, 1409, 1716], 'von': [1347, 1411, 1466, 1540, 1718], 'Mutius': [1348, 1412, 1467, 1541, 1719], 'Engl.': [1351, 1415, 1722], 'Med.': [1353, 1417, 1652, 1724], '347:': [1355, 1419, 1726], '869-877Crossref': [1356, 1420, 1727], '(1514)': [1359, 1423, 1730], 'Various': [1362], 'it': [1367, 1744], 'household': [1372], 'dusts,': [1373], 'products': [1374], 'carbon': [1376], 'combustion,': [1377], 'grain': [1378], 'dust,': [1379], 'plant-derived': [1381], 'allergens': [1382], '(22Braun-Fahrlander': [1383, 1690], 'effect': [1427, 1601, 1735, 1763, 1826, 1917, 4040, 4157], 'clear.': [1434], 'There': [1435, 3901], 'controversy,': [1437], 'regarding': [1439], 'role': [1441, 1785], 'asthma.': [1448], 'Some': [1449], 'protects': [1457], 'from': [1459, 1771, 1868, 1933, 1941, 1948, 1958, 1988, 1999, 2008, 2019, 2027, 2042, 2092, 2147, 2278, 2308, 2349, 2528, 2564, 3827, 3960], '(23Illi': [1464], 'Lau': [1469, 1490], 'Bergmann': [1471, 1538], 'Niggemann': [1473, 1510], 'Sommerfeld': [1475, 1514], 'Wahn': [1477, 1492, 1522, 1534], 'BMJ.': [1479], '322:': [1481], '390-395Crossref': [1482], '(463)': [1485], '24Sengler': [1488], 'Nickel': [1494, 1508], 'Respir.': [1496, 1544, 1619], 'Res.': [1497], '7Crossref': [1500], '(104)': [1503], '25Lau': [1506], 'Gruber': [1512], 'Illi': [1516], 'Kulig': [1518], 'Forster': [1520], 'Groeger': [1524], 'Zepp': [1526], 'Kamin': [1528], 'Bieber': [1530], 'Tacke': [1532], 'V.': [1535], 'Bauer': [1536], 'C.P.': [1537], 'Paediatr.': [1543], '265-272Crossref': [1548], '(157)': [1551], '26Holla': [1554], 'A.D.': [1555], 'Roy': [1556], 'S.R.': [1557], 'Liu': [1558], 'A.H.': [1559], 'Allergy': [1562, 1581], 'Clin.': [1563, 1582], '2:': [1566, 1585], '141-145Crossref': [1567], '(29)': [1570], '27Stephens': [1573], 'Eisenbarth': [1575, 1635], 'S.C.': [1576, 1639], 'Chaplin': [1577], '31-37Crossref': [1586], '(33)': [1589], 'whereas': [1592], 'observations': [1594, 1781, 1875], 'provide': [1595], 'little': [1596], 'protective': [1600, 1777], '(28Vernooy': [1606], 'J.H.': [1607], 'Dentener': [1608], 'van': [1610], 'Suylen': [1611], 'R.J.': [1612], 'Buurman': [1613], 'W.A.': [1614], 'Wouters': [1615], 'E.F.': [1616], 'Am.': [1617, 2224, 3749], 'Cell': [1620, 2009, 2032, 2871, 3474], 'Mol.': [1621, 2172], '26:': [1624], '152-159Crossref': [1625], '(201)': [1628], '(29Eisenbarth': [1638], 'Piggott': [1640], 'D.A.': [1641], 'Huleatt': [1642], 'J.W.': [1643], 'Visintin': [1644], 'Herrick': [1646], 'Bottomly': [1648], 'Exp.': [1651], '196:': [1654], '1645-1651Crossref': [1655], '(980)': [1658], 'may': [1661, 1794], 'explain,': [1662], 'part,': [1664], 'conflicting': [1666], 'observations.': [1667], 'showed': [1669, 1758], 'dose': [1672, 1762, 1773], 'can': [1675, 3723], 'function': [1676, 1921], 'adjuvant': [1679, 1734], 'allergen-induced': [1681], 'Th2': [1682, 1768], 'murine': [1686], 'model': [1687], 'requires': [1738], 'does': [1745], 'occur': [1747], 'C3H/Hej': [1749], 'mice,': [1750], 'which': [1751, 2547], 'non-functional': [1754], '(facilitation': [1766], 'responses)': [1769], 'differs': [1770], 'high': [1772, 3084], 'facilitates': [1776], 'Th1': [1778], 'responses.': [1779], 'complicated': [1784], 'depend': [1795], 'number': [1798, 1890, 2192, 2205, 2625], 'interacting': [1800], 'factors,': [1801], 'including': [1802, 1895, 1928, 2718], 'dose,': [1803], 'genetics,': [1804], 'exposures.In': [1808], 'study,': [1810], 'we': [1811, 3847], 'evaluated': [1812, 2570, 2898, 3683, 4217], 'lung': [1819, 1853, 1865, 2037, 2140, 4137, 4206], 'line': [1822, 4106, 4139, 4146], 'then': [1824, 2526, 2631, 2915, 2933, 3045, 3586, 3641, 3649], 'findings': [1837], 'include:': [1841], 'RSV-induced': [1842, 4084], 'localization,': [1847], 'Golgi': [1858], 'transport-dependent': [1859], 'mechanism,': [1860], 'conversion': [1863], 'LPS-non-responsive': [1869], 'LPS-responsive': [1871], 'basic': [1874], '(increased': [1876], 'MD-2,': [1879, 3308, 3331], 'well': [1881], 'binding)': [1885], 'were': [1886, 1931, 1939, 1956, 1987, 1997, 2018, 2025, 2040, 2051, 2076, 2090, 2129, 2144, 2181, 2236, 2249, 2276, 2306, 2330, 2347, 2471, 2525, 2630, 2662, 2691, 2873, 2946, 2965, 2992, 3032, 3044, 3070, 3089, 3112, 3154, 3254, 3334, 3353, 3367, 3419, 3434, 3446, 3476, 3483, 3517, 3535, 3556, 3579, 3592, 3705, 3772, 3784, 3865, 3871, 3969, 3982, 4049, 4108, 4167, 4180, 4251, 4314, 4326], 'confirmed': [1887, 3398], 'lines,': [1894], 'newly': [1896, 4127], 'isolated': [1897, 2146, 2277, 3128, 4128], 'human': [1898, 2084, 2151, 2189, 3291, 3698, 3702], 'bronchotracheal': [1899], 'As': [1902, 3695], 'composite,': [1904], 'alters': [1911], 'receptor,': [1925], 'TLR4.EXPERIMENTAL': [1926], 'PROCEDURESMaterials—Chemicals,': [1927], 'brefeldin': [1929], 'A,': [1930, 4260], 'obtained': [1932, 1940, 1947, 1957, 1998, 2007, 2026, 2041, 2091, 2250, 2307, 2348, 2514, 2585, 2663], 'Sigma': [1934], 'Calbiochem.': [1936], 'Protease': [1937], 'inhibitors': [1938], 'Roche': [1942], 'Applied': [1943, 2616], 'Science.': [1944], 'LIST': [1949], 'Biologicals,': [1950], 'Campbell,': [1951], 'CA.': [1952], 'Antibodies': [1953, 1978], 'AbCam,': [1959], 'Cambridge,': [1960], 'UK': [1961], '(extracellular': [1962], 'domain)': [1963], 'Santa': [1965, 1969, 2020], 'Cruz': [1966, 2021], 'Biotechnology,': [1967], 'Inc.,': [1968, 2095], 'Cruz,': [1970], 'CA': [1971], '(intracellular': [1972], 'domain': [1973], 'TLR4/MD-2': [1975], 'complex': [1976], '(HTA-125)).': [1977], 'use': [1980], 'TNFα': [1985, 2989, 3016, 3073], 'ELISAs': [1986], 'R&D': [1989], 'Systems,': [1990], 'Minneapolis,': [1991], 'MN.': [1992], 'Nitrocellulose': [1993], 'ECL': [1995, 2971], 'Plus': [1996, 2972], 'Amersham': [2000], 'Biosciences.': [2001], 'Antibody': [2002], 'phosphorylated': [2004, 2747], 'ERK': [2005], 'Signaling,': [2010], 'Beverly': [2011], 'MA.': [2012], 'Other': [2013], 'antibodies': [2014, 2017, 4220], 'Biotechnology.': [2022], 'ALEXA-conjugated': [2023], 'reagents': [2024], 'Molecular': [2028], 'Probes,': [2029], 'Eugene,': [2030], 'OR.Epithelial': [2031], 'Culture': [2033, 2045], 'Viral': [2035, 2088], 'Infection—A549': [2036], 'American': [2043], 'Collection,': [2046], 'CCL-185,': [2047], 'Manassas,': [2048], 'VA.': [2049], 'Cells': [2050, 3578, 3680, 3831], 'maintained': [2052], '100-mm': [2054], 'tissue': [2055, 3542, 3547], 'culture': [2056, 3009, 3543, 3548], 'flasks': [2057], '(Corning,': [2058], 'Corning,': [2059], 'NY)': [2060], 'minimal': [2062], 'essential': [2063], 'medium': [2064, 2201, 2292, 2316], '10%': [2066, 2319, 2845, 2860], 'fetal': [2067, 2321], 'calf': [2068], 'serum.': [2069], 'For': [2070, 3438, 3563], 'infection,': [2071], '∼80%': [2074], 'confluency': [2075], 'treated': [2077, 3706], '1': [2079, 2612, 2697, 2929, 2955, 3459, 3792], '×': [2080, 2102, 2654, 3052, 3513], '106': [2081, 3040, 4254, 4317], 'TCID50': [2082, 4255, 4318], 'RSV,': [2085], 'strain': [2086], 'A-2.': [2087], 'stocks': [2089], 'Advanced': [2093], 'Biotechnologies': [2094], 'Columbia,': [2096], 'MD.': [2097], 'initial': [2099, 2680], 'stock': [2100], '(1': [2101, 3003, 3777], '109': [2103], 'TCID50)': [2104], 'aliquoted': [2106], 'kept': [2108], 'frozen': [2109], '-135': [2111], '°C.': [2112], 'fresh': [2114], 'aliquot': [2115], 'thawed': [2117], 'each': [2119, 3217, 3234, 3320, 3340, 3520, 3529], 'experiment.': [2120], 'never': [2124], 'refrozen.Other': [2125], 'Epithelial': [2126, 2274, 3679, 3830], 'Cells—All': [2127], 'protocols': [2128], 'approved': [2130, 2491], 'University': [2133, 2502, 3502], 'Iowa': [2135, 3504], 'Institutional': [2136], 'Review': [2137], 'Board.': [2138], 'Primary': [2139], '(HAE)': [2143], 'enzymatically': [2145], 'bronchial': [2148, 2197, 2281], 'donor': [2152], 'lungs,': [2153], 'described': [2155, 2252, 2338, 2353, 2754, 3257], 'previously': [2156, 2253, 2354, 2755, 3258], '(30Karp': [2157], 'P.H.': [2158], 'Moninger': [2159], 'T.O.': [2160, 2807], 'Weber': [2161], 'S.P.': [2162], 'Nesselhauf': [2163], 'T.S.': [2164], 'Launspach': [2165], 'J.L.': [2166], 'Zabner': [2167], 'Welsh': [2169, 2220], 'Methods': [2171], '188:': [2175], '115-137PubMed': [2176], 'cultured': [2182, 2287, 3063, 3774, 4168, 4334], 'collagen-coated': [2184], 'plastic': [2185], 'dishes': [2186, 3544], '(type': [2187], 'VI,': [2188], 'placental;': [2190], 'catalog': [2191], 'C-7521,': [2193], 'Sigma)': [2194], 'serum-free': [2196], 'growth': [2200], 'supplements': [2203], '(catalog': [2204, 2624], 'CC3170,': [2206], 'Clonetics/BioWhittaker)': [2207], '(31Zabner': [2208], 'Karp': [2210], 'Seiler': [2212], 'Phillips': [2214], 'S.L.': [2215], 'Mitchell': [2216], 'Saavedra': [2218], 'Klingelhutz': [2222], 'A.J.': [2223], 'Physiol.': [2226, 3751], '284:': [2228, 3753], 'L844-L854Crossref': [2229], '(135)': [2232], 'HAE': [2235], 'immediately': [2238], 'isolation': [2240, 3959], '(with': [2241], 'subculturing).': [2243], 'Human': [2244, 2343, 2498, 2506], '(hTBE)': [2248], '(32Joseph': [2254], 'T.D.': [2255], 'Look': [2256], 'D.C.': [2257], '276:': [2262], '47136-47142Abstract': [2263], '(35)': [2271], 'tracheal': [2279], 'mucosa': [2282], 'enzymatic': [2284], 'dissociation': [2285], 'Laboratory': [2289], 'Carcinogenesis-8e': [2291], 'plates': [2294, 3050, 3088, 3111], 'coated': [2295, 3090], 'collagen/albumin': [2297], 'up': [2300], 'passage': [2302], '10.': [2303], 'HeLa': [2304, 4310], 'ATCC': [2309], '(CCL-2)': [2310], 'grown': [2311, 3536], "Dulbecco's": [2313], 'modified': [2314], "Eagle's": [2315], 'supplemented': [2317], 'heat-inactivated': [2320], 'bovine': [2322], 'serum': [2323], '80': [2325], 'μg/ml': [2326, 3097, 3457], 'gentamycin.': [2327], 'All': [2328, 2478], 'lines': [2329, 4097, 4304, 4325], 'infected': [2331, 2993, 3033, 3435, 4050, 4109, 4252, 4315, 4327], 'subconfluent': [2335], 'conditions': [2336], 'A549': [2340, 3030, 3427, 3687, 3769, 3810, 3845, 3861, 3917, 3933, 3967, 4015, 4047, 4092, 4165, 4249, 4312], 'cells.Isolation': [2341, 3123], 'Alveolar': [2344, 3955], 'Macrophages—Alveolar': [2345], 'bronchoalveolar': [2350, 2466], 'lavage': [2351], '(33Monick': [2355], 'M.M.': [2356, 2378, 2400, 2430, 2759, 2785, 2811, 3260], 'Carter': [2357, 2379, 2407, 2431, 2764, 3267], 'A.B.': [2358, 2380, 2408, 2432, 2765, 3268], 'Hunninghake': [2359, 2387, 2411, 2439, 2766, 2790, 2812, 3271], '274:': [2365], '18075-18080Abstract': [2366], '(52)': [2374], '34Monick': [2377], 'Robeff': [2381, 2401, 3261], 'P.K.': [2382, 2402, 3262], 'Flaherty': [2383, 2405, 3265], 'D.M.': [2384, 2406, 3266], 'Peterson': [2385, 2409, 3269], '166:': [2392], '4713-4720Crossref': [2393], '35Monick': [2399], 'Butler': [2403, 2788, 2808, 3263], 'N.S.': [2404, 2789, 2809, 3264], '32992-33000Abstract': [2418, 3278], '(80)': [2426, 3286], '36Monick': [2429], 'Gudmundsson': [2433], 'Mallampalli': [2435], 'Powers': [2437, 2786, 2804], '162:': [2444], '3005-3012PubMed': [2445], 'Briefly,': [2448], 'volunteers': [2450, 2520, 3965], 'lifetime': [2453], 'non-smoking': [2454], 'history,': [2455], 'chronic': [2459], 'current': [2463], 'medications': [2464], 'underwent': [2465, 2522], 'lavage.': [2467], 'Differential': [2468], 'counts': [2470], 'determined': [2472, 3674], 'using': [2473, 2557, 2571, 2665, 2899, 2967, 3021, 3129, 3147, 3173, 3400, 3485, 3494, 3621, 3873, 4218, 4267], 'Wright-Giemsa-stained': [2475], 'cytocentrifuge': [2476], 'preparation.': [2477], 'preparations': [2480], 'had': [2481], '90': [2483], '100%': [2485], 'alveolar': [2486, 3703, 3764, 3796, 3856, 3912, 4012], 'macrophages.': [2487], 'Committee': [2494], 'Investigations': [2496], 'Involving': [2497], 'Subjects': [2499], 'Iowa.Isolation': [2504], 'Blood': [2507], 'Monocytes—180': [2508], 'ml': [2509, 2618], 'heparinized': [2511], 'blood': [2512, 2554, 3699, 3766, 3799], 'venipuncture': [2516], 'same': [2519, 3819, 4233], 'who': [2521], 'bronchoscopy.': [2523], 'Monocytes': [2524], 'separated': [2527], 'remaining': [2530], 'mononuclear': [2531], '(T': [2533], 'NK': [2535], 'etc.)': [2537], 'removal': [2539], 'all': [2541, 3364, 3773], 'non-monocytes': [2542], 'antibody': [2545, 2938, 2961, 3058, 3077, 3647, 3653, 4269], 'mixture,': [2546], 'cross-links': [2548], 'targeted': [2550], 'red': [2553], 'before': [2556, 3119, 4338], 'Ficoll-Hypaque': [2559], 'gradient': [2560], '(Sigma)': [2561], '(RosetteSep': [2562], 'mixture': [2563, 2623, 3213], 'StemCell': [2565], 'Technologies.': [2566], 'Monocyte': [2567], 'purity': [2568], 'Wright-Giemsa': [2572], 'staining': [2573, 2903, 2907, 3642], 'greater': [2576], 'than': [2577, 3814], '95%.Isolation': [2578], 'Protein': [2580], 'Extracts—Whole': [2581], 'lysing': [2587], 'ice': [2591], '20': [2593, 2634], 'min': [2594, 2722, 3599], '500': [2596], 'μl': [2597, 3202, 3209], 'lysis': [2599, 2668, 2716], 'buffer': [2600, 2669, 2717, 2840], '(0.05': [2601], 'm': [2602, 2607, 2852], 'Tris,': [2603, 2853], 'pH': [2604, 2854], '7.4,': [2605], '0.15': [2606], 'NaCl,': [2608], '1%': [2609, 3595], 'Nonidet': [2610], 'P-40,': [2611], 'protease': [2613], 'minitab': [2614], '(Roche': [2615], 'Science)/10': [2617], '1×': [2620], 'phosphatase': [2621], 'inhibitor': [2622], '524625,': [2626], 'Calbiochem).': [2627], 'lysates': [2629, 2690], 'sonicated': [2632], 's': [2635, 2984], 'incubated': [2637, 2934, 2953, 3447, 3557, 3570], '°C': [2640, 2725, 3094, 3607], '30': [2642, 2721, 2866], 'min,': [2643], 'insoluble': [2646], 'fraction': [2647, 4204], 'removed': [2649, 2732], 'centrifugation': [2651], '15,000': [2653], 'g': [2655], '10': [2657, 2983, 3815], 'min.': [2658], 'Cytosol/membrane': [2659, 4177], 'fractions': [2661, 4179], 'identical': [2667, 4330], 'except': [2670], 'detergent.': [2675, 2719], 'After': [2676, 2720], 'sonication': [2677], 'slow': [2681], 'spin': [2682], 'remove': [2684], 'nuclei': [2686, 3475], 'debris,': [2688], 'spun': [2692], '55,000': [2694], 'rpm': [2695], 'h': [2698, 2956, 3038, 3460, 4337], 'pellet': [2700, 2712], 'membranes.': [2702, 2911], 'supernatant': [2704, 3010], 'saved': [2706], 'cytosol,': [2708], 'resuspended': [2714], 'sonication,': [2728], 'debris': [2730], '14,000-rpm': [2735], 'spin.Western': [2736], 'Analysis—Western': [2737], 'analysis': [2738, 3660, 4184, 4262], 'forms': [2748], 'performed': [2752, 3080, 3255, 3662, 4186], '(37Thomas': [2756], 'K.W.': [2757], 'Monick': [2758, 2810], 'Staber': [2760], 'J.M.': [2761], 'Yarovinsky': [2762, 2806], 'T.': [2763, 2803], '492-501Abstract': [2773], '38Monick': [2784], '171:': [2795], '2625-2630Crossref': [2796], '(48)': [2799], '39Nyunoya': [2802], '278:': [2818], '36099-36106Abstract': [2819], '(19)': [2827], '50': [2830], 'μg': [2831, 3165], 'mixed': [2835], '1:1': [2836], '2×': [2838], 'sample': [2839, 3321, 3341, 3379], '(20%': [2841], 'glycerol,': [2842], '4%': [2843, 3472], 'SDS,': [2844], 'β-mercaptoethanol,': [2846], '0.05%': [2847], 'bromphenol': [2848], 'blue,': [2849], '1.25': [2851], '6.8)': [2855], 'loaded': [2857], 'onto': [2858, 3048], 'SDS-PAGE': [2861], 'gel': [2862], 'run': [2864], 'mA': [2867], '3': [2869], 'h.': [2870, 3007, 3068, 3562, 3781, 4176], 'transferred': [2874], 'nitrocellulose': [2876, 2910, 2913], 'Bio-Rad': [2879, 3189, 3496], 'semidry': [2880], 'transfer': [2881], 'system': [2882, 3192], 'according': [2883], "manufacturer's": [2886, 3023, 3142], 'instructions.': [2887, 3143], 'Equal': [2888, 3975], 'loading': [2889], 'groups': [2893], 'blots': [2896, 2945], 'Ponceau': [2900], 'S,': [2901], 'solution': [2904], 'designed': [2905], '5%': [2918], 'milk': [2919], 'TTBS': [2921, 2951], '(Tris-buffered': [2922], 'saline': [2923], '0.1%': [2925], 'Tween': [2926], '20)': [2927], 'h,': [2930, 4114], 'washed,': [2931], 'primary': [2937, 4095, 4136], 'dilutions': [2940, 3403], '1:500-1:2000': [2942], 'overnight.': [2943], 'washed': [2947, 3113, 3464, 3580], 'four': [2948, 3114, 4279, 4302], 'times': [2949, 2981, 3115, 3466, 3582, 4055], 'horseradish': [2958], 'peroxidase-conjugated': [2959], 'anti-IgG': [2960], '(1:5000-1:20,000).': [2962], 'Immunoreactive': [2963], 'bands': [2964], 'developed': [2966], 'chemiluminescent': [2969], 'substrate,': [2970], '(Amersham': [2973], 'Biosciences).': [2974, 3625], 'An': [2975], 'autoradiograph': [2976], 'obtained,': [2978, 4181], '2': [2986, 3201, 3215, 3877], 'min.IL-8': [2987], 'Release—A549': [2990], 'without': [2998], 'addition': [3000, 3120], 'μg/ml)': [3004, 3568, 3778], '5-24': [3006], 'saved,': [3012], 'measured': [3018], 'ELISA': [3020, 3666], 'instructions': [3024], '(R&D': [3025], 'Systems).TLR4': [3026], 'Cross-linking—In': [3027], 'studies,': [3029], '16': [3037, 4113, 4175, 4336], 'TCID50.': [3041], 'subcultured,': [3046], 'seeded': [3047], '96-well': [3049], '(5': [3051, 3567], '104/well)': [3053], 'precoated': [3054], 'anti-TLR4': [3056, 3098], '(HTA125)': [3057, 3099], 'control': [3060, 3103, 3375, 3384], 'antibody,': [3061], 'further': [3066], '24': [3067, 3780], 'Supernatants': [3069], 'harvested,': [3071], 'measured.': [3075], 'follows:': [3082, 3194], 'sterile': [3083], 'polystyrene': [3087], 'overnight': [3091], '3.3': [3096], 'isotype': [3102], '(anti-mouse': [3104], 'IgG,': [3105], 'Class': [3106], '2a)': [3107], 'PBS.': [3109], 'cold': [3117], 'PBS': [3118, 3584], 'RNA—Total': [3125], 'Absolutely': [3131], 'RT-PCR': [3133, 3159, 3175], 'Miniprep': [3134], 'kit': [3135, 3149, 3176], '(Stratagene,': [3136], 'La': [3137], 'Jolla,': [3138], 'CA)': [3139, 3490], 'following': [3140, 3637, 3929], 'quantitated': [3146], 'RiboGreen': [3148], '(Molecular': [3150, 3230], 'Probes).': [3151], 'samples': [3153, 3366, 3376], 'stored': [3155, 3601], '-70': [3157], '°C.Real-time': [3158], 'Detection': [3160], 'MD-2—1': [3164], 'total': [3167], 'reversed-transcribed': [3170], 'cDNA': [3172, 3182, 3204], 'RETROscript': [3174], '(Ambion,': [3177], 'Austin,': [3178], 'TX).': [3179], 'resulting': [3181], 'subjected': [3184], 'PCR': [3186, 3198, 3211, 3670], 'iCycler': [3190], 'iQ': [3191], '0.2-ml': [3197], 'tube': [3199], '(Bio-Rad),': [3200], 'added': [3206], '48': [3208], 'reaction': [3212], 'containing': [3214, 3406], 'mm': [3216, 3221], 'dNTP': [3218], '(Invitrogen),': [3219, 3223], '3.0': [3220], 'MgCl2': [3222], '1:15,000': [3224], 'SYBR': [3225], 'Green': [3226], 'DNA': [3228], 'dye': [3229], 'Probes),': [3231], '0.2': [3232], 'μm': [3233], 'sense': [3236], 'antisense': [3238], 'primers': [3239], '(IDT,': [3240], 'Coralville,': [3241], 'IA),': [3242], '2.5': [3244], 'units': [3245], 'Platimum': [3247], 'TaqDNA': [3248], '(Invitrogen).': [3249], 'Amplification': [3250], 'collection': [3253], '(35Monick': [3259], 'Primers': [3289], 'TLR4,': [3292, 3303, 3330, 4164], 'MD-2': [3293], 'HPRT': [3295, 3333, 3349, 3409, 3417, 3892, 3987], 'follows': [3299], '(5′': [3300], '3′):': [3302], 'forward,': [3304, 3309, 3314], 'ACA-ACC-TCC-CCT-TCT-CAA-CC;': [3305], 'reverse,': [3306, 3311, 3316], 'TGA-GAT-GTC-CAA-TGG-GGA-AG;': [3307], 'TTC-CAC-CCT-GTT-TTC-TTC-CA;': [3310], 'TCA-TCA-GAT-CCT-CGG-CAA-AT;': [3312], 'HPRT,': [3313, 4009], 'TTG-GAA-AGG-GTG-TTT-ATT-CCT-C;': [3315], 'TCC-CCT-GTT-GAC-TGG-TCA-TT.Quantitation': [3317], 'mRNA—For': [3319], 'assayed,': [3322], 'threshold': [3324], 'cycles': [3325], '(Ct)': [3326], 'reactions': [3328], 'amplifying': [3329], 'determined.': [3335], 'gene-specific': [3337], 'Ct': [3338, 3347], 'corrected': [3343], 'subtracting': [3345], '(ΔCt).': [3350], 'Untreated': [3351], 'controls': [3352], 'chosen': [3354], 'reference': [3357], 'samples,': [3358], 'ΔCt': [3361, 3371], 'values': [3362, 3372], 'experimental': [3365, 3407, 3415, 3521], 'subtracted': [3368], '(ΔΔCt).': [3377], 'Finally,': [3378], 'mRNA': [3380, 3385, 3854, 3869, 3883, 3885, 3909, 3952, 3978, 3988, 4004, 4074, 4117, 4292], 'calculated': [3388], 'formula': [3391], '2-(ΔΔCt).': [3392], 'Validity': [3393], 'approach': [3396], 'serial': [3401], '10-fold': [3402], 'template': [3405], 'genes.': [3410], 'amplification': [3412], 'efficiencies': [3413], 'amplimers': [3418], 'identical.Confocal': [3423], 'Microscopy—Subconfluent': [3424], 'cultures': [3425], 'Lab-Tek®': [3430], 'II': [3431], 'chamber': [3432], 'slides': [3433], 'uptake': [3442], 'assays,': [3443], 'ALEXA488-labeled': [3449], 'final': [3453, 3576], 'concentration': [3454], '5': [3456], '37': [3462], '°C,': [3463], 'several': [3465], 'PBS,': [3468], 'fixed': [3470, 3593], 'paraformaldehyde.': [3473], 'counterstained': [3477], '7-aminoactinomycin': [3479], 'Slide': [3481], 'chambers': [3482], 'cover-slipped': [3484], 'Vectashield®': [3486], '(Vector': [3487], 'Laboratories,': [3488], 'Burlingame,': [3489], 'analyzed': [3492, 3983, 4118], 'MRC-1024': [3497], 'confocal': [3498], 'microscope': [3499], 'Central': [3505], 'Microscopy': [3506], 'Research': [3507], 'Facility.': [3508], 'Ten': [3509], 'random': [3510], 'fields': [3511], '(512': [3512], '512': [3514], 'pixels': [3515], 'each)': [3516], 'collected': [3518], 'group.': [3522], 'representative': [3524, 4277], 'picture': [3525], 'condition.Flow': [3530], 'Cytometry': [3531], '(FACS)': [3532, 4226], 'Analysis—A549': [3533], '80%': [3538], 'confluence': [3539], '60-mm': [3541], '24-well': [3546], 'dishes,': [3549], 'added,': [3552], 'additional': [3560], '12-24': [3561], 'binding,': [3565], 'LPS-ALEXA488': [3566, 3612], 'hour.': [3577], 'three': [3581, 4021], 'harvested': [3587, 4057], 'trypsinization.': [3589], 'paraformaldehyde': [3596], '15': [3598], '70%': [3603], 'ethanol': [3604], '-20': [3606], 'until': [3608], 'analysis.': [3609], 'Analysis': [3610], 'done': [3614, 3630, 3997], 'flow': [3616], 'cytometry,': [3617], '(FACScan™,': [3618], 'BD': [3619], 'Biosciences)': [3620], 'CELLQuest': [3622], 'software': [3623], '(BD': [3624], 'Staining': [3626], 'harvesting': [3632], 'trypsinization': [3636], 'receptor-specific': [3646], 'secondary': [3652], 'conjugated': [3654], 'phycoerythrin': [3656], 'ALEXA488.Statistical': [3658], 'Analysis—Statistical': [3659], 'densitometry': [3664], 'data,': [3665], 'results,': [3667], 'real-time': [3669, 3874, 3990, 4120], 'data.': [3671], 'Significance': [3672], "Student's": [3676], 't': [3677], 'test.RESULTSLung': [3678], 'Are': [3681], 'LPS-tolerant—We': [3682], 'produce': [3690, 3801, 3946], 'comparison,': [3697], 'monocytes': [3700, 3800], 'LPS.': [3708], 'marker': [3717], 'produced': [3725, 3812, 3928], 'monocytes,': [3727, 3767], 'T': [3728], 'macrophages,': [3730, 3765], 'neutrophils,': [3731], 'endothelial': [3732], 'fibroblasts,': [3734], 'cytokines,': [3741], 'bacteria,': [3742], 'bacterial': [3743], 'products,': [3744], 'viruses': [3746], '(40Mukaida': [3747], 'L566-L577Crossref': [3754], '(350)': [3757], 'To': [3760, 4080, 4154], 'evaluate': [3761, 4155], 'responsiveness,': [3763], 'supernatants': [3783], 'collected,': [3785], 'analyzed.': [3790], 'Fig.': [3791, 3876, 4064, 4122], 'large': [3802], 'amounts': [3803, 3851, 3949, 3976, 4077], '(100-ng': [3804], 'range)': [3805], 'IL-8.': [3807], 'In': [3808], 'contrast,': [3809], 'less': [3813], 'ng/ml': [3816], 'time': [3820], 'frame.': [3821], 'amount': [3823, 4197], 'different': [3826], 'unstimulated': [3828], 'cells.Lung': [3829], 'Produce': [3832], 'Minimal': [3833], 'Amounts': [3834], 'mRNA—Because': [3837], 'next': [3848], 'compared': [3849, 3915], '(LPS-sensitive': [3858], 'cells)': [3859], 'versus': [3860], 'Unstimulated': [3863], 'isolated,': [3866], 'quantified': [3872], 'RT-PCR.': [3875, 3991, 4121], 'shows': [3878], 'ratio': [3880, 4001], 'housekeeping': [3889, 4007], 'gene,': [3890, 4008], 'HPRT.': [3891], 'types': [3898, 3995], 'comparable.': [3900], 'approximate': [3904], '1000-fold': [3905], 'difference': [3906], 'might': [3935], 'due': [3937], 'TLR4.Fig.': [3942], '2Airway': [3943], 'small': [3948], 'baseline.': [3954], 'shortly': [3957], 'lungs': [3962], 'lysed,': [3970], 'isolated.': [3974], '(see': [3979], '"Experimental': [3980], 'Procedures")': [3981], 'Comparison': [3992], 'determining': [3999], 'experiment': [4018], 'repeated': [4020], 'separate': [4022, 4280], 'times.View': [4023], 'Large': [4024], 'Image': [4025], 'Figure': [4026], 'ViewerDownload': [4027], 'Hi-res': [4028], 'image': [4029], 'Download': [4030], '(PPT)RSV': [4031], 'Increases': [4032], 'Expression': [4034], 'Membrane': [4036], 'Localization—To': [4037], 'investigate': [4038], 'expression,': [4046], 'various': [4054, 4258, 4321], 'whole': [4061, 4264], 'protein.': [4063], '3,': [4065], 'B,': [4068, 4291], 'demonstrate': [4069], 'increases': [4072, 4149], '(A549': [4078, 4305], 'cells).': [4079, 4311], 'determine': [4081], 'increase': [4085, 4194, 4234, 4287, 4297], 'specific': [4090], '(HAE': [4098], 'hTBE)': [4100], 'one': [4102], 'unrelated': [4103], '(HeLa)': [4107], '3B': [4123], 'that,': [4125], '(HAE),': [4132], 'non-transformed': [4135], '(hTBE),': [4140], 'adenocarcinoma': [4144], '(HeLa),': [4147], 'mRNA.': [4153], 'Western': [4183, 4261], 'caused': [4191], '(Fig.': [4209, 4238], '3C).': [4210], 'Surface': [4211], 'fluorescent': [4219], 'fluorescent-activated': [4223], 'sorter': [4225], 'non-permeabilized': [4228], '3D).Fig.': [4239], '3RSV': [4240], 'induces': [4242], 'times.': [4259, 4322], '(AbCam,': [4272], 'AB1436).': [4273], 'blot': [4275], 'experiments.': [4281], 'Densitometry': [4282], '-fold': [4286, 4296], '(experimental': [4288, 4298], 'value/control': [4289, 4299], 'value).': [4290], 'levels,': [4293], 'expressed': [4294], 'value)': [4300], 'HAE,': [4307], 'hTBE,': [4308], 'ha': [4339]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2025983848', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-14T02:17:06.105702', 'created_date': '2016-06-24'}