Publication Information

{'id': 'https://openalex.org/W2025919388', 'doi': 'https://doi.org/10.1016/s0168-3659(01)00309-1', 'title': 'Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS', 'display_name': 'Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS', 'publication_year': 2001, 'publication_date': '2001-07-01', 'ids': {'openalex': 'https://openalex.org/W2025919388', 'doi': 'https://doi.org/10.1016/s0168-3659(01)00309-1', 'mag': '2025919388', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11489482'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0168-3659(01)00309-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161954266', 'display_name': 'Journal of Controlled Release', 'issn_l': '0168-3659', 'issn': ['0168-3659', '1873-4995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080816054', 'display_name': 'Hiroshi Maeda', 'orcid': 'https://orcid.org/0000-0003-0999-4913'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Maeda', 'raw_affiliation_strings': ['Department of Microbiology, Kumamoto University School of Medicine, 860-0811, Kumamoto, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Kumamoto University School of Medicine, 860-0811, Kumamoto, Japan.', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019215364', 'display_name': 'Tomohiro Sawa', 'orcid': 'https://orcid.org/0000-0002-7949-7309'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomohiro Sawa', 'raw_affiliation_strings': ['Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, 860-0811, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, 860-0811, Japan', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111564601', 'display_name': 'Toshimitsu Konno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshimitsu Konno', 'raw_affiliation_strings': ['Department of Surgery, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan', 'institution_ids': ['https://openalex.org/I96036126']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4540, 'currency': 'USD', 'value_usd': 4540, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.561, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 888, 'citation_normalized_percentile': {'value': 0.636364, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '74', 'issue': '1-3', 'first_page': '47', 'last_page': '61'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11279', 'display_name': 'Lanthanide and Transition Metal Complexes', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanoplatforms for cancer theranostics', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/solid-tumor', 'display_name': 'Solid tumor', 'score': 0.5485585}], 'concepts': [{'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.6073903}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.6042163}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5971409}, {'id': 'https://openalex.org/C2993640289', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Solid tumor', 'level': 3, 'score': 0.5485585}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.47096306}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46018726}, {'id': 'https://openalex.org/C187961010', 'wikidata': 'https://www.wikidata.org/wiki/Q260463', 'display_name': 'Electron paramagnetic resonance', 'level': 2, 'score': 0.4245357}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41472733}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.2841636}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.13234615}, {'id': 'https://openalex.org/C46141821', 'wikidata': 'https://www.wikidata.org/wiki/Q209402', 'display_name': 'Nuclear magnetic resonance', 'level': 1, 'score': 0.09566662}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.07440004}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008299', 'descriptor_name': 'Maleic Anhydrides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011137', 'descriptor_name': 'Polystyrenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009353', 'descriptor_name': 'Zinostatin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D009353', 'descriptor_name': 'Zinostatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008299', 'descriptor_name': 'Maleic Anhydrides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008299', 'descriptor_name': 'Maleic Anhydrides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D008299', 'descriptor_name': 'Maleic Anhydrides', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011137', 'descriptor_name': 'Polystyrenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011137', 'descriptor_name': 'Polystyrenes', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011137', 'descriptor_name': 'Polystyrenes', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D009353', 'descriptor_name': 'Zinostatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009353', 'descriptor_name': 'Zinostatin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D009353', 'descriptor_name': 'Zinostatin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0168-3659(01)00309-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161954266', 'display_name': 'Journal of Controlled Release', 'issn_l': '0168-3659', 'issn': ['0168-3659', '1873-4995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11489482', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.58, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W139015031', 'https://openalex.org/W1522619862', 'https://openalex.org/W1592797175', 'https://openalex.org/W1871308790', 'https://openalex.org/W1899397722', 'https://openalex.org/W1907937440', 'https://openalex.org/W1964044673', 'https://openalex.org/W1972992205', 'https://openalex.org/W1973712257', 'https://openalex.org/W1977177125', 'https://openalex.org/W1981422827', 'https://openalex.org/W1983387455', 'https://openalex.org/W1989886196', 'https://openalex.org/W1990163407', 'https://openalex.org/W1998605301', 'https://openalex.org/W1999230659', 'https://openalex.org/W2001499176', 'https://openalex.org/W2002516695', 'https://openalex.org/W2004209335', 'https://openalex.org/W2007747310', 'https://openalex.org/W2012636494', 'https://openalex.org/W2015447656', 'https://openalex.org/W2028211453', 'https://openalex.org/W2036271174', 'https://openalex.org/W2037048276', 'https://openalex.org/W2045789731', 'https://openalex.org/W2051717913', 'https://openalex.org/W2057677923', 'https://openalex.org/W2059032684', 'https://openalex.org/W2062594120', 'https://openalex.org/W2069072174', 'https://openalex.org/W2078516817', 'https://openalex.org/W2092639730', 'https://openalex.org/W2094592590', 'https://openalex.org/W2116095996', 'https://openalex.org/W2117750432', 'https://openalex.org/W2143029029', 'https://openalex.org/W2153448522', 'https://openalex.org/W2154966823', 'https://openalex.org/W2157166246', 'https://openalex.org/W2209147002', 'https://openalex.org/W2268353674', 'https://openalex.org/W2315948693', 'https://openalex.org/W2335551827', 'https://openalex.org/W2411896501', 'https://openalex.org/W2460800439', 'https://openalex.org/W2607657276', 'https://openalex.org/W295091320', 'https://openalex.org/W4233820214', 'https://openalex.org/W602187624', 'https://openalex.org/W609957760'], 'related_works': ['https://openalex.org/W4295266695', 'https://openalex.org/W2993762413', 'https://openalex.org/W2084916282', 'https://openalex.org/W2082337540', 'https://openalex.org/W1994875143', 'https://openalex.org/W1981011544', 'https://openalex.org/W1654479263', 'https://openalex.org/W1585447513', 'https://openalex.org/W1542837180', 'https://openalex.org/W1516735584'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2025919388', 'counts_by_year': [{'year': 2024, 'cited_by_count': 28}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 41}, {'year': 2019, 'cited_by_count': 44}, {'year': 2018, 'cited_by_count': 36}, {'year': 2017, 'cited_by_count': 39}, {'year': 2016, 'cited_by_count': 73}, {'year': 2015, 'cited_by_count': 51}, {'year': 2014, 'cited_by_count': 66}, {'year': 2013, 'cited_by_count': 75}, {'year': 2012, 'cited_by_count': 57}], 'updated_date': '2024-12-20T05:07:04.702280', 'created_date': '2016-06-24'}