Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure

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Duration: 3 min 30 s
Description: The palladium-catalyzed arylation of different α-methylene-γ-lactone-containing sesquiterpene lactones was shown to produce E-olefin coupling products selectively in moderate to excellent yields. Biological evaluation of these semisynthetic sesquiterpene lactone derivatives in HeLa cells showed interesting antiproliferative profiles and provided initial structure−activity data.
Changho Han; Francis J. Barrios; Mark V. Riofski; David A. Colby
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