Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2025386975', 'doi': 'https://doi.org/10.1084/jem.135.1.68', 'title': 'GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN', 'display_name': 'GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN', 'publication_year': 1972, 'publication_date': '1972-01-01', 'ids': {'openalex': 'https://openalex.org/W2025386975', 'doi': 'https://doi.org/10.1084/jem.135.1.68', 'mag': '2025386975', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4109808', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2139116'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.135.1.68', 'pdf_url': 'https://rupress.org/jem/article-pdf/135/1/68/1084455/68.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jem/article-pdf/135/1/68/1084455/68.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047295711', 'display_name': 'Chester A. Alper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chester A. Alper', 'raw_affiliation_strings': ['Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'the Leary Laboratory, Boston, Massachusetts 02215'], 'affiliations': [{'raw_affiliation_string': "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'the Leary Laboratory, Boston, Massachusetts 02215', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060699234', 'display_name': 'Thomas Boenisch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Boenisch', 'raw_affiliation_strings': ['Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'the Leary Laboratory, Boston, Massachusetts 02215'], 'affiliations': [{'raw_affiliation_string': "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'the Leary Laboratory, Boston, Massachusetts 02215', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072715020', 'display_name': 'Lillian Watson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lillian Watson', 'raw_affiliation_strings': ['Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'the Leary Laboratory, Boston, Massachusetts 02215'], 'affiliations': [{'raw_affiliation_string': "From the Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115; and the Leary Laboratory, Boston, Massachusetts 02215", 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115', 'institution_ids': ['https://openalex.org/I136199984']}, {'raw_affiliation_string': 'the Leary Laboratory, Boston, Massachusetts 02215', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.103, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 526, 'citation_normalized_percentile': {'value': 0.992912, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '135', 'issue': '1', 'first_page': '68', 'last_page': '80'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tetramer', 'display_name': 'Tetramer', 'score': 0.48905024}, {'id': 'https://openalex.org/keywords/glycosylation', 'display_name': 'Glycosylation', 'score': 0.467985}, {'id': 'https://openalex.org/keywords/allotype', 'display_name': 'Allotype', 'score': 0.45595247}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.72328657}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.64742476}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.5472793}, {'id': 'https://openalex.org/C84597430', 'wikidata': 'https://www.wikidata.org/wiki/Q106227', 'display_name': 'Locus (genetics)', 'level': 3, 'score': 0.5448823}, {'id': 'https://openalex.org/C2778886173', 'wikidata': 'https://www.wikidata.org/wiki/Q53832', 'display_name': 'Tetramer', 'level': 3, 'score': 0.48905024}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.4868776}, {'id': 'https://openalex.org/C2780889450', 'wikidata': 'https://www.wikidata.org/wiki/Q1432692', 'display_name': 'Allotype', 'level': 3, 'score': 0.45595247}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.42046458}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.40408415}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23578978}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21660066}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0953832}], 'mesh': [{'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000939', 'descriptor_name': 'Epitopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005826', 'descriptor_name': 'Genetics, Medical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007125', 'descriptor_name': 'Immunogenetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008431', 'descriptor_name': 'Maternal-Fetal Exchange', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008967', 'descriptor_name': 'Molecular Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044469', 'descriptor_name': 'Racial Groups', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012737', 'descriptor_name': 'Sex Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.135.1.68', 'pdf_url': 'https://rupress.org/jem/article-pdf/135/1/68/1084455/68.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2139116', 'pdf_url': 'https://europepmc.org/articles/pmc2139116?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139116', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4109808', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.135.1.68', 'pdf_url': 'https://rupress.org/jem/article-pdf/135/1/68/1084455/68.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1481906796', 'https://openalex.org/W1493756313', 'https://openalex.org/W1495338174', 'https://openalex.org/W1531644278', 'https://openalex.org/W1905838633', 'https://openalex.org/W1996599929', 'https://openalex.org/W2009331031', 'https://openalex.org/W2013962510', 'https://openalex.org/W2022858282', 'https://openalex.org/W2029131085', 'https://openalex.org/W2032566319', 'https://openalex.org/W2043396888', 'https://openalex.org/W2052308950', 'https://openalex.org/W2065581822', 'https://openalex.org/W2074884255', 'https://openalex.org/W2088049642', 'https://openalex.org/W2143151997', 'https://openalex.org/W2149550178', 'https://openalex.org/W2336361427', 'https://openalex.org/W2396014084', 'https://openalex.org/W2442464748', 'https://openalex.org/W4231291566'], 'related_works': ['https://openalex.org/W4232685254', 'https://openalex.org/W2084669765', 'https://openalex.org/W2056840912', 'https://openalex.org/W2053919147', 'https://openalex.org/W2049240972', 'https://openalex.org/W2039101337', 'https://openalex.org/W1998707480', 'https://openalex.org/W1995051199', 'https://openalex.org/W1994903257', 'https://openalex.org/W1557502175'], 'abstract_inverted_index': {'Extensive': [0], 'polymorphism': [1], 'of': [2, 16, 71, 86, 94, 111, 115, 125, 130, 167], 'glycine-rich': [3], 'beta-glycoprotein': [4], '(GBG)': [5], 'was': [6, 58, 64, 74, 82], 'found': [7, 49, 59, 65, 160], 'in': [8, 50, 60, 66, 91, 101, 104, 142, 154, 161], 'human': [9], 'sera.': [10], 'In': [11], 'all': [12, 51], 'instances,': [13], 'GBG': [14, 80, 102, 131, 134, 180], 'consisted': [15], 'at': [17], 'least': [18], 'five': [19], 'components': [20], 'on': [21], 'electrophoresis.': [22], 'Patterns': [23], 'were': [24, 39, 48, 152, 159], 'such': [25], 'that': [26, 76, 78, 133, 179], 'they': [27], 'provided': [28], 'evidence': [29, 73], 'for': [30], 'four': [31], 'alleles': [32], '(at': [33], 'a': [34, 83, 92, 112, 120], 'locus': [35], 'designated': [36], 'Gb)': [37], 'which': [38], 'expressed': [40], 'as': [41], 'autosomal': [42], 'codominant': [43], 'traits.': [44], 'Gb(S)': [45], 'and': [46, 62, 88, 157], 'Gb(F)': [47], 'populations': [52], 'but': [53], 'with': [54], 'different': [55], 'frequencies,': [56], 'Gb(F1)': [57], 'Negroes,': [61], 'Gb(S1)': [63], 'Caucasians.': [67], 'From': [68], 'electrophoretic': [69], 'studies': [70, 124], 'GBG,': [72], 'obtained': [75], 'suggested': [77, 132], 'the': [79, 105, 109, 116, 162, 173, 184], 'molecule': [81, 117], 'tetramer': [84], 'consisting': [85], 'A': [87], 'B': [89], 'subunits': [90], 'proportion': [93], 'about': [95], '1.6:1.': [96], 'The': [97], 'genetically': [98], 'controlled': [99], 'differences': [100], 'embodied': [103], 'Gb': [106, 169], 'system': [107], 'indicated': [108, 178], 'presence': [110], 'third': [113], 'moiety': [114], '(C),': [118], 'possibly': [119], 'polypeptide': [121], 'subunit.': [122], 'Electrophoretic': [123], 'fragments': [126], 'from': [127], 'defined': [128], 'types': [129], 'cleavage': [135], 'induced': [136], 'by': [137], 'complement': [138], 'or': [139], 'properdin': [140], 'activation': [141], 'serum': [143], 'occurred': [144], 'through': [145], 'this': [146], 'C': [147], 'moiety,': [148], 'since': [149], 'two': [150, 158], 'variants': [151], 'detectable': [153], 'one': [155], 'fragment': [156], 'other': [163], 'fragment.': [164], 'On': [165], 'comparison': [166], 'fetal-maternal': [168], 'types,': [170], 'approximately': [171], 'one-half': [172], 'pairs': [174], 'showed': [175], 'differences.': [176], 'This': [177], 'did': [181], 'not': [182], 'cross': [183], 'placental': [185], 'barrier.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2025386975', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-11T13:37:02.420567', 'created_date': '2016-06-24'}