Title: The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration
Abstract: No dichlorovos could be detected in the blood of rats, mice, and humans after exposure to atmospheric concentrations of dichlorvos up to 17 times that normally attained for domestic insect control. Exposure of rats to 10 μg/liter (250 times normal exposure) for 4 hr was required before dichlorvos was found present; it was then measurable only in the kidneys of the animals. At about 90 μg/liter (2000 times normal exposure) dichlorvos could be detected in most tissues of the rat. The latter dichlorvos concentration is slightly more than 60% of full saturation of air at ambient conditions. The half-life of dichlorvos in the kidneys of male rats exposed to approximately 50 μg/liter for 4 hr was 13.5 min, indicating rapid degradation. Dichlorvos administered iv to rats was rapidly distributed, as it was following inhalation exposure. When mice were exposed to the high atmospheric concentrations of dichlorvos, the compound could be detected in most of the tissues examined, but male mouse kidneys contained only one-tenth of that found in male rat kidneys. In vitro, addition of dichlorvos to blood of rats, rabbits and humans similarly revealed a rapid degradation, which was catalyzed by enzymes in the plasma.
Publication Year: 1975
Publication Date: 1975-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 49
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