Publication Information

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2587, 2974], 'drug-eluting': [159, 214, 349, 439, 2128, 2374, 2553, 2639, 2677, 2750, 2861, 3012, 3039, 3082, 3129, 3174, 3213, 3247, 3358], 'stents': [160, 179, 215, 294, 334, 350, 440, 2025, 2297, 2300, 3040, 3043, 3083, 3214, 3218, 3248, 3251, 3359], 'still': [162], 'out.Article': [163], 'p': [164], '2071Progress': [165], 'linear': [169], 'for': [170, 312, 360, 853, 879, 1123, 1329, 1354, 1372, 1410, 1429, 1560, 1699, 1845, 1853, 1940, 1943, 1980, 1983, 2121, 2237, 2704, 2878, 3353, 3386, 3461], 'coronary': [171, 512, 933, 1366, 1399, 1431, 1460, 1489, 2131, 2308, 2349, 2457, 2520, 2792, 2804, 2848, 2932, 3006, 3133, 3362, 3517, 3525], 'stenting': [172, 424, 935, 1549, 2129, 2378, 2850, 3412], 'technology.': [173], 'The': [174, 251, 644, 863, 1108, 1261, 1583, 3436], 'introduction': [175, 208, 331, 872, 1323, 2030, 2859], '2': [177, 866, 1234, 1253, 1403, 1604, 1694, 1697, 1837, 1850, 1938], 'new': [178, 609, 2177], 'that': [180, 327, 385, 408, 465, 478, 484, 495, 717, 820, 895, 941, 983, 1052, 1155, 1182, 1228, 1317, 1406, 1414, 2035, 2048, 2098], 'largely': [181], 'prevented': [182], 'problem': [184], 'restenosis1,2': [186], 'was': [187, 491, 1293, 1368, 1557], 'met': [188], 'by': [189, 196, 200, 534, 787, 922, 1020, 1029, 1101, 1237, 1309, 1411, 1466, 1522, 2925, 2984], 'an': [190, 668, 969, 973, 1002, 1050, 1539, 1552], 'explosive': [191], 'adoption': [192, 397, 602], 'these': [194, 374, 399, 447, 451, 1185], 'techniques': [195, 679], 'physicians': [197], 'requests': [199], 'patients.': [201, 1143], 'Within': [202], 'first': [204], '8': [205], 'months': [206], 'Massachusetts,': [210, 3597], 'rate': [212], '(DES)': [216], 'a': [218, 235, 256, 322, 417, 492, 676, 771, 817, 850, 888, 981, 1068, 1134, 1159, 1169, 1177, 1370, 1496, 1558, 2306, 3364, 3369, 3553], 'proportion': [219, 1084, 2038], 'total': [221], 'stent': [222, 233, 664, 1650, 2345, 2600, 2671, 2751, 3132, 3385, 3494], 'procedures': [223, 314], 'reached': [224, 318], '90%.3': [225], 'However,': [226, 430, 1079], 'reports': [227, 432, 2047], 'late': [229, 1566, 2167], 'adverse': [230], 'events': [231, 2168], 'thrombosis,': [234, 3123], 'rare': [236], 'but': [237, 570, 989, 1165], 'morbid': [238], 'event,': [239], 'raised': [240], 'alarm': [241], 'patients': [243, 357, 421, 519, 896, 914, 1027, 1086, 1122, 1137, 1146, 1205, 1355, 1395, 1427, 1480, 1942, 2302, 2347, 2518, 2797, 2929, 2978, 3003, 3520, 3530], 'prompted': [245], 'caution': [246], 'from': [247, 1555, 1585, 1664, 2205, 2219, 2807, 2881, 3224, 3497], 'regulators': [248], 'physicians.': [250], 'net': [252], 'outcome': [253, 994, 1099], 'return': [257], 'increased': [259, 1565], 'use': [260, 266, 437, 691, 698, 769, 1353, 2637, 2675, 2744, 3211], 'bare-metal': [262, 293, 333, 503, 1548, 1640, 2024, 3042, 3131, 3217, 3250], 'stents,': [263], 'with': [264, 329, 887, 950, 1256, 1264, 1277, 1356, 1397, 1505, 1547, 1569, 1684, 1782, 1828, 1883, 1927, 2303, 2348, 2514, 2519, 2633, 2798, 2920, 2979, 3038, 3216, 3246, 3521], 'DES': [265, 291, 390, 415, 855, 874, 899, 931, 957, 1034, 1054, 1069, 1088, 1106, 1119, 1160, 1178, 1230, 1238, 1274, 1357, 1570, 1600, 1636, 1686, 1778, 1830, 1846, 1885, 1929, 2020], 'decreasing': [267], '64%': [269], 'United': [272], 'States': [273], '(Millenium': [274], 'Group,': [276], 'Waltham,': [277], 'Mass,': [278], 'written': [279], 'communication,': [280], '2007).The': [281], 'benefits': [282, 556, 607, 633], 'restenosis': [284, 317, 1520, 1615, 2163, 2586], 'prevention': [285, 1518], 'observed': [286], 'randomized': [288, 403, 550, 612, 662, 1212, 1524, 2112, 2445, 2549], 'comparing': [290, 1596], 'were': [295, 358, 367, 1342, 1481, 1784], 'far': [296], 'greater': [297, 2122], 'magnitude': [299], 'than': [300, 326, 913, 2088, 2091], 'many': [301], 'other': [302, 961, 1218, 1278, 1587], 'incremental': [303], 'changes': [304, 1280, 1334], 'medicine.': [306], 'Relative': [307], 'reductions': [308], 'need': [311, 2137, 3552], 'repeat': [313, 911], 'treat': [316], '75%': [319], '80%,1,2': [321], 'larger': [323], 'jump': [324], 'forward': [325], 'replace': [336], 'balloon': [337, 2451, 2515], 'angioplasty.4,5': [338], 'Although': [339, 1551, 2072], 'composite': [341], 'end': [342, 376, 785], 'points': [343, 786], 'pivotal': [346], 'included': [351, 1941], 'myocardial': [352, 907, 1544, 1643, 1655, 2593, 2981, 3124, 3415], 'infarction': [353, 908, 1545, 2594, 2982], 'death': [355, 905, 1542, 1567, 1612, 1805, 2591, 3127], 'followed': [359, 2924], '5': [361, 2053], 'years': [362, 1605, 1698], 'after': [363, 1458, 1576, 1808, 2595, 2749, 2857, 3128], 'stenting,': [364], 'powered': [369], 'detect': [371], 'harm': [372, 533], 'important': [375], 'points.6,7What': [377], 'Randomized': [378], 'Trials': [379], 'Tell': [380, 592], 'UsSome': [381], 'have': [382, 433, 524, 1167, 1319, 1391, 1511, 1571, 1606, 2026, 2049, 2058, 2069], 'voiced': [383], 'concern': [384], 'leading': [388], 'approval': [391, 406], 'did': [392], 'anticipate': [394], 'broad': [396], 'stents.': [400, 2554, 2640, 2678, 2862], 'Like': [401], 'most': [402], 'trials,': [404], 'studies': [407, 480, 522, 572, 1510, 1590, 2115], 'supported': [409], 'safety': [411, 635, 2126, 2230, 3080, 3170], 'efficacy': [413, 3172], 'enrolled': [416], 'narrow': [418, 619, 623], 'population': [419, 494], 'undergoing': [422, 506, 2930, 3004], 'single-vessel': [423, 507], 'stable': [426], 'or': [427, 532, 565, 773, 783, 1289, 1440, 1483, 1543, 1690, 1974, 2078, 2102, 2195, 3392], 'unstable': [428], 'angina.': [429], 'numerous': [431], 'since': [434, 860, 1321, 2028], 'outside': [441], 'parameters': [444], 'tested': [445], '(off-label': [449], 'use);': [450], 'off-label': [452, 2634, 2674], 'uses': [453], 'represent': [454], 'about': [455, 2143], 'half': [456], 'current': [458, 854], 'practice.8,9Randomized': [459], 'carefully': [462], 'designed': [463], 'experiments': [464], 'vary': [466], 'only': [467, 713], 'one': [468, 869, 876, 1040], 'condition': [469], 'between': [470, 930, 968, 1016, 1252, 1433, 1447], 'groups:': [471], 'assigned': [473], 'treatment.': [474], 'It': [475], 'appropriate': [477], 'human': [479], 'begin': [481], 'within': [482], 'populations': [483, 621, 1236], 'well-understood;': [486], 'this': [488, 542, 1198, 1330, 2144, 2186], 'case,': [489], 'it': [490, 1470], 'had': [496, 901, 1179], 'well-characterized': [498], 'era': [501, 900, 1164, 3010], 'stents:': [504, 3013, 3175], 'those': [505, 1208, 2191], 'treatment': [508, 632, 735, 758, 987, 996, 1008, 1017, 1037, 1188, 1215, 1258, 1290, 1827, 2455], 'de': [510, 2474, 3314], 'novo': [511], 'stenoses.': [513], 'An': [514, 978], 'attempt': [515, 847], 'include': [517, 689, 763], 'all': [518, 2238, 2242], 'could': [523, 1210], 'unintended': [526], 'consequence': [527], 'masking': [529], 'either': [530, 1214], 'combining': [535], 'heterogeneous': [536], 'effects': [537], 'treatment.The': [539], 'deficits': [540], 'strategy': [544, 920], 'generalizability': [546], 'power.': [548], 'Additional': [549], 'seek': [553], 'address': [555], 'risks': [558, 605], 'excluded': [563], 'subgroups': [564], 'define': [567], 'adjunctive': [568], 'therapy,': [569], 'necessary': [574], 'understand': [576, 1453, 1475], 'ultimate': [578], 'questions': [579, 2142, 2157], 'risk': [581, 1668], 'across': [584, 1591], 'full': [586], 'range': [587], 'practice.What': [589], 'Observational': [590, 1617, 2686], 'Studies': [591, 1618], 'UsA': [593], 'well-conducted': [594], 'study': [596, 1308, 2097], 'can': [597, 674, 752], 'provide': [598, 1731], 'valuable': [599], 'information': [600], 'regarding': [601, 2109, 2124], 'rates': [603, 630, 903], 'technologies.': [610], 'Because': [611, 808], '(appropriately)': [615], 'confined': [616], 'both': [618, 1036, 1608, 1685, 1783, 1829, 1884, 1928], 'physician': [624, 739], 'populations,': [625], 'expectation': [627], 'similar': [629, 1244], 'profiles': [636], 'usual': [639, 1262], 'care': [640, 1679, 2245], 'unrealistic.': [643], 'strong': [645], 'external': [646], 'validity': [647, 684], 'studies,': [650, 3499], 'however,': [651], 'pitted': [653], 'against': [654], 'their': [655, 861, 1130, 1304, 2029], 'weaker': [656, 2087], 'internal': [657, 683], 'validity:': [658], 'Patients': [659], 'types.': [665], 'old': [669], 'familiar': [671], 'problem.': [672], 'Researchers': [673], 'utilize': [675], 'variety': [677], 'bolster': [681], 'These': [688, 710, 762, 1144], 'different': [693, 1235, 1257, 1502, 1506], 'design': [694, 2077], 'adjustments:': [695], 'cross-sectional': [696], 'designs;': [697, 704], 'multiple': [700], 'comparison': [701, 2446, 2510, 3365], 'groups10;': [702], 'pre/post': [703], 'quasi-experimental': [705], 'designs11;': [706], 'landmark': [708], 'analyses.12,13': [709], 'strategies': [711], 'work': [712], 'extent': [716], 'additional': [718, 3254], 'adjustment': [719, 765, 778], 'methods': [720, 2084, 3367], 'balance': [721], 'groups': [723, 759, 1018, 1478], 'basis': [726], 'observable': [728], 'confounders.': [729, 1419], 'For': [730], 'example,': [731], 'more': [733, 744, 760, 1438, 1482, 1573, 1577, 2159], 'selection': [736], 'depends': [737, 1190], 'factors,': [742], 'susceptible': [745], 'analysis': [747, 819], 'bias.Analytical': [750], 'adjustments': [751], 'used': [754], 'make': [756], 'comparable.': [761], 'regression': [764, 775, 1412, 1797], '(such': [766, 779], 'Cox': [772, 889, 2322], 'logistic': [774], 'model);': [776], 'propensity-score': [777], 'matching,': [781], 'stratifying,': [782], 'weighting': [784, 2877], 'estimated': [789], 'propensity': [790, 1131], 'score)14;': [791], 'instrumental': [793, 1003, 1194], 'variables': [794, 975, 1004, 2873], 'adjustment.': [795], 'Standardized': [796], 'data': [797, 2080], 'collection': [798], 'tools': [799], 'complete': [801], 'follow-up': [802, 1578, 2064], 'required': [804], 'minimize': [806], 'bias.': [807], 'inability': [811], 'rule': [813], 'out': [814, 2061], 'unmeasured': [815, 824], 'confounders,': [816], 'sensitivity': [818], 'measures': [821], 'how': [822, 3527], 'much': [823], 'confounding': [825], 'must': [826, 832, 2116], 'exist': [827], 'refute': [829], 'findings': [831, 1563, 3223, 3496], 'performed.Another': [834], 'Piece': [835], 'PuzzleIn': [838], 'present': [840], 'issue': [841], 'Circulation,': [843, 3469, 3598], 'Hannan': [844, 1042, 1296, 1310, 1467, 2829, 3456], 'colleagues15': [846, 1044, 1298, 1312], 'answer': [849], 'fundamental': [851], 'question': [852], 'technology:': [856], 'Have': [857], 'outcomes': [858, 944, 1015, 1249, 1318, 1457, 1602, 2372, 2669, 2748, 2795, 2851, 3037, 3245], 'improved': [859, 943, 1320], 'introduction?': [862], 'authors': [864, 924, 1221], 'compare': [865], 'periods:': [868], 'before': [870, 2855], 'after.': [877], 'Controlling': [878], 'measured': [880, 1384, 1418], 'confounders': [881], '(patient,': [882], 'anatomic,': [883], 'hospital': [885], 'characteristics)': [886], 'proportional': [890, 1749, 1904, 2002], 'hazards': [891, 1750, 1905, 2003], 'model,': [892], 'they': [893, 1080, 1095, 1156], 'report': [894, 1082, 1554, 3014], 'lower': [902], 'revascularization': [912, 1692, 1976], 'prior': [917], 'era.The': [918], 'empirical': [919], 'adopted': [921], 'avoids': [925], 'directly': [926], 'estimating': [927], 'association': [929], 'artery': [934, 2350, 2458, 2521, 2849], 'outcomes.': [936, 1450], 'Rather,': [937], 'authors15': [939], 'suggest': [940], 'post-DES': [947, 1091, 1163], 'period': [948, 953, 1341], 'compared': [949, 1251, 1276, 1546, 3215], 'pre-DES': [952, 1072, 1173], 'due': [955], 'addition': [959], 'factors.': [962], 'Their': [963], 'statistical': [964], 'approach': [965, 1242], 'somewhere': [967], '"ecological': [970], 'approach"': [971], '"instrumental': [974], '(IV)': [976], 'approach."': [977], 'instrument': [979, 1031, 1051], 'variable': [982, 1195], 'predictive': [985, 991], 'assignment': [988, 1189], 'once': [995], 'taken': [998, 1344], 'into': [999, 1345], 'account.16': [1000], 'Intuitively,': [1001], 'estimate': [1005], 'effect': [1009, 1120, 1598], 'difference': [1012, 1022, 1422], 'mean': [1014, 1098], 'divided': [1019], 'fraction': [1025], 'predicted': [1028, 1105], 'receive': [1033, 1133, 1158, 1487], 'groups.On': [1038], 'hand,': [1041, 1219], 'almost': [1046], 'using': [1047, 1224], 'predicts': [1053], 'use.': [1055, 1107], 'They': [1056], 'assume': [1057], 'second': [1059], 'component': [1060], 'denominator,': [1063], 'probability': [1065, 2876], 'receiving': [1067, 1087], 'era,': [1073, 1092, 1174], '0': [1075], '(which': [1076], 'sensible).': [1078], 'never': [1081], 'nor': [1093], 'do': [1094], 'divide': [1096], 'differences': [1100, 1103, 1393], 'reason': [1109], 're-scale': [1111], 'numerator': [1113], 'appropriately': [1116, 1300], 'allocate': [1117], 'whom': [1124], 'there': [1125, 1326, 1389], 'variation': [1128], 'DES.': [1135], 'Such': [1136], 'referred': [1139, 1428], 'marginal': [1142, 1204], 'whose': [1147], 'medical,': [1148], 'demographic,': [1149], 'anatomic': [1151], 'characteristics': [1152], 'such': [1154], 'would': [1157, 1166, 1442, 1471], 'received': [1168, 2203, 2217], 'BMS': [1170, 1774, 1780, 1848, 1984], 'even': [1175], 'if': [1176], 'available;': [1181], 'is,': [1183, 1229], 'cases,': [1186], 'entirely': [1191], '(time': [1196], 'case).': [1199], 'In': [1200, 3285], 'sense,': [1202], 'correspond': [1206], 'who': [1209], 'strategy.On': [1216], 'basically': [1223], 'blocks': [1225], 'time,': [1227], 'eras,': [1231], 'characterize': [1233], 'penetration': [1239, 1259], 'rates.': [1240, 1260], 'ecological': [1246, 1265], 'analyses': [1247, 1266], 'where': [1248], 'geographic': [1254], 'areas': [1255], 'problems': [1263], 'apply': [1267], 'here;': [1268], 'relative': [1270, 1799, 2022], 'attributable': [1272], 'concomitant': [1279, 1360], 'medical': [1282, 1336], 'practice': [1283, 1530], '(eg,': [1284], 'duration': [1285], 'dual-antiplatelet': [1287], 'therapy': [1288, 1337, 1377, 2927], 'hyperlipidemia)': [1292], 'assessed.': [1295], 'cautious': [1301], 'interpreting': [1303], 'findings.': [1305], 'Regardless,': [1306], 'gives': [1313], 'holistic': [1315], 'conclusion': [1316], 'DES.Are': [1325], 'alternative': [1327], 'explanations': [1328], 'conclusion?': [1331], 'Yes.': [1332], 'First,': [1333], 'over': [1338, 1401, 1491], 'account.': [1346], 'Both': [1347], 'requirement': [1349], 'extended': [1351], 'clopidogrel': [1352, 1376, 2921], 'realization': [1361], 'acute': [1365, 1678, 2244, 2803, 2980, 3414, 3524], 'syndromes': [1367], 'likely': [1369, 1485], 'cause': [1371, 1559], 'longer': [1373], 'durations': [1374], 'later': [1380], 'period,': [1381], 'although': [1382, 1499], 'study.12,17': [1387], 'Second,': [1388], 'treated': [1396, 2240], 'percutaneous': [1398, 1430, 1459, 1488, 2931, 3005, 3361], 'interventions': [1400, 1461, 2236], 'periods': [1405], 'cannot': [1407], 'accounted': [1409], 'modeling': [1413], 'assumes': [1415], 'linearity': [1416], 'A': [1420, 2342, 2444, 2509, 3281, 3350], 'nonlinear': [1421], 'types': [1425], 'intervention': [1432, 1490, 3007], 'periods,': [1436], 'complex18': [1439], 'less,': [1441], 'further': [1443], 'confound': [1444], 'relationship': [1446], 'To': [1451, 2133], 'better': [1452], 'improvement': [1455], 'New': [1463, 1497, 2688, 2710, 2963], 'York': [1464, 2964], 'reported': [1465, 1665], 'et': [1468, 1673, 1724, 1762, 1814, 1877, 1920, 1968], 'al,15': [1469], 'helpful': [1473], 'certain': [1477], 'less': [1484], 'time.Are': [1492], 'Getting': [1495], 'Look?Overall,': [1498], 'performed': [1500], 'locations': [1503], 'methods,': [1507], 'recent': [1508], 'shown': [1512, 1607], 'reassuring': [1513], 'results;': [1514], 'general,': [1516], 'promised': [1521], 'evident': [1527], 'does': [1532], 'come': [1534], 'expense': [1537], 'increase': [1540, 1610], '(Table).': [1550], 'early': [1553], 'Sweden': [1556], 'alarm,20': [1561], 'associated': [1568, 2632], 'recently': [1574], 'reversed': [1575], 'same': [1581], 'study.25': [1582], 'results': [1584, 2806, 3177], 'several': [1586], 'independent': [1588], 'population-based': [1589], 'North': [1592], 'America': [1593], 'Europe': [1595], 'no': [1609, 2073], 'preserved': [1614], 'benefit.3,21–23Table.': [1616], 'DES,': [1620, 1981, 2110], '2006': [1621], '2007StudyLocationTotal': [1623], 'NDES': [1624], 'n': [1625], '(%)Exclusion': [1626], 'CriteriaMain': [1627], 'End': [1628], 'PointsCompleteness': [1629], 'Follow-UpGroups': [1631], 'ComparedAdjustment': [1632], 'MethodTreatment': [1633], 'Difference': [1634], 'Between': [1635], 'BMSBMS': [1638], 'indicates': [1639], 'stent;': [1641], 'MI,': [1642, 1689, 1716, 1833, 1871, 1888, 1912, 1933, 1959, 1973, 2010], 'infarction;': [1644], 'TVR,': [1645, 1758, 1874, 1934, 1962], 'target': [1646], 'vessel': [1647], 'revascularization;': [1648], 'ST,': [1649, 1916, 1965], 'thrombosis;': [1651], 'STEMI,': [1653], 'ST-segment': [1654, 2801], 'infarction.': [1656], 'Values': [1657], 'brackets': [1659], '95%': [1661], 'confidence': [1662], 'intervals.*Estimated': [1663], 'numbers': [1666, 1670], 'deaths.Mauri': [1672], 'al,': [1674, 1725, 1763, 1815, 1878, 1921, 1969], '20073All': [1675], 'Massachusetts': [1676, 2221], 'non-federal': [1677], 'hospitals17': [1680], '72611': [1681], '516': [1682], '(65)Treatment': [1683], 'BMSDeath,': [1688, 1832, 1887], 'any': [1691, 1975], 'years100%': [1695, 1838, 1939], 'mortalityDES': [1700, 1854, 1944], 'vs': [1701, 1742, 1779, 1855, 1894, 1945, 1988], 'BMS,': [1702, 1743, 1856, 1895, 1946, 1989], 'concurrent,': [1703, 1744, 1788, 1857, 1896, 1947], 'April': [1704, 3606], '2003': [1705, 1791, 1860], 'through': [1706, 1746, 1792, 1861, 1900, 1950, 1993, 1999], 'December': [1707, 1793, 1858], '2004Propensity': [1708, 1795], 'score–matched': [1709], 'analysisRate': [1710], 'differences:': [1711, 1867, 1955], 'death,': [1712, 1908, 1956], '−2.5%': [1713], '[−3.6%,': [1714], '−1.3%];': [1715], '−1.8%': [1717], '[−2.8%,': [1718], '−0.7%];': [1719], 'revascularization:': [1720, 2014], '−5.4%': [1721], '[−6.9%,': [1722], '−3.9%]Williams': [1723], '200619Selected': [1726], 'US': [1727, 1971], 'hospitals69066509': [1728], '(94)Inability': [1729], 'informed': [1732], 'consentComposite': [1733], 'death+MI;': [1734], 'TVR': [1735, 1835], '1': [1737, 1740, 1822, 1840, 1978, 1986, 2271], 'year89.6%': [1738], 'yearDES': [1741, 1987], 'January': [1745, 1789, 1897], 'June': [1747, 1901, 1951], '2005Cox': [1748, 1903], 'adjustmentAdjusted': [1751, 1798], 'hazard': [1752], 'ratio:': [1753, 1907, 2005], 'death+MI,': [1754], '0.74': [1755], '[0.52,': [1756], '1.07];': [1757], '0.58': [1759], '[0.40,': [1760], '0.83]Lagerquivst': [1761], '200720Sweden19': [1764], '7716033': [1765], '(31)None': [1766], 'reportedComposite': [1767], 'death+MI': [1768], '3': [1770, 1776], 'years18%': [1771], 'DES;': [1772], '33%': [1773], 'years*Any': [1777], '(patients': [1781], 'classified': [1785], 'DES),': [1787], '1,': [1790, 1859, 1898], '31,': [1794, 1863], 'score': [1796, 1865, 1953], 'risk:': [1800], 'death:': [1801, 1868, 2006], '1.18': [1802], '[1.04,': [1803], '1.35];': [1804], 'MI': [1807], '6-mo': [1809], 'landmark,': [1810], '1.2': [1811], '[1.05,': [1812], '1.37]Tu': [1813], '200721Ontario13': [1816], '3535106': [1817], '(38)PCI': [1818], 'past': [1821, 2052], 'year;': [1823], 'left': [1824], 'main': [1825], 'disease;': [1826], 'year,': [1841], '74%': [1842], '72%': [1844], 'years,': [1851, 2054], 'respectively,': [1852], 'March': [1862, 2000], '2005Propensity': [1864, 1952], 'matchingRate': [1866], '−2.2%': [1869], '(P<0.001);': [1870], '0.5%': [1872], '(P=0.95);': [1873], '−3.3%': [1875], '(P<0.001)Jensen': [1876], '200722Western': [1879], 'Denmark12': [1880], '3953548': [1881], '(29)Treatment': [1882, 1926], 'ST': [1890, 1936], '15': [1892], 'months100%DES': [1893], '2002': [1899, 1949], '30,': [1902], 'adjustmentHazard': [1906, 2004], '0.90': [1909], '[0.75,': [1910], '1.29];': [1911], '1.14': [1913], '[0.89,': [1914], '1.45];': [1915], '0.91': [1917], '[0.67,': [1918], '1.24]Marzocchi': [1919], '200723Emilia,': [1922], 'Romagna,': [1923], 'Italy10': [1924], '6293064': [1925], 'BMS;': [1931], 'STEMIDeath,': [1932], 'July': [1948], 'matchingRisk': [1954], '−0.6%': [1957], '(P=0.35);': [1958], '−0.5%': [1960], '(P=0.46);': [1961], '−3.8%': [1963], '(P<0.00001);': [1964], '0.4%': [1966], '(P=0.09)Abbott': [1967], '200724Selected': [1970], 'centers32231460Death,': [1972], 'year96%': [1979], '83%': [1982], 'nonconcurrent;': [1990], 'DES:': [1991], 'February': [1992], 'May': [1994], '2004,': [1995], 'BMS:': [1996], 'October': [1997], '2001': [1998], '2002Cox': [2001], '0.97': [2007], '[0.66,': [2008], '1.43];': [2009, 2013], '1.02': [2011], '[0.73,': [2012], '0.38': [2015], '[0.25,': [2016], '0.60]ConclusionDramatic': [2017], 'shifts': [2018], 'usage': [2021], 'occurred': [2027], '2003.': [2032], 'suggests': [2034], 'vast': [2037], 'cardiologists': [2040, 2043], 'responding': [2045], 'punctuated': [2050], 'borne': [2060], 'longer-term': [2063], 'reversed.': [2071], 'single': [2074], 'method': [2075], 'analyze': [2079], 'correct,': [2082], 'others.': [2089], 'Rather': [2090], 'having': [2092], 'each': [2093], 'individual': [2094], 'choose': [2095], 'suits': [2099], 'what': [2100], 'he': [2101], 'she': [2103], 'expects': [2104], 'truth': [2108], 'well-designed': [2111], 'respond': [2117], 'demand': [2120], 'knowledge': [2123], 'intervention.': [2132], 'sure,': [2135], 'we': [2136, 3551], 'continue': [2139], 'ask': [2141], 'newer': [2148], 'iterations': [2149], 'concept.': [2152], 'As': [2153], 'improves,': [2155], 'become': [2158], 'refined,': [2160], 'moving': [2161], 'beyond': [2162], 'understanding': [2165], 'appreciation': [2171], 'implications': [2174], 'adopting': [2176], 'general': [2181], 'population.The': [2182], 'opinions': [2183], 'expressed': [2184], 'article': [2187], 'necessarily': [2190], 'editors': [2194], 'American': [2198, 2385], 'Heart': [2199, 2386, 2988, 3395], 'Association.DisclosuresDr': [2200], 'honoraria': [2204], 'Abbott': [2206, 2996, 3192], 'Vascular,': [2207], 'Boston': [2208], 'Scientific,': [2209], 'Cordis,': [2210], 'Medtronic': [2212], 'Vascular.': [2213], 'Dr': [2214], 'funding': [2218], 'Department': [2222], 'monitor': [2227], 'quality': [2228], 'cardiac': [2232, 2235], 'surgery': [2233], 'adults': [2239], 'nonfederal': [2243], 'hospitals': [2246], 'Commonwealth': [2249], 'Massachusetts.FootnotesCorrespondence': [2251], 'MSc,': [2256], 'Hospital,': [2260], '75': [2261], 'Francis': [2262], 'St,': [2263], 'MA': [2265], '02115.': [2266], 'E-mail': [2267], '[email': [2268], 'protected]': [2269], 'References': [2270], 'Moses': [2272, 2430], 'JW,': [2273], 'Leon': [2274, 2398], 'MB,': [2275, 2399], 'Popma': [2276, 2338], 'JJ,': [2277, 2339, 2500, 2779], 'Fitzgerald': [2278], 'PJ,': [2279], 'Holmes': [2280, 2833], 'DR,': [2281, 2834], "O'Shaughnessy": [2282, 2326], 'C,': [2283, 2327, 2480, 3073], 'Caputo': [2284, 2332], 'RP,': [2285], 'Kereiakes': [2286], 'DJ,': [2287, 2665], 'Williams': [2288, 2627, 2994, 3208], 'DO,': [2289, 2995], 'Teirstein': [2290, 2422], 'PS,': [2291, 2423], 'Jaeger': [2292], 'JL,': [2293], 'Kuntz': [2294], 'RE.': [2295], 'Sirolimus-eluting': [2296], 'versus': [2298, 3041], 'standard': [2299], 'stenosis': [2304], 'native': [2307], 'artery.': [2309], 'N': [2310, 2352, 2464, 2526, 2555, 3046, 3086], 'Engl': [2311, 2353, 2465, 2527, 2556, 3047, 3087], 'J': [2312, 2354, 2466, 2528, 2557, 3048, 3088, 3135, 3234], 'Med.': [2313, 2355, 2467, 2529, 2558, 3049, 3089], '2003;': [2314], '349:': [2315], '1315–1323.CrossrefMedlineGoogle': [2316], 'Scholar2': [2317], 'Stone': [2318, 2563, 3409], 'GW,': [2319, 2564], 'Ellis': [2320, 2438, 2565], 'SG,': [2321, 2566, 2787], 'DA,': [2323], 'Hermiller': [2324], 'J,': [2325, 2337, 2429, 2431, 2435, 2488, 2494, 2506, 2653, 2869, 2955, 3031, 3057], 'Mann': [2328], 'JT,': [2329], 'Turco': [2330], 'M,': [2331, 2415, 2417, 2576, 2832, 3059, 3097, 3105, 3197, 3345, 3427], 'R,': [2333, 2419, 2441, 2543, 3067, 3166, 3343, 3575], 'Bergin': [2334], 'P,': [2335, 2476, 2492, 2759, 3101, 3162, 3164], 'Greenberg': [2336, 2944], 'Russell': [2340], 'ME.': [2341], 'polymer-based,': [2343], 'paclitaxel-eluting': [2344, 2596], 'disease.': [2351, 2459, 2522], '2004;': [2356, 2889], '350:': [2357], '221–231.CrossrefMedlineGoogle': [2358], 'Scholar3': [2359], 'L,': [2361, 2411, 2535, 2614, 3115, 3486, 3571], 'Silverstein': [2362], 'T,': [2363, 3033, 3573], 'Lovett': [2364, 3578], 'A,': [2365, 2427, 2433, 2498, 2568, 2775, 3099, 3144, 3150, 3154, 3156, 3429, 3480, 3579], 'Resnic': [2366, 3582], 'FS,': [2367], 'S-LT.': [2369], 'Long-term': [2370, 3036, 3169, 3244], 'following': [2373, 2673], 'bare': [2376, 2598], 'metal': [2377, 2599], 'Massachusetts.': [2380], 'Presented': [2381, 3258], '2007': [2384, 3261], 'Association': [2387], 'Scientific': [2388], 'Sessions;': [2389], 'November': [2390], '4–7,': [2391], '2007;': [2392, 2559, 2603, 2642, 2680, 2754, 2812, 2825, 3050, 3090, 3139, 3188, 3238, 3269], 'Orlando,': [2393], 'Fla.Google': [2394], 'Scholar4': [2395], 'Fischman': [2396], 'DL,': [2397], 'Baim': [2400, 2577], 'DS,': [2401, 2578], 'Schatz': [2402], 'RA,': [2403, 2732, 2785, 2943], 'Savage': [2404], 'MP,': [2405], 'Penn': [2406], 'I,': [2407, 2914], 'Detre': [2408], 'K,': [2409, 2651, 2906, 3111, 3577], 'Veltri': [2410], 'Ricci': [2412], 'D,': [2413, 2421, 2663], 'Nobuyoshi': [2414], 'Cleman': [2416], 'Heuser': [2418], 'Almond': [2420], 'Fish': [2424], 'RD,': [2425], 'Colombo': [2426, 2497, 2567], 'Brinker': [2428], 'Shaknovich': [2432], 'Hirshfeld': [2434], 'Bailey': [2436], 'S,': [2437, 2439, 2661, 2838, 2840, 2896, 2912], 'Rake': [2440], 'Goldberg': [2442], 'S.': [2443, 3243], 'coronary-stent': [2448], 'placement': [2449], 'angioplasty': [2452, 2516], 'Stent': [2460, 2546, 3122], 'Restenosis': [2461], 'Study': [2462, 2524], 'Investigators.': [2463], '1994;': [2468, 2530], '331:': [2469, 2531], '496–501.CrossrefMedlineGoogle': [2470], 'Scholar5': [2471], 'Serruys': [2472], 'PW,': [2473], 'Jaegere': [2475], 'Kiemeneij': [2477], 'F,': [2478, 2910, 3146, 3201, 3484], 'Macaya': [2479], 'Rutsch': [2481], 'W,': [2482], 'Heyndrickx': [2483], 'G,': [2484, 2836, 3071, 3148, 3158, 3478], 'Emanuelsson': [2485], 'H,': [2486, 2908], 'Marco': [2487], 'Legrand': [2489], 'V,': [2490], 'Materne': [2491], 'Belardi': [2493], 'Sigwart': [2495], 'U,': [2496, 3029], 'Goy': [2499], 'van': [2501], 'den': [2502], 'Heuve': [2503], 'Pl,': [2504], 'Delcan': [2505], 'Morel': [2507], 'MA.': [2508], 'balloon-expandable-stent': [2512], 'implantation': [2513], 'Benestent': [2523], 'Group.': [2525], '489–495.CrossrefMedlineGoogle': [2532], 'Scholar6': [2533], 'Hsieh': [2536], 'WH,': [2537], 'Massaro': [2538], 'JM,': [2539, 2730], 'Ho': [2540], 'KK,': [2541], "D'Agostino": [2542, 2816], 'Cutlip': [2544, 2573], 'DE.': [2545], 'thrombosis': [2547, 2584, 2672], '356:': [2560, 3051], '1020–1029.CrossrefMedlineGoogle': [2561], 'Scholar7': [2562], 'Dawkins': [2569], 'KD,': [2570], 'Grube': [2571], 'E,': [2572, 3152, 3160, 3482], 'DE,': [2574, 2736], 'Friedman': [2575], 'Koglin': [2579], 'J.': [2580, 2989], 'Offsetting': [2581], 'impact': [2582], 'occurrence': [2589], 'implantation.': [2601, 2752], 'Circulation.': [2602, 2811, 2824, 2863, 3019, 3187], '115:': [2604, 2826, 3189], '2842–2847.LinkGoogle': [2605], 'Scholar8': [2606], 'Beohar': [2607], 'N,': [2608], 'Davidson': [2609], 'CJ,': [2610], 'Kip': [2611, 2998, 3202], 'KE,': [2612, 3203], 'Goodreau': [2613], 'Vlachos': [2615, 3204], 'HA,': [2616, 3199, 3205], 'Meyers': [2617], 'SN,': [2618], 'Benzuly': [2619], 'KH,': [2620], 'Flaherty': [2621], 'JD,': [2622, 2997, 3193], 'Ricciardi': [2623], 'MJ,': [2624, 2957], 'Bennett': [2625], 'CL,': [2626], 'DO.': [2628, 3209], 'Outcomes': [2629, 3000, 3465, 3590], 'complications': [2631], 'untested': [2636], 'JAMA.': [2641, 2679, 2753], '297:': [2643, 2681, 2755], '1992–2000.CrossrefMedlineGoogle': [2644], 'Scholar9': [2645], 'Win': [2646], 'HK,': [2647], 'Caldera': [2648], 'AE,': [2649], 'Maresh': [2650], 'Lopez': [2652], 'Rihal': [2654], 'CS,': [2655], 'Parikh': [2656], 'MA,': [2657, 2945, 2947], 'Granada': [2658], 'JF,': [2659, 3107], 'Marulkar': [2660], 'Nassif': [2662], 'Cohen': [2664, 3074, 3198], 'Kleiman': [2666, 2770], 'NS.': [2667], '2001–2009.CrossrefMedlineGoogle': [2682], 'Scholar10': [2683], 'Rosenbaum': [2684], 'PR.': [2685], 'Studies.': [2687], 'York,': [2689, 2711], 'NY:': [2690, 2712], 'Springer;': [2691], '2002.Google': [2692], 'Scholar11': [2693], 'Shadish': [2694], 'WR,': [2695], 'Cook': [2696], 'TD,': [2697], 'Campbell': [2698], 'DT.': [2699], 'Experimental': [2700], 'Quasi-Experimental': [2702], 'Designs': [2703], 'Generalized': [2705], 'Causal': [2706], 'Inference.': [2707], '2nd': [2708], 'ed.': [2709], 'Houghton': [2713], 'Mifflin;': [2714], '2001.Google': [2715], 'Scholar12': [2716], 'Eisenstein': [2717], 'EL,': [2718, 2830], 'Anstrom': [2719], 'KJ,': [2720], 'Kong': [2721], 'DF,': [2722], 'Shaw': [2723], 'LK,': [2724, 2783], 'Tuttle': [2725], 'RH,': [2726, 2842], 'Mark': [2727], 'DB,': [2728, 2734], 'Kramer': [2729], 'Harrington': [2731, 2784], 'Matchar': [2733], 'Kandzari': [2735], 'Peterson': [2737], 'ED,': [2738], 'Schulman': [2739], 'KA,': [2740], 'Califf': [2741, 2776], 'RM.': [2742], 'Clopidogrel': [2743], 'long-term': [2746, 2926], '159–168.CrossrefMedlineGoogle': [2756], 'Scholar13': [2757], 'Tricoci': [2758, 3512], 'Lokhnygina': [2760], 'Y,': [2761, 3065], 'Berdan': [2762], 'LG,': [2763], 'Steinhubl': [2764], 'SR,': [2765, 2894], 'Gulba': [2766], 'DC,': [2767], 'White': [2768], 'HD,': [2769], 'NS,': [2771], 'Aylward': [2772], 'PE,': [2773], 'Langer': [2774], 'RM,': [2777], 'Ferguson': [2778], 'Antman': [2780], 'EM,': [2781], 'Newby': [2782], 'Goodman': [2786], 'Mahaffey': [2788], 'KW.': [2789], 'Time': [2790, 3515], 'angiography': [2793, 3518], 'among': [2796], 'high-risk': [2799], 'non': [2800], 'elevation': [2802, 3523], 'syndromes:': [2805], 'SYNERGY': [2809], 'trial.': [2810], '116:': [2813], '2669–2677.LinkGoogle': [2814], 'Scholar14': [2815], 'RB': [2817], 'Jr.': [2818], 'Propensity': [2819], 'scores': [2820], 'cardiovascular': [2822], 'research.': [2823], '2340–2343.LinkGoogle': [2827], 'Scholar15': [2828], 'Racz': [2831], 'Walford': [2835], 'Sharma': [2837], 'Katz': [2839], 'Jones': [2841], 'King': [2843, 3381, 3453], 'SB': [2844], '3rd.': [2845], 'Comparison': [2846], 'eras': [2854], '2008;': [2864, 2990], '117:': [2865], '2071–2078.LinkGoogle': [2866], 'Scholar16': [2867], 'Hogan': [2868], 'Lancaster': [2870], 'Instrumental': [2872], 'inverse': [2875], 'causal': [2879], 'inference': [2880], 'longitudinal': [2882], 'Stat': [2885], 'Methods': [2886], 'Med': [2887], 'Res.': [2888], '13:': [2890], '17–48.CrossrefMedlineGoogle': [2891], 'Scholar17': [2892], 'Mehta': [2893], 'Yusuf': [2895], 'Peters': [2897], 'RJ,': [2898], 'Bertrand': [2899], 'ME,': [2900], 'Lewis': [2901], 'BS,': [2902], 'Natarajan': [2903], 'MK,': [2904], 'Malmberg': [2905], 'Rupprecht': [2907], 'Zhao': [2909], 'Chrolavicius': [2911], 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