Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2025204563', 'doi': 'https://doi.org/10.1253/jcj.63.759', 'title': 'Promoter Polymorphism of the &beta;<sub>2</sub> Bradykinin Receptor Gene is Associated With Essential Hypertension', 'display_name': 'Promoter Polymorphism of the &beta;<sub>2</sub> Bradykinin Receptor Gene is Associated With Essential Hypertension', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W2025204563', 'doi': 'https://doi.org/10.1253/jcj.63.759', 'mag': '2025204563', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10553917'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1253/jcj.63.759', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcj/63/10/63_10_759/_pdf', 'source': {'id': 'https://openalex.org/S2764682314', 'display_name': 'Japanese Circulation Journal', 'issn_l': '0047-1828', 'issn': ['0047-1828', '1347-4839'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313287', 'host_organization_name': 'Japanese Circulation Society', 'host_organization_lineage': ['https://openalex.org/P4310313287'], 'host_organization_lineage_names': ['Japanese Circulation Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jstage.jst.go.jp/article/jcj/63/10/63_10_759/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064507305', 'display_name': 'Shuji Mukae', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuji Mukae', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021491574', 'display_name': 'Shuichi Aoki', 'orcid': 'https://orcid.org/0000-0003-4221-0236'}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuichi Aoki', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025835758', 'display_name': 'Seiji Itoh', 'orcid': 'https://orcid.org/0009-0005-4430-7420'}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Seiji Itoh', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078553283', 'display_name': 'Kazuaki Nishio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuaki Nishio', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013793317', 'display_name': 'Toshiki Iwata', 'orcid': 'https://orcid.org/0000-0002-7738-3199'}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiki Iwata', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045368617', 'display_name': 'Hiroaki Ueda', 'orcid': 'https://orcid.org/0000-0001-8574-7290'}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Ueda', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048340159', 'display_name': 'Eiichi Geshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eiichi Geshi', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069864298', 'display_name': 'Tadao Fuzimaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tadao Fuzimaki', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101051267', 'display_name': 'Takashi Katagiri', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Katagiri', 'raw_affiliation_strings': ['Third Department of Internal Medicine, Showa University, School of Medicine.'], 'affiliations': [{'raw_affiliation_string': 'Third Department of Internal Medicine, Showa University, School of Medicine.', 'institution_ids': ['https://openalex.org/I119182057']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.772, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.804752, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '63', 'issue': '10', 'first_page': '759', 'last_page': '762'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13505', 'display_name': 'Apelin Signaling and Physiology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypertension', 'display_name': 'Hypertension', 'score': 0.533222}, {'id': 'https://openalex.org/keywords/b2-receptor', 'display_name': 'B2 receptor', 'score': 0.52774864}], 'concepts': [{'id': 'https://openalex.org/C2779591629', 'wikidata': 'https://www.wikidata.org/wiki/Q24745328', 'display_name': 'Bradykinin', 'level': 3, 'score': 0.74666625}, {'id': 'https://openalex.org/C3017940444', 'wikidata': 'https://www.wikidata.org/wiki/Q287961', 'display_name': 'B2 receptor', 'level': 4, 'score': 0.52774864}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5051964}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.4871106}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4740933}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42122465}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37206727}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36805338}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36575022}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3620892}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.35783947}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35663486}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3565659}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.117660135}], 'mesh': [{'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018002', 'descriptor_name': 'Receptors, Bradykinin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018002', 'descriptor_name': 'Receptors, Bradykinin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000483', 'descriptor_name': 'Alleles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005796', 'descriptor_name': 'Genes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005796', 'descriptor_name': 'Genes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018002', 'descriptor_name': 'Receptors, Bradykinin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1253/jcj.63.759', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcj/63/10/63_10_759/_pdf', 'source': {'id': 'https://openalex.org/S2764682314', 'display_name': 'Japanese Circulation Journal', 'issn_l': '0047-1828', 'issn': ['0047-1828', '1347-4839'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313287', 'host_organization_name': 'Japanese Circulation Society', 'host_organization_lineage': ['https://openalex.org/P4310313287'], 'host_organization_lineage_names': ['Japanese Circulation Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10553917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1253/jcj.63.759', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcj/63/10/63_10_759/_pdf', 'source': {'id': 'https://openalex.org/S2764682314', 'display_name': 'Japanese Circulation Journal', 'issn_l': '0047-1828', 'issn': ['0047-1828', '1347-4839'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313287', 'host_organization_name': 'Japanese Circulation Society', 'host_organization_lineage': ['https://openalex.org/P4310313287'], 'host_organization_lineage_names': ['Japanese Circulation Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.65, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1764686129', 'https://openalex.org/W1970427756', 'https://openalex.org/W1972792954', 'https://openalex.org/W1976274934', 'https://openalex.org/W1986597061', 'https://openalex.org/W1992280077', 'https://openalex.org/W2020580829', 'https://openalex.org/W2021311015', 'https://openalex.org/W2022028563', 'https://openalex.org/W2022318928', 'https://openalex.org/W2024841768', 'https://openalex.org/W2040437662', 'https://openalex.org/W2043600435', 'https://openalex.org/W2051618380', 'https://openalex.org/W2061430800', 'https://openalex.org/W2066160129', 'https://openalex.org/W2072262664', 'https://openalex.org/W2079585262', 'https://openalex.org/W2084825450', 'https://openalex.org/W2094445867', 'https://openalex.org/W2105429058', 'https://openalex.org/W2110303164', 'https://openalex.org/W2123696429', 'https://openalex.org/W2130501592', 'https://openalex.org/W2151458434', 'https://openalex.org/W2160406258', 'https://openalex.org/W2180931296', 'https://openalex.org/W2318650522', 'https://openalex.org/W2338539226', 'https://openalex.org/W2416890084', 'https://openalex.org/W2467296907', 'https://openalex.org/W3104001759', 'https://openalex.org/W3199891410', 'https://openalex.org/W4251679311', 'https://openalex.org/W4256002744'], 'related_works': ['https://openalex.org/W4376253866', 'https://openalex.org/W3202327181', 'https://openalex.org/W2973655474', 'https://openalex.org/W2477226648', 'https://openalex.org/W2416505715', 'https://openalex.org/W2092178108', 'https://openalex.org/W2015489274', 'https://openalex.org/W1995080546', 'https://openalex.org/W1975811142', 'https://openalex.org/W132325605'], 'abstract_inverted_index': {'The': [0, 38, 51, 84], 'present': [1], 'study': [2, 39], 'examined': [3], 'the': [4, 8, 26, 57, 63, 72, 78, 101, 110, 136, 156, 160, 175], 'genetic': [5, 150], 'contribution': [6], 'of': [7, 25, 41, 159], 'human': [9, 119, 161], 'β2': [10, 111, 162], 'bradykinin': [11, 112, 163], 'receptor': [12, 113, 164], 'gene': [13, 114, 165], 'in': [14, 36, 66, 81, 88, 100, 122, 174], 'Japanese': [15, 176], 'subjects': [16, 44, 97], 'with': [17, 118, 149], 'essential': [18, 34, 120, 172], 'hypertension,': [19, 145], 'and': [20, 45, 48, 60, 69, 75, 95, 105, 109, 146], 'identified': [21], 'a': [22, 131], '-58T/C': [23], 'polymorphism': [24, 158], 'core': [27], 'promoter': [28], 'that': [29, 155], 'might': [30], 'be': [31], 'responsible': [32], 'for': [33, 56, 62, 71, 77, 134, 138, 171], 'hypertension': [35, 121, 173], 'Japanese.': [37], 'consisted': [40], '100': [42, 46], 'hypertensive': [43, 67, 94], 'age-': [47], 'sex-matched': [49], 'controls.': [50], 'allelic': [52, 85, 106], 'frequencies': [53, 86, 107], 'were': [54, 87, 98], '0.575': [55], 'C': [58, 73], 'allele': [59, 65, 74, 80], '0.425': [61], 'T': [64, 79], 'subjects,': [68], '0.465': [70], '0.535': [76], 'normotensive': [82, 96], 'subjects.': [83], 'Hardy-Weinberg': [89], 'equilibrium.': [90], 'Significant': [91], 'differences': [92], 'between': [93], 'seen': [99], 'genotypes': [102], 'distribution': [103], '(p=0.049)': [104], '(p=0.028),': [108], 'variant': [115], 'was': [116], 'associated': [117], 'this': [123], 'Japanense': [124], 'population.': [125, 177], 'This': [126], 'new': [127], 'marker': [128], 'may': [129], 'provide': [130], 'valuable': [132], 'tool': [133], 'assessing': [135], 'risk': [137, 169], 'putative': [139], 'bradykinin-associated': [140], 'common': [141], 'diseases,': [142], 'such': [143], 'as': [144], 'cardiovascular': [147], 'diseases': [148], 'determinism.': [151], 'These': [152], 'results': [153], 'suggest': [154], '-58': [157], 'is': [166], 'an': [167], 'independent': [168], 'factor': [170], '(Jpn': [178], 'Circ': [179], 'J': [180], '1999;': [181], '63:': [182], '759': [183], '-': [184], '762)': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2025204563', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-12T23:46:01.168580', 'created_date': '2016-06-24'}