Publication Information

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574], 'a': [46, 120, 216, 251, 291, 391, 409, 444, 454, 461, 502, 508, 521, 564, 575, 719, 739, 766, 780], 'complete': [47, 503, 576], 'cytogenetic': [48, 504, 577], 'response': [49, 578, 678, 784], '(CCRe)': [50], 'following': [51, 258, 298, 328, 367, 411, 602, 751], 'treatment.': [53, 372, 399, 413, 581, 590, 811], 'Prognostic': [54], 'scoring': [55], 'methods,': [56], 'such': [57, 630], 'as': [58, 119, 631, 779], 'the': [59, 64, 160, 178, 417, 425, 596, 599, 613, 657, 677, 704, 733, 746, 757, 818, 844, 848, 854, 875], 'Sokal': [60, 638], 'score,': [61], 'activity': [62, 127, 136, 558, 688, 707, 737], 'uptake': [66], 'transporter,': [67], 'hOCT1': [68, 641], '(human': [69], 'organic': [70], 'cation': [71], 'transporter': [72], '1)': [73], '(Wang': [74], 'and': [78, 194, 226, 230, 247, 256, 339, 345, 353, 378, 386, 424, 460, 621, 640, 650, 828, 834, 841, 846, 851, 861, 869], 'BCR-ABL1': [79, 124, 133, 432, 540, 555, 685, 722, 734], 'transcript': [80], 'type': [81], '(Lucas': [82], '2009)': [85, 649], 'have': [86, 563], 'been': [87, 117], 'shown': [88, 220], 'correlate': [90, 279], 'with': [91, 172, 262, 280, 290, 390, 453, 507, 518, 553, 588, 753, 775], 'clinical': [92, 173, 281, 346, 365, 379, 628, 665, 770, 871], 'outcome.': [93, 174, 347], 'However,': [94], 'none': [95], 'these': [97], 'parameters': [98, 629], 'are': [99], 'sufficiently': [100], 'powerful': [101], 'reliably': [103], 'predict': [105], 'destined': [107], 'fare': [109], 'poorly.': [110], 'The': [111, 449, 812, 878], 'phosphorylation': [112, 164], 'status': [113], 'CrkL': [115, 163], 'identified': [118], 'surrogate': [121], 'marker': [122], 'tyrosine': [125, 134, 420, 541, 556, 686, 735, 786], 'kinase': [126, 135, 421, 433, 542, 557, 687, 706, 723, 736, 787], '(White': [128], '2005),': [131], 'because': [132, 535], 'cannot': [137], 'reliability': [139], 'detected': [140, 437], 'CML': [142, 254, 361, 850], 'patient': [143, 184, 217, 255, 318, 867], 'samples': [144, 868], '(Patel': [145], '2007).': [148], 'White': [149], 'al': [151], '(2005)': [152], 'showed,': [153], 'by': [154, 233, 364, 446], 'Western': [155, 189], 'blotting,': [156, 190], 'changes': [158, 257], 'level': [161, 342], 'after': [165], '1': [166], 'month': [167], 'treatment': [170, 261, 303, 333, 478, 499, 606, 752, 764], 'correlated': [171], 'Flow': [175], 'cytometry': [176], 'advantage': [179], 'it': [181, 797], 'requires': [182], 'fewer': [183], 'cells': [185, 807], '(∼103': [186], 'cells)': [187], 'produces': [191], 'quantitative': [192], 'values,': [193], 'results': [195], 'can': [196], 'obtained': [198], 'rapidly.': [199], 'Additionally': [200], 'this': [201, 472, 801, 837, 858], 'methodology': [202], 'could': [203], 'utilized': [205], 'easily': [207], 'at': [208, 343, 376, 381, 479, 486, 636, 690], 'other': [209, 426, 627], 'laboratories.': [210], 'A': [211, 692], 'representative': [212], 'FACS': [213, 243, 348], 'histogram': [214], 'sample': [218], 'is': [219, 533, 537, 660, 672, 682, 715, 765, 798, 802], 'Fig': [222, 493], '1.': [223], 'Patient': [224], 'characteristics': [225], 'optimization': [227], 'pCrKL': [229, 246, 351], 'CrKL': [231, 248, 338], 'detection': [232], 'flow': [234], 'cytometry.': [235], '(A)': [236, 352], 'Summary': [237], 'characteristics.': [240], '(B)': [241, 356], 'Representative': [242], 'plot': [244], 'showing': [245], '(C)': [249, 373], 'newly': [252, 359], 'diagnosed': [253, 360], 'vitro': [260], '5': [263], 'μmol/l': [264], 'for': [266, 384, 618, 667, 831, 857, 865], '24': [267], 'h.': [268], 'Our': [269], 'study': [270, 473, 845], 'demonstrated': [271], 'measuring': [273], 'pCrkL': [274], 'levels': [275], 'alone': [276], 'did': [277], 'not': [278], 'outcome': [282, 366, 380, 666, 771], '(Fig': [283, 304], '2A).': [284], 'Hundred': [285], 'per': [286], 'cent': [287], 'pre-treatment': [292], 'pCrkL/CrkL': [293, 320, 456, 483, 509, 600, 615, 658, 709, 758], 'ratio': [294, 321, 341, 355, 375, 393, 457, 511, 561, 601, 616, 659, 710, 759], '<25': [295], 'achieved': [296, 311, 326, 501, 520], 'CCRe': [297, 313, 327, 410, 445, 522, 587, 750], '12': [299, 329, 368, 382, 447, 496], 'months': [300, 330, 369, 383, 497], '2B).': [305], 'Of': [306], 'these,': [307], '75%': [308], 'their': [312, 832], 'within': [314], '6': [315], 'months.': [316, 448], 'No': [317, 431], 'whose': [319], 'was': [322, 874], 'greater': [323, 512, 740], '25': [325, 395, 459, 514], '(P': [334, 529], '=': [335, 530], '0·0003).': [336], 'pCrKL,': [337], 'pCrKL/CrKL': [340, 354, 374, 392], 'diagnosis': [344, 377, 487], 'assessment': [349], 'untreated': [358], 'patients,': [362, 452], 'stratified': [363], 'imatinib-': [385, 620], 'nilotinib-treated': [387, 583, 622], 'patients.': [388, 670], 'Patients': [389, 506], 'below': [394, 458], 'responded': [396], 'Six': [400], 'out': [401], '14': [403], 'imatinib-treated': [404, 527, 643], 'failed': [406, 441], 'Three': [414], 'switched': [415], 'second': [418], 'generation': [419], 'inhibitor': [422, 543, 724, 788], 'nilotinib': [423, 477, 519, 536, 580], 'three': [427], 'remain': [428, 468], 'on': [429, 579, 804], 'imatinib.': [430, 776], 'domain': [434], 'mutations': [435], 'were': [436, 516, 863], 'who': [440, 515], 'remaining': [450], 'eight': [451], 'diagnostic': [455, 614], 'maximum': [462], 'follow': [463], 'up': [464], '2': [466], 'years,': [467], 'CCRe.': [470], 'During': [471], 'six': [474], 'commenced': [476], 'initial': [480], 'diagnosis.': [481, 691], 'Their': [482], 'MFI': [484, 510, 560], 'ratios': [485], 'ranged': [488], 'from': [489], '7·5': [490], '47·3': [492], '2C.': [494], 'Following': [495], 'all': [500], 'response.': [505], 'treated': [517, 669, 774], 'compared': [523], '0%': [525], '0·03).': [531], 'This': [532, 654, 743], 'probably': [534], 'potent': [539, 721, 767], "(O'Hare": [544], '2005).': [547], 'These': [548], 'data': [549, 617], 'high': [554], '(pCrkL/CrkL': [559], '>25)': [562], 'low': [565], 'probability': [566], 'responding': [568], 'imatinib,': [570], 'may': [572, 697, 731, 744], 'nevertheless': [573], 'All': [582], 'remained': [585], 'continued': [589], 'In': [591, 755], 'addition,': [592], 'serial': [593], 'monitoring': [594], 'trends': [597], 'commencement': [603, 762], 'had': [607], 'no': [608, 652, 881], 'predictive': [609, 781], 'value.': [610], 'We': [611], 'analysed': [612], 'both': [619], 'relation': [625], 'white': [632], 'blood': [633], 'cell': [634], 'count': [635], 'diagnosis,': [637], 'score': [639], '(for': [642], 'only),': [645], '(Davies': [646], 'found': [651], 'correlation.': [653], 'suggests': [655], 'an': [661], 'independent': [662], 'biomarker': [663, 782], 'interesting': [673], 'speculate': [675], 'related': [683], 'present': [689], 'fixed': [693], 'dose': [694], 'therefore': [698], 'only': [699], 'able': [701], 'suppress': [703, 732], 'lower': [705], 'i.e.': [708], '<25;': [711], 'while': [712], 'nilotinib,': [713], 'which': [714], 'known': [716], '(Kantarjian': [727], '2007),': [730], 'proportional': [741], 'extent.': [742], 'explain': [745], 'higher': [747], 'incidence': [748], 'nilotinib.': [754], 'conclusion,': [756], 'prior': [760, 808], 'predictor': [768], 'Its': [777], 'role': [778], 'merits': [790], 'further': [791], 'investigation': [792], 'larger': [794], 'series,': [795], 'though': [796], 'essential': [799], 'performed': [803, 853], 'freshly': [805], 'isolated': [806], 'any': [810], 'authors': [813, 879], 'like': [815], 'thank': [817], 'University': [819], 'Liverpool': [821], 'Biobank': [822], 'staff': [823], 'Joanna': [824], 'Middleton,': [825], 'Melanie': [826], 'Oates': [827], 'Alison': [829], 'Hayes': [830], 'help': [833], 'support': [835], 'during': [836], 'project.': [838], 'CML,': [839], 'RJH': [840], 'REC': [842, 873], 'designed': [843], 'wrote': [847], 'manuscript.': [849], 'AG': [852], 'laboratory': [855], 'work': [856], 'study.': [859], 'KK': [860], 'SW': [862], 'responsible': [864], 'taking': [866], 'providing': [870], 'information.': [872], 'principal': [876], 'investigator.': [877], 'reported': [880], 'potential': [882], 'conflicts': [883], 'interest.': [885]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024975901', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T08:16:35.449867', 'created_date': '2016-06-24'}