Publication Information

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2252, 2301, 2371, 2433, 2655, 2663, 2674, 2760, 2798, 2811, 2845, 2854, 2889, 2966, 2972, 3065, 3075, 3122, 3137, 3185, 3280, 3287, 3300, 3310, 3338, 3447, 3461, 3511, 3560, 3578, 3646, 3668, 3683, 3688, 3704, 3713, 3725, 3744, 3818, 3822, 3831, 3840, 3867, 3962, 4041, 4055, 4062, 4162, 4208, 4290, 4314, 4321, 4330, 4407, 4415, 4495, 4502, 4571, 4579, 4593, 4600, 4605, 4632, 4644, 4654, 4660, 4680, 4717, 4724, 4822, 4839, 4891], 'gene': [17, 203, 1317, 3204], 'expression.': [18, 204, 1878], 'All': [19, 205], 'these': [21, 207, 3507, 4554, 4601, 4664, 4820], 'processes': [22, 208], 'are': [23, 209, 908, 1272, 1340, 3423, 3749, 4053, 4362, 4699, 4749], 'known': [24, 210, 700, 1273, 2931, 3750], 'to': [25, 211, 400, 656, 763, 872, 903, 984, 996, 1006, 1064, 1127, 1274, 1322, 2120, 2237, 2399, 2424, 2567, 2585, 2612, 2651, 2741, 2754, 2963, 3029, 3190, 3284, 3473, 3542, 3547, 3653, 3751, 3762, 3834, 4087, 4179, 4419, 4488, 4557, 4568, 4673, 4677, 4697, 4703, 4747, 4832, 4834, 4860], 'be': [26, 212, 1007, 1065, 3752, 4088, 4186, 4486, 4850], 'further': [27, 131, 213, 317, 3411, 3677, 4167], 'increased': [28, 106, 132, 214, 292, 318, 3022, 3220, 3309, 3502, 3678, 4139, 4263, 4671, 4736], 'under': [29, 80, 125, 215, 266, 311, 1311, 1883, 2036, 2598, 2925, 3057, 4257, 4550, 4854], 'hypoxic': [30, 126, 216, 312, 1279, 2926, 3557, 4855], 'conditions.': [31, 217, 2601, 4552], 'activated': [33, 78, 91, 115, 128, 175, 219, 264, 277, 301, 314, 361, 1069, 2383, 3491, 3497, 3532, 3574, 3648, 3858, 4259, 4537, 4665, 4851], 'express': [35, 221, 4668], 'inducible': [36, 222, 866, 2861], '6-phosphofructo-2-kinase': [37, 57, 223, 243, 375, 380, 653], '(iPFK-2),': [38, 224], 'which': [39, 225, 558, 856, 972, 1116, 1331, 3138, 3563, 4083, 4269, 4667, 4836], 'synthesizes': [40, 226], 'fructose': [41, 107, 135, 227, 293, 321, 377, 720, 2666, 2819], '2,6-bisphosphate,': [42, 228], 'stimulator': [44, 230, 726], 'glycolysis.': [46, 111, 139, 232, 297, 325, 731], 'During': [47, 233], 'ischemia,': [48, 234], 'AMP-activated': [49, 235, 372, 405], 'protein': [50, 236, 373, 406, 453, 766, 3289, 3830, 3839, 4493, 4541], 'kinase': [51, 237, 374, 407, 4494], '(AMPK)': [52, 238, 2595], 'activates': [53, 239], 'the': [54, 66, 73, 86, 147, 155, 168, 178, 240, 252, 259, 272, 333, 341, 354, 364, 401, 404, 413, 602, 698, 707, 715, 723, 873, 997, 1110, 1130, 1136, 1143, 1350, 1582, 1614, 1750, 1832, 1842, 1865, 1884, 1887, 1893, 1898, 1903, 1968, 2037, 2041, 2091, 2132, 2205, 2247, 2253, 2346, 2387, 2400, 2417, 2422, 2426, 2477, 2482, 2487, 2514, 2524, 2546, 2565, 2571, 2586, 2599, 2629, 2681, 2728, 2743, 2747, 2756, 2778, 2869, 2910, 2943, 3013, 3076, 3198, 3201, 3211, 3353, 3359, 3380, 3408, 3424, 3603, 3609, 3618, 3679, 3702, 3711, 3721, 3726, 3732, 3764, 3769, 3814, 3888, 3901, 3905, 3915, 4002, 4009, 4022, 4036, 4056, 4073, 4133, 4157, 4170, 4193, 4204, 4272, 4277, 4302, 4310, 4326, 4359, 4394, 4411, 4496, 4506, 4545, 4594, 4614, 4639, 4685, 4689, 4692, 4718, 4816, 4862, 4893], 'homologous': [55, 87, 241, 273, 902], 'heart': [56, 242, 652, 904, 989, 1622, 2684, 2737, 2751, 2784, 2863, 3770, 4081, 4131, 4197], 'isoform': [58, 244, 877, 4079], 'by': [59, 92, 100, 162, 172, 184, 245, 278, 286, 348, 358, 370, 704, 748, 765, 859, 910, 980, 1009, 1070, 1315, 1320, 1330, 1336, 1356, 1603, 1759, 1839, 1871, 2345, 2384, 2545, 2561, 2574, 2606, 2635, 2686, 2866, 3182, 3240, 3291, 3533, 3649, 3730, 3909, 4013, 4060, 4137, 4169, 4212, 4287, 4538, 4576, 4598, 4751, 4852], 'phosphorylating': [60, 246], 'its': [61, 247, 657, 3912, 4148], 'Ser-466.': [62, 248], 'Here,': [63, 249], 'we': [64, 250, 4636], 'studied': [65, 251], 'involvement': [67, 253, 3722], 'AMPK': [69, 129, 152, 255, 315, 338, 449, 597, 648, 981, 1010, 1357, 1449, 1474, 1630, 2258, 2607, 2649, 2687, 2768, 2776, 2867, 2879, 2957, 3019, 3049, 3120, 3321, 3329, 3394, 3492, 3561, 3597, 3724, 3739, 3767, 3861, 3907, 3961, 4007, 4019, 4034, 4050, 4092, 4138, 4213, 4260, 4289, 4299, 4853], 'iPFK-2': [71, 82, 103, 133, 161, 183, 257, 268, 289, 319, 347, 369, 869, 969, 1002, 1048, 1355, 1365, 1405, 1620, 1693, 2126, 2603, 2733, 2772, 2782, 3178, 3218, 3281, 3288, 3301, 3475, 3729, 3815, 3847, 3865, 3896, 4012, 4029, 4040, 4052, 4136, 4184, 4209, 4283, 4308, 4532, 4609, 4847, 4872], 'glycolysis': [76, 171, 262, 357, 703, 1220, 1324, 1332, 3337, 4059, 4313, 4329, 4559, 4597, 4734], 'hypoxia.': [81, 267, 1359, 3058], 'was': [83, 269, 857, 863, 1003, 1395, 1406, 1450, 1694, 1867, 1900, 1965, 1996, 2103, 2174, 2202, 2234, 2313, 2343, 2449, 2474, 2484, 2543, 2604, 2876, 2959, 3051, 3062, 3180, 3405, 3470, 3519, 3564, 3588, 3638, 3644, 3666, 3742, 4084, 4177, 4210, 4320, 4334, 4469, 4504, 4533, 4560, 4586, 4590, 4610, 4618, 4625, 4650], 'phosphorylated': [84, 270, 1008, 2605, 2748, 2769, 2865, 4194, 4211, 4535], 'on': [85, 271, 2777, 3048, 3119, 3320, 3328, 3607, 3768, 3879, 4008, 4715, 4733], 'serine': [88, 274], '(Ser-461)': [89, 275], 'AMPKin': [93, 279], 'vitro.': [94, 280], 'human': [98, 142, 284, 328, 383, 1054, 1439, 1762, 3133, 4412, 4606, 4705], 'lipopolysaccharide': [101, 287, 382, 1071], 'induced': [102, 288, 858, 1066, 3071, 4072], 'expression': [104, 148, 290, 334, 1318, 3179, 3199, 3231, 4074], '2,6-bisphosphate': [108, 136, 294, 322, 378, 721], 'content': [109, 295, 3391, 3476, 3715, 3825, 4573], 'incubation': [113, 299, 3014, 3024, 3377, 3400, 3468, 3483, 3539, 4066, 4250], 'with': [117, 303, 1445, 1626, 1696, 1787, 1851, 1967, 1987, 2112, 2131, 2204, 2393, 2550, 2608, 2641, 2648, 2659, 2763, 2800, 2813, 2847, 2868, 2878, 2909, 2929, 3025, 3193, 3197, 3293, 3369, 3378, 3401, 3489, 3524, 3569, 3593, 3656, 3672, 3710, 3754, 3813, 3843, 3853, 3887, 4070, 4130, 4254, 4294, 4365], 'oligomycin,': [118, 304, 3379, 3402, 3731], 'an': [119, 305, 410, 1120, 2511, 2520, 2951, 3285, 3294, 3538, 3615, 4189, 4473], 'inhibitor': [120, 306, 2952], 'oxidative': [122, 308, 394, 2954], 'phosphorylation,': [123, 309, 1692], 'or': [124, 310, 1850, 1953, 2592, 2668, 2928, 2947, 2970, 3027, 3346, 3368, 3530, 3549, 3657, 4256], 'conditions': [127, 313, 1314, 1885, 2038, 2097, 2927], 'activity,': [134, 320, 3332], 'content,': [137, 323, 3335], 'In': [140, 326, 3551, 3884, 4553, 4663], 'cultured': [141, 327, 1774, 1980, 2094, 2370], 'embryonic': [143, 329, 384, 1440, 3134], 'kidney': [144, 330, 385, 1441, 3135], '293': [145, 331], 'cells,': [146, 332, 4472], 'dominant-negative': [151, 337, 381, 1472, 3736, 3902, 4006, 4288], 'prevented': [153, 339], 'both': [154, 340, 3859, 3919, 4021], 'phosphorylation': [158, 179, 344, 365, 395, 764, 979, 1351, 2622, 2632, 2639, 2682, 2757, 3894, 4023, 4134, 4154, 4176, 4182, 4279, 4304], 'co-transfected': [160, 346, 4293], 'oligomycin.': [163, 349, 3374, 3527, 3550, 4014], 'It': [164, 350, 533, 3495], 'is': [165, 351, 450, 534, 598, 710, 870, 901, 921, 1049, 1213, 1333, 1747, 3707, 4166], 'concluded': [166, 352, 4587], 'that': [167, 353, 562, 607, 647, 923, 957, 985, 2118, 2767, 2964, 3055, 3525, 3591, 3701, 3911, 4033, 4049, 4153, 4172, 4531, 4588, 4624, 4630, 4638, 4744, 4828], 'hypoxia': [173, 359, 390, 1339, 3028, 3518, 3548, 4061, 4258, 4599, 4670, 4698, 4714, 4727, 4748], 'requires': [177, 363], 'AMPK.': [185, 371, 1703, 2851], '6-P2,': [376], 'Inducible': [379], 'interleukin': [386, 2121], 'Energy': [387], 'deprivation': [388], '(e.g.': [389], 'inhibitors': [392], 'such': [396, 1312, 4753], 'as': [397, 536, 961, 1452, 1709, 1869, 2315, 2496, 2554, 3126, 3207, 3237, 3567, 4400, 4754], 'oligomycin)': [398], 'leads': [399], '(AMPK)1': [408], 'via': [409], 'increase': [411, 2654, 3074, 3279, 3286, 3703, 3712, 3821], 'AMP:ATP': [414, 3077], 'ratio': [415, 3078], '(for': [416, 768], 'review': [417, 769], 'see': [418, 770], 'Refs.': [419, 771], '1Hardie': [420], 'D.G.': [421, 437, 542, 570, 585, 1458, 1590, 2262], 'Carling': [422, 515, 543, 571, 675, 1029, 1487, 1518, 1587, 1931, 2069, 2706, 2990, 3095, 3159, 3789, 3939, 3981, 4109, 4230], 'D.': [423, 466, 516, 544, 572, 676, 1030, 1456, 1488, 1519, 1588, 1637, 1670, 1715, 1932, 2070, 2260, 2279, 2707, 2991, 3096, 3160, 3790, 3940, 3982, 4110, 4231, 4874], 'Eur.': [424, 573, 1591, 2327], 'J.': [425, 472, 487, 512, 517, 574, 637, 666, 777, 819, 890, 1020, 1074, 1172, 1195, 1230, 1241, 1286, 1381, 1413, 1422, 1490, 1509, 1540, 1592, 1635, 1644, 1677, 1713, 1722, 1794, 1922, 2007, 2016, 2060, 2137, 2286, 2328, 2461, 2697, 2981, 3086, 3150, 3245, 3780, 3930, 3972, 4100, 4221, 4342, 4377, 4425, 4514, 4766, 4783, 4804], 'Biochem.': [426, 549, 575, 776, 800, 891, 941, 1258, 1489, 1593, 2329, 2356, 2460, 2530, 3626], '1997;': [427, 576, 1647, 1725], '246:': [428, 577], '259-273Crossref': [429, 578], 'PubMed': [430, 444, 498, 528, 553, 579, 592, 624, 689, 781, 810, 847, 895, 951, 1043, 1102, 1160, 1177, 1206, 1247, 1262, 1390, 1433, 1465, 1494, 1532, 1568, 1655, 1686, 1733, 1822, 1945, 2027, 2083, 2165, 2269, 2295, 2333, 2363, 2465, 2537, 2720, 3004, 3109, 3173, 3273, 3633, 3803, 3953, 3995, 4123, 4244, 4353, 4388, 4453, 4525, 4771, 4791, 4810], 'Scopus': [431, 445, 499, 529, 554, 580, 593, 625, 690, 782, 811, 848, 896, 952, 1044, 1103, 1161, 1178, 1248, 1263, 1391, 1434, 1466, 1495, 1533, 1569, 1597, 1656, 1734, 1823, 1946, 2028, 2084, 2166, 2270, 2334, 2364, 2466, 2538, 2721, 3005, 3110, 3174, 3274, 3634, 3804, 3954, 3996, 4124, 4245, 4354, 4389, 4454, 4526, 4772, 4792, 4811], '(1141)': [432, 581], 'Google': [433, 447, 501, 531, 556, 582, 595, 627, 642, 692, 784, 813, 850, 898, 954, 1046, 1105, 1163, 1180, 1207, 1235, 1250, 1265, 1291, 1393, 1436, 1468, 1497, 1535, 1571, 1599, 1658, 1687, 1736, 1825, 1948, 2030, 2086, 2168, 2272, 2296, 2336, 2366, 2468, 2540, 2723, 3007, 3112, 3176, 3276, 3636, 3806, 3956, 3998, 4126, 4247, 4356, 4391, 4456, 4528, 4774, 4794, 4813], 'Scholar': [434, 785], '2Hardie': [436, 584], 'Hawley': [438, 586], 'S.A.': [439, 587], 'Bioessays.': [440, 588], '2001;': [441, 589, 802, 943, 4345, 4380, 4517], '23:': [442, 590], '1112-1119Crossref': [443, 591], '(676)': [446, 594], 'Scholar).': [448, 532, 596, 643, 693, 814, 1047, 1208, 1266, 1307, 1469, 1498, 1688, 1737, 1826, 2031, 2087, 2169, 2337, 2367, 2469, 2541, 2724, 3113, 3177, 3277, 3807, 3999, 4127, 4248], 'heterotrimeric': [452], 'composed': [454], 'catalytic': [457, 745], '(α)': [458], 'two': [460, 2930], 'regulatory': [461, 753, 966], '(β,': [462], 'γ)': [463], 'subunits': [464], '(3Stapleton': [465], 'Mitchelhill': [467], 'K.I.': [468], 'Gao': [469], 'G.': [470, 674, 1028, 1168, 1284, 1517, 1672, 1930, 2068, 2281, 2705, 2989, 3094, 3158, 3788, 3938, 3980, 4108, 4229], 'Widmer': [471], 'Michell': [473], 'B.J.': [474], 'Teh': [475], 'T.': [476, 482, 1183, 1197, 1199, 4337, 4372, 4509], 'House': [477], 'C.M.': [478], 'Fernandez': [479], 'C.S.': [480], 'Cox': [481], 'Witters': [483], 'L.A.': [484], 'Kemp': [485], 'B.E.': [486], 'Biol.': [488, 518, 680, 1034, 1423, 1523, 1645, 1678, 1723, 1936, 2017, 2074, 2287, 2711, 2995, 3100, 3164, 3794, 3944, 3986, 4114, 4235, 4343, 4378, 4515, 4787], 'Chem.': [489, 519, 1424, 1646, 1679, 1724, 2018, 2288, 4344, 4379, 4516], '1996;': [490, 520, 892, 4788], '271:': [491, 521], '611-614Abstract': [492], 'Full': [493, 495, 523, 525, 684, 686, 805, 807, 946, 948, 1038, 1040, 1428, 1430, 1527, 1529, 1650, 1652, 1683, 1728, 1730, 1940, 1942, 2022, 2024, 2078, 2080, 2292, 2715, 2717, 2999, 3001, 3104, 3106, 3168, 3170, 3798, 3800, 3948, 3950, 3990, 3992, 4118, 4120, 4239, 4241, 4348, 4350, 4383, 4385, 4520, 4522], 'Text': [494, 496, 524, 526, 685, 687, 806, 808, 947, 949, 1039, 1041, 1429, 1431, 1528, 1530, 1651, 1653, 1684, 1729, 1731, 1941, 1943, 2023, 2025, 2079, 2081, 2293, 2716, 2718, 3000, 3002, 3105, 3107, 3169, 3171, 3799, 3801, 3949, 3951, 3991, 3993, 4119, 4121, 4240, 4242, 4349, 4351, 4384, 4386, 4521, 4523], 'PDF': [497, 527, 688, 809, 950, 1042, 1432, 1531, 1654, 1685, 1732, 1944, 2026, 2082, 2294, 2719, 3003, 3108, 3172, 3802, 3952, 3994, 4122, 4243, 4352, 4387, 4524], '(564)': [500], 'Scholar,': [502, 583, 1164, 1181, 1236, 1251, 1292, 4775, 4795], '4Woods': [503], 'A.': [504, 790, 792, 843, 879, 931, 933, 1098, 1255, 1367, 1482, 1564, 1818, 2161, 3269, 4449], 'Cheung': [505], 'P.C.F.': [506], 'Smith': [507], 'F.C.': [508], 'Davison': [509, 1485], 'M.D.': [510, 1486], 'Scott': [511], 'Beri': [513], 'R.K.': [514], '10282-10290Abstract': [522], '(218)': [530], 'considered': [535], '"metabolic': [538], 'master': [539], 'switch"': [540], '(5Hardie': [541], 'Carlson': [545], 'M.': [546, 825, 881, 883, 885, 1080, 1375, 1415, 1417, 1546, 1800, 2009, 2011, 2143, 3251, 4431, 4886], 'Annu.': [547], 'Rev.': [548], '1998;': [550, 1259, 1387], '67:': [551], '821-855Crossref': [552], '(1276)': [555], 'Scholar),': [557, 955, 1106, 1659, 3637, 4357, 4457], 'inactivates': [559], 'key': [560], 'targets': [561], 'control': [563, 3209, 4327], 'anabolic': [564], 'pathways,': [565], 'thereby': [566, 4857], 'conserving': [567], 'ATP': [568, 1326, 4859], '(1Hardie': [569], 'also': [599, 1061, 3496, 3520, 3573, 4884], 'implicated': [600, 4054], 'glucose': [605, 2381, 2453, 2499, 3404, 3419, 3664], 'uptake': [606], 'occurs': [608, 4155, 4838], 'contracting': [610], 'muscle': [611], '(6Kurth-Kraczek': [612], 'E.J.': [613], 'Hirshman': [614], 'M.F.': [615, 670, 1024, 1513, 1926, 2064, 2701, 2985, 3090, 3154, 3784, 3934, 3976, 4104, 4225], 'Goodyear': [616], 'L.J.': [617], 'Winder': [618], 'W.W.': [619], 'Diabetes.': [620], '1999;': [621, 639, 844, 1099, 1425, 1565, 1819, 2019, 2162, 3270, 4450], '48:': [622], '1667-1671Crossref': [623], '(587)': [626], 'Scholar,7Russell': [628], 'A.R.': [629], 'Bergeron': [630], 'R.': [631, 796, 821, 836, 889, 937, 1076, 1091, 1383, 1400, 1542, 1557, 1796, 1811, 2139, 2154, 2324, 3247, 3262, 4427, 4442, 4867], 'Shulman': [632], 'G.I.': [633], 'Young': [634], 'L.H.': [635, 1421, 2015], 'Am.': [636, 1229, 1285, 4782], 'Physiol.': [638, 1231, 1243, 1257], '277:': [640], 'H643-H649PubMed': [641], 'We': [644, 1343, 3898, 4000, 4826, 4865, 4883], 'showed': [645, 2766], 'previously': [646, 874, 1454, 1478, 1711, 2135, 2317, 3127, 3761, 3899, 4085], 'phosphorylates': [649], 'Ser-466': [650, 987, 2735, 2749, 4195], '(PFK-2),': [654], 'leading': [655, 4567], '(8Marsin': [659, 1013, 1502, 1915, 2053, 2690, 2974, 3079, 3143, 3773, 3923, 3965, 4093, 4214], 'A.-S.': [660, 1014, 1503, 1916, 2054, 2691, 2975, 3080, 3144, 3774, 3924, 3966, 4094, 4215], 'Bertrand': [661, 1015, 1504, 1917, 2055, 2692, 2976, 3081, 3145, 3775, 3925, 3967, 4095, 4216], 'L.': [662, 678, 773, 794, 935, 1016, 1032, 1409, 1505, 1521, 1641, 1674, 1719, 1918, 1934, 2003, 2056, 2072, 2283, 2353, 2457, 2527, 2693, 2709, 2977, 2993, 3082, 3098, 3146, 3162, 3623, 3776, 3792, 3926, 3942, 3968, 3984, 4096, 4112, 4217, 4233], 'Rider': [663, 774, 1017, 1418, 1506, 1642, 1675, 1720, 1919, 2012, 2057, 2284, 2694, 2978, 3083, 3147, 3777, 3927, 3969, 4097, 4218, 4888], 'M.H.': [664, 775, 1018, 1419, 1507, 1643, 1676, 1721, 1920, 2013, 2058, 2285, 2695, 2979, 3084, 3148, 3778, 3928, 3970, 4098, 4219, 4761], 'Deprez': [665, 1019, 1412, 1508, 1921, 2006, 2059, 2696, 2980, 3085, 3149, 3779, 3929, 3971, 4099, 4220], 'Beauloye': [667, 1021, 1510, 1923, 2061, 2698, 2982, 3087, 3151, 3781, 3931, 3973, 4101, 4222, 4880], 'C.': [668, 834, 1022, 1089, 1511, 1555, 1809, 1924, 2062, 2152, 2699, 2983, 3088, 3152, 3260, 3782, 3932, 3974, 4102, 4223, 4440, 4879], 'Vincent': [669, 1023, 1512, 1925, 2063, 2700, 2984, 3089, 3153, 3783, 3933, 3975, 4103, 4224], 'Van': [671, 1025, 1514, 1927, 2065, 2702, 2986, 3091, 3155, 3785, 3935, 3977, 4105, 4226], 'den': [672, 1026, 1515, 1928, 2066, 2703, 2987, 3092, 3156, 3786, 3936, 3978, 4106, 4227], 'Berghe': [673, 1027, 1516, 1929, 2067, 2704, 2988, 3093, 3157, 3787, 3937, 3979, 4107, 4228], 'Hue': [677, 1031, 1420, 1520, 1640, 1673, 1718, 1933, 2014, 2071, 2282, 2456, 2708, 2992, 3097, 3161, 3791, 3941, 3983, 4111, 4232], 'Curr.': [679, 1033, 1522, 1935, 2073, 2710, 2994, 3099, 3163, 3793, 3943, 3985, 4113, 4234], '2000;': [681, 1035, 1203, 1491, 1524, 1937, 2075, 2712, 2996, 3101, 3165, 3795, 3945, 3987, 4115, 4236], '10:': [682, 1036, 1525, 1938, 2076, 2713, 2997, 3102, 3166, 3796, 3946, 3988, 4116, 4237], '1247-1255Abstract': [683, 1037, 1526, 1939, 2077, 2714, 2998, 3103, 3167, 3797, 3947, 3989, 4117, 4238], '(636)': [691, 1045, 1534, 1947, 2085, 2722, 3006, 3111, 3175, 3805, 3955, 3997, 4125, 4246], 'This': [694, 1058, 2507, 3467, 4150, 4164, 4480], 'phenomenon': [695], 'participates': [696], 'well': [699], 'ischemia': [705], 'heart.': [708], 'PFK-2/fructose-2,6-bisphosphatase': [709, 735, 913], 'bifunctional': [712], 'enzyme': [713, 1951, 2582, 2619], 'catalyzing': [714], 'synthesis': [716], 'degradation': [718], '(Fru-2,6-P2),': [722], 'most': [724], '6-phosphofructo-1-kinase': [728], 'hence': [730], 'Tissue-specific': [732], 'isozymes': [733, 907], 'have': [736, 3758, 4709], 'been': [737, 1062, 3759], 'identified': [738], 'mammals.': [740], 'They': [741], 'possess': [742], 'conserved': [744], 'core': [746], 'flanked': [747], 'variable': [749], 'N-': [750], 'C-terminal': [752, 965], 'domains,': [754], 'they': [756, 958], 'differ': [757, 4406], 'tissue': [759], 'distribution': [760], 'response': [762, 1124, 3203, 4693], 'kinases': [767], '9Hue': [772], '1987;': [778], '245:': [779], '313-324Crossref': [780], '(334)': [783], '10Okar': [787], 'D.A.': [788, 929], 'Manzano': [789, 930], 'Navarro-Sabatè': [791, 932], 'Riera': [793, 934], 'Bartrons': [795, 936, 1382, 1401, 2323, 4868], 'Lange': [797, 938], 'A.J.': [798, 939], 'Trends': [799, 940], 'Sci.': [801, 840, 942, 1095, 1561, 1815, 2158, 3266, 4446], '26:': [803, 944], '30-35Abstract': [804, 945], '(272)': [812, 953], 'Chesney': [815, 3241], 'et': [816, 3242, 4369], 'al.': [817, 3243, 4370], '(11Chesney': [818, 1073, 1539, 1793, 2136, 3244, 4424], 'Mitchell': [820, 1075, 1541, 1795, 2138, 3246, 4426], 'Benigni': [822, 1077, 1543, 1797, 2140, 3248, 4428], 'F.': [823, 1078, 1371, 1544, 1798, 2141, 2455, 3249, 4429], 'Bacher': [824, 1079, 1545, 1799, 2142, 3250, 4430], 'Spiegel': [826, 1081, 1547, 1801, 2144, 3252, 4432], 'L.,': [827, 1082, 1548, 1802, 2145, 3253, 4433], 'Al-': [828, 1083, 1549, 1803, 2146, 3254, 4434], 'Abed': [829, 1084, 1550, 1804, 2147, 3255, 4435], 'Y.': [830, 1085, 1551, 1805, 2148, 3256, 4436], 'Han': [831, 1086, 1552, 1806, 2149, 3257, 4437], 'J.H.': [832, 1087, 1553, 1807, 2150, 3258, 4438], 'Metz': [833, 1088, 1554, 1808, 2151, 3259, 4439], 'Bucala': [835, 1090, 1556, 1810, 2153, 3261, 4441], 'Proc.': [837, 1092, 1558, 1812, 2155, 3263, 4443], 'Natl.': [838, 1093, 1559, 1813, 2156, 3264, 4444], 'Acad.': [839, 1094, 1560, 1814, 2157, 3265, 4445], 'U.': [841, 1096, 1238, 1562, 1816, 2159, 3267, 4447], 'S.': [842, 1097, 1189, 1379, 1563, 1817, 2160, 3268, 4448], '96:': [845, 1100, 1204, 1305, 1566, 1820, 2163, 3271, 4451], '3047-3052Crossref': [846, 1101, 1567, 1821, 2164, 3272, 4452], '(249)': [849, 1104, 1570, 1824, 2167, 3275, 4455], 'Scholar)': [851, 899, 1394, 1437, 1536, 1572, 1600, 1949, 2273, 2297, 3008, 3957, 4392, 4529, 4814], 'characterized': [852, 909], 'PFK-2': [854, 867, 919, 990, 1623, 1665, 2275, 2642, 2658, 2685, 2738, 2752, 2864, 2873, 3331, 3387, 3498, 3575, 3587, 3717, 3771, 3824, 3881, 4078, 4142, 4580], 'isozyme,': [855], 'proinflammatory': [860, 3212], 'stimuli': [861, 4821], 'therefore': [864], 'termed': [865], '(iPFK-2).': [868], 'identical': [871], 'described': [875, 1453, 1477, 1710, 2134, 2316], 'placental': [876], '(12Sakai': [878], 'Kato': [880], 'Fukasawa': [882], 'Ishiguro': [884], 'Furuya': [886], 'E.': [887, 1253, 2320], 'Sakakibara': [888], '119:': [893], '506-511Crossref': [894], '(54)': [897], 'PFK-2.': [905], 'These': [906, 1579, 2429, 2672, 3747, 4403], 'their': [911, 918, 925, 4464], 'relative': [912], 'activities.': [914], 'Under': [915], 'physiological': [916], 'conditions,': [917, 4856], 'activity': [920, 927, 2583, 2958, 3020, 3050, 3121, 3302, 3322, 3388, 3395], '>100-fold': [922], 'fructose-2,6-bisphosphatase': [926], '(10Okar': [928], 'indicating': [956, 2621], 'mainly': [959], 'act': [960], 'kinase.': [963], 'domain': [967], 'contains': [970], 'Ser-461,': [971], 'lies': [973], 'within': [974, 3221], 'favorable': [976], 'consensus': [977], 'for': [978, 1325, 1608, 1664, 1876, 1950, 1960, 2106, 2177, 2182, 2188, 2213, 2218, 2224, 2386, 2395, 2665, 2818, 2831, 2905, 3129, 3188, 3234, 3352, 3384, 3413, 3416, 3428, 3464, 3535, 3651, 3855, 4147, 4477, 4876, 4881, 4889], '(449KGPNPLMRRNSVTPLAS467),': [982], 'similar': [983, 2962, 4676], 'surrounding': [986, 999, 2730, 4206], '(455KSQTPVRMRRNSFTPLSS472).': [991], 'A': [992, 3661, 3691, 3872], 'synthetic': [993, 1577], 'peptide': [994, 1584, 4202], 'corresponding': [995], 'sequence': [998, 4205], 'Ser-461': [1000, 2731, 2759, 2770, 4161, 4207], 'indeed': [1004], 'shown': [1005, 1063, 4086, 4710], 'vitro': [1012], 'constitutively': [1050, 4460, 4534], 'expressed': [1051, 2495, 4846], 'several': [1053, 4408], 'cancer': [1055], 'cell': [1056, 1873, 4398], 'lines.': [1057], 'isozyme': [1059], 'has': [1060], '(LPS)': [1072], 'component': [1108], 'outer': [1111], 'membrane': [1112], 'Gram-negative': [1114], 'bacteria,': [1115], 'triggers': [1117], 'mimics': [1119], 'response.': [1122, 2241, 4864], 'LPS': [1128, 1337, 1855, 2385, 3194, 3316, 3534, 3650, 4071, 4740, 4755, 4829], 'includes': [1129], 'production': [1131], 'cytokines': [1133], 'chemokines,': [1135], 'arachidonic': [1139], 'acid': [1140], 'metabolites,': [1141], 'generation': [1144], 'reactive': [1146], 'oxygen': [1147], 'species': [1148], 'nitrogen': [1150], 'monoxide': [1151], '(13Bone': [1152], 'R.C.': [1153, 1240], 'Ann.': [1154], 'Intern.': [1155], 'Med.': [1156], '1991;': [1157, 1174], '115:': [1158], '457-469Crossref': [1159], '(1236)': [1162], '14Glauser': [1165], 'M.P.': [1166, 4765], 'Zanetti': [1167], 'Baumgartner': [1169], 'J.-D.': [1170], 'Cohen': [1171], 'Lancet.': [1173], '338:': [1175], '732-736Abstract': [1176], '(662)': [1179], '15Suzuki': [1182], 'Hashimoto': [1184], 'S.-I.': [1185], 'Toyoda': [1186], 'N.': [1187, 1191], 'Nagai': [1188], 'Yamazaki': [1190], 'Dong': [1192], 'H.-Y.': [1193], 'Sakai': [1194], 'Yamashita': [1196], 'Nukiwa': [1198], 'Matsushima': [1200], 'K.': [1201, 4341, 4376, 4513], 'Blood.': [1202], '2584-2591Crossref': [1205], 'Monocyte': [1209], 'consumes': [1211], 'energy,': [1212], 'glucose-dependent,': [1214], '(16Lang': [1221], 'C.H.': [1222], 'Bagby': [1223], 'G.J.': [1224], 'Fong': [1225], 'B.C.': [1226], 'Spitzer': [1227], 'J.J.': [1228], '1985;': [1232], '248:': [1233], 'R471-R478PubMed': [1234], '17Orlinska': [1237], 'Newton': [1239], 'Cell.': [1242, 1256], '1993;': [1244, 1680, 2289], '157:': [1245], '201-208Crossref': [1246], '(30)': [1249], '18Guida': [1252], 'Stewart': [1254], '8:': [1260], '75-88Crossref': [1261], '(34)': [1264], 'Moreover,': [1267, 3675], 'diseased': [1269, 4842], 'tissues,': [1270], 'accumulate': [1275, 3142], 'poorly': [1277], 'vascularized': [1278], 'sites': [1280], '(19Remensoyder': [1281], 'J.P.': [1282], 'Majno': [1283], 'Pathol.': [1287], '1968;': [1288], '52:': [1289], '301-316PubMed': [1290], '20Hunt': [1293], 'T.K.': [1294], 'Knighton': [1295], 'D.R.': [1296, 1411, 1639, 1717, 2005], 'Thackral': [1297], 'K.K.': [1298], 'Goodson': [1299], 'W.H.': [1300], 'Andrews': [1301], 'W.S.': [1302], 'Surgery.': [1303], '1983;': [1304], '48-54Google': [1306], 'Monocytes': [1308, 2368], 'remain': [1309], 'functional': [1310], 'adverse': [1313], 'altering': [1316], 'switching': [1321], 'anaerobic': [1323], 'production.': [1327], 'mechanisms': [1329], 'stimulated': [1334, 2634, 3187, 4267], 'synergistically': [1335], 'still': [1341], 'unknown.': [1342], 'tested': [1344, 3460], 'whether': [1345], 'this': [1346, 1446, 2764, 3556, 4005, 4318, 4583], 'synergism': [1347], 'results': [1348, 4045, 4360], 'from': [1349, 1438, 2421, 2451, 2486, 4410, 4688], 'construct': [1361, 3816, 3908], 'encoding': [1362], 'recombinant': [1363], 'polyhistidine-tagged': [1364], '(21Manzano': [1366], 'Rosa': [1368], 'J.L.': [1369], 'Ventura': [1370], 'Pérez': [1372], 'J.X.': [1373], 'Nadal': [1374], 'Estivill': [1376], 'X.': [1377], 'Ambrosio': [1378], 'Gil': [1380], 'Cytogenet.': [1384], 'Cell': [1385, 4785], 'Genet.': [1386], '83:': [1388], '214-217Crossref': [1389], '(65)': [1392], 'generous': [1397], 'gift': [1398], '(Barcelona,': [1402], 'Spain).': [1403], 'Recombinant': [1404], 'purified': [1407, 1451, 1619, 1741], '(22Bertrand': [1408, 2002], 'Alessi': [1410, 1638, 1716, 2004], 'Deak': [1414, 2008], 'Viaene': [1416, 2010], '274:': [1426, 2020], '30927-30933Abstract': [1427, 2021], '(59)': [1435, 2029], '(HEK)-293': [1442], 'cells': [1443, 1756, 1836, 1880, 1904, 1978, 2033, 2092, 2971, 3136, 3381, 3409, 3462, 3512, 3580, 3748, 3812, 3833, 3841, 3964, 4292, 4405, 4423, 4459, 4555, 4656], 'transfected': [1444, 3753, 3842, 3864, 3959], 'construct.': [1447], 'Liver': [1448], '(23Carling': [1455, 2259], 'Hardie': [1457, 1589, 2261], 'Biochim.': [1459, 2263], 'Biophys.': [1460, 2264, 2357, 2531, 3627], 'Acta.': [1461, 2265], '1989;': [1462, 1594, 2266], '1012:': [1463, 2267], '81-86Crossref': [1464, 2268], '(258)': [1467, 2271], 'Wild-type': [1470], 'α1': [1473], 'constructs': [1475], 'were': [1476, 1574, 1601, 1624, 1662, 1705, 1757, 1837, 1846, 1881, 1905, 1979, 2034, 2093, 2129, 2299, 2369, 2391, 2411, 2431, 2559, 2633, 2903, 2923, 3232, 3350, 3363, 3382, 3410, 3459, 3545, 4284], '(24Stein': [1479], 'S.C.': [1480, 4763], 'Woods': [1481], 'Jones': [1483], 'N.A.': [1484], '345:': [1492], '437-443Crossref': [1493], '(497)': [1496], 'Rabbit': [1499], 'polyclonal': [1500], 'anti-phospho-S466': [1501], 'anti-iPFK-2': [1538, 3295], 'antibodies': [1573], 'raised': [1575, 2745, 4191], 'against': [1576, 2746, 4192], 'peptides.': [1578], 'peptides': [1580], 'SAMS': [1583], '(25Davies': [1585], 'S.P.': [1586], '86:': [1595], '123-128Crossref': [1596], '(373)': [1598], 'synthesized': [1602], 'V.': [1604], 'Stroobant': [1605], '(Ludwig': [1606], 'Institute': [1607], 'Cancer': [1609], 'Research,': [1610], 'Brussels,': [1611], 'Belgium).': [1612], 'For': [1613, 1689], 'measurement': [1615, 3385, 3417], 'kinetic': [1617, 2675, 2779], 'properties,': [1618], 'incubated': [1625, 1695, 1847, 1882, 2035, 2392, 2802, 2815, 2849, 2877, 2924, 3351, 3364, 3412, 3463, 3655], '1': [1627, 1853, 2107, 2589, 2593, 2886, 3224, 3372, 3828], 'mmMgATP': [1628], 'at': [1631, 2109, 2623, 2896, 4156, 4363], '30': [1632, 2178, 2183, 2214, 2219, 2897, 2900], '°C': [1633, 2111, 2176, 2181, 2187, 2212, 2217, 2223], '(26Deprez': [1634, 1712], 'Vertommen': [1636, 1669, 1714, 2278, 4875], '272:': [1648, 1726], '17269-17275Abstract': [1649, 1727], '(341)': [1657, 1735], 'aliquots': [1661], 'taken': [1663, 1706, 3206], 'assay': [1666, 2600], '(27Crepin': [1667, 2276], 'K.M.': [1668, 2277], 'Dom': [1671, 2280], '268:': [1681, 2290], '15277-15284Abstract': [1682, 2291], 'determination': [1690], '0.1': [1697], 'mm': [1698, 2380, 2887], 'Mg·[γ-32P]ATP': [1699], '(1000': [1700], 'cpm/pmol)': [1701], 'Aliquots': [1704], 'analyzed': [1708], 'amount': [1739, 2254], 'enzymes': [1742], 'used': [1743, 2173, 3760, 4393, 4414], 'each': [1745], 'experiment': [1746], 'given': [1748], 'figure': [1751, 1894, 2042], 'legends.': [1752, 1895], 'Peripheral': [1753], 'blood': [1754, 1764], 'mononuclear': [1755], 'isolated': [1758, 1966], 'centrifugation': [1760, 2441], 'whole': [1763], 'through': [1765, 2341, 3620, 3681], 'density': [1767], 'gradient': [1768], 'Ficoll-Paque': [1770], '(Amersham': [1771], 'Biosciences)': [1772], 'Petri': [1776], 'dishes': [1777], '(10-cm': [1778], 'diameter,': [1779], '10': [1780, 2303, 2379, 3034, 4626], '×': [1781, 2443], '106monocytes/dish)': [1782], 'RPMI': [1784, 2375], '1640': [1785, 2376], 'medium': [1786, 1833, 1899, 1985, 2377, 2423], '10%': [1788, 1988], '(v/v)': [1789, 1989], 'fetal': [1790, 1990], 'calf': [1791, 1991], 'serum': [1792, 2552], 'After': [1827, 2438, 2899, 3375], '2': [1828], 'h': [1829, 2108, 3192, 3225, 3236], 'culture,': [1831], 'nonadherent': [1835], 'removed': [1838, 2412, 2904], 'aspiration,': [1840], 'remaining': [1843], 'adherent': [1844], 'without': [1848, 2803, 2816, 2850, 3365, 3658, 4144], '(resting)': [1849], '(activated)': [1852], 'μg/ml': [1854], '(Escherichia': [1856], 'coli': [1857], '0111:B4,': [1858], 'Sigma).': [1859], 'percentage': [1861], 'cultures': [1866], '>85%': [1868], 'determined': [1870], 'fluorescence-activated': [1872], 'sorter': [1874], 'analysis': [1875], 'CD14': [1877], 'periods': [1888, 3355], 'time': [1890, 4274], 'indicated': [1891, 2039, 2388, 3354, 3360], 'Following': [1896], 'incubation,': [1897], 'aspirated,': [1901], 'immediately': [1906], 'lysed': [1907, 2045, 3383], '0.8': [1909, 2047], 'ml': [1910, 1956, 2048, 2373], 'ice-cold': [1912, 2050, 2435], 'lysis': [1913, 2051], 'buffer': [1914, 2052], 'assays': [1952], '0.5': [1955, 3222], '50': [1958], 'mmNaOH': [1959], 'Fru-2,6-P2': [1961, 2312, 3307, 3390, 3503, 3714, 4264, 4549, 4572, 4589, 4617], 'determination.': [1962], 'Total': [1963], 'RNA': [1964, 1971, 2102], 'High': [1969], 'Pure': [1970], 'isolation': [1972], 'kit': [1973], '(Roche': [1974], 'Molecular': [1975], 'Biochemicals).': [1976], 'HEK-293': [1977, 3745, 3811, 3963, 4291], "Dulbecco's": [1982], 'modified': [1983, 1998], "Eagle's": [1984], 'supplemented': [1986], 'serum.': [1992], 'transfection': [1994, 3809, 3913], 'protocol': [1995], 'calcium': [1999], 'phosphate': [2000, 2616, 2821], 'procedure': [2001], 'legends': [2043], 'Unless': [2088], 'otherwise': [2089], 'stated,': [2090], 'normoxic': [2096, 2967, 4551, 4681], '(95%': [2098], 'O2,': [2099], '5%': [2100], 'CO2).': [2101], 'reverse': [2104, 3183], 'transcribed': [2105], '37': [2110], 'random': [2113], 'primers,': [2114], 'cDNA': [2116, 2198, 2256], 'fragments': [2117], 'correspond': [2119], '(IL)-1β': [2122], '(271': [2123], 'bp)': [2124, 2128, 2201], '(140': [2127], 'amplified': [2130, 2203], 'primers': [2133], 'cycling': [2171], 'program': [2172], '95': [2175], 's,': [2179, 2184, 2215, 2220], '55': [2180], '72': [2186, 2222], '45': [2189, 2225], 's': [2190, 2226], '22': [2192, 2228], 'cycles.': [2193], 'As': [2194, 3305, 4128], 'control,': [2196], 'β-actin': [2197], 'fragment': [2199], '(612': [2200], 'following': [2206], 'primers:': [2207], '5′-GGCATCGTGATGGACTCCG-3′': [2208], '5′-GCTGGAAGGTGGACAGCGA-3′': [2210], '(95': [2211], '58': [2216], 'cycles).': [2229], 'amplification': [2231, 2240], 'cycle': [2232, 2244], 'number': [2233, 2245], 'varied': [2235], 'initially': [2236], 'establish': [2238], 'unsaturating': [2239], 'displayed': [2243], 'allows': [2246], 'illustration': [2248], 'representative': [2250], 'differences': [2251], 'present.': [2257], 'activities': [2298], 'assayed': [2300], '20%': [2305], '(w/v)': [2306], 'polyethylene': [2307], 'glycol': [2308], '6000': [2309], 'precipitate,': [2310], 'respectively.': [2311], 'measured': [2314, 2965, 3181, 3645, 4631], '(28Van': [2318], 'Schaftingen': [2319], 'Lederer': [2321], 'B.': [2322], 'Hers': [2325, 2354, 2458, 2528, 3624], 'H.G.': [2326, 2355, 2459, 2529, 3625], '1982;': [2330], '129:': [2331], '191-195Crossref': [2332], '(541)': [2335], 'glycolytic': [2339, 2516, 3705, 4737], 'flux': [2340, 2517, 3619, 3680, 3706, 4738], 'PFK-1': [2342, 3621, 3682], 'estimated': [2344, 2544], 'rate': [2347, 2483, 2490, 2508, 2627, 3610], 'detritiation': [2349, 2489, 2522, 3612, 3641, 3665], '[3-3H]glucose': [2351, 3643], '(29Hue': [2352, 2526, 3622], 'Res.': [2358, 2532, 3628], 'Commun.': [2359, 2533, 3629], '1974;': [2360, 2534, 3630], '58:': [2361, 2535, 3631], '532-539Crossref': [2362, 2536, 3632], '(58)': [2365, 2539, 3635], '5': [2372, 2396, 2445, 3844], 'containing': [2378, 4203], 'times.': [2389], 'Cells': [2390], 'oligomycin': [2394, 2948, 3026, 3047, 3070, 3327, 3446, 3458, 3490, 3570, 3594, 3606, 3659, 3676, 3854, 4255], 'min': [2397, 2415, 2493, 3037, 3415, 3857], 'prior': [2398], 'addition': [2401, 2418], 'tracer': [2403, 2525], 'amounts': [2404], '(0.3': [2405], 'μCi/ml)': [2406], 'radioactive': [2408, 2452, 3403], 'glucose.': [2409], 'Samples': [2410], 'periodically': [2413], '(0–15': [2414], 'after': [2416, 2680, 3398, 4739], 'glucose)': [2420], 'measure': [2425], 'formation': [2427, 2587], 'of3H2O.': [2428], 'samples': [2430, 2902], 'deproteinized': [2432], '1m': [2434], 'perchloric': [2436], 'acid.': [2437], 'neutralization': [2439], '(10,000': [2442], 'g,': [2444], 'min,': [2446, 2901], '4': [2447], '°C),3H2O': [2448], 'separated': [2450], '(30Bontemps': [2454], '1978;': [2462], '174:': [2463], '603-611Crossref': [2464], '(144)': [2467], '3H2O': [2473], 'linear': [2475], 'over': [2476, 2491, 3012], '15-min': [2478, 3376], 'experimental': [2479], 'period,': [2480], 'calculated': [2485, 2560], 'average': [2488], '15': [2492, 3414, 3465, 3837, 3856], 'nanomoles': [2497], 'detritiated': [2500], 'per': [2501, 2503], 'minute': [2502], 'milligram': [2504], 'protein.': [2506], 'may': [2509], 'give': [2510], 'underestimation': [2512], 'net': [2515], 'because': [2518], 'incomplete': [2521], 'Proteins': [2542], 'method': [2547], 'Bradford': [2549], 'bovine': [2551], 'albumin': [2553], 'standard.': [2556], 'Kinetic': [2557], 'constants': [2558], 'computer': [2562], 'fitting': [2563], 'data': [2566], 'hyperbola': [2569], 'describing': [2570], 'Michaelis-Menten': [2572], 'equation': [2573], 'nonlinear': [2575], 'least': [2576], 'square': [2577], 'regression.': [2578], 'One': [2579], 'unit': [2580], 'corresponds': [2584], 'μmol': [2590], '(PFK-2)': [2591], 'nmol': [2594], 'product/min': [2597], 'Purified': [2602, 2872], 'stoichiometry': [2610, 4174], 'close': [2611, 4178], '0.7': [2613], 'mol': [2614], 'incorporated/mol': [2617], 'subunit,': [2620], 'one': [2624], 'site.': [2625], 'extent': [2630], 'AMP': [2636, 2882, 2944, 4467, 4483, 4564, 4643], '(Fig.1A),': [2637], 'correlated': [2640, 3709], '(Fig.': [2644, 3124, 3226, 3297, 3303, 3312, 3323, 3480, 3493, 3499, 3505, 3581, 3599, 3882, 3921, 4024, 4030], '1B).': [2645], 'treatment': [2647], 'led': [2650, 2739], '2.5-fold': [2653], 'Vmax': [2656], 'no': [2660, 3117, 3318, 3877, 4500, 4730], 'significant': [2661, 3433, 3440, 4731], 'change': [2662], 'Km': [2664], '6-phosphate': [2667], 'MgATP': [2669, 2832, 2888], '(Table': [2670, 2688], 'I).': [2671], 'changes': [2673, 3508], 'properties': [2676, 2780], 'resemble': [2677], 'those': [2678, 4678], 'seen': [2679, 3568], 'I)': [2689], 'similarity': [2726, 4151], 'among': [2727], 'sequences': [2729], 'us': [2740], 'use': [2742], 'antibody': [2744, 2765, 3296, 3890, 4190], '(anti-pS466)': [2753], 'study': [2755, 3763, 4324, 4690], 'iPFK2.': [2761], 'Immunoblotting': [2762], '(Fig.2).Table': [2773], 'IEffects': [2774], 'PFK-2iPFK-2heart': [2785], 'PFK-2w/o': [2786], 'AMPKw/': [2787, 2789], 'AMPKw/o': [2788], 'AMPKVmax(milliunits/mg': [2790], 'protein)10': [2791], '±': [2792, 2794, 2805, 2807, 2823, 2825, 2827, 2829, 2834, 2836, 2838, 2840, 3426, 3827, 3836], '125': [2793], '21-ap': [2795], '<': [2796, 2809, 2843, 3436, 3443], '0.01': [2797, 2810, 2844], 'comparison': [2799, 2812, 2846, 3692], 'sample': [2801, 2814, 2848], 'AMPK.50': [2804], '5125': [2806], '101-ap': [2808], 'AMPK.Km': [2817], '6-': [2820], '(μm)53': [2822], '250': [2824], '457': [2826], '346': [2828], '1Km': [2830], '(μm)650': [2833], '32582': [2835], '37930': [2837], '12745': [2839], '51-a': [2841], 'p': [2842], 'Open': [2852], 'table': [2853], 'new': [2856], 'tab': [2857], 'FIG.': [2858], '2Immunoblot': [2859], 'anti-pS466': [2870, 2911, 3889], 'antibody.': [2871], '(0.15': [2874], 'mg/ml)': [2875], '(0.6': [2880], 'unit/ml),': [2881], '(0.2': [2883], 'mm),': [2884, 2939], 'final': [2891], 'volume': [2892], '20': [2894, 3036], 'μl': [2895], '°C.': [2898], 'SDS-PAGE': [2906], 'immunoblotted': [2908], 'antibody.View': [2912], 'Large': [2913, 3450], 'Image': [2914, 3451], 'Figure': [2915, 3452], 'ViewerDownload': [2916, 3453], '(PPT)': [2917, 3454], 'To': [2918, 3601, 3719], 'activate': [2919, 4490], 'AMPK,': [2920, 2934], 'resting': [2921, 3339, 3485, 3552, 3673, 3689, 4068, 4497, 4607, 4645], 'activators': [2932], 'namely': [2935, 4160], '5-aminoimidazole-4-carboxamide': [2936], 'riboside': [2937, 3115], '(0.5': [2938], 'precursor': [2941], 'analog': [2945], 'ZMP': [2946, 3139], '(1': [2949], 'μm),': [2950], 'phosphorylation.': [2955], 'Basal': [2956], 'low': [2960], 'perfused': [2968, 3066], 'hearts': [2969, 3068, 3131], 'culture': [2973], 'remained': [3010, 4658], 'unchanged': [3011, 4659], 'period': [3015, 3469, 3540], '(Fig.3).': [3016], 'By': [3017, 3314, 4603], 'contrast,': [3018, 3315], 'progressively': [3021], 'during': [3023, 4297, 4332], 'reach': [3030], 'maximal': [3031, 3044, 4674], 'values': [3032, 3422, 4675], 'between': [3033], 'before': [3038], 'decreasing': [3039], 'toward': [3040], 'basal': [3041, 4465], 'levels.': [3042], 'effect': [3045, 3118, 3319, 3434, 3441, 3516, 3604, 3733, 3765, 3878, 4003, 4732], '∼2–3-fold': [3052], 'greater': [3053, 3073], 'than': [3054, 3590, 4629, 4653], 'observed': [3056, 3064, 3592, 3667, 4129, 4679], 'same': [3060, 4158, 4273], 'difference': [3061], 'already': [3063, 3238], 'rat': [3067, 3130], 'where': [3069], '5-Aminoimidazole-4-carboxamide': [3114], 'had': [3116, 3317, 3876, 4729], '3)': [3125], 'reported': [3128, 3239], 'does': [3140], 'not': [3141, 3687, 4591, 4611, 4701], 'transcription-PCR': [3184], 'up': [3189, 3652], '12': [3191, 3235], 'compared': [3196, 3523, 3671], 'early': [3202], 'IL-1β': [3205, 3216], 'monocytes.': [3215, 3342, 3674, 3690, 4064, 4316, 4662, 4706], 'mRNA': [3219, 3282], '4A).': [3227], 'Both': [3228], 'levels': [3229], 'maintained': [3233], 'corresponded': [3283], 'detected': [3290, 4187], 'immunoblotting': [3292, 3886], '4B)': [3298], '5A).': [3304], 'expected,': [3306], 'concentration': [3308, 3504, 4468, 4484, 4547, 4565, 4615, 4623, 4640], 'parallel': [3311], '5B).': [3313], '5C).FIG.': [3324], '5Effect': [3325], 'Fru-2': [3333], ',6-P2': [3334], 'LPS-activated': [3341, 3347, 3448, 3487, 3554, 3579, 3669, 3684, 4063, 4252, 4315, 4661], 'Resting': [3343, 3528], '(squares)': [3345], '(circles)': [3349], 'time.': [3357], 'At': [3358], 'time,': [3361], '(open': [3366], 'symbols)': [3367, 3371], '(filled': [3370], 'μm': [3373], '(A),': [3389], '(B),': [3392], '(C).': [3396], 'D,': [3397, 3699], '5-min': [3399], 'added,': [3406], 'detritiation.': [3420], 'means': [3425], 'S.E.': [3427], '3–5': [3429], 'different': [3430], 'preparations.': [3431], '*,': [3432], '(p': [3435, 3442], '0.01)': [3437], 'LPS;#,': [3439], '0.05)': [3444], 'cells.View': [3449], 'effects': [3456, 4712], 'min.': [3466], 'too': [3471], 'short': [3472], 'affect': [3474], '(mRNA': [3477], 'protein)': [3479], '4).': [3481], '5C).': [3494], '5A)': [3500], '5B),': [3506], 'only': [3509, 3577], 'occurring': [3510], 'expressing': [3513], 'iPFK-2.': [3514, 4163, 4295], 'investigated': [3521, 3743, 4001], '6': [3536], 'h,': [3537], 'sufficient': [3541], 'induce': [3543], 'iPFK-2,': [3544, 4076, 4462, 4669], 'submitted': [3546, 4556], 'monocytes,': [3555, 4608, 4666], 'episode': [3558], 'resulted': [3559, 3817], 'activation,': [3562], 'less': [3565, 3589], 'pronounced': [3566], '(Fig.6A).': [3571], 'Hypoxia': [3572], 'but': [3576, 3686, 3875, 4735], '6B).': [3582], 'hypoxia-induced': [3584], 'paralleled': [3596], '6).': [3600, 3851], 'evaluate': [3602], '[3-3H]glucose,': [3614], 'estimation': [3616], 'measured.': [3639], '12h,': [3654], '(Fig.5D).': [3660], 'Fig.': [3694], '5,': [3695], 'A,': [3696], 'B,': [3697], 'indicates': [3700], 'remarkably': [3708], 'activity.': [3718, 4581, 4825], 'test': [3720], 'mutant': [3737], '(α1DN': [3740], 'AMPK)': [3741], 'cells.': [3746, 4043, 4479, 4498, 4602, 4634, 4683], 'high': [3755, 4475], 'efficiency': [3756], '5–10-fold': [3820], 'total': [3823], '(7': [3826], 'microunits/mg': [3829, 3838], 'untransfected': [3832], '67': [3835], 'μg': [3845], 'DNA,': [3848], 'n': [3849], '=': [3850], 'Incubation': [3852], 'endogenous': [3860, 3880, 3920], '(4-fold)': [3862], '(2-fold)': [3866], 'time-dependent': [3869, 3893], 'manner': [3870], '(Fig.7,': [3871], 'B)': [3874], '7B).': [3883], 'addition,': [3885], 'revealed': [3891], '(Fig.7C).': [3897], 'demonstrated': [3900], 'character': [3903], 'α1DN': [3906, 4018], 'verifying': [3910], 'abolished': [3914, 4020], 'oligomycin-induced': [3916, 4037, 4278], '7A)': [3922], 'wild-type': [3960], 'co-expression': [4016], '7D)': [4025], '7B),': [4031], 'demonstrating': [4032], 'mediates': [4035], 'intact': [4042], 'presented': [4046], 'here': [4047], 'suggest': [4048], 'resembling': [4080], 'PFK-2,': [4082, 4132, 4198, 4262], 'target': [4090], 'theVmax': [4140], '(∼2-fold)': [4143], 'changing': [4145], 'theKm': [4146], 'substrates.': [4149], 'suggests': [4152], 'site,': [4159], 'finding': [4165], 'supported': [4168], 'fact': [4171, 4743], '(i)': [4173], '1,': [4180], '(ii)': [4181], 'could': [4185, 4848], 'using': [4188], '(iii)': [4200], 'concentration,': [4265], 'all': [4270], 'followed': [4271], 'course.': [4275], 'Finally,': [4276], 'completely': [4285], 'blocked': [4286], 'Therefore,': [4296, 4684], 'hypoxia,': [4298, 4558, 4835], 'subsequent': [4303], 'mediate': [4309], 'While': [4317], 'work': [4319], 'progress,': [4322], 'macrophages': [4331, 4696], 'anoxia': [4333], 'published': [4335], '(31Kawaguchi': [4336, 4371, 4508], 'Veech': [4338, 4373, 4510], 'R.L.': [4339, 4374, 4511], 'Uyeda': [4340, 4375, 4512], '276:': [4346, 4381, 4518], '28554-28561Abstract': [4347, 4382, 4519], '(64)': [4355, 4390, 4527], 'obtained': [4361], 'variance': [4364], 'our': [4366, 4416, 4725], 'results.': [4367], 'Kawaguchi': [4368], 'H36.12j': [4395, 4458, 4633, 4655, 4682, 4695], 'macrophage': [4396], 'immortal': [4397], 'line': [4399], 'model.': [4402], 'tumor-derived': [4404], 'respects': [4409], 'study.': [4417], 'Similar': [4418], 'many': [4420], 'other': [4421], 'tumor': [4422], 'overexpress': [4461], 'cyclic': [4466, 4482, 4491, 4539, 4563, 4642], '>30': [4470], 'pmol/g': [4471, 4648], 'abnormally': [4474], 'value': [4476], 'unstimulated': [4478], 'elevated': [4481, 4546], 'would': [4485], 'expected': [4487], 'fully': [4489], 'AMP-dependent': [4492, 4540], 'Although': [4499], 'direct': [4501], 'vitroevidence': [4503], 'presented,': [4505], 'authors': [4507], 'suggested': [4530], 'kinase,': [4542], 'thus': [4543, 4849], 'explaining': [4544], 'increased,': [4561], 'whereas': [4562], 'decreased,': [4566], 'fall': [4570], 'supposedly': [4574], 'mediated': [4575], 'decrease': [4578], 'From': [4582], 'study,': [4584], 'it': [4585], 'involved': [4592], 'contrast': [4604], 'expressed,': [4612], '∼2': [4619], 'pmol/mg': [4620], 'protein,': [4621], 'times': [4627], 'lower': [4628, 4652], 'Furthermore,': [4635], 'found': [4637], '(4': [4647], 'cells)': [4649], '10-fold': [4651], 'Fru-2,6-P2concentrations': [4672], 'conclusions': [4686], 'drawn': [4687], 'probably': [4700], 'applicable': [4702], 'normal': [4704], 'Few': [4707], 'studies': [4708], 'striking': [4711], 'absence': [4719], 'additional': [4721], 'stimuli.': [4722], 'Likewise,': [4723], 'experiments,': [4726], 'alone': [4728], 'activation.': [4741], 'monocyte': [4745, 4824], 'responses': [4746], 'enhanced': [4750], 'stimulants': [4752], 'interferon-γ': [4757], '(32West': [4758], 'M.A.,': [4759], 'Li,': [4760], 'Seatter': [4762], 'Bubrick': [4764], 'Trauma.': [4767], '1994;': [4768], '37:': [4769], '82-90Crossref': [4770], '(70)': [4773], '33Hempel': [4776], 'S.L.': [4777, 4799], 'Monick': [4778], 'M.M.': [4779], 'Hunninghake': [4780], 'G.W.': [4781], 'Respir.': [4784], 'Mol.': [4786], '14:': [4789], '170-176Crossref': [4790], '(90)': [4793], '34Metinko': [4796], 'A.P.': [4797], 'Kunkel': [4798], 'Standiford': [4800], 'T.J.': [4801], 'Strieter': [4802], 'R.M.': [4803], 'Clin.': [4805], 'Invest.': [4806], '1992;': [4807], '90:': [4808], '791-798Crossref': [4809], '(154)': [4812], 'reflects': [4815], 'important': [4817], 'role': [4818], 'coordinating': [4823], 'postulate': [4827], 'primes': [4830], 'respond': [4833], 'inevitably': [4837], 'around': [4841], 'tissues.': [4843], 'subsequently': [4845], 'furnishing': [4858], 'boost': [4861], 'thank': [4866, 4885], 'who': [4869], 'kindly': [4870], 'provided': [4871], 'construct,': [4873], 'help,': [4877], 'interest.': [4882], 'H.': [4887], 'help': [4890], 'preparing': [4892], 'paper.': [4894]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024883161', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 26}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-12-12T17:10:51.541881', 'created_date': '2016-06-24'}