Publication Information

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2263, 2281, 2317, 2554, 2577, 2645, 2693, 2751, 2830, 2835, 2916, 2970, 3167, 3218, 3234, 3279, 3391, 3404, 3679, 3792, 3845, 3871, 3886, 3995, 4005, 4024, 4117, 4253, 4257, 4270, 4287, 4378, 4404, 4420, 4427, 4517, 4580, 4677, 4701, 4715, 4735, 4855, 4976, 5042, 5073, 5089, 5146, 5152, 5167, 5202, 5209], 'lamin': [34, 41, 59, 63, 82, 117, 142, 159, 209, 216, 234, 238, 257, 292, 317, 334, 520, 641, 689, 766, 973, 1054, 1320, 1415, 1497, 1571, 1664, 2556, 2673, 3176, 3204, 3221, 3238, 3252, 3367, 3419, 3438, 3485, 3505, 3512, 3524, 3541, 3551, 3625, 3656, 3680, 3695, 3757, 3771, 3826, 3836, 3852, 3876, 3921, 4006, 4014, 4031, 4039, 4076, 4112, 4118, 4152, 4210, 4239, 4265, 4274, 4288, 4314, 4386, 4406, 4430, 4447, 4457, 4492, 4506, 4702, 4725, 4745, 4810, 4929, 4966, 5010, 5019, 5043, 5058, 5066, 5153], 'B': [35, 42, 60, 64, 83, 95, 118, 143, 160, 210, 217, 235, 239, 258, 270, 293, 318, 335, 642, 690, 880, 976, 1405, 1572, 1665, 1797, 2557, 2674, 3135, 3205, 3222, 3239, 3253, 3368, 3380, 3410, 3420, 3439, 3486, 3506, 3513, 3525, 3542, 3626, 3657, 3665, 3681, 3696, 3758, 3772, 3827, 3837, 3853, 3877, 3922, 4007, 4015, 4032, 4040, 4153, 4240, 4266, 4275, 4289, 4315, 4448, 4458, 4493, 4705, 4811, 4967, 5011, 5020, 5044, 5067], 'during': [36, 211, 482, 517, 711, 1576, 3207, 3226, 3257, 3553, 3760, 3988, 4009, 4158, 4450, 4495, 5013, 5045, 5212], 'apoptosis.': [37, 174, 212, 349, 1463, 4010, 4518, 4736, 5213], 'We': [38, 213, 2004, 3265, 3441, 3508, 3568, 3643, 3726, 4011], 'found': [39, 75, 214, 250, 3569, 3645, 4012], 'that': [40, 58, 76, 158, 215, 233, 251, 333, 1398, 1414, 3122, 3159, 3251, 3271, 3432, 3444, 3494, 3523, 3535, 3570, 3646, 3671, 3770, 3868, 3898, 3916, 3934, 4013, 4030, 4147, 4699, 4724, 4988, 5022, 5040, 5065, 5191], 'was': [43, 97, 119, 129, 144, 218, 272, 294, 304, 319, 814, 1759, 1768, 1776, 1803, 1820, 1852, 2183, 2255, 2258, 2312, 2582, 2597, 2655, 2733, 2860, 2896, 2958, 2965, 2974, 3137, 3242, 3382, 3421, 3489, 3498, 3527, 3674, 3774, 3819, 3847, 3879, 3889, 3918, 4236, 4242], 'phosphorylated': [44, 145, 162, 219, 320, 337, 2882, 3244, 3418, 4017], 'within': [45, 220, 4018], '1': [46, 221, 2088, 2447, 2463, 2511, 2517, 2720, 2723, 2749, 2792, 2794, 3119, 3151, 4019], 'h': [47, 222, 2448, 2758, 3163, 4020], 'after': [48, 146, 223, 321, 2454, 2602, 2624, 2735, 3164, 3231, 3389, 3869, 3992, 4021], 'addition': [49, 132, 224, 307, 4023, 4269, 5026], 'DNA': [52, 67, 168, 227, 242, 343, 819, 1411, 1422, 1544, 2178, 2310, 2318, 2325, 3126, 3144, 3285, 3350, 3445, 3480, 3502, 3653, 4045, 4710, 5158], 'topoisomerase': [53, 228, 771, 794, 3027], 'I': [54, 229, 795, 3028], 'inhibitor,': [55, 113, 230, 288, 4167], 'camptothecin,': [56, 231, 3030], 'preceded': [62, 237], 'fragmentation.': [68, 243], 'Using': [69, 244], 'a': [70, 245, 370, 436, 441, 473, 498, 770, 793, 987, 1048, 1145, 1233, 1587, 2070, 2148, 2940, 3268, 3373, 3572, 3779, 4108, 4245, 4379, 4509, 4674], 'cell-free': [71, 246, 925, 1590, 3269, 3387, 3661], 'system': [72, 247, 1591, 3270, 3388, 3662], 'we': [73, 248, 1569, 3202, 3272, 3967, 5023], 'also': [74, 138, 249, 313, 815, 886, 3243, 3365, 3488, 3644, 3690, 3971, 4390, 4646, 5006], 'cytosol': [77, 127, 252, 302, 2641, 2930, 3344, 3433, 3450, 3630, 3925, 3939], 'from': [78, 90, 125, 253, 265, 300, 1727, 1761, 1770, 1778, 1790, 1800, 1805, 1818, 1822, 1837, 1841, 1854, 2320, 2411, 2422, 2430, 2630, 2931, 3345, 3354, 3362, 3369, 3396, 3434, 3631, 3873, 3926, 3940, 5194], 'camptothecin-treated': [79, 254], 'induced': [81, 256, 890, 3349, 3447, 3482, 3628, 3829, 4651], 'isolated': [88, 263], 'nuclei': [89, 264, 2145, 2173, 2629, 2978, 3353, 3371, 3392], 'untreated': [91, 266, 2047, 2631, 3355], 'cells.': [93, 154, 268, 329, 1978, 3211, 3929, 3978, 4720, 5034], 'Lamin': [94, 269, 709, 811, 877, 3134, 3379, 4643], 'prevented': [98, 273], 'by': [99, 110, 121, 131, 163, 274, 285, 296, 306, 338, 450, 502, 505, 762, 891, 1062, 1244, 1325, 2134, 2185, 2276, 2307, 2466, 2475, 2568, 2726, 2888, 2912, 2950, 3423, 3448, 3454, 3483, 3518, 3530, 3629, 3682, 3776, 3798, 3830, 3881, 3924, 4244, 4335, 4409, 4652], 'protein': [101, 276, 524, 527, 536, 539, 559, 2561, 2746, 2899, 3031, 3136, 3903, 4316], 'kinase': [102, 277, 507, 528, 540, 560, 1813, 2779, 2865, 3032, 3547, 3673, 3687, 4103, 4216, 4317], 'C': [103, 278, 561, 3688, 3866, 4318], '(PKC)': [104, 279, 562], 'inhibitor': [105, 280, 773, 796, 3029, 3458, 3575, 3731, 4217], '7-hydroxystaurosporine': [106, 281, 1721], '(UCN-01)': [107, 282], 'not': [109, 284, 1067, 1668, 3528, 3539, 3623, 3649, 3675], 'Cdc2': [112, 287, 4102], 'flavopiridol.': [114, 289], 'Phosphorylation': [115, 290, 504], 'inhibited': [120, 295, 3453, 3517, 3775, 4243, 4264], 'immunodepletion': [122, 297, 3870, 3888, 4256], 'PKCα': [124, 136, 164, 299, 311, 339, 1836, 2963, 3834, 3872, 3902, 3917, 3935, 3973, 3984, 4281], 'activated': [126, 301, 3937], 'restored': [130, 305, 3835, 4273], 'purified': [134, 309], 'PKCα.': [135, 310, 2971, 3863], 'activity': [137, 312, 3797, 3985, 4282, 5201], 'increased': [139, 314, 3224, 3986, 4283], 'rapidly': [140, 315, 3225, 3987], 'as': [141, 316, 375, 472, 1681, 2144, 2165, 2188, 2314, 2669, 2967, 3025, 3142, 4038, 5171], 'initiation': [147, 322], 'apoptotic': [150, 325, 822, 2990, 3125, 3284, 3346, 3363, 3397, 3435, 3449, 3632, 3684, 3831, 3856, 3874, 3927, 3941, 4026, 4258, 4526, 5032, 5147], 'response': [151, 326, 1579], 'These': [155, 330, 3248, 3668, 4357, 4721], 'data': [156, 331, 4145], 'suggest': [157, 332, 4146, 4723], 'is': [161, 336, 497, 508, 760, 769, 885, 1241, 1466, 1512, 1667, 3172, 3260, 3548, 3762, 3936, 4001, 4016, 4041, 4104, 4149, 4370, 4389, 4497, 4508, 4838, 4931, 4986, 5055, 5063, 5084, 5189], 'proteolyzed': [166, 341], 'before': [167, 342, 1934, 2533, 2660], 'fragmentation': [169, 344, 820, 1423, 2179, 2311, 2326, 3127, 3286, 3351, 3446, 3481, 3503, 3654, 4046, 4711, 5159], 'undergoing': [173, 348], 'The': [350, 465, 495, 656, 970, 1136, 1660, 1845, 2287, 2387, 2535, 2594, 2628, 2731, 2763, 2806, 2908, 2945, 2956, 3491, 3884, 3998, 4143, 4313, 4861], 'nuclear': [351, 364, 377, 479, 515, 622, 638, 1425, 1674, 3180, 4394, 4425, 4461, 4501, 4707, 4933, 5075, 5079, 5169, 5196], 'lamins': [352, 677, 1402, 1445], 'are': [353, 660, 807, 1446, 2985, 4073, 4359], 'karyophilic': [354], 'proteins': [355, 2418], 'located': [356, 616, 4839], 'at': [357, 991, 1742, 1891, 2069, 2112, 2125, 2147, 2157, 2345, 2396, 2443, 2540, 2571, 2737, 2753, 2846, 2902, 2942, 2952, 3635, 4284, 4747, 4752, 4968], 'nucleoplasmic': [359], 'surface': [360], 'inner': [363], 'membrane': [365], 'where': [366], 'they': [367], 'assemble': [368], 'polymeric': [371], 'structure': [372, 500, 3183, 5174], 'referred': [373], 'lamina': [378, 466, 496, 516, 4462, 5076, 5170, 5197], '(for': [379], 'review,': [380], 'see': [381], 'Refs.': [382], '1Gerace': [383], 'L.': [384, 564, 1030, 1428, 1520, 1643, 3583, 3703, 4226, 4467, 4682, 4791, 4820, 4911, 5094], 'Burke': [385, 565], 'B.': [386, 566, 767, 1685, 3577, 4220], 'Annu.': [387, 567], 'Rev.': [388, 568], 'Cell': [389, 402, 416, 569, 582, 596, 646, 912, 1036, 1158, 1188, 1434, 1502, 1617, 1919, 2021, 2202, 3014, 3045, 3062, 3085, 3108, 3192, 3298, 3328, 3558, 4061, 4088, 4123, 4136, 4435, 4567, 4633, 4688, 4797, 4826, 4917, 4952, 5100], 'Biol.': [390, 403, 417, 570, 583, 597, 647, 698, 862, 913, 1037, 1121, 1159, 1173, 1189, 1379, 1435, 1503, 1705, 3193, 3559, 3711, 3808, 3951, 4089, 4124, 4137, 4298, 4344, 4436, 4475, 4634, 4689, 4798, 4827, 4918, 5101], '1988;': [391, 571, 700], '4:': [392, 572], '335-374Crossref': [393, 573], 'PubMed': [394, 407, 421, 574, 587, 601, 651, 706, 754, 872, 917, 936, 965, 1024, 1041, 1101, 1131, 1163, 1182, 1196, 1224, 1284, 1314, 1359, 1389, 1439, 1482, 1507, 1535, 1601, 1622, 1639, 1655, 1697, 1715, 2026, 2043, 2207, 3019, 3050, 3067, 3090, 3113, 3197, 3303, 3320, 3333, 3469, 3563, 3617, 3721, 3749, 3816, 3961, 4066, 4093, 4128, 4185, 4308, 4352, 4440, 4485, 4557, 4572, 4638, 4668, 4693, 4785, 4802, 4831, 4905, 4922, 5000, 5105, 5138], 'Scopus': [395, 408, 422, 575, 588, 602, 652, 755, 873, 918, 937, 966, 1025, 1042, 1102, 1132, 1164, 1197, 1225, 1285, 1315, 1360, 1390, 1440, 1483, 1508, 1536, 1602, 1623, 1656, 1698, 1716, 2027, 2208, 2226, 3020, 3051, 3068, 3091, 3114, 3198, 3304, 3334, 3470, 3564, 3618, 3722, 3750, 3962, 4067, 4094, 4129, 4186, 4309, 4441, 4486, 4558, 4573, 4639, 4669, 4694, 4786, 4803, 4832, 4906, 4923, 5001, 5106, 5139], '(520)': [396, 576], 'Google': [397, 410, 424, 577, 590, 604, 654, 707, 740, 757, 789, 839, 875, 920, 939, 968, 1027, 1044, 1104, 1134, 1166, 1183, 1199, 1227, 1287, 1317, 1362, 1392, 1442, 1485, 1510, 1538, 1563, 1604, 1625, 1640, 1658, 1700, 1718, 2029, 2044, 2210, 2228, 3003, 3022, 3053, 3070, 3093, 3116, 3200, 3306, 3321, 3336, 3472, 3566, 3591, 3620, 3724, 3752, 3817, 3964, 4069, 4096, 4131, 4141, 4188, 4205, 4234, 4311, 4353, 4443, 4488, 4546, 4560, 4575, 4594, 4613, 4641, 4671, 4696, 4788, 4805, 4834, 4908, 4925, 4958, 5003, 5108, 5141], 'Scholar,': [398, 411, 578, 591, 940, 1028, 1105, 1167, 1184, 1200, 1288, 1363, 1605, 1626, 1641, 1701, 2030, 2211, 3004, 3054, 3307, 3322, 3592, 4132, 4189, 4547, 4561, 4789, 4909], '2Nigg': [399, 579], 'E.A.': [400, 580, 644, 1500, 3190, 3556, 3581, 4086, 4121, 4134, 4197, 4224, 4433], 'Semin.': [401, 581, 645, 799, 1501, 3191, 3557, 4087, 4122, 4135, 4434], '1992;': [404, 584, 648, 1504, 3194, 3560, 4090, 4125, 4437, 4591, 4955], '3:': [405, 419, 585, 599, 649, 1505, 3195, 3561, 4091, 4126, 4438, 4956], '245-253Crossref': [406, 586, 650, 1506, 3196, 3562, 4092, 4127, 4439], '(64)': [409, 423, 589, 603, 653, 1509, 1717, 3199, 3565, 4095, 4130, 4442], '3McKeon': [412, 592], 'F.D.': [413, 593], 'Curr.': [414, 594, 1156, 1172], 'Opin.': [415, 595, 1157], '1991;': [418, 598, 4138], '82-86Crossref': [420, 600], 'Scholar).': [425, 605, 655, 708, 804, 876, 969, 1135, 1228, 1393, 1443, 1486, 1564, 1659, 1719, 2045, 2229, 3094, 3337, 3473, 3567, 3725, 3965, 4070, 4097, 4142, 4312, 4444, 4489, 4642, 4672, 4835, 4926], 'Lamins': [426], 'belong': [427], 'family': [430, 1143], 'intermediate': [432], 'filaments,': [433], 'which': [434, 3786, 4369, 4960, 5054, 5180], 'share': [435], 'tripartite': [437], 'organization': [438], 'consisting': [439], 'central': [442, 666, 1146, 4365], 'α-helical': [443, 667, 4366, 4843, 5051], 'rod': [444, 668, 4367, 4844, 5052], 'domain': [445, 4845], 'conserved': [447, 988, 4364, 4749, 4842, 5050], 'size,': [448], 'flanked': [449], 'N-': [451], 'C-terminal': [453, 627], 'non-α-helical': [454, 628], 'end': [455, 2576], 'domains': [456], 'variable': [458], 'size': [459], 'sequence': [461, 1050, 4397, 4422], '(see': [462], 'Fig.': [463, 3118, 3215, 3429, 3474, 3520, 3766, 3864, 3913, 3982], '9).': [464, 4356, 4400, 4983], 'has': [467, 713, 982, 1056, 3689, 4414, 4452, 4520, 4645, 4740, 4814, 4865], 'been': [468, 611, 714, 984, 1057, 1679, 3691, 4322, 4415, 4453, 4521, 4647, 4741, 4815, 4866], 'suggested': [469, 1680, 3493, 3670, 3915], 'serve': [471], 'major': [474], 'chromatin': [475, 493, 3182, 4503, 5148, 5177, 5184, 5192, 5210], 'anchoring': [476], 'site': [477, 971, 3791, 4252, 4813, 4837], 'scaffold-associated': [480, 1675, 5178], 'regions': [481], 'interphase': [483, 3188, 3698, 4451], 'possibly': [485], 'be': [487, 1060, 1323, 1455, 3452, 3516, 3860, 4373, 4962, 5007, 5161], 'involved': [488, 1457, 4074, 5008], 'organizing': [490], 'higher': [491], 'order': [492], 'domains.': [494], 'dynamic': [499], 'regulated': [501], 'phosphorylation.': [503, 2675, 3440, 3543, 4276], 'p34cdc2': [506, 657, 1492, 3672, 4079], 'key': [509], 'dissolution': [512, 5072], 'mitosis.': [518], 'Other': [519], 'kinases': [521, 1498, 4072], 'include': [522], 'mitogen-associated': [523, 4081], 'kinases,': [525], 'c-AMP-dependent': [526, 535], '(PKA)': [529], '1The': [530], 'abbreviations': [531], 'are:': [533], 'PKA,': [534], 'kinase;': [537], 'PKC,': [538, 4083], 'C;': [541], 'CPT,': [542, 1720, 3484], 'camptothecin;': [543], 'UCN-01,': [544], '7-hydroxystaurosporine;': [545], 'DCI,': [546], '3,4-dichloroisocoumarin;': [547], 'PBS,': [548], 'phosphate-buffered': [549], 'saline;': [550], 'AEBSF,': [551, 2093, 2521, 2796], '4-(2-aminoethyl)benzenesulfonyl': [552], 'fluoride;': [553], 'PAGE,': [554], 'polyacrylamide': [555], 'gel': [556, 2410], 'electrophoresis.': [557], '(1Gerace': [563], 'Major': [606], 'PKC': [607, 2761, 3730, 3793, 3796, 4148, 4166, 4272, 4333, 4410], 'sites': [609, 659, 4320, 4358], 'have': [610, 1678, 4321], 'mapped': [612, 985, 4323, 4816], 'serine': [614, 1676, 3280, 3456, 3495, 4989], 'residues': [615, 634], 'close': [618], 'proximity': [619], 'localization': [623], 'region,': [629], 'these': [633, 3900], 'interferes': [635], 'with': [636, 721, 730, 846, 1514, 1873, 1911, 1924, 1943, 1973, 1994, 2246, 2260, 2278, 2469, 2530, 2551, 2640, 2652, 2745, 2767, 2811, 2898, 2924, 2929, 3096, 3131, 3139, 3262, 3339, 3394, 3408, 4261, 4536, 5086], 'transport': [639], '(2Nigg': [643, 1499, 3189, 3555, 4085, 4120, 4432], 'on': [661, 2729, 2877, 3415, 3651], 'both': [662, 3184, 3501], 'sides': [663], 'domain.': [669], 'While': [670], 'many': [671], 'mammalian': [672], 'contains': [674], 'three': [675, 2060, 2349, 2774], 'distinct': [676], '(lamins': [678], 'A,': [679], 'B,': [680], 'C),': [682], 'express': [687], 'primarily': [688], '(4Fields': [691], 'A.P.': [692, 3705, 4342, 4469], 'Pettit': [693], 'G.R.': [694], 'May': [695], 'W.S.': [696], 'J.': [697, 831, 834, 861, 911, 1035, 1120, 1214, 1378, 1433, 1524, 1651, 1704, 3010, 3104, 3710, 3743, 3807, 3950, 4057, 4179, 4297, 4343, 4474, 4586, 4589, 4605, 4608, 4632, 4664, 4687, 4796, 4825, 4916, 5099], 'Chem.': [699, 863, 1122, 1380, 1706, 3712, 3809, 3952, 4299, 4345, 4476], '263:': [701, 1533], '8253-8260Abstract': [702], 'Full': [703, 867, 869, 1126, 1128, 1177, 1179, 1193, 1219, 1221, 1311, 1384, 1386, 1710, 1712, 3716, 3718, 3813, 3956, 3958, 4303, 4305, 4349, 4480, 4482], 'Text': [704, 868, 870, 1127, 1129, 1178, 1180, 1194, 1220, 1222, 1312, 1385, 1387, 1711, 1713, 3717, 3719, 3814, 3957, 3959, 4304, 4306, 4350, 4481, 4483], 'PDF': [705, 871, 1130, 1181, 1195, 1223, 1313, 1388, 1714, 3720, 3815, 3960, 4307, 4351, 4484], 'proteolysis': [710, 881], 'reported': [715, 816, 4648], 'various': [717, 2989], 'cell': [718, 2499, 2536, 4157, 4259, 4527, 4578], 'lines': [719], 'treated': [720, 729, 845, 2049, 4535], 'different': [722], 'stimuli.': [723], 'etoposide': [731], '(VP-16)': [732], '(5Kaufmann': [733, 2996, 4539], 'S.H.': [734, 856, 952, 1011, 1088, 1346, 2997, 3606, 4540, 4772, 4892, 5125], 'Cancer': [735, 778, 1558, 2998, 3586, 4229, 4541], 'Res.': [736, 1559, 1618, 1692, 2022, 2203, 2222, 2999, 3015, 3046, 3063, 3086, 3109, 3299, 3329, 3587, 4062, 4230, 4542, 4568], '1989;': [737, 3000, 4543], '49:': [738, 3001, 4544], '5870-5878PubMed': [739, 3002, 4545], 'Scholar)': [741, 790, 840, 921, 1045, 1539, 3023, 3621, 3753, 4206, 4235, 4354, 4697, 5004, 5109], 'or': [742, 1404, 1792, 2348, 3398, 3655, 4704], 'camptothecin': [743, 1581, 1940, 3123, 3227, 3970, 3996], '(CPT)': [744], '(6Shimizu': [745, 927, 1592, 3460, 4991], 'T.': [746, 928, 1001, 1078, 1336, 1551, 1593, 3058, 3081, 3324, 3461, 4549, 4563, 4762, 4882, 4992], 'Pommier': [747, 929, 1556, 1594, 1614, 1633, 2018, 2037, 2199, 2218, 3011, 3042, 3059, 3082, 3105, 3295, 3314, 3325, 3462, 3948, 4058, 4295, 4550, 4564, 4993], 'Y.': [748, 775, 798, 930, 1261, 1267, 1557, 1595, 1615, 1634, 2019, 2038, 2200, 2219, 3012, 3043, 3060, 3083, 3106, 3296, 3315, 3326, 3463, 3949, 4059, 4296, 4551, 4565, 4994], 'Leukemia': [749, 931, 1596, 3464, 4552, 4995], '(Baltimore).': [750, 932, 1597, 3465, 4553, 4996], '1997;': [751, 933, 1598, 1694, 3064, 3466, 3713, 3953, 4300, 4477, 4554, 4665, 4997], '11:': [752, 934, 1599, 3467, 4555, 4998], '1238-1244Crossref': [753, 935, 1600, 3468, 4556, 4999], '(103)': [756, 938, 1603, 3471, 4559, 5002], 'Scholar),': [758, 1318, 1511, 3071, 3117, 3201, 3818, 4576, 4595, 4614, 4806, 4959, 5142], 'accompanied': [761], 'diminished': [763], 'levels': [764, 3904], 'Etoposide': [768], 'II': [772], '(7Pommier': [774], 'Teicher': [776], 'B.A.': [777, 4338], 'Therapeutics:': [779], 'Experimental': [780], 'Clinical': [782], 'Agents.': [783], 'Humana': [784], 'Press,': [785], 'Totowa,': [786], 'NJ1997:': [787], '153-174Crossref': [788], 'CPT': [792], '(8Pommier': [797], 'Oncol.': [800], '1996;': [801, 864, 1021, 1038, 1098, 1123, 1174, 1190, 1216, 1356, 1381, 1436, 1652, 1707, 3087, 3330, 3588, 3614, 4231, 4569, 4690, 4782, 4799, 4828, 4902, 4919, 5102], '23:': [802], '1-10Google': [803], 'Both': [805, 1670], 'drugs': [806], 'effective': [808], 'anti-cancer': [809], 'agents.': [810], 'B1': [812], 'precede': [818], 'thymocytes': [823], '(9Neamati': [824, 4598], 'N.': [825, 854, 1210, 4599], 'Fernandez': [826, 4600], 'A.': [827, 944, 961, 995, 1020, 1072, 1097, 1251, 1330, 1355, 1647, 1687, 3613, 4601, 4756, 4781, 4876, 4901, 5117, 5134], 'Wright': [828, 4602], 'S.': [829, 960, 1019, 1096, 1296, 1354, 1689, 3612, 4603, 4780, 4900, 5133], 'Kiefer': [830, 4604], 'McConkey': [832, 4606], 'D.J.': [833, 1204, 1703, 4340, 4607], 'Immunol.': [835, 4590, 4609], '1995;': [836, 962, 1160, 1281, 1308, 1479, 1560, 2223, 4610, 5135], '154:': [837, 4611], '3788-3795PubMed': [838, 4612], 'HeLa': [843], 'anti-CD95': [847], 'antibody': [848, 1799, 1832, 1851, 2452, 2558, 2895, 3823, 4247, 4263], '(10Mandal': [849], 'M.': [850, 910, 1186, 1259, 1265, 1290, 3740, 4176, 4631], 'Maggirwar': [851], 'S.B.': [852], 'Sharma': [853], 'Kaufmann': [855, 951, 1010, 1087, 1345, 4771, 4891, 5124], 'Sun': [857], 'S.-C.': [858], 'Kumar': [859], 'R.': [860, 908, 1607, 1630, 2011, 2034, 2192, 2213, 3006, 3035, 3100, 3288, 3311, 4053, 4629], '271:': [865, 1124, 1382, 1708], '30354-30359Abstract': [866], '(108)': [874], 'A': [878, 974, 1055, 1321, 1403, 2505, 2586, 2589, 2650, 3077, 3120, 3768, 3842, 3930, 4703, 4746], 'into': [882], '45-kDa': [883, 980, 3374, 4863, 5029], 'fragments': [884], 'observed': [887, 3442, 4522, 4862, 5024, 5037], 'serum': [892, 1877, 1996, 2495, 2528, 2592, 4616], 'starvation': [893, 4617], 'ras': [895], 'transformed': [896, 4619], 'primary': [897, 2451], 'rat': [898], 'embryo': [899, 4620], '(11Oberhammer': [901, 4622], 'F.A.': [902, 4623], 'Hochegger': [903, 4624], 'K.': [904, 1109, 1294, 1367, 3738, 4174, 4625], 'Froschl': [905, 4626], 'G.': [906, 1003, 1080, 1208, 1338, 4627, 4764, 4884, 4951], 'Tiefenbacher': [907, 4628], 'Pavelka': [909, 4630], '1994;': [914, 1532, 1619, 2023, 2204, 3047, 3300, 4202, 4635], '126:': [915, 4636], '827-837Crossref': [916, 4637], '(302)': [919, 4640], 'reconstituted': [924], 'systems': [926, 4528], '12Lazebnik': [941], 'Y.A.': [942, 999, 1076, 1334, 4760, 4880, 5115], 'Takahashi': [943, 5116], 'Moir': [945, 1004, 1081, 1339, 4765, 4885, 5118], 'R.D.': [946, 948, 1005, 1007, 1082, 1084, 1340, 1342, 4766, 4768, 4886, 4888, 5119, 5121], 'Goldman': [947, 1006, 1083, 1341, 4767, 4887, 5120], 'Poirier': [949, 1008, 1085, 1112, 1301, 1343, 1370, 4769, 4889, 5122], 'G.G.': [950, 1009, 1086, 1113, 1302, 1344, 1371, 4770, 4890, 5123], 'Earnshaw': [953, 1012, 1089, 1347, 4773, 4893, 5126], 'W.C.': [954, 1013, 1090, 1155, 1348, 4774, 4894, 5127], 'Proc.': [955, 1014, 1091, 1349, 3607, 4775, 4895, 5128], 'Natl.': [956, 1015, 1092, 1350, 3608, 4776, 4896, 5129], 'Acad.': [957, 1016, 1093, 1351, 3609, 4777, 4897, 5130], 'Sci.': [958, 1017, 1094, 1352, 3610, 4778, 4898, 5131], 'U.': [959, 1018, 1095, 1353, 3600, 3611, 4779, 4899, 5132], '92:': [963, 5136], '9042-9046Crossref': [964, 5137], '(483)': [967, 5140], 'cleavage': [977, 1409, 1416, 3148, 3240, 3487, 3658, 4726, 4812, 4850, 5012, 5041, 5068, 5206], 'yielding': [978, 3146], 'fragment': [981, 4864, 4874, 5021], 'recently': [983], 'aspartate': [989], 'residue': [990, 4751], 'position': [992, 4753], '230': [993, 4754], '(13Takahashi': [994, 1071, 1329, 4755, 4875], 'Alnemri': [996, 1073, 1331, 4757, 4877], 'E.S.': [997, 1074, 1202, 1332, 4758, 4878], 'Lazebnik': [998, 1075, 1266, 1333, 4759, 4879, 5111], 'Fernandes-Alnemri': [1000, 1077, 1335, 4761, 4881], 'Litwack': [1002, 1079, 1337, 4763, 4883], '93:': [1022, 1099, 1357, 3615, 4783, 4903], '8395-8400Crossref': [1023, 1100, 1358, 4784, 4904], '(472)': [1026, 1103, 1361, 4787, 4907], '14Rao': [1029, 4790, 4910], 'Perez': [1031, 1429, 4683, 4792, 4821, 4912, 5095], 'D.': [1032, 1430, 3803, 4684, 4793, 4822, 4913, 5096], 'White': [1033, 1431, 4685, 4794, 4823, 4914, 5097], 'E.': [1034, 1432, 1609, 1628, 1649, 2013, 2032, 2194, 2217, 3008, 3037, 3102, 3290, 3309, 3604, 3736, 4055, 4172, 4686, 4795, 4824, 4915, 5098], '135:': [1039, 1437, 4691, 4800, 4829, 4920, 5103], '1441-1455Crossref': [1040, 1438, 4692, 4801, 4830, 4921, 5104], '(513)': [1043, 1441, 4695, 4804, 4833, 4924, 5107], 'corresponding': [1046, 3153, 4809], 'consensus': [1049], 'for': [1051, 1913, 1997, 2053, 2115, 2129, 2174, 2384, 2399, 2446, 2462, 2543, 2599, 2670, 2740, 2756, 2849, 2871, 2905, 2962, 3174, 3500, 3550, 3677, 3920, 4035, 4151, 4160, 4375, 5057, 5175], 'caspases.': [1052], 'Furthermore,': [1053], 'shown': [1058, 3213, 3692, 3911, 3980, 4416, 4454, 4742, 4867], 'cleaved': [1061, 1243, 1324, 3138, 3366], 'caspase': [1063, 1068, 1142, 1230, 1245, 1326, 1408, 1451], '6': [1064, 1327, 2370, 3641, 4738], '(Mch-2α)': [1065], '3': [1069, 1246, 2054, 2247, 2604, 2855, 2906, 3162, 3359, 3377], '(CPP32/YAMA)': [1070], '15Duan': [1106, 1364], 'H.': [1107, 1365, 3742, 4178], 'Orth': [1108, 1366], 'Chinnaiyan': [1110, 1368], 'A.M.': [1111, 1169, 1369], 'Froelich': [1114, 1372], 'C.J.': [1115, 1373], 'He': [1116, 1374], 'W.-W.': [1117, 1375], 'Dixit': [1118, 1170, 1305, 1376], 'V.M.': [1119, 1171, 1306, 1377], '16720-16724Abstract': [1125, 1383], '(297)': [1133, 1391], 'death-related': [1137], 'cysteine': [1138], 'proteases': [1139, 1683, 3281, 4990], 'play': [1144, 4107], 'execution': [1150, 1460, 4733], 'phase': [1151, 1461, 4734], '(16Earnshaw': [1154], '7:': [1161], '337-343Crossref': [1162], '(510)': [1165], '17Chinnaiyan': [1168], '6:': [1175, 1191], '555-562Abstract': [1176], '18Whyte': [1185], 'Trends': [1187], '245-248Abstract': [1192], '(130)': [1198], '19Alnemri': [1201], 'Livingston': [1203], 'Nicholson': [1205], 'D.W.': [1206, 1249, 1528], 'Salvesen': [1207, 1303], 'Thornberry': [1209, 1252], 'Wong': [1211], 'W.W.': [1212], 'Yuan': [1213], 'Cell.': [1215, 1307], '87:': [1217], '171Abstract': [1218], '(2146)': [1226], 'Each': [1229], 'cleaves': [1231], 'selectively': [1232], 'subset': [1234], 'cellular': [1236, 2121], 'proteins.': [1237], 'For': [1238, 1487, 1903, 1946], 'instance,': [1239, 1488], 'poly(ADP-ribose)polymerase': [1240], 'preferentially': [1242], '(CPP32/Yama)': [1247], '(20Nicholson': [1248], 'Ali': [1250], 'N.A.': [1253, 1269], 'Vaillancourt': [1254], 'J.P.': [1255], 'Ding': [1256], 'C.K.': [1257], 'Gallant': [1258], 'Gareau': [1260], 'Griffin': [1262], 'P.R.': [1263], 'Labelle': [1264], 'Munday': [1268], 'Raju': [1270], 'S.M.': [1271], 'Smulson': [1272], 'M.E.': [1273], 'Yamin': [1274], 'T.-T.': [1275], 'Yu': [1276], 'V.': [1277], 'Miller': [1278], 'D.K.': [1279], 'Nature.': [1280], '376:': [1282], '37-43Crossref': [1283], '(3796)': [1286], '21Tewari': [1289], 'Quan': [1291], 'L.T.': [1292], "O'Rourke": [1293], 'Desnoyer': [1295], 'Zeng': [1297], 'Z.': [1298], 'Beidler': [1299], 'D.R.': [1300], 'G.S.': [1304], '81:': [1309, 1637, 2041, 3318], '801-809Abstract': [1310], '(2277)': [1316], 'can': [1322], '(Mch-2)': [1328, 4739], 'Interestingly,': [1394, 4673], 'recent': [1395, 3931, 4675, 5082], 'observations': [1396, 3669, 4722], 'demonstrated': [1397, 4698], 'overexpression': [1399, 4700], 'mutant': [1401], 'resistant': [1406], 'delayed': [1410, 4706], 'fragmentation,': [1412, 3145], 'suggesting': [1413], 'participates': [1417], 'activation': [1420, 1490, 3497, 3537, 3974, 4334], '(14Rao': [1427, 4681, 4819, 5093], 'Thus,': [1444, 4490, 5187], 'presently': [1447], 'only': [1449], 'known': [1450, 1453], 'substrates': [1452], 'directly': [1456], 'probably': [1467, 4512], 'regulate': [1470], '(22Gjertsen': [1472], 'B.T.': [1473], 'Doskeland': [1474], 'S.O.': [1475], 'Biochim.': [1476], 'Biophys.': [1477, 1691], 'Acta.': [1478], '1269:': [1480], '187-199Crossref': [1481], '(101)': [1484], 'unscheduled': [1489], 'kinase,': [1493, 4080, 4082], 'one': [1494], 'associated': [1513, 2766, 3261], 'cytotoxic': [1515], 'T': [1516, 4581], 'lymphocyte-mediated': [1517], '(23Shi': [1519], 'Nishioka': [1521], 'W.K.': [1522], "Th'ng": [1523], 'Bradbury': [1525], 'E.M.': [1526], 'Litchfield': [1527], 'Greenberg': [1529], 'A.H.': [1530], 'Science.': [1531], '1143-1145Crossref': [1534], '(572)': [1537], 'precedes': [1541], 'CPT-': [1542], 'damage-induced': [1545], '(24Shimizu': [1550], "O'Connor": [1552, 1612, 2016, 2197, 3040, 3293], 'P.M.': [1553, 4195], 'Kohn': [1554, 1610, 1631, 2014, 2035, 2195, 2214, 3038, 3291, 3312], 'K.W.': [1555, 1611, 1632, 2015, 2036, 2196, 2215, 3039, 3292, 3313], '55:': [1561], '228-231PubMed': [1562], 'present': [1567, 3999, 4144], 'study,': [1568], 'investigated': [1570], 'previously': [1588, 2007, 2190, 3273, 3443], 'described': [1589, 2189, 4529], '25Bertrand': [1606], 'Solary': [1608, 1648, 2012, 2193, 2216, 3007, 3036, 3101, 3289, 4054], 'P.': [1613, 2017, 2198, 3041, 3294, 3701, 4465, 4945], 'Exp.': [1616, 2020, 2201, 3013, 3044, 3061, 3084, 3107, 3297, 3327, 4060, 4566], '211:': [1620, 2024, 2205, 3048, 3301], '314-321Crossref': [1621, 2025, 2206, 3049, 3302], '(471)': [1624, 2028, 2209, 3052, 3305], '26Solary': [1627, 2031, 3308], 'Bertrand': [1629, 2033, 3310], 'Blood.': [1635, 2039, 3316], '1993;': [1636, 2040, 3016, 3110, 3317, 4063, 4346], '1359-1368Crossref': [1638, 2042, 3319], '27Dubrez': [1642], 'Savoy': [1644], 'I.': [1645, 3734, 4170], 'Hamman': [1646], 'EMBO': [1650, 4663], '15:': [1653], '5504-5512Crossref': [1654], '(163)': [1657], 'identity': [1661], 'protease': [1666, 1677, 3457, 3496, 3536, 4930, 4935], 'known.': [1669], 'caspases': [1671], 'candidate': [1682, 4928], '(28Zhivotovsky': [1684], 'Gahm': [1686], 'Orrenius': [1688], 'Biochem.': [1690], 'Commun.': [1693], '233:': [1695], '96-101Crossref': [1696], '(53)': [1699], '29McConkey': [1702], '22398-22406Abstract': [1709], '(UCN-01),': [1722], 'flavopiridol': [1724, 3647, 4218], 'obtained': [1726, 1769], 'NCI': [1729], 'Drug': [1730, 2220], 'Chemistry': [1731], 'Synthesis': [1733], 'Branch.': [1734], 'Drugs': [1735], 'freshly': [1737], 'dissolved': [1738], 'dimethyl': [1740], 'sulfoxide': [1741], '10': [1743, 2116, 2130, 2161, 2600, 2714, 2786, 2819, 2821, 2850, 2872], 'mm': [1744, 1882, 2080, 2083, 2086, 2089, 2092, 2100, 2283, 2366, 2515, 2520, 2697, 2712, 2715, 2721, 2782, 2787, 2795, 2798, 2801, 2804, 2815, 2837], 'further': [1746], 'diluted': [1747], 'water': [1749], 'prior': [1750, 2000], 'each': [1752], 'experiment.': [1753], 'Radiolabeled': [1754], 'precursor': [1755], '[14C]thymidine': [1756, 1912], '(53.6': [1757], 'mCi/mmol)': [1758], 'purchased': [1760, 1777, 1789, 1804, 1821, 1840, 1853], 'NEN': [1762], 'Life': [1763, 1842], 'Science': [1764], 'Products': [1765, 1808], '[32P]orthophosphate': [1767], 'Amersham': [1771, 1855], 'Pharmacia': [1772, 1856], 'Biotech.': [1773, 1857], '3,4-Dichloroisocoumarin': [1774], '(DCI)': [1775], 'Boehringer': [1779], 'Mannheim.': [1780], 'All': [1781, 2296, 2341], 'other': [1782, 1793], 'chemicals': [1783], 'reagent': [1786], 'grade': [1787], 'Sigma': [1791], 'local': [1794], 'sources.': [1795], 'Anti-lamin': [1796], 'monoclonal': [1798, 1831, 3784, 4246], 'mouse': [1801], '(101-B7)': [1802], 'Oncogene': [1806], 'Research': [1807], '(Cambridge,': [1809], 'MA)': [1810, 2434], 'anti-protein': [1812], 'Cα': [1814], '(anti-PKCα)': [1815], 'polyclonal': [1816], 'antibodies': [1817], 'rabbit': [1819], 'Santa': [1823], 'Cruz': [1824], 'Biotechnology': [1825], 'Inc.': [1826, 1844], '(Santa': [1827], 'Cruz,': [1828], 'CA).': [1829, 2415, 2893], 'Anti-PKC': [1830], '1.9': [1833], 'recombinant': [1835], 'baculovirus': [1838], 'Technologies,': [1843, 1879], 'horseradish': [1846], 'peroxidase-conjugated': [1847], 'anti-mouse': [1848], 'immunogloblin': [1849], 'secondary': [1850, 2470], 'Human': [1858], 'promyelocytic': [1859], 'grown': [1864], 'suspension': [1866], 'culture': [1867], 'RPMI': [1869, 1957, 1992, 2491], '1640': [1870, 1958, 1993, 2492], 'medium': [1871, 1926, 1932, 1959, 1970, 2493], 'supplemented': [1872, 2651], '10%': [1874, 1961, 2104, 2373], 'fetal': [1875, 1963], 'calf': [1876, 1964], '(Life': [1878], 'Inc.),': [1880], '2': [1881, 2519, 2757, 2797, 3246], 'glutamine,': [1883], '100': [1884, 1888, 2328], 'units/ml': [1885, 2523], 'penicillin,': [1886], 'μg/ml': [1889, 2512, 2718, 2790, 2825, 2840], 'streptomycin': [1890], '37': [1892], '°C': [1893, 2114, 2398, 2755, 2848, 2904], 'atmosphere': [1896], '95%': [1898], 'air': [1899], '5%': [1901, 2380, 2457], 'CO2.': [1902], 'filter': [1904, 2175, 2186, 2322], 'elution': [1905, 2176, 2187], 'assays,': [1906], 'incubated': [1910, 1972, 2442, 2639, 2744, 2810, 2897, 2928], '1-doubling': [1914], 'time': [1915, 4286], '(about': [1916], '24': [1917], 'h).': [1918], 'cultures': [1920], 'then': [1922, 2403, 3383], 'washed': [1923, 1953, 1986, 2245, 2356, 2488, 2583, 2683, 2770, 2807, 2922], 'fresh': [1925], 'twice': [1927, 1954, 1987, 2777], 'chased': [1929], 'isotope-free': [1931], 'overnight': [1933, 2569, 2938], 'drug': [1935, 2002, 2352, 2481, 2677, 3168], 'treatment.': [1936, 2003, 3169, 3228, 3997], 'Unless': [1937], 'otherwise': [1938], 'indicated,': [1939], 'treatments': [1941], '5': [1944, 2085, 2099, 2261, 2279, 2514, 2711, 2717, 2789, 2828, 3475, 3521], 'μm.': [1945], 'vivo': [1948, 2672], 'phosphorylation,': [1949, 4077, 4267], 'phosphate-free': [1956, 1991, 2490], 'containing': [1960, 2389, 2507], 'dialyzed': [1962, 1995], 'serum,': [1965], 'resuspended': [1966, 1989, 2068, 2360, 2689], 'same': [1969, 2668], '250': [1974], 'μCi': [1975, 2829], '[32P]orthophosphate/107': [1977], 'Following': [1979], '1-h': [1980, 2467], 'incubation,': [1981, 2578, 2648, 2854], '32P-labeled': [1983], '30': [1998, 2741, 2847], 'min': [1999, 2117, 2162, 2401, 2601, 2742], 'followed': [2005, 2275, 2465, 2567, 2725], 'our': [2006, 3340], 'published': [2008], 'procedure': [2009], '(25Bertrand': [2010, 2191, 3034, 3287], 'Briefly,': [2046, 2230], '(5': [2051], 'μmcamptothecin': [2052], 'h)': [2055], 'spun': [2057], 'down,': [2058], 'rinsed': [2059, 2132], 'times': [2061, 2775], 'cold': [2063, 2685], 'PBS': [2064, 2358, 2686], '(phosphate-buffered': [2065], 'saline),': [2066], 'density': [2071, 2149], 'approximately': [2073], '107': [2074], 'cells/ml': [2075], 'nucleus': [2077, 2137, 2250, 2925], 'buffer': [2078, 2138, 2364, 2504, 2566, 2585, 2588, 2649, 2695, 2773, 2780, 2813, 2859, 2926, 2979], '(1': [2079], 'KH2PO4,': [2081], '150': [2082], 'NaCl,': [2084, 2267, 2698], 'MgCl2,': [2087, 2799], 'EGTA,': [2090, 2713], '0.1': [2091], '0.15': [2094], 'unit/ml': [2095], 'aprotinin,': [2096, 2524], '1.0': [2097], 'mmNa3VO4,': [2098, 2518, 2793], 'HEPES,': [2101], 'pH': [2102, 2273, 2285, 2368, 2701, 2784, 2817], '7.4,': [2103, 2785, 2818], 'glycerol),': [2105], 'including': [2106, 2992, 4078, 4532], '0.3%': [2107], 'Triton': [2108, 2140], 'X-100.': [2109], 'After': [2110, 2351, 2416, 2480, 2647, 2676, 2852, 2914, 3406], 'incubation': [2111, 2468, 2728, 3390], '4': [2113, 2522, 2572, 2754, 2903, 2943, 3430], 'gentle': [2119], 'agitation,': [2120], 'mixes': [2122], 'centrifuged': [2124, 2156, 2539], '2,000': [2126], '×': [2127, 2152, 2159, 2329, 2391, 2605, 2635, 2856, 2954], 'g': [2128], 'min,': [2131, 2545], 'once': [2133, 2923], 'centrifugation/resuspension': [2135], 'without': [2139, 2494, 2590], 'X-100,': [2141], 'suspensions': [2146, 2563, 3393], '1–2': [2151], '107nuclei/ml.': [2153], 'Supernatants': [2154], '10,000': [2158, 2953], 'gfor': [2160], 'cytosol.': [2166, 3685, 3832], '[14C]Thymidine-labeled': [2167], 'prepare': [2172], 'assay.': [2177], 'related': [2180, 3763, 5162], 'measured': [2184], '30Bertrand': [2212], 'Dev.': [2221], '34:': [2224], '138-144Crossref': [2225], '(35)': [2227], 'reaction': [2231, 2812, 2866], 'mixtures': [2232], 'deposited': [2234], 'onto': [2235], 'protein-adsorbing': [2236], 'filters': [2237, 2303], '(Metricel,': [2238], 'Gelman': [2239], 'Science,': [2240], 'Ann': [2241], 'Harbor,': [2242], 'MI)': [2243], 'ml': [2248, 2262, 2280], 'buffer.': [2251, 2608], 'This': [2252, 3532, 3822, 4836, 5081], 'fraction': [2253], '(W)': [2254], 'collected.': [2256, 2295], 'Lysis': [2257], 'performed': [2259, 3848], 'LS10': [2264], '(2': [2265], 'm': [2266, 2269, 2371], '0.04': [2268], 'Na2EDTA,': [2270, 2284], '0.2%': [2271], 'Sarkosyl,': [2272], '10)': [2274], 'washing': [2277], '0.02': [2282], '10.': [2286], 'lysis': [2288, 2565, 2694, 2772], '(L)': [2289], 'EDTA': [2291], '(E)': [2292], 'fractions': [2293, 2297], '(W,': [2298], 'L,': [2299], 'E)': [2301], '(F)': [2304], 'counted': [2306], 'liquid': [2308], 'scintillation.': [2309], 'calculated': [2313], 'percent': [2316, 2324], 'eluting': [2319], 'as:': [2323], '=': [2327, 2935], '(W': [2330], '+': [2331, 2333, 2335, 2337, 2339], 'L': [2332, 2336], 'E)/(W': [2334], 'E': [2338], 'F).': [2340], 'experiments': [2342], 'repeated': [2344], 'least': [2346], 'two': [2347, 3147, 4385, 4853, 4974], 'times.': [2350], 'treatment,': [2353, 2678, 3235], 'reducing': [2362], 'loading': [2363, 2607, 2858], '(62.5': [2365], 'Tris-HCl,': [2367, 2783, 2816], '6.8,': [2369], 'urea,': [2372], 'glycerol,': [2374], '2%': [2375], 'SDS,': [2376, 2710], '0.003%': [2377], 'bromphenol': [2378], 'blue,': [2379], '2-mercaptoethanol)': [2381], 'sonicated': [2383], '20': [2385], 's.': [2386], 'lysates': [2388, 2537], '2.5': [2390], '105': [2392], 'heated': [2395], '65': [2397], '15': [2400, 2544], 'loaded': [2404], '12%': [2406, 2613, 2878], 'SDS-polyacrylamide': [2407], 'gels': [2408, 2424, 2616], '(precast': [2409], 'NOVEX,': [2412], 'San': [2413], 'Diego,': [2414], 'electrophoresis,': [2417], 'electrophoretically': [2420], 'transferred': [2421], 'polyvinylidene': [2426], 'difluoride': [2427], 'membranes': [2428], '(Immobilon-P': [2429], 'Millipore': [2431], 'Co.,': [2432], 'Bedford,': [2433], 'according': [2435], "manufacturer's": [2438], 'protocol.': [2439], 'Membranes': [2440], 'room': [2444], 'temperature': [2445], 'solutions': [2453], 'blocking': [2455], 'non-fat': [2458], 'dry': [2459], 'milk': [2460], 'solution': [2461], 'h,': [2464], 'antibody.': [2471, 2982], 'Bands': [2472], 'visualized': [2474], 'enhanced': [2476, 3437], 'chemiluminescence': [2477], '(SuperSignal,': [2478], 'Pierce).': [2479], 'treatment,32P-labeled': [2482], '(107': [2485], 'cells/sample)': [2486], 'once,': [2496, 2687], 'pellets': [2500], 'lysed': [2502], '(PBS': [2506], '1%': [2508, 2526, 2703], 'Nonidet': [2509, 2704], 'P-40,': [2510, 2705], 'leupeptin,': [2513, 2719, 2791], 'NaF,': [2516, 2716, 2788], 'bovine': [2527, 2591], 'albumin)': [2529], '0.4%': [2531, 2653], 'SDS': [2532, 2606, 2654, 2857], 'sonication.': [2534, 2662], '14,500': [2541, 2738], 'rpm': [2542, 2739], 'supernatants': [2548], 'mixed': [2550], '1.5': [2552], 'μg': [2553, 2750], 'anti-human': [2555], '20%': [2560], 'G-Sepharose': [2562, 2747, 2900], 'mixing': [2570], '°C.': [2573, 2944], 'At': [2574], 'immune': [2580, 2595], 'complex': [2581, 2596], 'albumin.': [2593], 'boiled': [2598, 2870], 'adding': [2603], 'Samples': [2609, 2874], 'analyzed': [2611, 2887, 3422], 'SDS-PAGE.': [2614], 'dried': [2618, 2626], 'up': [2619], 'subjected': [2621, 2959], 'autoradiography': [2623, 3424], 'being': [2625, 4042], 'up.': [2627], '(1.5': [2634], '106': [2636], 'nuclei)': [2637], 'presence': [2644, 2834, 3403], '[γ-32P]ATP.': [2646, 3405], 'added': [2656, 2861], 'samples': [2659, 2868, 3412], 'brief': [2661], 'Afterward': [2663], 'procedures': [2665], '(107cells/sample)': [2680], 'harvested,': [2682], '340': [2691], 'μl': [2692], '(150': [2696], '50': [2699], 'mmTris-HCl,': [2700], '8.0,': [2702], '0.5%': [2706], 'sodium': [2707], 'deoxycholate,': [2708], '0.1%': [2709], 'Na3VO4,': [2722], 'mmAEBSF)': [2724], '30-min': [2727], 'ice.': [2730], 'supernatant': [2732, 2957], 'collected': [2734, 2911], 'centrifugation': [2736, 2951], 'anti-PKCα': [2752], 'make': [2760], 'immunoprecipitates.': [2762], 'Sepharose': [2764], 'beads': [2765, 2808, 2901, 2909, 2920, 2946], 'immunoprecipitates': [2768], '(50': [2781], '0.5': [2800, 2803], 'EDTA,': [2802], 'EGTA).': [2805], '(20': [2814], 'mmMgCl2,': [2820], 'μm': [2822, 2844], 'ATP,': [2823], '0.4': [2824], 'histone': [2826, 2883], 'H1,': [2827], '[γ-32P]ATP)': [2831], '1.2': [2836], 'CaCl2,': [2838], '40': [2839], 'phosphatidylserine,': [2841], '3.3': [2843], 'dioleylglycerol': [2845], 'min.': [2851, 2873], 'stop': [2863], 'run': [2876, 3414], 'SDS-PAGE,': [2879, 3416], 'H1': [2884], 'bands': [2885, 3149], 'PhosphorImager': [2889, 3426], '(Molecular': [2890, 3427], 'Dynamics,': [2891], 'Sunnyvale,': [2892], 'Anti-PKCα': [2894], 'h.': [2907], 'centrifugation.': [2913], 'removal': [2915], 'supernatant,': [2918], 'CPT-treated': [2932], '(CPT-cytosol:antibody': [2934], '5:1': [2936], '(v/v))': [2937], 'rotator': [2941], 'subsequently': [2948], 'pelleted': [2949], 'g.': [2955], 'immunoblotting': [2961], 'CPT-cytosol': [2968, 2973], 'immunodepleted': [2969], 'Mock-depleted': [2972], 'made': [2975], 'just': [2976], 'using': [2977], 'replace': [2981], 'remarkably': [2986], 'sensitive': [2987], 'stimuli,': [2991], 'chemotherapeutic': [2993, 4537], 'DNA-damaging': [2994], 'agents': [2995, 4538], '31Bertrand': [3005], 'Jenkins': [3009, 3103, 4056], '207:': [3017, 3111, 4064], '388-397Crossref': [3018, 3066, 3112, 4065], '(132)': [3021, 3115, 4068], 'such': [3024], 'inhibitors': [3033], '32Shao': [3055], 'R.G.': [3056, 3079, 3945, 4292], 'Shimizu': [3057, 3080], '234:': [3065], '(86)': [3069], 'Golgi': [3074], 'poison,': [3075], 'brefeldin': [3076], '(33Shao': [3078], '227:': [3088], '190-196Crossref': [3089], '(104)': [3092], 'Consistent': [3095, 3338], 'previous': [3097, 3341], 'studies': [3098], '(31Bertrand': [3099, 4052], 'shows': [3121, 3431, 3476, 3769, 3867], 'induces': [3124, 3972], 'rapid': [3132], 'kinetics.': [3133], 'similar': [3140], 'kinetics': [3141], '(Fig.': [3150, 3245, 3358, 3376, 3640, 3663, 3839, 3891, 4355, 4399, 4846, 4982, 5060], 'B)': [3152], '45-': [3155], '32-kDa': [3157, 3237, 5018], 'polypeptides': [3158, 4431, 4854, 4975], 'detected': [3161], 'beginning': [3166, 3233, 3994], 'Since': [3170, 5035], 'critical': [3173, 3549, 3919, 4109, 4150], 'modulating': [3175], 'stability': [3177], 'mitosis': [3186, 3554], 'studied': [3203, 3384], 'As': [3212, 3979], '2,': [3216], '69-kDa': [3220], 'polypeptide': [3223, 5030], 'Three': [3229], 'hours': [3230, 4037], 'product': [3241, 3375], 'A).': [3247, 3360, 3642], 'results': [3249, 3910], 'indicate': [3250, 5039], 'occurs': [3255, 5047], 'early': [3256], 'degradation.': [3264, 3507], 'next': [3266, 3509, 4391], 'established': [3274], 'demonstrate': [3276], 'triggering': [3283], '34Shimizu': [3323, 4562], '226:': [3331, 4570], '292-301Crossref': [3332, 4571], '(47)': [3335, 4574], 'results,': [3342], 'Cytosol': [3361], 'naive': [3370], 'B).': [3378, 3841], 'cytosols': [3395], 'control': [3399], 'immunoprecipitation': [3407], 'anti-lamin': [3409], 'antibody,': [3411, 3785], 'Dynamics).': [3428], 'could': [3451, 3515, 3622, 3859], 'DCI': [3459, 3478], 'while': [3477, 4213, 4268], 'blocked': [3479, 4208], 'abolished.': [3490], 'result': [3492], 'required': [3499], 'asked': [3510], 'whether': [3511, 3756, 3851, 3969], 'DCI.': [3519, 3531], 'Cshows': [3522], 'affected': [3529], 'finding': [3533], 'suggests': [3534], 'does': [3538], 'affect': [3540, 4500, 5078], 'Cyclin': [3544], 'B/Cdc2': [3545], '(p34cdc2)': [3546], 'depolymerization': [3552], 'flavopiridol,': [3571], 'potent': [3573], 'Cdk': [3574], '(35Carlson': [3576, 4219], 'Dubay': [3578, 4221], 'M.M.': [3579, 4222], 'Sausville': [3580, 3603, 4196, 4223], 'Brizuela': [3582, 4225], 'Worland': [3584, 3601, 4198, 4227], 'P.J.': [3585, 3602, 4199, 4228], '56:': [3589, 4232], '2973-2978PubMed': [3590, 4233], '36De': [3593], 'Azevedo': [3594], 'Jr.,': [3595, 3805], 'W.F.': [3596], 'Mueller-Dieckmann': [3597], 'H.J.': [3598], 'Schulze-Gahmen': [3599], 'Kim': [3605], '2735-2740Crossref': [3616], '(512)': [3619], 'inhibit': [3624], 'even': [3634], 'high': [3636], 'concentrations': [3637], '(100': [3638], 'μm)': [3639], 'had': [3648], 'effect': [3650], 'either': [3652], '6,': [3664], 'C).': [3667], 'responsible': [3676, 4374], 'phosphorylate': [3694], '(37Collas': [3700, 4464], 'Thompson': [3702, 4466], 'Fields': [3704, 4341, 4468], 'Poccia': [3706, 4470], 'D.L.': [3707, 4471], 'Courvalin': [3708, 4472], 'J.-C.': [3709, 4473], '272:': [3714, 3954, 4301, 4478], '21274-21280Abstract': [3715, 4479], '(60)': [3723, 4487], 'first': [3727, 3990, 4003], 'UCN-01': [3732, 3777, 4168], '(38Takahashi': [3733, 4169], 'Kobayashi': [3735, 4171], 'Asano': [3737, 4173], 'Yoshida': [3739, 4175], 'Nakano': [3741, 4177], 'Antibiot.': [3744, 4180], '(Tokyo).': [3745, 4181], '1987;': [3746, 3810, 4182], '40:': [3747, 4183], '1782-1784Crossref': [3748, 4184], '(205)': [3751, 4187], 'test': [3755, 3850], 'PKC.': [3765, 4254], '7': [3767, 3840, 3865, 3892, 3914], 'dose-dependent': [3780], 'manner.': [3781], 'An': [3782], 'anti-PKC': [3783, 4262], 'acts': [3787], 'near': [3788], 'active': [3790, 4251, 4729], 'inhibits': [3795], 'more': [3799], 'than': [3800], '80%': [3801], '(39Mochly-Rosen': [3802], 'Koshland': [3804], 'D.E.': [3806], '262:': [3811], '2291-2297Abstract': [3812], 'next.': [3821], 'strongly': [3824], 'suppressed': [3825], 'Recombinant': [3833], 'third': [3843], 'type': [3844], 'experiment': [3846], 'extracts': [3858, 4260], 'linked': [3861], 'cytosol,': [3875], 'reduced': [3880], 'about': [3882], '90%.': [3883], 'efficiency': [3885], 'tested': [3890, 3968], 'C,': [3893], 'lower': [3894], 'panel)': [3895], 'showed': [3897, 3933], 'under': [3899], 'condition': [3901], 'almost': [3906], 'undetectable.': [3907], 'Together,': [3908], 'study': [3932, 4000, 4676], '(40Shao': [3944, 4291], 'Cao': [3946, 4293], 'C.X.': [3947, 4294], '31321-31325Abstract': [3955, 4302], '(67)': [3963, 4310], 'Now': [3966], 'whole': [3976], '8,': [3983], 'hour': [3991], 'report': [4004], 'inducer': [4027], '(camptothecin)': [4028], 'persists': [4034], 'several': [4036], 'cleaved,': [4043], 'complete': [4048], 'take': [4050], 'place': [4051], 'Various': [4071], 'PKA': [4084], 'particular,': [4099], 'mitosis,': [4101], 'believed': [4105], 'thus': [4115], 'disassembly': [4116, 4463], 'polymers': [4119], '41Nigg': [4133], '2:': [4139], '261-270PubMed': [4140], 'following': [4162, 4332], 'reasons.': [4163], 'First,': [4164], '42Seynaeve': [4190], 'C.M.': [4191], 'Kazanietz': [4192], 'M.G.': [4193], 'Blumberg': [4194], 'Mol.': [4200], 'Pharmacol.': [4201], '45:': [4203], '1207-1214PubMed': [4204], 'effectively': [4207], 'kinasein': [4211], 'vitro,': [4212], 'cyclin': [4215], 'inactive.': [4237], 'Second,': [4238], 'directed': [4248], 'against': [4249], 'Third,': [4255], 'excess': [4271], 'Fourth': [4277], 'finally,': [4279], 'total': [4280], 'serines': [4325], '395': [4326], '405': [4328], 'bryostatin': [4336], '(43Hocevar': [4337], 'Burns': [4339], '268:': [4347], '7545-7552Abstract': [4348], 'adjacent': [4360], 'highly': [4363, 4380], 'domain,': [4368, 5053], 'thought': [4371], 'formation': [4377], 'stable': [4381], 'coiled-coil': [4382], 'dimer': [4383], 'between': [4384], 'molecules.': [4387], 'It': [4388, 4519], 'translocation': [4395], '(NLS)': [4398], 'case': [4403, 4714], 'chicken': [4405], 'B2,': [4407], 'region': [4413], 'alter': [4418], 'recognition': [4419], 'block': [4424], 'import': [4426], 'newly': [4428], 'synthesized': [4429], 'Recently,': [4445], 'PKC-mediated': [4446, 4491], 'promote': [4456, 5070], 'solubilization': [4459], 'likely': [4498, 5064], 'structure.': [4504], 'Proteolytic': [4505], 'common': [4510], 'functionally': [4513], 'biochemical': [4515], 'feature': [4516], 'all': [4524], 'date,': [4531], '6Shimizu': [4548], 'activation-driven': [4577], 'death': [4579], '(44Ucker': [4583], 'D.S.': [4584], 'Meyers': [4585], 'Obermiller': [4587], 'P.S.': [4588], '149:': [4592], '1583-1592PubMed': [4593], 'thymocyte': [4596], 'inras': [4618], 'drICE': [4653], 'insect': [4655], '(45Fraser': [4657], 'A.G.': [4658], 'McCarthy': [4659], 'N.J.': [4660], 'Evan': [4661], 'G.I.': [4662], '16:': [4666], '6192-6199Crossref': [4667], '(126)': [4670], 'Rao': [4678, 5090], 'et': [4679, 5091, 5112], 'al.': [4680, 5092, 5113], 'p53-dependent': [4716], 'rodent': [4719], 'Caspase': [4737], 'cleave': [4744, 4965], 'aspartic': [4750], 'Asp231': [4818], '9),': [4847, 5061], 'would': [4851, 4961, 5181], 'produce': [4852, 5016], '40.3': [4856, 4873], '25.9': [4858], 'kDa,': [4859, 4980], 'respectively.': [4860], 'correspond': [4869], 'predicted': [4872], 'Another': [4927], 'scaffold': [4934], '(46Clawson': [4936], 'G.A.': [4937], 'Norbeck': [4938], 'L.L.': [4939], 'Hatem': [4940], 'C.L.': [4941], 'Rhodes': [4942], 'C.': [4943], 'Amiri': [4944], 'McKerrow': [4946], 'J.H.': [4947], 'Patierno': [4948], 'S.R.': [4949], 'Fiskum': [4950], 'Growth': [4953], 'Differ.': [4954], '827-838PubMed': [4957], 'expected': [4963], 'tyrosine': [4969], '377': [4970], 'yield': [4973], '43.2': [4977], '23': [4979], 'respectively': [4981], 'Therefore,': [4984], 'it': [4985, 5062, 5188], 'possible': [4987, 5190], 'might': [5005, 5160, 5198], 'sizes': [5038], 'essential': [5056], 'dimerization': [5059], 'should': [5069], 'condensation.': [5080], 'conclusion': [5083], 'consistent': [5085], 'works': [5088], '(12Lazebnik': [5114], 'demonstrating': [5143], 'impairment': [5145], 'condensation': [5149, 5156], 'upon': [5150], 'inhibition': [5151], 'proteolysis.': [5154], 'Chromatin': [5155], 'function': [5166], 'anchorage': [5173], 'regions,': [5179], 'organize': [5182], 'loop': [5185], 'structures.': [5186], 'release': [5193, 5208], 'facilitate': [5199], 'nucleases': [5203], 'loops': [5211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024882180', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T12:46:13.367001', 'created_date': '2016-06-24'}