Title: Neurohormonal prediction of mortality following admission for decompensated heart failure
Abstract: Studies in ambulatory patients with stable congestive heart failure (CHF) have consistently shown that the degree of neurohormonal and cytokine activation provides prognostic information with regard to mortality from progressive CHF, independent of invasive and noninvasive variables that are conventionally used to assess prognosis. 1 Torre-Amione G. Kapadia S. Benedict C. Oral H. Young J.B. Mann D.L. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol. 1996; 27: 1201-1206 Crossref PubMed Scopus (1072) Google Scholar , 2 Pacher R. Stanek B. Hulsmann M. Koller-Strametz J. Berger R. Schuller M. Hartter E. Ogris E. Frey B. Heinz G. Maurer G. Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure. J Am Coll Cardiol. 1996; 27: 633-641 Crossref PubMed Scopus (316) Google Scholar , 3 Benedict C.R. Johnstone D.E. Weiner D.H. Bourassa M.G. Bittner V. Kay R. Kirlin P. Greenberg B. Kohn R.M. Nicklas J.M. Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction a report from the Registry of Studies of Left Ventricular Dysfunction. SOLVD Investigators. J Am Coll Cardiol. 1994; 23: 1410-1420 Crossref PubMed Scopus (216) Google Scholar In the present study, we evaluated neurohormonal and cytokine profiles in patients with decompensated CHF requiring hospitalization. Our aim was to determine whether neurohormonal and cytokine activation in the decompensated state can predict survival after hospital discharge. In addition, we sought to compare neurohormonal and cytokine levels in the decompensated state and during clinical stability after hospital discharge.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 43
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