Publication Information

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'https://openalex.org/W2152058429', 'https://openalex.org/W2154950066', 'https://openalex.org/W2157935345', 'https://openalex.org/W2326807465'], 'related_works': ['https://openalex.org/W4390063994', 'https://openalex.org/W3168207341', 'https://openalex.org/W2620272913', 'https://openalex.org/W2586344792', 'https://openalex.org/W2442596115', 'https://openalex.org/W2084102110', 'https://openalex.org/W2070080810', 'https://openalex.org/W2024420279', 'https://openalex.org/W2002445379', 'https://openalex.org/W1544926311'], 'abstract_inverted_index': {'Although': [0, 175, 1120, 2806, 5539, 6257], 'metal': [1, 60, 125, 131, 148, 164, 176, 235, 300, 306, 323, 339, 618, 628, 931, 944, 1648, 1866, 1891, 1923, 1936, 2128, 2141, 2158, 2166, 2210, 2328, 2582, 2678, 2824, 3061, 3129, 3145, 3159, 3213, 3246, 3283, 3323, 3336, 3347, 3498, 3612, 3670, 4047, 4065, 4174, 4240, 4349, 4358, 4409, 4414, 4430, 4525, 4697, 4766, 5044, 5208, 5220, 5249, 5262, 5506, 5509, 5617, 5701, 5714, 6515, 6539, 6557], 'ions': [2, 149, 177, 324, 932, 945, 1867, 1892, 2142, 2159, 2211, 2329, 2583, 2679, 3214, 3247, 3284, 4066, 4175, 4410, 4415, 4431, 5209, 5263, 5507, 5715, 6540], 'such': [3, 178, 5129, 5716], 'as': [4, 155, 157, 169, 179, 330, 332, 344, 433, 603, 631, 1558, 1812, 1962, 1999, 2118, 2315, 2496, 3751, 3753, 3758, 3760, 3920, 4223, 4444, 4460, 4582, 4692, 4694, 4989, 5320, 5603, 5623, 5717, 5739, 6367, 6369, 6561], 'Cu2+,': [5, 180, 621, 3525, 3576, 4222, 4266], 'Zn2+,': [6, 181, 622, 1847, 1907, 3526, 3577, 4051, 4314, 4994, 5160, 6247, 6434], 'and': [7, 24, 35, 78, 106, 182, 199, 210, 253, 281, 392, 623, 627, 736, 970, 1130, 1189, 1215, 1219, 1719, 1868, 1874, 1896, 1906, 1940, 1984, 2022, 2073, 2115, 2130, 2207, 2228, 2237, 2322, 2354, 2405, 2432, 2468, 2561, 2567, 2601, 2620, 2653, 2671, 2740, 2763, 2778, 2836, 2843, 3185, 3193, 3203, 3264, 3270, 3490, 3519, 3527, 3578, 3779, 3786, 3817, 3866, 4000, 4039, 4050, 4106, 4275, 4501, 4543, 4809, 4816, 4946, 5064, 5081, 5111, 5159, 5181, 5205, 5210, 5329, 5508, 5597, 5631, 5719, 5907, 5939, 5957, 6125, 6255, 6301, 6433, 6464, 6483, 6492, 6550, 6572, 6580], 'Fe3+': [8, 39, 183, 214, 3579, 3731, 3794, 3825, 3858, 3976, 4008, 5540], 'are': [9, 184, 423, 483, 493, 1125, 1416, 2630, 2724, 3064, 4477, 4762, 4874, 5527], 'implicated': [10, 185], 'to': [11, 186, 611, 703, 755, 790, 849, 959, 1195, 1644, 1694, 1720, 1858, 1931, 2077, 2124, 2180, 2242, 2314, 2356, 2381, 2455, 2461, 2480, 3199, 3291, 3332, 3361, 3472, 3478, 3509, 3566, 3614, 3643, 3662, 3802, 4030, 4099, 4136, 4141, 4210, 4261, 4268, 4298, 4302, 4319, 4336, 4372, 4381, 4488, 4497, 4580, 4680, 4723, 4730, 4748, 4940, 4985, 5023, 5073, 5098, 5327, 5629, 5724, 5894, 5960, 6012, 6041, 6119, 6330, 6342, 6359, 6371, 6412], 'play': [12, 187], 'a': [13, 81, 188, 256, 379, 426, 850, 955, 1489, 1559, 1646, 1813, 1963, 2078, 2119, 2225, 2257, 2268, 2421, 2462, 2474, 2610, 2621, 3604, 3714, 3806, 3945, 3954, 4090, 4583, 4819, 4924, 5106, 5580, 5740, 6364], 'key': [14, 189, 4513], 'role': [15, 20, 190, 195, 616, 929, 1888, 5259, 5504, 6329, 6535], 'in': [16, 47, 150, 191, 222, 325, 608, 625, 699, 708, 743, 794, 845, 852, 895, 1127, 1192, 1423, 1724, 1730, 1842, 1919, 1989, 2033, 2037, 2060, 2071, 2097, 2143, 2176, 2196, 2301, 2319, 2364, 2458, 2558, 2573, 2665, 2668, 2672, 2783, 2839, 2849, 3066, 3169, 3181, 3186, 3222, 3232, 3285, 3294, 3308, 3326, 3344, 3481, 3504, 3559, 3587, 3717, 3809, 3819, 3840, 3913, 3922, 3935, 3972, 3989, 4032, 4057, 4097, 4256, 4340, 4346, 4374, 4438, 5031, 5059, 5075, 5086, 5134, 5202, 5257, 5264, 5512, 5532, 5547, 5625, 5884, 6034, 6291, 6416, 6462, 6510, 6520, 6532, 6541, 6548], 'Alzheimer': [17, 85, 173, 192, 260, 348, 350, 358, 1967], 'disease,': [18, 86, 193, 261], 'their': [19, 194, 1193, 1869, 1990, 3170, 3249], 'is': [21, 27, 196, 202, 378, 933, 937, 946, 1488, 1556, 1641, 1856, 2379, 3297, 3329, 3359, 3476, 3501, 3507, 3564, 4067, 4134, 4207, 4259, 4405, 4411, 4520, 4848, 4860, 4961, 4970, 5048, 5054, 5167, 5248, 5541, 5696, 5927, 6038, 6283, 6355, 6460], 'rather': [22, 197, 934], 'complex,': [23, 198, 5186, 5190], 'comprehensive': [25, 200, 1860], 'understanding': [26, 201, 1861, 5501, 6533], 'not': [28, 38, 93, 203, 213, 268, 938, 1849, 1909, 2134, 2186, 2811, 3143, 3165, 3216, 3330, 3545, 3555, 3648, 3685, 3709, 3733, 3763, 3849, 3857, 3987, 4007, 4084, 4208, 4231, 4317, 4356, 4436, 4450, 4707, 4745, 4864, 5011, 5027, 5127, 5188, 5224, 5229, 5536, 5578, 5606, 5899, 6039, 6265, 6284, 6356, 6436, 6511], 'yet': [29, 204, 612], 'obtained.': [30, 205], 'We': [31, 206, 1927, 2132, 3570, 3765, 4070, 4167, 4363, 6286, 6429], 'show': [32, 207, 892, 1903, 4508], 'that': [33, 109, 208, 284, 1904, 3060, 3157, 3211, 3237, 3277, 3318, 3363, 3465, 3484, 3497, 4045, 4333, 4365, 4402, 4412, 4509, 4850, 4929, 4960, 4971, 5077, 5082, 5163, 5219, 5238, 5518, 5591, 5697, 5888, 5918, 6261, 6288, 6431, 6453, 6465], 'Cu2+': [34, 209, 698, 733, 752, 786, 854, 896, 969, 1129, 1188, 1214, 1845, 1905, 2057, 2766, 2804, 2842, 3196, 3263, 3289, 3551, 3596, 3616, 3693, 3746, 3792, 3853, 3865, 3993, 4003, 4049, 4074, 4142, 4198, 4334, 4382, 4480, 4542, 4817, 4883, 5146, 5328, 5596, 5718, 6300, 6339, 6432], 'Zn2+': [36, 107, 211, 282, 737, 971, 1131, 1190, 1216, 2059, 2762, 2844, 3192, 3265, 3553, 3711, 3748, 3855, 3867, 3995, 4005, 4366, 4378, 4544, 4756, 4815, 4873, 4943, 5035, 5063, 5090, 5112, 5330, 5598, 5720, 5908, 5954, 5966, 6302, 6376, 6502], 'but': [37, 92, 212, 267, 1908, 3856, 4006, 4089, 4355, 4479, 4549, 4744, 5187, 5898, 6264, 6435, 6518], 'renders': [40, 215], 'the': [41, 73, 90, 94, 124, 136, 145, 161, 216, 248, 265, 269, 299, 311, 320, 336, 498, 501, 600, 636, 706, 744, 748, 928, 941, 947, 950, 963, 1419, 1424, 1550, 1698, 1732, 1808, 1837, 1863, 1872, 1882, 1887, 1894, 1933, 1943, 1951, 1957, 1974, 2034, 2038, 2061, 2098, 2103, 2107, 2125, 2136, 2140, 2149, 2153, 2157, 2161, 2165, 2171, 2181, 2220, 2320, 2346, 2382, 2407, 2428, 2434, 2438, 2443, 2456, 2469, 2562, 2565, 2574, 2602, 2631, 2669, 2673, 2696, 2732, 2769, 2784, 2799, 2803, 2817, 2823, 2828, 2852, 3158, 3187, 3212, 3229, 3238, 3241, 3252, 3260, 3267, 3274, 3278, 3292, 3301, 3319, 3333, 3342, 3346, 3373, 3379, 3466, 3469, 3473, 3487, 3511, 3516, 3529, 3538, 3568, 3573, 3581, 3598, 3611, 3618, 3622, 3625, 3630, 3636, 3652, 3657, 3663, 3666, 3669, 3678, 3688, 3695, 3719, 3728, 3735, 3769, 3775, 3780, 3783, 3787, 3803, 3820, 3831, 3860, 3869, 3933, 3936, 3973, 3990, 4010, 4017, 4036, 4040, 4046, 4054, 4064, 4073, 4112, 4117, 4120, 4170, 4173, 4177, 4187, 4192, 4195, 4205, 4211, 4216, 4219, 4224, 4235, 4239, 4246, 4250, 4262, 4272, 4276, 4282, 4285, 4291, 4311, 4322, 4329, 4337, 4344, 4348, 4357, 4384, 4393, 4397, 4408, 4413, 4417, 4422, 4425, 4429, 4442, 4455, 4463, 4466, 4471, 4482, 4491, 4512, 4516, 4521, 4533, 4546, 4682, 4687, 4696, 4701, 4709, 4724, 4733, 4740, 4751, 4851, 4856, 4930, 4935, 4947, 4954, 4972, 4995, 4999, 5016, 5019, 5024, 5032, 5037, 5041, 5051, 5055, 5060, 5066, 5079, 5084, 5087, 5093, 5102, 5114, 5122, 5135, 5142, 5153, 5164, 5170, 5179, 5192, 5199, 5203, 5239, 5244, 5258, 5500, 5503, 5519, 5584, 5611, 5634, 5705, 5709, 5713, 5889, 5914, 5924, 5930, 5937, 5949, 5961, 6013, 6017, 6029, 6042, 6148, 6163, 6166, 6170, 6173, 6233, 6262, 6266, 6271, 6277, 6289, 6292, 6297, 6336, 6345, 6351, 6360, 6375, 6406, 6409, 6417, 6422, 6440, 6450, 6454, 6458, 6466, 6470, 6478, 6490, 6496, 6514, 6522, 6534, 6537, 6554], 'amyloid': [42, 153, 217, 328, 361, 364, 388, 502, 605, 1420, 1838, 1875, 2408, 2483, 3582, 3720, 3777, 4689, 5728, 5901, 6418, 6441, 6542], 'β': [43, 218], 'peptide,': [44, 219, 2829, 4949, 5635, 6424], 'Aβ1–40,': [45, 220, 2820, 2848, 3615, 6275], 'nonfibrillogenic': [46, 221, 5531], 'nature.': [48, 223], 'However,': [49, 224, 1833, 3255, 3656, 3981, 4419, 5943], 'preformed': [50, 225], 'fibrils': [51, 226, 2339, 2484, 3872, 4423, 4443, 4476], 'of': [52, 65, 89, 98, 104, 128, 147, 163, 227, 240, 264, 273, 279, 303, 322, 338, 386, 425, 428, 488, 497, 599, 617, 638, 705, 732, 747, 841, 930, 943, 952, 962, 1221, 1485, 1491, 1552, 1697, 1734, 1810, 1862, 1878, 1889, 1899, 1935, 1946, 1954, 1960, 2020, 2029, 2042, 2056, 2081, 2121, 2139, 2156, 2164, 2174, 2183, 2192, 2219, 2293, 2295, 2324, 2327, 2345, 2359, 2384, 2417, 2430, 2437, 2465, 2552, 2564, 2578, 2581, 2661, 2675, 2738, 2747, 2771, 2773, 2786, 2802, 2819, 2827, 2847, 3132, 3148, 3179, 3189, 3220, 3240, 3244, 3262, 3273, 3322, 3335, 3375, 3468, 3515, 3524, 3532, 3537, 3541, 3575, 3585, 3610, 3621, 3624, 3665, 3675, 3691, 3723, 3738, 3745, 3771, 3782, 3799, 3805, 3822, 3863, 3932, 3938, 3967, 3975, 3983, 3992, 4012, 4035, 4063, 4081, 4111, 4119, 4132, 4172, 4180, 4186, 4194, 4204, 4215, 4226, 4238, 4249, 4253, 4265, 4281, 4295, 4310, 4321, 4324, 4352, 4387, 4396, 4421, 4424, 4441, 4457, 4462, 4470, 4511, 4524, 4530, 4684, 4700, 4712, 4719, 4726, 4732, 4742, 4750, 4822, 4853, 4855, 4869, 4934, 4942, 4956, 4958, 4998, 5021, 5034, 5040, 5043, 5062, 5078, 5083, 5089, 5095, 5101, 5109, 5117, 5132, 5137, 5145, 5157, 5173, 5176, 5198, 5207, 5241, 5260, 5502, 5505, 5525, 5587, 5595, 5616, 5633, 5708, 5712, 5891, 5896, 5904, 5913, 5920, 5934, 5951, 5953, 5965, 5968, 6016, 6022, 6032, 6172, 6236, 6268, 6274, 6296, 6299, 6335, 6338, 6344, 6350, 6374, 6378, 6408, 6421, 6444, 6457, 6469, 6495, 6501, 6525, 6536, 6545, 6556], 'Aβ1–40': [53, 66, 129, 228, 241, 304, 1912, 1970, 2032, 2195, 2300, 2555, 2664, 2774, 3133, 3149, 3163, 3180, 3221, 3586, 3724, 3739, 3800, 3910, 4031, 4082, 4181, 4254, 4299, 4325, 4373, 4388, 4496, 4713, 4728, 4959, 5118, 5526, 5958, 6237], 'were': [54, 229, 1987, 2063, 2086, 2212, 2330, 2348, 2440, 2590, 2594, 2607, 2640, 2684, 2729, 3197, 6157], 'stable': [55, 230, 4478, 4877], 'when': [56, 231, 4878], 'treated': [57, 232], 'with': [58, 140, 233, 315, 972, 1844, 1865, 2240, 2335, 2413, 2598, 2616, 2650, 2851, 3251, 3281, 3743, 3791, 3953, 4016, 4053, 4369, 4428, 4545, 4550, 4813, 4818, 4872, 4880, 4882, 5733, 6122, 6246, 6503], 'these': [59, 234, 3245, 3282, 3314, 4987, 6023], 'ions.': [61, 236, 2167, 4526], 'Consequently,': [62, 237], 'fibril': [63, 96, 114, 137, 238, 271, 289, 312, 1839, 1876, 1944, 2409, 2568, 3268, 3583, 3599, 3626, 3631, 3645, 3658, 3696, 3702, 3721, 3736, 3773, 3838, 3861, 3939, 4020, 4037, 4353, 4385, 4403, 4458, 4472, 4483, 4492, 4518, 4690, 4702, 4710, 4735, 4752, 4858, 4965, 4980, 4996, 5017, 5067, 5103, 5115, 5148, 5183, 5193, 5245, 5608, 5706, 5729, 5902, 5915, 5921, 5941, 6126, 6155, 6251, 6272, 6281, 6419, 6442, 6467, 6497, 6523, 6543], 'growth': [64, 97, 138, 239, 272, 313, 1945, 3269, 3584, 3600, 3627, 3646, 3659, 3697, 3703, 3722, 3737, 3798, 3862, 4021, 4038, 4354, 4386, 4404, 4493, 4519, 4691, 4711, 4736, 4753, 4859, 4997, 5068, 5116, 5149, 5246, 5707, 5903, 5922, 6252, 6273, 6420, 6443, 6468, 6524], 'could': [67, 242, 3235, 3835, 4927], 'be': [68, 243, 1645, 3048, 3200, 3236, 4137, 4303, 4678, 4928, 5071, 5074, 5601, 5638, 6120, 6159, 6473], 'switched': [69, 244, 6474], 'on/off': [70, 245, 4490, 6475], 'by': [71, 246, 383, 485, 2102, 2693, 3050, 3300, 3672, 3767, 4023, 4076, 4218, 4407, 4446, 4494, 4755, 5046, 5231, 5721, 5923, 6476], 'switching': [72, 247, 4495, 6477], 'molecule': [74, 249, 6366, 6411, 6479], 'between': [75, 250, 4271, 4944, 5076, 5955, 6480], 'its': [76, 251, 1834, 2712, 2831, 3755, 3923, 4498, 6481], 'apo-': [77, 252, 4500, 6482], 'holo-forms.': [79, 254, 6484], 'Clioquinol,': [80, 255], 'potential': [82, 170, 257, 345, 1560, 1814, 1964, 4584, 5741, 6562], 'drug': [83, 258, 1815, 1965, 4585, 5742], 'for': [84, 172, 259, 347, 1562, 1728, 1966, 2050, 2092, 2214, 2230, 2587, 2689, 2711, 3228, 3633, 3941, 3950, 4399, 4465, 4586, 4964, 5169, 5727, 5929, 6028, 6449, 6564, 6578, 6584], 'induced': [87, 262], 'resumption': [88, 263, 4731, 4749, 4854, 5895], 'Cu2+-suppressed': [91, 266, 5897], 'Zn2+-suppressed': [95, 270, 4857, 5182, 5900, 5940], 'Aβ1–40.': [99, 274, 1900, 1947, 3522, 3864, 5588, 5710, 5905, 6445, 6526], 'The': [100, 275, 421, 615, 965, 1636, 1901, 1948, 2053, 2084, 2245, 2264, 2284, 2477, 2627, 2703, 2717, 2726, 2780, 3052, 3175, 4079, 4108, 4129, 4183, 4308, 4506, 4717, 4967, 5692, 6332], 'observed': [101, 276, 3320, 3649, 3653, 4202, 4255, 4467, 5154, 5171, 5931, 6293], 'synergistic': [102, 277, 5107, 5130, 5155, 5911], 'effect': [103, 278, 1835, 2429, 2815, 3716, 4171, 4978, 5014, 5030, 5108, 5131, 5144, 5156, 5240, 5582], 'clioquinol': [105, 117, 280, 292, 1638, 1961], 'suggests': [108, 283], 'Zn2+-clioquinol': [110, 285], 'complex': [111, 286, 4937, 4974, 5926, 6337, 6377, 6410], 'effectively': [112, 287], 'retards': [113, 135, 288, 310, 5191, 6270], 'growth.': [115, 290, 4473, 4703, 4966, 4981, 5194, 5730, 5942, 6498], 'Thus,': [116, 291, 927, 2838, 3207, 3311, 3852, 4002, 4245, 4328, 5234], 'has': [118, 293, 634, 787, 1691, 1806, 1848, 4577, 5252, 6116], 'dual': [119, 294, 1952, 6507], 'effects;': [120, 295], 'although': [121, 296, 6165], 'it': [122, 133, 297, 308, 936, 1855, 2074, 2821, 3340, 3358, 4485, 4847, 5161, 5576, 5604, 6248], 'disaggregates': [123, 298], 'ion-induced': [126, 301, 1924, 2825, 3062, 3130, 3146, 3324, 3499, 4350, 4359, 4698], 'aggregates': [127, 302, 1487, 3063, 5228, 6174, 6235, 6517], 'through': [130, 305, 6426], 'chelation,': [132, 307], 'further': [134, 309, 3298, 4071, 5099], 'along': [139, 314, 3790, 6245], 'Zn2+.': [141, 316, 4866], 'These': [142, 317, 2592], 'results': [143, 318, 1723, 1902, 1949, 3258, 4507, 5236, 5738, 6259], 'indicate': [144, 319, 3276], 'mechanism': [146, 321, 1959], 'suppressing': [151, 326], 'Aβ': [152, 327, 481, 601, 792, 843, 966, 1222, 1879, 3253, 3376, 3470, 3542, 3776, 3784, 4055, 4338, 4426, 4517, 4688, 4948, 5200, 5321, 6037, 6423, 6546], 'formation,': [154, 329, 1840, 6156], 'well': [156, 331, 3752, 3875, 4693, 4763, 6368], 'providing': [158, 333, 3629], 'information': [159, 334, 6552], 'toward': [160, 335, 3378, 5499], 'use': [162, 337, 1551, 6031, 6555], 'ion': [165, 340, 629, 1649, 1937, 2129, 3337, 3613, 4241, 4767, 5510, 5618], 'chelators,': [166, 341, 1938, 6558], 'particularly': [167, 342, 6559], 'clioquinol,': [168, 343], 'drugs': [171, 346, 6563], 'disease.': [174, 349, 964, 1968], 'disease': [351, 381, 707], '(AD)': [352], '1The': [353], 'abbreviations': [354], 'used': [355, 1928, 4242], 'are:': [356], 'AD,': [357], 'disease;': [359], 'Aβ,': [360], 'β;': [362], 'APP,': [363], 'precursor': [365, 503], 'protein;': [366], 'CQ,': [367, 1941, 1955, 2433, 4537, 4746, 5065, 6269, 6560], 'clioquinol;': [368], 'ThT,': [369], 'thioflavin': [370, 2362], 'T;': [371], 'TIRFM,': [372], 'total': [373], 'internal': [374], 'reflection': [375], 'fluorescence': [376, 2424, 3302, 4025, 4077, 4110, 4118, 4131, 4179, 4184, 4206, 4217, 4225, 4252, 4286, 4323, 4330], 'microscopy.': [377], 'neurodegenerative': [380], 'characterized': [382], 'cerebral': [384], 'deposits': [385, 396, 422, 606, 793, 1696, 1735], 'extracellular': [387, 751], 'plaques,': [389], 'intracellular': [390], 'tangles,': [391], 'intravascular': [393], 'or': [394, 949, 954, 1846, 1915, 2040, 2058, 2147, 2576, 2680, 2757, 3161, 3352, 3552, 3641, 3747, 3793, 3846, 3854, 3994, 4004, 4370, 4721, 5523, 5530, 6414], 'extravascular': [395], '(1Hardy': [397], 'J.': [398, 511, 538, 576, 768, 873, 904, 991, 1002, 1044, 1069, 1089, 1140, 1233, 1290, 1318, 1342, 1376, 1405, 1445, 1474, 1680, 2509, 2539, 2864, 2921, 2949, 2973, 3007, 3036, 3089, 3118, 3421, 3448, 4151, 4798, 4913, 5347, 5358, 5400, 5425, 5445, 5560, 6000], 'Selkoe': [399, 583], 'D.J.': [400, 411], 'Science.': [401, 412, 528, 1263, 1509, 2894, 3400, 5654, 6058, 6189], '2002;': [402, 670, 876, 3882, 5293], '297:': [403], '353-356Crossref': [404], 'PubMed': [405, 416, 448, 476, 532, 593, 655, 673, 692, 725, 779, 834, 884, 922, 996, 1019, 1055, 1078, 1100, 1115, 1151, 1166, 1183, 1209, 1242, 1267, 1301, 1323, 1353, 1387, 1410, 1456, 1479, 1513, 1542, 1583, 1631, 1669, 1714, 1748, 1800, 1828, 2400, 2520, 2545, 2873, 2898, 2932, 2954, 2984, 3018, 3041, 3100, 3123, 3404, 3426, 3459, 3890, 3905, 4162, 4572, 4600, 4623, 4671, 4787, 4842, 4902, 5278, 5296, 5315, 5352, 5375, 5411, 5434, 5456, 5471, 5488, 5571, 5658, 5687, 5755, 5778, 5826, 5878, 5989, 6062, 6091, 6110, 6142, 6193, 6222, 6321, 6398], 'Scopus': [406, 417, 449, 477, 533, 555, 594, 656, 674, 693, 726, 780, 835, 885, 923, 997, 1020, 1056, 1101, 1116, 1152, 1167, 1184, 1210, 1268, 1302, 1324, 1354, 1388, 1411, 1457, 1480, 1514, 1543, 1584, 1632, 1670, 1687, 1715, 1749, 1801, 1829, 2401, 2521, 2546, 2899, 2933, 2955, 2985, 3019, 3042, 3101, 3124, 3405, 3427, 3460, 3891, 3906, 4163, 4573, 4601, 4624, 4672, 4788, 4805, 4843, 4903, 4920, 5279, 5297, 5316, 5353, 5376, 5412, 5457, 5472, 5489, 5572, 5659, 5688, 5756, 5779, 5827, 5879, 5990, 6007, 6063, 6092, 6111, 6143, 6194, 6223, 6322, 6399], '(11361)': [407], 'Google': [408, 419, 451, 479, 535, 557, 596, 658, 676, 695, 728, 782, 837, 887, 925, 999, 1022, 1058, 1079, 1103, 1118, 1154, 1169, 1186, 1212, 1243, 1270, 1304, 1326, 1356, 1390, 1413, 1459, 1482, 1516, 1545, 1586, 1634, 1672, 1689, 1717, 1751, 1803, 1831, 2403, 2523, 2548, 2874, 2901, 2935, 2957, 2987, 3021, 3044, 3103, 3126, 3407, 3429, 3462, 3893, 3908, 4165, 4575, 4603, 4626, 4674, 4790, 4807, 4845, 4905, 4922, 5281, 5299, 5318, 5355, 5378, 5414, 5435, 5459, 5474, 5491, 5574, 5661, 5690, 5758, 5781, 5829, 5881, 5992, 6009, 6065, 6094, 6113, 6145, 6196, 6225, 6324, 6401], 'Scholar,': [409, 452, 536, 558, 659, 677, 1000, 1023, 1059, 1080, 1104, 1155, 1170, 1244, 1271, 1305, 1327, 1357, 1391, 1460, 1517, 1587, 1673, 1752, 2524, 2875, 2902, 2936, 2958, 2988, 3022, 3104, 3408, 3894, 4604, 4627, 4791, 4906, 5282, 5300, 5356, 5379, 5415, 5436, 5460, 5475, 5662, 5759, 5782, 5830, 5993, 6066, 6095, 6197], '2Selkoe': [410], '1997;': [413, 1345, 2976, 3451], '275:': [414], '630-631Crossref': [415], '(860)': [418], 'Scholar).': [420, 480, 597, 696, 729, 783, 838, 888, 926, 1119, 1213, 1483, 1546, 1635, 1804, 1832, 2549, 3127, 3430, 3909, 4166, 4675, 5492, 5691, 5882, 6114, 6146, 6226], 'comprised': [424], 'mixture': [427], '39–43-amino-acid': [429], 'polypeptides': [430], 'generally': [431], 'designated': [432], 'amyloid-β': [434], '(Aβ)': [435], 'peptide': [436, 2150, 2556, 2566, 3275, 3279, 3293, 3349, 3377, 3471, 3785, 3934, 4056, 4113, 4188, 4339, 4427, 5000, 5201, 6459, 6471], '(3Glenner': [437], 'G.G.': [438], 'Wong': [439], 'C.W.': [440, 1506, 1589, 4629, 5651, 5784, 6055, 6186], 'Biochem.': [441, 1406, 1475, 2396, 3037, 3119], 'Biophys.': [442, 3901], 'Res.': [443, 918], 'Commun.': [444], '1984;': [445], '120:': [446], '885-890Crossref': [447], '(4403)': [450], '4Masters': [453], 'C.L.': [454, 868, 914, 1039, 1260, 1625, 1788, 2891, 3397, 4665, 5395, 5820, 5866], 'Simms': [455], 'G.': [456, 460, 823, 910, 1012, 1108, 1159, 1250, 2881, 3387, 5368, 5464], 'Weinman': [457], 'N.A.': [458], 'Multhaup': [459, 822, 909, 1249, 2880, 3386], 'Mc': [461], 'Donald': [462], 'B.L.': [463], 'Beyreuther': [464, 865, 911, 1034, 1257, 1620, 1781, 2888, 3394, 4660, 5390, 5815, 5859], 'K.': [465, 813, 866, 912, 1035, 1174, 1200, 1258, 1361, 1430, 1527, 1531, 1621, 1782, 2390, 2504, 2534, 2889, 2992, 3074, 3395, 4661, 5391, 5479, 5672, 5676, 5816, 5860, 6076, 6080, 6207, 6211], 'Proc.': [466, 545, 715, 824, 1532, 5677, 6081, 6100, 6132, 6212], 'Natl.': [467, 546, 716, 825, 1533, 5678, 6082, 6101, 6133, 6213], 'Acad.': [468, 547, 717, 826, 1534, 1578, 4618, 5679, 5773, 6083, 6102, 6134, 6214], 'Sci.': [469, 548, 718, 770, 827, 1535, 1579, 4619, 5562, 5680, 5774, 6084, 6103, 6135, 6215], 'U.': [470, 549, 719, 828, 1536, 5681, 6085, 6104, 6136, 6216], 'S.': [471, 515, 527, 550, 572, 720, 801, 829, 1369, 1438, 1523, 1537, 1595, 1619, 2530, 3000, 3082, 4635, 4659, 5668, 5682, 5790, 5814, 6072, 6086, 6105, 6137, 6203, 6217], 'A.': [472, 551, 661, 721, 803, 805, 811, 830, 1375, 1444, 1525, 1538, 1593, 1607, 3006, 3088, 3224, 3287, 4633, 4647, 5284, 5670, 5683, 5788, 5802, 6074, 6087, 6097, 6106, 6129, 6138, 6205, 6218], '1985;': [473], '82:': [474, 1685, 4803, 4918, 6005], '4245-4249Crossref': [475], '(3808)': [478], 'peptides': [482, 602, 844, 967, 1223, 3543, 5322, 6547], 'secreted': [484], 'proteolytic': [486], 'processing': [487], 'several': [489], 'membrane': [490], 'proteins,': [491], 'which': [492, 1415, 1640, 1920, 2378, 3046, 3345, 4347, 4538, 4950, 5534, 5636, 6403], 'alternative': [494], 'splicing': [495], 'products': [496], 'gene': [499], 'coding': [500], 'protein': [504, 2109, 2704], '(APP)': [505], '(5Shoji': [506], 'M.': [507, 566, 574, 821, 1252, 1367, 1436, 1519, 1521, 1597, 1615, 1653, 2392, 2528, 2883, 2998, 3080, 3389, 3896, 4556, 4637, 4655, 4771, 4826, 4886, 5664, 5666, 5792, 5810, 5973, 6068, 6070, 6199, 6201, 6305, 6382], 'Golde': [508], 'T.': [509, 513, 807, 1172, 1198, 1365, 1434, 2394, 2500, 2526, 2996, 3078, 5477, 6570], 'Ghiso': [510], 'Cheung': [512], 'Estus': [514], 'Shaffer': [516], 'L.': [517, 1599, 1601, 1659, 4562, 4639, 4641, 4777, 4832, 4892, 5794, 5796, 5979, 6311, 6388], 'Cai': [518], 'X.': [519, 980, 1277, 1329, 1371, 1440, 1570, 1774, 2908, 2960, 3002, 3084, 3435, 4610, 5336, 5765, 5852], 'McKay': [520], 'D.': [521, 540, 570, 584, 588, 819, 1395, 1464, 1609, 1617, 2502, 2532, 3026, 3108, 4649, 4657, 5804, 5812], 'Tintner': [522], 'R.': [523, 580, 582, 809, 858, 900, 916, 1496, 1603, 3880, 4643, 5641, 5798, 6045, 6176], 'Frangione': [524], 'B.': [525, 544, 1661, 4564, 4779, 4834, 4894, 5981, 6313, 6390, 6566], 'Younkin': [526], '1992;': [529, 590], '258:': [530], '126-129Crossref': [531], '(1334)': [534], '6Busciglio': [537], 'Gabuzda': [539], 'Matsudaira': [541], 'P.': [542, 560, 1657, 1663, 4560, 4566, 4775, 4781, 4830, 4836, 4890, 4896, 5977, 5983, 6309, 6315, 6386, 6392], 'Yankner': [543, 6098, 6130], '1993;': [552], '90:': [553], '2090-2096Crossref': [554], '(537)': [556], '7Seubert': [559], 'Vigo-Pelfrey': [561], 'C.': [562, 578, 665, 817, 1611, 1655, 4558, 4651, 4773, 4828, 4888, 5288, 5806, 5975, 6307, 6384], 'Esch': [563], 'F.': [564, 1027, 5383], 'Lee': [565], 'Dovey': [567], 'H.': [568, 906, 1178, 1204, 1784, 2388, 2506, 2536, 5483, 5862], 'Davis': [569, 1618, 4658, 5813], 'Sinha': [571], 'Schlossmacher': [573], 'Whaley': [575], 'Swindlehurst': [577], 'McCormack': [579], 'Wolfert': [581], 'Lieberberg': [585], 'I.': [586, 860, 1029, 1613, 1768, 4653, 5385, 5808, 5846], 'Schenk': [587], 'Nature.': [589], '359:': [591], '325-327Crossref': [592], '(1633)': [595], 'Accumulation': [598], 'insoluble': [604], 'occurs': [607], 'AD': [609, 626, 953, 1564, 1699, 1729, 4587, 5265, 5548, 6549], 'due': [610, 2179, 3331, 4209, 4260, 5959, 6358, 6370], 'unclear': [613], 'mechanism(s).': [614], 'ions,': [619, 4048], 'notably': [620], 'Fe3+,': [624, 1910, 6437], 'chelators': [630, 2439, 4768, 5511], 'therapeutic': [632, 6030], 'agents': [633], 'been': [635, 741, 788, 1692, 1807, 1850, 3546, 4578, 5253, 6117], 'subject': [637], 'interest': [639, 5256], 'over': [640], 'recent': [641, 1492], 'years': [642], '(8Bush': [643, 1702, 1736, 1816, 4588, 5266, 5743], 'A.I.': [644, 870, 908, 990, 1041, 1061, 1225, 1246, 1289, 1341, 1574, 1591, 1703, 1737, 1790, 1817, 2856, 2877, 2920, 2972, 3383, 3447, 4589, 4614, 4631, 5267, 5346, 5397, 5417, 5744, 5769, 5786, 5868], 'Trends': [645, 1704, 1738, 1818, 4590, 5268, 5745], 'Neurosci.': [646, 1705, 1739, 1819, 4591, 5269, 5746], '2003;': [647, 722, 831, 1016, 1407, 1476, 1510, 1539, 1628, 1706, 1740, 1820, 2512, 3038, 3120, 4592, 4668, 5270, 5372, 5655, 5684, 5747, 5823, 6059, 6088, 6190, 6219], '26:': [648, 1707, 1741, 1821, 4593, 5271, 5748], '207-214Abstract': [649, 1708, 1742, 1822, 4594, 5272, 5749], 'Full': [650, 652, 687, 689, 774, 776, 879, 881, 1050, 1052, 1075, 1095, 1097, 1146, 1148, 1239, 1296, 1298, 1348, 1350, 1382, 1384, 1451, 1453, 1709, 1711, 1743, 1745, 1795, 1797, 1823, 1825, 2515, 2517, 2870, 2927, 2929, 2979, 2981, 3013, 3015, 3095, 3097, 3454, 3456, 3885, 3887, 4157, 4159, 4595, 4597, 5273, 5275, 5310, 5312, 5406, 5408, 5431, 5451, 5453, 5566, 5568, 5750, 5752, 5873, 5875], 'Text': [651, 653, 688, 690, 775, 777, 880, 882, 1051, 1053, 1076, 1096, 1098, 1147, 1149, 1240, 1297, 1299, 1349, 1351, 1383, 1385, 1452, 1454, 1710, 1712, 1744, 1746, 1796, 1798, 1824, 1826, 2516, 2518, 2871, 2928, 2930, 2980, 2982, 3014, 3016, 3096, 3098, 3455, 3457, 3886, 3888, 4158, 4160, 4596, 4598, 5274, 5276, 5311, 5313, 5407, 5409, 5432, 5452, 5454, 5567, 5569, 5751, 5753, 5874, 5876], 'PDF': [654, 691, 778, 883, 1054, 1077, 1099, 1150, 1241, 1300, 1352, 1386, 1455, 1713, 1747, 1799, 1827, 2519, 2872, 2931, 2983, 3017, 3099, 3458, 3889, 4161, 4599, 5277, 5314, 5410, 5433, 5455, 5570, 5754, 5877], '(1160)': [657, 1716, 1750, 1830, 4602, 5280, 5757], '9Gnjec': [660, 5283], 'Fonte': [662, 5285], 'J.A.': [663, 5286], 'Atwood': [664, 1003, 1330, 1755, 2961, 3436, 5287, 5359, 5833], 'Martins': [666, 5289], 'R.N.': [667, 5290], 'Front': [668, 5291], 'Biosci.': [669, 5292], '7:': [671, 5294], 'd1016-d1023Crossref': [672, 5295], '(33)': [675, 5298], '10Doraiswamy': [678, 5301], 'P.M.': [679, 5302], 'Finefrock': [680, 5303], 'A.E.': [681, 5304], 'Lancet': [682, 5305], 'Neurol.': [683, 769, 1627, 4667, 5306, 5561, 5822], '2004;': [684, 1092, 1143, 1666, 2542, 4154, 4569, 4784, 4839, 4899, 5307, 5448, 5986, 6318, 6395], '3:': [685, 5308], '431-434Abstract': [686, 5309], '(158)': [694, 5317], 'Supplementing': [697], 'drinking': [700], 'water': [701, 2241, 6365], 'leads': [702, 848, 5723, 5893], 'development': [704], 'rabbit': [709], 'model': [710, 1727], '(11Sparks': [711], 'D.L.': [712], 'Schreurs': [713], 'B.G.': [714], '100:': [723, 832, 1540, 5685, 6089, 6220], '11065-11069Crossref': [724], '(413)': [727], 'High': [730], 'concentrations': [731, 2055, 2155, 2163, 2326, 2436, 2580, 3741, 4523, 5615], '(0.4': [734], 'mm)': [735, 739], '(1': [738], 'have': [740, 3367, 3544, 3571, 4168, 5028, 5735, 6327, 6506], 'reported': [742, 789, 6118], 'senile': [745], 'plaques': [746], 'diseased': [749], 'brain,': [750], 'concentration': [753, 2080, 2096, 2173, 2464, 4236, 5546], 'reaching': [754], '15': [756, 2051, 2093, 2690], 'μm': [757, 2031, 2194, 2209, 2297, 2361, 2663, 2677, 2682, 2761, 2765, 2808, 3191, 3195, 4993], '(12Lovell': [758, 5550], 'M.A.': [759, 1010, 1285, 1335, 2916, 2966, 3441, 5366, 5551], 'Robertson': [760, 5552], 'J.D.': [761, 5553], 'Teesdale': [762, 5554], 'W.J.': [763, 5555], 'Campbell': [764, 5556], 'J.L.': [765, 1500, 5557, 5645, 6049, 6180], 'Markesbery': [766, 5558], 'W.R.': [767, 5559], '1998;': [771, 1293, 2924, 3902, 5563], '158:': [772, 5564], '47-52Abstract': [773, 5565], '(1862)': [781, 5573], 'In': [784, 1547, 1881, 3138, 3355, 6227], 'contrast,': [785], 'decrease': [791, 851, 960, 2782], 'APP23': [795], 'transgenic': [796, 846], 'mice': [797, 847, 891], '(13Bayer': [798], 'T.A.': [799], 'Schafer': [800], 'Simons': [802], 'Kemmling': [804], 'Kamer': [806], 'Tepest': [808], 'Eckert': [810], 'Schussel': [812], 'Eikenberg': [814], 'O.': [815, 1363, 1432, 2994, 3076], 'Sturchler-Pierrat': [816], 'Abramowski': [818], 'Staufenbiel': [820], '14187-14192Crossref': [833], '(313)': [836], 'Moreover,': [839, 3288], 'overexpression': [840], 'human': [842], 'brain': [853, 1700, 5549], '(14Maynard': [855], 'C.J.': [856, 1037, 1110, 1161, 5393, 5466], 'Cappai': [857, 915], 'Volitakis': [859, 1028, 1612, 1767, 4652, 5384, 5807, 5845], 'Cherny': [861, 1602, 4642, 5797], 'R.A.': [862, 1031, 1754, 5387, 5832], 'White': [863], 'A.R.': [864, 898], 'Masters': [867, 913, 1038, 1259, 1624, 1787, 2890, 3396, 4664, 5394, 5819, 5865], 'Bush': [869, 907, 989, 1040, 1288, 1340, 1573, 1590, 1789, 2919, 2971, 3446, 4613, 4630, 5345, 5396, 5768, 5785, 5867], 'Li': [871, 1604, 4644, 5799], 'Q.X.': [872, 1605, 4645, 5800], 'Biol.': [874, 1045, 1070, 1090, 1141, 1234, 1291, 1343, 1377, 1446, 2510, 2541, 2865, 2922, 2974, 3008, 3090, 3449, 4152, 5401, 5426, 5446], 'Chem.': [875, 1046, 1071, 1091, 1142, 1235, 1292, 1344, 1378, 1447, 1665, 1682, 2511, 2866, 2923, 2975, 3009, 3091, 3450, 4153, 4568, 4783, 4800, 4838, 4898, 4915, 5402, 5427, 5447, 5985, 6002, 6317, 6394], '277:': [877], '44670-44676Abstract': [878], '(329)': [886], 'APP': [889], 'knock-out': [890], 'an': [893, 1725, 2414, 2489, 2643, 3964, 5254], 'increase': [894, 4953, 6405], '(15White': [897], 'Reyes': [899], 'Mercer': [901], 'J.F.': [902, 1256, 2887, 3393], 'Camakaris': [903], 'Zheng': [905, 1783, 5861], 'Brain': [917], '1999;': [919, 1112, 1163, 5468], '842:': [920], '439-444Crossref': [921], '(261)': [924], 'complicated;': [935], 'clear': [939], 'whether': [940], 'accumulation': [942], 'cause': [948], 'consequence': [951], 'biological': [956], 'defense': [957], 'response': [958], 'progression': [961], 'bind': [968, 4540], 'high': [973, 3759, 5324, 5545, 5592, 5614], 'affinity': [974, 5325, 5593], '(16Atwood': [975, 5331], 'C.S.': [976, 1004, 1273, 1331, 1756, 2904, 2962, 3437, 5332, 5360, 5834], 'Scarpa': [977, 1278, 2909, 5333], 'R.C.': [978, 1084, 1135, 1279, 2910, 4146, 5334, 5440], 'Huang': [979, 1276, 1569, 1773, 2907, 3431, 4609, 5335, 5764, 5851], 'Moir': [981, 1274, 1332, 1777, 2905, 2963, 3438, 5337, 5855], 'R.D.': [982, 1275, 1333, 1778, 2906, 2964, 3439, 5338, 5856], 'Jones': [983, 1761, 5339, 5839], 'W.D.': [984, 1762, 5340, 5840], 'Fairlie': [985, 5341], 'D.P.': [986, 5342], 'Tanzi': [987, 1067, 1231, 1261, 1286, 1338, 1571, 1622, 1785, 2862, 2892, 2917, 2969, 3398, 3444, 4611, 4662, 5343, 5423, 5766, 5817, 5863], 'R.E.': [988, 1068, 1232, 1262, 1287, 1339, 1572, 1623, 1786, 2863, 2893, 2918, 2970, 3399, 3445, 4612, 4663, 5344, 5424, 5767, 5818, 5864], 'Neurochem.': [992, 1319, 2950, 3422, 5348], '2000;': [993, 1180, 1206, 1580, 4620, 5349, 5485, 5775], '75:': [994, 5350], '1219-1233Crossref': [995, 5351], '(591)': [998, 5354], '17Dong': [1001, 5357], 'Anderson': [1005, 5361], 'V.E.': [1006, 5362], 'Siedlak': [1007, 5363], 'S.L.': [1008, 5364], 'Smith': [1009, 5365], 'Perry': [1011, 5367], 'Carey': [1013, 5369], 'P.R.': [1014, 5370], 'Biochemistry.': [1015, 1111, 1162, 1179, 1205, 5371, 5467, 5484], '42:': [1017, 5373], '2768-2773Crossref': [1018, 5374], '(535)': [1021, 5377], '18Curtain': [1024, 5380], 'C.C.': [1025, 3898, 5381], 'Ali': [1026, 5382], 'Cherney': [1030, 5386], 'Norton': [1032, 5388], 'R.S.': [1033, 5389], 'Barrow': [1036, 1109, 1160, 5392, 5465], 'Barnham': [1042, 1765, 5398, 5843], 'K.J.': [1043, 1766, 5399, 5844], '2001;': [1047, 1379, 1448, 1792, 3010, 3092, 5403, 5870], '276:': [1048, 1380, 1449, 3011, 3093, 5404], '20466-20473Abstract': [1049, 5405], '(604)': [1057, 5413], '19Bush': [1060, 5416], 'Pettingell': [1062, 1226, 1247, 2857, 2878, 3384, 5418], 'W.H.': [1063, 1227, 1248, 2858, 2879, 3385, 5419], 'Paradis': [1064, 1228, 1251, 2859, 2882, 3388, 5420], 'Jr.,': [1065, 1229, 2860, 5421], 'M-d.': [1066, 1230, 2861, 5422], '1994;': [1072, 1236, 1264, 2867, 2895, 3401, 5428, 6107, 6139], '269:': [1073, 1237, 2868, 5429], '12152-12158Abstract': [1074, 1238, 2869, 5430], '20Syme': [1081, 5437], 'C.D.': [1082, 1133, 4144, 5438], 'Nadal': [1083, 1134, 4145, 5439], 'Rigby': [1085, 1136, 4147, 5441], 'S.E.J.': [1086, 1137, 4148, 5442], 'Viles': [1087, 1138, 4149, 5443], 'J.H.': [1088, 1139, 4150, 5444], '279:': [1093, 1144, 4155, 5449], '18169-18177Abstract': [1094, 1145, 4156, 5450], '(414)': [1102, 1153, 4164, 5458], '21Liu': [1105, 1156, 5461], 'S.T.': [1106, 1157, 5462], 'Howlett': [1107, 1158, 5463], '38:': [1113, 1164, 5469], '9373-9378Crossref': [1114, 1165, 5470], '(193)': [1117, 1168, 5473], 'histidine': [1121], 'residues,': [1122], 'especially': [1123, 1422, 1841], 'His-13,': [1124], 'involved': [1126], 'binding': [1128, 3290, 4075, 4140, 4264, 4297, 4448, 5326, 5594], '(20Syme': [1132, 4143], '22Miura': [1171, 5476], 'Suzuki': [1173, 1199, 5478], 'Kohata': [1175, 1201, 5480], 'N.': [1176, 1202, 1373, 1442, 1529, 1576, 3004, 3086, 4616, 5481, 5674, 5771, 6078, 6209], 'Takeuchi': [1177, 1203, 5482], '39:': [1181, 1207, 5486], '7024-7031Crossref': [1182, 1208, 5487], '(423)': [1185, 1211, 5490], 'Scholar),': [1187, 1414, 1690, 3045, 4576, 4846, 4923, 5575, 6010, 6402], 'differ': [1191], 'coordination': [1194, 4552, 6294, 6362], 'His-13': [1196], '(22Miura': [1197], 'trigger': [1217], 'aggregation': [1218, 1873, 1895, 1925, 2818, 2826, 2846, 3131, 3219, 3325, 3381, 3475, 3500, 3558, 4360, 5630], 'precipitation': [1220, 5632], '(19Bush': [1224, 2855], '23Bush': [1245, 2876], 'Vonsattel': [1253, 1336, 2884, 2967, 3390, 3442], 'J.P.': [1254, 1337, 2885, 2968, 3391, 3443], 'Gusella': [1255, 2886, 3392], '265:': [1265, 2896, 3402], '1464-1467Crossref': [1266, 2897, 3403], '(1435)': [1269, 2900, 3406], '24Atwood': [1272, 2903], 'Bacarra': [1280, 2911], 'N.M.': [1281, 2912], 'Romano': [1282, 2913], 'D.M.': [1283, 2914], 'Hartshorn': [1284, 1334, 2915, 2965, 3440], '273:': [1294, 2925], '12817-12826Abstract': [1295, 2926], '(952)': [1303, 2934], '25Esler': [1306, 2937, 3409], 'W.P.': [1307, 2938, 3410], 'Stimson': [1308, 2939, 3411], 'E.R.': [1309, 2940, 3412], 'Jennings': [1310, 2941, 3413], 'J.M.': [1311, 2942, 3414], 'Ghilardi': [1312, 2943, 3415], 'J.R.': [1313, 2944, 3416], 'Mantyh': [1314, 2945, 3417], 'P.W.': [1315, 2946, 3418], 'Maggio': [1316, 2947, 3419], 'J.E.': [1317, 2948, 3420], '1996;': [1320, 2951, 3423], '66:': [1321, 2952, 3424], '723-732Crossref': [1322, 2953, 3425], '(126)': [1325, 2956, 3428], '26Huang': [1328, 2959], '272:': [1346, 2977, 3452], '26464-26470Abstract': [1347, 2978, 3453], '(311)': [1355, 2986, 3461], '27Yoshiike': [1358, 2989], 'Y.': [1359, 1428, 1577, 1772, 2508, 2538, 2990, 3072, 4617, 5772, 5850], 'Tanemura': [1360, 1429, 2991, 3073], 'Murayama': [1362, 1366, 1431, 1435, 2993, 2997, 3075, 3079], 'Akagi': [1364, 1433, 2995, 3077], 'Sato': [1368, 1437, 1520, 1530, 2999, 3081, 5665, 5675, 6069, 6079, 6200, 6210], 'Sun': [1370, 1439, 3001, 3083], 'Tanaka': [1372, 1441, 3003, 3085], 'Takashima': [1374, 1443, 3005, 3087], '32293-32299Abstract': [1381, 1450, 3012, 3094], '(236)': [1389, 1458, 3020, 3102], '28Klug': [1392, 1461, 3023, 3105], 'G.M.': [1393, 1462, 3024, 3106], 'Losic': [1394, 1463, 3025, 3107], 'Subasinghe': [1396, 1465, 3027, 3109], 'S.S.': [1397, 1466, 3028, 3110], 'Aguilar': [1398, 1467, 3029, 3111], 'M.I.': [1399, 1468, 3030, 3112], 'Martin': [1400, 1469, 3031, 3113], 'L.L.': [1401, 1470, 3032, 3114], 'Small': [1402, 1471, 3033, 3115], 'D.H.': [1403, 1472, 3034, 3116], 'Eur.': [1404, 1473, 3035, 3117], '270:': [1408, 1477, 3039, 3121], '4282-4293Crossref': [1409, 1478, 3040, 3122], '(102)': [1412, 1481, 3043, 3125], 'distinct': [1417, 5174, 5932, 6487], 'from': [1418, 1973, 1993, 2003, 2013, 2148], 'fibrils,': [1421, 3778, 6164], 'β-sheet': [1425, 3271, 3951, 3968, 3984, 4013, 4042, 6123], 'content': [1426], '(27Yoshiike': [1427, 3071], 'Toxicity': [1484, 6115], 'granular': [1486, 6151], 'target': [1490], 'extensive': [1493], 'studies': [1494, 2854, 3304], '(29Kayed': [1495, 5640, 6044, 6175], 'Head': [1497, 5642, 6046, 6177], 'E.': [1498, 5643, 6047, 6178], 'Thompson': [1499, 5644, 6048, 6179], 'McIntire': [1501, 5646, 6050, 6181], 'T.M.': [1502, 5647, 6051, 6182], 'Milton': [1503, 5648, 6052, 6183], 'S.C.': [1504, 5649, 6053, 6184], 'Cotman': [1505, 5650, 6054, 6185], 'Glabe': [1507, 5652, 6056, 6187], 'C.G.': [1508, 5653, 6057, 6188], '300:': [1511, 5656, 6060, 6191], '486-489Crossref': [1512, 5657, 6061, 6192], '(3519)': [1515, 5660, 6064, 6195], '30Hoshi': [1518, 5663, 6067, 6198], 'Matsumoto': [1522, 5667, 6071, 6202], 'Noguchi': [1524, 5669, 6073, 6204], 'Yasutake': [1526, 5671, 6075, 6206], 'Yoshida': [1528, 5673, 6077, 6208], '6370-6375Crossref': [1541, 5686, 6090, 6221], '(451)': [1544, 5689, 6093, 6224], 'this': [1548, 1929, 3309, 3356, 3562, 6228], 'respect,': [1549, 6229], '"metal-protein': [1553], 'attenuation': [1554], 'compounds"': [1555], 'proposed': [1557, 4579], 'strategy': [1561], 'treating': [1563], '(31Cuajungco': [1565], 'M.P.': [1566, 4606, 5761], 'Faget': [1567, 4607, 5762], 'K.Y.': [1568, 4608, 5763], 'Ann.': [1575, 4615, 5770], '920:': [1581, 4621, 5776], '292-304Crossref': [1582, 4622, 5777], '(185)': [1585, 4625, 5780], '32Ritchie': [1588, 4628, 5783], 'Mackinnon': [1592, 4632, 5787], 'Macfarlane': [1594, 4634, 5789], 'Mastwyk': [1596, 4636, 5791], 'MacGregor': [1598, 4638, 5793], 'Kiers': [1600, 4640, 5795], 'Tammer': [1606, 4646, 5801], 'Carrington': [1608, 4648, 5803], 'Mavros': [1610, 4650, 5805], 'Xilinas': [1614, 1757, 4654, 5809, 5835], 'Ames': [1616, 4656, 5811], 'Arch.': [1626, 4666, 5821], '60:': [1629, 4669, 5824], '1685-1691Crossref': [1630, 4670, 5825], '(915)': [1633, 4673, 5828], 'antibiotic,': [1637], '(CQ),': [1639], 'also': [1642, 3712, 3970, 4068, 4367, 5542, 6519], 'known': [1643, 1998, 4135, 4764], 'transition': [1647, 4765, 5261, 6538], 'chelator': [1650], '(33Di': [1651, 4554, 4769, 4824, 4884, 5971, 6303, 6380], 'Vaira': [1652, 4555, 4770, 4825, 4885, 5972, 6304, 6381], 'Bazzicalupi': [1654, 4557, 4772, 4827, 4887, 5974, 6306, 6383], 'Orioli': [1656, 4559, 4774, 4829, 4889, 5976, 6308, 6385], 'Messori': [1658, 4561, 4776, 4831, 4891, 5978, 6310, 6387], 'Bruni': [1660, 4563, 4778, 4833, 4893, 5980, 6312, 6389], 'Zatta': [1662, 4565, 4780, 4835, 4895, 5982, 6314, 6391], 'Inorg.': [1664, 4567, 4782, 4837, 4897, 5984, 6316, 6393], '43:': [1667, 4570, 4785, 4840, 4900, 5987, 6319, 6396], '3795-3797Crossref': [1668, 4571, 4786, 4841, 4901, 5988, 6320, 6397], '(268)': [1671, 4574, 4789, 4844, 4904, 5991, 6323, 6400], '34Lane': [1674, 4792, 4907, 5994], 'T.J.': [1675, 4793, 4908, 5995], 'Sam': [1676, 4794, 4909, 5996], 'C.S.C.A.': [1677, 4795, 4910, 5997], 'Kandathil': [1678, 4796, 4911, 5998], 'A.J.': [1679, 4797, 4912, 5999], 'Am.': [1681, 4799, 4914, 6001], 'Soc.': [1683, 4801, 4916, 6003], '1960;': [1684, 4802, 4917, 6004], '4462-4465Crossref': [1686, 4804, 4919, 6006], '(16)': [1688, 4806, 4921, 6008], 'found': [1693, 5543, 6158], 'dissolve': [1695], 'tissue': [1701], 'Scholar)': [1718, 2404, 3463, 4808, 5319, 6325], 'yield': [1721], 'promising': [1722], 'animal': [1726], 'decreasing': [1731], 'number': [1733], '36Cherny': [1753, 5831], 'M.E.': [1758, 5836], 'Gray': [1759, 5837], 'D.N.': [1760, 5838], 'McLean': [1763, 5841], 'C.A.': [1764, 5842], 'Fraser': [1769, 5847], 'F.W.': [1770, 5848], 'Kim': [1771, 5849], 'Goldstein': [1775, 5853], 'L.E.': [1776, 5854], 'Lim': [1779, 5857], 'J.T.': [1780, 5858], 'Neuron.': [1791, 5869], '30:': [1793, 5871], '665-676Abstract': [1794, 5872], '(1342)': [1802, 5880], 'CQ': [1805, 1995, 2021, 2067, 2184, 2683, 2739, 2809, 4531, 4685, 4704, 4720, 4810, 4862, 4945, 5008, 5022, 5047, 5096, 5110, 5133, 5139, 5158, 5177, 5211, 5242, 5698, 5734, 5892, 5906, 5935, 5956, 6033, 6230, 6379, 6485, 6504], 'focus': [1809], 'attention': [1811], 'on': [1836, 1871, 1893, 1942, 2025, 2224, 2473, 2488, 2743, 2816, 3135, 3259, 3266, 3307, 3372, 3580, 4019, 4176, 4383, 4532, 4686, 4695, 4979, 5015, 5113, 5147, 5178, 5243, 5583, 5704, 5936, 6169, 6489], 'conjunction': [1843], 'understood': [1851, 3547, 5537], 'so': [1852, 3548], 'far.': [1853, 3549], 'Therefore,': [1854, 2152, 3493], 'important': [1857, 3360, 5497, 5694], 'obtain': [1859], 'interactions': [1864, 4270], 'impact': [1870, 3485], 'formation': [1877, 3239, 3272, 4043, 6015, 6127], 'peptides.': [1880], 'present': [1883], 'study,': [1884], 'we': [1885, 3141, 3316, 3834, 5125, 5944], 'investigated': [1886, 3572, 4072, 4169], 'some': [1890, 6328], 'fibrillogenic': [1897, 1914, 3513, 3535, 4499, 5529, 5585, 6019], 'propensities': [1898, 3514, 3536], 'render': [1911], 'less': [1913, 3351, 3502, 3607, 3681, 4876, 4962, 5528, 6018], 'non-fibrillogenic': [1916, 4502, 6461], 'under': [1917, 4234, 4343, 5619, 6238], 'conditions': [1918, 3343, 5725, 6241], 'no': [1921, 3353, 3701, 5213], 'significant': [1922, 2790, 3167, 3218, 4439, 5013, 5214, 5581], 'occurs.': [1926], 'system': [1930, 2146, 2479, 3563], 'examine': [1932], 'effects': [1934, 1953, 3261, 3574, 4018, 4683, 5175, 5703, 5933, 6488, 6509], 'EDTA': [1939, 2431, 4722, 5722], 'revealed': [1950, 3921, 5212], 'explaining': [1956], 'underlying': [1958], 'Materials—Human': [1969], 'was': [1971, 2001, 2011, 2045, 2069, 2075, 2100, 2116, 2222, 2235, 2248, 2254, 2267, 2287, 2411, 2453, 2471, 2485, 2706, 2788, 3647, 3700, 4230, 4300, 4361, 4486, 5001, 5535], 'purchased': [1972, 1988, 2012], 'Peptide': [1975, 2095], 'Institute,': [1976], 'Inc.': [1977, 2016], '(Osaka,': [1978], 'Japan).': [1979, 2018], 'CuCl2': [1980], 'dihydrate,': [1981], 'anhydrous': [1982, 1985], 'ZnCl2,': [1983], 'FeCl3': [1986], 'purest': [1991], 'forms': [1992, 4811], 'Aldrich.': [1994], '(5-chloro-7-iodo-8-hydroxyquinoline,': [1996], 'commonly': [1997], 'clioquinol)': [2000], 'procured': [2002], 'Calbiochem.': [2004], '"Protein': [2005], 'assay': [2006, 2110], 'Coomassie': [2007, 2111], 'Brilliant': [2008, 2112], 'Blue': [2009, 2113], 'solution"': [2010], 'Nacalai': [2014], 'Tesque': [2015], '(Kyoto,': [2017], 'Effects': [2019, 2737, 4529], 'Buffer': [2023, 2741, 4033], 'Conditions': [2024, 2742], 'Metal': [2026, 2744, 4527], 'Ion-induced': [2027, 2745], 'Aggregation': [2028, 2746], 'Aβ1–40—50': [2030], 'indicated': [2035, 2043, 2444, 3059], 'buffers': [2036], 'presence': [2039, 2323, 2577, 2674, 3188, 3821, 3937, 3974, 3991, 5033, 5061, 5088, 5136, 5206], 'absence': [2041, 2321, 2575, 2670, 5204], 'substances': [2044], 'incubated': [2046, 2213, 2229, 2331, 2572, 2685, 3789], 'at': [2047, 2088, 2332, 2350, 2375, 2442, 2584, 2613, 2686, 2695, 2699, 2708, 2714, 2720, 2791, 2795, 3593, 3677, 3740, 3754, 4094, 4103, 4126, 4432, 5544], '37': [2048, 2333, 2585, 2614, 2687, 4433], '°C': [2049, 2334, 2586, 2615, 2688, 4434], 'min.': [2052, 2094, 2216, 2232], 'final': [2054, 2079, 2172, 2463], 'samples': [2062, 2085, 2347, 2457, 2563, 2593, 3770, 3781], '50': [2064, 2193, 2208, 2296, 2302, 2365, 2676, 2760, 2764, 3190, 3194], 'μm.': [2065, 2083], 'Stock': [2066], 'solution': [2068, 2114], 'prepared': [2070], 'methanol,': [2072], 'added': [2076, 2162, 2355, 2441, 2454], '100': [2082, 2204, 2310, 2681, 2752, 2807], 'centrifuged': [2087], '13,000': [2089], '×': [2090, 2701, 4305], 'g': [2091], 'supernatant': [2099], 'determined': [2101], 'Bradford': [2104], 'method': [2105], 'using': [2106, 2256, 2420, 2609, 2642, 2731], 'commercial': [2108], 'represented': [2117], 'percentage': [2120, 2770, 2785], 'recovery': [2122, 2772, 2787, 2832], 'relative': [2123, 3512, 3534], 'control': [2126, 3667, 5080], 'without': [2127], 'CQ.': [2131, 3051], 'did': [2133, 2185, 2810, 3142, 3732, 3986, 4316, 4435, 4706, 5126], 'measure': [2135], 'trace': [2137], 'contamination': [2138], 'our': [2144, 2177, 3208, 3256, 3495, 4400, 5235, 5515, 6258], 'buffer': [2145, 2316, 2459, 2559, 2599, 2666, 2750, 3136, 3139, 3182, 3223, 3233, 3286, 3295, 3327, 3482, 3505, 3560, 3588, 3810, 3914, 4058, 4257, 4341, 4375, 5621, 6240], 'preparations.': [2151], 'mentioned': [2154], 'represent': [2160], 'Unless': [2168], 'otherwise': [2169], 'mentioned,': [2170], 'methanol': [2175], 'experiment': [2178, 4331], 'addition': [2182, 4098, 4193, 4309, 4718, 4741, 5020, 5094, 5890], 'exceed': [2187], '2%.': [2188], 'Atomic': [2189, 2250], 'Force': [2190], 'Microscopy—Samples': [2191], '20': [2197], 'mm': [2198, 2205, 2303, 2311, 2366, 2753, 3824], 'HEPES': [2199, 2749, 2840], 'buffer,': [2200, 2306, 2368, 2841], 'pH': [2201, 2307, 2369, 2792, 2796, 2800], '7.4,': [2202, 2308, 2797], 'containing': [2203, 2309, 2751], 'NaCl': [2206, 2312, 2754], '5': [2215, 2336, 2360, 2466, 3706, 6254], 'An': [2217], 'aliquot': [2218], 'sample': [2221, 2234, 2470, 4725, 5025, 5085], 'placed': [2223, 2472], 'mica': [2226, 2246], 'surface': [2227, 2247], '1': [2231, 2357], 'Excess': [2233], 'drained': [2236], 'washed': [2238], 'quickly': [2239], 'remove': [2243], 'salts.': [2244], 'air-dried.': [2249], 'force': [2251, 2259, 3054], 'microscopy': [2252, 3055], 'imaging': [2253], 'performed': [2255, 2641], 'dynamic': [2258], 'microscope,': [2260], 'SPI3700-SPA300,': [2261], 'Seiko': [2262, 2272], 'Instruments.': [2263], 'scanning': [2265], 'tip': [2266], 'silicon': [2269], 'microcantilever': [2270], '(SI-DF20,': [2271], 'Instruments,': [2273], 'spring': [2274], 'constant': [2275, 4293], '=': [2276, 2281], '13': [2277], 'newton/m,': [2278], 'resonance': [2279], 'frequency': [2280], '135': [2282], 'kHz).': [2283], 'scan': [2285], 'rate': [2286], '0.5': [2288], 'Hz.': [2289], 'Amyloid': [2290], 'Fibril': [2291, 3530, 3797, 4394, 4534], 'Growth': [2292, 3531], 'Aβ1–40—Samples': [2294], '(∼0.22': [2298], 'mg/ml)': [2299], 'sodium': [2304], 'phosphate': [2305, 3242, 4061], '(referred': [2313], 'A': [2317, 2460, 2560, 2667, 2777, 2835, 3183, 3234, 3296, 3328, 3506, 3589, 3811, 3915, 4258, 4376], 'henceforth)': [2318], 'required': [2325, 2435, 2579], 'μg/ml': [2337], 'sonicated': [2338], '(fibril': [2340], 'seed).': [2341], 'Aliquots': [2342], '(5': [2343, 2570], 'μl)': [2344], 'withdrawn': [2349], 'different': [2351, 3365, 4551], 'time': [2352, 2445, 3619, 3654, 6452], 'points': [2353], 'ml': [2358], 'T': [2363], 'glycine-NaOH': [2367], '8.5': [2370], '(ThT': [2371], 'solution).': [2372], 'Fluorescence': [2373, 2450], 'intensity': [2374, 4185], '485': [2376], 'nm,': [2377], 'proportional': [2380], 'extent': [2383, 3664], 'fibril-bound': [2385], 'ThT': [2386, 4024, 4447, 5232], '(37Naiki': [2387], 'Higuchi': [2389], 'Hosokawa': [2391], 'Takeda': [2393], 'Anal.': [2395], '1989;': [2397], '177:': [2398], '244-249Crossref': [2399], '(1039)': [2402], 'thus': [2406, 4114, 4452], 'growth,': [2410, 4484, 5018, 5104, 5916], 'measured': [2412], 'excitation': [2415], 'wavelength': [2416], '445': [2418], 'nm': [2419, 3958], 'Hitachi': [2422], 'F-4500': [2423], 'spectrophotometer.': [2425], 'To': [2426], 'test': [2427], 'points.': [2446], 'Total': [2447], 'Internal': [2448], 'Reflection': [2449], 'Microscopy': [2451], '(TIRFM)—ThT': [2452], 'μm,': [2467], 'glass': [2475], 'slide.': [2476], 'TIRFM': [2478, 3768], 'observe': [2481, 3144, 5128], 'ThT-bound': [2482, 3772], 'developed': [2486], 'based': [2487], 'inverted': [2490], 'microscope': [2491], '(IX70;': [2492], 'Olympus,': [2493], 'Tokyo,': [2494], 'Japan)': [2495], 'described': [2497], 'earlier': [2498, 2853, 3069, 3368], '(38Ban': [2499], 'Hamada': [2501, 2531], 'Hasegawa': [2503, 2533], 'Naiki': [2505, 2535], 'Goto': [2507, 2537], '278:': [2513], '16462-16465Abstract': [2514], '(309)': [2522], '39Ban': [2525], 'Hoshino': [2527], 'Takahashi': [2529], 'Mol.': [2540], '344:': [2543], '757-767Crossref': [2544], '(211)': [2547], 'Circular': [2550], 'Dichroism—Samples': [2551], '0.22': [2553], 'mg/ml': [2554], 'alone': [2557, 3184, 3812, 4705], 'seeds': [2569, 3839, 3940], 'μg/ml)': [2571], '80': [2588, 3942], 'min': [2589, 2691, 3943], 'prepared.': [2591], 'diluted': [2595], '1:1': [2596], '(v/v)': [2597], 'A,': [2600, 3140, 3561, 4059, 4342], 'far': [2603, 3924], 'UV': [2604], 'CD': [2605, 3948], 'spectra': [2606], 'recorded': [2608], 'Jasco-600': [2611], 'spectropolarimeter': [2612], 'thermo-stated': [2617], 'cell': [2618], 'holder': [2619], '0.1-cm': [2622], 'path': [2623], 'length': [2624], 'quartz': [2625], 'cuvette.': [2626], 'data': [2628, 2728, 4288], 'shown': [2629, 5624], 'mean': [2632], 'residue': [2633, 4088, 4093, 4123, 4280], 'ellipticity.': [2634], 'Sedimentation': [2635, 5195], 'Velocity': [2636], 'Measurements—Sedimentation': [2637], 'velocity': [2638, 3154, 5196], 'measurements': [2639, 3155], 'Optima': [2644], 'XL-I': [2645], 'analytical': [2646], 'ultracentrifuge': [2647], '(Beckman': [2648], 'Coulter)': [2649], 'An-60': [2651], 'rotor': [2652], 'two-channel': [2654], 'charcoal-filled': [2655], 'Epon': [2656], 'cells.': [2657], 'Samples': [2658], '(0.3': [2659], 'ml)': [2660], '30': [2662], 'followed': [2692], 'centrifugation': [2694], 'same': [2697, 4547], 'temperature': [2698], '224,000': [2700], 'g.': [2702], 'boundary': [2705, 2718], 'scanned': [2707], '12-min': [2709], 'intervals': [2710, 2723], 'absorbance': [2713], '225': [2715], 'nm.': [2716, 4128], 'curves': [2719, 3998], 'every': [2721], '24-min': [2722], 'shown.': [2725], 'sedimentation': [2727, 3153, 3171, 3177], 'analyzed': [2730], 'software': [2733], 'Origin': [2734], '4.1': [2735], '(OriginLab).': [2736], 'Aβ1–40—In': [2748], '(pH': [2755, 3590], '6.6': [2756, 2793], '7.4),': [2758], 'both': [2759, 4541, 4814], 'largely': [2767], 'decreased': [2768, 4190], '(Fig.': [2775, 2833, 3057, 3150, 3173, 3601, 3725, 3749, 3795, 3813, 3826, 3842, 3927, 3959, 3977, 3996, 4026, 4199, 4243, 4289, 4326, 4389, 4504, 4715, 4737, 4757, 5005, 5119, 5150, 5216, 6242], '1,': [2776, 2834, 5627], 'B).': [2779, 2837], 'Cu2+-induced': [2781], 'more': [2789, 3639, 6160], 'than': [2794, 3608, 3640, 3682, 6162], 'indicating': [2798, 5105], 'dependence': [2801], 'effects.': [2805], 'itself': [2812, 5009], 'exhibit': [2813, 3166, 3873, 5012, 5323, 5579, 5910], 'notable': [2814], 'suppressed': [2822, 3049, 4754], 'increasing': [2830, 5255], 'induce': [2845, 3556], 'agreement': [2850], 'can': [3047, 4539, 6231, 6249, 6404, 6472], 'atomic': [3053], 'images': [3056], '1D)': [3058], 'amorphous': [3065], 'nature,': [3067, 5533], 'supporting': [3068], 'reports': [3070], 'Importantly,': [3128], 'depended': [3134], 'conditions.': [3137], 'loss': [3147], '1C).': [3151], 'Furthermore,': [3152], 'showed': [3156], 'iontreated': [3160], 'untreated': [3162], 'do': [3164, 3215, 5223], 'change': [3168], 'property': [3172], '2).': [3174, 3962], 'apparent': [3176], 'coefficients': [3178], 'calculated': [3198, 4301], '0.96,': [3201], '0.86,': [3202], '1.05': [3204], 's,': [3205], 'respectively.': [3206], 'result': [3209, 4437], 'shows': [3210, 4044, 4332, 5887], 'promote': [3217, 5225], 'One': [3225], 'possible': [3226, 4487, 4931, 5962], 'reason': [3227], 'observation': [3230, 3496, 4401], 'made': [3231, 3369], 'complexes': [3243, 4812, 4868, 5222, 5967, 6278, 6298], 'prevents': [3248, 3859, 4009, 4481], 'interaction': [3250], 'peptide.': [3254, 4182], 'following': [3257], 'interacts': [3280, 4368], 'supported': [3299], 'quenching': [3303, 4203, 4214, 4248, 4287, 4320], 'presented': [3305], 'later': [3306], 'study.': [3310], 'taking': [3312], 'together': [3313, 5909], 'evidences,': [3315], 'presume': [3317, 4364], 'lack': [3321, 3334, 4852, 5042], 'binding.': [3338], 'Rather,': [3339], 'represents': [3341, 4116], 'ion-bound': [3348], 'exhibits': [3350, 4975, 5699, 6486], 'aggregation.': [3354], 'context,': [3357], 'note': [3362], 'two': [3364, 4100, 5496], 'laboratories': [3366], 'contradictory': [3370], 'observations': [3371], 'susceptibility': [3374, 3467], 'Zn2+-induced': [3380, 3474, 6493], '(23Bush': [3382], 'et': [3432], 'al.': [3433], '(26Huang': [3434], 'clarified': [3464], 'sensitive': [3477], '"complex': [3479], 'factors': [3480, 4514], 'milieu': [3483], 'upon': [3486, 4124, 4139, 4191], "peptide's": [3488], 'conformation': [3489, 3919], 'polymerization': [3491], 'state."': [3492], 'interestingly,': [3494], 'pronounced': [3503], 'useful': [3508, 3565, 6531, 6585], 'understand': [3510], 'metal-free': [3517], '(apo)': [3518], 'metal-bound': [3520], '(holo)': [3521], 'Effect': [3523], 'Fe3+on': [3528], 'Aβ1–40—The': [3533], 'apoand': [3539], 'holo-forms': [3540, 4503, 5521], 'Since': [3550, 4474, 4759, 4867, 5007], 'does': [3554, 4083, 4863, 5010, 5577, 5605], 'detectable': [3557], 'address': [3567], 'issue.': [3569], '7.4).': [3591], 'Even': [3592], 'substoichiometric': [3594], 'concentrations,': [3595], 'retarded': [3597], '3A).': [3602], 'At': [3603, 3635, 3687, 4991], 'molar': [3605, 3637, 3679, 3689, 3756], 'ratio': [3606, 3638, 3680, 3690, 3757], '0.4': [3609], 'increased': [3617], 'lag': [3620], 'onset': [3623], '(despite': [3628], 'seed': [3632, 3788], 'nucleation).': [3634], 'equal': [3642], '0.4,': [3644], 'significantly': [3650, 4232, 4714, 6438], 'during': [3651], 'period.': [3655], 'occurred': [3660, 3801, 3971], 'slowly': [3661], '(without': [3668], 'ion)': [3671], '2': [3673], 'days': [3674, 3707], 'incubation': [3676, 4420], '0.6': [3683], '(data': [3684, 3708, 3762, 3848, 4449], 'shown).': [3686, 3710, 3764], '1.0,': [3692], 'prevented': [3694, 4406, 5002], 'completely;': [3698], 'there': [3699], 'even': [3704, 3818], 'after': [3705], 'exhibited': [3713, 3916], 'similar': [3715, 4820], 'preventing': [3718], '3B).': [3726], 'On': [3727, 3830, 5121, 5610, 6147], 'other': [3729, 3832, 5123, 5226, 5612, 6149], 'hand,': [3730, 3833, 5124, 5613, 6150], 'prevent': [3734, 6439], 'comparable': [3742], 'those': [3744, 4881], '3B)': [3750, 4390], '4.0': [3761], 'examined': [3766], 'seed,': [3774], '3C).': [3796], 'order': [3804], 'few': [3807], 'micrometers': [3808], '3C,': [3814, 3827, 3843], 'image': [3815, 3828, 3844], '2)': [3816], '0.2': [3823], '3).': [3829, 3980, 4027], 'see': [3836], 'only': [3837, 5003, 6512], 'Cu2+-treated': [3841, 4475, 4727], '4)': [3845], 'Zn2+-treated': [3847], 'shown)': [3850], 'samples.': [3851], 'Prevent': [3868], 'β-Sheet': [3870], 'Formation—Amyloid': [3871], 'characteristic': [3874, 3946], 'ordered': [3876], 'cross-β-sheet': [3877], 'structure': [3878, 3952, 3969, 3985], '(40Wetzel': [3879], 'Structure.': [3881], '10:': [3883], '1031-1036Abstract': [3884], '(127)': [3892], '41Sunde': [3895], 'Blake': [3897], 'Q.': [3899], 'Rev.': [3900], '31:': [3903], '1-39Crossref': [3904], '(408)': [3907], 'freshly': [3911], 'dissolved': [3912], 'random': [3917], 'coil': [3918], 'UV-CD': [3925], 'spectrum': [3926, 3949], '4,': [3928, 3960, 3978, 3997], 'curve': [3929, 3961, 3979], '1).': [3930], 'Incubation': [3931], 'generated': [3944], 'far-UV': [3947], 'minimum': [3955], 'around': [3956], '218': [3957], 'Such': [3963, 6353], 'association-induced': [3965, 4041], 'generation': [3966, 4011, 6124], 'induction': [3982], 'occur': [3988], '4': [3999], '5).': [4001], 'structure,': [4014], 'consistent': [4015], 'monitored': [4022], 'Copper': [4028], 'Binding': [4029], 'A—Prevention': [4034], 'interact': [4052, 6413], 'where': [4060], 'complexation': [4062, 6500], 'favored.': [4069], 'spectroscopy.': [4078], 'sequence': [4080], 'contain': [4085], 'any': [4086, 5029], 'tryptophan': [4087], 'single': [4091], 'tyrosine': [4092, 4122, 4228, 4279], 'position': [4095], '10': [4096, 4992], 'phenylalanine': [4101], 'residues': [4102], 'positions': [4104], '19': [4105], '20.': [4107], 'intrinsic': [4109, 4130, 4178, 4251], 'predominantly': [4115], 'sole': [4121], 'exciting': [4125], '280': [4127], 'Aβ1–28': [4133], 'quenched': [4138, 4233], 'progressively': [4189], 'paramagnetic': [4196, 4220], 'ion,': [4197, 4221, 4313], '5A).': [4200], 'This': [4201], 'general': [4212], 'collisional': [4213], 'N-acetyl': [4227], 'amide': [4229], 'range': [4237], '5B).': [4244], 'specific': [4247, 4263], 'leading': [4267, 6011], 'proximal': [4269], 'quencher': [4273], '(Cu2+)': [4274], 'fluorophore': [4277], '(the': [4278], 'peptide).': [4283], 'Using': [4284], '5C),': [4290], 'dissociation': [4292, 4440], '(Kd)': [4294], 'copper': [4296], '∼8': [4304], '106': [4306], 'm.': [4307], 'diamagnetic': [4312], 'however,': [4315], 'lead': [4318, 4939, 5628, 6341], '5C).': [4327], 'binds': [4335, 4371], 'condition': [4345], 'prevention': [4351, 4469], 'observed.': [4362], 'since': [4377], 'behaved': [4379], 'similarly': [4380], 'Switching': [4391], 'On/Off': [4392], 'Growth—One': [4395], 'reasons': [4398, 4464], 'destabilize': [4416], 'fibrils.': [4418], 'judged': [4445], 'shown),': [4451], 'ruling': [4453], 'out': [4454, 5948], 'possibility': [4456, 4926, 4969, 5039, 5053, 5166, 5950], 'instability': [4459], 'one': [4461, 4510], 'metal-induced': [4468, 6234], 'switch': [4489], '6).': [4505, 6256], 'determining': [4515], 'environmental': [4522], 'Ion-dependent': [4528], 'Growth—The': [4535], 'antibiotic': [4536], 'stoichiometry': [4548, 4821], 'geometry': [4553, 6295], 'serve': [4581], '31Cuajungco': [4605, 5760], 'It': [4676, 5589], 'would': [4677, 5070], 'pertinent': [4679], 'study': [4681, 5494, 5516, 5886, 6447, 6528], 'suppression': [4699, 6494], 'affect': [4708, 6280], '7A).': [4716], 'led': [4729, 4747, 5097], 'Cu2+-suppresed': [4734], '7B).': [4738], 'Interestingly,': [4739], 'EDTA,': [4743], '7C).': [4758], '8-hydroxyquinoline': [4760, 4870, 5969], 'derivatives': [4761, 4871, 5970], '2:1': [4823], 'unlikely': [4849], 'because': [4861], 'chelate': [4865], 'relatively': [4875], 'compared': [4879], 'second': [4925, 5052, 5693], 'lesser': [4932, 5963], 'stability': [4933, 5964], 'Zn2+-CQ': [4936, 4973, 5185, 5925], 'may': [4938, 4951, 5599, 5637, 6326, 6340, 6505], 'shuttling': [4941, 5952], 'transiently': [4952], 'population': [4955], 'holo-form': [4957, 6456], 'competent': [4963], 'third': [4968, 5165], 'novel': [4976], 'retardation': [4977, 5100, 5912, 5919], 'We,': [4982], 'therefore,': [4983], 'attempted': [4984], 'verify': [4986], 'possibilities': [4988], 'follows.': [4990], 'partially': [5004], '8A).': [5006, 5120], 'should': [5026, 6025, 6529], 'if': [5036], 'first': [5038, 6451], 'chelation': [5045], 'valid.': [5049], 'If': [5050], 'primary': [5056], 'reason,': [5057], 'then': [5058], 'profile': [5069], 'expected': [5072], 'alone.': [5091], 'Surprisingly,': [5092], 'Cu2+;': [5138], 'completely': [5140, 5946], 'eliminates': [5141], 'suppressive': [5143], '8B).': [5151], 'From': [5152], 'appears': [5162, 5590], 'responsible': [5168, 5928], 'phenomenon': [5172], 'Cu2+-': [5180, 5938, 6491], 'growth;': [5184], 'Cu2+-CQ': [5189], 'experiments': [5197, 5732], 'changes': [5215], '9),': [5217], 'suggesting': [5218, 5917], 'ion-CQ': [5221], 'non-fibrillar': [5227], 'detected': [5230], 'fluorescence.': [5233], 'demonstrate': [5237], 'process': [5247], 'ion-dependent.': [5250], 'There': [5251], 'Our': [5493, 5883, 6446, 6527], 'provides': [5495], 'findings': [5498], 'AD.': [5513, 6035, 6565], 'Firstly,': [5514], 'demonstrates': [5517, 6448], 'soluble': [5520, 6455], '(Cu2+-': [5522], 'Zn2+-bound)': [5524], 'earlier.': [5538], 'propensity': [5586], 'actually': [5600], 'beneficial': [5602, 6508], 'favor': [5607], 'formation.': [5609], 'certain': [5620, 6239], 'conditions,': [5622], 'Fig.': [5626], 'toxic': [5639, 6040, 6161], 'finding': [5695], 'unique': [5700], 'ion-dependent': [5702], 'Chelation': [5711], 'favorable': [5726, 6357], 'Animal': [5731], 'provided': [5736], 'encouraging': [5737], 'vitro': [5885], 'cannot': [5945], 'rule': [5947], 'transient': [6014], 'holo-form.': [6020], 'Both': [6021], 'mechanisms': [6024], 'prove': [6026, 6530], 'advantageous': [6027], 'Monomeric': [6036], 'cells': [6043], '35Lorenzo': [6096], 'B.A.': [6099, 6131], '91:': [6108, 6140], '12243-12247Crossref': [6109, 6141], '(1313)': [6112, 6144], 'associated': [6121], '(35Lorenzo': [6128], 'aggregates,': [6152], 'formed': [6153], 'before': [6154], 'toxicity': [6167], 'depends': [6168], 'size': [6171], 'disaggregate': [6232], '1)': [6243], 'and,': [6244], 'retard': [6250], '(Figs.': [6253], 'suggest': [6260], 'Zn2+-complex,': [6263], 'Cu2+-complex': [6267], 'how': [6276], 'distinctly': [6279], 'propagation': [6282, 6544], 'clear.': [6285], 'consider': [6287], 'difference': [6290], 'play.': [6331], 'planar': [6333], 'nature': [6334, 6463], 'stacking': [6343, 6354], 'aromatic': [6346], 'ring,': [6347], 'promoting': [6348], 'self-association': [6349], 'complex.': [6352], 'fifth': [6361], 'involving': [6363], 'puckered': [6372], 'configuration': [6373], 'availability': [6407], 'interfere': [6415], 'probably': [6425], 'hydrophobic': [6427], 'interactions.': [6428], 'conclude': [6430], 'Particularly,': [6499], 'disaggregating': [6513], 'ioninduced': [6516], 'retarding': [6521], 'provide': [6551], 'concerning': [6553], 'Raman': [6567], 'thanks': [6568], 'Dr.': [6569, 6573], 'Ramakrishna': [6571], 'Ch.': [6574], 'Mohan': [6575], 'Rao,': [6576], 'Centre': [6577], 'Cellular': [6579], 'Molecular': [6581], 'Biology,': [6582], 'India': [6583], 'discussions.': [6586]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024443281', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-12-14T02:27:19.855808', 'created_date': '2016-06-24'}