Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

Name: Work Video:
Duration: 3 min 30 s
Shinichi Itoh; Ha Won Kim; Osamu Nakagawa; Kiyoshi Ozumi; Susan M. Lessner; Hiroki Aoki; Kamran Akram; Ronald McKinney; Masuko Ushio‐Fukai; Tohru Fukai
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['https://openalex.org/W3115309223', 'https://openalex.org/W3004638618', 'https://openalex.org/W2234831416', 'https://openalex.org/W2138786316', 'https://openalex.org/W2132532293', 'https://openalex.org/W2094831461', 'https://openalex.org/W2076660617', 'https://openalex.org/W2035906232', 'https://openalex.org/W1979576412', 'https://openalex.org/W1977174457'], 'abstract_inverted_index': {'Copper': [0, 22, 223, 245, 446, 1653, 3654], 'plays': [1, 224, 537, 1016, 1391], 'a': [2, 51, 55, 104, 139, 202, 225, 274, 278, 327, 362, 425, 459, 538, 1057, 1062, 1077, 1367, 1460, 1577, 1821, 1996, 2052, 2156, 2201, 2230, 2429, 3184, 3283, 3335, 3748, 3803, 3827, 3958, 3973, 4003, 4125, 4132], 'fundamental': [3, 226, 539], 'role': [4, 175, 227, 398, 540, 1019, 1394], 'in': [5, 40, 89, 109, 126, 142, 157, 189, 228, 263, 312, 332, 349, 365, 380, 412, 452, 477, 541, 546, 559, 808, 816, 983, 1020, 1224, 1227, 1339, 1352, 1395, 1471, 1510, 1517, 1527, 1536, 1543, 1553, 1619, 1655, 1668, 1692, 1710, 1753, 2137, 2213, 2459, 2518, 2583, 2602, 2660, 2721, 2758, 2793, 2802, 2877, 3049, 3170, 3334, 3351, 3364, 3375, 3454, 3469, 3477, 3518, 3651, 3673, 3687, 3694, 3711, 3725, 3734, 3776, 3802, 3806, 3811, 3832, 3845, 3883, 3914, 3928, 3972, 3982, 4002, 4006, 4019, 4038, 4045, 4069, 4113, 4179, 4210, 4230, 4249, 4308], 'regulating': [6, 229, 542, 1340, 4081], 'cell': [7, 34, 63, 75, 144, 196, 221, 230, 257, 286, 298, 367, 419, 444, 543, 817, 1021, 1342, 1350, 1380, 1401, 1694, 2942, 3332, 3346, 3384, 3445, 3550, 3638, 3675, 3679, 3692, 3726, 3896, 3950], 'growth.': [8, 231], 'Many': [9, 232], 'types': [10, 233], 'of': [11, 66, 129, 136, 176, 186, 234, 289, 352, 359, 399, 409, 461, 511, 524, 602, 615, 974, 1066, 1110, 1180, 1231, 1371, 1416, 1590, 1598, 1728, 1776, 1843, 1883, 1957, 1961, 1983, 2065, 2084, 2099, 2102, 2162, 2189, 2248, 2289, 2316, 2327, 2365, 2374, 2538, 2568, 2586, 2614, 2622, 2636, 2644, 2724, 2729, 2761, 2767, 2783, 2805, 2833, 2880, 2957, 2984, 3094, 3120, 3126, 3135, 3166, 3187, 3199, 3202, 3239, 3301, 3310, 3323, 3362, 3372, 3381, 3399, 3452, 3460, 3528, 3558, 3722, 3745, 3751, 3799, 3843, 3903, 3917, 3921, 3934, 4027, 4033, 4055, 4060, 4162, 4203, 4261, 4285], 'human': [12, 235, 1417, 2056], 'cancer': [13, 149, 236, 372, 809], 'tissues': [14, 237, 821, 3472], 'have': [15, 36, 238, 259, 812], 'higher': [16, 239, 813], 'copper': [17, 52, 72, 98, 119, 160, 240, 275, 295, 321, 342, 383, 536, 814, 866, 978, 1015, 1079, 1083, 1348, 1360, 3326, 3382, 3453, 3462, 3516, 3525, 3531, 3685, 3793, 3820, 3948, 4068, 4307], 'levels': [18, 241, 815, 3798], 'than': [19, 242, 819], 'normal': [20, 243, 820, 2972], 'tissues.': [21, 244], 'can': [23, 246], 'also': [24, 247, 1357, 3267, 3817], 'induce': [25, 248], 'gene': [26, 249, 3731, 3985, 3989], 'expression.': [27, 250, 3986], 'However,': [28, 251], 'transcription': [29, 58, 204, 252, 281, 427], 'factors': [30, 253], 'that': [31, 45, 60, 97, 118, 184, 254, 268, 283, 320, 341, 407, 465, 535, 1014, 1060, 1081, 1220, 1333, 1347, 1359, 1388, 3515, 3548, 3644, 3684, 3741, 3819, 3947, 3992, 4053, 4077, 4118, 4219, 4241, 4277, 4300], 'mediate': [32, 255], 'copper-induced': [33, 62, 195, 256, 285, 418, 1341, 3345, 3549, 3637], 'proliferation': [35, 258, 1351, 3347, 3385, 3446, 3551, 3639, 3897, 3922, 3951], 'not': [37, 260, 3641, 3649, 3810, 3872, 3881, 3907, 3942, 3995, 4142, 4150, 4269], 'been': [38, 261, 1074], 'identified': [39, 262, 4041], 'mammals.': [41, 264], 'Here': [42, 265, 1344], 'we': [43, 266, 1218, 1345, 1383, 2191, 3677, 3729, 4110, 4254, 4328], 'show': [44, 267, 1346, 1384], 'antioxidant-1': [46, 269, 1296], '(Atox1),': [47, 270], 'previously': [48, 105, 271, 328, 1481, 1630, 2021, 2332], 'appreciated': [49, 272, 1075], 'as': [50, 201, 273, 424, 458, 551, 556, 558, 1076, 1480, 1629, 1661, 1852, 1860, 2020, 2211, 2321, 2331, 2369, 2371, 3282, 3291, 3356, 3358, 3837, 3839, 3887, 4124], 'chaperone,': [53, 276], 'represents': [54, 277, 4283], 'novel': [56, 203, 279, 426, 1368], 'copper-dependent': [57, 140, 280, 363], 'factor': [59, 205, 282, 428], 'mediates': [61, 284], 'proliferation.': [64, 197, 222, 287, 420, 445, 1343, 1381, 1402], 'Stimulation': [65, 288], 'mouse': [67, 290, 1299, 1612, 2139, 2475], 'embryonic': [68, 291, 1041, 1300, 1613, 2476], 'fibroblasts': [69, 292, 1301], '(MEFs)': [70, 293, 1616], 'with': [71, 294, 1549, 1559, 1576, 1595, 1624, 1673, 1715, 1779, 1797, 2000, 2155, 2412, 2471, 2566, 2715, 2746, 2751, 2829, 2853, 2922, 2954, 2968, 3000, 3024, 3076, 3091, 3158, 3207, 3260, 3269, 3325, 3780, 4187], 'markedly': [73, 296, 3330, 3795], 'increased': [74, 297, 3331, 3691, 3796], 'proliferation,': [76, 299, 3676], 'cyclin': [77, 111, 300, 334, 1373, 1397, 1889, 2057, 2104, 2717, 2770, 3167, 3189, 3746, 3800, 3823, 3868, 3888, 3891, 3904, 3908, 3936, 3939, 3954, 3983, 3999, 4035, 4061, 4082, 4134, 4232, 4251, 4325, 4335], 'D1': [78, 112, 301, 335, 1374, 1398, 1890, 2058, 2105, 2405, 2718, 2771, 3168, 3190, 3661, 3801, 3824, 3869, 3937, 3955, 3970, 3984, 4000, 4036, 4062, 4083, 4135, 4233, 4252, 4326, 4336], 'expression,': [79, 302, 3826], 'and': [80, 94, 148, 168, 216, 303, 317, 371, 391, 439, 456, 474, 508, 554, 566, 599, 810, 871, 967, 1023, 1072, 1107, 1178, 1376, 1400, 1515, 1532, 1557, 1572, 1584, 1592, 1601, 1606, 1609, 1689, 1736, 1750, 1795, 1835, 1885, 1892, 1899, 1917, 1971, 1986, 2062, 2093, 2127, 2149, 2167, 2200, 2220, 2305, 2325, 2386, 2431, 2521, 2552, 2599, 2619, 2664, 2688, 2863, 2896, 3047, 3087, 3097, 3104, 3132, 3194, 3229, 3248, 3255, 3340, 3392, 3473, 3538, 3567, 3575, 3736, 3877, 3890, 3966, 4011, 4022, 4076, 4093, 4169, 4297, 4315], 'entry': [81, 304], 'into': [82, 305, 2108, 2129, 2152, 2222, 2298, 2409, 2860], 'S': [83, 306, 3696], 'phase,': [84, 307], 'which': [85, 308, 1088, 1233, 1276, 3466, 3571, 3669, 3708, 3783, 3829, 4183], 'were': [86, 309, 1478, 1524, 1547, 1574, 1617, 1666, 1681, 1690, 1708, 1721, 1756, 1771, 1792, 1815, 1845, 1993, 2006, 2075, 2123, 2169, 2216, 2329, 2378, 2390, 2407, 2468, 2481, 2497, 2515, 2570, 2574, 2649, 2680, 2713, 2785, 2800, 2815, 2827, 2850, 2875, 2905, 2966, 2978, 2997, 3073, 3102, 3140, 3156, 3173, 3180, 3204, 3212, 3252, 3266, 3296, 3314, 4122, 4191, 4197], 'completely': [87, 310], 'abolished': [88, 311, 3831, 3899], 'Atox1-/-': [90, 190, 313, 413, 1751, 3352, 3376, 3455, 3712, 3737, 3777, 3812, 3833, 4020, 4070], 'MEFs.': [91, 314, 3738, 4263], 'Promoter': [92, 315, 3971], 'analysis': [93, 316, 1865, 2017, 3300, 3733, 4032], 'EMSA': [95, 318, 2608, 2696, 4330], 'revealed': [96, 319], 'stimulates': [99, 120, 322, 343, 1349, 3949], 'the': [100, 110, 124, 133, 155, 173, 182, 193, 323, 333, 347, 356, 378, 396, 405, 416, 972, 1067, 1085, 1090, 1225, 1228, 1267, 1279, 1326, 1331, 1372, 1385, 1426, 1545, 1560, 1744, 1760, 1774, 1801, 1809, 1848, 1855, 1869, 1955, 1958, 1980, 1984, 2103, 2109, 2130, 2141, 2172, 2181, 2186, 2196, 2205, 2237, 2245, 2287, 2299, 2363, 2366, 2372, 2375, 2394, 2400, 2417, 2439, 2491, 2508, 2533, 2539, 2584, 2683, 2700, 2722, 2730, 2735, 2759, 2768, 2803, 2819, 2917, 3114, 3143, 3159, 3171, 3188, 3236, 3249, 3272, 3279, 3305, 3379, 3519, 3524, 3666, 3695, 3718, 3742, 3915, 3919, 3968, 3998, 4034, 4042, 4056, 4088, 4173, 4185, 4211, 4224, 4231, 4244, 4250, 4278, 4288, 4324], 'Atox1': [101, 121, 130, 152, 178, 188, 199, 324, 344, 353, 375, 401, 411, 422, 1221, 1264, 1335, 1362, 1390, 1406, 1418, 1434, 1439, 2072, 2142, 2164, 2193, 2209, 2227, 2291, 2317, 2637, 2748, 3363, 3374, 3522, 3529, 3670, 3723, 3844, 3963, 3979, 4240, 4286, 4301, 4320], 'binding': [102, 122, 325, 345, 1365, 2466, 2604, 2645, 4177, 4284, 4302], 'to': [103, 123, 132, 154, 159, 220, 326, 346, 355, 377, 382, 443, 1084, 1173, 1329, 1366, 1411, 1433, 1566, 1743, 1762, 1808, 2069, 2180, 2195, 2244, 2307, 2399, 2416, 2433, 2490, 2507, 2523, 2531, 2672, 2682, 2699, 2734, 2787, 2841, 2844, 3112, 3142, 3182, 3232, 3257, 3479, 3533, 3702, 3857, 3965, 4067, 4107, 4175, 4223, 4227, 4243, 4247, 4287, 4291, 4303, 4323], 'undescribed': [106, 329], 'cis': [107, 330, 1369], 'element': [108, 331, 451, 1370, 4090], 'promoter.': [113, 336, 4234], 'The': [114, 337, 1421, 1876, 2047, 2159, 2403, 2536, 2941, 2963, 3177, 3246, 3263, 4152, 4193, 4334], 'ChIP': [115, 338, 2813, 2822], 'assay': [116, 339, 1310, 1319, 2823], 'confirms': [117, 340], 'DNA': [125, 214, 348, 437, 2502, 2618, 2627, 2845, 3154], 'vivo.': [127, 350], 'Transfection': [128, 351, 2385], 'fused': [131, 354, 2194, 2243], 'DNA-binding': [134, 357, 2198], 'domain': [135, 358, 2188, 2199], 'Gal4': [137, 360], 'demonstrated': [138, 180, 361, 403, 3991], 'transactivation': [141, 364, 2187], 'various': [143, 366, 560, 2160], 'types,': [145, 368], 'including': [146, 369, 469, 562, 3475], 'endothelial': [147, 370, 1693], 'cells.': [150, 373, 2478, 4115], 'Furthermore,': [151, 374, 964, 3450, 3792], 'translocated': [153, 376], 'nucleus': [156, 379, 1226], 'response': [158, 381, 3828, 3854, 3879, 4016, 4066], 'through': [161, 384, 3535, 3663, 3957], 'its': [162, 385, 981, 1273, 2293, 3559], 'highly': [163, 386, 1235], 'conserved': [164, 387, 1068, 1268], 'C-terminal': [165, 388], 'KKTGK': [166, 389], 'motif': [167, 390], 'N-terminal': [169, 392, 1064], 'copper-binding': [170, 393, 1058, 1070], 'sites.': [171, 394, 2207], 'Finally,': [172, 395], 'functional': [174, 397], 'nuclear': [177, 212, 400, 435, 1280, 1320, 1334, 1363, 2472, 2485, 2623, 2704, 2731, 2741, 3247, 3280, 4102, 4220, 4259], 'is': [179, 402, 447, 1027, 1056, 1222, 3395, 3467, 3556, 3671, 3980, 4239], 'by': [181, 209, 404, 432, 977, 1663, 1758, 1773, 1817, 1854, 1936, 1968, 2008, 2088, 2125, 2147, 2171, 2218, 2380, 2438, 2739, 2817, 2946, 2980, 3146, 3175, 3298, 3304, 3359, 3658, 3668, 3787, 3840, 3900, 3925, 3931, 3952, 4025, 4131, 4143, 4158, 4199], 'observation': [183, 406], 're-expression': [185, 408, 4026], 'nuclear-targeted': [187, 410, 1389, 2226], 'MEFs': [191, 414, 1729, 3324, 3353, 3367, 3476, 3813, 3834, 3930, 4008], 'rescued': [192, 415, 3378, 3457, 4024], 'defective': [194, 417], 'Thus,': [198, 421], 'functions': [200, 423], 'that,': [206, 429], 'when': [207, 430], 'activated': [208, 431, 3540], 'copper,': [210, 433, 3858, 3918, 3993], 'undergoes': [211, 434], 'translocation,': [213, 436, 1364], 'binding,': [215, 438], 'transactivation,': [217, 440, 1377], 'thereby': [218, 441, 1378], 'contributing': [219, 442], 'an': [448, 1017, 1353, 1392, 1408, 1733, 1831, 1836, 1926, 3396, 3706, 4078], 'essential': [449, 1018, 1393], 'trace': [450], 'all': [453, 2361, 4054], 'living': [454], 'organisms': [455], 'serves': [457], 'cofactor': [460], 'key': [462, 3749], 'metabolic': [463], 'enzymes': [464], 'regulate': [466], 'physiological': [467, 547, 3328], 'processes,': [468], 'cellular': [470], 'respiration,': [471], 'antioxidant': [472], 'defense,': [473], 'iron': [475, 3863], 'metabolism': [476], 'eukaryocytes': [478], '(1Pena': [479, 570], 'M.M.': [480, 571], 'Lee': [481, 572], 'J.': [482, 485, 573, 576, 625, 690, 707, 1128, 1154, 1195, 1197, 1635, 2344, 3429, 3617], 'Thiele': [483, 574], 'D.J.': [484, 575], 'Nutr.': [486, 577, 750, 910, 1002, 3503], '1999;': [487, 578, 1290], '129:': [488, 579], '1251-1260Crossref': [489, 580], 'PubMed': [490, 581, 631, 670, 698, 712, 729, 743, 755, 799, 842, 860, 889, 903, 915, 959, 995, 1007, 1139, 1165, 1212, 1257, 1293, 1454, 1502, 1648, 2042, 2261, 2281, 2355, 3416, 3438, 3492, 3507, 3604, 3628, 3768], 'Scopus': [491, 582, 632, 671, 699, 713, 730, 744, 800, 843, 861, 890, 904, 960, 996, 1140, 1166, 1213, 1258, 1455, 1503, 1649, 2043, 2262, 2282, 2356, 3417, 3493, 3508, 3605, 3629, 3769], '(612)': [492, 583], 'Google': [493, 584, 634, 647, 673, 701, 715, 732, 746, 756, 802, 831, 845, 863, 892, 906, 916, 962, 998, 1008, 1142, 1168, 1215, 1260, 1294, 1457, 1505, 1651, 2045, 2264, 2284, 2358, 3419, 3439, 3495, 3510, 3607, 3631, 3771], 'Scholar,': [494, 518, 585, 609, 622, 635, 648, 674, 702, 716, 733, 747, 757, 832, 846, 893, 907, 917, 999, 1117, 1143, 2265, 3420, 3496, 3608], '2Culotta': [495, 586], 'V.C.': [496, 587, 1095, 1153], 'Gitlin': [497, 588, 1096, 1126, 1200, 1636, 2342, 3499], 'J.D.': [498, 589, 1097, 1127, 1201, 1637, 2343, 3500], 'Scriver': [499, 590, 1098], 'C.R.': [500, 591, 1099], 'Beaudet': [501, 592, 1100], 'A.L.': [502, 593, 1101], 'Sly': [503, 594, 1102], 'W.S.': [504, 595, 1103], 'Vale': [505, 596, 1104], 'D.': [506, 597, 765, 825, 925, 1105, 1284, 2267, 3408], 'Molecular': [507, 598, 1106], 'Metabolic': [509, 600, 1108], 'Basis': [510, 601, 1109], 'Inherited': [512, 603, 1111], 'Disease.': [513, 604, 1112], 'McGraw-Hill,': [514, 605, 1113], 'New': [515, 528, 606, 619, 1114], 'York2001:': [516, 607, 1115], '3105-3126Google': [517, 608, 1116], '3Linder': [519, 610], 'M.C.': [520, 522, 611, 613], 'Linder': [521, 612], 'Biochemistry': [523, 614], 'Copper.': [525, 616], 'Plenum': [526, 617], 'Press,': [527, 618], 'York1991:': [529, 620], '1-13Google': [530, 621], 'Scholar).': [531, 803, 963, 1009, 1169, 1216, 1261, 1295, 1506, 1652, 2046, 2285, 2359, 3511], 'Accumulating': [532], 'evidence': [533, 1387], 'suggest': [534, 1013, 3946], 'growth': [544, 870, 1022, 1188, 1695, 1754, 3573], 'involved': [545, 1338, 3650, 3672, 3724, 3981], 'repair': [548], 'processes': [549], 'such': [550, 3886], 'wound': [552], 'healing': [553], 'angiogenesis': [555], 'well': [557, 2370, 3357, 3838], 'pathophysiologies': [561], 'tumor': [563, 869], 'growth,': [564], 'atherosclerosis,': [565, 1232], 'neuron': [567], 'degenerative': [568], 'diseases': [569], '4Hu': [623], 'G.F.': [624], 'Cell.': [626, 1288, 2256, 2274, 3409], 'Biochem.': [627, 3485], '1998;': [628, 1131, 2347, 3620], '69:': [629], '326-335Crossref': [630], '(358)': [633], '5McAuslan': [636], 'B.R.': [637], 'Gole': [638], 'G.A.': [639], 'Trans.': [640], 'Ophthalmol': [641], 'Soc.': [642], 'UK.': [643], '1980;': [644], '100:': [645, 797, 957, 1646], '354-358PubMed': [646], '6Volker': [649], 'W.': [650], 'Dorszewski': [651], 'A.': [652, 761, 795, 921, 955, 1149, 1193, 1208, 1644], 'Unruh': [653], 'V.': [654, 769, 778, 929, 938, 1239, 2024], 'Robenek': [655], 'H.': [656], 'Breithardt': [657], 'G.': [658, 1123, 2339], 'Buddecke': [659], 'E.': [660], 'Atherosclerosis.': [661], '1997;': [662, 1157], '130:': [663], '29-36Abstract': [664], 'Full': [665, 667, 1134, 1136, 1160, 1162, 2278, 2350, 2352, 3413, 3435, 3623, 3625], 'Text': [666, 668, 1135, 1137, 1161, 1163, 2279, 2351, 2353, 3414, 3436, 3624, 3626], 'PDF': [669, 1138, 1164, 2280, 2354, 3415, 3437, 3627], '(37)': [672], '7Sen': [675], 'C.K.': [676], 'Khanna': [677], 'S.': [678, 688, 763, 784, 794, 923, 944, 954, 1207, 1241, 1492, 1643, 2026, 3404], 'Venojarvi': [679], 'M.': [680, 782, 823, 942, 1243, 1247, 1484, 2028, 2032, 3580, 3590, 3610, 3614, 3755], 'Trikha': [681], 'P.': [682, 1199, 3402], 'Ellison': [683], 'E.C.': [684], 'Hunt': [685], 'T.K.': [686], 'Roy': [687], 'Am.': [689], 'Physiol.': [691, 694], 'Heart': [692], 'Circ.': [693, 1252, 2037, 3599], '2002;': [695, 1451, 3504, 3601], '282:': [696], 'H1821-H1827Crossref': [697], '(377)': [700], '8Birkaya': [703], 'B.': [704], 'Aletta': [705], 'J.M.': [706], 'Neurobiol.': [708], '2005;': [709, 740, 900, 992, 1254, 2039], '63:': [710], '49-61Crossref': [711], '(42)': [714], '9Goodman': [717], 'V.L.': [718, 878], 'Brewer': [719, 879], 'G.J.': [720, 735, 880, 895, 987], 'Merajver': [721, 881], 'S.D.': [722, 882, 1442], 'Endocr.': [723, 883], 'Relat.': [724, 884], 'Cancer.': [725, 885], '2004;': [726, 752, 857, 886, 912, 1004, 3765], '11:': [727, 887], '255-263Crossref': [728, 888], '(143)': [731, 891], '10Brewer': [734, 894], 'Curr.': [736, 896, 988], 'Cancer': [737, 826, 897, 989], 'Drug': [738, 898, 990], 'Targets.': [739, 899, 991], '5:': [741, 901, 993], '195-202Crossref': [742, 902, 994], '(63)': [745, 905, 997], '11Harris': [748, 908, 1000], 'E.D.': [749, 776, 909, 936, 1001], 'Rev.': [751, 911, 1003, 3502], '62:': [753, 913, 1005], '60-64Crossref': [754, 914, 1006], '12Mandinov': [758, 918], 'L.': [759, 919, 1490, 2252], 'Mandinova': [760, 920], 'Kyurkchiev': [762, 764, 922, 924], 'Kehayov': [766, 926], 'I.': [767, 786, 927, 946, 1191, 1633], 'Kolev': [768, 928], 'Soldi': [770, 930], 'R.': [771, 931, 3406], 'Bagala': [772, 932], 'C.': [773, 933, 2254, 3596, 3757], 'de': [774, 835, 934], 'Muinck': [775, 935], 'Lindner': [777, 937], 'Post': [779, 939], 'M.J.': [780, 940], 'Simons': [781, 941], 'Bellum': [783, 943], 'Prudovsky': [785, 945], 'Maciag': [787, 947], 'T.': [788, 948, 1251, 2036, 3584, 3761], 'Proc.': [789, 949, 1202, 1638], 'Natl.': [790, 950, 1203, 1639], 'Acad.': [791, 951, 1204, 1640], 'Sci.': [792, 952, 1205, 1641], 'U.': [793, 953, 1206, 1642], '2003;': [796, 956, 1645], '6700-6705Crossref': [798, 958], '(107)': [801, 961], 'Of': [804, 1262, 3562, 3851], 'note,': [805, 1263, 3563, 3852], 'hyperproliferative': [806], 'lesions': [807, 1230], 'atherosclerosis': [811], 'nuclei': [818], '(13Arnold': [822], 'Sasse': [824], 'Res.': [827, 1253, 2038, 3487, 3600], '1961;': [828], '21:': [829, 1500], '761-766PubMed': [830], '14Fuchs': [833], 'A.G.': [834], 'Lustig': [836], 'E.S.': [837], 'Oncology.': [838], '1989;': [839], '46:': [840], '183-187Crossref': [841], '(30)': [844], '15Daniel': [847], 'K.G.': [848], 'Harbach': [849], 'R.H.': [850], 'Guida': [851], 'W.C.': [852], 'Dou': [853], 'Q.P.': [854], 'Front': [855], 'Biosci.': [856], '9:': [858], '2652-2662Crossref': [859], '(127)': [862], 'Scholar),': [864, 3772], 'while': [865], 'chelation': [867, 979], 'prevents': [868], 'neointimal': [872], 'thickening': [873], 'after': [874, 1176, 1508, 2422], 'vascular': [875], 'injury': [876], '(9Goodman': [877], 'Phase': [965], 'I': [966], 'II': [968, 2174], 'clinical': [969], 'trials': [970], 'for': [971, 1723, 1766, 1788, 1888, 1895, 1932, 1942, 1947, 2525, 2577, 2657, 2743, 2835, 2865, 2898, 2909, 2951, 2990, 3109, 3148, 3218, 3226, 3243, 4207, 4266], 'treatment': [973, 3686, 3794], 'solid': [975], 'tumors': [976], 'showed': [980], 'efficacy': [982], 'disease': [984], 'stabilization': [985], '(10Brewer': [986], 'These': [1010, 3545, 3944], 'observations': [1011], 'strongly': [1012], 'proliferation;': [1024], 'however,': [1025], 'little': [1026], 'known': [1028], 'about': [1029, 3926], 'underlying': [1030], 'molecular': [1031], 'mechanisms.': [1032], 'Antioxidant-1': [1033], '(Atox1)': [1034], '3The': [1035], 'abbreviations': [1036], 'used': [1037, 2050, 2192, 2306, 2541, 3181], 'are:': [1038], 'Atox1antioxidant-1PBSphosphate-buffered': [1039], 'salineMEFsmouse': [1040], 'fibroblastsFBSfetal': [1042], 'bovine': [1043, 1303, 1540, 1627, 1702, 1907], 'serumTricineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGSTglutathione': [1044], 'S-transferaseChIPchromatin': [1045], 'immunoprecipitation': [1046, 1309], 'assayWTwild': [1047], 'typeBCSbathocuproine': [1048], 'disulfonic': [1049, 1314], 'acidEMSAelectrophoretic': [1050], 'mobility': [1051, 1317], 'shift': [1052, 1318], 'assayNLSnuclear': [1053], 'localization': [1054, 1281, 1321], 'signal.': [1055, 1322], 'protein': [1059, 1265, 1440, 2732, 3825], 'contains': [1061], 'single': [1063], 'copy': [1065], 'MXCXXC': [1069], 'motif,': [1071], 'has': [1073, 1266], 'cytosolic': [1078], 'chaperone': [1080, 3526, 3560], 'delivers': [1082], 'secretory': [1086, 3461], 'compartment,': [1087], 'includes': [1089], 'trans-Golgi': [1091], 'network': [1092], '(TGN)': [1093], '(2Culotta': [1094], '16Hung': [1118], 'I.H.': [1119, 2335], 'Casareno': [1120, 2336], 'R.L.': [1121, 2337], 'Labesse': [1122, 2338], 'Mathews': [1124, 2340], 'F.S.': [1125, 2341], 'Biol.': [1129, 1155, 1289, 1498, 2257, 2345, 3430, 3618], 'Chem.': [1130, 1156, 2346, 3431, 3619], '273:': [1132, 2348, 3621], '1749-1754Abstract': [1133, 2349], '(128)': [1141, 2357], '17Lin': [1144], 'S.J.': [1145], 'Pufahl': [1146], 'R.A.': [1147], 'Dancis': [1148], "O'Halloran": [1150], 'T.V.': [1151], 'Culotta': [1152], '272:': [1158], '9215-9220Abstract': [1159], '(353)': [1167], 'Atox1-deficient': [1170], 'mice': [1171], 'failed': [1172], 'thrive': [1174], 'immediately': [1175], 'birth,': [1177], '45%': [1179], 'pups': [1181], 'died': [1182], 'before': [1183, 2669, 2846], 'weaning.': [1184], 'Surviving': [1185], 'animals': [1186], 'exhibited': [1187], 'failure': [1189], '(18Hamza': [1190], 'Faisst': [1192], 'Prohaska': [1194, 1634], 'Chen': [1196], 'Gruss': [1198], '2001;': [1209, 1499], '98:': [1210], '6848-6852Crossref': [1211], '(174)': [1214], 'Recently,': [1217], 'found': [1219, 3683, 3740, 4117], 'expressed': [1223, 3290, 3468], 'intimal': [1229], 'contain': [1234], 'proliferating': [1236], 'cells': [1237, 1474, 1521, 1546, 1573, 1615, 1707, 1720, 1752, 1770, 2410, 2784, 2799, 2849, 2904, 3377, 3456, 3474, 3520, 3689, 3713, 3778, 3847, 4021, 4040, 4071], '(19Jeney': [1238, 2023], 'Itoh': [1240, 2025], 'Wendt': [1242, 2027], 'Gradek': [1244, 2029], 'Q.': [1245, 2030], 'Ushio-Fukai': [1246, 2031], 'Harrison': [1248, 2033], 'D.G.': [1249, 2034], 'Fukai': [1250, 2035, 3583], '96:': [1255, 2040], '723-729Crossref': [1256, 2041], '(60)': [1259, 2044], 'lysine-rich': [1269], 'region': [1270, 2144, 2295, 3186, 4044, 4080, 4186, 4212, 4225, 4245, 4289, 4305], '(KKTGK)': [1271], 'at': [1272, 1929, 1939, 1954, 1979, 1990, 2451, 2528, 2580, 2666, 2685, 2838, 2868, 2871, 2948, 2993, 3106, 3151, 3215, 3223, 3327, 3569], 'C': [1274, 2246], 'terminus,': [1275], 'may': [1277, 1336], 'represent': [1278], 'signal': [1282], '(20Palmeri': [1283], 'Malim': [1285], 'M.H.': [1286], 'Mol.': [1287, 2255], '19:': [1291], '1218-1225Crossref': [1292], 'phosphate-buffered': [1297], 'saline': [1298], 'fetal': [1302, 1626, 1701], 'serum': [1304, 1541, 1555, 1628, 1672, 1703, 1908], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine': [1305], 'glutathione': [1306], 'S-transferase': [1307], 'chromatin': [1308], 'wild': [1311], 'type': [1312], 'bathocuproine': [1313], 'acid': [1315], 'electrophoretic': [1316], 'We': [1323, 1356, 3682, 3739, 3816, 4051, 4116], 'thus': [1324, 3539], 'performed': [1325, 1667, 1731, 1867, 1978, 2019, 2320, 2330, 2458, 2738, 2757, 2816, 3678, 3730, 4111, 4255, 4329], 'present': [1327], 'study': [1328], 'test': [1330, 4318], 'hypothesis': [1332], 'be': [1337], 'Atox1-dependent': [1354, 3878], 'manner.': [1355], 'demonstrate': [1358], 'induces': [1361], 'promoter': [1375, 2106, 2719, 2772, 2776, 3169, 4001, 4037, 4063, 4084, 4136], 'promoting': [1379], 'Moreover,': [1382, 3874], 'direct': [1386], 'copper-stimulated': [1396, 3674], 'expression': [1399, 2011, 2117, 2301, 3732, 3870, 3956], 'Antibody': [1403, 4264], 'Production—To': [1404], 'generate': [1405], 'antibody,': [1407], 'oligopeptide': [1409], 'corresponding': [1410], 'amino': [1412], 'acids': [1413], '49–62': [1414], '(DTLLATLKKTGKTV)': [1415], 'was': [1419, 1423, 1459, 1658, 1730, 1828, 1866, 1952, 1966, 1977, 2018, 2086, 2145, 2242, 2296, 2319, 2426, 2639, 2737, 2756, 2919, 2944, 3348, 3709, 3773, 3784, 3830, 3855, 3898, 3923, 4017, 4023, 4156], 'used.': [1420, 2571], 'antibody': [1422, 2054, 2638, 2749, 2970], 'affinity-purified': [1424], 'using': [1425, 1582, 1732, 1800, 1830, 1847, 1857, 1868, 2393, 2428, 2483, 2499, 2611, 2690, 4331], 'immobilized': [1427], 'peptide.': [1428], 'A': [1429, 3889, 4029], 'rabbit': [1430, 2066, 2753, 2973, 4271], 'polyclonal': [1431, 2067], 'antiserum': [1432], 'raised': [1435], 'against': [1436, 1995, 2055], 'purified': [1437, 2708, 3157], 'recombinant': [1438, 2290, 4332], '(21Moore': [1441], 'Helmle': [1443], 'K.E.': [1444], 'Prat': [1445], 'L.M.': [1446], 'Cox': [1447], 'D.W.': [1448], 'Mamm.': [1449], 'Genome.': [1450], '13:': [1452], '563-568Crossref': [1453], '(12)': [1456], 'Scholar)': [1458, 3632], 'kind': [1461], 'gift': [1462], 'from': [1463, 1683, 2236, 2450, 2474, 2706, 3698], 'Dr.': [1464], 'Diane': [1465], 'Cox.': [1466], 'Immunofluorescence': [1467], 'Studies—For': [1468], 'immunofluorescence': [1469, 2135], 'studies': [1470, 2136], 'cultured': [1472, 1618, 2138], 'cells,': [1473, 3782, 3808], 'on': [1475, 1522, 1820, 2077, 2901, 2913, 3383, 3444, 3636, 3867, 3961, 4258], 'glass': [1476], 'coverslips': [1477, 1523], 'processed': [1479], 'described': [1482, 1631, 1853, 2022, 2212, 2333], '(22Ushio-Fukai': [1483], 'Griendling': [1485, 3615], 'K.K.': [1486, 3616], 'Becker': [1487], 'P.L.': [1488], 'Hilenski': [1489], 'Halleran': [1491], 'Alexander': [1493, 3597, 3611], 'R.W.': [1494, 3598, 3612], 'Arterioscler.': [1495], 'Thromb.': [1496], 'Vasc.': [1497], '489-495Crossref': [1501], '(260)': [1504], 'Briefly,': [1507], 'fixation': [1509], 'freshly': [1511], 'prepared': [1512, 1999, 2482], '4%': [1513, 2653], 'paraformaldehyde': [1514], 'permeabilization': [1516], '0.2%': [1518], 'Triton': [1519, 2928, 3010, 3034], 'X-100,': [1520, 2929, 3011, 3035], 'rinsed': [1525, 1552, 2851], 'sequentially': [1526], 'PBS,': [1528], '50': [1529, 1902, 2587, 2888, 3092], 'mm': [1530, 2594, 2597, 2886, 2889, 2931, 2934, 2939, 3013, 3016, 3021, 3037, 3040, 3045, 3056, 3064, 3067, 3080, 3083], 'NH4Cl,': [1531], 'PBS.': [1533], 'After': [1534, 2511, 2796, 2915], 'incubation': [1535, 2947, 3147], 'blocking': [1537], 'buffer': [1538, 2605, 2882, 2924, 3006, 3030, 3054, 3078], '(3%': [1539], 'albumin': [1542], 'PBS),': [1544], 'incubated': [1548, 1558, 2714, 2801, 2897, 2967, 3214, 3222], 'primary': [1550, 2048], 'antibodies,': [1551], 'PBS/bovine': [1554], 'albumin,': [1556, 1909], 'appropriate': [1561], 'species-specific': [1562], 'secondary': [1563], 'antibodies': [1564, 2049], 'conjugated': [1565], 'fluorescein': [1567], 'isothiocyanate': [1568], 'or': [1569, 1784, 1894, 2562, 2630, 2633, 2710, 2726, 2750, 2763, 2774, 2809, 2971, 3221, 3275, 3938, 4146], 'rhodamine.': [1570], 'Cryosections': [1571], 'examined': [1575, 3977], 'Zeiss': [1578], 'LSM': [1579], '510': [1580], 'system,': [1581], 'argon': [1583], 'green': [1585], 'helium/neon': [1586], 'laser': [1587], 'excitation': [1588], 'lines': [1589], '488': [1591], '543': [1593], 'nm': [1594, 1660], 'emission': [1596], 'filters': [1597], 'BP': [1599], '500–550': [1600], 'LP': [1602], '560.': [1603], 'Cell': [1604, 1747, 3319, 3656], 'Culture': [1605], 'Nuclear': [1607, 1735, 2479, 3200], 'Fractionation—Atox1-/-': [1608], 'wild-type': [1610, 3365, 3929], 'immortalized': [1611], 'fibroblast': [1614, 2477], "Dulbecco's": [1620, 1711], 'modified': [1621, 1712], "Eagle's": [1622, 1713], 'medium': [1623, 1669, 1696, 1714, 1765, 3234], '10%': [1625, 1700, 1716], '(23Hamza': [1632], '1215-1220Crossref': [1647], '(144)': [1650], 'content': [1654], 'basal': [1656, 1764, 2794], 'media': [1657], '158': [1659], 'measured': [1662, 1953], 'ICP-MS.': [1664], 'Experiments': [1665], 'containing': [1670, 1699, 2204, 2856, 2893, 3235], '1%': [1671, 1777, 3009, 3033, 3058, 3060, 3095], 'no': [1674, 3634, 4065], 'additives.': [1675], 'Human': [1676], 'umbilical': [1677], 'vein': [1678], 'ECs': [1679], '(HUVECs)': [1680], 'purchased': [1682], 'VEC': [1684], 'Technologies,': [1685], 'Inc.': [1686], '(Rensselaer,': [1687], 'NY)': [1688], 'grown': [1691, 1709], '(EGMMV,': [1697], 'Clonetics)': [1698], '(FBS).': [1704], 'All': [1705], 'other': [1706, 3884], 'FBS.': [1717], 'Before': [1718], 'stimulation,': [1719], 'serum-starved': [1722], '24': [1724, 1767, 1789], 'h.': [1725, 1768, 1790], 'Nuclear/cytoplasmic': [1726], 'fractionation': [1727], 'NE-PER': [1734, 2484], 'Cytoplasmic': [1737], 'Extraction': [1738], 'Reagents': [1739], 'kit': [1740, 1806, 1834, 1850, 2177, 2504, 2824, 3162], '(Pierce)': [1741, 2488, 2505], 'according': [1742, 1807, 2179, 2398, 2415, 2489, 2506, 2698], "manufacturer's": [1745, 1810, 2182, 2401, 2418, 2492, 2509, 2701], 'protocol.': [1746, 2419, 2825], 'Cycle': [1748, 1803], 'Analysis—Wild-type': [1749], 'phase': [1755, 1960, 1982, 3697], 'synchronized': [1757], 'exposing': [1759], 'culture': [1761, 2791], 'FBS-deprived': [1763], 'Quiescent': [1769], 'stimulated': [1772, 3206, 3997], 'addition': [1775, 3451, 3478, 3517], 'FBS': [1778], 'either': [1780, 3935], '10': [1781, 1943, 1948, 2596, 2620, 2810, 2885, 2899, 2910, 3066, 3208, 3240], 'μm': [1782, 1786, 2807, 2811, 3209, 3241], 'CuCl2': [1783, 2725, 3242], '200': [1785, 1910, 2806], 'BCS': [1787, 2808], 'Cells': [1791, 2826, 2874], 'harvested,': [1793], 'fixed,': [1794], 'stained': [1796], 'propidium': [1798], 'iodide': [1799], 'BD': [1802], 'TEST™PLUS': [1804], 'Reagent': [1805], 'instructions': [1811], '(BD': [1812], 'Biosciences).': [1813], 'Samples': [1814], 'analyzed': [1816], 'flow': [1818], 'cytometry': [1819], 'FACSort': [1822], '(Becton-Dickinson).': [1823], 'Quantitative': [1824, 1862], 'Real-time': [1825], 'PCR—Total': [1826], 'RNA': [1827, 1844], 'isolated': [1829, 3254], 'RNeasy': [1832], 'mini': [1833], 'RNase-free': [1837], 'DNase': [1838], 'set': [1839], '(Qiagen).': [1840, 3163], '2': [1841, 2631, 3012, 3036, 3118], 'μg': [1842, 2621], 'reverse-transcribed': [1846], 'RETROscript': [1849], '(Ambion)': [1851], 'manufacturer,': [1856], 'random': [1858], 'hexamers': [1859], 'primer.': [1861], 'real-time': [1863, 3788], 'PCR': [1864, 2126, 2148, 2219, 3160, 3789], 'Light': [1870], 'Cycler': [1871], 'thermocycler': [1872], '(Roche': [1873], 'Applied': [1874], 'Science).': [1875], '10-μl': [1877], 'reaction': [1878], 'mixtures': [1879, 2648], 'contained': [1880], '0.3': [1881], 'mmol/liter': [1882, 1903], 'forward': [1884], 'reverse': [1886, 3113], 'primers': [1887, 3179], '(5′-CTGGCCATGAACTACCTGGA-3′': [1891], '5′-ATCCGCCTCTGGCATTTTGG-3′)': [1893], 'glyceraldehyde-3-phosphate': [1896, 2009], 'dehydrogenase': [1897, 2010], '(5′-TTCACCACCATGGAGAAGGC-3′': [1898], '5′-GGCATGGACTGTG': [1900], 'GTCATGA-3′),': [1901], 'KCl,': [1904], '250': [1905], 'μg/ml': [1906], 'μmol/liter': [1911], 'dNTPs,': [1912], '1:84,000': [1913], 'SYBR': [1914], 'Green': [1915], 'I,': [1916], '0.05': [1918, 3313], 'units/μl': [1919], 'TaqDNA': [1920], 'polymerase': [1921], '(Invitrogen).': [1922], 'Amplification': [1923, 2324], 'conditions': [1924], 'included': [1925, 2051], 'initial': [1927], 'denaturation': [1928], '95': [1930], '°C': [1931, 1941, 1946, 2530, 2840, 2950, 3108, 3217, 3225], '60': [1933], 's,': [1934, 1944], 'followed': [1935, 3145, 3303], '45': [1937, 2955, 2982, 3152], 'cycles': [1938], '65': [1940, 3107], '72': [1945], 's.': [1949], 'Cumulative': [1950], 'fluorescence': [1951], 'end': [1956], 'extension': [1959], 'each': [1962, 2457, 2912], 'cycle.': [1963], 'Product-specific': [1964], 'amplification': [1965], 'confirmed': [1967, 2087, 2379, 3786, 3818, 4052], 'melting': [1969], 'curve': [1970, 1998], 'agarose': [1972], 'gel': [1973], 'electrophoresis': [1974], 'analysis.': [1975, 3681], 'Quantification': [1976], 'log-linear': [1981], 'reaction,': [1985], 'cycle': [1987, 3680, 3727], 'numbers': [1988, 2782, 3333, 3693], 'obtained': [1989], 'this': [1991, 3652, 3853, 3875, 4108, 4304], 'point': [1992], 'plotted': [1994], 'standard': [1997], 'serially': [2001], 'diluted': [2002, 2920], 'control': [2003, 2441], 'samples.': [2004], 'Results': [2005, 2444], 'normalized': [2007, 2432], 'levels.': [2012], 'Western': [2013, 3258], 'Blot': [2014], 'Analysis—Western': [2015], 'blot': [2016], 'monoclonal': [2053], '(Santa': [2059], 'Cruz': [2060], 'Biotechnology)': [2061], 'two': [2063, 3089], 'kinds': [2064], 'antisera': [2068], 'Atox1.': [2070, 3962], 'For': [2071, 2134, 2225, 2286, 2556], 'detection,': [2073], 'samples': [2074], 'separated': [2076], '16.5%': [2078], 'Tricine-SDS/PAGE': [2079], 'gels': [2080, 2655], '(Bio-Rad).': [2081], 'Equal': [2082], 'loading': [2083, 3284], 'proteins': [2085, 2328, 2843, 4103, 4221], 'Ponceau': [2089], 'staining.': [2090], 'Plasmids,': [2091], 'Deletions,': [2092], 'Site-directed': [2094, 2314], 'Mutagenesis—The': [2095], 'promoter-reporter': [2096, 2118], 'constructs': [2097, 2119, 2406, 4059], 'consist': [2098], '5′': [2100, 4030, 4057], 'regions': [2101], 'inserted': [2107], 'luciferase': [2110, 2424, 2435], 'reporter': [2111, 3988], 'vector': [2112, 2132, 2302], 'pGL3-Basic': [2113, 2131], '(pGL3-Cyclin': [2114], 'D1–962/134).': [2115], 'Other': [2116], '(-735/104,': [2120], '-585/104,': [2121], '-495/104)': [2122], 'generated': [2124, 2170], 'subcloned': [2128, 2150, 2221], '(Promega).': [2133], 'fibroblasts,': [2140], 'coding': [2143, 2294], 'amplified': [2146, 2217], 'in-frame': [2151], 'pcDNA': [2153], '3.0': [2154], 'Flag': [2157], 'tag.': [2158], 'mutants': [2161, 4209], 'Flag-tagged': [2163, 2249], '(Flag-Atox1-ΔCT,': [2165], 'Flag-Atox1-K56,60E,': [2166], 'Flag-Atox1-C12,15S)': [2168], 'QuikChange': [2173], 'site-directed': [2175], 'mutagenesis': [2176, 2315], '(Stratagene)': [2178], 'protocols.': [2183, 2402], 'To': [2184, 3716, 4099, 4171, 4235, 4317], 'map': [2185, 4172], 'Atox1,': [2190, 3553, 4267], 'GAL4': [2197], 'luciferase-reporter': [2202], 'plasmid': [2203, 2442], 'Gal4-binding': [2206], 'Each': [2208], 'mutant': [2210], 'Fig.': [2214, 3369, 3448, 3543, 3849, 4013], '5A': [2215], 'pM-GAL4': [2223], 'DBD.': [2224], '(Flag-Atox1-NLS)': [2228], 'constructs,': [2229], 'tripartite': [2231], 'NLS': [2232], 'sequence': [2233, 2368], '(PKKKRKVD)': [2234], 'derived': [2235], 'SV40': [2238], 'large': [2239], 'T': [2240], 'antigen': [2241], 'terminus': [2247], 'WT-Atox1': [2250], '(24Fischer-Fantuzzi': [2251], 'Vesco': [2253], '1988;': [2258, 3410], '8:': [2259], '5495-5503Crossref': [2260], '(43)': [2263], '25Kalderon': [2266], 'Roberts': [2268], 'B.L.': [2269], 'Richardson': [2270], 'W.D.': [2271], 'Smith': [2272], 'A.E.': [2273], '1984;': [2275], '39:': [2276], '499-509Abstract': [2277], '(1868)': [2283], 'production': [2288, 3578], 'protein,': [2292], 'ligated': [2297], 'pGEX-4T-1': [2300], '(Amersham': [2303], 'Biosciences)': [2304], 'transform': [2308], 'Escherichia': [2309], 'coli': [2310], 'strain': [2311], 'BL21': [2312], '(DE3).': [2313], 'cDNA': [2318, 2367], 'mentioned': [2322], 'above.': [2323], 'purification': [2326, 3161], '(16Hung': [2334], 'In': [2360, 3388], 'cases,': [2362], 'fidelity': [2364], 'presence': [2373, 2585, 2723, 2760, 2804], 'intended': [2376], 'mutations': [2377, 4182], 'dideoxy': [2381], 'nucleotide': [2382, 4189], 'sequencing.': [2383], 'Transient': [2384], 'Reporter': [2387], 'Assay—Transfection': [2388], 'assays': [2389, 2467, 2814, 3990, 4257], 'carried': [2391, 2469, 2575], 'out': [2392, 2470, 2576], 'Polyfect': [2395], 'reagent': [2396, 2487], '(Qiagen)': [2397], 'pGL3-cyclin': [2404], 'transfected': [2408], 'along': [2411], 'pRL-TK': [2413], '(Promega)': [2414], 'Two': [2420], 'days': [2421], 'transfection,': [2423], 'activity': [2425, 2436, 3527, 4085], 'assayed': [2427], 'luminometer': [2430], 'Renilla': [2434], 'produced': [2437, 4123], 'co-transfected': [2440], 'pRL-CMV.': [2443], 'shown': [2445], 'are': [2446, 3289, 3648], 'means': [2447], '±': [2448, 3293, 3700, 3704], 'S.E.': [2449, 3294], 'least': [2452], 'three': [2453], 'independent': [2454, 3557], 'transfection': [2455], 'experiments,': [2456, 2558], 'quadruplicate.': [2460], 'Electrophoretic': [2461], 'Mobility': [2462], 'Shift': [2463], 'Assays': [2464], '(EMSAs)—DNA-protein': [2465], 'extracts': [2473, 2480, 2705, 2742, 4260], 'extraction': [2486], 'directions.': [2493], 'Synthetic': [2494], 'complementary': [2495, 2513], 'oligonucleotides': [2496, 2540], '3′-biotinylated': [2498], 'biotin': [2500, 2615], '3′-end': [2501], 'labeling': [2503], 'instructions.': [2510, 2702], 'labeling,': [2512], 'strands': [2514], 'mixed': [2516], 'together': [2517], 'equimolar': [2519], 'ratio': [2520], 'allowed': [2522, 2786], 'anneal': [2524], '1': [2526, 2634, 2952, 2991, 3063, 3082, 3127, 3149, 3227], 'h': [2527, 2953, 2992, 3111, 3150], '37': [2529, 2839, 3216, 3224], 'form': [2532], 'double-stranded': [2534], 'probe.': [2535], 'sequences': [2537, 3165], 'were:': [2542], '5′-GTCCTTGCATGCTAAATTAGTTCTTGCAAT-3′': [2543], '(probe1': [2544], '-585/-556),': [2545], '5′-TTCTTGCAATTTACACGTGTTAATGAAAAT-3′': [2546], '(probe2': [2547], '-565/-536),': [2548], '5′-TAATGAAAATGAAAGAAGATGCAGTCGCTG-3′': [2549, 2559], '(probe3': [2550, 2560, 2564], '-545/-516),': [2551], '5′-GCAGTCGCTGAGATTCTTTGGCCGTCTGTC-3′': [2553], '(probe4': [2554], '-525/-496).': [2555], 'competition': [2557], '-545/-516)': [2561], '5′-TAATGAAAATTCCCTCAGATGCAGTCGCTG-3′': [2563], '-545/-516': [2565, 4138, 4164], 'mutation': [2567], '-535/-530)': [2569], 'Binding': [2572], 'reactions': [2573], '20': [2578, 2612, 2642, 3015, 3039], 'min': [2579, 2659, 2745, 2837, 2867, 2900, 3220, 3228], 'room': [2581], 'temperature': [2582], 'ng/μl': [2588], 'poly(dI-dC),': [2589], '0.05%': [2590], 'Nonidet': [2591], 'P-40,': [2592], '5': [2593], 'MgCl2,': [2595], 'EDTA,': [2598, 2887, 2932, 3014, 3038, 3065, 3084, 3123], '2.5%': [2600], 'glycerol': [2601], '1×': [2603], '(LightShiftTM': [2606], 'chemiluminescent': [2607, 2695], 'kit,': [2609], 'Pierce)': [2610], 'fmol': [2613], 'end-labeled': [2616], 'target': [2617, 2626, 3720], 'extract.': [2624], 'Unlabeled': [2625], '(1': [2628], 'pmol': [2629], 'pmol)': [2632], 'μl': [2635, 2643, 2879, 2956, 2983, 3093, 3119, 3125, 3134], 'added': [2640, 3141], 'per': [2641], 'reaction.': [2646], 'Reaction': [2647], 'loaded': [2650], 'onto': [2651, 2789], 'native': [2652], 'polyacrylamide': [2654], 'pre-electrophoresed': [2656], '30': [2658, 2744], '0.5×': [2661], 'Tris': [2662], 'borate/EDTA,': [2663], 'electrophoresed': [2665], '100': [2667], 'V': [2668], 'being': [2670], 'transferred': [2671], 'positively': [2673], 'charged': [2674], 'nylon': [2675], 'membranes': [2676, 3265], '(HybondTM-N+).': [2677], 'Transferred': [2678], 'DNAs': [2679], 'cross-linked': [2681], 'membrane': [2684], '120': [2686], 'mJ/cm2': [2687], 'detected': [2689, 3174], 'horseradish': [2691], 'peroxidase-conjugated': [2692], 'streptavidin': [2693], '(LightShift™': [2694], 'kit)': [2697], 'Either': [2703], 'MEFs,': [2707], 'GST-Atox1,': [2709], 'GST': [2711], 'alone': [2712], 'biotinylated': [2716, 4133], 'fragment': [2720, 4137], 'BCS.': [2727], 'Identification': [2728], 'bound': [2733], 'probe': [2736], 'preincubating': [2740], 'specific': [2747, 3458, 3856, 4119, 4265], 'preimmune': [2752, 4270], 'serum.': [2754], 'Competition': [2755], '50-': [2762], '100-fold': [2764, 4200], 'molar': [2765, 4160, 4201], 'excess': [2766, 4161, 4202], 'unlabeled': [2769, 4163, 4204, 4208], 'fragments': [2773, 3155, 4148], 'mutated': [2775], 'fragments.': [2777], 'Chromatin': [2778], 'Immunoprecipitation': [2779], 'Assay': [2780], '(ChIP)—Identical': [2781], 'adhere': [2788], 'tissue': [2790], 'plates': [2792], 'medium.': [2795], '18': [2797], 'h,': [2798], 'CuCl2.': [2812, 3210], 'following': [2818, 3178], 'Upstate': [2820], 'Biotechnology': [2821], 'treated': [2828], 'formaldehyde': [2830, 3115], '(final': [2831], 'concentration': [2832, 3238], '1%)': [2834], '15': [2836], 'cross-link': [2842], 'harvesting.': [2847], 'Then': [2848, 3071, 3117], 'twice': [2852, 3075], 'ice-cold': [2854], 'PBS': [2855], 'protease': [2857, 2894], 'inhibitor,': [2858], 'scraped': [2859], 'conical': [2861], 'tubes,': [2862], 'pelleted': [2864], '4': [2866, 2872, 2949, 2994, 3124, 4296], '2000': [2869], 'rpm': [2870], '°C.': [2873, 2995, 3153], 'resuspended': [2876], '150': [2878, 3020], 'lysis': [2881], '(1%': [2883], 'SDS,': [2884, 2926, 3008, 3032], 'Tris,': [2890, 3068], 'pH': [2891, 2936, 3018, 3042, 3069, 3085, 3130], '8.1,': [2892, 2937, 3019, 3043], 'inhibitor)': [2895], 'ice.': [2902, 2914], 'Resuspended': [2903], 'sonicated': [2906], 'four': [2907], 'times': [2908, 3090], 's': [2911], 'centrifugation,': [2916], 'supernatant': [2918], '1:10': [2921], 'dilution': [2923], '(0.01%': [2925], '1.1%': [2927], '1.2': [2930], '16.7': [2933], 'Tris-HCl,': [2935, 3017, 3041, 3081, 3129], '167': [2938], 'NaCl).': [2940], 'lysate': [2943], 'precleared': [2945], 'salmon': [2958, 2985], 'sperm': [2959, 2986], 'DNA/protein': [2960, 2987], 'A-agarose': [2961, 2988], 'beads.': [2962], 'cleared': [2964], 'lysates': [2965], 'anti-Atox1': [2969, 3261], 'IgG': [2974], 'overnight.': [2975], 'Immunoprecipitated': [2976], 'complexes': [2977, 4121, 4196], 'collected': [2979], 'adding': [2981], 'beads': [2989], 'Immunoprecipitates': [2996], 'washed': [2998, 3074], 'once': [2999, 3023, 3048], 'low': [3001], 'salt': [3002, 3026], 'immune': [3003, 3027, 3051], 'complex': [3004, 3028, 3052, 4154], 'wash': [3005, 3029, 3053], '(0.1%': [3007, 3031], 'NaCl),': [3022, 3046], 'high': [3025], '500': [3044], 'LiCl': [3050], '(250': [3055], 'LiCl,': [3057], 'IGEPAL-CA630,': [3059], 'deoxycholic': [3061], 'acid,': [3062], '8.1).': [3070], 'immunoprecipitates': [3072, 3172], 'TE': [3077], '(10': [3079], '8.0)': [3086], 'extracted': [3088], 'SDS': [3096], '0.1': [3098], 'm': [3099, 3122, 3128], 'NaHCO3.': [3100], 'Eluates': [3101], 'pooled': [3103], 'heated': [3105], '6': [3110, 3136, 4168], 'cross-linking.': [3116], '0.5': [3121], '6.5,': [3131], '0.6': [3133], 'mg/ml': [3137], 'proteinase': [3138], 'K': [3139], 'eluates,': [3144], 'Specific': [3164], 'PCR.': [3176], 'amplify': [3183], '100-bp': [3185], 'promoter:': [3191], '5′-GCTAAATTAGTTCTTGCATT-3′': [3192], '(sense)': [3193], '5′-CACGAGGGCACCCACGGGCG-3′': [3195], '(antisense).': [3196], 'Kinetics': [3197], 'Study': [3198], 'Localization': [3201], 'Atox1—MEFs': [3203], 'first': [3205], 'They': [3211], 'then': [3213, 3230, 3253], '5–60': [3219, 3244], 'switched': [3231], 'cold': [3233], 'same': [3237, 3264], 'min.': [3245], 'non-nuclear': [3250, 3273], 'fractions': [3251], 'subjected': [3256], 'blotting': [3259], 'antibody.': [3262], 'probed': [3268], 'anti-tubulin': [3270], '(for': [3271, 3278], 'fraction)': [3274, 3281], 'anti-histone': [3276], 'H3': [3277], 'control.': [3285], 'Statistical': [3286], 'Analysis—All': [3287], 'data': [3288], 'mean': [3292], 'Comparisons': [3295], 'made': [3297], 'one-way': [3299], 'variance': [3302], 'Tukey-Kramer': [3306], 'post-hoc': [3307], 'test.': [3308], 'Values': [3309], 'p': [3311, 4337], '<': [3312], 'considered': [3315], 'statistically': [3316], 'significant.': [3317], 'Copper-induced': [3318, 3895], 'Proliferation': [3320, 3657], 'Requires': [3321], 'Atox1—Stimulation': [3322], 'concentrations': [3329, 3570], 'dose-dependent': [3336, 3804, 4004], 'manner': [3337, 3805, 4005], '(Fig.': [3338, 3354, 3386, 3714, 3790, 3814, 3835, 3893, 3910, 4009, 4047, 4072, 4095, 4139, 4165, 4214, 4293, 4310], '1A': [3339], 'supplemental': [3341, 4012], 'Table': [3342], 'S1).': [3343], 'This': [3344, 3512, 4015], 'significantly': [3349, 3690], 'inhibited': [3350], '1A)': [3355], 'siRNA': [3360, 3841, 3901, 3932], 'knockdown': [3361, 3842, 3902, 3933], '(WT)': [3366], '(supplemental': [3368, 3447, 3542, 3848], 'S1A).': [3370], 'Re-expression': [3371], 'WT-human': [3373], 'effect': [3380, 3635, 3866], '1B).': [3387], 'contrast,': [3389, 3913], 'iron,': [3390], 'zinc,': [3391], 'silver': [3393], '(which': [3394], 'electronic': [3397], 'analogue': [3398], 'Cu(I)': [3400], '(26Furst': [3401], 'Hu': [3403], 'Hackett': [3405], 'Hamer': [3407, 3427], '55:': [3411], '705-717Abstract': [3412], '(281)': [3418], '27Winge': [3421], 'D.R.': [3422], 'Nielson': [3423], 'K.B.': [3424], 'Gray': [3425], 'W.R.': [3426], 'D.H.': [3428], '1985;': [3432, 3489], '260:': [3433], '14464-14470Abstract': [3434], 'Scholar))': [3440], 'had': [3441, 3633, 3864, 4064], 'marginal': [3442], 'effects': [3443], 'S2).': [3449], 'activities': [3459], 'enzyme': [3463], 'ceruloplasmin': [3464], '(Cp),': [3465], 'multiple': [3470], 'extrahepatic': [3471], 'liver': [3480], '(28Chu': [3481], 'F.F.': [3482], 'Olden': [3483], 'K.': [3484], 'Biophys.': [3486], 'Commun.': [3488], '126:': [3490], '15-24Crossref': [3491], '(7)': [3494], '29Hellman': [3497], 'N.E.': [3498], 'Annu.': [3501], '22:': [3505], '439-458Crossref': [3506], '(693)': [3509], 'result': [3513], 'suggests': [3514], 'lacking': [3521], 'bypassed': [3523], '(i.e.': [3530], 'delivery': [3532], 'Cp': [3534, 3541], 'ATP7A': [3536], 'protein),': [3537], 'S3).': [3544], 'findings': [3546, 3945], 'indicate': [3547], 'requires': [3552, 4306], 'but': [3554, 3809, 3906, 3994, 4141, 4268], 'it': [3555, 4238], 'activity.': [3561], 'polyethylene': [3564], 'glycol': [3565], '(PEG)-SOD': [3566], 'PEG-catalase': [3568], 'block': [3572], 'factor-': [3574], 'agonist-induced': [3576], 'ROS': [3577], '(30Ushio-Fukai': [3579], 'Tang': [3581], 'Y.': [3582, 3588], 'Dikalov': [3585], 'S.I.': [3586], 'Ma': [3587], 'Fujimoto': [3589], 'Quinn': [3591], 'M.T.': [3592], 'Pagano': [3593], 'P.J.': [3594], 'Johnson': [3595], '91:': [3602], '1160-1167Crossref': [3603], '(425)': [3606], '31Ushio-Fukai': [3609], 'Akers': [3613], '15022-15029Abstract': [3622], '(585)': [3630], '(data': [3640, 3871, 3941, 4149], 'shown),': [3642], 'suggesting': [3643, 4218, 4276], 'reactive': [3645], 'oxygen': [3646], 'species': [3647], 'response.': [3653], 'Stimulates': [3655], 'Increasing': [3659], 'Cyclin': [3660, 3969], 'Expression': [3662], 'Atox1—To': [3664], 'determine': [3665, 3717, 4100, 4236], 'mechanism': [3667, 3959], 'WT': [3688, 3735, 3781, 3807, 3846, 4007, 4039, 4114, 4262], '22': [3699], '3%': [3701], '34': [3703], '4%,': [3705], 'effect,': [3707], 'absent': [3710], '2A).': [3715], 'downstream': [3719], 'genes': [3721], 'progression,': [3728], 'mRNA': [3743, 3797], 'level': [3744], 'D1,': [3747, 3905], 'regulator': [3750], 'G1-S': [3752], 'progression': [3753], '(32Fu': [3754], 'Wang': [3756], 'Li': [3758], 'Z.': [3759], 'Sakamaki': [3760], 'Pestell': [3762], 'R.G.': [3763], 'Endocrinology.': [3764], '145:': [3766], '5439-5447Crossref': [3767], '(817)': [3770], 'dramatically': [3774], 'down-regulated': [3775], 'compared': [3779], 'further': [3785], '2B).': [3791, 3815], 'stimulation': [3821], 'up-regulated': [3822], '2C),': [3836], 'S2B).': [3850], 'because': [3859], 'neither': [3860], 'zinc': [3861], 'nor': [3862], 'any': [3865], 'shown).': [3873, 3943, 4151], 'copper-': [3876], 'did': [3880], 'occur': [3882], 'cyclins': [3885], 'B1': [3892, 3909, 3940], '2C).': [3894], '2D).': [3911], 'By': [3912], 'absence': [3916], 'rate': [3920], 'decreased': [3924], '40%': [3927], 'inducing': [3953], 'dependent': [3960], 'Binds': [3964], 'Activates': [3967], 'Copper-dependent': [3974], 'Manner—We': [3975], 'next': [3976], 'whether': [3978], 'Luciferase': [3987], 'silver,': [3996], '3A': [4010], 'S4A).': [4014], 'abrogated': [4018], 'Atox1-WT.': [4028], 'deletion': [4031, 4058], 'copper-responsive': [4043, 4089], '-585/-495': [4046], '3B,': [4048, 4073, 4096], 'left': [4049], 'panel).': [4050, 4098], 'middle': [4074], 'panel),': [4075], 'Atox1-responsive': [4079], 'resides': [4086], 'within': [4087], 'between': [4091], '-585': [4092], '-495': [4094], 'right': [4097], 'if': [4101, 4237, 4319], 'could': [4104], 'specifically': [4105], 'bind': [4106, 4222], 'region,': [4109], 'EMSAs': [4112], 'DNA-protein-binding': [4120], 'major': [4126, 4194, 4279], 'slower': [4127, 4280], 'migrating': [4128, 4281], 'band': [4129, 4282], 'only': [4130], '3C),': [4140], '-585/-556,': [4144], '-565/-536': [4145], '-525/-496': [4147], 'DNA-protein': [4153, 4195, 4274], 'formation': [4155], 'competed': [4157, 4198], '50-fold': [4159], '3C,': [4166, 4215, 4294, 4311], 'lanes': [4167, 4295, 4312], '7).': [4170], '-545': [4174], '-516': [4176], 'area': [4178], 'greater': [4180], 'detail,': [4181], 'spanned': [4184], 'sequential': [4188], 'substitutions': [4190], 'created.': [4192], 'mutants,': [4205], 'except': [4206], '-535/-530': [4213], 'lane': [4216], '8),': [4217], '-535': [4226, 4246, 4290], '-530': [4228, 4248, 4292], '(5′-GAAAGA-3′)': [4229], 'binds': [4242, 4322], 'promoter,': [4253, 4327], 'supershift': [4256], 'serum,': [4272], 'supershifted': [4273], 'complexes,': [4275], '5).': [4298], 'Note': [4299], 'vitro': [4309], '1,': [4313], '2,': [4314], '3).': [4316], 'directly': [4321], 'GST-Atox1.': [4333]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024301095', 'counts_by_year': [{'year': 2024, 'cited_by_count': 31}, {'year': 2023, 'cited_by_count': 24}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-14T02:28:14.068514', 'created_date': '2016-06-24'}
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