Publication Information

{'id': 'https://openalex.org/W2024299558', 'doi': 'https://doi.org/10.1097/00002480-198907000-00155', 'title': 'A Novel Approach to Anticoagulation Control', 'display_name': 'A Novel Approach to Anticoagulation Control', 'publication_year': 1989, 'publication_date': '1989-07-01', 'ids': {'openalex': 'https://openalex.org/W2024299558', 'doi': 'https://doi.org/10.1097/00002480-198907000-00155', 'mag': '2024299558', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2597555'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00002480-198907000-00155', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187010', 'display_name': 'ASAIO Transactions', 'issn_l': '0889-7190', 'issn': ['0889-7190', '2375-0952'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102899682', 'display_name': 'Jae‐Seung Kim', 'orcid': 'https://orcid.org/0000-0003-3052-6444'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JAE-SEUNG KIM', 'raw_affiliation_strings': ['College of Pharmacy, University of Michigan, Ann Arbor 48109-1065'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, University of Michigan, Ann Arbor 48109-1065', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045351622', 'display_name': 'Christopher K. Vincent', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'CHRISTOPHER VINCENT', 'raw_affiliation_strings': ['(University of Michigan)'], 'affiliations': [{'raw_affiliation_string': '(University of Michigan)', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084369211', 'display_name': 'Ching‐Leou Teng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'CHING-LEOU C. TENG', 'raw_affiliation_strings': ['(University of Michigan)'], 'affiliations': [{'raw_affiliation_string': '(University of Michigan)', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075997575', 'display_name': 'Thomas W. Wakefield', 'orcid': 'https://orcid.org/0000-0001-7362-2634'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'THOMAS W. WAKEFIELD', 'raw_affiliation_strings': ['Samuel and Jean Frankel Cardiovascular Center'], 'affiliations': [{'raw_affiliation_string': 'Samuel and Jean Frankel Cardiovascular Center', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051865218', 'display_name': 'Victor C. Yang', 'orcid': 'https://orcid.org/0000-0003-0971-5996'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'VICTOR C. YANG', 'raw_affiliation_strings': ['Pharmaceutical Sciences'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Sciences', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.109, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.767056, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '35', 'issue': '3', 'first_page': '644', 'last_page': '646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12352', 'display_name': 'Heparin-Induced Thrombocytopenia and Thrombosis', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12352', 'display_name': 'Heparin-Induced Thrombocytopenia and Thrombosis', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10065', 'display_name': 'Atrial Fibrillation Management and Outcomes', 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protamine-sulfate', 'display_name': 'Protamine sulfate', 'score': 0.53639925}, {'id': 'https://openalex.org/keywords/extracorporeal', 'display_name': 'Extracorporeal', 'score': 0.5102725}], 'concepts': [{'id': 'https://openalex.org/C2780835560', 'wikidata': 'https://www.wikidata.org/wiki/Q5449573', 'display_name': 'Protamine', 'level': 3, 'score': 0.97097564}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.8635652}, {'id': 'https://openalex.org/C2779354726', 'wikidata': 'https://www.wikidata.org/wiki/Q22075855', 'display_name': 'Protamine sulfate', 'level': 4, 'score': 0.53639925}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5241371}, {'id': 'https://openalex.org/C2779915274', 'wikidata': 'https://www.wikidata.org/wiki/Q1115882', 'display_name': 'Extracorporeal', 'level': 2, 'score': 0.5102725}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.45289627}, {'id': 'https://openalex.org/C2778205648', 'wikidata': 'https://www.wikidata.org/wiki/Q215118', 'display_name': 'Anticoagulant', 'level': 2, 'score': 0.44352064}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.41979614}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.38613236}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35877508}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34915924}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20372301}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.071338624}], 'mesh': [{'descriptor_ui': 'D005112', 'descriptor_name': 'Extracorporeal Circulation', 'qualifier_ui': 'Q000295', 'qualifier_name': 'instrumentation', 'is_major_topic': True}, {'descriptor_ui': 'D006440', 'descriptor_name': 'Hemofiltration', 'qualifier_ui': 'Q000295', 'qualifier_name': 'instrumentation', 'is_major_topic': True}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005112', 'descriptor_name': 'Extracorporeal Circulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006440', 'descriptor_name': 'Hemofiltration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007688', 'descriptor_name': 'Kidneys, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008567', 'descriptor_name': 'Membranes, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010976', 'descriptor_name': 'Platelet Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010976', 'descriptor_name': 'Platelet Count', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00002480-198907000-00155', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187010', 'display_name': 'ASAIO Transactions', 'issn_l': '0889-7190', 'issn': ['0889-7190', '2375-0952'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2597555', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4237384329', 'https://openalex.org/W336970865', 'https://openalex.org/W2327743808', 'https://openalex.org/W2111990318', 'https://openalex.org/W2049849989', 'https://openalex.org/W2030437901', 'https://openalex.org/W2024299558', 'https://openalex.org/W1996566534', 'https://openalex.org/W1994434805', 'https://openalex.org/W198317567'], 'abstract_inverted_index': {'Heparin': [0], 'used': [1, 11], 'in': [2], 'extracorporeal': [3], 'therapy': [4], 'often': [5], 'leads': [6], 'to': [7], 'bleeding': [8], 'complications.': [9], 'Protamine': [10], 'for': [12], 'heparin': [13], 'reversal': [14], 'can': [15], 'cause': [16], 'adverse': [17], 'hemodynamic': [18, 68], 'responses.': [19], 'To': [20], 'control': [21], 'both': [22, 78], 'types': [23], 'of': [24, 56, 60, 88, 93, 99], 'complications,': [25], 'a': [26, 36], 'cellulosic': [27], 'hollow-fiber': [28], 'filter': [29, 49, 74], 'device': [30], 'containing': [31], 'immobilized': [32, 94], 'protamine': [33, 37, 73, 95], '(defined': [34], 'as': [35], 'filter)': [38], 'was': [39], 'developed.': [40], 'In': [41, 70], 'vivo': [42], 'experiments': [43], 'with': [44, 85], 'dogs': [45], 'showed': [46], 'that': [47], 'the': [48, 57, 72, 79, 86, 91, 100], 'not': [50], 'only': [51], 'removed': [52], 'more': [53], 'than': [54], '80%': [55], 'anticoagulant': [58], 'activity': [59], 'heparin,': [61], 'but': [62], 'also': [63, 75], 'caused': [64], 'no': [65], 'clinically': [66], 'significant': [67], 'response.': [69], 'addition,': [71], 'significantly': [76], 'attenuated': [77], 'thrombocytopenic': [80], 'and': [81], 'granulocytopenic': [82], 'responses': [83], 'associated': [84], 'use': [87, 92], 'protamine.': [89, 106], 'Moreover,': [90], 'considerably': [96], 'reduced': [97], 'activation': [98], 'blood': [101], 'complement': [102], 'system': [103], 'by': [104], 'free': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024299558', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-10T03:03:36.401043', 'created_date': '2016-06-24'}