Publication Information

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2601, 2752, 2883, 3509, 3704], 'various': [728, 1330], 'isoforms': [729], 'important': [734, 953, 1531, 1565], 'when': [740, 1012, 1088, 1119, 1606, 1782, 2199], 'VEGF-B': [741], 'promotes': [742, 2925, 3301, 3418], 'without': [745, 3422, 3466], 'predominant': [747], 'better': [756], 'VEGF-A': [758], 'isoform.32BDNF': [759], 'member': [762], 'neurotrophin': [765], 'family': [766], 'widely': [769], 'many': [773, 921], 'functions': [774], 'extending': [775], 'beyond': [776, 1823], 'effects.33': [779], 'ischemia,': [782, 1260, 1829], 'higher': [783, 1237], 'levels': [784, 1575, 2150], 'BDNF': [786, 794, 806, 841, 869, 879, 1771, 1963, 2149, 2924, 3021, 3552, 3624], 'recovery,34,35': [792], 'whereas': [793], 'knock': [795], 'down': [796], 'worsened': [797, 823], 'outcome.25': [799], 'Mice': [800], 'expressing': [801, 834, 1572], 'mutant': [803, 835], 'variant': [804, 3622], '(Met': [807], 'BDNF)': [808], 'had': [809, 1098], 'worse': [811], 'comparison': [814], 'wild-type': [816], 'mice': [817, 1089, 1854], 'attributed': [826, 1193], 'impaired': [829], 'animals': [833, 2160], 'BDNF.36': [836], 'unique': [838], 'aspect': [839], 'biology': [842], 'identification': [845], 'involvement': [848, 1509], 'crosstalk': [851], 'constituents': [854], 'central': [863], 'nervous': [864], 'system': [865], 'insults.20,37': [867], 'Additionally,': [868], 'reported': [872, 2122], 'regulate': [874], 'VEGF.33,38': [878], 'cardiovascular': [884], 'development33': [885], 'found': [887, 1601, 1748], 'induce': [889, 943, 1199], 'robust': [891, 1055], 'comparable': [897], 'VEGF.20Nonpharmacologic': [901], 'That': [903, 1166], 'Improve': [904, 1167], 'Recovery:': [905], 'Effect': [906, 2981], 'AngiogenesisExercise/Physical': [908], 'TherapyIt': [909], 'exercise': [913, 976], 'preconditioning': [914, 3725], 'induces': [915, 2784, 2887, 3699], 'tolerance': [916], 'proposed': [922], 'stimulation': [929, 982, 1035, 1087, 2052, 3785, 3814], 'neurogenesis.39': [933], 'Physical': [934, 3751], 'activity': [935, 3381, 3752], 'also': [939], 'shown': [941, 1111, 1172, 1264, 1358, 1416, 1508, 1809, 1976, 2025], 'as': [949, 1291, 1702, 2336, 2362, 2708], 'well.40': [950], 'finding': [954], 'study,': [957, 1842], 'inhibition': [961, 2179], 'nitric': [964, 3759], 'oxide': [965, 3760], 'synthase': [966], 'or': [967, 1370, 1719, 2178], '(with': [969], 'endostatin)': [970], 'abolished': [971, 1069], 'beneficial': [973, 2325], 'outcome.40Peripheral/Transcranial': [978], 'Magnetic': [979], 'StimulationNoninvasive': [980], 'used': [985], 'extensively': [986], 'rehabilitation': [988], 'research': [989, 1218], 'promise': [992], 'promoting': [994], 'reviewed': [1001], 'recently.41': [1002], 'mechanism': [1004], 'persistent': [1007], 'benefit': [1008, 1725], 'intervention,': [1011], 'combined': [1013], 'physical': [1015], 'therapy,': [1016], 'not': [1018, 1899, 2005], 'entirely': [1019], 'understood.': [1020], 'study': [1024, 3937], 'middle': [1026, 1397, 3567], 'artery': [1028, 1399, 2857, 3569], 'occlusion': [1029, 1400, 3570], 'rat': [1032, 1384, 3475, 3566, 3989], 'model,': [1033], 'electric': [1034], 'resulted': [1036, 1401], 'apoptosis': [1039], 'inflammation': [1041, 1274], 'cortex42': [1048], 'accompanied': [1052], 'factors,': [1059, 1676], 'antiapoptotic': [1066], 'inhibiting': [1071], 'Akt': [1072, 4098], 'activation.42': [1073], 'importance': [1075], 'further': [1079, 2347], 'positive': [1083], 'peripheral': [1086, 3858], 'treated': [1090, 1347, 1622, 1714], 'specific': [1093], 'inhibitor': [1094], 'receptor-2': [1097], 'toward': [1102], 'injured': [1104], 'area.43Low-Level': [1105], 'Laser': [1106, 1150], 'TherapyLight': [1107], 'therapy': [1108, 1151, 2192, 2503, 3893, 3924, 3963, 3995, 4028], 'reduce': [1113, 3561], 'infarct': [1114, 3562], 'size': [1115, 3563], 'administered': [1120, 1822, 1844, 1935], 'at': [1121, 1431, 1443, 1608, 1644, 1728, 1777, 2218], 'least': [1122], '6': [1123, 1798], 'onset.44,45': [1128], 'Experts': [1129], 'technique': [1132], 'agreed': [1134], 'critical': [1137], 'role': [1138, 2637, 2668, 2755, 3853], 'protection': [1145, 3501], 'afforded': [1146], 'light': [1148, 3923, 3962], 'therapy.46,47': [1149], 'currently': [1153], 'clinical': [1155, 1324, 1707], 'trials': [1156, 1325, 1774], 'promotion': [1158], 'stroke.48Repurposed': [1163], 'Pharmacological': [1164], 'RecoveryStatinsStatins': [1169], 'limit': [1174], 'insult': [1177], 'ischemia.15,49': [1186], 'observed': [1188], "statins'": [1196], 'ability': [1197], 'neuroprotection,': [1201, 3266], 'neuroplasticity,': [1202], 'zone.14,15': [1209], 'Data': [1210], 'from': [1211, 1922, 1972, 2411, 2456], 'vitro': [1213, 3096], 'ex': [1215], 'vivo': [1216], 'support': [1219, 1473], 'biphasic': [1221], 'dose-dependent': [1222], 'statins': [1225, 1256, 1261, 1281], 'lower': [1230], 'concentrations': [1231, 1239], 'statin': [1238], 'produce': [1240], 'antiangiogenic': [1242, 1268, 2191], 'cells.14,15': [1246], 'striking': [1249], 'contrast': [1250], 'cancer50': [1272], 'settings.51,52': [1275], 'concluded': [1279, 1651], 'dose-': [1284], 'context-dependent': [1286], 'modulatory': [1287], 'previously': [1294, 1913], 'reviewed.53Angiotensin': [1295], 'II': [1296, 1311, 1351], 'Receptor': [1297], 'Type': [1298, 1313, 1353, 1548, 1555, 1578, 1585, 2141], 'AntagonistsSimilar': [1300], 'statins,': [1303], 'angiotensin': [1310, 1350, 3503], 'receptor': [1312, 1352, 1992, 3469, 3504], 'antagonists': [1315, 1355], 'conflicting.': [1320], 'meta-analysis': [1322], 'using': [1326, 3938], 'these': [1327, 1937, 2158], 'agents': [1328], 'disease': [1331], 'states': [1332], 'pointed': [1333], 'small,': [1336], 'but': [1337, 1691, 1731, 2231, 2253], 'significant,': [1338], 'incidence': [1342], 'lung': [1344], 'cancer': [1345], 'patients.54': [1348], 'pro-': [1362], 'antiangiogenic,': [1364], 'depending': [1365], 'situation': [1368], '(ischemia': [1369], 'not)': [1371], 'involved.55': [1374], 'set': [1378, 1925], 'experiments': [1380, 1927], 'done': [1381], 'model': [1385, 2139], 'treatment': [1389, 1413, 1435, 1727, 1910, 2886, 4034], 'candesartan': [1391], '3': [1393, 1845], 'temporary': [1396], 'outcomes': [1406], 'state.56': [1410], 'This': [1411], 'acute': [1412, 3967, 4071], 'subsequently': [1415], 'associated': [1419, 1763, 1857, 2208, 2788, 3377, 3997], 'nonischemic': [1429, 1880, 2360], 'hemispheres': [1430, 1442, 3512], '24': [1432, 1609, 1826], 'density': [1439, 2553], '7': [1444], 'days.32': [1445], 'Most': [1446], 'believe': [1447], 'occurs': [1451, 2243, 2280], 'ipsilateral': [1454], 'hemisphere': [1455, 1513, 1529, 1881, 2361], 'stroke57': [1457], 'compare': [1461], 'cortical': [1464, 3131], '2': [1468, 1660, 1964, 2142], 'sides': [1469], 'claim.': [1475], 'well': [1478, 2225], 'known,': [1479], 'result': [1488, 2088, 2320], 'diaschisis': [1490], '(distant': [1491], 'areas': [1492, 2030], 'flow': [1495], 'metabolism)58': [1497], 'MRI': [1500], 'victims': [1505], 'consistently': [1507], 'contralesional': [1512, 1528, 1867, 2317], 'recovery.59': [1515], 'possible': [1518], 'striatum': [1525], 'improving': [1539], 'recruitment': [1540, 1994], 'neuroblasts': [1542, 2017], 'recovery.Phosphodiesterase': [1547], '5': [1549, 1556], 'InhibitorsRecent': [1550], 'shows': [1552], 'phosphodiesterase': [1554, 1577, 1584], 'varies': [1558], 'among': [1559], 'determinant': [1566], 'potential,60': [1569], 'endothelium': [1571], 'lowest': [1574], '5being': [1579], 'angiogenic.': [1582], '5inhibitors,': [1586], 'sildenafil': [1587, 1624], 'tadalafil,': [1589], 'rodent': [1595], 'initiated': [1607], 'ischemia61,62': [1615], 'Sensitive': [1616], 'imaging': [1617], 'techniques': [1618], 'revealed': [1619], 'rodents': [1621], 'embolic': [1626, 3929], 'experienced': [1628], 'axonal': [1632, 1668, 1868], 'remodeling': [1633, 1669, 1860, 2125, 2174, 2229], 'compared': [1639], 'saline-treated': [1641], 'controls': [1642], 'beginning': [1643], 'week': [1646], 'injury.63': [1648], 'authors': [1650], 'temporal': [1654, 1892], 'spatial': [1656], 'colocalization': [1657, 1893], 'processes': [1661], 'supported': [1662], 'notion': [1664], 'promoted': [1667], 'therefore,': [1671], 'recovery.Growth': [1672], 'Factor': [1673], 'TreatmentMany': [1674], 'erythropoietin': [1682], '(EPO),': [1683], 'their': [1688, 1700], 'neuroregenerative': [1689], 'effects64': [1690], 'dose-limiting': [1692], 'toxicity': [1693], 'drug': [1695, 2454], 'delivery': [1696, 3943], 'barriers': [1697], 'tempered': [1699], 'therapies.65': [1704], 'small': [1706], 'trial': [1708], '328': [1710], 'placebo': [1720], 'failed': [1721], 'show': [1723], '90': [1729], 'underpowered': [1736], 'do': [1738], 'so.66': [1739], 'EPO': [1740, 1796, 1811, 1834, 1843], 'enhance': [1750], 'angiogenesis,': [1751], 'rats': [1759, 3028, 3828, 3897], 'expression.67': [1772], 'EPO,': [1776], 'first': [1778, 1825], 'promising,': [1779], 'discontinued': [1781], 'mortality': [1786], 'receiving': [1792], 'combination': [1794, 4103], '(within': [1797], 'onset)': [1801], 'tissue-type': [1803], 'plasminogen': [1804], 'activator.68': [1805], 'Subsequently': [1806], 'increases': [1812, 2986], 'matrix': [1813, 2181], 'metalloproteases,': [1814], 'explained': [1818], 'interaction.69': [1820], 'data': [1832], 'continue': [1835], 'encouraging.': [1838], 'focal': [1848, 3154, 3240, 3271], 'affected': [1853], 'sprouting.70': [1869], 'exciting': [1884], 'future': [1887, 2405], 'study.Which': [1888], 'Came': [1889], 'First?Spatial': [1890], 'does': [1898], 'prove': [1900], 'necessary': [1904, 2007], 'mentioned': [1914], 'interventions.': [1915], 'best': [1917], 'supporting': [1919], 'causation': [1920], 'comes': [1921], 'classic': [1924], 'female': [1930], 'canary.': [1931], 'testosterone': [1933], 'songbirds,': [1938], 'abrupt': [1940], 'vocal': [1947], 'control': [1948, 2177], 'nucleus': [1949], 'followed': [1957, 2256], 'significant': [1960, 3423], 'later.71': [1966], 'primarily': [1971], 'cells,': [1974], 'significantly': [1978, 3902], 'nucleus.': [1984], 'signaling': [1987, 3832, 3856], 'blocked': [1989], 'inhibitor,': [1993], 'neurons': [1997], 'impaired.71': [1999], 'although': [2002], 'neuroproliferative': [2010], 'ischemia,26': [2013], 'occur': [2027], 'newly': [2032], 'vascularity.72Consequences': [2034], 'Impaired': [2036], 'AngiogenesisAs': [2037], 'commented': [2038], 'review,1': [2042], 'and/or': [2044], 'hypertensive': [2045, 2251], 'develop': [2048], 'dysfunctional': [2049], 'recovering': [2057], 'penumbra': [2058], 'detrimental.': [2065], 'There': [2066], 'strong': [2068], 'hyperglycemia-mediated': [2071], 'oxidative': [2072], 'damage': [2073, 2185, 2198], 'microvascular': [2075, 2247], 'triggers': [2078], 'cascade': [2080], 'causes': [2084], 'excessive': [2085], 'proliferative': [2091], 'retinopathy.73–75': [2092], 'immature': [2094], 'then': [2096], 'break': [2097], 'leak': [2099], 'worsening': [2100], 'damage.33,73,76': [2104], 'hyperglycemia': [2108], 'vasculature,': [2112], 'especially': [2113, 2314], 'event,': [2117], 'less': [2119], 'clear.': [2120], 'We': [2121], 'extensive': [2123], 'arteriogenesis': [2127], 'pial': [2130, 2173], 'Goto-Kakizaki': [2133], 'rats,': [2134, 2252], 'lean': [2136], 'mild': [2138], 'diabetes.51,77': [2143], 'Also,': [2144], 'cerebrovascular': [2145, 2228], 'permeability,': [2146], 'VEGF-A,': [2147], 'model.': [2155, 3478, 3571], 'bleed': [2161], 'into': [2162], 'perform': [2166], 'poorly': [2167], 'neurobehavioral': [2169], 'tests.77': [2170], 'Prevention': [2171], 'glycemic': [2176], 'metalloproteases': [2182], 'reduces': [2183, 3903, 4068], 'improves': [2187, 2989, 3024, 3753, 3925], 'neurological': [2188, 3905], 'outcome.78': [2189], 'successful': [2195], 'reducing': [2197], 'applied': [2200, 3894], 'locally': [2201], 'retina,79': [2204], 'systemic': [2205], 'use': [2206], 'pressure,': [2212], 'perilous': [2214], 'pursuit': [2215], 'risk': [2219, 2849], 'stroke.In': [2221], 'hypertension,': [2222, 2342], 'established': [2226], 'occurs80–83': [2230], 'our': [2232], 'knowledge': [2233], 'how': [2235], 'hypertension': [2236], 'affects': [2237], 'limited.': [2240], 'Increased': [2241], 'mesenteric': [2246], 'network': [2248], 'spontaneously': [2250], 'phase': [2259], 'pruning.84': [2262], 'significance': [2267], 'yet': [2276], 'determined.ConclusionsAngiogenesis': [2279], 'augmented': [2286], 'pharmacological': [2288], 'nonpharmacologic': [2290], 'means.': [2291], 'vessel': [2295, 2552, 3125], 'transient': [2299], 'injury,': [2306], 'association': [2308], 'plasticity,': [2313], 'could': [2319], 'enduring': [2322], 'negatively': [2331], 'impacted': [2332], 'premorbid': [2334], 'disease,': [2335], 'diabetes': [2340], 'requires': [2346], 'investigation.': [2348], 'Progress': [2349], 'limited': [2355], 'reliance': [2357], 'convenient': [2364], 'control,': [2365], 'focus': [2366], 'zone,': [2371], 'failure': [2373], 'assessment': [2377], 'pre-existing': [2379], 'remodeling.': [2381, 2760, 3178], 'Harnessing': [2382], 'restorative': [2384], 'power': [2385], 'entire': [2391], 'face': [2395], 'diseases,': [2398], 'should': [2399], 'high': [2402], 'priority': [2403], 'study.Sources': [2406], 'FundingSupport': [2408], 'received': [2410, 2452], 'RO1-NS063965': [2412], '(S.C.F.),': [2413], 'Veterans': [2414], 'Affairs': [2415], 'Merit': [2416], 'Review': [2417], '(S.C.F.': [2418], 'A.E.),': [2420], 'American': [2421, 2860], 'Heart': [2422], 'Association': [2423], 'Established': [2424], 'Investigator0740002N': [2425], '(A.E.),': [2426, 2428], 'NS054688': [2427], 'Jordan': [2431], 'Science': [2434, 2479], 'Technology': [2436], '(fellowship': [2437], 'A.A.).DisclosuresDr': [2439], 'consultant': [2443], 'Pfizer,': [2445], 'Inc': [2446, 2449], 'Genentech,': [2448], 'donated': [2453], '(candesartan)': [2455], 'Astra-Zeneca.': [2457], 'Illustration': [2458], 'Colby': [2460], 'Polansky.FootnotesCorrespondence': [2461], 'PharmD,': [2466], 'Jowdy': [2467], 'Professor/Assistant': [2468], 'Dean,': [2469], 'Pharmacy,': [2475], 'HM-1200': 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