Title: Molecular pathology of the aging human brain
Abstract: The neuropathological distinction between normal human brain aging and Alzheimer's disease is essentially quantitative. The lesions which occur in each condition are qualitatively the same but are present in much greater density and wider distribution in Alzheimer tissue. Knowledge about the molecular changes preceding neuronal death in Alzheimer's disease may shed light on the mechanisms of neuronal aging in general. Emerging information about the biochemistry of age-linked brain lesions supports a hypothesis of progressive and irreversible accumulation of rigid, insoluble polymers during aging of human brain cells.
Publication Year: 1982
Publication Date: 1982-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 21
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