Title: The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case-control study
Abstract: CancerVolume 69, Issue 8 p. 2052-2054 ArticleFree Access The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. A case-control study Wan-Long Chuang MD, Wan-Long Chuang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorWen-Yu Chang MD, Corresponding Author Wen-Yu Chang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungDepartment of Internal Medicine, Kaohsiung Medical College, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan, Republic of China===Search for more papers by this authorSheng-Nan Lu MD, Sheng-Nan Lu MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorWang-Pin Su MD, Wang-Pin Su MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorZu-Yau Lin MD, Zu-Yau Lin MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorShinn-Cherng Chen MD, Shinn-Cherng Chen MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorMing-Yuh Hsieh MD, Ming-Yuh Hsieh MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorLiang-Yen Wang MD, Liang-Yen Wang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorSan-Lin You MPH, San-Lin You MPH Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorChien-Jen Chen ScD, Chien-Jen Chen ScD Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of ChinaSearch for more papers by this author Wan-Long Chuang MD, Wan-Long Chuang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorWen-Yu Chang MD, Corresponding Author Wen-Yu Chang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungDepartment of Internal Medicine, Kaohsiung Medical College, 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan, Republic of China===Search for more papers by this authorSheng-Nan Lu MD, Sheng-Nan Lu MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorWang-Pin Su MD, Wang-Pin Su MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorZu-Yau Lin MD, Zu-Yau Lin MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorShinn-Cherng Chen MD, Shinn-Cherng Chen MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorMing-Yuh Hsieh MD, Ming-Yuh Hsieh MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorLiang-Yen Wang MD, Liang-Yen Wang MD Department of Internal Medicine, Kaohsiung Medical College, KaohsiungSearch for more papers by this authorSan-Lin You MPH, San-Lin You MPH Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorChien-Jen Chen ScD, Chien-Jen Chen ScD Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of ChinaSearch for more papers by this author First published: 15 April 1992 https://doi.org/10.1002/1097-0142(19920415)69:8<2052::AID-CNCR2820690808>3.0.CO;2-NCitations: 84AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract To investigate the role of hepatitis B (HBV) and C viruses (HCV) in hepatocellular carcinoma (HCC) in an HBV endemic area and elucidate the interaction of these two viruses, a case-control study of 128 patients with HCC and 384 age-matched and sex-matched control subjects was done. The positive rates of hepatitis B surface antigen (HBsAg, 77.3%, 99 of 128) and anti-HCV (19.5%, 25 of 128) in patients with HCC were significantly higher than in control subjects (P < 0.001). Both HBsAg and anti-HCV were important risk factors for HCC (relative risks, 13.96 and 27.12, respectively), and the risk for HCC was elevated significantly to 40.05 (95% confidence interval, 12.57 to 127.6) when HBsAg and anti-HCV were considered simultaneously. These results suggested that HBV and HCV were associated highly with HCC in an HBV endemic area and that these two viruses might contribute independent but synergistic effects to the pathogenesis of HCC. 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