Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2023889580', 'doi': 'https://doi.org/10.7326/0003-4819-157-4-201208210-00019', 'title': 'Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis', 'display_name': 'Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis', 'publication_year': 2012, 'publication_date': '2012-08-21', 'ids': {'openalex': 'https://openalex.org/W2023889580', 'doi': 'https://doi.org/10.7326/0003-4819-157-4-201208210-00019', 'mag': '2023889580', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22910947'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-157-4-201208210-00019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046071415', 'display_name': 'Athanase D. Protogerou', 'orcid': 'https://orcid.org/0000-0002-3825-532X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Athanase D. Protogerou', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038092500', 'display_name': 'Evangelia Zampeli', 'orcid': 'https://orcid.org/0000-0002-3668-4454'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Evangelia Zampeli', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007341235', 'display_name': 'Petros P. Sfikakis', 'orcid': 'https://orcid.org/0000-0001-5484-2930'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Petros P. Sfikakis', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.219013, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '157', 'issue': '4', 'first_page': '299', 'last_page': '299'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus and Antiphospholipid Syndrome', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/therapeutic-targets', 'display_name': 'Therapeutic Targets', 'score': 0.497392}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.96281046}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.7946464}, {'id': 'https://openalex.org/C2778720950', 'wikidata': 'https://www.wikidata.org/wiki/Q424972', 'display_name': 'Prednisone', 'level': 2, 'score': 0.78413653}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.62680054}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5438493}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.4508821}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.4417859}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.35331815}], 'mesh': [{'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011241', 'descriptor_name': 'Prednisone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011241', 'descriptor_name': 'Prednisone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011859', 'descriptor_name': 'Radiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-157-4-201208210-00019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22910947', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.58, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W1972285732', 'https://openalex.org/W2016802653', 'https://openalex.org/W2153049340', 'https://openalex.org/W2155195115', 'https://openalex.org/W2170108033'], 'related_works': ['https://openalex.org/W4283524728', 'https://openalex.org/W4247645528', 'https://openalex.org/W2411121127', 'https://openalex.org/W2396165291', 'https://openalex.org/W2366611537', 'https://openalex.org/W2326789779', 'https://openalex.org/W2314544353', 'https://openalex.org/W2227428044', 'https://openalex.org/W2138243862', 'https://openalex.org/W2106806370'], 'abstract_inverted_index': {'Letters21': [0], 'August': [1, 536, 552, 557], '2012Low-Dose': [2], 'Prednisone': [3, 404, 488, 513], 'Inclusion': [4, 405, 489, 514], 'in': [5, 130, 212, 252, 283, 322, 363, 406, 490, 515], 'a': [6, 115, 150, 288, 323, 332, 407, 491, 516], 'Methotrexate-Based,': [7, 408, 492, 517], 'Tight': [8, 409, 493, 518], 'Control': [9, 410, 494, 519], 'Strategy': [10, 411, 495, 520], 'for': [11, 37, 54, 73, 162, 208, 328, 412, 496, 521], 'Early': [12, 413, 497, 522], 'Rheumatoid': [13, 314, 414, 482, 498, 523], 'ArthritisAthanase': [14], 'D.': [15, 26, 379], 'Protogerou,': [16, 27, 380], 'MD,': [17, 20], 'Evangelia': [18, 43, 382], 'Zampeli,': [19, 44, 383], 'and': [21, 60, 80, 100, 121, 141, 184, 217, 375, 472, 508, 531], 'Petros': [22, 61, 385], 'P.': [23, 62, 386], 'Sfikakis,': [24, 63, 387], 'MDAthanase': [25], 'MDFrom': [28, 45, 64], 'Medical': [29, 46, 65, 390], 'School,': [30, 47, 66, 391], 'University': [31, 48, 67, 392], 'of': [32, 49, 68, 117, 125, 137, 149, 155, 220, 247, 249, 277, 393, 479, 567], 'Athens,': [33, 35, 50, 52, 69, 71, 394, 396], '11527': [34, 51, 70, 395], 'Greece.Search': [36, 53, 72], 'more': [38, 55, 74], 'papers': [39, 56, 75], 'by': [40, 57, 76, 564], 'this': [41, 58, 77], 'author,': [42, 59], 'authorAuthor,': [78], 'Article,': [79, 374], 'Disclosure': [81, 376], 'Informationhttps://doi.org/10.7326/0003-4819-157-4-201208210-00019': [82], 'SectionsAboutFull': [83], 'TextPDF': [84], 'ToolsAdd': [85], 'to': [86, 106, 134, 152], 'favoritesDownload': [87], 'CitationsTrack': [88], 'CitationsPermissions': [89], 'ShareFacebookTwitterLinkedInRedditEmail': [90], 'TO': [91], 'THE': [92], 'EDITOR:Rheumatoid': [93], 'arthritis': [94, 216], 'is': [95], 'associated': [96], 'with': [97, 214, 285], 'increased': [98, 123], 'mortality,': [99], 'most': [101], 'premature': [102], 'deaths': [103], 'are': [104], 'attributable': [105], 'cardiovascular': [107, 127, 209], 'disease': [108, 119, 174, 189, 542], '(1).': [109], 'Both': [110], 'chronic': [111], 'active': [112], 'inflammation,': [113], 'as': [114], 'result': [116], 'inadequate': [118], 'control,': [120], 'the': [122, 135, 146, 169, 480], 'burden': [124], 'traditional': [126], 'risk': [128, 210, 545], 'factors': [129], 'these': [131], 'patients': [132, 213, 284], 'contribute': [133], 'acceleration': [136], 'atherosclerosis': [138, 251, 357], '(1–3).': [139], 'Bakker': [140, 299, 418, 506], 'colleagues': [142], '(4)': [143], 'clearly': [144], 'showed': [145], 'beneficial': [147], 'effect': [148], 'low': [151], 'moderate': [153], 'dose': [154], 'prednisone': [156, 320], '(10': [157], 'mg/d)': [158], 'on': [159, 477], 'tight': [160, 325], 'control': [161, 326], 'RA': [163], 'when': [164], 'incorporated': [165], 'into': [166], 'treatment': [167], 'during': [168], 'first': [170], '2': [171], 'years': [172], 'after': [173], 'onset.': [175], 'Patient': [176], 'age': [177], 'at': [178], 'baseline': [179], 'was': [180], 'about': [181], '53': [182], 'years,': [183], 'none': [185], 'had': [186], 'serious': [187], 'cardiac': [188], '...References1.': [190], 'Peters': [191], 'MJ,': [192], 'Symmons': [193], 'DP,': [194], 'McCarey': [195], 'D,': [196], 'Dijkmans': [197], 'BA,': [198], 'Nicola': [199], 'P,': [200], 'Kvien': [201], 'TK,': [202], 'et': [203, 243, 274, 311], 'al.': [204, 244, 275], 'EULAR': [205], 'evidence-based': [206], 'recommendations': [207], 'management': [211], 'rheumatoid': [215, 253, 286, 330, 364], 'other': [218], 'forms': [219], 'inflammatory': [221], 'arthritis.': [222, 254, 365], 'Ann': [223, 335], 'Rheum': [224], 'Dis.': [225], '2010;69:325-31.': [226], '[PMID:': [227, 258, 295, 339, 369], '19773290]': [228], 'CrossrefMedlineGoogle': [229, 260, 297, 371], 'Scholar2.': [230], 'Giles': [231], 'JT,': [232], 'Post': [233], 'WS,': [234], 'Blumenthal': [235], 'RS,': [236], 'Polak': [237], 'J,': [238, 308], 'Petri': [239], 'M,': [240], 'Gelber': [241], 'AC,': [242], 'Longitudinal': [245], 'predictors': [246], 'progression': [248], 'carotid': [250, 280], 'Arthritis': [255, 291, 315, 366, 415, 483, 499, 524], 'Rheum.': [256, 367], '2011;63:3216-25.': [257], '21965129]': [259], 'Scholar3.': [261], 'Zampeli': [262], 'E,': [263, 310], 'Protogerou': [264], 'A,': [265, 346], 'Stamatelopoulos': [266], 'K,': [267, 269, 273], 'Fragiadaki': [268], 'Katsiari': [270], 'CG,': [271], 'Kyrkou': [272], 'Predictors': [276], 'new': [278], 'atherosclerotic': [279], 'plaque': [281], 'development': [282], 'arthritis:': [287, 331], 'longitudinal': [289], 'study.': [290], 'Res': [292], 'Ther.': [293], '2012;14:R44.': [294], '22390577]': [296], 'Scholar4.': [298], 'MF,': [300], 'Jacobs': [301, 422, 502], 'JW,': [302], 'Welsing': [303, 426], 'PM,': [304], 'Verstappen': [305, 430], 'SM,': [306], 'Tekstra': [307, 433], 'Ton': [309, 436], 'al;': [312], 'Utrecht': [313, 481], 'Cohort': [316, 484], 'Study': [317, 485], 'Group.': [318], 'Low-dose': [319], 'inclusion': [321], 'methotrexate-based,': [324], 'strategy': [327], 'early': [329], 'randomized': [333], 'trial.': [334], 'Intern': [336], 'Med.': [337], '2012;156:329-39.': [338], '22393128]': [340], 'LinkGoogle': [341], 'Scholar5.': [342], 'Evans': [343], 'MR,': [344], 'Escalante': [345], 'Battafarano': [347], 'DF,': [348], 'Freeman': [349], 'GL,': [350], "O'Leary": [351], 'DH,': [352], 'del': [353], 'Rincón': [354], 'I.': [355], 'Carotid': [356], 'predicts': [358], 'incident': [359], 'acute': [360], 'coronary': [361], 'syndromes': [362], '2011;63:1211-20.': [368], '21305526]': [370], 'Scholar': [372], 'Author,': [373], 'InformationAuthors:': [377], 'Athanase': [378], 'MD;': [381, 384], 'MDAffiliations:': [388], 'From': [389], 'Greece.Disclosures:': [397], 'None': [398], 'disclosed.': [399], 'PreviousarticleNextarticle': [400], 'Advertisement': [401], 'FiguresReferencesRelatedDetailsSee': [402], 'AlsoLow-Dose': [403], 'Marije': [416, 504], 'F.': [417, 505], ',': [419, 423, 427, 431, 434, 437, 441, 447, 452, 457, 463, 467, 471, 476, 503, 507, 527, 530], 'Johannes': [420, 473, 500, 509], 'W.G.': [421, 501], 'Paco': [424], 'M.J.': [425], 'Suzanne': [428], 'M.M.': [429], 'Janneke': [432], 'Evelien': [435], 'Monique': [438], 'A.W.': [439], 'Geurts': [440], 'Jacobine': [442], 'H.': [443], 'van': [444, 450, 460], 'der': [445, 461], 'Werf': [446], 'Grietje': [448], 'A.': [449], 'Albada-Kuipers': [451], 'Zalima': [453], 'N.': [454], 'Jahangier-de': [455], 'Veen': [456, 462], 'Maaike': [458], 'J.': [459], 'Catharina': [464], 'M.': [465], 'Verhoef': [466], 'Floris': [468], 'P.J.G.': [469], 'Lafeber': [470], 'W.J.': [474, 510], 'Bijlsma': [475, 511], 'behalf': [478], 'Group*': [486], 'Low-Dose': [487, 512], 'Theodore': [525], 'Pincus': [526], 'Isabel': [528], 'Castrejon': [529], 'Yusuf': [532], 'Yazici': [533], 'Metrics': [534], '21': [535, 551, 556], '2012Volume': [537], '157,': [538], 'Issue': [539, 554], '4Page:': [540], '299-300KeywordsAtherosclerosisCardiovascular': [541], 'riskLipid': [543], 'profilesMedical': [544], 'factorsMortalityObesityRetrospective': [546], 'studiesRheumatoid': [547], 'arthritisSafetySafety': [548], 'studies': [549], 'ePublished:': [550], '2012': [553, 558, 563], 'Published:': [555], 'Copyright': [559], '&': [560], 'PermissionsCopyright': [561], '©': [562], 'American': [565], 'College': [566], 'Physicians.': [568], 'All': [569], 'Rights': [570], 'Reserved.PDF': [571], 'downloadLoading': [572], '...': [573]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023889580', 'counts_by_year': [{'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-09-13T09:36:43.722249', 'created_date': '2016-06-24'}