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'Using': [64], 'bioinformatics': [65], 'computational': [67], 'modeling': [68], 'approaches,': [69], 'detected': [71], 'striking': [72], 'structural': [73], 'similarity': [74], 'between': [75], 'ZU5-UPA': [80, 167], 'domain': [81], 'present': [82], 'in': [83, 100, 140, 146], 'protein': [86], 'PIDD.': [87], 'This': [88], 'allowed': [89], 'us': [90], 'generate': [92], 'three-dimensional': [94], 'model': [95], 'gain': [98], 'insights': [99], 'molecular': [102], 'mechanism': [103, 175], 'cleavage.': [106], 'Site-directed': [107], 'mutagenesis': [108], 'experiments': [109], 'revealed': [110], 'second': [113], 'serine': [114], 'required': [120], 'autoproteolysis.': [125], 'Furthermore,': [126], 'discovered': [128], 'an': [129], 'important': [130], 'function': [131, 156], 'glutamic': [134], 'acid': [135], 'histidine': [137], 'residues,': [138], 'located': [139], 'proximity': [141], 'site': [145], 'regulating': [147, 177], 'autoprocessing': [149], 'efficiency.': [150], 'Altogether,': [151], 'these': [152], 'results': [153], 'identify': [154], 'show': [161], 'domain-containing': [168], 'proteins,': [170], 'thus': [171], 'suggesting': [172], 'novel': [174], 'immune': [179], 'responses.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023706277', 'counts_by_year': [{'year': 2024, 'cited_by_count': 21}, {'year': 2023, 'cited_by_count': 27}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-14T02:32:11.273634', 'created_date': '2016-06-24'}