Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

Name: Work Video:
Duration: 3 min 30 s
Dipak Kumar Raj; Jianbing Mu; Hongying Jiang; Juraj Kabát; S. P. Singh; Matthew Sullivan; Michael P. Fay; Thomas F. McCutchan; Xin‐zhuan Su
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'In': [13, 229, 879, 4284], 'the': [14, 23, 64, 72, 78, 166, 175, 179, 193, 214, 230, 239, 280, 288, 294, 382, 391, 395, 409, 430, 563, 764, 885, 891, 1085, 1255, 1328, 1507, 1517, 1571, 1634, 1791, 1813, 1816, 1921, 1937, 1946, 1951, 1959, 1962, 1971, 2025, 2028, 2131, 2263, 2312, 2316, 2338, 2574, 2629, 2633, 2637, 2657, 2666, 2820, 2831, 2855, 2865, 2896, 2901, 2981, 2988, 3002, 3009, 3106, 3239, 3329, 3367, 3410, 3512, 3522, 3525, 3565, 3676, 3678, 3711, 3726, 3732, 3766, 3773, 3798, 3827, 3870, 3893, 3910, 3926, 3947, 3965, 3988, 4007, 4038, 4042, 4049, 4053, 4058, 4070, 4076, 4099, 4103, 4107, 4131, 4163, 4176, 4179, 4267, 4347, 4350, 4363, 4388, 4405, 4432, 4445, 4455, 4468, 4475, 4482, 4485, 4491, 4531, 4544, 4563, 4567, 4574], 'human': [15, 24, 231, 240, 677, 765, 892, 2163, 3461, 4003], 'malaria': [16, 232, 766, 1932], 'parasite': [17, 138, 167, 203, 233, 354, 383, 419, 767, 904, 1060, 1274, 1510, 1860, 1967, 1972, 1987, 2000, 2011, 2689, 2856, 3027, 3415, 3889, 3981, 4071, 4078, 4094, 4181, 4276, 4407, 4434, 4532], 'Plasmodium': [18, 234, 768], 'falciparum,': [19, 235, 4286], 'a': [20, 85, 88, 118, 190, 236, 301, 304, 334, 406, 488, 544, 888, 1075, 1134, 1234, 1241, 1246, 1258, 1268, 1276, 1503, 1568, 1675, 1965, 2008, 2479, 2527, 2711, 2838, 2955, 2965, 2978, 3135, 3145, 3220, 3276, 3297, 3351, 3401, 3590, 3761, 3974, 3995, 4000, 4062, 4080, 4153, 4156, 4230, 4417, 4429, 4553], 'homolog': [21, 237, 889], 'of': [22, 80, 129, 178, 195, 238, 296, 345, 394, 411, 547, 569, 659, 676, 763, 884, 890, 1050, 1237, 1338, 1509, 1516, 1570, 1636, 1678, 1798, 1812, 1923, 2027, 2133, 2268, 2303, 2315, 2464, 2573, 2590, 2623, 2632, 2636, 2674, 2687, 2752, 2833, 2841, 2867, 2869, 2889, 2935, 2957, 2983, 2992, 3004, 3171, 3183, 3228, 3242, 3357, 3409, 3432, 3436, 3521, 3539, 3544, 3567, 3570, 3581, 3713, 3778, 3797, 3816, 3866, 3892, 3912, 3968, 3991, 4032, 4044, 4048, 4057, 4065, 4083, 4098, 4110, 4118, 4127, 4166, 4178, 4402, 4454, 4470, 4484, 4487, 4494, 4541, 4549, 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[93, 309], 'that': [94, 187, 310, 403, 541, 1252, 1589, 1957, 2005, 3304, 3695, 4105, 4266, 4349, 4481], 'previously': [96, 312, 2350, 3306], 'P.': [102, 318, 708, 1141, 1152, 1260, 1272, 1394, 1438, 1630, 1716, 1765, 1805, 1952, 3314, 4285], 'falciparum': [103, 319, 769, 1142, 1261, 1273, 1439, 1631, 1806, 1953, 2041], 'CQ': [106, 322, 1063, 1080, 1430, 1564, 1801, 1991, 3465], 'QN.': [108, 324], 'Parasites': [109, 325], 'PfMRP': [112, 162, 188, 328, 378, 404, 1671, 1792, 1857, 1924, 1949, 1963, 2006, 2029, 2201, 2326, 3075, 3786, 3887, 3898, 3934, 3956, 3969, 3992, 4009, 4122, 4139], '(W2/MRPΔ)': [113, 329], 'grow': [116, 332, 4410, 4415, 4583], 'parasitemia': [119, 335, 2707, 2943, 2961, 3011, 3335, 4361, 4422, 4443, 4565], 'than': [121, 337, 1419, 4420], '5%': [122, 338, 2162, 2183, 2185, 2700, 4421], 'under': [123, 339, 2300, 2964, 3134, 3492, 4444], 'normal': [124, 340], 'culture': [125, 341, 2934, 4171, 4424, 4545, 4550, 4576], 'conditions,': [126, 342], 'possibly': [127, 209, 343, 425], 'because': [128, 344, 2991, 3935], 'lower': [130, 346, 4461, 4523], 'efficiency': [131, 347, 4462, 4524], 'removing': [133, 349, 4526], 'toxic': [134, 350, 4527], 'metabolites.': [135, 351, 2036], 'The': [136, 184, 352, 400, 761, 1624, 1984, 2123, 2538, 2651, 2671, 2695, 2914, 2995, 3017, 3048, 3066, 3113, 3152, 3167, 3362, 3389, 3495, 3518, 3553, 3664, 3708, 3821, 3907, 4125, 4450, 4516], 'W2/MRPΔ': [137, 353, 3756, 4132, 4164, 4189, 4263, 4268, 4364, 4406, 4456, 4502, 4508, 4568], 'also': [139, 355, 664, 1057, 1521, 1582, 1591, 1988, 3175], 'accumulated': [140, 356, 1989], 'more': [141, 149, 357, 365, 1978, 1990], 'radioactive': [142, 358, 3621], 'glutathione,': [143, 196, 359, 412], 'CQ,': [144, 156, 197, 360, 372, 413, 444, 1341, 2014, 3245, 4297], 'QN': [146, 199, 362, 415, 1432, 1566, 1803, 1993, 3469], 'became': [148, 364, 1977], 'sensitive': [150, 366, 1979], 'multiple': [152, 206, 368, 422, 1184, 1981], 'antimalarial': [153, 207, 369, 423, 1513, 1982, 2032, 3984], 'drugs,': [154, 208, 370, 424, 3985], 'including': [155, 371, 554], 'QN,': [157, 373, 446, 2015, 3197, 3246, 4298], 'artemisinin,': [158, 374], 'piperaquine,': [159, 375], 'primaquine.': [161, 377], 'localized': [164, 380], 'on': [165, 381, 2327, 2472, 3765, 3804, 3901, 3946], 'surface': [168, 384, 3806], 'membrane,': [169, 385], 'within': [170, 386, 3275], 'membrane-bound': [171, 387], 'vesicles,': [172, 388], 'along': [174, 390], 'straight': [176, 392], 'side': [177, 393], 'D-shaped': [180, 396], 'stage': [181, 397, 2938, 4489], 'II': [182, 398], 'gametocytes.': [183, 399], 'results': [185, 401], 'suggest': [186, 402], 'plays': [189, 405, 3973], 'efflux': [194, 410], 'contributes': [201, 417, 1858], 'by': [210, 426, 1674, 2462, 2478, 2679, 3000, 3450, 3564, 3576, 3745, 3993, 4367], 'pumping': [211, 427], 'drugs': [212, 428, 1606, 2018, 2033, 3368, 3978, 4302], 'outside': [213, 429], 'parasite.': [215, 431, 1954], 'Genes': [432], '(ABC)': [436], '2The': [437], 'abbreviations': [438], 'used': [439, 2043, 3274, 3770, 3858, 3923, 4581], 'are:': [440], 'ABC,': [441], 'cassette;': [443], 'chloroquine;': [445], 'quinine;': [447], 'ART,': [448, 3248], 'artemisinin;': [449], 'PQ,': [450], 'piperaquine;': [451], 'PRQ,': [452], 'primaquine;': [453], 'MQ,': [454, 1065, 3198, 3247, 4299], 'mefloquine;': [455], 'CQS,': [456], 'CQ-sensitive;': [457], 'CQR,': [458], 'CQ-resistant;': [459], 'MRP,': [460], 'protein;': [463], 'WT,': [464], 'wild': [465, 1997], 'type;': [466], 'RBC,': [467], 'red': [468, 2984, 4559], 'blood': [469, 2985, 4560], 'cell;': [470], 'PBS,': [471], 'phosphate-buffered': [472], 'saline;': [473], 'AMQ,': [474], 'amodiaquine;': [475], 'PG,': [476, 3249], 'proguanil;': [477], 'ROS,': [478], 'reactive': [479], 'oxygen': [480], 'species;': [481], 'FV,': [482], 'food': [483], 'vacuole.': [484], 'belong': [486], 'supergene': [489], 'family': [490], 'present': [491], 'organisms': [493], 'from': [494, 1344, 1629, 1690, 2311, 2535, 2597, 2628, 2641, 2854, 3206, 3212, 3222, 3238, 3303, 3413, 3515, 3610, 3628, 3789, 3874, 3909, 4069, 4140, 4186, 4272, 4381, 4529, 4543], 'prokaryotes': [495], 'mammals': [497], '(1Dean': [498], 'M.': [499, 524, 601, 683, 789, 827, 1373, 1398, 1486, 1547, 1708, 1737, 1842, 2071, 2438, 2736, 3308, 3316], 'Annilo': [500], 'T.': [501, 1283, 1363, 1476, 1537, 1646, 1832, 2061, 2085, 2354, 2397, 2761], 'Annu.': [502], 'Re.v': [503], 'Genomics': [504], 'Hum.': [505], 'Genet.': [506, 4335], '2005;': [507, 604, 622, 1041, 1780, 1882, 2115, 2427, 2791], '6:': [508, 1313, 2384], '123-142Crossref': [509], 'PubMed': [510, 531, 607, 625, 637, 651, 696, 714, 756, 874, 929, 948, 966, 990, 1028, 1044, 1104, 1118, 1172, 1205, 1228, 1320, 1381, 1405, 1460, 1494, 1555, 1619, 1666, 1729, 1751, 1783, 1850, 1885, 1908, 2079, 2118, 2145, 2243, 2292, 2391, 2430, 2453, 2616, 2724, 2742, 2794, 2813, 3323, 3851, 4026, 4224, 4250, 4322, 4339], 'Scopus': [511, 532, 608, 626, 638, 652, 697, 715, 757, 875, 930, 949, 967, 991, 1029, 1045, 1105, 1119, 1173, 1206, 1229, 1321, 1382, 1406, 1461, 1495, 1556, 1620, 1667, 1730, 1752, 1784, 1851, 1886, 1909, 2080, 2119, 2146, 2244, 2293, 2392, 2431, 2454, 2617, 2725, 2795, 2814, 3324, 3852, 4027, 4225, 4251, 4323, 4340], '(489)': [512], 'Google': [513, 534, 598, 610, 628, 640, 654, 699, 717, 735, 759, 877, 932, 951, 969, 993, 1031, 1047, 1107, 1121, 1175, 1208, 1231, 1323, 1384, 1408, 1463, 1497, 1558, 1622, 1669, 1732, 1754, 1786, 1853, 1888, 1911, 2082, 2121, 2148, 2246, 2295, 2394, 2433, 2456, 2619, 2727, 2743, 2797, 2816, 3326, 3854, 4029, 4227, 4253, 4325, 4342], 'Scholar,': [514, 599, 611, 629, 641, 700, 718, 736, 933, 952, 970, 994, 1032, 1108, 1209, 1385, 1464, 1733, 1755, 1889, 2083, 2395, 2434, 2728, 2798, 4326], '2Igarashi': [515], 'Y.': [516, 1160, 1704, 1770, 2800, 4209], 'Aoki': [517], 'K.F.': [518], 'Mamitsuka': [519], 'H.': [520, 643, 740, 1870, 2101, 2413, 2777], 'Kuma': [521], 'K.': [522, 619, 631, 645, 704, 746, 803, 807, 941, 1010, 1158, 2089, 2401, 2765, 4330], 'Kanehisa': [523], 'Mol.': [525, 961, 985, 1039, 1200, 1310, 1376, 1455, 1489, 1550, 1777, 1845, 2074, 2381, 4317], 'Biol.': [526, 1162, 1747], 'Evol.': [527], '2004;': [528, 595, 987, 1020, 1202, 1457, 1663, 3320, 4319], '21:': [529], '2149-2160Crossref': [530], '(26)': [533], 'Scholar).': [535, 655, 760, 878, 1048, 1122, 1176, 1409, 1498, 1623, 1670, 1787, 2122, 2149, 2457, 2620, 2744, 2817, 3327, 3663, 4030, 4254, 4343], 'These': [536, 1499], 'genes': [537, 775, 1185, 1238, 1413, 4389], 'encode': [538], 'transmembrane': [539, 1684], 'proteins': [540, 1345, 1587, 2459, 2523], 'can': [542, 663, 1266, 1333, 1590], 'transport': [543, 1128, 1592, 1927], 'wide': [545], 'variety': [546], 'substrates': [548, 1593], 'across': [549], 'extra-': [550], 'intracellular': [552], 'membranes,': [553], 'metabolic': [555], 'products,': [556], 'lipids,': [557], 'sterols,': [558], 'drugs;': [560], 'changes': [561, 4352, 4368, 4386], 'sequences': [565, 2673, 4375], 'or': [566, 901, 2976, 3084, 3094, 3639, 4534], 'expressional': [567], 'ABC': [570, 661, 778, 1053, 1572, 1576], 'have': [572, 1944, 2047, 4278, 4291], 'been': [573, 896, 1071, 2048, 4279, 4292, 4579], 'linked': [574, 1058], 'alteration': [576], 'stress': [578], 'response,': [579], 'cellular': [580], 'detoxification,': [581], 'various': [583, 1605], 'diseases': [584, 681], 'disorders': [586], '(3Stefkova': [587], 'J.': [588, 727, 738, 823, 829, 831, 976, 1154, 1161, 1191, 1353, 1361, 1446, 1466, 1474, 1527, 1535, 1743, 1822, 1830, 1900, 1904, 2051, 2059, 2087, 2093, 2236, 2285, 2399, 2405, 2719, 2763, 2769, 3844, 4215, 4308], 'Poledne': [589], 'R.': [590, 613, 615, 1002, 1008, 1150, 1902], 'Hubacek': [591], 'J.A.': [592, 805, 1211, 1757], 'Physiol.': [593], 'Res.': [594, 731, 1661], '53:': [596], '235-243PubMed': [597], '4Dean': [600], 'Methods': [602, 620], 'Enzymol.': [603, 621], '400:': [605, 623], '409-429Crossref': [606], '(130)': [609], '5Ernst': [612], 'Klemm': [614], 'Schmitt': [616], 'L.': [617, 725, 1006, 1217, 1367, 1480, 1541, 1836, 1876, 2065, 2095, 2234, 2283, 2407, 2771, 3842], 'Kuchler': [618, 644], '460-484Crossref': [624], '(64)': [627, 2120, 2432, 2796], '6Yazaki': [630], 'FEBS': [632, 646], 'Lett.': [633, 647, 752], '2006;': [634, 648, 753, 1164, 1905, 2240, 2289, 3848], '580:': [635, 649], '1183-1191Crossref': [636], '(288)': [639], '7Jungwirth': [642], '1131-1138Crossref': [650], '(167)': [653], 'Mutations': [656], 'and/or': [657, 1431], 'overexpression': [658], 'lead': [665], 'disease-causing': [670], 'microbes': [671], 'treatment': [674, 2463], 'failure': [675], 'cancer': [678], 'other': [680, 1350, 2017, 2035, 4301], '(8Ouellette': [682], 'Legare': [684], 'D.': [685, 833, 958, 1649, 1895, 2440], 'Papadopoulou': [686], 'B.': [687, 750, 821, 869, 978, 1193, 1299, 1448, 2370, 4310], 'Trends': [688], 'Microbiol.': [689, 962, 986, 1040, 1201, 1377, 1456, 1490, 1551, 1846, 2075, 4318], '1994;': [690, 1115], '2:': [691], '407-411Abstract': [692], 'Full': [693, 926, 1023, 1025, 1167, 1169, 1315, 1317, 2386, 2388], 'Text': [694, 927, 1024, 1026, 1168, 1170, 1316, 1318, 2387, 2389], 'PDF': [695, 928, 1027, 1171, 1319, 2390], '(37)': [698], '9Chakraborti': [701], 'P.K.': [702], 'Bhatt': [703], 'Banerjee': [705], 'S.K.': [706], 'Misra': [707], 'Biosci.': [709], 'Rep.': [710], '1999;': [711, 4221], '19:': [712], '293-300Crossref': [713], '(13)': [716], '10Allen': [719], 'J.D.': [720, 1712], 'Brinkhuis': [721], 'R.F.': [722], 'van': [723, 1647, 1652], 'Deemter': [724], 'Wijnholds': [726], 'Schinkel': [728], 'A.H.': [729, 841, 1097], 'Cancer': [730, 751], '2000;': [732, 945, 963, 1225, 1312, 1402, 2383], '60:': [733], '5761-5766PubMed': [734], '11Cervenak': [737], 'Andrikovics': [739], 'Ozvegy-Laczka': [741], 'C.': [742, 855, 863, 956, 2716], 'Tordai': [743], 'A.': [744, 748, 795, 811, 1000, 1093, 1224, 1297, 1392, 1644, 1874, 1893, 2091, 2114, 2368, 2403, 2426, 2449, 2612, 2767, 2790, 2809, 4022, 4213], 'Nemet': [745], 'Varadi': [747], 'Sarkadi': [749], '234:': [754], '62-72Crossref': [755], '(36)': [758], 'genome': [762], 'contains': [770], 'at': [771, 2179, 2297, 2583, 2705, 3042, 3060, 3078, 3098, 3259, 3270, 3287, 3369, 3421, 3477, 3486, 3557, 4359], 'least': [772, 3422, 3746], '15': [773, 3038, 3046], 'predicted': [774, 1683, 3782, 3941], '(12Gardner': [780], 'M.J.': [781, 843], 'Hall': [782], 'N.': [783, 1148, 1612, 3310], 'Fung': [784], 'E.': [785, 1004, 1144, 2600], 'White': [786, 1013], 'O.': [787], 'Berriman': [788], 'Hyman': [790], 'R.W.': [791, 865], 'Carlton': [792], 'J.M.': [793], 'Pain': [794], 'Nelson': [796], 'K.E.': [797], 'Bowman': [798], 'S.': [799, 813, 825, 1012, 1018, 1156, 1223, 1720, 1868, 1872, 1891, 2113, 2226, 2275, 2425, 2436, 2448, 2611, 2789, 2808, 3834, 4021], 'Paulsen': [800], 'I.T.': [801], 'James': [802], 'Eisen': [804], 'Rutherford': [806], 'Salzberg': [808], 'S.L.': [809, 861], 'Craig': [810], 'Kyes': [812], 'Chan': [814], 'M.S.': [815], 'Nene': [816], 'V.': [817, 1897, 2730], 'Shallom': [818], 'S.J.': [819, 915], 'Suh': [820], 'Peterson': [822], 'Angiuoli': [824], 'Pertea': [826], 'Allen': [828], 'Selengut': [830], 'Haft': [832], 'Mather': [834], 'M.W.': [835], 'Vaidya': [836, 2102, 2414, 2778], 'A.B.': [837, 1034, 2103, 2415, 2779], 'Martin': [838], 'D.M.': [839], 'Fairlamb': [840], 'Fraunholz': [842], 'Roos': [844], 'D.S.': [845], 'Ralph': [846], 'S.A.': [847], 'McFadden': [848], 'G.I.': [849], 'Cummings': [850], 'L.M.': [851, 1293, 2364], 'Subramanian': [852, 1364, 1477, 1538, 1833, 2062], 'G.M.': [853], 'Mungall': [854], 'Venter': [856], 'J.C.': [857, 1305, 1371, 1484, 1545, 1840, 2069, 2376, 4217], 'Carucci': [858, 1721, 1771, 4241], 'D.J.': [859, 921, 1722, 1772, 4242], 'Hoffman': [860], 'Newbold': [862], 'Davis': [864], 'Fraser': [866], 'C.M.': [867, 1089], 'Barrell': [868], 'Nature.': [870, 944], '2002;': [871, 1616], '419:': [872], '498-511Crossref': [873], '(3473)': [876], 'particular,': [880], 'mutations': [881, 1253, 1411, 1789, 1814], 'amplification': [883], 'P-glycoprotein': [893], 'has': [895, 1070, 4578], '(CQ),': [908], 'mefloquine': [909], '(MQ),': [910], '(13Foote': [914], 'Thompson': [916], 'J.K.': [917, 1710], 'Cowman': [918, 942, 1111], 'A.F.': [919, 943, 1112], 'Kemp': [920], 'Cell.': [922, 1311, 2382], '1989;': [923, 1101], '57:': [924, 1042], '921-930Abstract': [925], '(516)': [931], '14Reed': [934], 'M.B.': [935], 'Saliba': [936], 'K.J.': [937], 'Caruana': [938], 'S.R.': [939], 'Kirk': [940], '403:': [946], '906-909Crossref': [947], '(722)': [950], '15Duraisingh': [953], 'M.T.': [954, 972, 1187, 1291, 1355, 1387, 1442, 1468, 1529, 1824, 2053, 2362, 4207, 4304], 'Roper': [955], 'Walliker': [957], 'Warhurst': [959, 1399], 'D.C.': [960, 1400], '36:': [964], '955-961Crossref': [965], '(160)': [968], '16Ferdig': [971], 'Cooper': [973, 1188, 1286, 1368, 1443, 1481, 1542, 1837, 2066, 2357, 4305], 'R.A.': [974, 1189, 1287, 1369, 1444, 1482, 1543, 1838, 2067, 2358, 4306], 'Mu': [975, 1190, 1445, 2086, 2398, 2762, 4307], 'Deng': [977, 1192, 1447, 4309], 'Joy': [979, 1194, 1358, 1449, 1471, 1532, 1827, 2056, 2096, 2408, 2772, 4311], 'D.A.': [980, 1038, 1195, 1281, 1359, 1450, 1472, 1533, 1774, 1828, 2057, 2097, 2099, 2352, 2409, 2411, 2603, 2773, 2775, 4013, 4312], 'Su': [981, 1196, 1302, 1374, 1451, 1487, 1548, 1843, 2072, 2106, 2373, 2418, 2782, 4313], 'X.-Z.': [982, 1197, 1375, 1452, 1488, 1549, 1844, 2073, 2107, 2419, 2783, 4205, 4240, 4314, 4328], 'Wellems': [983, 1198, 1308, 1453, 2104, 2379, 2416, 2601, 2604, 2780, 2801, 4014, 4218, 4243, 4315, 4331], 'T.E.': [984, 1199, 1309, 1454, 2105, 2380, 2417, 2605, 2781, 2802, 4015, 4219, 4244, 4316, 4332], '52:': [988, 1203, 1458, 4320], '985-997Crossref': [989, 1204, 1459, 4321], '(208)': [992, 1207, 1462, 4324], '17Price': [995], 'R.N.': [996], 'Uhlemann': [997], 'A.C.': [998], 'Brockman': [999, 1873], 'McGready': [1001], 'Ashley': [1003], 'Phaipun': [1005], 'Patel': [1007], 'Laing': [1009], 'Looareesuwan': [1011], 'N.J.': [1014], 'Nosten': [1015, 1877], 'F.': [1016, 1878, 2224, 2273, 3832], 'Krishna': [1017], 'Lancet.': [1019], '364:': [1021], '438-447Abstract': [1022], '(649)': [1030], '18Sidhu': [1033], 'Valderramos': [1035], 'S.G.': [1036], 'Fidock': [1037, 2098, 2410, 2774], '913-926Crossref': [1043], '(282)': [1046], 'Overexpression': [1049], 'another': [1051], 'transporter': [1054, 1264, 1573, 1948], '(PfMDR2)': [1055], 'but': [1066], 'no': [1067, 4556], 'additional': [1068, 1915], 'evidence': [1069, 2888], 'obtained': [1072, 2203, 2596, 3218, 3237], 'support': [1074], 'for': [1077, 2022, 2248, 2323, 2474, 2519, 2586, 2827, 2864, 2903, 2911, 3037, 3045, 3063, 3081, 3101, 3177, 3372, 3395, 3489, 3615, 3653, 3658, 3675, 3710, 3753, 3757, 3877, 3884, 3933, 4474, 4498, 4507, 4514], 'PfMDR2': [1078, 1124], 'MQ': [1082], 'response': [1083, 1511, 2012], 'since': [1084], 'earliest': [1086], 'descriptions': [1087], '(19Wilson': [1088], 'Serrano': [1090], 'A.E.': [1091, 2228, 2277, 3836], 'Wasley': [1092], 'Bogenschutz': [1094], 'M.P.': [1095], 'Shankar': [1096], 'Wirth': [1098], 'D.F.': [1099], 'Science.': [1100, 1725, 2141, 4220], '244:': [1102], '1184-1186Crossref': [1103], '(396)': [1106], '20Rubio': [1109], 'J.P.': [1110, 2718], 'Exp.': [1113, 4245], 'Parasitol.': [1114, 1779, 2720, 4246], '79:': [1116], '137-147Crossref': [1117], '(49)': [1120], 'Recently,': [1123], 'found': [1126, 1424, 4391, 4480], 'heavy': [1129, 1137], 'metal': [1130, 1138], '(21Rosenberg': [1143], 'Litus': [1145], 'I.': [1146, 1396], 'Schwarzfuchs': [1147], 'Sinay': [1149], 'Schlesinger': [1151], 'Golenser': [1153], 'Baumeister': [1155], 'Lingelbach': [1157], 'Pollack': [1159], 'Chem.': [1163], '281:': [1165], '27039-27045Abstract': [1166], '(29)': [1174], 'Many': [1177], 'resistances': [1179], 'are': [1180, 1581, 3743], 'complex': [1181], 'phenotypes': [1182], 'involving': [1183], '(16Ferdig': [1186, 1441, 4303], '22Dent': [1210], 'Smith': [1212], 'M.M.': [1213], 'Vassilatis': [1214], 'D.K.': [1215], 'Avery': [1216], 'Proc.': [1218, 2108, 2420, 2443, 2606, 2784, 2803, 4016], 'Natl.': [1219, 2109, 2421, 2444, 2607, 2785, 2804, 4017], 'Acad.': [1220, 2110, 2422, 2445, 2608, 2786, 2805, 4018], 'Sci.': [1221, 2111, 2423, 2446, 2609, 2787, 2806, 4019], 'U.': [1222, 2112, 2424, 2447, 2610, 2788, 2807, 4020], '97:': [1226], '2674-2679Crossref': [1227], '(321)': [1230], 'Scholar);': [1232, 1324, 1854], 'limited': [1235], 'number': [1236, 3003], 'usually': [1239], 'key': [1242], 'determining': [1245], 'phenotype.': [1248], 'One': [1249, 1515], 'example': [1250], 'is': [1251, 1567, 1672, 1688, 3715, 3725], '(PfCRT)': [1265], 'convert': [1267], 'clinical': [1269], 'CQ-sensitive': [1270], '(CQS)': [1271], 'into': [1275, 2219, 2262, 2665, 2872, 3826, 4006, 4102], 'CQ-resistant': [1277], '(CQR)': [1278], 'one': [1279, 3013, 3937], '(23Fidock': [1280, 2351], 'Nomura': [1282, 2353], 'Talley': [1284, 2355], 'A.K.': [1285, 2356], 'Dzekunov': [1288, 2359], 'S.M.': [1289, 2360], 'Ferdig': [1290, 1354, 1467, 1528, 1823, 2052, 2361, 4206], 'Ursos': [1292, 2363], 'bir': [1294, 2365], 'Singh': [1295, 2366], 'Sidhu': [1296, 2367], 'Naude': [1298, 2369], 'Deitsch': [1300, 2371], 'K.W.': [1301, 2372], 'X.': [1303, 1357, 1470, 1531, 1826, 2055, 2374], 'Wootton': [1304, 1370, 1483, 1544, 1839, 2068, 2375, 4216], 'Roepe': [1306, 2377], 'P.D.': [1307, 2378], '861-871Abstract': [1314, 2385], '(1163)': [1322, 2393], 'parasites': [1326, 1933, 2042, 2124, 2151, 2696, 2821, 2845, 2897, 2924, 3007, 3330, 3341, 3363, 3430, 3496, 4045, 4119, 4133, 4167, 4473, 4495], 'same': [1329, 4446, 4575], 'mutant': [1330], 'PfCRT': [1331], 'allele': [1332], 'display': [1334], 'very': [1335], 'different': [1336, 1940, 3611], 'suggesting': [1342], 'contribution': [1343], 'such': [1346, 1594], 'as': [1347, 1584, 1595, 1602, 1604, 2692, 2758, 3219, 3814], 'PfPgh-1': [1348, 1420], 'molecules': [1351], '(24Mu': [1352, 1821, 2050], 'Feng': [1356, 1469, 1530, 1825, 2054], 'Duan': [1360, 1473, 1534, 1829, 2058, 2092, 2404, 2768], 'Furuya': [1362, 1475, 1536, 1831, 2060], 'G.': [1365, 1478, 1539, 1834, 2063], 'Aravind': [1366, 1479, 1540, 1835, 2064], 'Xiong': [1372, 1485, 1546, 1841, 2070], '2003;': [1378, 1491, 1552, 1726, 1748, 1847, 2076], '49:': [1379, 1492, 1553, 1848, 1883, 2077], '977-989Crossref': [1380, 1493, 1554, 1849, 2078], '(219)': [1383, 1496, 1557, 1852, 2081], '25Duraisingh': [1386], 'von': [1388], 'Seidlein': [1389], 'L.V.': [1390], 'Jepson': [1391], 'Jones': [1393], 'Sambou': [1395], 'Pinder': [1397], 'Parasitology.': [1401], '121:': [1403], '1-7Crossref': [1404], '(42)': [1407, 4252], 'Indeed,': [1410, 4547], '(other': [1418], 'PfMDR2)': [1422], 'half-maximal': [1433], 'inhibitory': [1434], 'concentration': [1435, 2840, 3682, 3694], '(IC50)': [1436], 'among': [1437, 1939], 'isolates': [1440], '24Mu': [1465, 1526], 'may': [1501], 'modulating': [1506], '(PFA0590w,': [1520], 'called': [1522], 'G2': [1523], 'Ref.': [1525], 'Scholar)': [1559, 1912, 2247, 2296, 3855, 4228], 'member': [1569], 'C': [1574], 'subfamily.': [1575], 'this': [1579, 2045], 'subfamily': [1580], 'known': [1583], '(MRPs)': [1588], 'glutathione': [1596], '(GSH),': [1597], 'glucuronate,': [1598], 'sulfate': [1600], 'conjugates': [1601], 'well': [1603], '(26Rebbeor': [1607], 'J.F.': [1608], 'Connolly': [1609], 'G.C.': [1610], 'Ballatori': [1611], 'Biochim.': [1613], 'Biophys.': [1614, 1660], 'Acta.': [1615], '1559:': [1617], '171-178Crossref': [1618], '(46)': [1621], '(pfmrp)': [1626], 'reported': [1628], 'previously,': [1632], 'expression': [1635, 4129], 'its': [1637, 1996], 'mRNA': [1638], 'investigated': [1642], '(27Klokouzas': [1643], 'Tiffert': [1645], 'Schalkwyk': [1648], 'Wu': [1650], 'C.P.': [1651], 'Veen': [1653], 'H.W.': [1654], 'Barrand': [1655], 'M.A.': [1656], 'Hladky': [1657], 'S.B.': [1658], 'Biochem.': [1659, 1778], 'Commun.': [1662], '321:': [1664], '197-201Crossref': [1665], '(53)': [1668], 'encoded': [1673], 'single': [1676], 'exon': [1677], '5469': [1679], 'bp': [1680, 2627, 4085], '11': [1682], 'α-helix': [1685], 'segments': [1686, 2208, 3794, 3823], 'expressed': [1689], 'early': [1691], 'trophozoite': [1692, 3429], 'late': [1694], 'schizont,': [1695], 'according': [1696, 2129], 'microarray': [1698], 'analyses': [1699], '(28Le': [1700], 'Roch': [1701, 1767], 'K.G.': [1702, 1768], 'Zhou': [1703, 1769], 'Blair': [1705, 1760], 'P.L.': [1706, 1761], 'Grainger': [1707], 'Moch': [1709], 'Haynes': [1711], 'De': [1713], 'La': [1714], 'Vega': [1715, 1764], 'Holder': [1717], 'A.A.': [1718], 'Batalov': [1719], 'Winzeler': [1723, 1775], 'E.A.': [1724, 1776], '301:': [1727], '1503-1508Crossref': [1728], '(1030)': [1731], '29Bozdech': [1734], 'Z.': [1735], 'Llinas': [1736], 'Pulliam': [1738], 'B.L.': [1739], 'Wong': [1740], 'E.D.': [1741], 'Zhu': [1742], 'DeRisi': [1744], 'J.L.': [1745], 'PLoS': [1746], '1:': [1749], 'E5Crossref': [1750], '(1272)': [1753], '30Young': [1756], 'Fivelman': [1758], 'Q.L.': [1759], 'de': [1762], 'la': [1763], 'Le': [1766, 1898], 'Baker': [1773], '143:': [1781], '67-79Crossref': [1782], '(255)': [1785], 'Two': [1788], 'isolates,': [1808], 'good': [1810], 'correlation': [1811], 'whether': [1856, 3971], 'remains': [1863], 'controversial': [1864], '(31Anderson': [1865], 'T.J.': [1866], 'Nair': [1867], 'Qin': [1869], 'Singlam': [1871], 'Paiphun': [1875], 'Antimicrob.': [1879, 3317], 'Agents': [1880, 3318], 'Chemother.': [1881, 3319], '2180-2188Crossref': [1884], '(98)': [1887], '32Cojean': [1890], 'Noel': [1892], 'Garnier': [1894], 'Hubert': [1896], 'Bras': [1899], 'Durand': [1901], 'Malaria': [1903], '5:': [1906], '24Crossref': [1907], '(17)': [1910], 'requires': [1914], 'functional': [1916], 'studies.': [1917], 'To': [1918, 4174, 4344], 'further': [1919], 'investigate': [1920, 3964], 'functions': [1922, 2026, 3967], 'metabolite': [1926], 'resolve': [1936], 'discrepancies': [1938], 'association': [1941], 'We': [1955, 4466], 'showed': [1956, 2004, 4041], 'when': [1958, 3899, 3950], 'CQR': [1966], '(W2)': [1968], 'disrupted,': [1970], 'growth': [1973, 4358, 4452, 4517], 'affected': [1975], 'pfmrp': [1985], 'knock-out': [1986, 4180], 'compared': [1994, 4373], 'type': [1998], '(WT)': [1999], 'W2.': [2001, 4273], 'Our': [2002], 'study': [2003, 2046], 'played': [2007], 'provided': [2020], 'information': [2021], 'better': [2023], 'understanding': [2024], 'transporting': [2031, 3977], 'Parasite': [2037, 2039, 2458, 2682, 2928, 4396], 'Culture-P.': [2040], 'described': [2049, 2349, 2693, 2759, 3305, 4143], '33Furuya': [2084, 2396], 'Hayton': [2088, 2400, 2764, 4329], 'Liu': [2090, 2402, 2766, 4212], 'Nkrumah': [2094, 2406, 2770], 'Fujioka': [2100, 2412, 2776], '102:': [2116, 2428, 2792], '16813-16818Crossref': [2117, 2429, 2793], 'cultured': [2126, 2691, 4439], 'vitro': [2128, 4170], 'methods': [2132], 'Trager': [2134], 'Jensen': [2136, 2139], '(34Trager': [2137], 'W.': [2138], 'J.B.': [2140], '1976;': [2142], '193:': [2143], '673-675Crossref': [2144], '(6219)': [2147], 'Briefly,': [2150, 3328], 'maintained': [2153, 2823], 'RPMI': [2155, 3446], '1640': [2156, 3447], 'medium': [2157, 2192, 2826, 3448, 4425, 4551, 4577], 'containing': [2158, 2755, 3354, 3385, 3524, 3536, 3869, 3999], '25': [2159, 3451, 3568, 3579], 'mm': [2160, 2172, 2490, 2501, 3452], 'HEPES,': [2161], 'O+': [2164], 'erythrocytes': [2165], '(5%': [2166, 2554, 3055], 'hematocrit),': [2167], '0.5%': [2168, 3282], 'Albumax': [2169], '(Invitrogen),': [2170], '24': [2171, 2952], 'sodium': [2173], 'bicarbonate,': [2174], '10': [2176, 2475, 2842, 2958, 4192], 'μg/ml': [2177], 'gentamycin': [2178], '37': [2180, 3370, 3487, 3558], '°C': [2181, 3086, 3261, 3289, 3371, 3488, 3559], 'CO2,': [2184], 'O2,': [2186], '90%': [2188], 'N2': [2189], 'daily': [2191, 2975], 'changes.': [2193], 'Antibody': [2194], 'Production': [2195], 'Western': [2197, 2328, 2565, 3902, 3919, 3948], 'Blotting-Polyclonal': [2198], 'antibodies': [2199, 2534, 2549, 2578, 3096, 3885, 3896, 3908, 4137], 'against': [2200, 2343, 3074, 3780, 3886, 3897, 3955, 4138], 'using': [2204, 2542, 2645, 2699, 2710, 2874, 3144, 3296, 3633, 3669, 3952, 4035, 4136, 4191], 'DNA': [2205, 2207, 2222, 2271, 2625, 2644, 2653, 2672, 2680, 2756, 2852, 2871, 3377, 3783, 3793, 3817, 3822, 4033, 4141, 4185, 4374], 'vaccination.': [2206], 'two': [2210, 3792, 4116, 4262], 'relatively': [2211], 'hydrophilic': [2212], 'peptides': [2213], 'amplified': [2215, 2640, 2652], 'cloned': [2217, 2664, 3825], 'separately': [2218], 'VR2001/MRP': [2220], 'plasmid': [2221, 2270, 2340, 2593, 2870, 3829, 3867, 3996, 4050, 4059, 4100], '(35Oliveira': [2223, 2272, 3831], 'Kamhawi': [2225, 2274, 3833], 'Seitz': [2227, 2276, 3835], 'Pham': [2229, 2278, 3837], 'V.M.': [2230, 2279, 3838], 'Guigal': [2231, 2280, 3839], 'P.M.': [2232, 2281, 3840], 'Fischer': [2233, 2282, 3841], 'Ward': [2235, 2284, 3843], 'Valenzuela': [2237, 2286, 3845], 'J.G.': [2238, 2287, 3846], 'Vaccine.': [2239, 2288, 3847], '24:': [2241, 2290, 3849], '374-390Crossref': [2242, 2291, 3850], '(99)': [2245, 2294, 3853], 'immunization': [2249], '(Fig.': [2250, 2669, 2885, 3819, 3957, 4086, 4145, 4448, 4571], '1A).': [2251, 3820], 'Five-month-old': [2252], 'female': [2253], 'Swiss': [2254], 'Webster': [2255], 'mice': [2256, 3861, 3876, 3894], 'injected': [2258, 2317], 'three': [2259, 3108, 3423, 3864], 'times': [2260, 3109, 3128], 'subcutaneously': [2261], 'tails': [2264], '40': [2266], 'μg': [2267, 2751], 'purified': [2269, 2709], '3-week': [2298], 'intervals': [2299], 'National': [2301, 3240], 'Institutes': [2302, 3241], 'Health': [2304, 3243], 'animal': [2305], 'protocol': [2306], 'LMVR85E.': [2307], 'Blood': [2308, 2947], 'collected': [2310, 2333, 3176, 3881], 'tail': [2313], 'vein': [2314], 'animals,': [2318], 'sera': [2320, 2331, 3873], 'tested': [2322, 2863, 3883, 3900, 3951], 'binding': [2324], 'blot.': [2329], 'Preimmune': [2330], '1': [2334], 'day': [2335, 2979, 4554], 'prior': [2336], 'first': [2339, 4476], 'injection.': [2341], 'Antibodies': [2342, 3779], 'PfMSP-1,': [2344], 'PfCRT,': [2345, 4287, 4377], 'PfMDV-1': [2347], '36Singh': [2435], 'Plassmeyer': [2437], 'Gaur': [2439], 'Miller': [2441], 'L.H.': [2442], '2007;': [2450, 4336], '104:': [2451], '20043-20048Crossref': [2452], '(51)': [2455], 'prepared': [2461, 2950], 'parasitized': [2465], 'RBCs': [2466, 2746, 3601], '0.1%': [2468, 2558, 2942], 'saponin': [2469], 'PBS': [2471, 2481, 3441], 'ice': [2473], 'min': [2476, 3039, 3103, 3397, 3491], 'followed': [2477], 'cold': [2480, 3032], 'wash,': [2482], 'dissolved': [2483, 3253, 3266, 3280], 'SDS': [2485], 'sample': [2486, 2516], 'loading': [2487, 2517], 'buffer': [2488, 2518, 2553, 2582, 3054, 3130, 3384], '(50': [2489], 'Tris-HCl,': [2491], 'pH': [2492], '6.8,': [2493], '2%': [2494, 2945], 'SDS,': [2495], '10%': [2496], 'glycerol,': [2497], '1%': [2498, 3334, 3337, 3460], 'β-mercaptoethanol,': [2499], '12.5': [2500], 'EDTA,': [2502], '0.02%': [2503], 'bromphenol': [2504], 'blue)': [2505], 'separated': [2508], '12%': [2510], 'SDS-PAGE': [2511], 'gels': [2512], 'after': [2513, 2571, 2850, 2860, 2968, 3012, 3104, 3125, 4114, 4400], 'boiling': [2514], '5': [2520], 'min.': [2521, 3047], 'Separated': [2522], 'transferred': [2525], 'Protran': [2528], 'nitrocellulose': [2529], 'membrane': [2530, 2575, 3805], 'probed': [2532], 'immunized': [2536], 'mice.': [2537], 'signals': [2539, 3917], 'developed': [2541], 'horseradish': [2543], 'peroxidase-conjugated': [2544], 'anti-mouse': [2545, 3093], 'IgG': [2546], '(1:3000),': [2547], 'secondary': [2548], 'diluted': [2550, 2940, 3091, 3332, 3340, 3360], 'blocking': [2552, 2581, 3053, 3111], 'nonfat': [2555, 3056], 'milk': [2556, 3057], 'Tween': [2559], '20': [2560], 'PBS),': [2562], 'ECL': [2564], 'blotting': [2566], 'detection': [2567], 'reagents': [2568], '(Amersham': [2569, 3551], 'Biosciences)': [2570], 'incubation': [2572], 'anti-PfMRP': [2577], '(1:1000)': [2579, 3097], 'room': [2584, 3043, 3061, 3079, 3099], 'temperature': [2585, 3044, 3062, 3080, 3100], '2': [2587, 2904, 2912, 3064, 3082], 'h.': [2588, 3065, 3374], 'Construction': [2589], 'Transfection': [2591], 'Vectors-The': [2592], 'pHD22Y': [2594, 2667, 2754], 'Dr.': [2598, 3223], 'Thomas': [2599], '(37Fidock': [2602, 4012], '1997;': [2613, 4023], '94:': [2614, 4024], '10931-10936Crossref': [2615, 4025], '(414)': [2618, 4028], 'A': [2621, 3649, 3748], 'segment': [2622, 4034], '956-bp': [2624], '(132–1068': [2626], '5′': [2630, 4008], 'end': [2631], 'coding': [2634, 3989, 4010, 4108], 'region)': [2635], 'W2': [2642, 2688, 3754, 4187, 4260, 4382, 4435, 4500], 'genomic': [2643], 'PCR': [2646, 2875, 4063, 4081], 'primers': [2647, 4036], '5′-GCACTGCAGGGAGATATTCAAGAACT-3′': [2648], '5′-GCAGCGGCCGCGGACAACCATATAGC-3′.': [2650], 'digested': [2655], 'restriction': [2658], 'enzymes': [2659], 'PstI': [2660], 'NotI': [2662], 'vector': [2668, 3830], '1B).': [2670, 2886], 'all': [2675, 3697, 3925], 'inserts': [2676, 2757], 'confirmed': [2678, 4135], 'sequencing.': [2681], 'Transformation': [2683], 'Selection-Asexual': [2685], 'stages': [2686, 2704], 'above.': [2694], 'synchronized': [2698, 3428], 'd-sorbitol,': [2701], 'schizont': [2703], '8–10%': [2706], 'Percoll-sorbitol': [2712], 'separation': [2713], 'method': [2714, 3301], '(38Lambros': [2715], 'Vanderberg': [2717], '1979;': [2721], '65:': [2722], '418-420Crossref': [2723], '(2855)': [2726], '39Fernandez': [2729], 'Treutiger': [2731], 'C.J.': [2732], 'Nash': [2733], 'G.B.': [2734], 'Wahlgren': [2735], 'Infect.': [2737], 'Immun.': [2738], '1998;': [2739, 4247], '66:': [2740], '2969-2975Crossref': [2741], 'Uninfected': [2745, 3600], 'electroporated': [2748], '200': [2750], 'supercoiled': [2753], '(33Furuya': [2760], '40Wu': [2799], '1996;': [2810], '93:': [2811], '1130-1134Crossref': [2812], '(339)': [2815], 'Following': [2818], 'transformation,': [2819], 'drug-free': [2825], '48': [2828], 'h': [2829, 2953, 3083], 'before': [2830, 2919], 'addition': [2832, 2982, 3566, 4557], 'WR99210': [2834], '(Jacobus': [2835], 'Pharmaceuticals)': [2836], 'final': [2839], 'nm.': [2843], 'Drug-resistant': [2844], 'appeared': [2846, 3929, 4408], '3–4': [2848], 'weeks': [2849, 2859, 2905, 4113], 'transfection.': [2851], 'samples': [2853, 3049], 'cultures': [2857, 2989], '6–8': [2858], 'transfection': [2861], 'presence': [2866, 4043], 'integration': [2868, 2890, 4047, 4097], 'chromosomes': [2873], '(forward': [2876], 'primer': [2877, 2882], 'F': [2878], '5′-GATTGGATAAGACCGTTAATA-3′': [2879], 'reverse': [2881], 'R': [2883, 3640, 3656], '5′-TAAACTTGGTAAAAATTCAAATAG-3′)': [2884], 'When': [2887], 'detected': [2892, 3945], '(see': [2893], 'Fig.': [2894, 4237], '1C),': [2895], 'grown': [2899], 'without': [2900, 2980], 'then': [2907, 3089, 3443], 'selection': [2910], 'weeks.': [2913], 'procedure': [2915], 'done': [2917], 'twice': [2918, 2977, 4552], 'limiting': [2920], 'dilution': [2921, 3417, 4089], 'clone': [2923], 'pfmrp.': [2927], 'Growth': [2929, 4397], 'Invasion': [2931], 'Rate': [2932], 'Assays-A': [2933], 'synchronous': [2936], 'ring': [2937, 4488], 'hematocrit.': [2946], 'smears': [2948], 'every': [2951], 'over': [2954, 4490], 'period': [2956], 'days,': [2959], 'counted': [2963, 4467], 'light': [2966], 'microscope': [2967, 3137], 'Giemsa': [2969], 'staining.': [2970], 'Culture': [2971], 'media': [2972], 'changed': [2974, 4427], 'cells': [2986, 3173, 3185, 4533], 'until': [2987, 3262, 3290], 'crashed': [2990], 'high': [2993, 4360], 'parasitemia.': [2994], 'invasion': [2996, 4477], 'rates': [2997], 'calculated': [2999, 3752], 'dividing': [3001], 'successfully': [3005], 'invaded': [3006, 4472], 'initial': [3010, 4492], 'cycle': [3014, 4478], '(48': [3015], 'h).': [3016], 'experiment': [3018], 'repeated': [3020, 3420], 'four': [3021], 'times.': [3022, 3424], 'Immunofluorescence': [3023], 'Assay-Glass': [3024], 'slides': [3025, 3067, 3107, 3114], 'smear': [3028], 'fixed': [3030], 'methanol': [3033], '(in': [3034], 'dry': [3035], 'ice)': [3036], 'dried': [3041], 'blocked': [3051, 3575], 'PBS)': [3059], 'incubated': [3069, 3365, 3444, 3556], 'mouse': [3071], 'primary': [3072], 'antibody': [3073], '(diluted': [3076], '1:200)': [3077], '4': [3085, 3271, 3670], 'overnight': [3087, 3560], 'goat': [3092], 'anti-rabbit': [3095], '30': [3102, 3396], 'washing': [3105, 3126], 'buffer.': [3112], 'mounted': [3116], 'ProLong': [3118], 'Gold': [3119], 'antifade': [3120], 'reagent': [3121], '4′,6′-diamino-2-phenylindole': [3123], '(Invitrogen)': [3124], 'five': [3127, 3875], 'observed': [3133, 4258, 4351], 'confocal': [3136], '(Leica': [3138], 'SP2,': [3139], 'Leica': [3140], 'Microsystems,': [3141], 'Exton,': [3142], 'PA)': [3143], '100×': [3146], 'oil': [3147, 3501], 'immersion': [3148], 'objective': [3149], 'NA': [3150], '1.4.': [3151], 'images': [3153], 'deconvolved': [3155], 'Huygens': [3157], 'Essential': [3158], 'software': [3159, 3188, 3641], '(version': [3160, 3189, 3642], '3.1;': [3161], 'Scientific': [3162], 'Volume': [3163], 'Imaging': [3164], 'BV,': [3165], 'Hilversum,': [3166], 'Netherlands).': [3168], 'Sequential': [3169], 'Z-sections': [3170], 'stained': [3172, 3381], 'three-dimensional': [3178], 'reconstruction': [3179], 'iso-surface': [3181], 'modeling': [3182], 'representative': [3184], 'Imaris': [3187], '6.0;': [3190], 'Bitplane': [3191], 'AG,': [3192], 'Zurich,': [3193], 'Switzerland).': [3194], 'Drug': [3195, 3292, 3425], 'Assays-CQ,': [3196], 'artemisinin': [3199], '(ART),': [3200], 'primaquine': [3202], '(PRQ)': [3203], 'purchased': [3205], 'Sigma-Aldrich;': [3207], 'amodiaquine': [3208], '(AMQ)': [3209], 'bought': [3211], 'LGC': [3213], 'Promochem;': [3214], 'piperaquine': [3215], '(PQ)': [3216], 'gift': [3221], 'Xinhua': [3224], 'Wang': [3225], '(Guanzhou': [3226], 'University': [3227], 'Traditional': [3229], 'Chinese': [3230], 'Medicine,': [3231], 'China);': [3232], 'proguanil': [3234], '(PG)': [3235], 'pharmacy.': [3244], 'AMQ': [3251], '70%': [3255], 'ethanol': [3256, 3540], 'stored': [3258, 3269, 3286], '-80': [3260, 3288], 'use.': [3263, 3291], 'PRQ': [3264], 'water,': [3268], '°C,': [3272], 'week.': [3277], 'PQ': [3278], 'lactic': [3283], 'acid': [3284], 'assays': [3293], 'performed': [3295, 4091], 'SYBR': [3298, 3386], 'green': [3299, 3387], 'staining': [3300], 'modified': [3302], '(41Smilkstein': [3307], 'Sriwilaijaroen': [3309], 'Kelly': [3311], 'J.X.': [3312], 'Wilairat': [3313], 'Riscoe': [3315], '48:': [3321], '1803-1806Crossref': [3322], '(837)': [3325], 'hematocrit,': [3338, 3618], '(150': [3342], 'μl)': [3343], 'added': [3345], 'wells': [3347], 'triplicate': [3349], '96-well': [3352], 'plate': [3353, 3390], '50': [3355, 3542], 'μl': [3356, 3538, 3543, 3569, 3580], '2-fold': [3358], 'serially': [3359], '72': [3373], 'After': [3375, 3863], 'incubation,': [3376], 'released': [3379], 'lysis': [3383], 'dye.': [3388], 'kept': [3392], 'darkness': [3394], 'read': [3399], 'FLUOstar': [3402], 'Optima': [3403], 'microplate': [3404, 3629], 'reader': [3405, 3630], '(BMG': [3406], 'Labtech).': [3407], 'All': [3408, 3891], 'data': [3411], 'points': [3412], 'each': [3414, 3758, 3878], 'independently': [3419], 'Accumulation': [3426], 'Assay-Highly': [3427], '(parasitemia': [3431], '4–6%': [3433], 'hematocrits': [3435], '5.0%)': [3437], 'washed': [3439], 'supplemented': [3449], 'HEPES': [3453], '(pH': [3454], '7.35),': [3455], '0.2%': [3456, 3458], 'NaHCO3,': [3457], 'd-glucose,': [3459], 'serum,': [3462], 'radioactive-labeled': [3464], '(20': [3466], 'nm': [3467, 3471], '[3-3H]),': [3468], '(2': [3470], '[9-3H]),': [3472], 'reduced': [3474, 4537], 'GSH': [3475], '([glycine-2-3H]': [3476], '1,': [3478], '3,': [3479], '6': [3481], 'nm)': [3482], '(American': [3483], 'Radiolabeled': [3484], 'Chemicals)': [3485], '5–60': [3490], 'continuous': [3493], 'stirring.': [3494], 'centrifuged': [3498], 'through': [3499], 'silicon': [3500], '(Fulka': [3502], 'Chemical': [3503], 'Corp.)': [3504], '(density,': [3505], '1.049)': [3506], '1.5-ml': [3508], 'Eppendorf': [3509], 'tubes,': [3510], 'separating': [3511], 'RBC': [3513, 3687], 'pellet': [3514], 'unincorporated': [3516], 'label.': [3517], 'bottom': [3519], 'tips': [3520], 'tubes': [3523], 'cell': [3526], 'pellets': [3527], 'cut': [3529], 'off': [3530], 'placed': [3532], 'scintillation': [3534, 3592], 'vials': [3535], '100': [3537], '0.5': [3545], 'n': [3546], 'NCS-II': [3547], 'tissue': [3548], 'solubilizer': [3549], 'solution': [3550], 'Biosciences).': [3552], 'lysates': [3554], 'decolorized': [3563], '30%': [3571], 'H2O2.': [3572], 'Luminescence': [3573], 'acidification': [3577], 'glacial': [3582], 'acetic': [3583], 'acid.': [3584], 'Radioactive': [3585], 'measured': [3588], 'liquid': [3591], 'counter': [3593], '(1450': [3594], 'MicroBeta': [3595], 'TriLux;': [3596], 'PerkinElmer': [3597], 'Life': [3598], 'Sciences).': [3599], 'controls': [3603], 'subjected': [3605], 'identical': [3607], 'protocols.': [3608], 'Data': [3609, 3623], 'experiments': [3612], 'normalized': [3614], 'differences': [3616, 4256], 'parasitemia,': [3619], 'labels.': [3622], 'Analysis': [3624], 'Calculation-Data': [3627], 'analyzed': [3632], 'GraphPad': [3634], 'Prism': [3635], '(La': [3636], 'Jolla,': [3637], 'CA)': [3638], '2.7.0)': [3643], '(42R': [3644], 'Development': [3645], 'Core': [3646], 'Team': [3647], 'R:': [3648], 'Language': [3650], 'Environment': [3652], 'Statistical': [3654, 3659], 'Computing.': [3655], 'Foundation': [3657], 'Computing,': [3660], 'Vienna,': [3661], 'Austria2008Google': [3662], 'values': [3666, 3768], 'estimated': [3668, 3744], 'parameter': [3671], 'logistic': [3672], 'models,': [3673], 'where': [3674, 3723], 'computations': [3677], 'control': [3679], '(i.e.': [3680], '=': [3683], '0)': [3684], 'uninfected': [3686], '(acting': [3688], 'like': [3689], 'extremely': [3691], 'large': [3692], 'stops': [3696], 'growth)': [3698], 'set': [3700], '10-20': [3702], 'm': [3703], '1010': [3705], 'm,': [3706], 'respectively.': [3707], 'model': [3709], 'percentage': [3712], 'inhibition': [3714], 'b': [3716, 3734], '+': [3717, 3721], '(100': [3718], '-': [3719], 'b)/[1': [3720], '10(d-X)*H],': [3722], 'X': [3724], 'log': [3727], 'transformed': [3728], 'concentration,': [3730], 'parameters': [3733], '(background': [3735], 'inhibition),': [3736], 'd': [3737], '(logIC50),': [3738], 'H': [3740], '(Hill': [3741], 'coefficient)': [3742], 'squares.': [3747], 'separate': [3749], 'experiment,': [3759], 'paired': [3762], 't': [3763], 'test': [3764], 'log(IC50)': [3767], 'together': [3771], 'confidence': [3775], 'intervals.': [3776], 'Generation': [3777], 'PfMRP-The': [3781], 'sequence': [3784, 4040, 4051], 'downloaded': [3788], 'PlasmoDB,': [3790], 'regions': [3796], 'likely': [3800], 'exposed': [3803], '(hydrophilic)': [3807], 'selected': [3809], '(codons': [3810], '475–705': [3811], '806–1120)': [3813], 'targets': [3815], 'vaccination': [3818, 4142], 'VR2001': [3828], 'immunize': [3860], 'separately.': [3862], 'injections': [3865], 'constructs': [3868], 'target': [3871], 'sequences,': [3872], 'construct': [3879, 4060, 4101], 'lysates.': [3890], 'produced': [3895, 4061], 'blots': [3903], '(data': [3904, 4197, 4392], 'shown).': [3906, 4394], 'region': [3911, 3990, 4011, 4109], 'codon': [3913], '806–1120': [3914], 'gave': [3915], 'stronger': [3916], 'blot': [3920, 3949], 'experiments.': [3927], 'It': [3928], 'specific': [3932], 'only': [3936], 'major': [3938], 'band': [3939], 'molecular': [3942, 4232], 'weight': [3943], 'pooled': [3953], 'antisera': [3954], '1D).': [3958, 4146], 'Genetic': [3959], 'Knock-out': [3960], 'Gene': [3961, 4154], 'Encoding': [3962, 4155], 'PfMRP-To': [3963], 'biological': [3966], 'it': [3972, 4412], 'inserting': [3994], '(pHD22Y)': [3997], 'dihydrofolate': [4004], 'reductase': [4005], 'Amplification': [4031], 'flanking': [4037], 'targeted': [4039], 'transfected': [4054], 'parasites.': [4055], 'Insertion': [4056], 'product': [4064, 4082], '8.68': [4066], 'kilobase': [4067], 'pairs': [4068], 'pfmrp,': [4074], 'whereas': [4075, 4431], 'WT': [4077, 4433], 'had': [4079], '1020': [4084], '1C).': [4087], 'Limiting': [4088], 'identify': [4093], 'clones': [4095, 4117, 4190, 4269], 'chromosome': [4104], 'disrupt': [4106], 'PfMRP.': [4111], 'Five': [4112], 'cloning,': [4115], 'obtained.': [4124], 'absence': [4126], 'above': [4144], 'No': [4147, 4255, 4385], 'Changes': [4148], 'pfcrt,': [4150], 'pfmdr1,': [4151], 'Putative': [4157], 'Sodium': [4158], 'Hydrogen': [4159], 'Exchanger': [4160], '(PfNHE)': [4161], 'Parasite-Cross-contamination': [4165], 'during': [4168], 'occurs': [4172], 'frequently.': [4173], 'identities': [4177], 'clones,': [4182, 4264], 'genotyped': [4184], 'highly': [4193], 'polymorphic': [4194], 'microsatellite': [4195], 'markers': [4196], 'supplemental': [4201], 'Table': [4202], '1)': [4203, 4238], '(43Su': [4204], 'Huang': [4208], 'Huynh': [4210], 'C.Q.': [4211], 'You': [4214], '286:': [4222], '1351-1353Crossref': [4223], '(289)': [4226], 'multicopy': [4231], 'fingerprinting': [4233], 'marker': [4234], 'PfRRM': [4235], '(supplemental': [4236], '(44Su': [4239], '89:': [4248], '262-265Crossref': [4249], 'between': [4259], 'confirming': [4265], 'indeed': [4270], 'derived': [4271], 'Various': [4274], 'resistances.': [4283], 'PfPgh-1,': [4288, 4378], 'PfNHE': [4290, 4380], '45Su': [4327], 'Nat.': [4333], 'Rev.': [4334], '8:': [4337], '497-506Crossref': [4338], '(65)': [4341], 'rule': [4345], 'out': [4346], 'possibility': [4348], 'impaired': [4357, 4451], 'caused': [4366], 'these': [4370], 'genes,': [4371], 'W2/MRPΔ.': [4384], 'Impaired': [4395], 'Vitro': [4399], 'Disruption': [4401], 'PfMRP-': [4403], 'Although': [4404], 'normally,': [4411], 'density': [4418], 'if': [4423], 'once': [4428], 'day,': [4430], 'routinely': [4438, 4580], 'up': [4440], '15%': [4442], 'conditions': [4447], '2A).': [4449, 4572], 'capability': [4453], 'due': [4459, 4521, 4535], 'invading': [4464], 'RBCs.': [4465], 'numbers': [4469, 4486, 4493], 'newly': [4471], 'ratios': [4483], 'similar': [4497], 'both': [4499], '(4.85': [4503], '±': [4504, 4511], '0.40': [4505], 'S.D.': [4506, 4513], 'versus': [4509], '5.27': [4510], '0.51': [4512], 'W2).': [4515], 'impairment': [4518], 'metabolites': [4528], 'inside': [4530], 'ability': [4538], 'acquisition': [4540], 'nutrients': [4542], 'medium.': [4546], 'change': [4548], '(but': [4555], 'cells)': [4561], 'increased': [4562], 'maximum': [4564], '∼7%': [4570], 'Because': [4573], 'variou': [4584]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023639417', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-24T15:23:07.390919', 'created_date': '2016-06-24'}
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