A New Family of Receptor Tyrosine Kinases with a Venus Flytrap Binding Domain in Insects and Other Invertebrates Activated by Aminoacids

Name: Work Video:
Duration: 3 min 30 s
Arnaud Ahier; Philippe Rondard; Nadège Gouignard; N. Khayath; Siluo Huang; Jacques Trolet; Daniel J. Donoghue; Monique Gauthier; Jean‐Philippe Pin; Colette Dissous
{'id': 'https://openalex.org/W2023334359', 'doi': 'https://doi.org/10.1371/journal.pone.0005651', 'title': 'A New Family of Receptor Tyrosine Kinases with a Venus Flytrap Binding Domain in Insects and Other Invertebrates Activated by Aminoacids', 'display_name': 'A New Family of Receptor Tyrosine Kinases with a Venus Flytrap Binding Domain in Insects and Other Invertebrates Activated by Aminoacids', 'publication_year': 2009, 'publication_date': '2009-05-20', 'ids': {'openalex': 'https://openalex.org/W2023334359', 'doi': 'https://doi.org/10.1371/journal.pone.0005651', 'mag': '2023334359', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19461966', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2680970'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0005651', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005651&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005651&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034623205', 'display_name': 'Arnaud Ahier', 'orcid': 'https://orcid.org/0000-0002-9999-3887'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Arnaud Ahier', 'raw_affiliation_strings': ['Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.'], 'affiliations': [{'raw_affiliation_string': 'Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075974351', 'display_name': 'Philippe Rondard', 'orcid': 'https://orcid.org/0000-0003-1134-2738'}, 'institutions': [{'id': 'https://openalex.org/I4210156758', 'display_name': 'Institut de Génomique Fonctionnelle', 'ror': 'https://ror.org/043wmc583', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210156758']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I19894307', 'display_name': 'Université de Montpellier', 'ror': 'https://ror.org/051escj72', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I19894307']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Philippe Rondard', 'raw_affiliation_strings': ['CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France', 'institution_ids': ['https://openalex.org/I4210156758', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042850350', 'display_name': 'Nadège Gouignard', 'orcid': 'https://orcid.org/0000-0001-8787-2503'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nadège Gouignard', 'raw_affiliation_strings': ['Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.'], 'affiliations': [{'raw_affiliation_string': 'Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059342187', 'display_name': 'N. Khayath', 'orcid': 'https://orcid.org/0000-0002-1972-5672'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Naji Khayath', 'raw_affiliation_strings': ['Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.'], 'affiliations': [{'raw_affiliation_string': 'Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032922633', 'display_name': 'Siluo Huang', 'orcid': 'https://orcid.org/0000-0002-8052-4677'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I19894307', 'display_name': 'Université de Montpellier', 'ror': 'https://ror.org/051escj72', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I19894307']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210156758', 'display_name': 'Institut de Génomique Fonctionnelle', 'ror': 'https://ror.org/043wmc583', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210156758']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Siluo Huang', 'raw_affiliation_strings': ['CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210156758']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050091430', 'display_name': 'Jacques Trolet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jacques Trolet', 'raw_affiliation_strings': ['Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.'], 'affiliations': [{'raw_affiliation_string': 'Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I2279609970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087049810', 'display_name': 'Daniel J. Donoghue', 'orcid': 'https://orcid.org/0000-0002-4546-2175'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel J. Donoghue', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry and Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry and Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024573025', 'display_name': 'Monique Gauthier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I134560555', 'display_name': 'Université Toulouse III - Paul Sabatier', 'ror': 'https://ror.org/02v6kpv12', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I134560555']}, {'id': 'https://openalex.org/I4210098684', 'display_name': 'Centre de Recherches sur la Cognition Animale', 'ror': 'https://ror.org/0111s2360', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I134560555', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210098684']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Monique Gauthier', 'raw_affiliation_strings': ['Centre de Recherches sur la Cognition Animale, CNRS, UMR 5169, Université Paul-Sabatier, Toulouse, France'], 'affiliations': [{'raw_affiliation_string': 'Centre de Recherches sur la Cognition Animale, CNRS, UMR 5169, Université Paul-Sabatier, Toulouse, France', 'institution_ids': ['https://openalex.org/I134560555', 'https://openalex.org/I4210098684', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035290703', 'display_name': 'Jean‐Philippe Pin', 'orcid': 'https://orcid.org/0000-0002-1423-345X'}, 'institutions': [{'id': 'https://openalex.org/I4210156758', 'display_name': 'Institut de Génomique Fonctionnelle', 'ror': 'https://ror.org/043wmc583', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210156758']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I19894307', 'display_name': 'Université de Montpellier', 'ror': 'https://ror.org/051escj72', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I19894307']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Philippe Pin', 'raw_affiliation_strings': ['CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR5203, Institut de Génomique Fonctionnelle, Inserm U661, and Université Montpellier 1,2, Montpellier, France', 'institution_ids': ['https://openalex.org/I4210156758', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108031465', 'display_name': 'Colette Dissous', 'orcid': 'https://orcid.org/0000-0002-5003-8205'}, 'institutions': [{'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Colette Dissous', 'raw_affiliation_strings': ['Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.'], 'affiliations': [{'raw_affiliation_string': 'Inserm U547, Université de Lille 2, Institut Pasteur de Lille, Lille, France.', 'institution_ids': ['https://openalex.org/I2279609970', 'https://openalex.org/I154526488']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 2.899, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.825826, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '4', 'issue': '5', 'first_page': 'e5651', 'last_page': 'e5651'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10890', 'display_name': 'Trypanosoma species research and implications', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10890', 'display_name': 'Trypanosoma species research and implications', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11403', 'display_name': 'Invertebrate Immune Response Mechanisms', 'score': 0.9841, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10695', 'display_name': 'Parasites and Host Interactions', 'score': 0.9817, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/receptor-protein-tyrosine-kinases', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'score': 0.47480264}, {'id': 'https://openalex.org/keywords/protein-kinase-domain', 'display_name': 'Protein kinase domain', 'score': 0.4547583}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.80365336}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.7641401}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5151285}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5130045}, {'id': 'https://openalex.org/C2911166042', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'level': 4, 'score': 0.47480264}, {'id': 'https://openalex.org/C32619005', 'wikidata': 'https://www.wikidata.org/wiki/Q24768234', 'display_name': 'Protein kinase domain', 'level': 4, 'score': 0.4547583}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31089765}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.09735763}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07159495}], 'mesh': [{'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007448', 'descriptor_name': 'Invertebrates', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006066', 'descriptor_name': 'Gonads', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006066', 'descriptor_name': 'Gonads', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007313', 'descriptor_name': 'Insecta', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007313', 'descriptor_name': 'Insecta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007448', 'descriptor_name': 'Invertebrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005810', 'descriptor_name': 'Multigene Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010802', 'descriptor_name': 'Phylogeny', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0005651', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005651&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/7e2de76a6d3441b39284800ef9b65439', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2680970', 'pdf_url': 'https://europepmc.org/articles/pmc2680970?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680970', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/A_New_Family_of_Receptor_Tyrosine_Kinases_with_a_Venus_Flytrap_Binding_Domain_in_Insects_and_Other_Invertebrates_Activated_by_Aminoacids/147625', 'pdf_url': 'https://figshare.com/articles/dataset/A_New_Family_of_Receptor_Tyrosine_Kinases_with_a_Venus_Flytrap_Binding_Domain_in_Insects_and_Other_Invertebrates_Activated_by_Aminoacids/147625/1/files/444665.pdf', 'source': {'id': 'https://openalex.org/S4377196282', 'display_name': 'Figshare', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210132348', 'host_organization_name': 'Figshare (United Kingdom)', 'host_organization_lineage': ['https://openalex.org/I4210132348'], 'host_organization_lineage_names': ['Figshare (United Kingdom)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19461966', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0005651', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005651&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.54}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1487554690', 'https://openalex.org/W1580186561', 'https://openalex.org/W1594415132', 'https://openalex.org/W1639582946', 'https://openalex.org/W1845771548', 'https://openalex.org/W1966949090', 'https://openalex.org/W1969214447', 'https://openalex.org/W1974999008', 'https://openalex.org/W1975304761', 'https://openalex.org/W1980823413', 'https://openalex.org/W1995984818', 'https://openalex.org/W2004801897', 'https://openalex.org/W2005913521', 'https://openalex.org/W2012641732', 'https://openalex.org/W2019032222', 'https://openalex.org/W2020257412', 'https://openalex.org/W2023343746', 'https://openalex.org/W2027045807', 'https://openalex.org/W2028415754', 'https://openalex.org/W2029903395', 'https://openalex.org/W2035267273', 'https://openalex.org/W2051697670', 'https://openalex.org/W2059039609', 'https://openalex.org/W2061158065', 'https://openalex.org/W2065283382', 'https://openalex.org/W2069663555', 'https://openalex.org/W2079557731', 'https://openalex.org/W2087847191', 'https://openalex.org/W2089988218', 'https://openalex.org/W2093359457', 'https://openalex.org/W2103174300', 'https://openalex.org/W2105346017', 'https://openalex.org/W2106882534', 'https://openalex.org/W2107277218', 'https://openalex.org/W2110902739', 'https://openalex.org/W2111119053', 'https://openalex.org/W2115476261', 'https://openalex.org/W2117380410', 'https://openalex.org/W2118195172', 'https://openalex.org/W2119575586', 'https://openalex.org/W2122060463', 'https://openalex.org/W2125121305', 'https://openalex.org/W2131544728', 'https://openalex.org/W2140207339', 'https://openalex.org/W2141743775', 'https://openalex.org/W2142495170', 'https://openalex.org/W2147499400', 'https://openalex.org/W2150503843'], 'related_works': ['https://openalex.org/W4392916155', 'https://openalex.org/W3013563583', 'https://openalex.org/W2198509606', 'https://openalex.org/W2126073113', 'https://openalex.org/W2088346679', 'https://openalex.org/W2086259825', 'https://openalex.org/W2075091575', 'https://openalex.org/W2061697147', 'https://openalex.org/W1991624054', 'https://openalex.org/W1989355568'], 'abstract_inverted_index': {'Background': [0], 'Tyrosine': [1], 'kinase': [2, 53], 'receptors': [3, 11, 129], '(RTKs)': [4], 'comprise': [5], 'a': [6, 45, 72, 75, 144, 203], 'large': [7], 'family': [8, 77], 'of': [9, 20, 36, 58, 74, 78, 90, 127, 138, 171, 173, 189, 192, 206, 215, 229], 'membrane': [10], 'that': [12, 57, 68, 114, 126, 137, 143, 156], 'regulate': [13], 'various': [14], 'cellular': [15], 'processes': [16], 'in': [17, 29, 81, 85, 100, 165, 181, 195, 199, 208], 'cell': [18], 'biology': [19], 'diverse': [21], 'organisms.': [22], 'We': [23, 141], 'previously': [24], 'described': [25], 'an': [26, 37, 50], 'atypical': [27], 'RTK': [28], 'the': [30, 59, 120, 131, 168, 174, 227], 'platyhelminth': [31], 'parasite': [32], 'Schistosoma': [33], 'mansoni,': [34], 'composed': [35], 'extracellular': [38], 'Venus': [39, 94], 'flytrap': [40], 'module': [41], '(VFT)': [42], 'linked': [43], 'through': [44], 'single': [46], 'transmembrane': [47], 'domain': [48, 54], 'to': [49, 56, 125, 136, 149], 'intracellular': [51], 'tyrosine': [52, 152], 'similar': [55], 'insulin': [60, 139], 'receptor.': [61], 'Methods': [62], 'and': [63, 83, 104, 110, 130, 154, 198, 220, 232], 'Findings': [64], 'Here': [65], 'we': [66], 'show': [67, 142], 'this': [69, 91], 'receptor': [70], 'is': [71, 147, 164], 'member': [73], 'new': [76, 88, 224], 'RTKs': [79, 216], 'found': [80, 180], 'invertebrates,': [82], 'particularly': [84], 'insects.': [86, 102], 'Sixteen': [87], 'members': [89], 'family,': [92], 'named': [93], 'Kinase': [95], 'Receptor': [96], '(VKR),': [97], 'were': [98], 'identified': [99], 'many': [101, 182], 'Structural': [103], 'phylogenetic': [105], 'studies': [106], 'performed': [107], 'on': [108, 151], 'VFT': [109, 121], 'TK': [111, 132], 'domains': [112], 'showed': [113], 'VKR': [115, 146, 207], 'sequences': [116], 'formed': [117], 'monophyletic': [118], 'groups,': [119], 'group': [122], 'being': [123, 134], 'close': [124, 135], 'GABAB': [128], 'one': [133], 'receptors.': [140], 'recombinant': [145], 'able': [148], 'autophosphorylate': [150], 'residues,': [153], 'report': [155], 'it': [157], 'can': [158], 'be': [159], 'activated': [160], 'by': [161], 'L-arginine.': [162], 'This': [163], 'agreement': [166], 'with': [167], 'high': [169, 190], 'degree': [170], 'conservation': [172], 'alpha': [175], 'amino': [176, 183], 'acid': [177, 184], 'binding': [178, 185], 'residues': [179], 'VFTs.': [186], 'The': [187, 213], 'presence': [188], 'levels': [191], 'vkr': [193], 'transcripts': [194], 'larval': [196], 'forms': [197], 'female': [200], 'gonads': [201], 'indicates': [202], 'putative': [204], 'function': [205], 'reproduction': [209], 'and/or': [210], 'development.': [211], 'Conclusion': [212], 'identification': [214], 'specific': [217], 'for': [218, 226], 'parasites': [219], 'insect': [221], 'vectors': [222], 'raises': [223], 'perspectives': [225], 'control': [228], 'human': [230], 'parasitic': [231], 'infectious': [233], 'diseases.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023334359', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T18:31:17.044454', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
