Title: The radiosensitivity of normal and leukaemic human blood lymphocytes
Abstract: Twenty-three experiments have been performed on normal peripheral blood lymphocytes and nine on lymphocytes from the blood of patients with chronic lymphatic leukaemia. The cells are cultured using a modification of the agar method, and then exposed to x-ray radiation. The radiosensitivity of the lymphocytes is estimated by direct cell counts at hourly intervals after various doses of radiation. In both series, the cells decay exponentially. When the normal and leukaemic cells are compared after irradiation by 0, 60 and 120 r, no significant differences in radiosensitivity are found. At 240 r, however, the leukaemic cells were found to be more sensitive than the normal cells. It is possible that other differences noted between normal and non-mitotic chronic lymphatic leukaemic lymphocytes may be correlated with this altered radiosensitivity. It seems unlikely, though that the results can be applied to therapeutic radiation.
Publication Year: 1961
Publication Date: 1961-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 12
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