Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2023187310', 'doi': 'https://doi.org/10.1016/j.juro.2012.02.1498', 'title': '1209 PERSONALIZED PSA TESTING USING GENETIC VARIANTS CAN POSSIBLY DECREASE THE NUMBER OF PROSTATE BIOPSIES', 'display_name': '1209 PERSONALIZED PSA TESTING USING GENETIC VARIANTS CAN POSSIBLY DECREASE THE NUMBER OF PROSTATE BIOPSIES', 'publication_year': 2012, 'publication_date': '2012-04-01', 'ids': {'openalex': 'https://openalex.org/W2023187310', 'doi': 'https://doi.org/10.1016/j.juro.2012.02.1498', 'mag': '2023187310'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2012.02.1498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5107093696', 'display_name': 'Brian T. Helfand', 'orcid': 'https://orcid.org/0000-0002-7707-3318'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian T. Helfand', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031483568', 'display_name': 'Stacy Loeb', 'orcid': 'https://orcid.org/0000-0003-3933-9207'}, 'institutions': [{'id': 'https://openalex.org/I4210107408', 'display_name': 'New York Proton Center', 'ror': 'https://ror.org/01m7v2988', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210107408']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stacy Loeb', 'raw_affiliation_strings': ['New York, NY'], 'affiliations': [{'raw_affiliation_string': 'New York, NY', 'institution_ids': ['https://openalex.org/I4210107408']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101887913', 'display_name': 'Matthias D. Hofer', 'orcid': 'https://orcid.org/0000-0001-8393-2468'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Matthias D. Hofer', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082359466', 'display_name': 'Dae Young Kim', 'orcid': 'https://orcid.org/0000-0002-3022-8888'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dae Y. Kim', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108514375', 'display_name': 'Qiaoyan Hu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Qiaoyan Hu', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036974497', 'display_name': 'Phillip R. Cooper', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Phillip R. Cooper', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109337967', 'display_name': 'Barry B. McGuire', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Barry B. McGuire', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065869555', 'display_name': 'William J. Catàlona', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'William J. Catalona', 'raw_affiliation_strings': ['Chicago, IL'], 'affiliations': [{'raw_affiliation_string': 'Chicago, IL', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.503, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.63143, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 75}, 'biblio': {'volume': '187', 'issue': '4S', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9668, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9668, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9662, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.70176816}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66775244}, {'id': 'https://openalex.org/C2780673598', 'wikidata': 'https://www.wikidata.org/wiki/Q285223', 'display_name': 'Genetic testing', 'level': 2, 'score': 0.54046416}, {'id': 'https://openalex.org/C2993967602', 'wikidata': 'https://www.wikidata.org/wiki/Q5532932', 'display_name': 'Genetic variants', 'level': 4, 'score': 0.49486417}, {'id': 'https://openalex.org/C2781406297', 'wikidata': 'https://www.wikidata.org/wiki/Q409450', 'display_name': 'Prostate-specific antigen', 'level': 4, 'score': 0.4625117}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.44969448}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4099925}, {'id': 'https://openalex.org/C74909509', 'wikidata': 'https://www.wikidata.org/wiki/Q10387', 'display_name': 'Gerontology', 'level': 1, 'score': 0.34559172}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.26699454}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2401888}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20720425}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.120716095}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.10689062}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2012.02.1498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.5}], 'grants': [{'funder': 'https://openalex.org/F4320333106', 'funder_display_name': 'Robert H. Lurie Comprehensive Cancer Center', 'award_id': 'P30 CA60553'}], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W846826746', 'https://openalex.org/W4255120256', 'https://openalex.org/W3171449477', 'https://openalex.org/W299695548', 'https://openalex.org/W2381163510', 'https://openalex.org/W2376423713', 'https://openalex.org/W2088520467', 'https://openalex.org/W2075763133', 'https://openalex.org/W2031954916', 'https://openalex.org/W1583600832'], 'abstract_inverted_index': {'You': [0], 'have': [1, 193, 409], 'accessJournal': [2], 'of': [3, 173, 211, 237, 283, 337, 366, 376, 398, 463, 486], 'UrologyProstate': [4], 'Cancer:': [5], 'Detection': [6], 'and': [7, 45, 137, 294, 312, 373, 437, 480, 495, 513], 'Screening': [8], 'I1': [9], 'Apr': [10], '20121209': [11], 'PERSONALIZED': [12], 'PSA': [13, 164, 182, 201, 230, 250, 278, 289, 305, 316, 343, 356, 367, 375, 384, 392, 399, 430, 453, 469], 'TESTING': [14], 'USING': [15], 'GENETIC': [16], 'VARIANTS': [17], 'CAN': [18], 'POSSIBLY': [19], 'DECREASE': [20], 'THE': [21], 'NUMBER': [22], 'OF': [23], 'PROSTATE': [24], 'BIOPSIES': [25], 'Brian': [26, 49, 517], 'T.': [27, 50, 52, 518], 'Helfand,': [28], 'Stacy': [29, 62, 527], 'Loeb,': [30], 'Matthias': [31, 74, 537], 'D.': [32, 75, 77, 538], 'Hofer,': [33], 'Dae': [34, 87, 547], 'Y.': [35, 88, 90, 548], 'Kim,': [36], 'Qiaoyan': [37, 100, 557], 'Hu,': [38], 'Phillip': [39, 111, 566], 'R.': [40, 112, 114, 567], 'Cooper,': [41], 'Barry': [42, 124, 576], 'B.': [43, 125, 127, 577], 'McGuire,': [44], 'William': [46, 138, 586], 'J.': [47, 139, 141, 587], 'Catalona': [48, 142, 588], 'HelfandBrian': [51], 'Helfand': [53, 519], 'Chicago,': [54, 79, 92, 103, 116, 129, 143, 520, 540, 550, 559, 569, 579, 589], 'IL': [55, 80, 93, 104, 117, 130, 144, 521, 541, 551, 560, 570, 580, 590], 'More': [56, 68, 81, 94, 105, 118, 131, 145, 522, 532, 542, 552, 561, 571, 581, 591], 'articles': [57, 69, 82, 95, 106, 119, 132, 146, 523, 533, 543, 553, 562, 572, 582, 592], 'by': [58, 70, 83, 96, 107, 120, 133, 147, 217, 314, 318, 458, 490, 508, 524, 534, 544, 554, 563, 573, 583, 593], 'this': [59, 71, 84, 97, 108, 121, 134, 148, 525, 535, 545, 555, 564, 574, 584, 594], 'author': [60, 72, 85, 98, 109, 122, 135, 149, 526, 536, 546, 556, 565, 575, 585, 595], ',': [61, 73, 86, 99, 110, 123, 136], 'LoebStacy': [63], 'Loeb': [64, 528], 'New': [65, 529], 'York,': [66, 530], 'NY': [67, 531], 'HoferMatthias': [76], 'Hofer': [78, 539], 'KimDae': [89], 'Kim': [91, 549], 'HuQiaoyan': [101], 'Hu': [102, 558], 'CooperPhillip': [113], 'Cooper': [115, 568], 'McGuireBarry': [126], 'McGuire': [128, 578], 'CatalonaWilliam': [140], 'View': [150], 'All': [151, 597], 'Author': [152], 'Informationhttps://doi.org/10.1016/j.juro.2012.02.1498AboutPDF': [153], 'ToolsAdd': [154], 'to': [155, 180, 185, 246, 258, 271, 333, 408, 434, 476], 'favoritesDownload': [156], 'CitationsTrack': [157], 'CitationsPermissionsReprints': [158], 'ShareFacebookTwitterLinked': [159], 'InEmail': [160], 'INTRODUCTION': [161], 'AND': [162], 'OBJECTIVES': [163], 'testing': [165, 183], 'has': [166], 'limited': [167], 'performance': [168, 484], 'characteristics': [169, 485], 'for': [170, 234, 298, 308, 357, 362, 460], 'the': [171, 235, 256, 335, 354, 382, 390, 396, 426, 461, 482], 'diagnosis': [172], 'prostate': [174, 261, 411], 'cancer': [175], '(CaP).': [176], 'A': [177], 'promising': [178], 'possibility': [179], 'improve': [181, 481], 'is': [184, 386], 'integrate': [186], 'a': [187, 248, 260, 363, 374, 410, 435, 451], "patient's": [188], 'genetic': [189, 196, 277, 285, 321, 368, 383, 414, 429, 465], 'information.': [190], 'Recent': [191], 'studies': [192], 'identified': [194], '4': [195, 284, 464], 'variants': [197, 219, 239, 286, 369, 400, 466], 'associated': [198, 287], 'with': [199, 214, 288, 360, 395], 'increased': [200], 'levels': [202, 290], '(Sci': [203, 326], 'Trans': [204, 327], 'Med': [205], '2010.': [206], '2(62):62).': [207], 'The': [208, 281], 'increase': [209], 'risk': [210], 'being': [212], 'diagnosed': [213], 'CaP': [215], 'conferred': [216], 'these': [218, 238], 'may': [220, 243], 'be': [221, 244, 406, 456, 474], 'mediated': [222], 'principally': [223], 'through': [224], 'their': [225, 319], 'effects': [226, 236], 'on': [227, 240], 'increasing': [228], 'serum': [229], 'levels.': [231, 470], 'By': [232], 'correcting': [233], 'PSA,': [241], 'it': [242], 'possible': [245], 'create': [247], 'personalized': [249, 452], 'cutoff': [251], 'that': [252, 389, 450, 467], 'can': [253, 455, 473], 'better': [254], 'inform': [255], 'decision': [257], 'recommend': [259], 'biopsy.': [262], 'We': [263], 'therefore': [264], 'determined': [265, 297, 353], 'how': [266], 'many': [267], 'men': [268, 338, 359, 404], 'would': [269, 340, 405, 432], 'continue': [270], 'meet': [272, 341], 'common': [273], 'biopsy': [274, 412, 427], 'criteria': [275], 'after': [276, 413], 'correction.': [279], 'METHODS': [280], 'genotypes': [282, 361], '(rs2736098,': [291], 'rs10788160,': [292], 'rs11067228,': [293], 'rs17632542)': [295], 'were': [296, 310, 331], '964': [299], 'Caucasian': [300], 'healthy': [301], 'volunteers': [302], 'from': [303, 371], '2003-2011.': [304], 'values': [306, 317, 472], 'adjusted': [307, 355, 391], 'genotype': [309], 'calculated': [311], 'weighted': [313, 387], 'dividing': [315], 'combined': [320], 'risk,': [322], 'as': [323, 425], 'previously': [324], 'described': [325], 'Med).': [328], 'Statistical': [329], 'analyses': [330], 'used': [332, 475], 'compare': [334], 'percentage': [336], 'who': [339], 'commonly-used': [342], 'thresholds': [344], '(>2.5': [345], 'or': [346, 422], '4.0ng/ml).': [347], 'RESULTS': [348], 'As': [349, 380], 'an': [350], 'example,': [351, 419], 'we': [352], 'hypothetical': [358], 'variable': [364], 'number': [365, 397], '(ranging': [370], '0-4)': [372], '2.5ng/ml': [377], '(Table': [378, 416], '1).': [379], 'demonstrated,': [381], 'correction': [385, 431], 'so': [388], 'value': [393, 454], 'decreases': [394], 'carried.': [401], 'Significantly': [402], 'fewer': [403], 'recommended': [407], 'adjustment': [415], '2).': [417], 'For': [418], 'using': [420], '2.5': [421], '4.0': [423], 'ng/ml': [424], 'threshold,': [428], 'lead': [433], '15%': [436], '20%': [438], 'relative': [439], 'reduction': [440], 'in': [441], 'potentially': [442], 'unnecessary': [443, 478], 'biopsies,': [444], 'respectively.': [445], 'CONCLUSIONS': [446], 'Our': [447], 'results': [448], 'suggest': [449], 'obtained': [457], 'adjusting': [459], 'presence': [462], 'influence': [468], 'These': [471], 'prevent': [477], 'biopsies': [479], 'clinical': [483], 'PSA.': [487], '©': [488], '2012': [489, 507], 'American': [491, 509], 'Urological': [492, 510], 'Association': [493, 511], 'Education': [494, 512], 'Research,': [496, 514], 'Inc.FiguresReferencesRelatedDetails': [497], 'Volume': [498], '187Issue': [499], '4SApril': [500], '2012Page:': [501], 'e489': [502], 'Advertisement': [503, 598, 599], 'Copyright': [504], '&': [505], 'Permissions©': [506], 'Inc.MetricsAuthor': [515], 'Information': [516], 'Expand': [596], 'PDF': [600], 'downloadLoading': [601], '...': [602]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023187310', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-07T17:05:29.862517', 'created_date': '2016-06-24'}