Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2023182177', 'doi': 'https://doi.org/10.1093/cvr/7.4.482', 'title': 'Digitoxin treatment and experimental cardiac hypertrophy in the rat', 'display_name': 'Digitoxin treatment and experimental cardiac hypertrophy in the rat', 'publication_year': 1973, 'publication_date': '1973-07-01', 'ids': {'openalex': 'https://openalex.org/W2023182177', 'doi': 'https://doi.org/10.1093/cvr/7.4.482', 'mag': '2023182177', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4269104'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/cvr/7.4.482', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045600308', 'display_name': 'Heikki Turto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102054', 'display_name': 'Wihuri Research Institute', 'ror': 'https://ror.org/01jbjy689', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210102054']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'H. TURTO', 'raw_affiliation_strings': ['From the Wihuri Research Institute, Helsinki, and the Department of Medical Chemistry, University of Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'From the Wihuri Research Institute, Helsinki, and the Department of Medical Chemistry, University of Helsinki, Finland', 'institution_ids': ['https://openalex.org/I4210102054', 'https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062065480', 'display_name': 'Seppo Lindy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102054', 'display_name': 'Wihuri Research Institute', 'ror': 'https://ror.org/01jbjy689', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210102054']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'S. LINDY', 'raw_affiliation_strings': ['From the Wihuri Research Institute, Helsinki, and the Department of Medical Chemistry, University of Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'From the Wihuri Research Institute, Helsinki, and the Department of Medical Chemistry, University of Helsinki, Finland', 'institution_ids': ['https://openalex.org/I4210102054', 'https://openalex.org/I133731052']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4177, 'currency': 'EUR', 'value_usd': 4504, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.21, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.74451, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '7', 'issue': '4', 'first_page': '482', 'last_page': '489'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9095, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9095, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/digitoxin', 'display_name': 'Digitoxin', 'score': 0.882264}, {'id': 'https://openalex.org/keywords/abdominal-aorta', 'display_name': 'Abdominal aorta', 'score': 0.6635225}, {'id': 'https://openalex.org/keywords/myocardial-hypertrophy', 'display_name': 'Myocardial hypertrophy', 'score': 0.59757555}], 'concepts': [{'id': 'https://openalex.org/C3018791406', 'wikidata': 'https://www.wikidata.org/wiki/Q945225', 'display_name': 'Cardiac hypertrophy', 'level': 3, 'score': 0.9004884}, {'id': 'https://openalex.org/C2780628665', 'wikidata': 'https://www.wikidata.org/wiki/Q423890', 'display_name': 'Digitoxin', 'level': 4, 'score': 0.882264}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6993358}, {'id': 'https://openalex.org/C2780520971', 'wikidata': 'https://www.wikidata.org/wiki/Q2264329', 'display_name': 'Abdominal aorta', 'level': 3, 'score': 0.6635225}, {'id': 'https://openalex.org/C167414201', 'wikidata': 'https://www.wikidata.org/wiki/Q1955391', 'display_name': 'Muscle hypertrophy', 'level': 2, 'score': 0.6367869}, {'id': 'https://openalex.org/C3018418570', 'wikidata': 'https://www.wikidata.org/wiki/Q1729124', 'display_name': 'Myocardial hypertrophy', 'level': 3, 'score': 0.59757555}, {'id': 'https://openalex.org/C2779980429', 'wikidata': 'https://www.wikidata.org/wiki/Q101004', 'display_name': 'Aorta', 'level': 2, 'score': 0.5970287}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.49853468}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.46693653}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44522282}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.13144419}, {'id': 'https://openalex.org/C2777707475', 'wikidata': 'https://www.wikidata.org/wiki/Q422222', 'display_name': 'Digoxin', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006332', 'descriptor_name': 'Cardiomegaly', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004074', 'descriptor_name': 'Digitoxin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001012', 'descriptor_name': 'Aorta, Abdominal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006332', 'descriptor_name': 'Cardiomegaly', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D006332', 'descriptor_name': 'Cardiomegaly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003250', 'descriptor_name': 'Constriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004074', 'descriptor_name': 'Digitoxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004074', 'descriptor_name': 'Digitoxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008026', 'descriptor_name': 'Ligation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014316', 'descriptor_name': 'Tritium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014529', 'descriptor_name': 'Uridine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014529', 'descriptor_name': 'Uridine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/cvr/7.4.482', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4269104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.75, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4252900795', 'https://openalex.org/W2418918067', 'https://openalex.org/W2409722245', 'https://openalex.org/W2398022584', 'https://openalex.org/W2380997073', 'https://openalex.org/W2369097129', 'https://openalex.org/W2325967692', 'https://openalex.org/W2279530554', 'https://openalex.org/W2019052410', 'https://openalex.org/W1968227629'], 'abstract_inverted_index': {'Cardiac': [0], 'hypertrophy': [1, 78], 'was': [2, 59], 'produced': [3], 'in': [4, 29, 41, 51, 61], 'rats': [5], 'by': [6], 'constricting': [7], 'the': [8, 12, 17, 19, 27, 30, 52, 66, 76], 'abdominal': [9], 'aorta.': [10, 67], 'When': [11], 'animals': [13, 62], 'were': [14], 'digitalized': [15], 'before': [16], 'operation': [18], 'development': [20], 'of': [21, 34, 43, 56, 65], 'cardiac': [22, 77], 'hypertrophy,': [23], 'as': [24, 26, 72], 'well': [25], 'increase': [28, 49], 'content': [31, 53], 'and': [32, 54], 'labelling': [33, 55], 'myocardial': [35, 57], 'proteins,': [36], 'could': [37], 'be': [38], 'prevented.': [39], 'However,': [40], 'spite': [42], 'treatment': [44, 74], 'with': [45, 63, 81], 'digitoxin': [46, 73], 'a': [47, 85], 'significant': [48], 'both': [50], 'RNA': [58, 92], 'seen': [60], 'constriction': [64], 'The': [68], 'results': [69], 'indicate': [70], 'that': [71], 'prevents': [75], 'it': [79], 'interferes': [80], 'protein': [82], 'synthesis': [83], 'through': [84], 'mechanism': [86], 'which': [87], 'has': [88], 'smaller': [89], 'effects': [90], 'on': [91], 'synthesis.': [93]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2023182177', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-31T14:26:21.253581', 'created_date': '2016-06-24'}