Publication Information

{'id': 'https://openalex.org/W2022987027', 'doi': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'title': 'Binding structure of the leucine aminopeptidase inhibitor microginin FR1', 'display_name': 'Binding structure of the leucine aminopeptidase inhibitor microginin FR1', 'publication_year': 2006, 'publication_date': '2006-12-04', 'ids': {'openalex': 'https://openalex.org/W2022987027', 'doi': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'mag': '2022987027', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17157838'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057682213', 'display_name': 'Manuel Kraft', 'orcid': 'https://orcid.org/0000-0001-6764-2970'}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Manuel Kraft', 'raw_affiliation_strings': ['Institut für Biologie II, Microbiologie, Albert-Ludwigs-Universität, Schänzlestr. 1, D-79104 Freiburg im Breisgau, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Biologie II, Microbiologie, Albert-Ludwigs-Universität, Schänzlestr. 1, D-79104 Freiburg im Breisgau, Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090633700', 'display_name': 'Christian Schleberger', 'orcid': 'https://orcid.org/0000-0002-5601-1724'}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christian Schleberger', 'raw_affiliation_strings': ['Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universität, Albertstr. 21, D‐79104 Freiburg im Breisgau, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universität, Albertstr. 21, D‐79104 Freiburg im Breisgau, Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113990892', 'display_name': 'J. Weckesser', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jürgen Weckesser', 'raw_affiliation_strings': ['Institut für Biologie II, Microbiologie, Albert-Ludwigs-Universität, Schänzlestr. 1, D-79104 Freiburg im Breisgau, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Biologie II, Microbiologie, Albert-Ludwigs-Universität, Schänzlestr. 1, D-79104 Freiburg im Breisgau, Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5104130781', 'display_name': 'Georg E. Schulz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Georg E. Schulz', 'raw_affiliation_strings': ['Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universität, Albertstr. 21, D‐79104 Freiburg im Breisgau, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universität, Albertstr. 21, D‐79104 Freiburg im Breisgau, Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.335, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.797746, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '580', 'issue': '30', 'first_page': '6943', 'last_page': '6947'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exopeptidase', 'display_name': 'Exopeptidase', 'score': 0.7637322}], 'concepts': [{'id': 'https://openalex.org/C2780985610', 'wikidata': 'https://www.wikidata.org/wiki/Q419527', 'display_name': 'Aminopeptidase', 'level': 4, 'score': 0.9233223}, {'id': 'https://openalex.org/C54374919', 'wikidata': 'https://www.wikidata.org/wiki/Q421015', 'display_name': 'Exopeptidase', 'level': 3, 'score': 0.7637322}, {'id': 'https://openalex.org/C2776580952', 'wikidata': 'https://www.wikidata.org/wiki/Q483745', 'display_name': 'Leucine', 'level': 3, 'score': 0.724492}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5638461}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52275133}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.33453044}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.30459872}], 'mesh': [{'descriptor_ui': 'D007931', 'descriptor_name': 'Leucyl Aminopeptidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007931', 'descriptor_name': 'Leucyl Aminopeptidase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007931', 'descriptor_name': 'Leucyl Aminopeptidase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D007931', 'descriptor_name': 'Leucyl Aminopeptidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046931', 'descriptor_name': 'Microcystis', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D046931', 'descriptor_name': 'Microcystis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020836', 'descriptor_name': 'Protein Structure, Quaternary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17157838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.febslet.2006.11.060', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.48, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1598654182', 'https://openalex.org/W1969173610', 'https://openalex.org/W1988568413', 'https://openalex.org/W1989806335', 'https://openalex.org/W1994306371', 'https://openalex.org/W1995017064', 'https://openalex.org/W1995102906', 'https://openalex.org/W2000840258', 'https://openalex.org/W2002146198', 'https://openalex.org/W2003107936', 'https://openalex.org/W2004745717', 'https://openalex.org/W2019099032', 'https://openalex.org/W2020390356', 'https://openalex.org/W2021823971', 'https://openalex.org/W2024507420', 'https://openalex.org/W2035007786', 'https://openalex.org/W2038840577', 'https://openalex.org/W2042854316', 'https://openalex.org/W2046137490', 'https://openalex.org/W2048521920', 'https://openalex.org/W2056540548', 'https://openalex.org/W2058011207', 'https://openalex.org/W2058381750', 'https://openalex.org/W2074525235', 'https://openalex.org/W2080048885', 'https://openalex.org/W2084316738', 'https://openalex.org/W2087103161', 'https://openalex.org/W2096555055', 'https://openalex.org/W2114367386', 'https://openalex.org/W2143694829', 'https://openalex.org/W2144081223', 'https://openalex.org/W2148150393', 'https://openalex.org/W3214745685', 'https://openalex.org/W649770388'], 'related_works': ['https://openalex.org/W2599453198', 'https://openalex.org/W2084159218', 'https://openalex.org/W2081952712', 'https://openalex.org/W2051730930', 'https://openalex.org/W2051687768', 'https://openalex.org/W2009948972', 'https://openalex.org/W1967771459', 'https://openalex.org/W170435099', 'https://openalex.org/W1675997988', 'https://openalex.org/W1225922708'], 'abstract_inverted_index': {'Natural': [0], 'bioactive': [1], 'compounds': [2], 'are': [3, 23], 'of': [4, 34, 62], 'general': [5], 'interest': [6], 'for': [7, 59], 'pharmaceutical': [8], 'research': [9], 'because': [10], 'they': [11], 'may': [12], 'serve': [13], 'as': [14], 'leads': [15], 'in': [16], 'drug': [17], 'development': [18], 'campaigns.': [19], 'Among': [20], 'them,': [21], 'microginins': [22], 'linear': [24], 'peptides': [25], 'known': [26], 'to': [27, 41], 'inhibit': [28], 'various': [29], 'exopeptidases.': [30], 'The': [31, 52], 'crystal': [32], 'structure': [33, 55], 'microginin': [35], 'FR1': [36], 'from': [37], 'Microcystis': [38], 'sp.': [39], 'bound': [40], 'bovine': [42], 'lens': [43], 'leucine': [44], 'aminopeptidase': [45, 64], 'was': [46], 'established': [47], 'at': [48], '1.73': [49], 'Å': [50], 'resolution.': [51], 'observed': [53], 'binding': [54], 'could': [56], 'be': [57], 'beneficial': [58], 'the': [60], 'design': [61], 'potent': [63], 'inhibitors.': [65]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022987027', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-11T04:45:54.413034', 'created_date': '2016-06-24'}