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4136, 4210, 4242, 4275, 4316, 4346, 4494, 4525, 4581, 5093, 5643, 5734, 5758, 5776], 'levels': [12, 166, 1524, 3927, 4056, 4134, 4238, 4272, 4303, 4317, 4347, 4366, 5350, 5571, 5605], 'and': [13, 42, 73, 81, 136, 167, 196, 227, 235, 290, 318, 398, 503, 741, 810, 821, 960, 984, 1146, 1403, 1443, 1525, 1535, 1569, 1573, 1585, 1645, 1732, 1785, 1840, 1899, 2002, 2016, 2034, 2050, 2144, 2171, 2202, 2255, 2371, 2387, 2446, 2454, 2461, 2509, 2553, 2596, 2607, 2630, 2672, 2683, 2717, 2776, 2824, 2857, 2872, 2888, 2901, 2904, 2918, 2944, 2967, 2977, 2992, 3008, 3130, 3150, 3158, 3283, 3318, 3367, 3537, 3580, 3642, 3722, 3916, 3967, 4111, 4129, 4142, 4211, 4223, 4235, 4328, 4336, 4378, 4421, 4441, 4465, 4480, 4501, 4526, 4545, 4665, 4672, 4747, 4750, 4767, 4777, 4785, 4840, 4855, 4891, 5080, 5094, 5264, 5485, 5536, 5549, 5563, 5574, 5698, 5759, 5915, 5919, 5932, 6000, 6048, 6123, 6204, 6226, 6405, 6409, 6416, 6424], 'stimulating': [14, 168], 'T': [15, 169], 'cell': [16, 170, 396, 401, 641, 2045, 2605, 2836], 'factor': [17, 171, 374, 2175, 2293, 5930], '(TCF)/LEF-1-dependent': [18, 172], 'transcription.': [19, 173, 2459, 4616], 'We': [20, 174, 2391, 3107, 3902, 4121, 4629, 6198, 6221, 6255, 6280, 6381, 6419], 'have': [21, 175, 818, 1166, 1901, 4683, 5068, 5491, 6256], 'identified': [22, 176, 1276, 1824, 3842, 5864], 'a': [23, 122, 177, 276, 539, 795, 1139, 1177, 1231, 1244, 1274, 1407, 1581, 1754, 1786, 1826, 2062, 2281, 2287, 2587, 2689, 2770, 2980, 3027, 3032, 3337, 3533, 3776, 3951, 4418, 4422, 4447, 4691, 4900, 5070, 5794, 6211, 6310], 'new': [24, 178, 5071], 'Dvl-mediated': [25, 126, 179, 280, 6054], 'pathway': [27, 181, 3875, 4117, 4625, 5074, 5639, 5644, 5730, 5735, 5777], 'in': [28, 35, 87, 111, 125, 182, 189, 241, 265, 279, 322, 391, 507, 521, 733, 787, 954, 979, 991, 1118, 1138, 1172, 1243, 1285, 1495, 1504, 1756, 1842, 2000, 2038, 2057, 2060, 2191, 2374, 2467, 2586, 2742, 2767, 2896, 2933, 2990, 3140, 3247, 3335, 3358, 3452, 3539, 3563, 3574, 3607, 3637, 3649, 3672, 3705, 3748, 3766, 3780, 3878, 3954, 4057, 4118, 4137, 4145, 4244, 4314, 4323, 4348, 4353, 4408, 4415, 4450, 4458, 4517, 4532, 4641, 4781, 4796, 4837, 4893, 4903, 4907, 4930, 5017, 5053, 5085, 5157, 5177, 5197, 5267, 5273, 5294, 5364, 5481, 5494, 5538, 5542, 5696, 5720, 5755, 5804, 5820, 5857, 5970, 5993, 6038, 6053, 6068, 6071, 6095, 6113, 6151, 6210, 6218, 6287, 6298, 6302, 6348], 'that': [29, 146, 183, 300, 635, 735, 896, 1168, 1514, 1526, 1643, 1844, 2006, 2393, 2407, 2418, 2426, 3253, 3271, 3280, 3341, 3490, 3598, 3683, 3742, 3759, 3904, 3961, 4040, 4087, 4095, 4311, 4472, 4481, 4493, 4502, 4513, 4596, 4603, 4631, 4771, 5100, 5160, 5193, 5253, 5331, 5528, 5631, 5716, 5752, 6046, 6064, 6075, 6089, 6223, 6249, 6305, 6356], 'mouse': [30, 184, 1029, 1408, 2634, 2644, 3303, 3316, 3354, 3365, 3475, 3630], 'Dvl': [31, 91, 147, 185, 245, 301, 2366, 2384, 2394, 2408, 2419, 2674, 2987, 2999, 3024, 3113, 3244, 3272, 3304, 3618, 3691, 3761, 3892, 4096, 4110, 4528, 4539, 4604, 4640, 5077, 5194, 5537, 5708, 5747, 6110, 6261], 'proteins,': [32, 186, 962, 986, 4682], 'when': [33, 187, 3448, 3764], 'expressed': [34, 188, 2383, 3451, 3636, 3704, 3765], 'COS-7': [36, 190, 2460, 2507, 3310, 3564, 3638, 3767, 4349, 4894, 4908, 6219, 6349], 'cells,': [37, 191, 2376, 3707, 3768], 'stimulate': [38, 192, 2396, 4498, 4588, 4599, 6079], 'c-Jun-dependent': [39, 193, 5082], 'transcription': [40, 86, 194, 240, 1890, 2174, 2389, 2401, 3096, 3259, 3265, 4380, 4486, 4590, 4601, 4645, 5084, 5546, 6081], 'activity': [41, 45, 195, 199, 1542, 1904, 3058, 3120, 3334, 4452, 4460, 4500, 4508, 4516, 4555, 5768, 6235], 'the': [43, 47, 100, 130, 197, 201, 254, 284, 496, 532, 636, 647, 652, 656, 748, 792, 952, 980, 1028, 1115, 1119, 1123, 1128, 1169, 1214, 1222, 1226, 1400, 1417, 1425, 1487, 1522, 1527, 1533, 1586, 1654, 1734, 1758, 1854, 1893, 1910, 2039, 2123, 2165, 2181, 2259, 2379, 2403, 2416, 2427, 2494, 2526, 2604, 2617, 2643, 2648, 2651, 2666, 2670, 2727, 2730, 2777, 2793, 2832, 2897, 2934, 2948, 2956, 2995, 3001, 3023, 3041, 3057, 3085, 3098, 3110, 3122, 3143, 3153, 3345, 3463, 3520, 3541, 3569, 3599, 3614, 3624, 3655, 3681, 3690, 3696, 3700, 3717, 3725, 3728, 3734, 3743, 3757, 3760, 3844, 3873, 3896, 3911, 3932, 3940, 3943, 4041, 4054, 4107, 4115, 4133, 4232, 4262, 4271, 4312, 4315, 4345, 4359, 4365, 4473, 4491, 4514, 4533, 4553, 4558, 4574, 4577, 4580, 4623, 4637, 4650, 4676, 4741, 4755, 4772, 4842, 4856, 4914, 4925, 5036, 5092, 5101, 5229, 5256, 5268, 5271, 5276, 5288, 5291, 5303, 5334, 5343, 5349, 5358, 5423, 5431, 5554, 5568, 5627, 5632, 5637, 5642, 5705, 5723, 5728, 5733, 5744, 5757, 5775, 5783, 5787, 5858, 5911, 6087, 6106, 6147, 6152, 6283, 6294, 6365, 6386, 6429], 'kinase': [44, 50, 198, 204, 321, 354, 366, 2551, 2908, 2923, 3161, 3162, 5998], 'of': [46, 55, 68, 79, 84, 104, 134, 200, 209, 222, 233, 238, 258, 288, 316, 325, 385, 395, 400, 498, 514, 534, 542, 544, 640, 655, 729, 794, 798, 1100, 1122, 1141, 1180, 1217, 1225, 1246, 1410, 1416, 1424, 1498, 1516, 1521, 1530, 1588, 1653, 1760, 1892, 2014, 2064, 2116, 2125, 2168, 2180, 2284, 2290, 2381, 2402, 2430, 2452, 2457, 2504, 2512, 2593, 2633, 2669, 2678, 2711, 2729, 2769, 2843, 2863, 2875, 2899, 2936, 2939, 2947, 2958, 2997, 3003, 3016, 3022, 3040, 3052, 3059, 3080, 3097, 3105, 3112, 3132, 3134, 3146, 3156, 3166, 3300, 3353, 3364, 3443, 3462, 3470, 3474, 3484, 3501, 3519, 3550, 3568, 3602, 3609, 3617, 3629, 3662, 3699, 3727, 3736, 3846, 3880, 4044, 4052, 4109, 4127, 4135, 4239, 4267, 4273, 4280, 4304, 4321, 4358, 4367, 4417, 4552, 4557, 4564, 4579, 4607, 4614, 4619, 4643, 4675, 4679, 4693, 4745, 4754, 4775, 4783, 4798, 4913, 5040, 5174, 5255, 5259, 5270, 5275, 5290, 5296, 5333, 5336, 5351, 5360, 5544, 5556, 5572, 5606, 5707, 5722, 5746, 5811, 5860, 6028, 6101, 6149, 6216, 6233, 6259, 6265, 6285, 6296, 6337, 6367], 'c-Jun': [48, 202, 319, 364, 2170, 3004, 3081, 3285], 'N-terminal': [49, 203, 320, 365, 1268, 1394, 1528, 3529], '(JNK).': [51, 205], 'The': [52, 206, 341, 382, 779, 1267, 1564, 2184, 2528, 2627, 2676, 2699, 2835, 2884, 2922, 2951, 2963, 2973, 3351, 3524, 3548, 3566, 3838, 4237, 4302, 4456, 4594, 4617, 5369, 5479, 5701, 5739, 6073], 'DEP': [53, 207, 1232, 1238, 2428, 3656, 3701, 3729, 3744, 3941, 4608, 5102, 5292, 5344], 'domain': [54, 208, 1171, 1216, 1228, 1270, 1395, 2429, 3507, 3543, 3730, 3745, 5103, 5293, 5345], 'Dvl1': [56, 210, 2635], 'is': [57, 211, 345, 933, 940, 948, 1114, 1229, 1396, 1493, 1500, 1538, 2280, 2413, 2432, 2591, 2988, 3356, 3572, 3619, 3658, 3724, 3746, 3753, 3775, 3958, 4089, 4495, 4571, 5104, 5281, 5736, 5809, 5816, 5855, 6066, 6099, 6143], 'essential': [58, 212], 'for': [59, 77, 82, 213, 231, 236, 649, 805, 1213, 1540, 1792, 2434, 2450, 2455, 2506, 2514, 2548, 2575, 2851, 2879, 2927, 3126, 3468, 3621, 3644, 3660, 3686, 3848, 4091, 4213, 4340, 4612, 5043, 5075, 5106, 5171, 5774, 5786, 6146, 6312, 6363, 6378, 6385, 6392, 6399, 6412, 6427], 'JNK': [60, 112, 127, 142, 150, 214, 266, 281, 296, 304, 2120, 2163, 2189, 2285, 2435, 3281, 3301, 3320, 3338, 3440, 3444, 3556, 3586, 3622, 3645, 3687, 3713, 3740, 3749, 3771, 3874, 3889, 3907, 3955, 4092, 4688, 4733, 4763, 4787, 4800, 4808, 4849, 4863, 4905, 4929, 5016, 5049, 5062, 5079, 5107, 5165, 5196, 5495, 5539, 5638, 5724, 5729, 5760, 5788, 5805, 5821, 5897, 5925, 5972, 6004, 6029, 6039, 6055, 6069, 6112, 6208, 6234, 6252, 6271, 6288, 6344, 6370, 6379], 'activation.': [61, 143, 215, 297, 2436, 3646, 3890, 3956, 4801, 5050, 5063, 5108, 6056, 6289, 6371, 6380], 'By': [62, 216, 2437], 'contrast,': [63, 217, 2438], 'all': [64, 218, 1101, 2439, 5971, 6258], 'three': [65, 219, 1026, 2440, 3498, 3512], 'conserved': [66, 220, 786, 1110, 1269, 2441, 3506, 3521, 5257, 6023], 'domains': [67, 221, 3522, 5258], 'Dvl,': [69, 223, 4736, 6031], 'including': [70, 224, 1025, 1143, 2443, 4332, 4541, 4663, 5262, 5342], 'DIX,': [71, 225, 2444], 'PDZ,': [72, 226, 2445, 3538, 4335, 4544], 'DEP,': [74, 228, 2447], 'required': [76, 230, 1539, 2433, 2449, 4611, 5105, 5170, 5773, 5785], 'up-regulation': [78, 232, 543, 2451, 5274, 5295], 'stimulation': [83, 237, 2179, 2456, 4551, 4642, 6232], 'LEF-1-mediated': [85, 239, 2458], 'mammalian': [88, 242, 323, 803, 815, 1021, 1505, 1565, 2192, 2375, 3485, 4119, 4931, 5198, 5814, 6019, 6096, 6114, 6201], 'cells.': [89, 243, 3565, 4120, 4350, 4909, 6097, 6115, 6220], 'Thus,': [90, 244, 2109, 3298, 3930, 4649, 5033, 5726], 'can': [92, 246, 1174, 1518, 2367, 2395, 3493, 3963, 4097, 4131, 4521, 4598, 6206], 'lead': [93, 247, 310, 4098], 'two': [95, 249, 312, 2114, 3924, 4100, 4792, 5113, 5904], 'different': [96, 250, 957, 2117, 3925, 4101, 5361, 5367, 5694, 6032, 6376], 'pathways.': [98, 153, 252, 307, 314, 4103, 5096, 5761], 'Furthermore,': [99, 253], 'small': [101, 255, 2198, 4680, 5906], 'G': [102, 256, 4681, 5907, 5933], 'Cdc42': [105, 135, 259, 289, 2203, 2256, 3147, 4671, 4728, 4746, 4776, 4784, 4812, 4843, 4890, 5914, 5918, 6049], 'or': [106, 260, 1132, 3263, 4203, 4251, 4443, 4463, 4562, 4729, 5186, 5541, 6002, 6275], 'Rac1,': [107, 261, 4748], 'which': [108, 262, 522, 1135, 1279, 1491, 2043, 2061, 2262, 2590, 3460, 3502, 3540, 3653, 3669, 3694, 4409, 5001, 5181, 6109], 'involved': [110, 264, 1494, 2056, 2072, 2989, 3606, 3747, 5718, 5754, 5803, 5819, 5856, 5969, 5992, 6052, 6161], 'activation': [113, 267, 2190, 3104, 3133, 3299, 3469, 3661, 4613, 4689, 4734, 4764, 4850, 4864, 4906, 5496, 5540, 5543, 5806, 5822, 5926, 5973, 6005, 6027, 6040, 6070, 6209, 6272, 6345], 'many': [115, 269, 1423, 4921, 5928], 'stimuli,': [116, 270], 'do': [117, 271, 737, 742, 4144, 4475], 'not': [118, 139, 272, 293, 738, 743, 934, 1413, 2052, 2399, 3261, 3456, 3592, 3791, 3947, 4319, 4476, 4548, 4567, 4610, 4654, 5006, 5183, 5427, 5641, 5732, 5779, 5818, 5968, 5991, 6051, 6078, 6092, 6237, 6278, 6342, 6352, 6360], 'appear': [119, 273, 1851, 2053, 3948, 5428], 'play': [121, 275, 1753, 3950, 4899, 5693], 'major': [123, 277], 'role': [124, 278, 1284, 1755, 1788, 3953, 4902, 5289], 'activation,': [128, 282, 3623, 4093, 4788], 'because': [129, 283, 651, 963, 987, 4320], 'dominant': [131, 285, 4742, 4756, 4793, 4844, 5037], 'negative': [132, 286, 4743, 4757, 4794, 4845, 5038], 'mutants': [133, 287, 666, 2632, 3473, 3513, 3525, 3553, 3571, 4113, 4331, 4360, 4744, 4758, 4774, 4795], 'Rac1': [137, 291, 4730, 4778, 4810, 4857, 4892, 6047], 'could': [138, 292, 3255, 3437, 3591, 3769, 4504, 4759, 5346], 'inhibit': [140, 294, 528, 4505, 4761, 5047, 5060], 'Dvl-induced': [141, 295, 4762, 4904], 'This': [144, 298, 1393, 2412, 3595, 3751, 4081, 4470, 4569, 5353, 6354], 'suggests': [145, 299, 3489, 3597, 3741, 4094, 4471, 6355], 'may': [148, 302, 899, 1649, 2409, 3273, 3604, 5355, 5621, 5692, 5703, 5741, 5764, 5801, 6307, 6359, 6374], 'activate': [149, 303, 3257, 3274, 3439, 3555, 3585, 3712, 3739, 3770, 4807, 4928], 'via': [151, 305, 1762, 3323, 5862, 6253], 'novel': [152, 306], 'Regulation': [315, 3079], 'LEF-1': [317, 2700, 4429, 4440, 4479, 4515, 4565, 4664, 5095, 6413], 'cells.Journal': [324], 'Biological': [326], 'ChemistryVol.': [327], '274Issue': [328], '46PreviewDr.': [329], 'Andrew': [330, 764, 917, 4160], 'McMahon': [331, 408, 548], 'was': [332, 1136, 1577, 1727, 1789, 1822, 2530, 2601, 2622, 2686, 2704, 2737, 2765, 3018, 3082, 3245, 3306, 3445, 3450, 3544, 3557, 3703, 3709, 3841, 3876, 3899, 4050, 4413, 4435, 4446, 4461, 4585, 4626, 4633, 4738, 4803, 5010, 5166, 5191, 5483, 5488, 5898, 6267], 'incorrectly': [333], 'listed': [334], 'as': [335, 646, 663, 1127, 1399, 1825, 2523, 2568, 2647, 2740, 2831, 3125, 3633, 3843, 3908, 3910, 4140, 4634, 4636, 4865, 5610, 5714, 6059, 6061, 6309], 'an': [336, 1282, 2945, 3324, 3528, 5282], 'author': [337, 343], 'on': [338, 1905, 2385, 2882, 2969, 3000, 3056, 3103, 3114, 4114, 6369], 'this': [339, 2058, 3094, 3886, 4432, 4518, 5065], 'paper.': [340], 'corrected': [342], 'list': [344], 'shown': [346, 1167, 1728, 1883, 3139, 3279, 3357, 3573, 3648, 4352, 4373, 4685, 4805, 4836, 4919, 5052, 5167, 5192, 5489, 5922], 'above.': [347], 'Full-Text': [348], 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1283, 3685], 'roles': [390, 5695], 'embryonic': [392], 'induction,': [393], 'generation': [394], 'polarity,': [397, 3882], 'specification': [399], 'fate': [402], '(see': [403, 2129], 'reviews,': [404, 2130], 'Refs.': [405, 2131], '1Dickinson': [406], 'M.E.': [407, 547, 828, 3374], 'A.P.': [409, 549, 3827, 5411, 5468, 5678], 'Curr.': [410, 550], 'Opin.': [411, 551], 'Genet.': [412, 552], 'Dev.': [413, 456, 471, 553, 596, 611, 1042, 1065, 1086, 1433, 1555, 1741, 2023, 2078, 3828, 3989, 4004, 4072, 4187, 4293, 5243, 5321, 5412, 5469, 5679, 6132, 6167], '1992;': [414, 427, 554, 567, 670, 848, 3394, 3974, 4028], '2:': [415, 555], '562-566Crossref': [416, 556], 'PubMed': [417, 433, 447, 461, 475, 487, 557, 573, 587, 601, 615, 627, 673, 694, 707, 720, 774, 854, 886, 927, 1011, 1047, 1069, 1091, 1160, 1206, 1262, 1318, 1340, 1361, 1388, 1437, 1479, 1559, 1610, 1635, 1673, 1694, 1721, 1745, 1780, 1816, 1875, 1943, 1970, 1993, 2027, 2082, 2104, 2158, 2221, 2249, 2272, 2312, 2340, 2358, 2759, 3074, 3192, 3220, 3238, 3400, 3432, 3810, 3833, 3867, 3980, 3994, 4008, 4020, 4031, 4076, 4170, 4191, 4297, 4400, 4720, 4830, 4884, 4950, 4978, 4996, 5028, 5126, 5148, 5217, 5247, 5325, 5394, 5417, 5451, 5474, 5519, 5597, 5661, 5684, 5848, 5872, 5890, 5961, 6136, 6171, 6193, 6330], 'Scopus': [418, 434, 448, 462, 476, 488, 558, 574, 588, 602, 616, 628, 674, 721, 775, 887, 928, 1012, 1048, 1070, 1092, 1161, 1207, 1263, 1319, 1341, 1362, 1389, 1438, 1480, 1560, 1611, 1636, 1674, 1695, 1722, 1746, 1781, 1817, 1876, 1944, 1971, 1994, 2028, 2083, 2105, 2159, 2222, 2250, 2273, 2313, 2341, 2359, 2760, 3075, 3193, 3221, 3239, 3433, 3834, 3868, 3981, 3995, 4009, 4021, 4032, 4077, 4171, 4192, 4298, 4401, 4721, 4831, 4885, 4951, 4979, 4997, 5029, 5127, 5149, 5218, 5248, 5326, 5418, 5475, 5520, 5598, 5685, 5849, 5873, 5891, 5962, 6137, 6172, 6194, 6331], '(54)': [419, 559], 'Google': [420, 436, 450, 464, 478, 490, 560, 576, 590, 604, 618, 630, 676, 695, 708, 723, 777, 855, 889, 930, 1014, 1050, 1072, 1094, 1163, 1209, 1265, 1321, 1343, 1364, 1391, 1440, 1482, 1562, 1613, 1638, 1676, 1697, 1724, 1748, 1783, 1819, 1838, 1878, 1946, 1973, 1996, 2030, 2085, 2107, 2142, 2161, 2224, 2252, 2275, 2315, 2343, 2361, 2762, 3077, 3195, 3223, 3241, 3296, 3401, 3435, 3811, 3836, 3870, 3983, 3997, 4011, 4023, 4034, 4079, 4173, 4194, 4300, 4403, 4705, 4723, 4833, 4887, 4953, 4981, 4999, 5031, 5129, 5151, 5220, 5250, 5328, 5395, 5420, 5452, 5477, 5522, 5600, 5662, 5687, 5833, 5851, 5875, 5893, 5946, 5964, 5985, 6016, 6139, 6174, 6196, 6333], 'Scholar,': [421, 437, 451, 465, 479, 561, 577, 591, 605, 619, 677, 696, 709, 856, 1051, 1073, 1322, 1344, 1365, 1614, 1677, 1698, 1947, 1974, 2086, 2225, 2316, 2344, 3196, 3224, 3402, 3812, 3823, 3984, 3998, 4012, 4024, 4174, 4706, 4954, 4982, 5130, 5396, 5407, 5453, 5464, 5663, 5674, 5834, 5876, 5947, 6175], '2Nusse': [422, 562], 'R.': [423, 455, 469, 563, 595, 609, 769, 922, 1039, 1196, 1377, 1431, 1451, 1553, 1710, 1739, 1774, 1805, 1959, 2021, 2076, 2350, 2751, 3066, 3230, 3970, 3988, 4002, 4070, 4165, 4185, 4291, 4393, 4988, 5241, 5319, 5882, 6130, 6165], 'Varmus': [424, 564, 1005, 3971, 6324], 'H.E.': [425, 565, 3972], 'Cell.': [426, 440, 566, 580, 1197, 1309, 1470, 1934, 2095, 2214, 2242, 2305, 2333, 2351, 2752, 3067, 3185, 3213, 3231, 3858, 3973, 4823, 4877, 4943, 4971, 4989, 5139, 5208, 5510, 5588, 5883, 6184], '69:': [428, 568, 3975], '1073-1087Abstract': [429, 569, 3976], 'Full': [430, 444, 570, 584, 851, 881, 883, 1201, 1203, 1259, 1313, 1315, 1474, 1476, 1938, 1940, 2099, 2101, 2153, 2155, 2218, 2246, 2309, 2337, 2355, 2756, 3071, 3189, 3217, 3235, 3397, 3427, 3429, 3862, 3864, 3977, 4715, 4717, 4827, 4881, 4947, 4975, 4993, 5143, 5145, 5212, 5214, 5514, 5516, 5592, 5594, 5843, 5845, 5887, 5956, 5958, 6188, 6190], 'Text': [431, 445, 571, 585, 852, 882, 884, 1202, 1204, 1260, 1314, 1316, 1475, 1477, 1939, 1941, 2100, 2102, 2154, 2156, 2219, 2247, 2310, 2338, 2356, 2757, 3072, 3190, 3218, 3236, 3398, 3428, 3430, 3863, 3865, 3978, 4716, 4718, 4828, 4882, 4948, 4976, 4994, 5144, 5146, 5213, 5215, 5515, 5517, 5593, 5595, 5844, 5846, 5888, 5957, 5959, 6189, 6191], '(832)': [435, 575, 3982], '3Perrimon': [438, 578], 'N.': [439, 579, 1041, 1061, 1077, 1449, 1951, 1982, 2090, 2237, 2328, 3208, 3825, 3853, 4966, 5134, 5203, 5409, 5466, 5505, 5583, 5676, 6179], '1994;': [441, 458, 581, 598, 691, 1044, 3807, 3991, 5391, 5448, 5658], '76:': [442, 582], '781-784Abstract': [443, 583], '(160)': [449, 589], '4Klingensmith': [452, 592, 3985], 'J.': [453, 483, 593, 623, 681, 767, 845, 874, 875, 920, 1002, 1033, 1053, 1190, 1336, 1367, 1373, 1551, 1669, 1700, 1706, 1770, 1776, 1795, 1801, 1923, 1929, 2147, 2348, 2749, 3064, 3228, 3391, 3420, 3421, 3797, 3986, 4016, 4068, 4163, 4183, 4382, 4709, 4986, 5239, 5317, 5381, 5438, 5648, 5837, 5880, 5950, 6321], 'Nusse': [454, 468, 594, 608, 768, 921, 1038, 1430, 1552, 1738, 2020, 2075, 3987, 4001, 4069, 4164, 4184, 4290, 5240, 5318, 6129, 6164], 'Biol.': [457, 597, 846, 876, 1043, 2148, 3392, 3422, 3829, 3990, 4710, 5413, 5470, 5680, 5838, 5951], '166:': [459, 599, 1045, 3992], '396-414Crossref': [460, 600, 3993], '(185)': [463, 603, 3996], '5Cadigan': [466, 606, 3999], 'K.M.': [467, 607, 1429, 1737, 2019, 2074, 4000, 4289, 6128, 6163], 'Genes': [470, 610, 1432, 1554, 1740, 2022, 2077, 4003, 4071, 4186, 4292, 5242, 5320, 6131, 6166], '1997;': [472, 612, 717, 1008, 1157, 1310, 1434, 1471, 1742, 1777, 1835, 1967, 1990, 2024, 2079, 2139, 3293, 4005, 4294, 4702, 5025, 5123, 5830, 5943, 5982, 6013, 6133, 6168, 6327], '11:': [473, 613, 1435, 1743, 2025, 2080, 4006, 4295, 6134, 6169], '3286-3305Crossref': [474, 614, 1436, 1744, 2026, 2081, 4007, 4296, 6135, 6170], '(2228)': [477, 617, 1439, 1747, 2029, 2084, 4010, 4299, 6138, 6173], '6Dale': [480, 620, 4013], 'T.C.': [481, 621, 4014], 'Biochem.': [482, 622, 1254, 2136, 3290, 4015, 4699, 5827, 5940, 5979, 6010], '1998;': [484, 624, 1337, 1358, 1385, 1670, 1691, 1718, 1813, 2096, 2150, 2269, 3859, 4017, 4712, 5140, 5209, 5511, 5589, 5840, 5869, 5953, 6185], '329:': [485, 625, 4018], '209-223Crossref': [486, 626, 4019], '(438)': [489, 629, 4022], 'Scholar).': [491, 631, 724, 778, 890, 1015, 1095, 1164, 1210, 1266, 1392, 1483, 1563, 1639, 1725, 1749, 1820, 1879, 1997, 2031, 2108, 2162, 2253, 2276, 2362, 3078, 3242, 3297, 3837, 3871, 4035, 4080, 4195, 4301, 4404, 4724, 4834, 4888, 5032, 5221, 5421, 5478, 5523, 5688, 5852, 5894, 5986, 6017, 6140, 6197, 6334], 'Genetic': [492, 1998], 'studies': [493, 892, 1999], 'inDrosophila': [494, 6126], 'revealed': [495, 1019, 1107], 'involvement': [497, 6148], '(Dsh),': [500], '(Arm),': [502], 'pangolin': [504], '(Pan,': [505], 'DTcf)': [506], 'Wingless': [508], '(Wg)': [509], 'signaling.': [510], 'A': [511, 3891, 4036, 4327, 4405, 6290], 'genetic': [512, 5154, 5628], 'order': [513], 'these': [515, 3135, 3248, 3491, 3551, 4281, 4791], 'signal': [516, 1496, 3087, 3964, 5072], 'transducers': [517], 'has': [518, 660, 1881, 3277, 4371, 4917], 'been': [519, 819, 1882, 3278, 4372, 4684, 4918], 'established': [520, 3960], 'Wg': [523, 746, 751, 799, 4141, 5432, 6116, 6150], 'acts': [524], 'through': [525, 3965, 4487, 4809, 6118], 'Dsh': [526, 665, 1022, 1517, 2110, 3962, 4143, 5161, 5261, 5338, 5486, 5500, 5609, 5613], 'Zw-3,': [529, 537, 808], 'thus': [530, 3900, 5790], 'relieving': [531], 'suppression': [533, 4782], 'Arm': [535, 545, 1523, 1570, 5185, 5277, 6121], 'with': [538, 1583, 1847, 2369, 2501, 2642, 2792, 2840, 2860, 2892, 2906, 3026, 3172, 3314, 3561, 4084, 4199, 4206, 4285, 4376, 4437, 4573, 4740, 5015, 5112, 5228, 5285, 5612, 6024, 6339], 'net': [540], 'result': [541, 3596, 4570, 5356], '(1Dickinson': [546], 'Recent': [632, 1640], 'results': [633, 2974, 3169, 4086, 4282, 6058], 'suggest': [634, 895, 3270], '(Fz)': [638], 'surface': [642], 'might': [644, 2008], 'function': [645, 2037], 'receptors': [648, 5931, 5935, 6377], 'Wnt,': [650], 'null': [653], 'mutation': [654, 3839, 3887, 3898, 3934, 4652, 5480, 5560, 5691, 5702, 5740], 'Drosophila': [657, 2001, 2032, 4045, 4146, 5158, 5178, 5260, 5337, 5370, 5799], 'fz': [658, 2033], 'gene': [659, 1593, 1829, 1907, 2702, 2719, 2732, 2780, 3101, 4485, 5083], 'similar': [661, 1787], 'phenotypes': [662, 1420, 3793, 5377], 'some': [664], '(7Adler': [667], 'P.N.': [668, 702, 4026], 'Bioessays.': [669, 1156, 4027], '14:': [671, 4029], '735-741Crossref': [672, 4030], '(155)': [675, 4033], '8Theisen': [678], 'H.': [679, 1006, 1328, 1330, 1661, 1663, 1766, 1933, 1965, 1984, 2233, 2324, 3204, 3795, 4962, 5379, 5436, 5646, 6325], 'Purcell': [680, 3796, 5380, 5437, 5647], 'Bennett': [682, 3798, 5382, 5439, 5649], 'M.': [683, 715, 755, 830, 908, 1075, 1194, 1371, 1379, 1704, 1712, 1799, 1807, 1915, 1919, 1921, 2088, 2094, 2135, 2213, 2229, 2304, 2320, 3184, 3200, 3289, 3376, 3799, 3816, 3851, 3857, 4151, 4387, 4698, 4822, 4876, 4942, 4958, 5023, 5121, 5132, 5138, 5201, 5207, 5383, 5400, 5440, 5457, 5503, 5509, 5581, 5587, 5650, 5667, 5826, 5939, 5978, 6009, 6177, 6183], 'Kansagara': [684, 3800, 5384, 5441, 5651], 'D.': [685, 711, 765, 918, 1381, 1714, 1809, 1956, 2092, 3801, 3817, 3855, 4161, 4391, 5019, 5117, 5136, 5205, 5385, 5401, 5442, 5458, 5507, 5585, 5652, 5668, 6181], 'Syed': [686, 3802, 5386, 5443, 5653], 'A.': [687, 1083, 1188, 1334, 1357, 1469, 1549, 1667, 1690, 1768, 1772, 2133, 2205, 2207, 2211, 2267, 2296, 2298, 2302, 3176, 3178, 3182, 3287, 3803, 4066, 4181, 4696, 4814, 4816, 4820, 4868, 4870, 4874, 4934, 4936, 4940, 5237, 5315, 5387, 5444, 5654, 5824, 5867, 5937, 5976, 6007], 'Marsh': [688, 3804, 5388, 5445, 5655], 'J.L.': [689, 3805, 5389, 5446, 5656], 'Development.': [690, 703, 3806, 5390, 5447, 5657], '120:': [692, 3808, 5392, 5449, 5659], '347-360Crossref': [693, 3809, 5393, 5450, 5660], '9Krasnow': [697], 'R.E.': [698], 'Wong': [699], 'L.L.': [700], 'Adler': [701], '1995;': [704, 1556, 2215, 2243, 2306, 2334, 2352, 2753, 3068, 3186, 3214, 3232, 4073, 4188, 4824, 4878, 4944, 4972, 4990, 5244, 5322, 5884], '121:': [705], '4095-4102Crossref': [706], '10Strutt': [710], 'Weber': [712, 5020, 5118], 'U.': [713, 1355, 1688, 5021, 5119], 'Mlodzik': [714, 2093, 3856, 5022, 5120, 5137, 5206, 5508, 5586, 6182], 'Nature.': [716, 770, 923, 4166, 4396, 5024, 5122], '387:': [718, 5026, 5124], '292-295Crossref': [719, 5027, 5125], '(482)': [722, 5030, 5128], 'In': [725, 789, 945, 3093, 4489, 5064, 5188, 5298, 5551, 5895], 'addition,': [726, 946, 4490, 5189], 'heterologous': [727], 'expression': [728, 2677, 3352, 3363, 3567, 3926, 4126, 5570, 6215, 6395, 6407, 6414], 'Dfz2': [730, 740], '(Drosophila': [731], 'fzhomolog)': [732], 'cells': [734, 1512, 2193, 2464, 2485, 2508, 2516, 3311, 3328, 3343, 3454, 3639, 4059, 4139, 4147, 4222, 4245, 4474, 4895, 4932, 5199, 5365, 6021, 6350], 'normally': [736], 'express': [739], 'respond': [744], 'reconstituted': [747], 'responsiveness': [749], '(11Bhanot': [752, 905, 4148], 'P.': [753, 866, 906, 1035, 1252, 1605, 1630, 1831, 1870, 2235, 2326, 3206, 3412, 4149, 4964], 'Brink': [754, 907, 4150], 'Harryman': [756, 909, 4152], 'C.': [757, 910, 1151, 1346, 1375, 1601, 1679, 1708, 1803, 1866, 3361, 3577, 4153], 'Hsieh': [758, 911, 4154], 'J.C.': [759, 912, 2231, 2322, 3202, 4155, 4960], 'Wang': [760, 913, 999, 4156, 6318], 'Y.': [761, 858, 914, 1000, 1055, 1079, 3404, 4157, 6319], 'Macke': [762, 859, 915, 3405, 4158], 'J.P.': [763, 860, 916, 998, 3406, 4159, 4385, 6317], 'Nathans': [766, 873, 919, 1001, 3419, 4162, 6320, 6384], '1996;': [771, 878, 924, 1066, 1088, 1198, 1256, 1607, 1872, 1935, 3424, 4167, 4397], '382:': [772, 925, 4168, 4398], '225-230Crossref': [773, 926, 4169], '(1228)': [776, 929, 4172], 'mechanism': [782, 1489, 6107], 'appears': [783, 974, 1751, 2111, 3784], 'be': [785, 966, 976, 1651, 2055, 3494, 3605, 4522, 5169, 5622, 5766, 5802, 5901, 6160, 6361], 'mammals.': [788, 6072], 'addition': [790, 2957, 5086], 'existence': [793], 'large': [796], 'number': [797, 1140, 1245, 2063, 4692], 'homologs,': [800], 'there': [801, 947, 973, 2007, 4445, 5280, 5529, 5620, 5763, 5808, 6142], 'homologs': [804, 817, 1023, 1566], 'Fz,': [806], 'Dsh,': [807, 1531, 4046, 6120], 'Arm,': [809], 'Pan.': [811, 5187], 'More': [812], 'than': [813, 3340, 4259, 4853, 5497], 'eight': [814], 'Fz': [816, 898, 937, 958, 983, 6286], 'cloned': [820], 'sequenced': [822], '(12Chan': [823, 3369], 'S.D.': [824, 3370], 'Karpf': [825, 3371], 'D.B.': [826, 3372], 'Fowlkes': [827, 3373], 'Hooks': [829, 3375], 'Bradley': [831, 3377], 'M.S.': [832, 3378], 'Vuong': [833, 3379], 'V.': [834, 1927, 1949, 1980, 3380], 'Bambino': [835, 3381], 'T.': [836, 1293, 2239, 2330, 3210, 3382, 4968], 'Liu': [837, 3383], 'M.Y.': [838, 3384], 'Arnaud': [839, 3385], 'C.D.': [840, 3386], 'Strewler': [841, 3387], 'G.J.': [842, 3388], 'Nissenson': [843, 3389], 'R.A.': [844, 3390], 'Chem.': [847, 877, 2149, 3393, 3423, 4711, 5839, 5952], '267:': [849, 3395], '25202-25207Abstract': [850, 3396], '13Wang': [857, 3403], 'Abella': [861, 3407], 'B.S.': [862, 3408], 'Andreasson': [863, 3409], 'K.': [864, 1459, 3410], 'Worley': [865, 3411], 'Gilbert': [867, 3413], 'D.J.': [868, 1031, 1063, 1085, 1155, 1467, 3414], 'Copeland': [869, 3415], 'N.G.': [870, 3416], 'Jenkins': [871, 3417], 'N.A.': [872, 3418], '271:': [879, 3425], '4468-4476Abstract': [880, 3426], '(314)': [888, 3434], 'Although': [891, 1406, 5798, 5917, 6018, 6141], 'using': [893, 1509, 2517, 2560, 2616, 2650, 2979, 3084, 3121, 4228, 5153], 'immunostaining': [894], 'various': [897, 902], 'bind': [900, 1175, 1885], 'Scholar),': [931, 1441, 1784, 1839, 5000, 5965], 'it': [932, 3254, 3708, 5190], 'clear': [935], 'whether': [936, 2365, 2986, 3613, 3885, 4124, 4727], 'itself': [939], 'sufficient': [941, 3620, 3659, 4090, 5767, 6362], 'transduce': [943], 'signals.': [944], 'little': [949], 'information': [950], 'about': [951], 'specificity': [953, 3131], 'interactions': [955, 981], 'between': [956, 982, 1897, 3720, 5534], 'affinities': [964], 'cannot': [965], 'measured': [967], 'without': [968], 'purified': [969], 'proteins.': [971], 'However,': [972, 1211, 2047, 5008, 5279, 5422, 5524, 5762, 6239, 6335], 'certain': [977], 'selectivity': [978], 'Wnt-5A-induced': [988], 'axial': [989, 6300], 'duplication': [990, 6301], 'Xenopus': [992, 6303], 'requires': [993], 'Fz-5': [994, 6297, 6306, 6338, 6357], '(14He': [995, 6314], 'X.': [996, 6315], 'Saint-Jeannet': [997, 6316], 'Dawid': [1003, 6322], 'I.': [1004, 1597, 1620, 1862, 3818, 5402, 5459, 5669, 6323], 'Science.': [1007, 1384, 1606, 1631, 1717, 1812, 1871, 1966, 1989, 2268, 5868, 6326], '275:': [1009, 1968, 1991, 6328], '1652-1654Crossref': [1010, 6329], '(416)': [1013, 6332], 'Molecular': [1016], 'cloning': [1017], 'also': [1018, 1241, 1280, 1650, 1790, 2263, 2424, 3108, 3438, 3446, 4627, 4731, 5003, 5225, 6281, 6420], 'several': [1020, 1108, 5623], '(Dvl),': [1024], 'from': [1027, 2723, 3091, 3327, 3342, 4220, 4576, 5357, 5366], '(15Sussman': [1030], 'Klingensmith': [1032, 1550, 4067, 4182, 5238, 5316], 'Salinas': [1034], 'Adams': [1036], 'P.S.': [1037], 'Perrimon': [1040, 1060], '73-86Crossref': [1046], '(153)': [1049], '16Klingensmith': [1052], 'Yang': [1054, 1078], 'Axelrod': [1056], 'J.D.': [1057], 'Beier': [1058, 1080], 'D.R.': [1059, 1081], 'Sussman': [1062, 1084, 1466], 'Mech.': [1064], '58:': [1067], '15-26Crossref': [1068], '(97)': [1071], '17Tsang': [1074], 'Lijam': [1076], 'Wynshaw-Boris': [1082, 1468], 'Dyn.': [1087], '207:': [1089], '253-262Crossref': [1090], '(90)': [1093], 'Amino': [1096, 3479], 'acid': [1097, 3480], 'sequence': [1098, 3481, 3697], 'comparison': [1099], 'Dsh/Dvl': [1103, 1218, 1492, 3487], 'molecules': [1104, 3488, 3492, 6156], 'across': [1105], 'species': [1106], 'highly': [1109, 3505], 'regions.': [1111], 'Most': [1112], 'notable': [1113], 'one': [1116, 3504, 4575], 'located': [1117, 1230], 'central': [1120], 'part': [1121, 1652, 5335], 'molecule': [1124, 3465], 'referred': [1125, 1397], 'disc-large': [1129], 'homology': [1130, 1272, 3482], 'region': [1131, 3601, 4043], 'PDZ': [1133, 1170, 1215, 1227, 1536, 3542, 3581, 5265], 'domain,': [1134, 3657, 3702, 3942], 'found': [1137, 1242, 1578, 2392, 2425, 3252, 3903, 4630, 5099, 5899, 6222], 'PSD-95,': [1144], 'ZO-1,': [1145], 'Discs-large': [1147], '(18Ponting': [1148], 'C.P.': [1149, 1250], 'Phillips': [1150], 'Davies': [1152], 'K.E.': [1153, 1461], 'Blake': [1154], '19:': [1158], '469-479Crossref': [1159], '(355)': [1162], 'Studies': [1165], 'PSD-95': [1173], 'C-terminal': [1178, 1223, 3534, 3600, 3615, 3625, 4042], 'motif': [1179], 'four': [1181], 'amino': [1182, 3627], 'acids': [1183, 3628], '(Xaa-Thr/Ser-Xaa-Val)': [1184], '(19Doyle': [1185], 'D.A.': [1186], 'Lee': [1187, 1301], 'Lewis': [1189], 'Kim': [1191], 'E.': [1192, 1599, 1864], 'Sheng': [1193], 'MacKinnon': [1195], '85:': [1199], '1067-1076Abstract': [1200], '(972)': [1208], 'ligands': [1212], 'remain': [1219], 'unknown.': [1220], 'At': [1221], 'side': [1224], '(Dishevelled,': [1233], 'egl-10,': [1234], 'andpleckstrin)': [1235], 'domain.': [1236, 1405], 'Similar': [1237], 'motifs': [1239], 'other': [1247, 2065, 5905], '(20Ponting': [1249], 'Bork': [1251], 'Trends': [1253], 'Sci.': [1255, 1354, 1687], '21:': [1257], '245-246Abstract': [1258], '(144)': [1264], 'shares': [1271], 'newly': [1275], 'protein,': [1277], 'Axin,': [1278], '(21Zeng': [1288], 'L.': [1289, 4389], 'Fagotto': [1290], 'F.': [1291, 1308, 1547, 2209, 2300, 3180, 4064, 4179, 4818, 4872, 4938, 5235, 5313], 'Zhang': [1292], 'Hsu': [1294], 'W.': [1295, 1383, 1716, 1811, 4395], 'Vasicek': [1296], 'T.J.': [1297], 'Perry': [1298], 'III,': [1299], 'W.L.': [1300], 'J.J.': [1302], 'Tilghman': [1303], 'S.M.': [1304], 'Gumbiner': [1305], 'B.M.': [1306], 'Costantini': [1307], '90:': [1311, 1472], '181-192Abstract': [1312], '(795)': [1320], '22Ikeda': [1323], 'S.': [1324, 1326, 1332, 1356, 1544, 1603, 1628, 1657, 1659, 1665, 1689, 1868, 1925, 3819, 4061, 4176, 5232, 5310, 5403, 5460, 5670], 'Kishida': [1325, 1658], 'Yamamoto': [1327, 1660], 'Murai': [1329, 1662], 'Koyama': [1331, 1664], 'Kikuchi': [1333, 1666], 'EMBO': [1335, 1668, 1775], '17:': [1338, 1671], '1371-1384Crossref': [1339, 1672], '(1101)': [1342, 1675], '23Sakanaka': [1345, 1678], 'Weiss': [1347, 1680], 'J.B.': [1348, 1681], 'Williams': [1349, 1682], 'L.T.': [1350, 1683], 'Proc.': [1351, 1684], 'Natl.': [1352, 1685], 'Acad.': [1353, 1686], '95:': [1359, 1692], '3020-3023Crossref': [1360, 1693], '(283)': [1363, 1696], '24Behrens': [1366, 1699], 'Jerchow': [1368, 1701, 1796], 'B.': [1369, 1595, 1616, 1618, 1702, 1797, 1860, 1963, 1986], 'Wurtele': [1370, 1703, 1798], 'Grimm': [1372, 1705, 1800], 'Asbrand': [1374, 1707, 1802], 'Wirtz': [1376, 1709, 1804], 'Kuhl': [1378, 1711, 1806, 4386], 'Wedlich': [1380, 1713, 1808, 4390], 'Birchmeier': [1382, 1715, 1810, 4394], '280:': [1386, 1719, 1814], '596-598Crossref': [1387, 1720, 1815], '(1113)': [1390, 1723, 1818], 'DIX': [1401, 1534, 5263], '(Dishevelled': [1402], 'Axin)': [1404], 'knock-out': [1409], 'Dvl-1': [1411, 2431, 2645, 2684, 3317, 3330, 3355, 3449, 3464, 3476, 3552, 3570, 3603, 3666, 4130, 4204, 4252, 4330, 4482, 4737, 5559, 5564, 5573, 5697, 6076, 6090], 'did': [1412, 4547, 4653, 6341], 'display': [1414], 'any': [1415], 'dramatic': [1418], 'developmental': [1419], 'exhibited': [1421], 'knock-outs': [1427], '(5Cadigan': [1428, 1736, 2018, 2073, 4288, 6127, 6162], 'behavioral': [1442], 'neurological': [1444], 'abnormalities': [1445], 'were': [1446, 2465, 2489, 2499, 2543, 2558, 2572, 2610, 2636, 2663, 2694, 2721, 2782, 2790, 2838, 2886, 2925, 2953, 2965, 2975, 3013, 3138, 3312, 3477, 3514, 3582, 3635, 3676, 3920, 4197, 4218, 4307, 4338, 4361, 4425, 5565, 5921, 6241], 'observed': [1447, 3447], '(25Lijam': [1448], 'Paylor': [1450], 'McDonald': [1452], 'M.P.': [1453], 'Crawley': [1454], 'J.N.': [1455], 'Deng': [1456], 'C.X.': [1457], 'Herrup': [1458], 'Stevens': [1460], 'Maccaferri': [1462], 'G.': [1463], 'McBain': [1464], 'C.J.': [1465], '895-905Abstract': [1473], '(406)': [1481], 'Despite': [1484], 'great': [1485, 6102], 'interest,': [1486], 'molecular': [1488], 'transduction': [1497, 3088, 5073], 'largely': [1501, 5226], 'unknown,': [1502], 'especially': [1503], 'systems.': [1506], 'One': [1507], 'study': [1508, 4038, 5230, 5304], 'cultures': [1510], 'ofDrosophila': [1511], 'showed': [1513, 3331, 6063], 'overexpression': [1515], 'induce': [1519, 6207], 'elevation': [1520], 'portion': [1529, 3616], 'containing': [1532, 1909, 2472, 2796, 2910, 3031, 3895], 'domains,': [1537, 2442], 'such': [1541], '(26Yanagawa': [1543, 4060, 5231, 5309], 'van': [1545, 1916, 1954, 4062, 4177, 5233, 5311], 'Leeuwen': [1546, 4063, 4178, 5234, 5312], 'Wodarz': [1548, 4065, 4180, 5236, 5314], '9:': [1557, 4074, 4189, 5245, 5323], '1087-1097Crossref': [1558, 4075, 4190, 5246, 5324], '(341)': [1561, 4078, 4193, 5249, 5327], 'Zw-3': [1568], 'GSK-3β1': [1572], 'β-catenin,': [1574], 'respectively.': [1575, 4752], 'GSK': [1576, 1726], 'form': [1580, 3145], 'complex': [1582, 1655, 1735], 'product': [1587], '(APC)': [1592], '(27Rubinfeld': [1594, 1859], 'Albert': [1596, 1619, 1861], 'Porfiri': [1598, 1863], 'Fiol': [1600, 1865], 'Munemitsu': [1602, 1627, 1867], 'Polakis': [1604, 1629, 1869], '272:': [1608, 1873], '1023-1026Crossref': [1609, 1874], '(1301)': [1612, 1877], '28Rubinfeld': [1615], 'Souza': [1617], 'Muller': [1621], 'O.': [1622, 1931], 'Chamberlain': [1623], 'S.H.': [1624], 'Masiarz': [1625], 'F.R.': [1626], '1993;': [1632], '262:': [1633], '1731-1734Crossref': [1634], '(1177)': [1637], 'evidence': [1641, 6145, 6246], 'indicates': [1642, 4512, 4602], 'Axin': [1644], 'its': [1646, 2172, 3917, 4112, 4656, 4660, 5044, 5088, 5710, 5749], 'homolog,': [1647], 'Conductin,': [1648], '(22Ikeda': [1656], 'phosphorylate': [1730], 'APC': [1731, 1750, 1821, 1843], 'destabilize': [1733, 1857], 'promoting': [1757], 'degradation': [1759], 'ubiquitination': [1763], 'pathways': [1764, 2012, 2115, 2186, 2373, 5434, 5865, 5974, 6034], '(29Aberle': [1765], 'Bauer': [1767], 'Stappert': [1769], 'Kispert': [1771], 'Kemler': [1773], '16:': [1778], '3797-3804Crossref': [1779], '(2160)': [1782], 'proposed': [1791], 'Conductin': [1793], '(24Behrens': [1794], 'originally': [1823], 'tumor': [1827], 'suppressor': [1828], '(30Polakis': [1830], 'Biochim.': [1832], 'Biophys.': [1833, 2137, 3291, 4700, 5828, 5941, 5980, 6011], 'Acta.': [1834, 2138, 3292, 4701, 5829, 5942, 5981, 6012], '1332:': [1836], '127-147PubMed': [1837], 'mutations': [1841], 'associated': [1846], 'human': [1848, 6387], 'colorectal': [1849], 'cancers': [1850], 'lose': [1853], 'ability': [1855, 3549, 4618, 4657, 4926, 5045, 5089, 5272], 'β-Catenin': [1880, 4370], 'high': [1886, 2652], 'mobility': [1887], 'group': [1888], 'box': [1889], 'factors': [1891], 'TCF-LEF-1': [1894], 'family.': [1895], 'Complexes': [1896], 'Tcf/LEF-1': [1900], 'strong': [1902, 2288, 5374], 'transcriptional': [1903, 2182, 3119], 'reporter': [1906, 2404, 2701, 2731, 2779, 3029, 3042, 3100, 4406, 4433, 4484, 6417], 'constructs': [1908, 2693], 'Tcf-LEF-1': [1911], 'recognition': [1912], 'sequences': [1913, 3682, 4605], '(31Molenaar': [1914], 'de': [1917, 1957], 'Wetering': [1918], 'Oosterwegel': [1920], 'Peterson-Maduro': [1922], 'Godsave': [1924], 'Korinek': [1926, 1979], 'Roose': [1928], 'Destree': [1930], 'Clevers': [1932, 1964, 1983], '86:': [1936], '391-399Abstract': [1937], '(1619)': [1945], '32Korinek': [1948], 'Barker': [1950, 1981], 'Morin': [1952], 'P.J.': [1953, 1976], 'Wichen': [1955], 'Weger': [1958], 'Kinzler': [1960, 1987], 'K.W.': [1961, 1988], 'Vogelstein': [1962, 1985], '1784-1787Crossref': [1969], '(2937)': [1972], '33Morin': [1975], 'Sparks': [1977], 'A.B.': [1978], '1787-1790Crossref': [1992], '(3505)': [1995], 'Caenorhabditis': [2003], 'elegans': [2004], 'suggested': [2005, 2524, 5011, 5330], 'exist': [2009], 'independent': [2013], 'TCF/LEF-1': [2017, 3968, 4377], 'dsh': [2035], 'genes': [2036], 'tissue': [2040], 'polarity': [2041, 3789, 5176, 5376, 5796], 'pathway,': [2042, 2059, 5789, 6154], 'regulates': [2044, 5081, 6111], 'orientation.': [2046], 'wg,arm(β-catenin': [2048], 'homolog),': [2049], 'dtcfdo': [2051], 'genes,fuzzy,': [2066], 'inturned,': [2067], 'rhoA,': [2068], 'andbsk': [2069], '(DJNK)': [2070], '34Boutros': [2087, 5131, 6176], 'Paricio': [2089, 3852, 5133, 5202, 5504, 5582, 6178], 'Strutt': [2091, 3854, 5135, 5204, 5506, 5584, 6180], '94:': [2097, 3860, 5141, 5210, 5512, 5590, 6186], '109-118Abstract': [2098, 3861, 5142, 5211, 5513, 5591, 6187], '(664)': [2106, 3869, 5150, 5219, 5521, 5599, 6195], 'functions.': [2118], 'Mammalian': [2119, 2277, 5853], 'belongs': [2121], 'superfamily': [2124], 'mitogen-activated': [2126, 3159], 'kinases': [2128], '35Minden': [2132], 'Karin': [2134, 2212, 2303, 3183, 3288, 4697, 4821, 4875, 4941, 5825, 5938, 5977, 6008], '1333:': [2140, 3294, 4703, 5831, 5944, 5983, 6014], '85-104PubMed': [2141, 3295, 4704, 5832, 5945, 5984, 6015], 'Scholar': [2143], '36Gutkind': [2145, 4707, 5835, 5948], 'J.S.': [2146, 2241, 2332, 3212, 4708, 4970, 5836, 5949], '273:': [2151, 4713, 5841, 5954], '1839-1842Abstract': [2152, 4714, 5842, 5955], '(691)': [2160, 4722, 5850, 5963], 'phosphorylates': [2164, 3282], 'N': [2166, 3579], 'terminus': [2167], 'proto-oncogene': [2169], 'related': [2173], 'ATF2,': [2176], 'leading': [2177, 2187, 5791], 'activity.': [2183, 2390, 4430], 'best-characterized': [2185], 'those': [2195, 4260], 'mediated': [2196], 'GTP-binding': [2199], 'Rac': [2201, 2254, 5920], '(37Minden': [2204, 2295, 3175, 4813, 4867, 4933], 'Lin': [2206, 2297, 3177, 4815, 4869, 4935], 'Claret': [2208, 2299, 3179, 4817, 4871, 4937], 'Abo': [2210, 2301, 3181, 4819, 4873, 4939], '81:': [2216, 2244, 2307, 2335, 2353, 2754, 3069, 3187, 3215, 3233, 4825, 4879, 4945, 4973, 4991, 5885], '1147-1157Abstract': [2217, 2308, 3188, 4826, 4880, 4946], '(1446)': [2223, 2314, 3194, 4832, 4886, 4952], '38Coso': [2226, 2317, 3197, 4955], 'O.A.': [2227, 2318, 3198, 4956], 'Chiariello': [2228, 2319, 3199, 4957], 'Yu': [2230, 2321, 3201, 4959], 'Teramoto': [2232, 2323, 3203, 4961], 'Crespo': [2234, 2325, 3205, 4963], 'Xu': [2236, 2327, 3207, 4965], 'Miki': [2238, 2329, 3209, 4967], 'Gutkind': [2240, 2331, 3211, 4969, 6398], '1137-1146Abstract': [2245, 2336, 3216, 4974], '(1567)': [2251, 2342, 3222, 4980], 'belong': [2257], 'Rho': [2260, 4677, 4915, 5912], 'family,': [2261, 4916, 5913], 'includes': [2264], 'RhoA': [2265, 5009, 5800, 5815, 5854, 6065, 6094], '(39Hall': [2266, 5866], '279:': [2270, 5870], '509-514Crossref': [2271, 5871], '(5220)': [2274, 5874], 'RhoA,': [2278, 4910, 5041], 'however,': [2279], 'weak': [2282], 'activator': [2283, 2289], 'but': [2286, 2398, 3260, 3790, 5640, 5731, 5778, 6263], '(SRF)': [2294], '40Hill': [2345, 3225, 4983, 5877], 'C.S.': [2346, 2747, 3062, 3226, 4984, 5878], 'Wynne': [2347, 2748, 3063, 3227, 4985, 5879], 'Treisman': [2349, 2750, 3065, 3229, 4987, 5881], '1159-1170Abstract': [2354, 2755, 3070, 3234, 4992, 5886], '(1207)': [2360, 2761, 3076, 3240, 4998, 5892], 'To': [2363, 2984, 3458, 3611, 4725, 4769], 'determine': [2364, 3459, 4726, 6105], 'interact': [2368, 4375, 5014], 'JNK-': [2370, 2991], 'RhoA-linked': [2372, 2993], 'we': [2377, 2423, 3251, 3883, 4105, 4789, 5002, 5034, 5067, 5098, 6240], 'tested': [2378, 3109, 3246, 3558, 3643, 3884, 4123, 4339, 4790, 5035, 6199, 6282], 'effects': [2380, 2996, 4108, 5555], 'ectopically': [2382], 'c-Jun-': [2386], 'SRF-mediated': [2388, 2400], 'c-Jun-mediated': [2397, 3258], 'genes,': [2405], 'suggesting': [2406], 'regulate': [2410, 4379, 4622, 4659, 5091, 6093], 'c-Jun.': [2411, 3106, 3127, 3275], 'confirmed': [2414, 3755, 5004], 'observation': [2417, 3758, 4492], 'activates': [2420, 3148, 3284, 4483, 5078, 5195, 6251], 'JNK.': [2421, 3610, 3663, 5164], 'Moreover,': [2422, 4265, 5097], 'NIH': [2462], '3T3': [2463], 'maintained': [2466], "Dulbecco's": [2468], 'modified': [2469], "Eagle's": [2470], 'medium': [2471, 2537], '10%': [2473, 2811], 'fetal': [2474], 'bovine': [2475], 'at': [2477, 2713, 2854, 2930, 3923, 5567], '37': [2478], '°C': [2479, 2856, 2932], 'under': [2480, 4667], '5%': [2481], 'CO2.': [2482], 'For': [2483, 2726, 5987], 'transfection,': [2484], '(5': [2486], '×': [2487], '104cells/well)': [2488], 'seeded': [2490], 'into': [2491, 3497], '24-well': [2492], 'plates': [2493], 'day': [2495], 'before': [2496], 'transfection.': [2497], 'Cells': [2498, 2787, 4196], 'transfected': [2500, 3313], '0.25': [2502], 'μg': [2503, 2511], 'DNA/well': [2505, 2513], '0.5': [2510, 2852], 'NIH3T3': [2515, 3453], 'LipofectAMINE': [2518], 'Plus': [2519], '(Life': [2520], 'Technologies,': [2521], 'Inc.),': [2522], 'manufacturer.': [2527], 'transfection': [2529, 4324], 'stopped': [2531], 'switching': [2533], 'normal': [2535, 5771], 'after': [2538], '3': [2539, 2890, 3368, 3674, 3732], 'h.': [2540, 4215], 'Cell': [2541, 2570], 'extracts': [2542], 'collected': [2544], '24': [2545, 4214], 'h': [2546, 2853, 2881], 'later': [2547], 'luciferase': [2549, 2565, 2599, 2608, 3028, 3053, 3099, 4423, 4451, 4459, 4499, 4507, 4554], 'assays,': [2550, 2552], 'Western': [2554, 4226], 'analysis.': [2555], 'Luciferase': [2556], 'assays': [2557], 'performed': [2559, 2926], 'Boehringer': [2561], 'Mannheim': [2562], 'Constant': [2563], 'Light': [2564], 'assay': [2566, 4428, 4519, 4578, 5362], 'kit': [2567], 'instructed.': [2569], 'lysates': [2571, 2837], 'first': [2573, 4122], 'taken': [2574], 'determining': [2576], 'intensity': [2578, 2615, 2621], 'emitted': [2579], '(GFP)': [2584], 'Wallac': [2588], 'multi-counter,': [2589], 'capable': [2592], 'counting': [2594], 'luminescence.': [2597], 'Then,': [2598], 'substrate': [2600, 3339], 'added': [2602], 'lysates,': [2606], 'activities': [2609, 3002], 'determined': [2611, 3019, 4308], 'measuring': [2613], 'luminescence': [2614], 'same': [2618, 3123, 5569], 'counter.': [2619], 'Luminescence': [2620], 'normalized': [2623], 'against': [2624], 'intensity.': [2626], 'wild': [2628, 2680, 3912, 3918, 4638, 5498, 5607], 'type': [2629, 2681, 3913, 3919, 4639, 5499, 5608], 'deletion': [2631, 3667, 5254, 5332], 'generated': [2637, 3515, 3677], 'polymerase': [2639, 2656], 'chain': [2640], 'reaction': [2641], 'cDNA': [2646, 3025, 4200, 4207], 'template': [2649], 'fidelity': [2653], 'thermostable': [2654], 'DNA': [2655, 2697], 'Pfu(Stratagene,': [2657], 'CA).': [2658], 'Myc': [2659, 4233], 'epitope': [2660], 'tags': [2661], '(EQKLISEEDL)': [2662], 'introduced': [2664], 'C': [2667, 3590, 4839], 'termini': [2668], 'full-length': [2671], 'mutant': [2673, 2685, 3762, 3893, 4846, 4858, 5039], 'molecules.': [2675], 'Wnt1,': [2679], 'Dvls,': [2682], 'driven': [2687], 'cytomegalovirus': [2690], 'promoter.': [2691], 'All': [2692, 4279], 'verified': [2695], 'sequencing.': [2698], 'construct': [2703, 3030, 4434], 'kindly': [2705], 'provided': [2706, 2783], 'Dr.': [2708], 'Grosschedl': [2709, 4392, 6411], '(University': [2710], 'California': [2712], 'San': [2714], 'Franscisco).': [2715], 'Elk-': [2716], 'c-Jun-reporter': [2718], 'systems': [2720, 3090, 3137, 5363], 'purchased': [2722], 'Strategene,': [2724], 'CA.': [2725], 'construction': [2728], 'plasmid,': [2733, 6396], 'SRE': [2734], 'derivative,': [2735], 'SRE.L,': [2736, 3038], 'synthesized': [2738], 'exactly': [2739], 'described': [2741, 5069], '(Hill': [2743], 'et': [2744, 5307, 5578], 'al.': [2745, 5308, 5579], '(40Hill': [2746, 3061], 'Scholar)).': [2763], 'SER.L': [2764], 'inserted': [2766], 'front': [2768, 4416], 'TK': [2771], 'minimal': [2772, 4419], 'promoter-luciferase': [2773], 'gene.': [2774, 3043], 'Lef-1': [2775], 'Lef': [2778], 'plasmid': [2781, 6415], 'Rudolf': [2785, 6410], 'Grosschedl.': [2786], 'expressing': [2788], 'JNK-HA': [2789, 3562], 'lysed': [2791], 'lysis': [2794, 2894], 'buffer': [2795, 2895, 2909], '1%': [2797], 'Nonidet': [2798], 'P-40,': [2799], '137': [2800], 'mm': [2801, 2805, 2814, 2818, 2821, 2912, 2920], 'sodium': [2802, 2815, 2822], 'chloride,': [2803], '20': [2804, 2841, 2873], 'Tris,': [2806], 'pH': [2807, 2914], '7.4,': [2808, 2915], '1': [2809, 2817, 2861, 2919, 5487, 5501, 6083], 'mmdithiothreitol,': [2810], 'glycerol,': [2812], '10': [2813, 2916, 2937, 2941], 'fluoride,': [2816], 'pyrophosphate,': [2819], '2': [2820, 3360, 3509, 3576, 6229], 'vanadate,': [2823], 'CompleteTM': [2825], 'protease': [2826, 2900], 'inhibitors': [2827, 2903], '(Boehringer': [2828], 'Mannheim,': [2829], 'used': [2830, 4426, 6037], 'instructions': [2833], 'suggest).': [2834], 'precleared': [2839], 'μl': [2842, 2862, 2874], 'A/G-Sepharose': [2845, 2877], 'beads': [2846, 2878], '(Santa': [2847], 'Cruz': [2848], 'Biotech,': [2849], 'CA)': [2850, 2871], '4': [2855, 5548], 'then': [2858], 'incubated': [2859], 'monoclonal': [2864], 'anti-HA': [2865], 'tag': [2866, 3326, 4234], 'antibody': [2867], '(Berkeley': [2868], 'Antibody': [2869], 'Company,': [2870], '3.5': [2880], 'ice.': [2883], 'immunocomplexes': [2885], 'pelleted': [2887], 'washed': [2889], 'times': [2891], 'cold': [2893, 2907], 'absence': [2898, 4563], 'phosphatase': [2902], 'twice': [2905], '25': [2911], 'HEPES,': [2913], 'mmMgCl2,': [2917], 'dithiothreitol.': [2921], 'reactions': [2924, 2952], '30': [2928, 2931], 'min': [2929], 'presence': [2935, 4559], 'μCi': [2938], '[γ-32P]ATP,': [2940], 'μm': [2942], 'ATP,': [2943], 'excess': [2946], 'substrate,': [2949], 'c-Jun-GST.': [2950], 'terminated': [2954], '4×': [2959], 'SDS': [2960], 'sample': [2961], 'buffer.': [2962], 'samples': [2964], 'boiled': [2966], 'loaded': [2968], '12%': [2970], 'SDS-PAGE': [2971], 'gels.': [2972], 'visualized': [2976], 'quantified': [2978], 'PhosphorImager': [2981], '(Molecular': [2982], 'Dynamics).': [2983], 'test': [2985, 3612], 'pathways,': [2994], 'overexpressed': [2998], '(regulated': [3005, 3010, 3116], 'JNK)': [3007], 'SRF': [3009, 3017, 3046, 3060, 3149, 3262, 5861], 'RhoA)': [3012], 'examined.': [3014, 3307], 'Activation': [3015, 3442], 'cotransfection': [3021], 'mutated': [3033], 'c-Fos': [3034], 'element,': [3037], 'upstream': [3039, 5711, 5750], 'Because': [3044, 3716, 3872], 'only': [3045, 3718, 3787, 5635, 5719, 5727], 'binds': [3047], 'SER.L,': [3049], 'SRE.L-mediated': [3050], 'production': [3051], 'mainly': [3054], 'depends': [3055, 3102], 'studied': [3083], 'PathDetect': [3086], 'reporting': [3089, 3136, 3249], 'Stratagene.': [3092], 'system,': [3095], 'effect': [3111, 6284, 6366], 'Elk': [3115], 'Ras)-dependent': [3118], 'method': [3124], 'Positive': [3128], 'controls': [3129], 'Fig.': [3141, 3359, 3575, 3650, 3673, 4354, 5054], '1;': [3142], 'activated': [3144, 3154, 3906], 'c-Jun,': [3151], 'whereas': [3152, 3589, 5576], 'forms': [3155], 'Ras': [3157], 'potent': [3164], 'activators': [3165], 'Elk.': [3167], 'These': [3168, 3268], 'consistent': [3171, 4284, 4572, 5227], 'previous': [3173, 4037, 4286], 'findings': [3174, 4287, 5110, 5223, 5617], 'When': [3243, 3689, 4431], 'systems,': [3250], 'significantly': [3256, 3332, 4269, 4760, 5603], 'Elk-mediated': [3264], '(Fig.': [3266, 3349, 3508, 3587, 3593, 3714, 3731, 3772, 3928, 4248, 4253, 4276, 4325, 4453, 4467, 4509, 4591, 4646, 4765, 6082], '1).': [3267], 'data': [3269, 5526, 5629, 6044], 'It': [3276, 3957, 6098], '(35Minden': [3286, 4695, 5823, 5936, 5975, 6006], 'Monkey': [3308], 'kidney': [3309], 'cDNA-encoding': [3315], 'JNK-HA.': [3319], 'immunoprecipitated': [3322], 'HA': [3325], 'coexpressing': [3329, 3344, 4246, 4261], 'higher': [3333, 4258, 5604], 'phosphorylating': [3336], 'control': [3346, 4263], '(LacZ)': [3348], '2).': [3350, 3594], 'Heterologous': [3362], 'Dvl-2': [3366], 'Scholar)': [3436, 5152, 5251, 5329, 5601], '(Fig.2).': [3441], '(data': [3455, 4566, 5005, 6236, 6277, 6351], 'shown).': [3457, 4568, 5007, 6238, 6279, 6353], 'portions': [3461], 'responsible': [3467], 'JNK,': [3471, 4666], 'truncation': [3472, 3530, 3535], 'generated.': [3478, 3901], 'analysis': [3483, 5156], 'andDrosophila': [3486, 6020], 'roughly': [3495], 'divided': [3496], 'parts,': [3499], 'each': [3500, 3518], 'contains': [3503, 3654], 'A).': [3510, 3547, 4278], 'Therefore,': [3511, 4889], 'deleting': [3517], 'separately.': [3523], 'are:': [3526], 'N,': [3527, 3763, 4334, 4543], 'mutant;': [3531, 3536], 'C,': [3532, 3675, 4333, 4542], 'deleted': [3545], '(Fig.2': [3546], 'coexpression': [3560, 4266, 6336], 'Both': [3578], 'able': [3583, 4362, 4496, 4586, 6268], '2),': [3588], 'regulation': [3608, 3879, 5721, 5859], '320': [3626], 'Dvl-1,': [3631, 4444], 'designated': [3632], 'C1,': [3634, 3652, 4049, 4546], '(Fig.3': [3640], 'C)': [3641, 4511], 'As': [3647, 4351, 4835, 5051], '3,': [3651], 'Two': [3664], 'additional': [3665], 'mutants,': [3668, 4540, 6262], 'depicted': [3671], 'further': [3679, 3754, 6085], 'delineate': [3680], 'regulation.': [3688, 3750], 'mutant,': [3692], 'C2,': [3693], 'encompasses': [3695], 'downstream': [3698, 4606, 4661], 'Cos-7': [3706, 4138], 'unable': [3710, 6242], '3).': [3715, 3773], 'difference': [3719], 'C2': [3721, 3737], 'C1': [3723, 4088, 4337, 5341], 'lack': [3726, 4924, 5810], 'C),': [3733], 'failure': [3735], 'hypothesis': [3752], 'There': [3774], 'nonlethal': [3777], 'dsh1': [3778, 3783, 3933, 4651, 5371, 5424, 5482, 5633], 'allele': [3779, 5372, 5425, 5634], 'Drosophila.': [3781], 'Homozygous': [3782], 'cause': [3786], 'planar': [3788, 3881, 5175, 5375, 5795], 'wg-like': [3792], '(8Theisen': [3794, 5378, 5435, 5645], '41Fahmy': [3813, 5397, 5454, 5664], 'O.G.': [3814, 5398, 5455, 5665], 'Fahmy': [3815, 5399, 5456, 5666], '1959;': [3820, 5404, 5461, 5671], '33:': [3821, 5405, 5462, 5672], '83-94Google': [3822, 5406, 5463, 5673], '42Perrimon': [3824, 5408, 5465, 5675], 'Mahowald': [3826, 5410, 5467, 5677], '1987;': [3830, 5414, 5471, 5681], '119:': [3831, 5415, 5472, 5682], '587-600Crossref': [3832, 5416, 5473, 5683], '(146)': [3835, 5419, 5476, 5686], 'indsh1': [3840], 'substitution': [3845], 'Met-438': [3847], 'Lys': [3849], '(34Boutros': [3850, 5200, 5502, 5580], 'implicated': [3877], 'affects': [3888, 5636], '(DvlKM)': [3894], 'equivalent': [3897, 5561], 'DvlKM': [3905, 3915, 4620, 4632, 5535, 5557], 'effectively': [3909], '(Fig.4).': [3914], 'even': [3921], 'compared': [3922, 5566, 5611], '4).': [3929], 'although': [3931], '(at': [3935], 'residue': [3936, 3944], '438)': [3937], 'lies': [3938], 'inside': [3939], 'Lys-438': [3945], 'does': [3946, 5182, 5426, 6077, 6091], 'significant': [3952, 4550, 4901, 5532], 'well': [3959, 6060], '(2Nusse': [3969], '7Adler': [4025], 'indicated': [4039], 'corresponding': [4047, 5339], 'incapable': [4051], 'culturedDrosophila': [4058], 'finding,': [4082], 'together': [4083], 'our': [4085, 4668, 5301, 5525, 5552, 5616, 6260], 'Nevertheless,': [4104], 'investigated': [4106], 'β-catenin-TCF/LEF-1-linked': [4116], 'ectopic': [4125], 'Wnt-1': [4128, 4202, 4247, 4442, 6225, 6274], 'up-regulate': [4132, 4344, 5348], '26Yanagawa': [4175], 'cotransfected': [4198, 4221, 4436], 'encoding': [4201, 4208, 4439], 'along': [4205], 'Myc-tagged': [4209], 'GFP': [4212, 4306], 'Cytosol': [4216], 'fractions': [4217], 'prepared': [4219], 'analyzed': [4224], 'blotting': [4227], 'antibodies': [4229], 'specific': [4230], 'GFP.': [4236], 'cytosolic': [4240, 4274, 4368], 'recombinant': [4241], '5': [4249, 4254, 4277, 4355, 4454, 4468, 4510, 4592, 4647, 5055], 'A)': [4250, 6084], 'B)': [4255], 'clearly': [4257, 5817], 'LacZ.': [4264], 'GSK-3β': [4268, 4503], 'decreased': [4270], 'coexpressed': [4305, 4739], 'ensure': [4310, 4770], 'changes': [4313], 'variations': [4322], '5,': [4326], 'B).': [4329, 4768], 'their': [4341], 'abilities': [4342], 'B,': [4356], 'none': [4357, 6264], 'affect': [4364, 4655, 5430], 'β-catenin.': [4369, 5297], '(43Behrens': [4381], 'von': [4383], 'Kries': [4384], 'Bruhn': [4388], '638-642Crossref': [4399], '(2595)': [4402], 'construct,': [4407], 'LEF': [4410, 4534], 'placed': [4414], 'promoter': [4420], 'gene,': [4424], 'cDNAs': [4438], 'marked': [4448], 'increase': [4449, 4457], 'C).': [4455, 4469], 'Wnt-1-': [4462], 'Dvl-1-': [4464], 'LEF-1-dependent': [4466, 4644, 5545], 'contain': [4477], 'endogenous': [4478], 'LEF-1.': [4488], 'Dvl-stimulated': [4506], 'system': [4520], 'regulated': [4523, 5902], 'GSK.': [4527], 'Mutants': [4529], 'Were': [4530], 'Tested': [4531], 'Reporter': [4535], 'Gene': [4536], 'Assay': [4537], 'system.': [4538], 'show': [4549], 'regardless': [4556], '(Fig.5': [4560], 'D)': [4561], 'levels.': [4582, 5278], 'Only': [4583], 'Dvl-N': [4584, 4597], 'LEF1-dependent': [4589, 4600, 4615], 'D).': [4593], 'fact': [4595, 6074], 'β-catenin-LEF-1': [4624], 'investigated.': [4628], 'effective': [4635, 4780], 'E).': [4648], 'effectors,': [4662], 'experimental': [4669], 'conditions.': [4670], 'Rac,': [4673], 'members': [4674], 'stimuli': [4694], 'mediates': [4732], 'Cdc42N17': [4749], 'Rac1N17,': [4751, 6402], 'Neither': [4753], '6,A': [4766], 'dominant-negative': [4773], 'Rac-mediated': [4786], 'inhibition': [4797], 'EGF-induced': [4799, 4848, 4862], 'EGF': [4802], 'previously': [4804], 'and/or': [4811], 'Fig.6,': [4838], 'D,': [4841], 'suppressed': [4847], 'more': [4852], '50%,': [4854], 'almost': [4859], 'completely': [4860], 'abolished': [4861], 'reported': [4866], 'unlikely': [4897], 'another': [4911], 'member': [4912], 'laboratories': [4922], 'genetically': [5013], 'Drosophila(10Strutt': [5018], 'RhoAN19,': [5042], 'Dvl-1-mediated': [5048], 'A,': [5056], 'RhoAN19': [5057], 'failed': [5058], 'Dvl-1-induced': [5061], 'report,': [5066], 'Dvl.': [5076, 6254], 'Our': [5109, 5222, 6043, 6057], 'agree': [5111], 'recent': [5114, 6291], 'reports': [5115], '(10Strutt': [5116], 'epistasis': [5155], 'showing': [5159, 5252, 5630], 'interacts': [5162], 'withDrosophila': [5163], 'correct': [5172], 'establishment': [5173], 'tissues,': [5180], 'require': [5184], 'resulted': [5266], 'loss': [5269], 'apparent': [5283], 'discrepancy': [5284, 5354], 'regard': [5286, 6025], 'contrast': [5299], 'findings,': [5302], 'Yanagawa': [5306], 'still': [5347, 5765], 'Arm.': [5352], 'use': [5359, 6375], 'species.': [5368], 'shows': [5373], 'identified,': [5484], 'less': [5492], 'potency': [5493], 'indicate': [5527, 6045], 'no': [5531, 6144], 'differences': [5533], '(Figs': [5547], '5).': [5550], 'experiments,': [5553], '(the': [5558], 'todsh1)': [5562], 'DvlKM,': [5575], 'Boutros': [5577], 'had': [5602], '1.': [5614], 'If': [5615], 'correct,': [5619], 'possible': [5624], 'explanations': [5625], '1)': [5689], 'Thedsh1': [5690], 'Dsh;': [5699], '2)': [5700], 'disrupt': [5704], 'coupling': [5706, 5745], 'regulators': [5712, 5751], '(such': [5713], 'receptors)': [5715], 'pathway.': [5725], 'affected;': [5737], '3)': [5738], 'partially': [5742], 'reduce': [5743], 'both': [5756, 6224], 'maintain': [5770, 5782], 'functions': [5772, 5784], 'enough': [5780], 'solely': [5792], 'phenotype.': [5797], '(although': [5807], 'biochemical': [5812], 'data),': [5813], 'yet-to-be': [5863], 'mammals,': [5896], 'belonging': [5909], 'Rac.': [5916], 'protein-coupled': [5934], 'they': [5966, 5989], 'instance,': [5988], 'ultraviolet,': [5994], 'toxin': [5995], 'anisomycin,': [5996], 'tyrosine': [5997], 'c-Abl': [5999], 'Pyk2,': [6001], 'TNF-induced': [6003], 'apparently': [6036], 'Dvl/Dsh.': [6042], 'others': [6062], 'irrelevant': [6067], 'SRF-dependent': [6080], 'supports': [6086], 'idea': [6088], 'certainly': [6100], 'interest': [6103], 'signals': [6117], 'Dfz2,': [6119], '(β-catenin),': [6122], 'Pan': [6124], '(TCF)': [6125], 'Fz-Dsh-JNK': [6153], 'Wnt-like': [6155], 'speculated': [6158], 'if': [6200], 'Wnts,': [6202], 'Wnt-1,': [6203], 'Wnt5a,': [6205], 'paracrine': [6212], 'paradigm': [6213], 'Wnt-5a': [6227, 6276, 6313, 6340, 6347, 6368, 6373], 'gave': [6228], '3-fold': [6231], 'obtain': [6244], 'direct': [6245], 'demonstrate': [6248], 'tried': [6257], 'them': [6266], 'block': [6270], 'report': [6292], 'demonstrating': [6293], 'requirement': [6295], 'Wnt-5a-induced': [6299], 'implies': [6304], 'serve': [6308], 'receptor': [6311], 'potentiate': [6343], 'alone': [6358], 'mediating': [6364], 'Alternatively,': [6372], 'thank': [6382, 6421], 'Jeremy': [6383], 'Fz5': [6388], 'cDNA,': [6389], 'Alan': [6390], 'Hall': [6391], 'C3': [6393], 'transferase': [6394], 'Silvio': [6397], 'Cdc42V12,': [6400], 'Cdc42N17,': [6401], 'RhoN19,': [6403], 'JNK-HA,': [6404], 'AFT2-GST': [6406], 'plasmids,': [6408], 'construct.': [6418], 'Huiping': [6422], 'Jiang': [6423], 'Mark': [6425], 'Betz': [6426], 'reading': [6428], 'manuscript.': [6430]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022798578', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-24T15:23:51.624259', 'created_date': '2016-06-24'}